Publications by authors named "Hossein Rahmani"

37 Publications

Modification of chitosan using amino acids for wound healing purposes: A review.

Carbohydr Polym 2021 Apr 22;258:117675. Epub 2021 Jan 22.

Department of Chemical Technologies, Iranian Research Organization for Science and Technology (IROST), Tehran, Iran.

Chitosan, a well-known biopolymer due to its unique properties, has received considerable attention as a result of the amine group activity that locates on the backbone of chitosan. To improve the mechanical and antibacterial characteristics of chitosan, various modifications have been used. Amino acids, the monomeric units of proteins, among all other compounds have been chosen to discuss as promising materials for wound healing in combination with chitosan. This review aims to provide an up-to-date overview of the methods used for modification of chitosan and the potential biomedical application, in particular wound healing, reported in the literature during the last five years.
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http://dx.doi.org/10.1016/j.carbpol.2021.117675DOI Listing
April 2021

Tarvajeh: Word Association Norms for Persian Words.

J Psycholinguist Res 2021 Jan 4. Epub 2021 Jan 4.

School of Computer Engineering, Iran University of Science and Technology, Tehran, Iran.

In recent years, word associations have played a key role in cognitive research. The goal of this study is to propose a new system called Tarvajeh to construct and analyze the association norms found in the Persian language. In this paper, we present Tarvajeh, a data set for Persian words in a continuous word association task. For data collection, cue words have been categorized into groups and then, 30 of them were presented to each participant in two phases. Afterward, the participants were asked to write the first three words that are related to the initial cue words. After data collection, Tarvajeh included 240 frequent Persian cues and more than 20,000 different responses. Furthermore, we also propose a method that allows participants to compare their responses as well as their subconscious mind with those of their peers using a unique graph that is tailored to their responses and is displayed to them. Finally, we compared our data with those of associated words in other languages. The comparison reveals that, for some cues, most associated words are the same, while for others, the most frequent responses are unique within each data set. In addition, some gender-related differences were observed with male participants spending more time on their responses than female participants.
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http://dx.doi.org/10.1007/s10936-020-09751-2DOI Listing
January 2021

Interplay of isoform 1N4R tau protein and amyloid-β peptide fragment 25-35 in reducing and non-reducing conditions.

J Biochem 2021 Feb;169(1):119-134

Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Jalal AleAhmad Highway, P.O.Box: 14115-111, Iran.

Amyloid-β (Aβ) peptide and tau protein are two hallmark proteins in Alzheimer's disease (AD); however, the parameters, which mediate the abnormal aggregation of Aβ and tau, have not been fully discovered. Here, we have provided an optimum method to purify tau protein isoform 1N4R by using nickel-nitrilotriacetic acid agarose chromatography under denaturing condition. The biochemical and biophysical properties of the purified protein were further characterized using in vitro tau filament assembly, tubulin polymerization assay, circular dichroism (CD) spectroscopy and atomic force microscopy. Afterwards, we investigated the effect of tau protein on aggregation of Aβ (25-35) peptide using microscopic imaging and cell viability assay. Incubation of tau at physiologic and supra-physiologic concentrations with Aβ25-35 for 40 days under reducing and non-reducing conditions revealed formation of two types of aggregates with distinct morphologies and dimensions. In non-reducing condition, the co-incubated sample showed granular aggregates, while in reducing condition, they formed annular protofibrils. Results from cell viability assay revealed the increased cell viability for the co-incubated sample. Therefore, the disassembling action shown by tau protein on Aβ25-35 suggests the possibility that tau may have a protective role in preventing Aβ peptide from acquiring the cytotoxic, aggregated form against oxidative stress damages.
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http://dx.doi.org/10.1093/jb/mvaa101DOI Listing
February 2021

ADDI: Recommending alternatives for drug-drug interactions with negative health effects.

Comput Biol Med 2020 10 19;125:103969. Epub 2020 Aug 19.

Quadram Institute Bioscience, Norwich Research Park, Norwich, Norfolk, NR4 7UQ, UK; Earlham Institute Norwich Research Park, Norwich, NR4 7UZ, UK.

Investigating the interactions among various drugs is an indispensable issue in the field of computational biology. Scientific literature represents a rich source for the retrieval of knowledge about the interactions between drugs. Predicting drug-drug interaction (DDI) types will help biologists to evade hazardous drug interactions and support them in discovering potential alternatives that increase therapeutic efficacy and reduce toxicity. In this paper, we propose a general-purpose method called ADDI (standing for Alternative Drug-Drug Interaction) that applies deep learning on PubMed abstracts to predict interaction types among drugs. As an application, ADDI recommends alternatives for drug-drug interactions (DDIs) which have Negative Health Effects Types (NHETs). ADDI clearly outperforms state-of-the-art methods, on average by 13%, with respect to accuracy by using only the textual content of the online PubMed papers. Additionally, manual evaluation of ADDI indicates high precision in recommending alternatives for DDIs with NHETs.
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http://dx.doi.org/10.1016/j.compbiomed.2020.103969DOI Listing
October 2020

Enhanced sensitivity of VEGF detection using catalase-mediated chemiluminescence immunoassay based on CdTe QD/HO system.

J Nanobiotechnology 2020 Jun 17;18(1):93. Epub 2020 Jun 17.

Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, 14115-154, Iran.

Background: Since vascular endothelial growth factor (VEGF) is a significant regulator of cancer angiogenesis, it is essential to develop a technology for its sensitive detection. Herein, we sensitized a chemiluminescence (CL) immunoassay through the combination of HO-sensitive TGA-CdTe quantum dot (QD) as signal transduction, dextran as a cross-linker to prepare enzyme-labeled antigen and the ultrahigh bioactivity of catalase (CAT) as reporter enzyme.

Results: Under the optimized experimental conditions, the chemiluminescence enzyme-linked immunosorbent assay (CL-ELISA) method can detect VEGF in the excellent linear range of 2-35,000 pg mL, with a detection limit (S/N = 3) of 0.5 pg mL which was approximately ten times lower than the commercial colorimetric immunoassay. This proposed method has been successfully applied to the clinical determination of VEGF in the human serum samples, and the results illustrated an excellent correlation with the conventional ELISA method (R = 0.997). The suitable recovery rate of the method in the serum ranged from 97 to 107%, with a relative standard deviation of 1.2% to 13.4%.

Conclusions: The novel immunoassay proposes a highly sensitive, specific, and stable method for very low levels detection of VEGF that can be used in the primary diagnosis of tumors. With the well-designed sensing platform, this approach has a broad potential to be applied for quantitative analysis of numerous disease-related protein biomarkers for which antibodies are available.
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http://dx.doi.org/10.1186/s12951-020-00648-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302009PMC
June 2020

EMDIP: An Entropy Measure to Discover Important Proteins in PPI networks.

Comput Biol Med 2020 05 4;120:103740. Epub 2020 Apr 4.

Centre for Molecular Informatics, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, United Kingdom.

Discovering important proteins in Protein-Protein Interaction (PPI) networks has attracted a lot of attention in recent years. Most of the previous work applies different network centrality measures such as Closeness, Betweenness, PageRank and many others to discover the most influential proteins in PPI networks. Although entropy is a well-known graph-based method in computer science, according to our knowledge, it is not used in the biology domain for this purpose. In this paper, first, we annotate the human PPI network with available annotation data. Second, we introduce a new concept called annotation-context that describes each protein according to annotation data of its neighbors. Third, we apply an entropy measure to discover proteins with varied annotation-context. Empirical results indicate that our proposed method succeeded in (1) differentiating essential and non-essential proteins in PPI networks with annotation data; (2) outperforming centrality measures in the task of discovering essential nodes; (3) predicting new annotated proteins based on existing annotation data.
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http://dx.doi.org/10.1016/j.compbiomed.2020.103740DOI Listing
May 2020

Preparation of chitosan-based composites with urethane cross linkage and evaluation of their properties for using as wound healing dressing.

Carbohydr Polym 2020 Feb 16;230:115606. Epub 2019 Nov 16.

Department of Chemical Technologies, Iranian Research Organization for Science and Technology (IROST), Tehran, Iran.

In this research, biocomposite films containing chitosan (CS), polyvinyl alcohol (PVA) and polyvinyl pyrrolidone (PVP), with different ratios, have been provided. The effects of adding hexamethylene 1, 6-di(aminocarboxysulfonate) (HMDACS) as cross-linking agent and the formation of urethane linkage on mechanical properties such as tensile strength, elongation and dynamic-mechanical properties such as storage modulus and tan δ were studied. Also, the antibacterial properties of the composites were investigated by viable bacterial cell counting and compared in reducing the bacterial growth. The final results showed the composite containing CS (50 wt%), PVA (30 wt%), PVP (20 wt%) and HMDACS (2 wt%) had the highest mechanical properties. Scanning electron microscopy (SEM) micrographs confirmed uniform distribution of components in the polymer matrix. In general, low contact angle values revealed the hydrophilicity of the prepared films. It was found that the composites made by combining CS, PVA and PVP at concentration of 50, 25, 25 wt% (A3) and 60, 20, 20 wt% (B4), cross-linked with 2 wt% HMDACS, had the best antibacterial activity against Escherichia coli and Staphylococcus aureus, hence they can be used as promising materials for the preparation of wound dressings.
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http://dx.doi.org/10.1016/j.carbpol.2019.115606DOI Listing
February 2020

Bioluminescence Detection of Superoxide Anion Using Aequorin.

Anal Chem 2019 10 2;91(20):12768-12774. Epub 2019 Oct 2.

Department of Biochemistry, Faculty of Biological Sciences , Tarbiat Modares University , Tehran 14115-154 , Iran.

Although the superoxide anion (O) is generated during normal cellular respiration and has fundamental roles in a wide range of cellular processes, such as cell proliferation, migration, apoptosis, and homeostasis, its dysregulation is associated with a variety of diseases. Regarding these prominent roles in biological systems, the development of accurate methods for quantification of superoxide anion has attracted tremendous research attention. Here, we evaluated aequorin, a calcium-dependent photoprotein, as a potential bioluminescent reporter protein of superoxide anion. The mechanism is based on the measurement of aequorin bioluminescence, where the lower the concentration of coelenterazine under the oxidation of superoxide anion, the lower the amount aequorin regeneration, leading to a decrease in bioluminescence. The bioluminescence intensity of aequorin was proportional to the concentration of superoxide anion in the range from 4 to 40 000 pM with a detection limit (S/N = 3) of 1.2 pM, which was 5000-fold lower than those of the chemiluminescence methods. The proposed method exhibited high sensitivity and has been successfully applied to the determination of superoxide anion in the plant cell samples. The results could suggest a photoprotein-based bioluminescence system as a highly sensitive, specific, and simple bioluminescent probe for detection of superoxide anion.
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http://dx.doi.org/10.1021/acs.analchem.9b02293DOI Listing
October 2019

Learning Latent Global Network for Skeleton-based Action Prediction.

IEEE Trans Image Process 2019 Sep 2. Epub 2019 Sep 2.

Human actions represented with 3D skeleton sequences are robust to clustered backgrounds and illumination changes. In this paper, we investigate skeleton-based action prediction, which aims to recognize an action from a partial skeleton sequence that contains incomplete action information. We propose a new Latent Global Network based on adversarial learning for action prediction. We demonstrate that the proposed network provides latent long-term global information that is complementary to the local action information of the partial sequences and helps improve action prediction. We show that action prediction can be improved by combining the latent global information with the local action information. We test the proposed method on three challenging skeleton datasets and report state-of-the-art performance.
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http://dx.doi.org/10.1109/TIP.2019.2937757DOI Listing
September 2019

Impact of Implementing the Critical Care Pain Observation Tool on Nurses' Performance in Assessing and Managing Pain in the Critically Ill Patients.

Indian J Crit Care Med 2019 Apr;23(4):165-169

Nursing Research Center, Golestan University of Medical Sciences, Gorgan, Iran.

Background And Aims: Pain management is one of the most important responsibilities of nurses in an intensive care unit (ICU). It is difficult to perform pain assessment appropriately in patients who are unable to report their pain. This study is aimed to determine the impact of implementing the critical care pain observation tool (CPOT) on the amount and frequency of analgesics' administration in ICUs.

Materials And Methods: This interventional study was conducted in 2014. Sixty nurses and 240 patients were studied. This study was carried out in three phases: first the data about amount and frequency of analgesic administration were extracted from patients' medical files. Then the CPOT was implemented into the nursing assessment process and finally, nurses' performance regarding the amount and frequency of analgesic administration was recorded. This data obtained before and after intervention were analyzed using chi-square and independent t-test values less than 0.05 were considered significant.

Results: In this interventional study, we found that there was no difference in the demography and cause of ICU admission before and after implementation of CPOT (age = 0.937, gender = 0.996, and the cause of admission = 0.996). We found that after implementing the CPOT into the nursing assessment process, the amount of analgesics administered (7.95 ± 8.77 mg vs. 11.01 ± 11.04 mg, = 0.018) and the frequency of administration (2.91 ± 1.38 vs. 4.16 ± 0.99, <0.001) increased significantly. Moreover, there was a significant increase in the frequency of pain assessment per patient per day in nursing practice after implementation of CPOT as compared to the practice before (7.2 ± 2.48 vs. 1.03 ± 1.63, <0.001). The mean pain scores before and after the intervention (5.5 ± 1.08 vs.2.2 ± 0.48) were also significantly different.

Conclusion: Applying CPOT, as an objective mean of pain assessment, was effective in improving the performance of ICU nurses in assessment and management of patients' pain. It increased the amount and frequency of analgesic administration. We can recommend that COPT is a useful tool for assessment and management of pain in ICU patients and should be implemented in all ICUs.

How To Cite This Article: Modanloo M, Mohsenpour A, Impact of Implementing the Critical Care Pain Observation Tool on Nurses' Performance in Assessing and Managing Pain in the Critically Ill Patients. Indian J Crit Care Med 2019;23(4):165-169.
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http://dx.doi.org/10.5005/jp-journals-10071-23146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521825PMC
April 2019

Aequorin as a sensitive and selective reporter for detection of dopamine: A photoprotein inhibition assay approach.

Int J Biol Macromol 2019 Feb 2;122:677-683. Epub 2018 Nov 2.

Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran 14115-154, Iran. Electronic address:

Dopamine is a metabolite that plays a key role in the human body and in biomedical and diagnostic applications. Thus, the concentration of this analyte has been considered in various diseases in therapeutic drug monitoring (TDM). In the present study, for the first time, a photoprotein inhibition assay strategy was developed by utilizing aequorin for the direct detection of dopamine as a receptor and reporter simultaneously. The results showed that bioluminescence emission of aequorin was effectively quenched by increasing concentration of dopamine at the range of 1 nM to 100 μM with a detection limit of 53 nM. The viability of this method for the monitoring of dopamine in spiked biological fluids was also established and it was successfully applied for the direct determination of dopamine in a blood serum and urine without preliminary treatment with satisfactory quantitative recovery 90-95% and 82-93%, respectively. The structural investigation using circular dichroism, fluorescence spectroscopy, and docking simulation indicated that, changes in the microenvironment of aromatic residues were significant, while minor conformational alterations of the protein were observed. It seems dopamine inhibits bioluminescence activity with specific binding to the residues involved in the light production.
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http://dx.doi.org/10.1016/j.ijbiomac.2018.10.221DOI Listing
February 2019

The systemic nature of mustard lung: Comparison with COPD patients.

Interdiscip Toxicol 2017 Nov 14;10(3):114-127. Epub 2018 Feb 14.

Chemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.

Sulphur mustard (SM) is a powerful blister-causing alkylating chemical warfare agent used by Iraqi forces against Iran. One of the known complications of mustard gas inhalation is mustard lung which is discussed as a phenotype of chronic obstructive pulmonary disease (COPD). In this complication, there are clinical symptoms close to COPD with common etiologies, such as in smokers. Based on information gradually obtained by conducting the studies on mustard lung patients, systemic symptoms along with pulmonary disorders have attracted the attention of researchers. Changes in serum levels of inflammatory markers, such as C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α), nuclear factor κB (NF-κB), matrix metalloproteinases (MMPs), interleukin (IL), chemokines, selectins, immunoglobulins, and signs of imbalance in oxidant-antioxidant system at serum level, present the systemic changes in these patients. In addition to these, reports of extra-pulmonary complications, such as osteoporosis and cardiovascular disease are also presented. In this study, the chance of developing the systemic nature of this lung disease have been followed on using the comparative study of changes in the mentioned markers in mustard lung and COPD patients at stable phases and the mechanisms of pathogenesis and phenomena, such as airway remodeling in these patients.
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http://dx.doi.org/10.1515/intox-2017-0018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107649PMC
November 2017

Nursing managers attitude toward spirituality and spiritual care in Khorasan Razavi Province hospitals in 2016.

Electron Physician 2018 Mar 25;10(3):6571-6576. Epub 2018 Mar 25.

M.Sc. of Intensive Care Nursing, Department of Operating Room, Faculty Member of Neyshabur University of Medical Sciences, Neyshabur, Iran.

Background And Aim: Spiritual care is an important part of nursing practice that seems to provide comprehensive care to patients. Nursing manager's attention to the spiritual dimension is one of the most important aspects affecting human health. Therefore, the aim of this study was to determine nursing managers' attitude to spirituality and spiritual care in hospitals in Khorasan Razavi Province in 2016.

Methods: In this cross-sectional study, 110 management nurses (8 matrons, 37 supervisors and 65 head nurses) of hospitals in Khorasan Razavi Province (2016) were recruited for the study. Data were collected using a Spirituality & Spiritual Care Rating Scale (SSCRS) questionnaire in two parts, demographic information and questions related to the research objectives. Data were collected and analyzed using SPSS 16 software and doing descriptive (frequency, mean, standard deviation) and inferential statistics (independent-samples t-test, ANOVA) and considering levels of significance (p<0.05).

Results: The results showed mean and standard deviation in management nursing attitude to spirituality (4.01±0.35) and spiritual care (4.03±0.78). The result showed significant differences between the attitude to spirituality and spiritual care and gender, age and work experience in nursing management (p<0.05).

Conclusions: Management nursing has high level attitude to spirituality and spiritual care. Therefore, providing the perfect platform to provide this care, and for nurses to implement it in hospitals is recommended.
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http://dx.doi.org/10.19082/6571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5942580PMC
March 2018

Risks of on-pump coronary artery bypass grafting surgery in patients with chronic obstructive pulmonary disease due to sulfur mustard.

Postepy Dermatol Alergol 2017 Oct 31;34(5):429-432. Epub 2017 Oct 31.

Department of Cardiac Surgery, Atherosclerosis Research Center and Imam Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Sulfur mustard (SM) is a toxic chemical agent that belongs to a class of vesicant compounds. In the 1980s it was used by the Iraqi army against Iranian forces. Sulfur mustard severely irritates the skin, eyes and lungs. The highest side effects seen in patients affected by this gas are pulmonary complications including different types of lung diseases such as bronchiolitis. It has also led to a certain type of chronic obstructive pulmonary disease called mustard lung. Similar extra-pulmonary, molecular and hormonal effects can be observed in these patients and patients with chronic obstructive pulmonary disease. Here cardiovascular complications may be one of the most dangerous visible effects. And atherosclerosis is probable following the direct effects or consequential long-term effects of SM. The development of atherosclerosis in these patients is associated with an increased risk of cardiovascular and coronary artery disease. Coronary artery bypass grafting surgery is the treatment of coronary artery disease. Doing this surgery by bypass pump has its own morbidity and due to local and systemic inflammation changes in patients with SM pulmonary disorders it may have more side effects. Therefore, detailed knowledge of inflammatory diseases as well as the serum level or even the local lung fluid of the inflammatory factors in these patients before surgery are needed so that it would be possible to reduce the rate of morbidity and mortality by normalizing the inflammatory conditions of the patients before cardiac surgery.
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http://dx.doi.org/10.5114/ada.2017.71107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831276PMC
October 2017

Relationship of serum levels of interleukin 6, interleukin 8, and C-reactive protein with forced expiratory volume in first second in patients with mustard lung and chronic obstructive pulmonary diseases: systematic review and meta-analysis.

Postepy Dermatol Alergol 2017 Jun 29;34(3):192-198. Epub 2017 May 29.

Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.

Introduction: The chronic systemic inflammation is a result of releasing inflammatory cytokines from the cells relating to the body immunity system and chronic activation of the innate immunity system.

Aim: To evaluate the relationship among serum levels of interleukin 6 (IL-6), interleukin 8 (IL-8), C-reactive protein (CRP) with forced expiratory volume in 1 s (FEV) in patients with mustard lung (ML) and chronic obstructive pulmonary diseases (COPD).

Material And Methods: A published literature search was performed through SID, web of science, ISI, Science Direct, Scopus, Medline, and PubMed databases for articles published in English. The correlation coefficient () and 95% confidence intervals (95% CIs) were calculated using random or fixed effects models. Heterogeneity was assessed using χ and statistics.

Results: In total, 4 published studies were included in the final analysis. Using the random-effect model, meta-analysis showed that the was -0.052 (95% CI: -0.14-0.049, = 0.28) at serum level of IL-8, serum levels of CRP and FEV in these results were = -0.13, = 0.012, serum levels of tumor necrosis factor (TNF) and FEV levels were = -0.39, = 0.03 in the conducted studies on mustard lung patients. The IL-6 serum level was explored in COPD patients. The results of the given studies in these patients are = -0.006, 95% CI: -0.37-0.15, and = 0.44.

Conclusions: In this meta-analysis, there was evidence that serum levels of CRP and TNF have been significantly increased in chronic obstructive pulmonary diseases compared to the healthy control group, which signifies the presence of systemic inflammation in ML and COPD patients.
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http://dx.doi.org/10.5114/ada.2017.67841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471374PMC
June 2017

Learning a Deep Model for Human Action Recognition from Novel Viewpoints.

IEEE Trans Pattern Anal Mach Intell 2018 03 6;40(3):667-681. Epub 2017 Apr 6.

Recognizing human actions from unknown and unseen (novel) views is a challenging problem. We propose a Robust Non-Linear Knowledge Transfer Model (R-NKTM) for human action recognition from novel views. The proposed R-NKTM is a deep fully-connected neural network that transfers knowledge of human actions from any unknown view to a shared high-level virtual view by finding a set of non-linear transformations that connects the views. The R-NKTM is learned from 2D projections of dense trajectories of synthetic 3D human models fitted to real motion capture data and generalizes to real videos of human actions. The strength of our technique is that we learn a single R-NKTM for all actions and all viewpoints for knowledge transfer of any real human action video without the need for re-training or fine-tuning the model. Thus, R-NKTM can efficiently scale to incorporate new action classes. R-NKTM is learned with dummy labels and does not require knowledge of the camera viewpoint at any stage. Experiments on three benchmark cross-view human action datasets show that our method outperforms existing state-of-the-art.
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http://dx.doi.org/10.1109/TPAMI.2017.2691768DOI Listing
March 2018

Ca2+ Binding and Conformational Switch of the Photoprotein Mnemiopsin.

Protein Pept Lett 2017 Aug;24(6):476-482

Department of Biophysics, Faculty of Biological Sciences, Tarbiat modares University, Tehran, Iran.

Background: Bioluminescence in Ca2+-binding photoproteins is an intramolecular reaction triggered by the addition of Ca2+. A comparative study has been done on Ca2+-depleted and Ca2+-loaded apo-mnemiopsin to understand the structural transition of the photoprotein by Ca2+ binding. Ca2+ is removed by TCA (trichloroacetic acid) precipitation to obtain Ca2+-depleted apomnemiopsin.

Method: UV-visible, CD and fluorescence spectroscopic studies demonstrate that the addition of Ca2+ is brought about by the overall structure of apo-mnemiopsin becomes more open in a concentration- dependent manner without significantly influencing the secondary structure and indicate that the Ca2+-depleted form of apo-mnemiopsin, in contrast to most other EF-hand calcium binding proteins, adopt a closed conformation when compared to the Ca2+-loaded form. On the other hand, dynamic quenching and limited proteolysis analysis revealed that Ca2+-loaded apo-mnemiopsin became much more flexible than Ca2+ free apo-mnemiopsin.

Results: It seems that increased flexibility of the protein, which occurs due to calcium binding, is a critical factor in oxidative decarboxylation reaction on coelenterazine and consequently light emission.
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http://dx.doi.org/10.2174/0929866524666170310110318DOI Listing
August 2017

Allosteric properties of Geobacillus maltogenic amylase.

Enzyme Microb Technol 2017 Jan 20;96:36-41. Epub 2016 Sep 20.

Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.

Maltogenic amylases (MAases, EC 3.2.1.133) have been gotten much attention due to their various applications in industry and commercial processes. MAases belong to subfamily 20 of glycoside hydrolase family 13 (NPase or CDases subfamily) and they have important differences with other members of the family. This enzyme consists of two subunits which form two active sites in the dimer form by binding of the central domain of each subunit to the N domain of the next one (domain-swapping dimeric structure). Allosterism is a possible way of regulating enzymatic activity and no evidence has been found regarding to the cooperativity and correlation between MAases subunits, therefore in this study the allosteric behavior of MAases from a native strain (Geobacillus sp. Gh6) was investigated. Unlike other members of α-amylase family, MAases showed positive cooperativity between their subunits and the enzyme exhibited sigmoidal nature towards all three cyclodextrin (CD) substrates with a Hill constant (nH) value equal to 2, 1.6 and 1.1 for α-CD, β-CD and γ-CD, respectively. On further analysis, the effect of glucose and maltose as MAases allosteric effectors in the presence of β-CD substrate showed that these two effectors had a biphasic effect; while they stimulated the enzyme activity at low concentrations (with a decrease in Hill constant), these metabolites acted as allosteric inhibitors at higher concentrations. Due to the key role of MAases in carbohydrate metabolization, an efficient regulating system for this enzyme is required. In this experiment, for the first time the allosteric properties of MAases were observed and investigated.
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http://dx.doi.org/10.1016/j.enzmictec.2016.09.011DOI Listing
January 2017

Respiratory Complications Due to Sulfur Mustard Exposure.

Int J Curr Res Acad Rev 2016 Jun;4(6):143-149

Hyperlipidemia Research Center, Department of Laboratory Sciences, School of Paramedical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Sulfur mustard (SM) or bis (2-chloroethyl) sulfide is a vesicant and alkylating chemical weapon. SM was used in the 1980s against Iran by Iraqi forces. After exposure to SM in initial acute phase the greatest damage is incurred by the eyes, skin and lungs and the highest damage is caused to the lungs. This injury not only in the acute phase but also in the long-term has the highest prevalence among these patients. Clinical symptoms of people after exposure to SM start with irritation of the nose and sinuses in the mild doses to the runny nose and pain at higher doses and even irritation of the airways and bronchial engagement in very high doses. Respiratory complications in patients exposed to SM have been associated with long-term symptoms and these symptoms add to the intensity of the complication. Bloody sputum, feeling of tightness in the chest and shortness of breath over nights are among common symptoms; also the main respiratory symptoms including generalized wheezing, rale (crackle), decreased breath sounds and cyanosis and Apparently FEV1 is reduced by 50 mL/year. In these patients there are changes in blood cells especially in white blood cells and neutrophils and systemic inflammation and systemic changes with other comorbidities are observed. Although SM pulmonary patients' treatment is based on bronchodilators and long-acting-β2 agonists, paying attention to the comorbidities with prior systemic changes in these patients is a reason for the need to change treatment strategies of these patients with systemic and extra-pulmonary therapy.
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June 2016

Applications of cardiotoxicity in breast cancer: a meta-analysis.

Panminerva Med 2017 Mar 17;59(1):90-96. Epub 2016 Jun 17.

Department of Anesthesiology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Introduction: Breast cancer is the most common type of cancer in women. Many antineoplastic agents used to treat breast cancer have potentially cardiotoxic effects and may lead to chemotherapy induced cardiomyopathy and heart failure. We conducted a meta-analysis to clarify the applications of cardiotoxicity in breast cancer.

Evidence Acquisition: A published literature search was performed through PubMed, Cochrane Library, Medline, and Science Citation Index Expanded databases for articles published in English. Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated using random or fixed effects models. Heterogeneity was assessed using χ2 and I2 statistics. We performed a formal meta-analysis using summary measures from these studies.

Evidence Synthesis: In total, 9 published studies were included in the final analysis. The combined analysis revealed that there was non-significant regardless of the statistical ejection fraction (OR=0.98, 95% CI: 0.63-1.54, P=0.96) and left ventricular ejection fraction (OR=1.04; 95% CI: 0.69-1.56, P=0.85) decline method used. Additionally, the pooled OR was 0.99 (95% CI: 0.79-1.28) for the trastuzumab plus lapatinib combination, and 1.00 (95% CI: 0.88-1.13) for the trastuzumab plus pertuzumab combination.

Conclusions: In this meta-analysis, there was evidence indicated that there was not a significant decrease on LVEF and EF in patients who received trastuzumab plus lapatinib and trastuzumab plus pertuzumab combination. Our study suggests that the combination of two anti-HER2 agents does not significantly increase the risk for adverse compared with anti-HER2 monotherapy in patients with adequate cardiac function prior to start of therapy.
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http://dx.doi.org/10.23736/S0031-0808.16.03201-8DOI Listing
March 2017

Histogram of Oriented Principal Components for Cross-View Action Recognition.

IEEE Trans Pattern Anal Mach Intell 2016 12 25;38(12):2430-2443. Epub 2016 Feb 25.

Existing techniques for 3D action recognition are sensitive to viewpoint variations because they extract features from depth images which are viewpoint dependent. In contrast, we directly process pointclouds for cross-view action recognition from unknown and unseen views. We propose the histogram of oriented principal components (HOPC) descriptor that is robust to noise, viewpoint, scale and action speed variations. At a 3D point, HOPC is computed by projecting the three scaled eigenvectors of the pointcloud within its local spatio-temporal support volume onto the vertices of a regular dodecahedron. HOPC is also used for the detection of spatio-temporal keypoints (STK) in 3D pointcloud sequences so that view-invariant STK descriptors (or Local HOPC descriptors) at these key locations only are used for action recognition. We also propose a global descriptor computed from the normalized spatio-temporal distribution of STKs in 4-D, which we refer to as STK-D. We have evaluated the performance of our proposed descriptors against nine existing techniques on two cross-view and three single-view human action recognition datasets. The experimental results show that our techniques provide significant improvement over state-of-the-art methods.
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http://dx.doi.org/10.1109/TPAMI.2016.2533389DOI Listing
December 2016

ARWAR: A network approach for predicting Adverse Drug Reactions.

Comput Biol Med 2016 Jan 23;68:101-8. Epub 2015 Nov 23.

Centre for Molecular Informatics, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom.

Predicting novel drug side-effects, or Adverse Drug Reactions (ADRs), plays an important role in the drug discovery process. Existing methods consider mainly the chemical and biological characteristics of each drug individually, thereby neglecting information hidden in the relationships among drugs. Complementary to the existing individual methods, in this paper, we propose a novel network approach for ADR prediction that is called Augmented Random-WAlk with Restarts (ARWAR). ARWAR, first, applies an existing method to build a network of highly related drugs. Then, it augments the original drug network by adding new nodes and new edges to the network and finally, it applies Random Walks with Restarts to predict novel ADRs. Empirical results show that the ARWAR method presented here outperforms the existing network approach by 20% with respect to average Fmeasure. Furthermore, ARWAR is capable of generating novel hypotheses about drugs with respect to novel and biologically meaningful ADR.
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http://dx.doi.org/10.1016/j.compbiomed.2015.11.005DOI Listing
January 2016

Alternative Methods to Treat Nausea and Vomiting from Cancer Chemotherapy.

Chemother Res Pract 2015 8;2015:818759. Epub 2015 Nov 8.

Department of Toxicology, Islamic Azad University, Shahreza Branch and Medical Research Center, Jundishapur Health Development Co., Tehran, Iran.

Chemotherapy Induced Nausea and Vomiting (CINV) is among the most intensive side effects and critical concerns for patients with cancer. Most of these patients experience nausea and vomiting after chemotherapy. Sometimes, this is so annoying that it may prevent them from continuing the therapy. With the recent advances, a variety of therapeutic methods are innovated and applied to control CINV. Among them, the main methods include medicinal therapy, relaxation, and herbal therapy. Yet, using dexamethasone together with massage therapy and ginger is identified as the most effective method.
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http://dx.doi.org/10.1155/2015/818759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655029PMC
December 2015

A cross-sectional study of prevalence and risk factors for childhood asthma in Ahvaz city, Iran.

Postepy Dermatol Alergol 2015 Aug 12;32(4):268-73. Epub 2015 Aug 12.

Departments of Toxicology, Shahreza Branch, Islamic Azad University, Shahreza, Iran ; Medical Research Center, Jundishapur Health Development Co, Tehran, Iran.

Introduction: Childhood asthma is the main public health problem in world, and dramatically has increased in developed as well as developing countries.

Aim: To assess prevalence and risk factors for asthma based on ISAAC questionnaire.

Material And Methods: It was a cross-sectional school population-based study which was carried out on 1803 school children aged 6-7 and 13-14 in Ahvaz city, Khuzestan, south west of Iran, in 2011. The International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire was used as a tool to identify prevalence of asthma. Chi-square (χ(2)) test was then used to identify possible potential risk factors associated with asthma. Logistic regression analysis was then applied to determine the various potential risk factors associated with asthma. Data were entered and analyzed using SPSS (version 17) statistical analysis software. The significant level in this study was considered 0.05.

Results: The overall prevalence of asthma among school children was 4.9%, but in males it was 5.5% and in females - 4.3%. Also findings have demonstrated that prevalence of asthma was higher among 13-14 years age group (6.1%) as compared to children aged 6-7 (3.7%). The prevalence of wheeze in the last 12 months, wheeze after exercise and playing was 18.1%, 13.9%, and 8.4% respectively. Prevalence of dry cough at night was reported in 17.6%. Prevalence of asthma was highest in winter (2.6%).

Conclusions: Prevalence of asthma in children was higher in males than females and prevalence of allergic symptoms will be increased with high air pollution. Family history of asthma was a strong risk factor for childhood asthma.
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http://dx.doi.org/10.5114/pdia.2015.53322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565841PMC
August 2015

Prevention of nausea and vomiting: methods and utility after surgery in cancer patients?

Asian Pac J Cancer Prev 2015 ;16(7):2629-35

Department of Anesthesiology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran E-mail :

Most cancer patients experience nausea and vomiting after surgery. Today, many methods of treatment have been developed and used for the control of such symptoms. The most important are drug therapy, relaxation, oxygen therapy and gas therapy. In addition, dexamethasone, massage therapy and using a Venturi mask have also proven effective. Due to the nature of gas consumption which leads to nausea it is recommended that use of N2O in the operating room be avoided or applied in combination with oxygen or other gases with fewer complications.
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http://dx.doi.org/10.7314/apjcp.2015.16.7.2629DOI Listing
January 2016

Lack of association between using aspirin and development of non-Hodgkins lymphoma: a meta-analysis.

Asian Pac J Cancer Prev 2015 ;16(2):787-92

Social Determinants of Heath Research Center, School of Public Heath, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran E-mail :

Background: Non-Hodgkins lymphoma (NHL) is a heterogeneous group of malignancies, originating in the lymphatic organs, whose incidence is increasing in developed as well as developing countries. Epidemiological evidence suggests that aspirin may reduce the incidence and mortality of several cancers. The main objective of this study was to evaluate the potential relationship between using aspirin and development of NHL with a meta-analysis.

Materials And Methods: A total of 7 studies were included. Outcome was calculated and reported as odds ratios (ORs). Heterogeneity was assessed with Cochrane Q and I2 statistics. Dissemination bias was evaluated by funnel plot visualization and trim-and-fill analysis.

Results: Our analysis showed OR of developing NHL overall of 1(95% CI: 0.87-1.16, p=0.9), and in females this was 0.81 (95%CI: 0.72-.92, p=0.001) and in males 1.01 (95%CI: 0.82-1.26, p=0.86). The odds ratio (OR) of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) was 0.85 (95%CI: 0.75-0.97, p=0.02), The ORs of follicular lymphoma (FL) and large B-cell lymphoma (DLBCL) in individuals exposed to aspirin were 1.12 (95%CI: 0.86-1.45, p=0.37) and 1.03 (95%CI: 0.9-1.19, p=0.6) respectively.

Conclusions: In conclusion, individuals taking aspirin do not demonstrate any change in risk of Non-Hodgkins lymphoma.
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http://dx.doi.org/10.7314/apjcp.2015.16.2.787DOI Listing
December 2015

Cardiac Surgery Anesthesia And Systemic Inflammatory Response.

Int J Bioassays 2015 ;4(2):3648-3655

Toxicologist, Departments of Toxicology, Shahreza Branch, Islamic Azad University, Shahreza, Iran and Medical Research Center, Jundishapur Health Development Co, Tehran, Iran.

Cardiac surgery is associated with the development of a systemic inflammatory response. Inflammation represents the response of the body to tissue injury and in normal circumstances is a controlled humoral and cellular response that will lead to control of infection and wound healing. In some instances this response may become exaggerated, ultimately leading to additional tissue injury and the development of organ dysfunction. In this paper we discuss about relationships between cardiac surgery anesthesia and systemic inflammatory response.
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http://dx.doi.org/10.21746/ijbio.2015.02.005DOI Listing
January 2015

Predicting genes involved in human cancer using network contextual information.

J Integr Bioinform 2012 Sep 5;9(1):210. Epub 2012 Sep 5.

Leiden Institute of Advanced Computer Science, Universiteit Leiden, Niels Bohrweg 1, 2333 CA Leiden, The Netherlands.

Protein-Protein Interaction (PPI) networks have been widely used for the task of predicting proteins involved in cancer. Previous research has shown that functional information about the protein for which a prediction is made, proximity to specific other proteins in the PPI network, as well as local network structure are informative features in this respect. In this work, we introduce two new types of input features, reflecting additional information: (1) Functional Context: the functions of proteins interacting with the target protein (rather than the protein itself); and (2) Structural Context: the relative position of the target protein with respect to specific other proteins selected according to a novel ANOVA (analysis of variance) based measure. We also introduce a selection strategy to pinpoint the most informative features. Results show that the proposed feature types and feature selection strategy yield informative features. A standard machine learning method (Naive Bayes) that uses the features proposed here outperforms the current state-of-the-art methods by more than 5% with respect to F-measure. In addition, manual inspection confirms the biological relevance of the top-ranked features.
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http://dx.doi.org/10.2390/biecoll-jib-2012-210DOI Listing
September 2012

N-(1,3-Thia-zol-2-yl)benzamide.

Acta Crystallogr Sect E Struct Rep Online 2009 Mar 25;65(Pt 4):o817. Epub 2009 Mar 25.

The title compound, C(10)H(8)N(2)OS, features a nonplanar mol-ecule [dihedral angle between the two aromatic rings = 43.6 (1)°]. Two mol-ecules are linked by N-H⋯N hydrogen bonds about a centre of inversion, giving rise to a hydrogen-bonded dimer.
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http://dx.doi.org/10.1107/S1600536809009374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2969069PMC
March 2009

4-(5-Bromo-2-hydroxy-phen-yl)but-3-ene-2-one.

Acta Crystallogr Sect E Struct Rep Online 2009 Mar 19;65(Pt 4):o795. Epub 2009 Mar 19.

The molecule of the title compound, C(10)H(9)BrO(2), a doubly conjugated unsaturated ketone, is almost planar (r.m.s. deviation of the non-H atoms = 0.039 Å). In the crystal structure, two mol-ecules are linked across a centre of inversion to form a hydrogen-bonded dimer by way of two O-H⋯O links.
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http://dx.doi.org/10.1107/S1600536809009386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2969058PMC
March 2009