Publications by authors named "Hongyu Wang"

380 Publications

Progressive global perception and local polishing network for lung infection segmentation of COVID-19 CT images.

Pattern Recognit 2021 Dec 11;120:108168. Epub 2021 Jul 11.

Department of Health Administration and Policy, George Mason University, Fairfax, VA 22030, United States.

In this paper, a (PCPLP) network is proposed to automatically segment the COVID-19-caused pneumonia infections in (CT) images. The proposed PCPLP follows an encoder-decoder architecture. Particularly, the encoder is implemented as a computationally efficient (FCN). In this study, a (mmFRA) network is used to integrate multi-scale features (viz. global guidance features and local refinement features) with multi-level features (viz. high-level semantic features, middle-level comprehensive features, and low-level detailed features). Because of this innovative aggregation of features, an edge-preserving segmentation map can be produced in a (BMS) way. Furthermore, both global perception and local perception are devised. On the one hand, a (GPM) providing a holistic estimation of potential lung infection regions is employed to capture more complementary coarse-structure information from different pyramid levels by enlarging the receptive fields without substantially increasing the computational burden. On the other hand, a (LPM), which provides a fine prediction of the segmentation regions, is applied to explicitly heighten the fine-detail information and reduce the dilution effect of boundary knowledge. Comprehensive experimental evaluations demonstrate the effectiveness of the proposed PCPLP in boosting the learning ability to identify the lung infected regions with clear contours accurately. Our model is superior remarkably to the state-of-the-art segmentation models both quantitatively and qualitatively on a real CT dataset of COVID-19.
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http://dx.doi.org/10.1016/j.patcog.2021.108168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8272691PMC
December 2021

How Capital Endowment and Ecological Cognition Affect Environment-Friendly Technology Adoption: A Case of Apple Farmers of Shandong Province, China.

Int J Environ Res Public Health 2021 07 16;18(14). Epub 2021 Jul 16.

Department of Economics & Management, College of Economics & Management, Shandong Agricultural University, Tai'an 271018, China.

Ever-increasing global environmental issues, land degradation, and groundwater contamination may significantly impact the agricultural sector of any country. The situation worsens while the global agricultural sectors are going through the unsustainable intensification of agricultural production powered by chemical fertilizers and pesticides. This trend leads the sector to exercise environmentally friendly technology (EFT). Capital endowment and ecological cognition may significantly impact fostering farmers' adoption of environmentally friendly technology. The government also tends to change the existing policies to cope with ever-increasing challenges like pollution control, maintaining ecological balance, and supporting agricultural sectors substantially by employing ecological compensation policy. The study's main objective is to explore the impacts of farmer's ecological compensation, capital endowment, and ecological cognition for the adoption of EFT. The empirical setup of the study quantifies with survey data of 471 apple farmers from nine counties of Shandong province. The study used Heckman's two-stage model to craft the findings. The results showed that 52.02% of fruit farmers adopted two environmentally friendly technologies, and 23.99% of fruit farmers adopted three forms of environmentally friendly technologies. At the same time, we have traced that the capital endowment, planting scale, family income, and technical specialization of fruit farmers significantly impact adopting EFT. The study also revealed that understanding ecological compensation policy has a significant positive effect on adopting environmentally friendly technology. Seemingly, ecological compensation policy has a specific regulatory effect on fruit farmers' capital endowment and ecological cognition. Therefore, it is necessary to extend the demonstration facilities, training, and frequently arrange awareness-building campaigns regarding rural non-point source pollution hazards and improve the cognition level of farmers. The agriculture extension department should strengthen the agricultural value chain facilities to make farmers fully realize the importance of EFT. Government should promote and extend the supports for availing new and innovative EFT at a reasonable price. Moreover, cooperative, financial, and credit organizations need to lead for the smooth transition of EFT. The agricultural cooperatives and formal risk-taking networks should act responsibly for shaping the behavioral factors of farmers.
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http://dx.doi.org/10.3390/ijerph18147571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8305192PMC
July 2021

Fluorescent Supramolecular Organic Frameworks Constructed by Amidinium-Carboxylate Salt Bridges.

Chemistry 2021 Jul 20. Epub 2021 Jul 20.

Shanghai University, Department of chemistry, CHINA.

We report here a set of fluorescent supramolecular organic frameworks (SOFs) that incorporate aggregation-induced emission (AIE) units within their frameworks. The fluorescent SOFs of this study were constructed by linking the tetraphenylethylene (TPE)-based tetra(amidinium) cation TPE 4+ and aromatic dicarboxylate anions through amidinium-carboxylate salt bridges. The resulting self-assembled structures are characterized by fluorescence quantum yields in the range of 4.6%~14%. This emissive behavior is ascribed to a combination of electrostatic and hydrogen bonding interactions that operate in concert to impede motions that would otherwise lead to excited state energy dissipation. Single crystal X-ray diffraction analyses revealed that the length of dicarboxylate anion bridges has a considerable impact on the structural features of the resulting frameworks. Nevertheless all SOFs prepared in the context of the present study were found display emissive features characteristic of TPE-based AIE luminogens with only a modest dependence on the structural specifics being seen. The SOFs reported here could be reversibly "broken up" and "reformed" in response to acid/base stimuli.
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http://dx.doi.org/10.1002/chem.202102296DOI Listing
July 2021

Combining Experiments and Theoretical Calculations to Investigate the Intercalation Behavior of Bis(trifluoromethanesulfonimide) Anion into Graphite Electrodes from Alkyl Phosphates.

ACS Appl Mater Interfaces 2021 Jul 14;13(29):34197-34201. Epub 2021 Jul 14.

State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, China.

In dual-ion batteries (DIBs) utilizing organic electrolyte solutions, the combinations of electrolyte salt and solvent serve as a determiner of the electrochemical performance of graphite electrode partially because solvent participates in the anion intercalation procedure. In this case, every [email protected] intercalation compound possesses the characteristic intercalated gallery height. However, in Li/graphite DIBs with concentrated LiTFSI (lithium bis(trifluoromethanesulfonimide))-alkyl phosphates (ca. trimethyl, triethyl, tripropyl, tributyl phosphate) solutions, [email protected] intercalation compounds have the nearly identical intercalated gallery height of about 0.803 nm, which may be mainly attributed to both the big size of TFSI anion and the rigid PO framework of these alkyl phosphate solvents.
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http://dx.doi.org/10.1021/acsami.1c07222DOI Listing
July 2021

Computational study on novel natural inhibitors targeting BCL2.

Med Oncol 2021 Jul 14;38(8):94. Epub 2021 Jul 14.

Department of Neurosurgery, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, China.

Ideal lead compounds and candidate drugs with inhibitory effect on BCL2 were screened from ZINC database, which laid a foundation for drug development and compound improvement of drug treatment for diffuse large B-cell lymphoma (DLCBL). Identification of potential BCL2 inhibitors by computer-aided virtual screening. Libdock was applied to 17,931 compounds and the top 20 were selected for further analysis. Selected compounds were performed absorption, distribution, metabolism, and excretion (ADME) and toxicity prediction. The binding affinity between the selected ligands and BCL2 was confirmed by Molecular docking. The new natural compounds, ZINC00000255131 and ZINC00013298233, were found to bind closely with BCL2. Furthermore, they all scored lower in ames-induced mutagenicity, rodent carcinogenicity, non-developmental toxicity potential, and cytochrome P4502D6 tolerance. Molecular dynamics simulation shows that the combinations of ZINC00000255131 and ZINC00013298233 with BCL2 in the natural environment are more stable. Two new compounds, ZINC00000255131 and ZINC00013298233, were found to be potential inhibitors of BCL2. These compounds have been proved to be safe, which is of great significance for the development and improvement of DLCBL drugs.
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http://dx.doi.org/10.1007/s12032-021-01513-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8280014PMC
July 2021

Novel natural inhibitors targeting B-RAF(V600E) by computational study.

Bioengineered 2021 Dec;12(1):2970-2983

Department of Orthopaedics, the First Bethune Hospital of Jilin University, Street Xinmin 71, Changchun, China.

The aim of this research was to screen the ZINC15 database to select lead compounds and drug candidates which can inhibit B-RAF (V600E). In order to identify drugs potentially inhibited B-RAF (V600E), numerous modules of Discovery Studio 4.5 were employed. Structure-based screening using LibDock was carried out followed by ADME (absorption, distribution, metabolism, excretion) and toxicity prediction. CDOCKER was performed to demonstrate the binding affinity and mechanism between ligands and B-RAF(V600E). To evaluate whether ligand-receptor complexes were stable, molecular dynamics were employed. Two novel natural compounds (ZINC000100168592 and ZINC000049784088) from ZINC15 database were found binding to B-RAF(V600E) with more favorable interaction energy in comparison with the reference drug Vemurafenib. Also, they were predicted with less ames mutagenicity, rodent carcinogenicity, non-developmental toxic potential and tolerance to cytochrome P450 2D6 (CYP2D6). The molecular dynamics simulation analysis indicated that the compound-B-RAF(V600E) complexes had more favorable potential energy compared with Vemurafenib and they can exist in natural environments stably. The result of this study shows that ZINC000100168592 and ZINC000049784088 are ideal leading potential compounds to inhibit B-RAF(V600E). The findings of this study and these selected drug candidates greatly contributed to the medication design and improvement of B-RAF(V600E) and other proteins.
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http://dx.doi.org/10.1080/21655979.2021.1943113DOI Listing
December 2021

Metabolome-Microbiome Responses of Growing Pigs Induced by Time-Restricted Feeding.

Front Vet Sci 2021 22;8:681202. Epub 2021 Jun 22.

Laboratory of Gastrointestinal Microbiology, Jiangsu Key Laboratory of Gastrointestinal Nutrition and Animal Health, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China.

Time-restricted feeding (TRF) mode is a potential strategy in improving the health and production of farm animals. However, the effect of TRF on microbiota and their metabolism in the large intestine of the host remains unclear. Therefore, the present study aimed to investigate the responses of microbiome and metabolome induced by TRF based on a growing-pig model. Twelve crossbred growing barrows were randomly allotted into two groups with six replicates (1 pig/pen), namely, the free-access feeding group (FA) and TRF group. Pigs in the FA group were fed free access while the TRF group were fed free access within a regular time three times per day at 07:00-08:00, 12:00-13:00, and 18:00-19:00, respectively. Results showed that the concentrations of NH4-N, putrescine, cadaverine, spermidine, spermine, total biogenic amines, isobutyrate, butyrate, isovalerate, total SCFA, and lactate were increased while the pH value in the colonic digesta and the concentration of acetate was decreased in the TRF group. The Shannon index was significantly increased in the TRF group; however, no significant effects were found in the Fisher index, Simpson index, ACE index, Chao1 index, and observed species between the two groups. In the TRF group, the relative abundances of and were significantly increased while the relative abundances of , and were decreased compared with the FA group. PLS-DA analysis revealed an obvious and regular variation between the FA and TRF groups, further pathway enrichment analysis showed that these differential features were mainly enriched in pyrimidine metabolism, nicotinate and nicotinamide metabolism, glycerolipid metabolism, and fructose and mannose metabolism. In addition, Pearson's correlation analysis indicated that the changes in the microbial genera were correlated with the colonic metabolites. In conclusion, these results together indicated that although the overall microbial composition in the colon was not changed, TRF induced the gradient changes of the nutrients and metabolites which were correlated with certain microbial genera including group, group, 1, and sensu sticto 1. However, more studies are needed to understand the impacts of TRF on the health and metabolism of growing pigs.
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http://dx.doi.org/10.3389/fvets.2021.681202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8258120PMC
June 2021

Enantioselectivity switch in asymmetric Michael addition reactions using phosphonium salts.

Org Biomol Chem 2021 Jul;19(28):6334-6340

Department of Chemistry, University of Science and Technology of China, Hefei 230026, Anhui, China. and Center for Excellence in Molecular Synthesis, Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 LingLing Road, Shanghai 200032, China.

Efficient access to two enantiomers of one chiral compound is critical for the discovery of drugs. However, it is still a challenging problem owing to the difficulty in obtaining two enantiomers of one chiral catalyst. Here, we report a general method to obtain both enantiomeric products via fine tuning the hydrogen-bonding interactions of phosphonium salts. Amino acid derived phosphonium salts and dipeptide derived phosphonium salts exhibited different properties for controlling the transition state, which could efficiently promote the Michael addition reaction to give opposite configurations of products with high yields and enantioselectivities. Preliminary investigations on the mechanism of the reaction and applications of the products were also performed.
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http://dx.doi.org/10.1039/d1ob01027aDOI Listing
July 2021

Goose Nephritic Astrovirus Infection of Goslings Induces Lymphocyte Apoptosis, Reticular Fiber Destruction, and CD8 T-Cell Depletion in Spleen Tissue.

Viruses 2021 06 9;13(6). Epub 2021 Jun 9.

MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.

The emergence of a novel goose nephritic astrovirus (GNAstV) has caused economic losses to the Chinese goose industry. High viral load is found in the spleen of goslings infected with GNAstV, but pathological injuries to the spleen due to GNAstV are largely unknown. In this study, 50 two-day-old goslings were infected orally with GNAstV, and 50 goslings were treated with PBS as control. Spleens were collected at different times following infection to assess damage. GNAstV infection caused visceral gout and urate deposition in joints, and resulted in 16% mortality. GNAstV was found in the lymphocytes and macrophages within the spleen. Lymphocyte loss, especially around the white pulp, and destruction and decline in the number of reticular fibers was observed in GNAstV-infected goslings. Moreover, in GNAstV-infected goslings, ultrahistopathological examination found that splenic lymphocytes exhibited condensed chromatin and apoptotic bodies, and reticular cells displayed damage to plasma membrane integrity and swollen mitochondria. Furthermore, TUNEL staining confirmed apoptosis of lymphocytes, and the mRNA levels of Fas and FasL were significantly increased in the GNAstV-infected goslings. In addition, GNAstV infection reduced the number and protein expression of CD8. In conclusion, GNAstV infection causes lymphocyte depletion, reticular cell necrosis, reticular fiber destruction, lymphocyte apoptosis, and reduction in CD8 levels, which contribute to spleen injury.
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http://dx.doi.org/10.3390/v13061108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8229047PMC
June 2021

Achieved educational attainment, inherited genetic endowment for education, and obesity.

Biodemography Soc Biol 2021 Apr-Jun;66(2):132-144

Department of Sociology, University of North Carolina, Chapel Hill, North Carolina, USA.

This study investigates two sources of education effects on obesity - achieved educational attainment and inherited genetic endowment for education. In doing so, we accomplish two goals. First, we assess the role of genetic confounding in the association between education and health. Second, we consider the heterogeneity in the extent to which genetic potential for education is realized, and we examine its impact on obesity. Data come from the National Longitudinal Study of Adolescent to Adult Health. Using a polygenic score approach, we find that, net of genetic confounding, holding a college degree is associated with a lower likelihood of obesity. Moreover, among individuals who hold a college degree, those with a high education polygenic score (a greater genetic propensity to succeed in education) are less likely to be obese than those with a relatively low education polygenic score. However, when individuals with a high education polygenic score do not have a college degree, their risk of obesity is similar to that of non-college-educated individuals with a low education polygenic score, suggesting that the effect of genetic endowment for education on obesity is conditional on college education.
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http://dx.doi.org/10.1080/19485565.2020.1869919DOI Listing
June 2021

Dose-Response Relationship Between Long-Term Blood Pressure Variability and Cognitive Decline.

Stroke 2021 Jun 25:STROKEAHA120033697. Epub 2021 Jun 25.

Peking University Clinical Research Institute, Peking University First Hospital, Beijing, China (C.L., Y.M., R.H., W.X.).

Background And Purpose: We aimed to test whether higher long-term blood pressure variability was associated with accelerated rate of cognitive decline and evaluate potential dose-response relationship.

Methods: Original survey data from the Health and Retirement Study and the English Longitudinal Study of Ageing were used. Standardized score of cognitive function was the main outcome measure. Visit-to-visit blood pressure SD, coefficient of variation, and variation independent of mean were used. Linear mixed model and restricted spline were applied to assess association and explore dose-response pattern. Segmented regression was used to analyze dose-response relationship and estimate turning point. Meta-analysis using random-effects model was conducted to pool results, with used to test heterogeneity.

Results: A total of 12 298 dementia-free participants were included (mean age: 64.6±8.6 years). Significant association was observed between blood pressure variability and cognitive decline. Each 10% increment in coefficient of variation of systolic and diastolic blood pressure was associated with accelerated global cognitive decline of 0.026 SD/y (95% CI, 0.016-0.036, 0.001) and 0.022 SD/y (95% CI, 0.017-0.027, 0.001), respectively. Nonlinear dose-response relationship was found (0.001 for nonlinearity), with clear turning point observed (0.001 for change in slopes).

Conclusions: Higher long-term blood pressure variability was associated with accelerated cognitive decline among general adults aged ≥50 years, with nonlinear dose-response relationship. Further randomized controlled trials are warranted to evaluate potential benefits of blood pressure variability-lowering strategies from a cognitive health perspective.
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http://dx.doi.org/10.1161/STROKEAHA.120.033697DOI Listing
June 2021

Clinical acupuncture therapy for femur head necrosis: A protocol for systematic review and meta analysis.

Medicine (Baltimore) 2021 Jun;100(25):e26400

The Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, China.

Background: Femur Head Necrosis (FHN) is a common clinical joint orthopedic-related disease, and its incidence is increasing year by year. Symptoms include dull pain and dull pain in the affected hip joint or its surrounding joints. More severely, it can lead to limited joint movement and inability to walk autonomously. Surgical treatment has many sequelae. The high cost makes it unaffordable for patients, and the side effects of drug treatment are unknown. A large number of clinical studies have shown that acupuncture is effective in treating femoral head necrosis. Therefore, this systematic review aims to explore the safety and effectiveness of acupuncture in the treatment of femoral head necrosis.

Methods: We will conduct a comprehensive literature search in Medline, PubMed, Cochrane Database of Systematic Reviews, Embase, Chinese Biomedical Literatures Database (CBM), China National Knowledge Infrastructure (CNKI), Wang FangDatabase (WF), Chinese Scientific Journal Database (VIP) from inception to May 2021 without any language restriction. In addition, we will retrieve the unpublished studies and the references of initially included literature manually. The two reviewers will identify studies, extract data, and assess the quality independently. The outcomes of interest include: total effective rate; the total nasal symptom score; Hip function (Hip Harris joint score, WOMAC hip score, hip joint Lequesne index score, Merle D 'Aubigne and hip joint Postel score); Adverse events. Randomized clinical trials will be collected, methodological quality will be evaluated using the Cochrane risk-of-bias assessment tool, and the level of evidence will be rated using the Grading of Recommendations, Assessment, Development and Evaluation approach. Meta-analysis will be performed using RevMan 5.4.0 software. The heterogeneity test will be conducted between the studies, P < .1 and I2 > 50% are the thresholds for the tests. We will utilize the fixed effects model or the random effects model according to the size of heterogeneity.

Results: The meta-analysis program will systematically evaluate the efficacy and safety of acupuncture in the treatment of FHN patients.

Conclusion: This study will investigate whether acupuncture can be used as one of the non-surgical and non-pharmacological therapies for the prevention or treatment of FHN.

Trial Registration Number: INPLASY202150035.
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http://dx.doi.org/10.1097/MD.0000000000026400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238343PMC
June 2021

Catalytic Regioselective Olefin Hydroarylation(alkenylation) by Sequential Carbonickelation-Hydride Transfer.

J Am Chem Soc 2021 Jun 21;143(25):9498-9506. Epub 2021 Jun 21.

Department of Chemistry, National University of Singapore, 4 Science Drive 2, Singapore, 117544, Republic of Singapore.

Alkene hydrocarbofunctionalization represents one of the most important classes of chemical transformations, but related branched-selective examples with unactivated olefins are scarce. Here, we report that catalytic amounts of a dimeric Ni(I) complex and an exogenous alkoxide base promote Markovnikov-selective hydroarylation(alkenylation) of unactivated and activated olefins using organo bromides or triflates derived from widely available phenols and ketones. Products bearing aryl- and alkenyl-substituted tertiary and quaternary centers could be isolated in up to 95% yield and >99:1 regioisomeric ratios. Contrary to previous dual-catalytic methods that rely on metal-hydride atom transfer (MHAT) to the olefin prior to carbofunctionalization with a cocatalyst, our mechanistic evidence points toward a nonradical reaction pathway that begins with site-selective carbonickelation across the C═C bond followed by hydride transfer using alkoxide as the hydride source. Utility of the single-catalyst protocol is highlighted through the synthesis of medicinally relevant scaffolds.
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http://dx.doi.org/10.1021/jacs.1c03228DOI Listing
June 2021

Efficient heavy metal removal from water by alginate-based porous nanocomposite hydrogels: The enhanced removal mechanism and influencing factor insight.

J Hazard Mater 2021 Jun 8;418:126358. Epub 2021 Jun 8.

School of Hydraulic Engineering, Changsha University of Science & Technology, Changsha 410114, China; Key Laboratory of Dongting Lake Aquatic Eco-Environmental Control and Restoration of Hunan Province, Changsha 410114, China. Electronic address:

Novel porous alginate-based nanocomposite hydrogels were prepared by incorporating polyaniline-polypyrrole modified graphene oxide ([email protected]) as reinforcing fillers into the alginate matrix ([email protected]/SA) for Cr(VI) and Cu(II) removal from water. Different in-situ co-polymerization functionalized GO with Py-to-An mass ratios of monomers (from nil to 1:1) and contents of [email protected] (from nil to 2.0%(w/v)) were embedded into the alginate backbone to improve the sorption performance. Key factors, such as pH, coexisting metal ions, and swelling states were investigated in batch adsorption modes. The synergistic effect combined from polymer backbone and fillers could lower the impact of the pH-dependent adsorption reaction. With an adsorption ability superior to that of plain SA and GO/SA, the optimized [email protected](1)/SA exhibited good experimental maximum adsorption capacities for Cr(VI) (~133.7 mg/g) and Cu(II) (~87.2 mg/g) at pH 3.0, which were better than those of many other similar sorbents. The sorbents possessed excellent adaptability for 0.2 M salt for Cr(VI) removal but poor for Cu(II) removal. Pre-swelling treatment and co-adsorption could enhance the adsorption performance. The excellent reusability of hydrogel was demonstrated after five cycles in single/binary system. Overall, this work reveals that the resultant hydrogel holds potential as candidate sorbent to remove anionic-cationic heavy metal ions from water.
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http://dx.doi.org/10.1016/j.jhazmat.2021.126358DOI Listing
June 2021

Dual-targeted photothermal agents for enhanced cancer therapy.

Chem Sci 2020 Jul 17;11(31):8055-8072. Epub 2020 Jul 17.

College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Centre of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University Jinan 250014 P. R. China

Photothermal therapy, in which light is converted into heat and triggers local hyperthermia to ablate tumors, presents an inherently specific and noninvasive treatment for tumor tissues. In this area, the development of efficient photothermal agents (PTAs) has always been a central topic. Although many efforts have been made on the investigation of novel molecular architectures and photothermal materials over the past decades, PTAs can cause severe damage to normal tissues because of the poor tumor aggregate ability and high irradiation density. Recently, dual-targeted photothermal agents (DTPTAs) provide an attractive strategy to overcome these problems and enhance cancer therapy. DTPTAs are functionalized with two classes of targeting units, including tumor environment targeting sites, tumor targeting sites and organelle targeting sites. In this perspective, typical targeted ligands and representative examples of photothermal therapeutic agents with dual-targeted properties are systematically summarized and recent advances using DTPTAs in tumor therapy are highlighted.
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http://dx.doi.org/10.1039/d0sc03173aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163445PMC
July 2020

The circular RNA circSPARC enhances the migration and proliferation of colorectal cancer by regulating the JAK/STAT pathway.

Mol Cancer 2021 06 1;20(1):81. Epub 2021 Jun 1.

Department of General Surgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, Jiangsu Province, China.

Background: Noncoding RNAs such as circular RNAs (circRNAs) are abundant in the human body and influence the occurrence and development of various diseases. However, the biological functions of circRNAs in colorectal cancer (CRC) are largely unknown.

Methods: RT-qPCR was used to detect the expression of circRNAs and mRNA in CRC cells and tissues. Fluorescence in situ hybridization (FISH) was used to analyze the location of circSPARC. Function-based experiments were performed using circSPARC knockdown and overexpression cell lines in vitro and in vivo, including CCK8, colony formation, transwell and metastasis models. Mechanistically, luciferase reporter assay, western blots, RNA immunoprecipitation (RIP), Chromatin isolation by RNA purification (ChIRP) and immunohistochemical stainings were performed.

Results: CircSPARC was upregulated in both the tissues and plasma of CRC patients. High expression of circSPARC was associated with advanced TNM stage, lymph node metastases, and poor survival. Silencing circSPARC inhibited CRC cell migration and proliferation in vitro and vivo. Mechanistically, circSPARC sponged miR-485-3p to upregulate JAK2 expression and ultimately contribute to the accumulation of phosphorylated (p)-STAT3. Besides, circSPARC recruited FUS, which facilitated the nuclear translocation of p-STAT3.

Conclusions: These findings suggest that circSPARC might serve as a potential diagnostic and prognostic biomarker and a therapeutic target for CRC treatment by regulating JAK2/STAT3 pathway.
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http://dx.doi.org/10.1186/s12943-021-01375-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8167978PMC
June 2021

Multi-Sensor Perception Strategy to Enhance Autonomy of Robotic Operation for Uncertain Peg-in-Hole Task.

Sensors (Basel) 2021 May 31;21(11). Epub 2021 May 31.

School of Electrical Engineering, Yanshan University, Qinhuangdao 066012, China.

The peg-in-hole task with object feature uncertain is a typical case of robotic operation in the real-world unstructured environment. It is nontrivial to realize object perception and operational decisions autonomously, under the usual visual occlusion and real-time constraints of such tasks. In this paper, a Bayesian networks-based strategy is presented in order to seamlessly combine multiple heterogeneous senses data like humans. In the proposed strategy, an interactive exploration method implemented by hybrid Monte Carlo sampling algorithms and particle filtering is designed to identify the features' estimated starting value, and the memory adjustment method and the inertial thinking method are introduced to correct the target position and shape features of the object respectively. Based on the Dempster-Shafer evidence theory (D-S theory), a fusion decision strategy is designed using probabilistic models of forces and positions, which guided the robot motion after each acquisition of the estimated features of the object. It also enables the robot to judge whether the desired operation target is achieved or the feature estimate needs to be updated. Meanwhile, the pliability model is introduced into repeatedly perform exploration, planning and execution steps to reduce interaction forces, the number of exploration. The effectiveness of the strategy is validated in simulations and in a physical robot task.
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http://dx.doi.org/10.3390/s21113818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198270PMC
May 2021

Anterior Gradient Protein 2 Promotes Mucosal Repair in Pediatric Ulcerative Colitis.

Biomed Res Int 2021 18;2021:6483860. Epub 2021 May 18.

Department of Pediatrics, China Medical University Affiliated with Shengjing Hospital, Shenyang, 110004 Liaoning, China.

Mucosal healing comprises a key goal of ulcerative colitis (UC) treatment. Anterior gradient protein 2 (AGR2) plays an important role in maintaining intestinal homeostasis in UC. However, the role of AGR2 in the repair of mucosal injury is not yet clear. This study is aimed at investigating the expression of AGR2 in the intestinal tissues of children with UC and its role in repairing mucosal injury. Forty UC patients who were hospitalized in the Pediatric Gastroenterology Ward of Shengjing Hospital affiliated with China Medical University between July 1, 2013, and May 31, 2020, and 20 children who had normal colonoscopy results during the same period (control group) made up the study sample. The disease activity of UC was evaluated based on the pediatric ulcerative colitis activity index, and the ulcerative colitis endoscopic index was evaluated according to the Rachmilewitz score. Immunohistochemical staining was employed to examine the differences in AGR2 expression in the intestinal mucosa between groups. The protective effect of AGR2 in a model of tumor necrosis factor-alpha- (TNF--) induced intestinal mucosal barrier injury and the underlying molecular mechanism were explored through experiments. The results showed that compared with the normal control group, UC patients in the remission or active period had significantly higher expression of AGR2 in the intestine. AGR2 expression was positively correlated with Ki67, an intestinal epithelial cell proliferation marker, but negatively correlated with the degree of endoscopic mucosal injury. In an model, AGR2 overexpression promoted cell proliferation and migration and inhibited TNF--induced intestinal epithelial barrier damage by activating yes-associated protein (YAP). Collectively, our study suggests that AGR2 might serve as a valuable biomarker to help assess the condition and mucosal healing status of UC patients. , AGR2 promoted the repair of intestinal mucosal barrier injury by activating YAP.
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http://dx.doi.org/10.1155/2021/6483860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8149229PMC
May 2021

Integrated Strategy of Network Pharmacological Prediction and Experimental Validation Elucidate Possible Mechanism of Bu-Yang Herbs in Treating Postmenopausal Osteoporosis via ESR1.

Front Pharmacol 2021 11;12:654714. Epub 2021 May 11.

Graduated School, Jiangxi University of Chinese Medicine, Nanchang, China.

Postmenopausal osteoporosis (PMOP) is a type of bone metabolism disease-related to estrogen deficiency with an increasing incidence. Traditional Chinese (TCM) has always been used and showed effectiveness in treating PMOP. In the current study, Bu-Yang herbs were considered to be the most frequently used and efficient TCM herbs in PMOP treatment. However, chemical and pharmacological profiles were not elucidated. Network pharmacology was conducted on representative Bu-Yang herbs (Yin-Yang-Huo. Du-Zhong, Bu-Gu-Zhi, Tu-Si-Zi) to investigate the mechanism of Bu-Yang herbs on PMOP. Chemical compounds, potential targets, and disease related genes were available from the corresponding database. Results showed that Bu-Yang herbs could interact with ESR1 and estrogen signaling pathways. For further validation, the Bu-Yang decoction (BYD), formula consisted of the above-mentioned 4 Bu-Yang herbs was presented for experimental validation. , BYD significantly reversed ovariectomy (OVX)-induced osteoporosis progress in a dose-dependent manner by up-regulation of bone mineral density and amelioration of bone microarchitecture. , BYD dramatically improved the proliferation and mineral nodules formation of osteoblasts. Both and results illustrated that the phenotype change induced by BYD is correlated with up-regulated of ESR1 and activation of the β-catenin pathway. Meanwhile, inhibition of ESR1 by ICI182, 780 blocked the osteogenic phenotype and β-catenin pathway activation induced by BYD. In conclusion, the current study suggested that Bu-Yang herbs are the most useful TCM herbs in treating PMOP. Furthermore, the integrated strategy of network pharmacology prediction with experimental validation suggested that BYD exerted its anti-PMOP via ESR1 and the downstream mechanism might be activation of the β-catenin signaling pathway.
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http://dx.doi.org/10.3389/fphar.2021.654714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144472PMC
May 2021

Surface Wettability of Nanoparticle Modulated Sonothrombolysis.

Adv Mater 2021 Jun 13;33(25):e2007073. Epub 2021 May 13.

Beijing Advanced Innovation Center for Soft Matter Science and Engineering, State Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, Bionanomaterials & Translational Engineering Laboratory, Beijing Key Laboratory of Bioprocess, Beijing University of Chemical Technology, Beijing, 100029, P. R. China.

Sonodynamic therapy (SDT) is a non-invasive and highly penetrating treatment strategy under ultrasound irradiation. However, uncertainty in the mechanism of SDT has seriously hindered its future clinical application. Here, the mechanism of SDT enhanced by the wettability of nanoparticles is investigated. Nanoparticles can adsorb and stabilize nanobubbles in liquid, thus enhancing SDT efficiency. The stability of the nanobubbles is positively correlated with the desorption energy of the nanoparticles, which is determined by the wettability of the nanoparticles. This conclusion is verified for mesoporous silica and polystyrene nanoparticles and it is found that nanoparticles with a water contact angle of about 90° possess the largest desorption energy. To further apply this conclusion, thrombus models are constructed on rats and the experimental results demonstrate that nanoparticles with the largest desorption energy have the highest thrombolytic efficiency. It is believed that these findings will help to better understand the SDT mechanism and guide new strategies for rational design of nanoparticles adopted in SDT.
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http://dx.doi.org/10.1002/adma.202007073DOI Listing
June 2021

An efficient strategy for cancer therapy using a tumor- and lysosome-targeted organic photothermal agent.

Nanoscale 2021 May;13(19):8790-8794

College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Centre of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University, Jinan, 250014, P. R. China.

A dual-targeted organic photothermal agent for tumor cells and lysosomes was developed. In vitro and in vivo experiments demonstrated that it possessed low cytotoxicity, good biological compatibility, and tumor inhibitory effects.
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http://dx.doi.org/10.1039/d1nr01547hDOI Listing
May 2021

Phenalen-1-one-mediated photodynamic therapy inhibits keloid graft progression by reducing vessel formation and promoting fibroblast apoptosis.

Adv Clin Exp Med 2021 Apr;30(4):431-439

Department of Burn Orthopedics, Xingtai People's Hospital, China.

Background: Keloid is a unique refractory syndrome characterized by a proliferation disorder of the fibroblasts. Recently, photodynamic therapy (PDT) has become a promising technique to modulate fibroblasts. However, use of the photosensitizer Phenalen-1-one (Ph1) in PDT for keloid remains to be explored.

Objectives: This study investigated the efficacy of Ph1-PDT in the in vitro and in vivo models of keloid.

Material And Methods: Cell viability was assessed with a Cell Counting Kit-8 (CCK-8) analysis in keloid fibroblasts. The migrated and invaded keloid fibroblasts after Ph1-PDT were detected using scratch and matrigel invasion assays in vitro. Flow cytometry measured the apoptosis changes. The protein concentrations and the mRNA expression of inflammatory modulators (interleukin 8 (IL-8) and IL-1β) were determined using enzyme-linked immunosorbent assay (ELISA) and real-time quantitative polymerase chain reaction (RT-qPCR) methods, respectively. Nude mice were used to perform the transplantation of keloid grafts. Western blot analysis measured the protein expression of CD31, CD34, tumor growth factor β1 (TGF-β1), and collagen 1 in keloid fibroblasts and grafts.

Results: Our results revealed that Ph1-PDT significantly suppressed cell viability, migration and invasion, and enhanced the rate of cell apoptosis and caspase-3 expression in keloid fibroblasts. Moreover, in the nude mice model, Ph1-PDT decreased the volume of the graft and attenuated the vessel density by inhibiting the expression of vessel density biomarkers (CD31 and CD34) in keloid grafts. Furthermore, Ph1-PDT significantly inactivated the inflammatory mediators in keloid grafts. In addition, Ph1-PDT considerably attenuated the development of keloids by inhibiting TGF-β1 and collagen 1 proteins in keloid fibroblasts and grafts.

Conclusions: Ph1-PDT may suppress keloid progression by reducing vessel formation and inflammation, and promoting fibroblast apoptosis, suggesting a potential therapy method for keloid.
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http://dx.doi.org/10.17219/acem/130594DOI Listing
April 2021

Excessive copper in feed not merely undermines animal health but affects food safety.

J Vet Sci 2021 May 17;22(3):e31. Epub 2021 Mar 17.

Laboratory of Zoonoses, China Animal Health and Epidemiology Center, Qingdao 266032, China.

Background: Blackened intestines in slaughtered pigs have been commonly observed in China in recent years. However, no cause has been reported.

Objectives: We attempted to determine whether the blackening of the pig intestine was related to an excess of copper (Cu) in their feed.

Methods: In this study, we observed and collected porcine intestines in small- and large-scale pig slaughterhouses in Shandong province from May to October 2018. Twelve types of metal ions were detected in the black intestinal samples.

Results: The Cu level in the intestine samples was mostly higher than the Chinese national limit for food. Further study showed that Cu supplementation in most commercial porcine feed also exceeded the national standard. An animal model (mouse) that could mimic the intestinal blackening in pigs was established. Compared to control mice, Cu accumulated in the liver and intestines of mice fed an excessive Cu level, confirming the excessive Cu in the feed may be considered the major cause of blackened porcine intestines. Microscopic examination revealed that black intestines had many particles containing Cu in the lamina propria of the intestinal mucosa, and the intestinal mucosal epithelial cells showed degeneration and necrosis.

Conclusions: In conclusion, overuse of Cu in animal feed can lead to animal poisoning and Cu accumulation in animal products. Such overuse not only harms the health of livestock but can also affect public health.
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http://dx.doi.org/10.4142/jvs.2021.22.e31DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8170218PMC
May 2021

Drug-eluting beads TACE is safe and non-inferior to conventional TACE in HCC patients with TIPS.

Eur Radiol 2021 Apr 24. Epub 2021 Apr 24.

Department of Interventional Oncology, The First Affiliated Hospital of Sun Yat-Sen University, 58 Zhongshan 2nd Road, Guangzhou, 510080, People's Republic of China.

Objectives: This study aims to compare the safety and effectiveness between transarterial chemoembolization (TACE) with drug-eluting beads (DEB-TACE) and conventional TACE (cTACE) using lipiodol-based regimens in HCC patients with a transjugular intrahepatic portosystemic shunt (TIPS).

Methods: This retrospective study included patients with patent TIPS who underwent TACE from January 2013 to January 2019 that received either DEB-TACE (DEB-TACE group, n = 57) or cTACE (cTACE group, n = 62). The complications, liver toxicity, overall survival (OS), time to progression (TTP), and objective response rate (ORR) were compared between the groups.

Results: Altogether, 119 patients (50 ± 11 years, 107 men) were evaluated. The incidence of adverse events, including abdominal pain within 7 days (45.6% vs 79.0%, p < 0.001) and hepatic failure within 30 days (5.3% vs 19.4%, p = 0.027), were significantly lower in the DEB-TACE group than in the cTACE group. Compared to the cTACE group, the DEB-TACE group also showed mild liver toxicities in terms of increased total bilirubin (8.8% vs 22.6%), alanine aminotransferase (5.3% vs 21.0%), and aspartate aminotransferase (10.5% vs 29.0%) levels. The DEB-TACE group had better ORR than the cTACE group (70.2% vs 50.0%). The median OS and TTP were longer in the DEB-TACE group (11.4 vs 9.1 months, hazard ratio [HR] = 2.46, p < 0.001; 6.9 vs 5.2 months, HR = 1.47, p = 0.045). Multivariable analysis showed that α-fetoprotein levels, Barcelona clinic liver cancer stage, and treatment allocation were independent predictors of OS.

Conclusion: DEB-TACE is safe and effective in HCC patients with a TIPS and is potentially superior to cTACE in terms of complications, liver toxicities, OS, TTP, and ORR.

Key Points: • DEB-TACE is safe and effective in HCC patients after a TIPS procedure. • DEB-TACE improves overall survival, objective response rate, and liver toxicities and is non-inferior to cTACE in terms of time to progression. • DEB-TACE might be a potential new therapeutic option for HCC patients with TIPS.
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http://dx.doi.org/10.1007/s00330-021-07834-9DOI Listing
April 2021

The efficacy and safety of cupping therapy for treating of intractable peripheral facial paralysis: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Apr;100(16):e25388

Jiangxi University of Traditional Chinese Medicine.

Background: Peripheral facial paralysis (PFP) is a common clinical neurological disease and the incidence of intractable peripheral facial paralysis is on the rise. Symptoms include crooked mouth and eyes, tearing and shallow nasolabial folds. The disease seriously affects the physical and mental health of patients. At present, a large number of clinical studies have shown that cupping is effective in treating intractable peripheral facial paralysis (IPFP). Therefore, the purpose of this review is to evaluate the effectiveness and safety of cupping in the treatment of refractory peripheral facial paralysis.

Methods: We will conduct a comprehensive and systematic search of relevant documents in the following databases: Medline, PubMed, the Cochrane Central Register of Controlled Trials (CENTRAL), Embase, Chinese Biomedical Literatures Database, China National Knowledge Infrastructure (CNKI), Wang Fang Database, Chinese Scientific Journal Database from inception to February 2021 without any language restriction. The 2 reviewers will be independently completed select research, extract data, evaluate research quality and use the Cochrane risk of bias tool to assess methodological quality. Using revman5.4 software for statistical analysis. The degree of heterogeneity will be Determined through heterogeneity test, to definite whether to adopt a random effects model or a fixed-effects model.

Results: The protocol for the meta-analysis will systematically evaluate the efficacy and safety of cupping therapy for intractable peripheral facial paralysis patients.

Conclusion: This study will explore whether or not cupping therapy can be used as one of the non-drug therapies to prevent or treat intractable peripheral facial paralysis.
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http://dx.doi.org/10.1097/MD.0000000000025388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8078480PMC
April 2021

Preparation and evaluation of chitosan-polyvinyl alcohol/polyhexamethylene guanidine hydrochloride antibacterial dressing to accelerate wound healing for infectious skin repair.

Ann Transl Med 2021 Mar;9(6):482

Department of Burn Surgery, the Third Affiliated Hospital of Inner Mongolia Medical University (Inner Mongolia Baogang Hospital), Baotou, China.

Background: Wound infections, especially multidrug-resistant (MDR) bacterial infections, are a major challenge in clinical medicine.

Methods: In this study, a new type of antibacterial sponge was prepared from a solution containing a chitosan-polyvinyl alcohol (CTS-PVA) emulsion with added polyhexamethylene guanidine hydrochloride (PHMG) in a homogeneous medium using lyophilization technology. The antibacterial ability of and CTS-PVA/PHMG sponge against , , , , Methicillin-resistant , multidrug-resistant , and multidrug-resistant in vitro. The structure and physical properties were characterized. The sponge dressing was tested in a -infected full-thickness mouse skin wound defect model. The effects were evaluated by wound area measurement and histological analysis.

Results: The CTS-PVA/PHMG sponge showed broad-spectrum antibacterial ability, including for MDR bacterial stains from clinical sources, while maintaining excellent physicochemical properties, including a high swelling degree and good moisture retention capability. Scanning electron microscopy images displayed the surface morphology of the CTS-PVA/PHMG sponge dressing. The detection of the wound healing rate and histological analysis supported that the new dressing can alleviate the inflammation and accelerate the healing speed of infected wounds and .

Conclusions: CTS-PVA/PHMG sponge shows broad-spectrum antibacterial activity, which can provide a new pathway for clinical prevention and treatment of superbug-infected wounds.
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http://dx.doi.org/10.21037/atm-21-509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8039659PMC
March 2021

Two-minute tidal breathing methacholine bronchial challenge: Comparison of two jet nebulisers.

Clin Respir J 2021 Apr 11. Epub 2021 Apr 11.

Guangzhou Institute of Respiratory Health, State Key Lab of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Background: The American Thoracic Society (ATS) guideline for methacholine challenge testing (MCT) recommended using the English Wright (EW) nebuliser. However, other brands of nebulisers are also indicated to be acceptable for this technique, but further validation of nebuliser performance is recommended.

Objective: To compare the methacholine provocation concentration causing a 20% fall in forced expiratory volume in 1 second (PC -FEV ) measured by using EW nebuliser and DV 646 nebuliser.

Methods: Subjects were randomly assigned to undergo 2-min tidal breathing methacholine challenge with either EW or DV 646 nebuliser on two separate days, which were at least 24 hours but not more than 7 days apart. The above procedure was repeated for each subject in 1 month, but the nebulisers were selected in a reverse order.

Results: The study includes 15 mild and stable asthmatic patients. The geometric means (SD) of methacholine PC measured with using EW and DV 646 nebulisers were 1.82 (6.38) mg/mL versus 0.83 (1.82) mg/mL, respectively in the initial two visits and 2.56 (6.29) mg/mL versus 0.78 (1.40) mg/mL in the following two visits (both P < 0.05). There are well correlations between PC20-EW1 and PC20-EW2 (r = 0.99, P < 0.01), PC20-DV1 and PC20-DV2 (r = 0.88, P < 0.01), and between PC20-EW1 and PC20-DV1 (r = 0.91, P < 0.01), PC20-EW2 and PC20-DV2 (r = 0.78, P < 0.01).

Conclusions: PC -FEV measured by using the two conventional jet nebulisers was both repeatable and the results were highly correlated.
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http://dx.doi.org/10.1111/crj.13374DOI Listing
April 2021

Wearable Tin-Based Perovskite Solar Cells Achieved by a Crystallographic Size Effect.

Angew Chem Int Ed Engl 2021 Jun 17;60(26):14693-14700. Epub 2021 May 17.

Institute of Polymers and Energy Chemistry, Nanchang University, 999 Xuefu Avenue, Nanchang, 330031, China.

Tin-based perovskite solar cells (PSCs) demonstrate a potential application in wearable electronics due to its hypotoxicity. However, poor crystal quality is still the bottleneck for achieving high-performance flexible devices. In this work, graphite phase-C N (g-C N ) is applied into tin-based perovskite as a crystalline template, which delays crystallization via a size-effect and passivates defects simultaneously. The double hydrogen bond between g-C N and formamidine cation can optimize lattice matching and passivation. Moreover, the two-dimensional network structure of g-C N can fit on the crystals, resulting an enhanced hydrophobicity and oxidation resistance. Therefore, the flexible tin-based PSCs with g-C N realize a stabilized power conversion efficiency (PCE) of 8.56 % with negligible hysteresis. In addition, the PSCs can maintain 91 % of the initial PCE after 1000 h under N environment and keep 92 % of their original PCE after 600 cycles at a curvature radius of 3 mm.
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http://dx.doi.org/10.1002/anie.202104201DOI Listing
June 2021

Correction to: Human drug efflux transporter ABCC5 confers acquired resistance to pemetrexed in breast cancer.

Cancer Cell Int 2021 Mar 25;21(1):183. Epub 2021 Mar 25.

Department of Pharmacy, Xin Hua Hospital, Shanghai Jiao Tong University, School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, China.

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http://dx.doi.org/10.1186/s12935-021-01876-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7995568PMC
March 2021
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