Howard Chen

Howard Chen

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Howard Chen

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Challenges to Routine Genetic Testing for Inherited Retinal Dystrophies.

Ophthalmology 2019 Oct 24;126(10):1466-1468. Epub 2019 Apr 24.

John F. Hardesty Department of Ophthalmology and Visual Sciences, Washington University School of Medicine in St. Louis, St. Louis, Missouri. Electronic address:

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http://dx.doi.org/10.1016/j.ophtha.2019.04.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756956PMC
October 2019

Elevated Environmental Carbon Dioxide Exposure Confounding Physiologic Events in Aviators?

Mil Med 2019 Apr 30. Epub 2019 Apr 30.

Naval Medical Center, Department of Emergency Medicine, 34800 Bob Wilson Dr., San Diego, CA 92134.

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https://academic.oup.com/milmed/advance-article/doi/10.1093/
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http://dx.doi.org/10.1093/milmed/usz092DOI Listing
April 2019

Combined SIRT3 and SIRT5 deletion is associated with inner retinal dysfunction in a mouse model of type 1 diabetes.

Sci Rep 2019 Mar 7;9(1):3799. Epub 2019 Mar 7.

Department of Ophthalmology & Visual Sciences, Washington University School of Medicine, St. Louis, MO, USA.

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http://dx.doi.org/10.1038/s41598-019-40177-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406004PMC
March 2019

Whole-Body Vibration and Trunk Posture During Operation of Agricultural Machinery.

Ann Work Expo Health 2018 11;62(9):1123-1133

Department of Occupational and Environmental Health, University of Iowa, Suite Iowa City, IA, USA.

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http://dx.doi.org/10.1093/annweh/wxy076DOI Listing
November 2018

Multiplexed Optical Imaging of Energy Substrates Reveals That Left Ventricular Hypertrophy Is Associated With Brown Adipose Tissue Activation.

Circ Cardiovasc Imaging 2018 03;11(3):e007007

From the Cardiovascular Medicine Section, Department of Medicine, Boston University Medical Center, MA (M.P., D.C., I.L., W.S.C.); Cardiovascular Research Center (M.P., H.H.C., D.E.S.) and Martinos Center for Biomedical Imaging, Department of Radiology (M.P., H.H.C., Y.-C.I.C., C.R., L.J., D.E.S.), Massachusetts General Hospital, Boston, MA.

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http://dx.doi.org/10.1161/CIRCIMAGING.117.007007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908227PMC
March 2018

Accuracy of angular displacements and velocities from inertial-based inclinometers.

Appl Ergon 2018 Feb;67:151-161

Department of Occupational and Environmental Health, University of Iowa, Iowa City, IA, USA.

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http://dx.doi.org/10.1016/j.apergo.2017.09.007DOI Listing
February 2018

Characterizing exposure to physical risk factors among reforestation hand planters in the Southeastern United States.

Appl Ergon 2018 Jan 3;66:1-8. Epub 2017 Aug 3.

Department of Industrial and Systems Engineering, Auburn University, 3301 Shelby Center for Engineering Technology, Auburn, AL 36849, USA. Electronic address:

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http://dx.doi.org/10.1016/j.apergo.2017.07.013DOI Listing
January 2018

Theranostic Nucleic Acid Binding Nanoprobe Exerts Anti-inflammatory and Cytoprotective Effects in Ischemic Injury.

Theranostics 2017 8;7(4):814-825. Epub 2017 Feb 8.

Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston MA;; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston MA.

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http://dx.doi.org/10.7150/thno.17366DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381246PMC
October 2017

Molecular Magnetic Resonance Imaging of Lung Fibrogenesis with an Oxyamine-Based Probe.

Angew Chem Int Ed Engl 2017 08 13;56(33):9825-9828. Epub 2017 Jul 13.

A. A. Martinos Center for Biomedical Imaging and the Institute for Innovation in Imaging, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Suite 2301, Charlestown, MA, 02129, USA.

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http://dx.doi.org/10.1002/anie.201704773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558833PMC
August 2017

Usability Evaluation and Implementation of a Health Information Technology Dashboard of Evidence-Based Quality Indicators.

Comput Inform Nurs 2017 Jun;35(6):281-288

Author Affiliations: Department of Industrial and Systems Engineering, Auburn University, Alabama (Dr Schall); Department of Nursing Services and Patient Care, University of Iowa Hospitals and Clinics (Dr Cullen); Departments of Mechanical and Industrial Engineering (Dr Pennathur) and Occupational and Environmental Health (Mr Chen), University of Iowa; and Health Care Information Systems (Mr Burrell) and Department of Nursing Services and Patient Care (Ms Matthews), University of Iowa Hospitals and Clinics, Iowa City.

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http://dx.doi.org/10.1097/CIN.0000000000000325DOI Listing
June 2017

Corrigendum to "Working postures and physical activity among registered nurses" [Appl. Ergon. 54 (2016), 243-250].

Appl Ergon 2016 Sep 6;56:75. Epub 2016 Apr 6.

Department of Occupational and Environmental Health, University of Iowa, Iowa City, IA, USA.

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http://dx.doi.org/10.1016/j.apergo.2016.03.012DOI Listing
September 2016

Microstructural characterization of myocardial infarction with optical coherence tractography and two-photon microscopy.

Physiol Rep 2016 09;4(18)

Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital Harvard Medical School, Charlestown, Massachusetts Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital Harvard Medical School, Charlestown, Massachusetts

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037910PMC
http://dx.doi.org/10.14814/phy2.12894DOI Listing
September 2016

Working postures and physical activity among registered nurses.

Appl Ergon 2016 May 23;54:243-50. Epub 2016 Jan 23.

Department of Occupational and Environmental Health, University of Iowa, Iowa City, IA, USA.

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http://dx.doi.org/10.1016/j.apergo.2016.01.008DOI Listing
May 2016

Accuracy and repeatability of an inertial measurement unit system for field-based occupational studies.

Ergonomics 2016 Apr 7;59(4):591-602. Epub 2015 Oct 7.

d Department of Epidemiology, Human Genetics and Environmental Sciences , University of Texas School of Public Health , San Antonio , TX , USA.

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http://dx.doi.org/10.1080/00140139.2015.1079335DOI Listing
April 2016

Evaluation of four sensor locations for physical activity assessment.

Appl Ergon 2016 Mar 29;53 Pt A:103-9. Epub 2015 Sep 29.

Department of Occupational and Environmental Health, University of Iowa, Iowa City, IA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.apergo.2015.09.007DOI Listing
March 2016

Imaging Lymphoid Cell Death In Vivo During Polymicrobial Sepsis.

Crit Care Med 2015 Nov;43(11):2303-12

1Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA. 2Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA. 3Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA.

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http://dx.doi.org/10.1097/CCM.0000000000001254DOI Listing
November 2015

Heat-Induced Radiolabeling of Nanoparticles for Monocyte Tracking by PET.

Angew Chem Int Ed Engl 2015 Oct 14;54(44):13002-6. Epub 2015 Sep 14.

Center for Advanced Medical Imaging Sciences, Department of Radiology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114 (USA).

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http://dx.doi.org/10.1002/anie.201505525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754124PMC
October 2015

A comparison of instrumentation methods to estimate thoracolumbar motion in field-based occupational studies.

Appl Ergon 2015 May 3;48:224-31. Epub 2015 Jan 3.

Department of Occupational and Environmental Health, College of Public Health, University of Iowa, Iowa City, IA 52242, USA.

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http://dx.doi.org/10.1016/j.apergo.2014.12.005DOI Listing
May 2015

Cytoprotective nanoparticles by conjugation of a polyhis tagged annexin V to a nanoparticle drug.

Nanoscale 2015 Feb;7(6):2255-9

Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA 02129, USA.

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http://dx.doi.org/10.1039/c4nr06861kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312233PMC
February 2015

Quantification of global diastolic function by kinematic modeling-based analysis of transmitral flow via the parametrized diastolic filling formalism.

J Vis Exp 2014 Sep 1(91):e51471. Epub 2014 Sep 1.

Department of Medicine, Cardiovascular Division, Washington University in St. Louis; Cardiovascular Biophysics Lab, Washington University in St. Louis;

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http://dx.doi.org/10.3791/51471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4828027PMC
September 2014

Microstructural impact of ischemia and bone marrow-derived cell therapy revealed with diffusion tensor magnetic resonance imaging tractography of the heart in vivo.

Circulation 2014 Apr 11;129(17):1731-41. Epub 2014 Mar 11.

From Martinos Center for Biomedical Imaging, Department of Radiology (D.E.S., C.M., S.H., H.H.C., G.D., R.W., W.J.K., V.J.W.), and Cardiovascular Research Center, Cardiology Division (D.E.S., H.H.C., W.J.K.), Massachusetts General Hospital, Harvard Medical School, Boston, MA; Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland (C.T.S., S.K.); Cardiac Muscle Research Laboratory, Divisions of Cardiology and Genetics, Brigham and Woman's Hospital, Harvard Medical School, Boston, MA (S.N., J.G., R.L.); and Department of Computer Science, Institute of Mathematics and Statistics, University of São Paulo, São Paulo, Brazil (M.P.J.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.113.005841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034455PMC
April 2014

Role of extracellular RNA and TLR3-Trif signaling in myocardial ischemia-reperfusion injury.

J Am Heart Assoc 2014 Jan 3;3(1):e000683. Epub 2014 Jan 3.

Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital.

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http://dx.doi.org/10.1161/JAHA.113.000683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959703PMC
January 2014

Molecular magnetic resonance imaging of pulmonary fibrosis in mice.

Am J Respir Cell Mol Biol 2013 Dec;49(6):1120-6

1 A. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts.

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http://dx.doi.org/10.1165/rcmb.2013-0039OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931113PMC
December 2013

Fluorescent and radiolabeled triphenylphosphonium probes for imaging mitochondria.

Chem Commun (Camb) 2013 Nov;49(88):10361-3

Center for Advanced Medical Imaging Sciences, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1039/c3cc45802dDOI Listing
November 2013

Characterization of printable cellular micro-fluidic channels for tissue engineering.

Biofabrication 2013 Jun 5;5(2):025004. Epub 2013 Mar 5.

Mechanical and Industrial Engineering Department, The University of Iowa, Iowa City, IA, USA.

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http://stacks.iop.org/1758-5090/5/i=2/a=025004?key=crossref.
Publisher Site
http://dx.doi.org/10.1088/1758-5082/5/2/025004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281173PMC
June 2013

Adult cardiac progenitor cell aggregates exhibit survival benefit both in vitro and in vivo.

PLoS One 2012 30;7(11):e50491. Epub 2012 Nov 30.

Division of Cardiology and Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0050491PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511575PMC
May 2013

Fluorescence tomography of rapamycin-induced autophagy and cardioprotection in vivo.

Circ Cardiovasc Imaging 2013 May 28;6(3):441-7. Epub 2013 Mar 28.

Martinos Center for Biomedical Imaging, Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1161/CIRCIMAGING.112.000074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805276PMC
May 2013

Fluorochrome-functionalized nanoparticles for imaging DNA in biological systems.

ACS Nano 2013 Mar 7;7(3):2032-41. Epub 2013 Feb 7.

Center for Translational Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, United States.

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http://dx.doi.org/10.1021/nn305962nDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800685PMC
March 2013

Thrombotic thrombocytopenic purpura in pediatric patients.

Zhongguo Dang Dai Er Ke Za Zhi 2012 Nov;14(11):803-10

Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.

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November 2012

Theranostic Imaging of the Kinases and Proteases that Modulate Cell Death and Survival.

Theranostics 2012 8;2(2):148-55. Epub 2012 Feb 8.

1. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston MA.

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http://www.thno.org/v02p0148.htm
Publisher Site
http://dx.doi.org/10.7150/thno.4077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296472PMC
October 2012

Fluorochrome-functionalized magnetic nanoparticles for high-sensitivity monitoring of the polymerase chain reaction by magnetic resonance.

Angew Chem Int Ed Engl 2012 Jul 8;51(28):6904-7. Epub 2012 Jun 8.

Center for Translational Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, Charlestown, 02129, USA.

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http://dx.doi.org/10.1002/anie.201201661DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477829PMC
July 2012

In vivo fluorescence lifetime detection of an activatable probe in infarcted myocardium.

J Biomed Opt 2012 May;17(5):056001

Harvard Medical School, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1117/1.JBO.17.5.056001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381023PMC
May 2012

Protective effect of the apoptosis-sensing nanoparticle AnxCLIO-Cy5.5.

Nanomedicine 2012 Apr 24;8(3):291-8. Epub 2011 Jun 24.

Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S154996341100265
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http://dx.doi.org/10.1016/j.nano.2011.06.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319055PMC
April 2012

Comparison of aneuploidies of chromosomes 21, X, and Y in the blood lymphocytes and sperm of workers exposed to benzene.

Environ Mol Mutagen 2012 Apr 20;53(3):218-26. Epub 2012 Feb 20.

Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, California, USA.

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http://dx.doi.org/10.1002/em.21683DOI Listing
April 2012

Molecular MRI of acute necrosis with a novel DNA-binding gadolinium chelate: kinetics of cell death and clearance in infarcted myocardium.

Circ Cardiovasc Imaging 2011 Nov 11;4(6):729-37. Epub 2011 Aug 11.

Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1161/CIRCIMAGING.111.966374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370828PMC
November 2011

Myocardial ischemia activates an injurious innate immune signaling via cardiac heat shock protein 60 and Toll-like receptor 4.

J Biol Chem 2011 Sep 20;286(36):31308-19. Epub 2011 Jul 20.

Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1074/jbc.M111.246124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173057PMC
September 2011

Imaging of apoptosis in the heart with nanoparticle technology.

Wiley Interdiscip Rev Nanomed Nanobiotechnol 2011 Jan-Feb;3(1):86-99

Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.

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http://doi.wiley.com/10.1002/wnan.115
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http://dx.doi.org/10.1002/wnan.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3086683PMC
July 2011

Therapeutic potential of histamine H3 receptor agonist for the treatment of obesity and diabetes mellitus.

Proc Natl Acad Sci U S A 2006 Sep 5;103(37):13866-71. Epub 2006 Sep 5.

Tsukuba Research Institute, Banyu Pharmaceutical Company, Ltd., Tsukuba, Ibaraki 300-2611, Japan.

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http://dx.doi.org/10.1073/pnas.0506104103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1560086PMC
September 2006

Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonists.

J Biol Chem 2006 Feb 2;281(5):2654-60. Epub 2005 Dec 2.

Department of Cell Biology, Division of Endocrinology, and Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M505311200
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http://dx.doi.org/10.1074/jbc.M505311200DOI Listing
February 2006

Sherrington innervational surgery in the treatment of chronic sixth nerve paresis.

Binocul Vis Strabismus Q 2005 ;20(3):159-66

Yale University of School of Medicine Department of Opthamology, New Haven, CT 06520-8061, USA.

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January 2006

Diet induction of monocyte chemoattractant protein-1 and its impact on obesity.

Obes Res 2005 Aug;13(8):1311-20

Department of Metabolic Disorders, Merck Research Laboratories, Rahway, NJ 07065, USA.

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http://dx.doi.org/10.1038/oby.2005.159DOI Listing
August 2005

Somatostatin receptor subtype 5 regulates insulin secretion and glucose homeostasis.

Mol Endocrinol 2003 Jan;17(1):93-106

Department of Molecular Endocrinology, Merck Research Laboratories, Rahway, New Jersey 07065, USA.

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http://dx.doi.org/10.1210/me.2001-0035DOI Listing
January 2003