Hossein-Ardeschir Ghofrani

Hossein-Ardeschir Ghofrani

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Hossein-Ardeschir Ghofrani

Hossein-Ardeschir Ghofrani

Publications by authors named "Hossein-Ardeschir Ghofrani"

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FHL-1 is not involved in pressure overload-induced maladaptive right ventricular remodeling and dysfunction.

Basic Res Cardiol 2020 01 24;115(2):17. Epub 2020 Jan 24.

Member of the German Center for Lung Research (DZL), Excellence Cluster Cardio-Pulmonary System (ECCPS), Universities of Giessen and Marburg Lung Center (UGMLC), Justus-Liebig-University Giessen, Aulweg 130, 35392, Giessen, Germany.

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http://dx.doi.org/10.1007/s00395-019-0767-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981327PMC
January 2020

Risk assessment in pulmonary arterial hypertension: Insights from the GRIPHON study.

J Heart Lung Transplant 2020 Jan 21. Epub 2020 Jan 21.

Department of Respiratory Medicine and German Center of Lung Research, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1016/j.healun.2019.12.013DOI Listing
January 2020

Right heart failure in pulmonary hypertension: Diagnosis and new perspectives on vascular and direct right ventricular treatment.

Br J Pharmacol 2019 Sep 13. Epub 2019 Sep 13.

Department of Pulmonary Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1111/bph.14866DOI Listing
September 2019

Severe Emphysema in the SU5416/Hypoxia Rat Model of Pulmonary Hypertension.

Am J Respir Crit Care Med 2019 Aug;200(4):515-518

1Justus Liebig University of Giessen, member of the German Center for Lung ResearchGiessen, Germanyand.

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http://dx.doi.org/10.1164/rccm.201902-0390LEDOI Listing
August 2019

Cardiopulmonary haemodynamics in portopulmonary hypertension.

Lancet Respir Med 2019 Jul 6;7(7):556-558. Epub 2019 Jun 6.

Department of Internal Medicine, Pulmonary Hypertension Division, University of Giessen and Marburg Lung Center, Giessen 35392, Germany; Department of Medicine, Imperial College London, London, UK. Electronic address:

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http://dx.doi.org/10.1016/S2213-2600(19)30143-2DOI Listing
July 2019

Risk assessment in pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension.

Eur Respir J 2019 Jun 5;53(6). Epub 2019 Jun 5.

Clinic for Respiratory Medicine, Hannover Medical School, Member of the German Center for Lung Research (DZL), Hannover, Germany.

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http://dx.doi.org/10.1183/13993003.02004-2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551213PMC
June 2019

Subcutaneous treprostinil: a new treatment for chronic thromboembolic pulmonary hypertension?

Lancet Respir Med 2019 Mar 23;7(3):191-193. Epub 2018 Nov 23.

Department of Internal Medicine, Pulmonary Hypertension Division, University of Giessen and Marburg Lung Center, 35392 Giessen, Germany; Department of Medicine, Imperial College London, London, UK. Electronic address:

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http://dx.doi.org/10.1016/S2213-2600(18)30369-2DOI Listing
March 2019

Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis.

Authors:
Christopher J Rhodes Ken Batai Marta Bleda Matthias Haimel Laura Southgate Marine Germain Michael W Pauciulo Charaka Hadinnapola Jurjan Aman Barbara Girerd Amit Arora Jo Knight Ken B Hanscombe Jason H Karnes Marika Kaakinen Henning Gall Anna Ulrich Lars Harbaum Inês Cebola Jorge Ferrer Katie Lutz Emilia M Swietlik Ferhaan Ahmad Philippe Amouyel Stephen L Archer Rahul Argula Eric D Austin David Badesch Sahil Bakshi Christopher Barnett Raymond Benza Nitin Bhatt Harm J Bogaard Charles D Burger Murali Chakinala Colin Church John G Coghlan Robin Condliffe Paul A Corris Cesare Danesino Stéphanie Debette C Gregory Elliott Jean Elwing Melanie Eyries Terry Fortin Andre Franke Robert P Frantz Adaani Frost Joe G N Garcia Stefano Ghio Hossein-Ardeschir Ghofrani J Simon R Gibbs John Harley Hua He Nicholas S Hill Russel Hirsch Arjan C Houweling Luke S Howard Dunbar Ivy David G Kiely James Klinger Gabor Kovacs Tim Lahm Matthias Laudes Rajiv D Machado Robert V MacKenzie Ross Keith Marsolo Lisa J Martin Shahin Moledina David Montani Steven D Nathan Michael Newnham Andrea Olschewski Horst Olschewski Ronald J Oudiz Willem H Ouwehand Andrew J Peacock Joanna Pepke-Zaba Zia Rehman Ivan Robbins Dan M Roden Erika B Rosenzweig Ghulam Saydain Laura Scelsi Robert Schilz Werner Seeger Christian M Shaffer Robert W Simms Marc Simon Olivier Sitbon Jay Suntharalingam Haiyang Tang Alexander Y Tchourbanov Thenappan Thenappan Fernando Torres Mark R Toshner Carmen M Treacy Anton Vonk Noordegraaf Quinten Waisfisz Anna K Walsworth Robert E Walter John Wharton R James White Jeffrey Wilt Stephen J Wort Delphine Yung Allan Lawrie Marc Humbert Florent Soubrier David-Alexandre Trégouët Inga Prokopenko Richard Kittles Stefan Gräf William C Nichols Richard C Trembath Ankit A Desai Nicholas W Morrell Martin R Wilkins

Lancet Respir Med 2019 Mar 5;7(3):227-238. Epub 2018 Dec 5.

Department of Medicine, Imperial College London, London, UK. Electronic address:

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http://dx.doi.org/10.1016/S2213-2600(18)30409-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391516PMC
March 2019

Evaluating Systolic and Diastolic Cardiac Function in Rodents Using Microscopic Computed Tomography.

Circ Cardiovasc Imaging 2018 12;11(12):e007653

German Center for Lung Research (DZL), Justus-Liebig University of Giessen, Universities of Giessen and Marburg Lung Center (UGMLC), Giessen, Germany (B.K., J.W., M.K., H.A.G., F.G., N.W., W.S., R.T.S.).

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http://dx.doi.org/10.1161/CIRCIMAGING.118.007653DOI Listing
December 2018

More on Single-Beat Estimation of Right Ventriculoarterial Coupling in Pulmonary Arterial Hypertension.

Am J Respir Crit Care Med 2018 09;198(6):816-818

1 Universities of Giessen and Marburg Lung Centre, member of the German Centre for Lung Research Giessen, Germany.

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http://dx.doi.org/10.1164/rccm.201802-0283LEDOI Listing
September 2018

Nintedanib in Severe Pulmonary Arterial Hypertension.

Am J Respir Crit Care Med 2018 09;198(6):808-810

1 Universities of Giessen and Marburg Lung Centre, member of the German Centre for Lung Research Giessen, Germany.

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http://dx.doi.org/10.1164/rccm.201801-0195LEDOI Listing
September 2018

Hypoxic pulmonary vasoconstriction in isolated mouse pulmonary arterial vessels.

Exp Physiol 2018 09 6;103(9):1185-1191. Epub 2018 Jul 6.

Excellence Cluster Cardiopulmonary System, German Center for Lung Research (DZL), Justus Liebig University Giessen, Giessen, Germany.

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http://dx.doi.org/10.1113/EP087117DOI Listing
September 2018

Switching inhaled iloprost formulations in patients with pulmonary arterial hypertension: the VENTASWITCH Trial.

Pulm Circ 2018 Oct-Dec;8(4):2045894018798921. Epub 2018 Aug 20.

1 Department of Internal Medicine, Justus Liebig University Giessen, Universities of Giessen and Marburg Lung Center (UGMLC), member of the German Center for Lung Research (DZL), Giessen, Germany.

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http://dx.doi.org/10.1177/2045894018798921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128078PMC
August 2018

REVEAL risk score in patients with chronic thromboembolic pulmonary hypertension receiving riociguat.

J Heart Lung Transplant 2018 07 1;37(7):836-843. Epub 2018 Mar 1.

University of Giessen and Marburg Lung Center, member of the German Center for Lung Research (DZL), Giessen, Germany; Department of Medicine, Imperial College London, London, UK.

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http://dx.doi.org/10.1016/j.healun.2018.02.015DOI Listing
July 2018

REVEAL risk scores applied to riociguat-treated patients in PATENT-2: Impact of changes in risk score on survival.

J Heart Lung Transplant 2018 04 11;37(4):513-519. Epub 2017 Nov 11.

Clinic for Respiratory Medicine, Hannover Medical School, member of the German Center of Lung Research, Hannover, Germany.

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http://dx.doi.org/10.1016/j.healun.2017.11.006DOI Listing
April 2018

Thin Air Resulting in High Pressure: Mountain Sickness and Hypoxia-Induced Pulmonary Hypertension.

Can Respir J 2017 27;2017:8381653. Epub 2017 Mar 27.

Department of Internal Medicine, Justus Liebig University Giessen, Universities of Giessen and Marburg Lung Center (UGMLC), Klinikstrasse 33, 35392 Giessen, Germany.

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http://dx.doi.org/10.1155/2017/8381653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385916PMC
March 2018

Intravenous treprostinil infusion via a fully implantable pump for pulmonary arterial hypertension.

Clin Res Cardiol 2017 Oct 20;106(10):776-783. Epub 2017 Apr 20.

Department of Pneumology, Kerckhoff Heart and Thoracic Center, Bad Nauheim, Germany.

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http://dx.doi.org/10.1007/s00392-017-1114-1DOI Listing
October 2017

Plasma MMP2/TIMP4 Ratio at Follow-up Assessment Predicts Disease Progression of Idiopathic Pulmonary Arterial Hypertension.

Lung 2017 08 17;195(4):489-496. Epub 2017 May 17.

University of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Giessen, Germany.

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http://dx.doi.org/10.1007/s00408-017-0014-5DOI Listing
August 2017

Individual dose adjustment of riociguat in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension.

Respir Med 2017 08 15;129:124-129. Epub 2017 May 15.

University of Giessen and Marburg Lung Center, Giessen, Germany, Member of the German Center of Lung Research (DZL); Department of Medicine, Imperial College London, London, UK.

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http://dx.doi.org/10.1016/j.rmed.2017.05.005DOI Listing
August 2017

Riociguat for pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension: Results from a phase II long-term extension study.

Respir Med 2017 07 16;128:50-56. Epub 2017 May 16.

University of Giessen and Marburg Lung Center (UGMLC), Giessen, Germany, Member of the German Center of Lung Research (DZL). Electronic address:

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http://dx.doi.org/10.1016/j.rmed.2017.05.008DOI Listing
July 2017

Circulating Angiopoietin-1 Is Not a Biomarker of Disease Severity or Prognosis in Pulmonary Hypertension.

PLoS One 2016 1;11(11):e0165982. Epub 2016 Nov 1.

Department of Internal Medicine, Justus-Liebig-University Giessen, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Giessen, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0165982PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5089726PMC
June 2017

The Role of Transient Receptor Potential Channel 6 Channels in the Pulmonary Vasculature.

Front Immunol 2017 16;8:707. Epub 2017 Jun 16.

Excellence Cluster Cardio-Pulmonary System, Universities of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), Justus Liebig University of Giessen, Giessen, Germany.

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http://dx.doi.org/10.3389/fimmu.2017.00707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472666PMC
June 2017

Comparison of hemodynamic parameters in treatment-naïve and pre-treated patients with pulmonary arterial hypertension in the randomized phase III PATENT-1 study.

J Heart Lung Transplant 2017 May 24;36(5):509-519. Epub 2016 Dec 24.

University of Giessen and Marburg Lung Center, member of German Center for Lung Research, Giessen, Germany; Department of Medicine, Imperial College London, London, United Kingdom.

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http://dx.doi.org/10.1016/j.healun.2016.12.012DOI Listing
May 2017

Procedural safety of a fully implantable intravenous prostanoid pump for pulmonary hypertension.

Clin Res Cardiol 2017 Mar 26;106(3):174-182. Epub 2016 Sep 26.

Department of Pneumology, Kerckhoff Heart and Thoracic Center, Bad Nauheim, Germany.

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http://dx.doi.org/10.1007/s00392-016-1037-2DOI Listing
March 2017

Medical management of chronic thromboembolic pulmonary hypertension.

Eur Respir Rev 2017 Mar 29;26(143). Epub 2017 Mar 29.

Dept of Respiratory Medicine, Hannover Medical School and Center for Lung Research, Hannover, Germany.

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http://dx.doi.org/10.1183/16000617.0107-2016DOI Listing
March 2017

Balloon pulmonary angioplasty in chronic thromboembolic pulmonary hypertension.

Eur Respir Rev 2017 Mar 29;26(143). Epub 2017 Mar 29.

Hôpital Marie Lannelongue, Le Plessis-Robinson, France.

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http://dx.doi.org/10.1183/16000617.0119-2016DOI Listing
March 2017

Riociguat: Mode of Action and Clinical Development in Pulmonary Hypertension.

Chest 2017 02 2;151(2):468-480. Epub 2016 Jun 2.

Division of Pulmonary, Sleep, and Critical Care Medicine, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI.

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http://dx.doi.org/10.1016/j.chest.2016.05.024DOI Listing
February 2017

Pulmonary Hypertension.

Dtsch Arztebl Int 2017 02;114(5):73-84

Department of Pneumology, Hannover Medical School; German Center for Lung Research (DZL); Universities of Gießen and Marburg Lung Center (UGMLC), Gießen; Department of Pneumology, Kerckhoff Hospital Bad Nauheim; Department of Medicine, Imperial College, London, UK; Center for Pulmonary Hypertension, Chest Hospital, University Hospital Heidelberg; Pneumology Section, Center for Pulmonary Hypertension Hamburg, University Hospital Hamburg-Eppendorf; Department of Pneumology, University Hospital Graz; Department of Internal Medicine III and Cologne Cardiovascular Research Center (CCRC), Cardiac Center, University of Cologne.

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http://dx.doi.org/10.3238/arztebl.2017.0073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331483PMC
February 2017

Macitentan Improves Health-Related Quality of Life for Patients With Pulmonary Arterial Hypertension: Results From the Randomized Controlled SERAPHIN Trial.

Chest 2017 Jan 23;151(1):106-118. Epub 2016 Sep 23.

Assistance Publique-Hôpitaux de Paris, Service de Pneumologie, Hôpital Bicêtre, Le Kremlin-Bicêtre, France; Université Paris-Sud, Laboratoire d'Excellence en Recherche sur le Médicament et Innovation Thérapeutique, Le Kremlin-Bicêtre, France, and INSERM U-999, Centre chirurgical Marie Lannelongue, Le Plessis Robinson, France.

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http://dx.doi.org/10.1016/j.chest.2016.08.1473DOI Listing
January 2017

Biomarkers of tissue remodeling predict survival in patients with pulmonary hypertension.

Int J Cardiol 2016 Nov 13;223:821-826. Epub 2016 Aug 13.

University of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Giessen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2016.08.240DOI Listing
November 2016

Notch1 signalling regulates endothelial proliferation and apoptosis in pulmonary arterial hypertension.

Eur Respir J 2016 10 28;48(4):1137-1149. Epub 2016 Jul 28.

Universities of Giessen and Marburg Lung Center, Member of the German Center for Lung Research (DZL), Giessen, Germany

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http://dx.doi.org/10.1183/13993003.00773-2015DOI Listing
October 2016

Selexipag for the treatment of pulmonary arterial hypertension.

Expert Opin Pharmacother 2016 Sep 2;17(13):1825-34. Epub 2016 Aug 2.

a Department of Internal Medicine , University of Giessen and Marburg Lung Center (UGMLC) , Giessen , Germany, member of the German Center of Lung Research (DZL).

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http://dx.doi.org/10.1080/14656566.2016.1215429DOI Listing
September 2016

miR-223-IGF-IR signalling in hypoxia- and load-induced right-ventricular failure: a novel therapeutic approach.

Cardiovasc Res 2016 08 24;111(3):184-93. Epub 2016 Mar 24.

Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe-University, Frankfurt am Main, and German Center of Cardiovascular Research (DZHK), Partner site RheinMain, Frankfurt am Main, Germany

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http://dx.doi.org/10.1093/cvr/cvw065DOI Listing
August 2016

The Clinical Significance of HbA1c in Operable Chronic Thromboembolic Pulmonary Hypertension.

PLoS One 2016 31;11(3):e0152580. Epub 2016 Mar 31.

Department of Internal Medicine, Justus-Liebig-University Giessen, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Giessen, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0152580PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816563PMC
August 2016

Quality of life in patients with chronic thromboembolic pulmonary hypertension.

Eur Respir J 2016 08 13;48(2):526-37. Epub 2016 Apr 13.

Assistance Publique-Hôpitaux de Paris, Service de Pneumologie, Hôpital Bicêtre, Université Paris-Sud, Laboratoire d'Excellence en Recherche sur le Médicament et Innovation Thérapeutique, and INSERM Unité 999, Le Kremlin-Bicêtre, France.

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http://dx.doi.org/10.1183/13993003.01626-2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967564PMC
August 2016

Soluble guanylate cyclase stimulator riociguat and phosphodiesterase 5 inhibitor sildenafil ameliorate pulmonary hypertension due to left heart disease in mice.

Int J Cardiol 2016 Aug 16;216:85-91. Epub 2016 Apr 16.

Excellence Cluster Cardio-Pulmonary System, Universities of Giessen and Marburg Lung Center, Member of the German Lung Center, Justus Liebig University Giessen, Giessen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2016.04.098DOI Listing
August 2016

COPD-associated pulmonary hypertension: clinical implications and current methods for treatment.

Expert Rev Respir Med 2016 07 7;10(7):755-66. Epub 2016 Jun 7.

a University of Giessen and Marburg Lung Center (UGMLC), University of Giessen , Giessen , Germany.

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http://dx.doi.org/10.1080/17476348.2016.1190275DOI Listing
July 2016

Cigarette Smoke-Induced Emphysema and Pulmonary Hypertension Can Be Prevented by Phosphodiesterase 4 and 5 Inhibition in Mice.

PLoS One 2015 9;10(6):e0129327. Epub 2015 Jun 9.

Universities of Giessen and Marburg Lung Center (UGMLC), Excellence Cluster Cardio-Pulmonary System (ECCPS), Member of the German Center for Lung Research (DZL), Giessen, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0129327PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461257PMC
May 2016

Predictors of long-term outcomes in patients treated with riociguat for pulmonary arterial hypertension: data from the PATENT-2 open-label, randomised, long-term extension trial.

Lancet Respir Med 2016 05 8;4(5):361-71. Epub 2016 Apr 8.

Université Paris-Sud, Université Paris-Saclay, Le Kremlin Bicêtre, France; AP-HP, Service de Pneumologie, Hôpital Bicêtre, Le Kremlin Bicêtre, France; Inserm UMR_S 999, Hôpital Marie Lannelongue, Le Plessis Robinson, France.

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http://dx.doi.org/10.1016/S2213-2600(16)30019-4DOI Listing
May 2016

The molecular targets of approved treatments for pulmonary arterial hypertension.

Thorax 2016 Jan 28;71(1):73-83. Epub 2015 Jul 28.

University of Giessen and Marburg Lung Center (UGMLC), member of the German Center of Lung Research (DZL), Giessen, Germany Department of Medicine, Imperial College London, London, UK.

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http://dx.doi.org/10.1136/thoraxjnl-2015-207170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4717417PMC
January 2016

Prolonged vasodilatory response to nanoencapsulated sildenafil in pulmonary hypertension.

Nanomedicine 2016 Jan 21;12(1):63-8. Epub 2015 Sep 21.

Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Lung Center (DZL), Justus-Liebig-Universität, Giessen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.nano.2015.08.009DOI Listing
January 2016

Selexipag for the Treatment of Pulmonary Arterial Hypertension.

N Engl J Med 2015 Dec;373(26):2522-33

From Assistance Publique-Hôpitaux de Paris, Hôpital de Bicêtre, INSERM Unité Mixte de Recherche en Santé 999, Université Paris-Sud, Université Paris-Saclay, Le Kremlin-Bicêtre, France (O.S., G.S.); Massachusetts General Hospital, Boston (R.C.); UT Southwestern Medical Center, Dallas (K.M.C.); Actelion Pharmaceuticals, Allschwil, Switzerland (A.F., R.P., L.D.S.); National Pulmonary Hypertension Unit, Mater Misericordiae University Hospital, Dublin (S.G.); the Department of Experimental, Diagnostic and Specialty Medicine (DIMES) University of Bologna, Bologna, Italy (N.G.); University of Giessen and Marburg Lung Center, German Center of Lung Research, Giessen (H.-A.G), and the Department of Respiratory Medicine, Hannover Medical School and German Center of Lung Research, Hannover (M.M.H.) - both in Germany; the Department of Medicine, Imperial College London, London (H.-A.G.); Medical University of Vienna, Department of Internal Medicine II, Division of Cardiology, Allgemeines Krankenhaus, Vienna (I.M.L.); the Division of Pulmonary and Critical Care Medicine, University of California, San Diego (L.J.R.); the Division of Pulmonary and Critical Care Medicine, Cedars-Sinai Medical Center, Los Angeles (V.T.); Minsk Regional Clinical Hospital, Minsk, Belarus (I.A.); the Department of Pulmonary Circulation, Shanghai Pulmonary Hospital, Shanghai (J.L.), and the Department of Rheumatology, Peking Union Medical College Hospital, Beijing (X.Z.) - both in China; Federal Almazov North-West Medical Research Center, St. Petersburg, Russia (O.M.); and the Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan Health System, Ann Arbor (V.V.M.).

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http://dx.doi.org/10.1056/NEJMoa1503184DOI Listing
December 2015

5-HT2B receptor antagonists inhibit fibrosis and protect from RV heart failure.

Biomed Res Int 2015 1;2015:438403. Epub 2015 Feb 1.

Universities of Giessen and Marburg Lung Centre (UGMLC), Aulweg 130, 35392 Giessen, Germany ; German Center for Lung Research (DZL), 35392 Giessen, Germany.

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http://dx.doi.org/10.1155/2015/438403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312574PMC
October 2015

Chymase: a multifunctional player in pulmonary hypertension associated with lung fibrosis.

Eur Respir J 2015 Oct 25;46(4):1084-94. Epub 2015 Jun 25.

Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research, Giessen, Germany Both authors contributed equally

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http://dx.doi.org/10.1183/09031936.00018215DOI Listing
October 2015

Bosentan added to sildenafil therapy in patients with pulmonary arterial hypertension.

Eur Respir J 2015 Aug 25;46(2):405-13. Epub 2015 Jun 25.

Department of Respiratory Medicine, Hannover Medical School and German Center of Lung Research (DZL), Hannover, Germany.

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http://dx.doi.org/10.1183/13993003.02044-2014DOI Listing
August 2015

Initial Use of Ambrisentan plus Tadalafil in Pulmonary Arterial Hypertension.

N Engl J Med 2015 Aug;373(9):834-44

From the Department of Experimental, Diagnostic, and Specialty Medicine, University of Bologna, Bologna, Italy (N.G.); Hospital Clínic-Institut d'Investigacions Biomèdiques August Pi i Sunyer and University of Barcelona, Barcelona, and Biomedical Research Networking Center on Respiratory Diseases, Madrid (J.A.B.); Baylor College of Medicine, Houston (A.E.F.); Universities of Giessen and Marburg Lung Center, Giessen (H.-A.G.), Hanover Medical School and German Center of Lung Research, Hanover (M.M.H.), and Thoraxklinik at University Hospital Heidelberg, Heidelberg (E.G.) - all in Germany; University of Michigan Health System, Ann Arbor (V.V.M.); Regional Heart and Lung Centre, Glasgow (A.J.P.), and GlaxoSmithKline, Uxbridge (J.H.N.H., J.L.) - both in the United Kingdom; Université Paris-Sud, Faculté de Médecine, and Assistance Publique-Hôpitaux de Paris, Centre de Référence de l'Hypertension Pulmonaire Sévère, Département Hospitalo-Universitaire Thorax Innovation, Service de Pneumologie, Hôpital de Bicêtre, Le Kremlin Bicêtre, INSERM Unité Mixté de Recherche S 999, Laboratoire d'Excellence en Recherche sur le Médicament et l'Innovation Thérapeutique, Centre Chirurgical Marie Lannelongue, Le Plessis-Robinson - all in France (G.S.); Universitaires de Bruxelles-Hôpital Erasme, Brussels (J.-L.V.); Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance (R.J.O.), Gilead Sciences, Foster City (C.B., H.G., K.L.M.), and University of California at San Diego, La Jolla (L.J.R.) - all in California; VU University Medical Center, Amsterdam (A.V.-N.); and the University of Rochester, Rochester, NY (R.J.W.).

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http://dx.doi.org/10.1056/NEJMoa1413687DOI Listing
August 2015

Riociguat for the treatment of pulmonary arterial hypertension: a long-term extension study (PATENT-2).

Eur Respir J 2015 May 22;45(5):1303-13. Epub 2015 Jan 22.

University of Giessen and Marburg Lung Center (UGMLC), Giessen, Germany Member of the German Center of Lung Research (DZL) Dept of Medicine, Imperial College London, London, UK.

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http://dx.doi.org/10.1183/09031936.00090614DOI Listing
May 2015

Use of clinically relevant responder threshold criteria to evaluate the response to treatment in the phase III PATENT-1 study.

J Heart Lung Transplant 2015 Mar 12;34(3):338-47. Epub 2014 Dec 12.

University of Giessen and Marburg Lung Center, Giessen, Germany, German Center of Lung Research, and Department of Medicine, Imperial College London, London, United Kingdom.

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http://dx.doi.org/10.1016/j.healun.2014.12.001DOI Listing
March 2015

Use of responder threshold criteria to evaluate the response to treatment in the phase III CHEST-1 study.

J Heart Lung Transplant 2015 Mar 16;34(3):348-55. Epub 2015 Feb 16.

Clinic for Respiratory Medicine, Hannover Medical School, Hannover, Germany, and Member of the German Centre of Lung Research (DZL).

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http://dx.doi.org/10.1016/j.healun.2015.02.003DOI Listing
March 2015

Pathophysiology and treatment of high-altitude pulmonary vascular disease.

Circulation 2015 Feb;131(6):582-90

From Experimental Medicine, Imperial College London, Hammersmith Hospital, United Kingdom (M.R.W., H.-A.G., L.Z.); Excellence Cluster Cardio-Pulmonary System, Universities of Giessen, Germany (M.R.W., H.-A.G., N.W., L.Z.); University of Giessen Marburg Lung Center, Justus-Liebig-University, Germany (M.R.W., H.-A.G., N.W., L.Z.); Kerckhoff Clinic, Bad Nauheim, Germany (H.-A.G.); Institute of Molecular Biology and Medicine, Bishkek, Kyrgyzstan (A.A.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.114.006977DOI Listing
February 2015

Poor sleep quality is associated with exercise limitation in precapillary pulmonary hypertension.

BMC Pulm Med 2015 Feb 13;15:11. Epub 2015 Feb 13.

Department of Sleep Medicine, University of Giessen Lung Center, Klinikstr. 33, 35392, Giessen, Germany.

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http://dx.doi.org/10.1186/s12890-015-0005-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342878PMC
February 2015

Effect of macitentan on hospitalizations: results from the SERAPHIN trial.

JACC Heart Fail 2015 Jan 11;3(1):1-8. Epub 2014 Nov 11.

Department of Experimental, Diagnostic and Specialty Medicine-DIMES, Bologna University Hospital, Bologna, Italy.

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http://dx.doi.org/10.1016/j.jchf.2014.07.013DOI Listing
January 2015