Hovhannes Gukasyan

Hovhannes Gukasyan

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Hovhannes Gukasyan

Hovhannes Gukasyan

Publications by authors named "Hovhannes Gukasyan"

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37Publications

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Ocular biopharmaceutics: impact of modeling and simulation on topical ophthalmic formulation development.

Drug Discov Today 2019 08 5;24(8):1587-1597. Epub 2019 Apr 5.

Early Pharmaceutical Development, Allergan plc, 2525 Dupont Drive, Irvine, CA, 92612, United States.

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http://dx.doi.org/10.1016/j.drudis.2019.04.002DOI Listing
August 2019

Ophthalmic Drug Discovery and Development.

Pharm Res 2019 03 18;36(5):69. Epub 2019 Mar 18.

Allergan plc., Pharmaceutical Development, Irvine, California, USA.

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http://dx.doi.org/10.1007/s11095-019-2606-7DOI Listing
March 2019

Safety Assessment of Formulation Vehicles Following Intravitreal Administration in Rabbits.

Pharm Res 2018 Jul 9;35(9):173. Epub 2018 Jul 9.

Pfizer Inc., Drug Safety Research and Development, La Jolla Laboratories, 10646 Science Center Drive, San Diego, CA, 92121, USA.

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http://dx.doi.org/10.1007/s11095-018-2450-1DOI Listing
July 2018

Oligopeptide Transport in Rat Lung Alveolar Epithelial Cells is Mediated by Pept2.

Pharm Res 2017 Dec 22;34(12):2488-2497. Epub 2017 Aug 22.

Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California, USA.

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http://dx.doi.org/10.1007/s11095-017-2234-zDOI Listing
December 2017

Axitinib inhibits retinal and choroidal neovascularization in in vitro and in vivo models.

Exp Eye Res 2016 04 27;145:373-379. Epub 2016 Feb 27.

Global Science and Technology-WCM, Pfizer Inc., 10724 Science Center Drive, San Diego, CA 92121, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00144835163002
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http://dx.doi.org/10.1016/j.exer.2016.02.010DOI Listing
April 2016

Antibody-Drug Conjugates.

Pharm Res 2015 Nov 15;32(11):3451-2. Epub 2015 Aug 15.

Pfizer Inc, San Diego, CA, USA.

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http://dx.doi.org/10.1007/s11095-015-1775-2DOI Listing
November 2015

Design, synthesis, and evaluation of NO-donor containing carbonic anhydrase inhibitors to lower intraocular pressure.

J Med Chem 2015 Mar 6;58(6):2821-33. Epub 2015 Mar 6.

La Jolla Laboratories, Pfizer Worldwide Research and Development, 10770 Science Center Drive, San Diego, California 92121, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.5b00043DOI Listing
March 2015

An assessment of the ocular safety of excipient maleic acid following intravitreal injection in rabbits.

Toxicol Pathol 2012 Jul 2;40(5):797-806. Epub 2012 May 2.

Drug Safety Research and Development, La Jolla Laboratories, Pfizer Inc., San Diego, California, USA.

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http://dx.doi.org/10.1177/0192623312441400DOI Listing
July 2012

Pharmacokinetic study of vitreous and serum concentrations of triamcinolone acetonide after posterior sub-tenon's injection.

Am J Ophthalmol 2012 May 4;153(5):939-48. Epub 2012 Feb 4.

Beth Israel Deaconess Medical Center, Division of Ophthalmology, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1016/j.ajo.2011.10.021DOI Listing
May 2012

Solution formulation development of a VEGF inhibitor for intravitreal injection.

AAPS PharmSciTech 2011 Mar 11;12(1):362-71. Epub 2011 Feb 11.

Research Enabling Group, Pfizer Inc, 10777 Science Center Drive, San Diego, California 92121, USA.

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http://dx.doi.org/10.1208/s12249-011-9591-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066352PMC
March 2011

L-Carnosine: multifunctional dipeptide buffer for sustained-duration topical ophthalmic formulations.

J Pharm Pharmacol 2009 Jun;61(6):733-42

Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska, USA.

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http://dx.doi.org/10.1211/jpp/61.06.0005DOI Listing
June 2009

Correlation of in vitro and in vivo kinetics of nitric oxide donors in ocular tissues.

J Ocul Pharmacol Ther 2009 Apr;25(2):105-12

Department of Ocular Biology, Pfizer Global Research and Development, La Jolla Laboratories, San Diego, California, USA.

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http://dx.doi.org/10.1089/jop.2008.0091DOI Listing
April 2009

An assessment of the ocular safety of inactive excipients following sub-tenon injection in rabbits.

J Ocul Pharmacol Ther 2008 Apr;24(2):206-16

Drug Safety Research and Development, Pfizer Global Research and Development, La Jolla Laboratories, San Diego, CA 92121, USA.

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http://dx.doi.org/10.1089/jop.2007.0099DOI Listing
April 2008

Functional characterization and cloning of amino acid transporter B(0,+) (ATB(0,+)) in primary cultured rat pneumocytes.

J Cell Physiol 2008 Mar;214(3):645-54

First Department of Biochemistry, Kyushu University of Health and Welfare, Nobeoka, Miyazaki, Japan.

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http://dx.doi.org/10.1002/jcp.21254DOI Listing
March 2008

Transepithelial bioelectrical properties of rabbit acinar cell monolayers on polyester membrane scaffolds.

Am J Physiol Cell Physiol 2007 Oct 15;293(4):C1412-9. Epub 2007 Aug 15.

Mork Family Department of Chemical Engineering and Materials Science, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, USA.

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http://www.physiology.org/doi/10.1152/ajpcell.00200.2007
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http://dx.doi.org/10.1152/ajpcell.00200.2007DOI Listing
October 2007

Glutathione and its transporters in ocular surface defense.

Ocul Surf 2007 Oct;5(4):269-79

department of Pharmaceutical Sciences, School of Medicine, University of Southern California, Los Angeles, CA 90089-9224, USA.

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http://dx.doi.org/10.1016/s1542-0124(12)70093-9DOI Listing
October 2007

Ocular disposition, pharmacokinetics, efficacy and safety of nanoparticle-formulated ophthalmic drugs.

Curr Drug Metab 2007 Feb;8(2):91-107

Department of Pharmacokinetics, Dynamics and Metabolism, PGRD, San Diego, CA 92121, USA.

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http://dx.doi.org/10.2174/138920007779815977DOI Listing
February 2007

2nd Ophthalmic Drug Development and Delivery Summit.

Expert Opin Drug Deliv 2007 Jan;4(1):77-85

Research Formulations, Science & Technology, Pfizer Global R&D, La Jolla Laboratories, Pfizer, Inc., San Diego CA 92121, USA.

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http://dx.doi.org/10.1517/17425247.4.1.77DOI Listing
January 2007

Thermodynamic stoichiometry of Na+-coupled glutathione transport.

Can J Physiol Pharmacol 2006 Nov;84(11):1223-7

Department of Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA.

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http://dx.doi.org/10.1139/y06-067DOI Listing
November 2006

Tissue distribution of moxaverine-hydrochloride in the rabbit eye and plasma.

J Ocul Pharmacol Ther 2005 Jun;21(3):210-6

Saarland University, Department of Biopharmaceutics and Pharmaceutical Technology, Saarbrücken, Germany.

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http://dx.doi.org/10.1089/jop.2005.21.210DOI Listing
June 2005

Impairment of conjunctival glutathione secretion and ion transport by oxidative stress in an adenovirus type 5 ocular infection model of pigmented rabbits.

Free Radic Biol Med 2004 Jul;37(2):229-38

Doheny Eye Institute, Schools of Pharmacy, Medicine, and Engineering, University of Southern California, Los Angeles 90089, USA.

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http://dx.doi.org/10.1016/j.freeradbiomed.2004.04.030DOI Listing
July 2004

Specialized protective role of mucosal glutathione in pigmented rabbit conjunctiva.

Invest Ophthalmol Vis Sci 2003 Oct;44(10):4427-38

Departments of Pharmaceutical Sciences, University of Southern California, Los Angeles, California 90089, USA.

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http://dx.doi.org/10.1167/iovs.03-0437DOI Listing
October 2003

Clathrin and caveolin-1 expression in primary pigmented rabbit conjunctival epithelial cells: role in PLGA nanoparticle endocytosis.

Mol Vis 2003 Oct 15;9:559-68. Epub 2003 Oct 15.

Department of Pharmaceutical Sciences, University of Southern California, Los Angeles, CA 90033-9121, USA.

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October 2003

Nucleotide-induced restoration of conjunctival chloride and fluid secretion in adenovirus type 5-infected pigmented rabbit eyes.

J Pharmacol Exp Ther 2003 Jun 20;305(3):1206-11. Epub 2003 Mar 20.

Department of Pharmaceutical Sciences, School of Pharmacy, 1985 Zonal Ave., University of Southern California, Los Angeles, CA 90089-9121, USA.

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http://dx.doi.org/10.1124/jpet.103.049221DOI Listing
June 2003

Metabolism and transport of purinergic receptor agonists in rabbit conjunctival epithelial cells.

Adv Exp Med Biol 2002 ;506(Pt A):255-9

Department of Pharmaceutical Sciences, University of Southern California, Los Angeles, California, USA.

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http://dx.doi.org/10.1007/978-1-4615-0717-8_35DOI Listing
May 2003

Regulation of L-cystine transport and intracellular GSH level by a nitric oxide donor in primary cultured rabbit conjunctival epithelial cell layers.

Invest Ophthalmol Vis Sci 2003 Mar;44(3):1202-10

Department of Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California, USA.

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http://dx.doi.org/10.1167/iovs.02-0409DOI Listing
March 2003

Characterization of cyclic AMP-regulated chloride conductance in the pigmented rabbit conjunctival epithelial cells.

Can J Physiol Pharmacol 2002 Jun;80(6):533-40

Department of Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles 90089-9121, USA.

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http://dx.doi.org/10.1139/y02-066DOI Listing
June 2002

Net glutathione secretion across primary cultured rabbit conjunctival epithelial cell layers.

Invest Ophthalmol Vis Sci 2002 Apr;43(4):1154-61

Department of Pharmaceutical Sciences, University of Southern California, Los Angeles, California 90033, USA.

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April 2002