Howard J Federoff

Howard J Federoff

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Howard J Federoff

Howard J Federoff

Publications by authors named "Howard J Federoff"

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Fetal Bovine Serum-Derived Extracellular Vesicles Persist within Vesicle-Depleted Culture Media.

Int J Mol Sci 2018 Nov 9;19(11). Epub 2018 Nov 9.

Translational Laboratory and Biorepository, Department of Neurology, University of California Irvine School of Medicine, Irvine, CA 92697-3910, USA.

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http://dx.doi.org/10.3390/ijms19113538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275013PMC
November 2018

Toward Reproducible Results from Targeted Metabolomic Studies: Perspectives for Data Pre-processing and a Basis for Analytic Pipeline Development.

Curr Top Med Chem 2018 ;18(11):883-895

Translational Laboratory and Biorepository, University of California, Irvine School of Medicine, Irvine, CA 92697, United States.

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http://www.eurekaselect.com/163692/article
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http://dx.doi.org/10.2174/1568026618666180711144323DOI Listing
September 2018

Potential Metabolomic Linkage in Blood between Parkinson's Disease and Traumatic Brain Injury.

Metabolites 2018 Sep 7;8(3). Epub 2018 Sep 7.

Translational Laboratory and Biorepository, Department of Neurology, University of California Irvine School of Medicine, Irvine, CA 92697-3910, USA.

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http://dx.doi.org/10.3390/metabo8030050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161135PMC
September 2018

Plasma microRNA markers of upper limb recovery following human stroke.

Sci Rep 2018 08 22;8(1):12558. Epub 2018 Aug 22.

Georgetown University, Department of Neurology, Washington, DC, USA.

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http://dx.doi.org/10.1038/s41598-018-31020-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105620PMC
August 2018

Plasma metabolomic biomarkers accurately classify acute mild traumatic brain injury from controls.

PLoS One 2018 20;13(4):e0195318. Epub 2018 Apr 20.

Translational Laboratory and Biorepository, Department of Neurology, University of California Irvine, Irvine, CA United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0195318PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909890PMC
July 2018

Precision pharmacology for Alzheimer's disease.

Pharmacol Res 2018 04 16;130:331-365. Epub 2018 Feb 16.

AXA Research Fund & Sorbonne University Chair, Paris, France; Sorbonne University, GRC No. 21, Alzheimer Precision Medicine (APM), AP-HP, Pitié-Salpêtrière Hospital, Boulevard de l'hôpital, F-75013, Paris, France; Brain & Spine Institute (ICM), INSERM U 1127, CNRS UMR 7225, Boulevard de l'hôpital, F-75013, Paris, France; Institute of Memory and Alzheimer's Disease (IM2A), Department of Neurology, Pitié-Salpêtrière Hospital, AP-HP, Boulevard de l'hôpital, F-75013, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2018.02.014DOI Listing
April 2018

Systems healthcare: a holistic paradigm for tomorrow.

BMC Syst Biol 2017 Dec 19;11(1):142. Epub 2017 Dec 19.

Department of Neurology, School of Medicine, Irvine, USA.

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http://dx.doi.org/10.1186/s12918-017-0521-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738174PMC
December 2017

Alpha-Synuclein mRNA Is Not Increased in Sporadic PD and Alpha-Synuclein Accumulation Does Not Block GDNF Signaling in Parkinson's Disease and Disease Models.

Mol Ther 2017 10 15;25(10):2231-2235. Epub 2017 May 15.

Department of Neurology, University of California at Irvine, Irvine, CA 92697, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2017.04.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628770PMC
October 2017

Metabolomic biomarkers of pancreatic cancer: a meta-analysis study.

Oncotarget 2017 Sep 18;8(40):68899-68915. Epub 2017 Aug 18.

Department of Oncology, Georgetown University Medical Center, Washington, DC, United States of America.

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http://dx.doi.org/10.18632/oncotarget.20324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620306PMC
September 2017

Personality and Performance in Specific Neurocognitive Domains Among Older Persons.

Am J Geriatr Psychiatry 2017 Aug 3;25(8):900-908. Epub 2017 Apr 3.

Department of Neurology, University of California, Irvine School of Medicine, Irvine, CA.

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http://dx.doi.org/10.1016/j.jagp.2017.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647872PMC
August 2017

Targeting Microglial Activation States as a Therapeutic Avenue in Parkinson's Disease.

Front Aging Neurosci 2017 8;9:176. Epub 2017 Jun 8.

Department of Neurology, University of California, Irvine, Irvine, CAUnited States.

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http://dx.doi.org/10.3389/fnagi.2017.00176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5463358PMC
June 2017

Biomarker validation: Methods and matrix matter.

Alzheimers Dement 2017 05 21;13(5):608-609. Epub 2016 Dec 21.

Department of Neurology, University of California, Irvine, Irvine, CA, USA.

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http://dx.doi.org/10.1016/j.jalz.2016.11.004DOI Listing
May 2017

PGC-1α Promoter Methylation in Parkinson's Disease.

PLoS One 2015 28;10(8):e0134087. Epub 2015 Aug 28.

Department of Neuroscience, Georgetown University Medical Center, Washington DC, United States of America; Department of Neurology, Georgetown University Medical Center, Washington DC, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0134087PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552803PMC
May 2016

Critical periods after stroke study: translating animal stroke recovery experiments into a clinical trial.

Front Hum Neurosci 2015 29;9:231. Epub 2015 Apr 29.

Department of Rehabilitation Medicine, Center for Brain Plasticity and Recovery, Georgetown University and MedStar National Rehabilitation Hospital Washington, DC, USA ; Department of Neurology, Georgetown University Washington, DC, USA.

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http://dx.doi.org/10.3389/fnhum.2015.00231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413691PMC
May 2015

Immune responses in Parkinson's disease: interplay between central and peripheral immune systems.

Biomed Res Int 2014 13;2014:275178. Epub 2014 Apr 13.

Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20057, USA ; Department of Neurology, Georgetown University Medical Center, Washington, DC 20057, USA.

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http://dx.doi.org/10.1155/2014/275178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005076PMC
January 2015

Using viral-mediated gene delivery to model Parkinson's disease: do nonhuman primate investigations expand our understanding?

Exp Neurol 2014 Jun 22;256:117-25. Epub 2013 Mar 22.

Department of Neurology, Georgetown University, Washington, D.C. 20007, USA; Department of Neuroscience, Georgetown University, Washington, D.C. 20007, USA. Electronic address:

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http://dx.doi.org/10.1016/j.expneurol.2013.03.014DOI Listing
June 2014

The critical need for defining preclinical biomarkers in Alzheimer's disease.

Alzheimers Dement 2014 Jun;10(3 Suppl):S196-212

Department of Neurology, Georgetown University Medical Center, Washington, DC, USA; Department of Neuroscience, Georgetown University Medical Center, Washington, DC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2014.04.015DOI Listing
June 2014

Single-chain fragment variable passive immunotherapies for neurodegenerative diseases.

Int J Mol Sci 2013 Sep 17;14(9):19109-27. Epub 2013 Sep 17.

Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20057, USA.

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http://dx.doi.org/10.3390/ijms140919109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794823PMC
September 2013

Network modeling to identify new mechanisms and therapeutic targets for Parkinson's disease.

Expert Rev Neurother 2013 Jun;13(6):685-93

Georgetown University Medical Center, Washington, DC, USA.

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http://dx.doi.org/10.1586/ern.13.59DOI Listing
June 2013

Microglial activation and antioxidant responses induced by the Parkinson's disease protein α-synuclein.

J Neuroimmune Pharmacol 2013 Mar 10;8(1):94-117. Epub 2012 Oct 10.

Department of Neuroscience, Georgetown University Medical Center, NRB EP08, 3970 Reservoir Road NW, Washington, DC 20057, USA.

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http://dx.doi.org/10.1007/s11481-012-9401-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582877PMC
March 2013

Genomics and bioinformatics of Parkinson's disease.

Cold Spring Harb Perspect Med 2012 Jul;2(7):a009449

Department of Neuroscience, Georgetown University, Washington, DC, USA.

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http://dx.doi.org/10.1101/cshperspect.a009449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3385936PMC
July 2012

Gene therapy for the treatment of Parkinson's disease: the nature of the biologics expands the future indications.

Pharmaceuticals (Basel) 2012 Jun 4;5(6):553-90. Epub 2012 Jun 4.

Translational NeuroTherapy Center, Department of Neurological Surgery, University of California San Francisco, 1855 Folsom Street, Mission Center Building, San Francisco, CA 94103, USA.

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http://dx.doi.org/10.3390/ph5060553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763661PMC
June 2012

EDITORIAL: TECHNOLOGY, INNOVATION, AND HEALTH.

Technol Innov 2012 Apr;13(4):261-262

Medical Center, Georgetown University, Washington, DC, USA.

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http://openurl.ingenta.com/content/xref?genre=article&is
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http://dx.doi.org/10.3727/194982412X13292321140697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987958PMC
April 2012

Technology and innovation: 2010 a year in review.

Cell Transplant 2011 ;20(8):1315-9

Office of Research & Innovation, University of South Florida, Tampa, FL 33612-9444, USA.

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http://journals.sagepub.com/doi/full/10.3727/096368911X59312
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http://dx.doi.org/10.3727/096368911X593127DOI Listing
March 2012

Ectodomain shedding of nectin-1 regulates the maintenance of dendritic spine density.

J Neurochem 2012 Mar 16;120(5):741-51. Epub 2011 Dec 16.

Neuroscience Department, Georgetown University Medical Center, Washington, District of Columbia 20057, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2011.07592.xDOI Listing
March 2012

TECHNOLOGY AND INVENTION.

Technol Innov 2012 ;14(1):1-2

Medical Center, Georgetown University, Washington, DC, USA.

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http://dx.doi.org/10.3727/194982412X13378627621554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171041PMC
January 2012

Characterization of nectin processing mediated by presenilin-dependent γ-secretase.

J Neurochem 2011 Dec 20;119(5):945-56. Epub 2011 Oct 20.

Department of Neuroscience, Georgetown University Medical Center, NW, Washington, District of Columbia, USA.

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http://doi.wiley.com/10.1111/j.1471-4159.2011.07479.x
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http://dx.doi.org/10.1111/j.1471-4159.2011.07479.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217175PMC
December 2011

Disclosure of clinical trial results when product development is abandoned.

Sci Transl Med 2011 Sep;3(102):102cm29

Department of Neurology, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA.

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http://dx.doi.org/10.1126/scitranslmed.3002939DOI Listing
September 2011

Membrane palmitoylated proteins regulate trafficking and processing of nectins.

Eur J Cell Biol 2011 May 2;90(5):365-75. Epub 2011 Mar 2.

Department of Neuroscience, Georgetown University Medical Center, 3970 Reservoir Rd. NW, Washington, DC 20057, USA.

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http://dx.doi.org/10.1016/j.ejcb.2011.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060411PMC
May 2011

Therapeutic potential of vaccines for Alzheimer's disease.

Immunotherapy 2011 Feb;3(2):287-98

Georgetown University Medical Center, 4000 Reservoir Road, NW 120 Building D, Washington, DC 20007, USA.

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http://dx.doi.org/10.2217/imt.10.94DOI Listing
February 2011

Trk retrograde signaling requires persistent, Pincher-directed endosomes.

Proc Natl Acad Sci U S A 2011 Jan 27;108(2):852-7. Epub 2010 Dec 27.

Department of Neurobiology and Behavior, Center for Nervous System Disorders and Program in Neuroscience, Stony Brook University, Stony Brook, NY 11794-5230, USA.

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http://dx.doi.org/10.1073/pnas.1015981108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021064PMC
January 2011

Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease.

Nat Med 2010 Sep 22;16(9):998-1000. Epub 2010 Aug 22.

Neuroregeneration Program, Institute for Cell Engineering, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1038/nm.2199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935926PMC
September 2010

A new research and development policy framework for the biomedical research enterprise.

JAMA 2010 Sep;304(9):1003-4

School of Medicine, Georgetown University Medical Center, Washington, DC, USA.

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http://dx.doi.org/10.1001/jama.2010.1270DOI Listing
September 2010

Future directions for immune modulation in neurodegenerative disorders: focus on Parkinson's disease.

J Neural Transm (Vienna) 2010 Aug 12;117(8):1019-25. Epub 2010 Jun 12.

Department of Neuroscience, Georgetown University Medical Center, Washington, DC, USA.

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http://dx.doi.org/10.1007/s00702-010-0431-6DOI Listing
August 2010

Abeta-directed single-chain antibody delivery via a serotype-1 AAV vector improves learning behavior and pathology in Alzheimer's disease mice.

Mol Ther 2010 Aug 15;18(8):1471-81. Epub 2010 Jun 15.

Interdepartmental Graduate Program in Neuroscience, University of Rochester Medical Center, Rochester, NY, USA.

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http://dx.doi.org/10.1038/mt.2010.111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927061PMC
August 2010

The endoplasmic reticulum stress response factor CHOP-10 protects against hypoxia-induced neuronal death.

J Biol Chem 2010 Jul 6;285(28):21329-40. Epub 2010 May 6.

Department of Neurology, University of Rochester Medical Center, Rochester, New York 14642, USA.

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http://dx.doi.org/10.1074/jbc.M109.095299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898390PMC
July 2010

An improved method for generating consistent soluble amyloid-beta oligomer preparations for in vitro neurotoxicity studies.

J Neurosci Methods 2010 Jul 7;190(2):171-9. Epub 2010 May 7.

Interdepartmental Graduate Program in Neuroscience, Rochester, NY 14642, USA.

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http://dx.doi.org/10.1016/j.jneumeth.2010.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902796PMC
July 2010

Alpha-synuclein mediates alterations in membrane conductance: a potential role for alpha-synuclein oligomers in cell vulnerability.

Eur J Neurosci 2010 Jul 14;32(1):10-7. Epub 2010 Jun 14.

Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20057, USA.

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http://dx.doi.org/10.1111/j.1460-9568.2010.07266.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900531PMC
July 2010

Generating differentially targeted amyloid-beta specific intrabodies as a passive vaccination strategy for Alzheimer's disease.

Mol Ther 2009 Dec 28;17(12):2031-40. Epub 2009 Jul 28.

Center for Neural Development and Disease, University of Rochester Medical Center, Rochester, New York 14642, USA.

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http://dx.doi.org/10.1038/mt.2009.174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788047PMC
December 2009

Drug discovery dilemma and Cura quartet collaboration.

Drug Discov Today 2009 Nov 6;14(21-22):1006-10. Epub 2009 Oct 6.

Office of Planning and Enterprise Development, Georgetown University Medical Center, 4000 Reservoir Road, NW, Washington DC 20057, USA.

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http://dx.doi.org/10.1016/j.drudis.2009.09.007DOI Listing
November 2009

Nur(R1)turing a notion on the etiopathogenesis of Parkinson's disease.

Neurotox Res 2009 Oct 24;16(3):261-70. Epub 2009 Apr 24.

Department of Neurology, Georgetown University Medical Center, 4000 Reservoir Road NW, 120 Building D, Washington, DC 20057, USA.

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http://dx.doi.org/10.1007/s12640-009-9056-7DOI Listing
October 2009

Mutant alpha-synuclein overexpression mediates early proinflammatory activity.

Neurotox Res 2009 Oct 28;16(3):238-54. Epub 2009 Apr 28.

Center for Aging and Developmental Biology, Aab Institute for Biomedical Research, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.

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http://dx.doi.org/10.1007/s12640-009-9053-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877375PMC
October 2009

Death in a gene-therapy trial.

N Engl J Med 2009 Oct;361(18):1811

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http://dx.doi.org/10.1056/NEJMc091613DOI Listing
October 2009

Immune-directed gene therapeutic development for Alzheimer's, prion, and Parkinson's diseases.

J Neuroimmune Pharmacol 2009 Sep 18;4(3):298-308. Epub 2008 Oct 18.

Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20057, USA.

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http://dx.doi.org/10.1007/s11481-008-9133-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2879638PMC
September 2009

Evolving from reductionism to holism: is there a future for systems medicine?

JAMA 2009 Sep;302(9):994-6

Georgetown University Medical Center, Bldg D, 4000 Reservoir Rd NW, Washington, DC 20057, USA.

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http://dx.doi.org/10.1001/jama.2009.1264DOI Listing
September 2009

Development of vaccination approaches for the treatment of neurological diseases.

J Comp Neurol 2009 Jul;515(1):4-14

Department of Neurology, Georgetown University, Washington DC 20057, USA.

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http://dx.doi.org/10.1002/cne.22034DOI Listing
July 2009

HUMMR, a hypoxia- and HIF-1alpha-inducible protein, alters mitochondrial distribution and transport.

J Cell Biol 2009 Jun;185(6):1065-81

Department of Neurology, Center for Neural Development and Disease, University of Rochester School of Medicine & Dentistry, Rochester, NY 14642, USA.

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http://dx.doi.org/10.1083/jcb.200811033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2711615PMC
June 2009

Effects of herpes simplex virus amplicon transduction on murine dendritic cells.

Hum Gene Ther 2009 May;20(5):442-52

Division of Allergy, Immunology, and Rheumatology, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.

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http://dx.doi.org/10.1089/hum.2008.160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828628PMC
May 2009

Immune responses to herpesviral vectors.

Hum Gene Ther 2009 May;20(5):434-41

Center for Aging and Developmental Biology, University of Rochester Medical Center, Rochester, NY 14642, USA.

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http://dx.doi.org/10.1089/hum.2009.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828622PMC
May 2009

Functional effects of AAV2-GDNF on the dopaminergic nigrostriatal pathway in parkinsonian rhesus monkeys.

Hum Gene Ther 2009 May;20(5):511-8

Department of Molecular Imaging and Neuroscience, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.

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http://dx.doi.org/10.1089/hum.2008.201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725183PMC
May 2009

HSV ICP0 recruits USP7 to modulate TLR-mediated innate response.

Blood 2009 Apr 24;113(14):3264-75. Epub 2008 Oct 24.

Institut de Pharmacologie et de Biologie Structurale, Centre National de Recherche Scientifique (CNRS), Unité Mixte de Recherche 5089, Toulouse, France.

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http://dx.doi.org/10.1182/blood-2008-07-168203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401030PMC
April 2009

Chronic neuron-specific tumor necrosis factor-alpha expression enhances the local inflammatory environment ultimately leading to neuronal death in 3xTg-AD mice.

Am J Pathol 2008 Dec 30;173(6):1768-82. Epub 2008 Oct 30.

Department of Microbiology and Immunology, Center for Neural Development and Disease, University of Rochester Medical Center, Rochester, NY 14642, USA.

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http://dx.doi.org/10.2353/ajpath.2008.080528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2626388PMC
December 2008

Proteomic analysis of peripheral leukocytes in Alzheimer's disease patients treated with divalproex sodium.

Neurobiol Aging 2008 Nov 22;29(11):1631-43. Epub 2007 May 22.

Center for Aging and Developmental Biology, Aab Institute for Biomedical Research, University of Rochester School of Medicine and Dentistry, Box 645, 601 Elmwood Avenue, Rochester, NY 14642, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2007.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2621111PMC
November 2008

Synuclein activates microglia in a model of Parkinson's disease.

Neurobiol Aging 2008 Nov 29;29(11):1690-701. Epub 2007 May 29.

Center for Aging and Developmental Biology, Aab Institute for Biomedical Research, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2007.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2621109PMC
November 2008

Identification of a novel nurr1-interacting protein.

J Neurosci 2008 Sep;28(37):9277-86

Department of Environmental Medicine, Center for Aging and Developmental Biology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14624, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.3021-08.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6670918PMC
September 2008

Human interleukin-10 gene transfer is protective in a rat model of Parkinson's disease.

Mol Ther 2008 Aug 10;16(8):1392-9. Epub 2008 Jun 10.

Department of Neurosurgery, University of California San Francisco, San Francisco, California, USA.

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http://dx.doi.org/10.1038/mt.2008.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725180PMC
August 2008

Loss of c/EBP-beta activity promotes the adaptive to apoptotic switch in hypoxic cortical neurons.

Mol Cell Neurosci 2008 Jun 13;38(2):125-37. Epub 2008 Feb 13.

Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.

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http://dx.doi.org/10.1016/j.mcn.2008.01.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2652244PMC
June 2008

Augmentation of anti-tumor responses of adoptively transferred CD8+T cells in the lymphopenic setting by HSV amplicon transduction.

Cancer Immunol Immunother 2008 May 19;57(5):663-75. Epub 2007 Oct 19.

Department of Medicine, Miller School of Medicine at the University of Miami, Sylvester Comprehensive Cancer Center, Miami, FL 33136, USA.

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http://dx.doi.org/10.1007/s00262-007-0405-1DOI Listing
May 2008

Reduced pathology and improved behavioral performance in Alzheimer's disease mice vaccinated with HSV amplicons expressing amyloid-beta and interleukin-4.

Mol Ther 2008 May 11;16(5):845-53. Epub 2008 Mar 11.

Center for Aging and Developmental Biology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA.

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http://dx.doi.org/10.1038/mt.2008.39DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2441486PMC
May 2008

Reduced Pathology and Improved Behavioral Performance in Alzheimer's Disease Mice Vaccinated With HSV Amplicons Expressing Amyloid-β and Interleukin-4.

Mol Ther 2008 May 8;16(5):845-853. Epub 2016 Dec 8.

Center for Aging and Developmental Biology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA; Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA; Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA. Electronic address:

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http://dx.doi.org/10.1038/mt.2008.39DOI Listing
May 2008

CNS delivery of vectored prion-specific single-chain antibodies delays disease onset.

Mol Ther 2008 Mar 8;16(3):481-6. Epub 2008 Jan 8.

Center for Aging and Developmental Biology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.

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http://dx.doi.org/10.1038/sj.mt.6300387DOI Listing
March 2008

Temporal and spatial localization of nectin-1 and l-afadin during synaptogenesis in hippocampal neurons.

J Comp Neurol 2008 Mar;507(2):1228-44

Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.

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http://dx.doi.org/10.1002/cne.21608DOI Listing
March 2008

Hexamethylene bisacetamide leads to reduced helper virus-free HSV-1 amplicon expression titers via suppression of ICP0.

J Gene Med 2008 Feb;10(2):152-64

Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.

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http://dx.doi.org/10.1002/jgm.1130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2440655PMC
February 2008

The good, the bad, and the cell type-specific roles of hypoxia inducible factor-1 alpha in neurons and astrocytes.

J Neurosci 2008 Feb;28(8):1988-93

Department of Neurology, Center for Neural Development and Disease, and Interdepartmental Graduate Program in Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.5323-07.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6671445PMC
February 2008

Gazing into the future: Parkinson's disease gene therapeutics to modify natural history.

Exp Neurol 2008 Jan 11;209(1):101-13. Epub 2007 Oct 11.

Department of Neuroscience, Georgetown University, Washington, DC 20007, USA.

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http://dx.doi.org/10.1016/j.expneurol.2007.09.030DOI Listing
January 2008

Infectivity of herpes simplex virus type-1 (HSV-1) amplicon vectors in dendritic cells is determined by the helper virus strain used for packaging.

J Virol Methods 2007 Oct 2;145(1):37-46. Epub 2007 Jul 2.

Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 672, Rochester, NY 14642, USA.

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http://dx.doi.org/10.1016/j.jviromet.2007.05.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2080840PMC
October 2007

Neuronal specificity of HSV/sleeping beauty amplicon transduction in utero is driven primarily by tropism and cell type composition.

Mol Ther 2007 Oct 24;15(10):1848-55. Epub 2007 Jul 24.

Center for Aging and Developmental Biology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA.

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http://dx.doi.org/10.1038/sj.mt.6300267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2587304PMC
October 2007

HSV-1 amplicon vectors elicit polyfunctional T cell responses to HIV-1 Env, and strongly boost responses to an adenovirus prime.

Vaccine 2007 Oct 30;25(42):7410-21. Epub 2007 Aug 30.

Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.

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http://dx.doi.org/10.1016/j.vaccine.2007.08.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2092414PMC
October 2007

Adoptively transferred tumor-specific T cells stimulated ex vivo using herpes simplex virus amplicons encoding 4-1BBL persist in the host and show antitumor activity in vivo.

Cancer Res 2007 Oct;67(20):10027-37

Department of Microbiology and Immunology, University of Miami Miller School of Medicine, and University of Miami Sylvester Comprehensive Cancer Center, Miami, Florida 33136, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-2391DOI Listing
October 2007

Proteolytic processing of proNGF is necessary for mature NGF regulated secretion from neurons.

Biochem Biophys Res Commun 2007 Sep 20;361(3):599-604. Epub 2007 Jul 20.

Interdepartmental Graduate Program in Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.

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http://dx.doi.org/10.1016/j.bbrc.2007.07.039DOI Listing
September 2007

In cultured astrocytes, p53 and MDM2 do not alter hypoxia-inducible factor-1alpha function regardless of the presence of DNA damage.

J Biol Chem 2007 Jun 9;282(22):16187-201. Epub 2007 Apr 9.

Department of Neurology, Center for Aging and Developmental Biology, University of Rochester School of Medicine and Dentistry, NY 14642, USA.

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http://dx.doi.org/10.1074/jbc.M702203200DOI Listing
June 2007

Translational considerations for CNS gene therapy.

Expert Opin Biol Ther 2007 Mar;7(3):305-18

University of Rochester School of Medicine & Dentistry, Interdepartmental Graduate Program in Neuroscience, Rochester, New York, USA.

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http://dx.doi.org/10.1517/14712598.7.3.305 DOI Listing
March 2007

Reversal of misfolding: prion disease behavioral and physiological impairments recover following postnatal neuronal deletion of the PrP gene.

Neuron 2007 Feb;53(3):315-7

Department of Neurology, Center for Aging and Developmental Biology, Aab Institute for Biomedical Research, University of Rochester School of Medicine and Dentistry, Box 645, 601 Elmwood Avenue, Rochester, NY 14642, USA.

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http://dx.doi.org/10.1016/j.neuron.2007.01.013DOI Listing
February 2007