Publications by authors named "Hongyang Zhao"

98 Publications

SARS-CoV-2 transmission and control in a hospital setting: an individual-based modelling study.

R Soc Open Sci 2021 Mar 22;8(3):201895. Epub 2021 Mar 22.

Department of Mathematics, Applied Mathematics, and Statistics, Case Western Reserve University, Cleveland, OH 44106, USA.

Development of strategies for mitigating the severity of COVID-19 is now a top public health priority. We sought to assess strategies for mitigating the COVID-19 outbreak in a hospital setting via the use of non-pharmaceutical interventions. We developed an individual-based model for COVID-19 transmission in a hospital setting. We calibrated the model using data of a COVID-19 outbreak in a hospital unit in Wuhan. The calibrated model was used to simulate different intervention scenarios and estimate the impact of different interventions on outbreak size and workday loss. The use of high-efficacy facial masks was shown to be able to reduce infection cases and workday loss by 80% (90% credible interval (CrI): 73.1-85.7%) and 87% (CrI: 80.0-92.5%), respectively. The use of social distancing alone, through reduced contacts between healthcare workers, had a marginal impact on the outbreak. Our results also indicated that a quarantine policy should be coupled with other interventions to achieve its effect. The effectiveness of all these interventions was shown to increase with their early implementation. Our analysis shows that a COVID-19 outbreak in a hospital's non-COVID-19 unit can be controlled or mitigated by the use of existing non-pharmaceutical measures.
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http://dx.doi.org/10.1098/rsos.201895DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8074975PMC
March 2021

Risk factors of SARS-CoV-2 infection in healthcare workers: a retrospective study of a nosocomial outbreak.

Sleep Med X 2020 Dec 14;2:100028. Epub 2020 Oct 14.

Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

Background: Healthcare workers (HCWs) are at the forefront of fighting against the COVID-19 pandemic. However, they are at high risk of acquiring the pathogen from infected patients and transmitting to other HCWs. We aimed to investigate risk factors for nosocomial COVID-19 infection among HCWs in a non-COVID-19 hospital yard.

Methods: Retrospective data collection on demographics, lifestyles, contact status with infected subjects for 118 HCWs (including 12 COVID-19 HCWs) at Union Hospital of Wuhan, China. Sleep quality and working pressure were evaluated by the Pittsburgh Sleep Quality Index (PSQI) and The Nurse Stress Index (NSI), respectively. The follow-up duration was from Dec 25, 2019, to Feb 15, 2020.

Results: A high proportion of COVID-19 HCWs had engaged in night shift-work (75.0% vs. 40.6%) and felt working under pressure (66.7% vs. 32.1%) than uninfected HCWs. SARS-CoV-2 infected HCWs had significantly higher scores of PSQI and NSI than uninfected HCWs ( < 0.001). Specifically, scores of 5 factors (sleep quality, sleep time, sleep efficiency, sleep disorder, and daytime dysfunction) in PSQI were higher among infected HCWs. For NSI, its 5 subscales (nursing profession and work, workload and time allocation, working environment and resources, patient care, management and interpersonal relations) were all higher in infected than uninfected nurse. Furthermore, total scores of PSQI (HR = 2.97, 95%CI = 1.86-4.76;  <0.001) and NSI (HR = 4.67, 95%CI = 1.42-15.45;  = 0.011) were both positively associated with the risk of SARS-CoV-2 infection.

Conclusion: Our analysis shows that poor sleep quality and higher working pressure may increase the risk of nosocomial SARS-CoV-2 infection among HCWs.
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http://dx.doi.org/10.1016/j.sleepx.2020.100028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554494PMC
December 2020

Reconstruction of Craniectomy for Microvascular Decompression with Autologous Particulate Bone.

J Neurol Surg A Cent Eur Neurosurg 2021 Apr 12. Epub 2021 Apr 12.

Department of International Education, Tongji Medical College, Huazhong University of science and Technology, Wuhan, China.

Background And Study Objective:  Cranioplasty after microvascular decompression (MVD) is important for preventing postoperative complications such as headache. Autologous particulate bone is a common material for cranioplasty. The purpose of this study was to evaluate the effect of using autologous particulate bone to reconstruct the cranial defect produced by MVD.

Patients And Methods:  Data were collected from January 2013 to December 2016 from 243 patients who underwent suboccipital retrosigmoidal craniectomy for MVD. The patients were then further divided into two groups: in the first group (from January 2013-October 2015), a cranioplasty was performed using a combination of bone dust (taken from a power drill) and particulate bone (harvested with a rongeur); in the second group (from November 2015-December 2016), the cranial defect was reconstructed using particulate bone alone. Healing of the cranial defect was observed during the follow-up.

Results:  Early postoperative computed tomography (CT), performed during the hospital stay, revealed that the filling of the cranial defects of the first group was better than that of the second group. In addition, surgical-site infections (SSIs) occurred in 13 patients in the first group (9.92%) versus 2 patients in the second group (1.79%). The SSI rate of the first group was significantly higher than that of the second group ( < 0.05). Long-term follow-up CT demonstrated that the average reconstruction rate ((volume of the reconstruction area)/(volume of the cranial defect) × 100%) was 47.88% for the first group and 43.94% for the second group ( > 0.05).

Conclusion:  The use of autologous particulate bone to reconstruct cranial defects after MVD has a good effect and is thus a useful and valuable technique. Bone dust may result in a higher incidence of SSI.
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http://dx.doi.org/10.1055/s-0040-1719138DOI Listing
April 2021

Non-Coding RNAs as Circulating Biomarkers for the Diagnosis of Intracranial Aneurysm: A Systematic Review and Meta-Analysis.

J Stroke Cerebrovasc Dis 2021 Jun 1;30(6):105762. Epub 2021 Apr 1.

Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan 430022, China. Electronic address:

Background: Early diagnosis of intracranial aneurysm (IA) is arduous in the current situation, and no biomarker is available for the screening of IA. We here systematically evaluate the diagnostic value of circulating non-coding RNA (ncRNA) for the diagnosis of IA.

Methods: We searched PubMed, Web of Science, Embase, Scopus and Cochrane Library databases from inception to June 2020. We included studies that investigated the diagnostic performance of circulating ncRNAs for the diagnosis of IA. We performed Random-effect meta-analyses for the diagnostic test accuracy to calculate pooled estimates. Subgroup analyses and sensitivity analyses were conducted to explore the source of heterogeneity.

Results: Thirteen studies, including 1,105 patients and 28 ncRNAs, were included. The pooled sensitivity and specificity were 0.80 (95% confidence interval [CI], 0.76-0.83) and 0.80 (95% CI, 0.76-0.84), respectively, and the area under the hierarchical summary receiver operating characteristic curve was 0.87 (95% CI, 0.84-0.89). The pooled positive and negative likelihood ratios were 3.97 (95% CI, 3.17-4.98) and 0.25 (95% CI, 0.21-0.31), corresponding with a diagnostic odds ratio of 15.63 (95% CI, 10.41-23.47). Subgroup analyses revealed that the diagnostic accuracy of miRNA, lncRNA and circRNA were not significantly different (p > 0.05). Circulating ncRNAs showed higher diagnostic accuracy for patients with unruptured IA than those with ruptured IA (p = 0.0122).

Conclusion: Current evidence suggests that the circulating ncRNA test could be an effective method for universal IA screening. Future clinical studies need to confirm the diagnostic role of specific ncRNAs.
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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2021.105762DOI Listing
June 2021

The MAMs Structure and Its Role in Cell Death.

Cells 2021 Mar 16;10(3). Epub 2021 Mar 16.

China Japan Union Hospital, Jilin University, Changchun 130031, China.

The maintenance of cellular homeostasis involves the participation of multiple organelles. These organelles are associated in space and time, and either cooperate or antagonize each other with regards to cell function. Crosstalk between organelles has become a significant topic in research over recent decades. We believe that signal transduction between organelles, especially the endoplasmic reticulum (ER) and mitochondria, is a factor that can influence the cell fate. As the cellular center for protein folding and modification, the endoplasmic reticulum can influence a range of physiological processes by regulating the quantity and quality of proteins. Mitochondria, as the cellular "energy factory," are also involved in cell death processes. Some researchers regard the ER as the sensor of cellular stress and the mitochondria as an important actuator of the stress response. The scientific community now believe that bidirectional communication between the ER and the mitochondria can influence cell death. Recent studies revealed that the death signals can shuttle between the two organelles. Mitochondria-associated membranes (MAMs) play a vital role in the complex crosstalk between the ER and mitochondria. MAMs are known to play an important role in lipid synthesis, the regulation of Ca homeostasis, the coordination of ER-mitochondrial function, and the transduction of death signals between the ER and the mitochondria. Clarifying the structure and function of MAMs will provide new concepts for studying the pathological mechanisms associated with neurodegenerative diseases, aging, and cancers. Here, we review the recent studies of the structure and function of MAMs and its roles involved in cell death, especially in apoptosis.
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http://dx.doi.org/10.3390/cells10030657DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999768PMC
March 2021

Dither removing Fourier ptychographic microscope based on a two-axis rotation stage.

J Biomed Opt 2021 Mar;26(3)

Ministry of Education, Nankai University, School of Physics, Key Laboratory of Weak-Light Nonlinear, China.

Significance: Large space-bandwidth product is highly desirable in many biomedical imaging. Fourier ptychographic microscopy (FPM) is a computational imaging technique that can significantly increase the space-bandwidth product of a standard microscope. The illuminator of a Fourier ptychographic microscope is not flexible at present, and it is inconvenient to meet different imaging needs.

Aim: An illuminator based on a two-axis motorized rotation stage was presented to provide a more flexible illuminating way with the goal of meeting different imaging needs.

Approach: The illuminator adopts a concentric illuminating method to provide coherent illumination in any direction on the sample plane. The sampling pattern can be freely designed and changed according to the parameters of the imaging system. A dither removing algorithm was proposed to remove the potential dither influence introduced in the image acquisition process.

Results: The illuminator could be conveniently integrated into different imaging systems. The feasibility and flexibility were demonstrated by applying it to imaging systems with numerical aperture of 0.045 and 0.01. The resolution gain is about 4- and 13-fold, respectively. The effectiveness of the dither removing algorithm was validated in both simulation and experiment.

Conclusions: A more flexible illuminator for FPM was presented to meet different imaging needs. A dither removing algorithm was proposed to remove dither influence.
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http://dx.doi.org/10.1117/1.JBO.26.3.036501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7930810PMC
March 2021

A Novel Glucose Metabolism-Related Gene Signature for Overall Survival Prediction in Patients with Glioblastoma.

Biomed Res Int 2021 22;2021:8872977. Epub 2021 Jan 22.

Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

Introduction: Glioblastoma (GBM) is one of the most frequent primary intracranial malignancies, with limited treatment options and poor overall survival rates. Alternated glucose metabolism is a key metabolic feature of tumour cells, including GBM cells. However, due to high cellular heterogeneity, accurately predicting the prognosis of GBM patients using a single biomarker is difficult. Therefore, identifying a novel glucose metabolism-related biomarker signature is important and may contribute to accurate prognosis prediction for GBM patients.

Methods: In this research, we performed gene set enrichment analysis and profiled four glucose metabolism-related gene sets containing 327 genes related to biological processes. Univariate and multivariate Cox regression analyses were specifically completed to identify genes to build a specific risk signature, and we identified ten mRNAs (B4GALT7, CHST12, G6PC2, GALE, IL13RA1, LDHB, SPAG4, STC1, TGFBI, and TPBG) within the Cox proportional hazards regression model for GBM.

Results: Depending on this glucose metabolism-related gene signature, we divided patients into high-risk (with poor outcomes) and low-risk (with satisfactory outcomes) subgroups. The results of the multivariate Cox regression analysis demonstrated that the prognostic potential of this ten-gene signature is independent of clinical variables. Furthermore, we used two other GBM databases (Chinese Glioma Genome Atlas (CGGA) and REMBRANDT) to validate this model. In the functional analysis results, the risk signature was associated with almost every step of cancer progression, such as adhesion, proliferation, angiogenesis, drug resistance, and even an immune-suppressed microenvironment. Moreover, we found that IL31RA expression was significantly different between the high-risk and low-risk subgroups.

Conclusion: The 10 glucose metabolism-related gene risk signatures could serve as an independent prognostic factor for GBM patients and might be valuable for the clinical management of GBM patients. The differential gene IL31RA may be a potential treatment target in GBM.
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http://dx.doi.org/10.1155/2021/8872977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7847336PMC
January 2021

Cerium-doped bimetal organic framework as a superhigh capacity cathode for rechargeable alkaline batteries.

Nanoscale 2021 Feb 5;13(6):3581-3587. Epub 2021 Feb 5.

Tianjin Key Lab for Rare Earth Materials and Applications, Center for Rare Earth and Inorganic Functional Materials, School of Materials Science and Engineering & National Institute for Advanced Materials, Nankai University, Tianjin 300350, China.

In this work, cerium (Ce)-doped NiCo-MOF (metal organic framework) was investigated for its application as a cathode material of alkaline batteries. Inert substitution of Ni/Co by Ce in MOF can make Ce to become part of the backbone of the framework and then ensure structure stability during redox reaction, which greatly improved charge and discharge cycle stability. With dopant mole fraction up to 5%, the redox potential of NiCo-MOF increased by 85%. Adequate Ce doping can potentially enhance rate capacity dramatically due to the large ion radius that provided an extra space for electrolyte ion shutting channel. 1% Ce-doped NiCo-MOF, having a capacity of 286 mA h g at 2 A g and retaining 93% of its capacity (265 mA h g) at 20 A g, emerged as the best performing material among all the Ce-doped NiCo-MOFs presented in this study. A full cell coupling Ce-doped NiCo-MOF cathode and FeO anode was assembled to verify its practical application. The full cell showed an initial capacity of 280 mA h g at 2 A g and retained 92% after 1000 charge and discharge cycles. Therefore, Ce doping emerges as a powerful strategy for the designing of cathode materials used in advanced alkaline battery.
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http://dx.doi.org/10.1039/d0nr08696gDOI Listing
February 2021

Facile Preparation of Tilmicosin-Loaded Polymeric Nanoparticle with Controlled Properties and Functions.

ACS Omega 2020 Dec 7;5(50):32366-32372. Epub 2020 Dec 7.

Shanghai Key Laboratory of Multiphase Materials Chemical Engineering, School of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, People's Republic of China.

As one of the effective broad-spectrum antimicrobial and anti-inflammatory drugs, tilmicosin (TIM) is applied extensively in a wide range of veterinary treatments. However, the low bioavailability typically leads to overuse of TIM in practical applications, which can cause residual accumulation in the environment and contamination of foodstuffs. Here, we report a precipitation method that allows us to prepare TIM-loaded poly(methyl methacrylate--methacrylic acid) (P(MMA--MAA)) nanoparticles. Specifically, TIM and biocompatible P(MMA--MAA) are dissolved in methanol and then water is introduced as an antisolvent, which triggers the co-precipitation and leads to well-controlled nanoparticles. Depending on the drug/polymer mass ratio and the total concentration of drug and polymer, the formed nanoparticles display a tunable radius from 27 to 80 nm with a narrow size distribution, a high drug loading content, and a controlled release of TIM. The encapsulation does not interrupt the antibacterial function of TIM while reducing its cytotoxicity enormously. Moreover, the formed nanoparticles could be dried to powder through freeze-drying, and the redispersion of the particles hardly disturbs the particle size, size distribution, and drug loading content. Our study developed a facile and robust precipitation method for the controlled construction of TIM-loaded polymeric nanoparticles with tunable properties and functions, as well as improved biocompatibility, which shall improve the bioavailability of TIM and enhance the practical applications.
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http://dx.doi.org/10.1021/acsomega.0c04314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758884PMC
December 2020

Hypoxic Glioma Stem Cell-Derived Exosomes Containing Linc01060 Promote Progression of Glioma by Regulating the MZF1/c-Myc/HIF1α Axis.

Cancer Res 2021 01 6;81(1):114-128. Epub 2020 Nov 6.

Department of Neurosurgery, Zhongnan Hospital, Wuhan University, Wuhan, Hubei, China.

Glioma stem cells (GSC) are a subpopulation of tumor cells with special abilities to proliferate and differentiate in gliomas. They are one of the main causes of tumor recurrence, especially under hypoxic conditions. Although long noncoding RNAs (lncRNA) are known to be involved in numerous biological processes and are implied in the occurrence of certain diseases, their role in tumor development and progression remains poorly understood. Here we explored the mechanisms by which lncRNA derived from hypoxic GSCs (H-GSC) cause glioma progression. Isolation and identification of the Linc01060 gene, the exosomes containing them, and the proteins from tumor cells regulating the gene allowed for studying the effects of Linc01060 on proliferation and glycometabolism. H-GSC exerted their effects by transferring exosomes to glioma cells, resulting in a significant increase in Linc01060 levels. Mechanistically, Linc01060 directly interacted with the transcription factor myeloid zinc finger 1 (MZF1) and enhanced its stability. Linc01060 facilitated nuclear translocation of MZF1 and promoted MZF1-mediated c-Myc transcriptional activities. In addition, c-Myc enhanced the accumulation of the hypoxia-inducible factor-1 alpha (HIF1α) at the posttranscriptional level. HIF1α bound the hormone response elements of the Linc01060 promoter, upregulating the transcription of Linc01060 gene. Clinically, Linc01060 was upregulated in glioma and was significantly correlated with tumor grade and poor clinical prognosis. Overall, these data show that secretion of Linc01060-containing exosomes from H-GSCs activates prooncogenic signaling pathways in glioma cells to promote disease progression. SIGNIFICANCE: These findings suggest that inhibition of Linc01060-containing exosomes or targeting the Linc01060/MZF1/c-Myc/HIF1α axis may be an effective therapeutic strategy in glioma.
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http://dx.doi.org/10.1158/0008-5472.CAN-20-2270DOI Listing
January 2021

Efficacy of unilateral hemilaminectomy for intraspinal tumor resection: a systematic review and meta-analysis.

Ann Palliat Med 2021 Feb 15;10(2):984-999. Epub 2020 Sep 15.

Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background: To evaluate, via a meta-analysis, the clinical effect of unilateral hemilaminectomy for intraspinal tumor removal.

Methods: PubMed, Springer, Wanfang Data, CBM, CNKI, and other databases were searched for relevant randomized controlled trials (RCT), in Chinese and other languages, that involved comparisons of unilateral hemilaminectomy with other techniques for intraspinal tumor removal.

Results: Thirteen RCTs were finally included, with a total of 1,424 patients. Unilateral hemilaminectomy for intraspinal tumor removal was found to reduce the amount of intraoperative hemorrhage (Z =45.67, P<0.00001), operative time (Z =55.35, P<0.00001), length of hospital stay (Z =111.67, P<0.00001), and inbed time (Z =142.08, P<0.00001) of patients. Compared with the traditional operative methods, unilateral hemilaminectomy for intraspinal tumor removal can improve the cure rate of patients [odds ratio (OR) =3.84; 95% confidence interval (CI), 2.1-7.01; Z =4.38; P<0.001) and reduce the incidence of spinal deformities (OR =0.11; 95% CI, 0.04-0.34; Z =3.83; P=0.001). It does not increase the risks of postoperative cerebrospinal fluid leak (OR =0.63; 95% CI, 0.21-1.88; Z =0.82; P=0.41), postoperative infection (OR =0.74; 95% CI, 0.31-1.77; Z =0.67; P=0.50), pain (OR =0.29; 95% CI, 0.07-1.18; Z =1.73; P=0.08), myasthenia (OR =-0.04; 95% CI, -0.07 to 0.01; Z =2.29; P=0.02), and other complications.

Conclusions: Unilateral hemilaminectomy for the microsurgical removal of intraspinal tumors has the advantages of minimal operative trauma, fast recovery, and better postoperative stability of the vertebral column.
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http://dx.doi.org/10.21037/apm-20-499DOI Listing
February 2021

Changes in the Gut Microbiota of Children with Autism Spectrum Disorder.

Autism Res 2020 09 24;13(9):1614-1625. Epub 2020 Aug 24.

NHC Key Laboratory of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), School of Basic Medical Sciences, Fudan University, Shanghai, China.

Alterations in the gut microbiota may influence gastrointestinal (GI) dysbiosis frequently reported in individuals with autism spectrum disorder (ASD). In this study, we sequenced the bacterial 16S rRNA gene to evaluate changes in fecal microbiota between 48 children with ASD and 48 healthy children in China. At the phylum level, the number of Firmicutes, Proteobacteria, and Verrucomicrobia decreased in children with ASD, while the Bacteroidetes/Firmicutes was significantly higher in autistic children due to enrichment of Bacteroidetes. At the genus level, the amount of Bacteroides, Prevotella, Lachnospiracea_incertae_sedis, and Megamonas increased, while Clostridium XlVa, Eisenbergiella, Clostridium IV, Flavonifractor, Escherichia/Shigella, Haemophilus, Akkermansia, and Dialister decreased in children with ASD relative to the controls. Significant increase was observed in the number of species synthesizing branched-chain amino acids (BCAAs), like Bacteroides vulgatus and Prevotella copri, while the numbers of Bacteroides fragilis and Akkermansia muciniphila decreased in children with ASD compared to the controls. Most importantly, the highest levels of pathogenic bacteria were different for each child with ASD in this cohort. We found that only one functional module, cellular antigens, was enriched in children with ASD, and other pathways like lysine degradation and tryptophan metabolism were significantly decreased in children with ASD. These findings provide further evidence of altered gut microbiota in Chinese ASD children and may contribute to the treatment of patients with ASD. LAY SUMMARY: This study characterized the gut bacteria composition of 48 children with ASD and 48 neurotypical children in China. The metabolic disruptions caused by altered gut microbiota may contribute significantly to the neurological pathophysiology of ASD, including significant increases in the number of species synthesizing BCAAs, and decreases in the number of probiotic species. These findings suggest that a gut microbiome-associated therapeutic intervention may provide a novel strategy for treating GI symptoms frequently seen in individuals with ASD. Autism Res 2020, 13: 1614-1625. © 2020 International Society for Autism Research, Wiley Periodicals, Inc.
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http://dx.doi.org/10.1002/aur.2358DOI Listing
September 2020

PINK1: The guard of mitochondria.

Life Sci 2020 Oct 14;259:118247. Epub 2020 Aug 14.

China-Japan Union Hospital, Jilin University, China. Electronic address:

PTEN-induced putative kinase 1 (PINK1) performs many important functions in cells and has been highlighted for its role in early-onset Parkinson's disease. In recent years, an increasing number of studies have revealed the involvement of PINK1 in regulation of a variety of cell physiological and pathophysiological processes, of which regulation of mitochondrial function remains the most prominent. As the "energy factory" of cells, mitochondria provide energy support for various cellular activities. Changes in mitochondrial function often have a fundamental and global impact on cellular activities. Moreover, mitochondrial dysfunction has been implicated in many diseases, especially those related to aging. Thus, a comprehensive study of PINK1 will help us better understand the various cell physiological and pathophysiological processes in which PINK1 is involved, including a variety of mitochondria-related diseases such as Parkinson's disease. This article will review the structural characteristics and expression regulation of PINK1, as well as its unique role in mitochondrial quality control (MQC) systems.
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http://dx.doi.org/10.1016/j.lfs.2020.118247DOI Listing
October 2020

Using arterial-venous analysis to characterize cancer metabolic consumption in patients.

Nat Commun 2020 06 23;11(1):3169. Epub 2020 Jun 23.

Chinese Institute for Brain Research, Beijing, 102206, Beijing, China.

Understanding tumor metabolism holds the promise of new insights into cancer biology, diagnosis and treatment. To assess human cancer metabolism, here we report a method to collect intra-operative samples of blood from an artery directly upstream and a vein directly downstream of a brain tumor, as well as samples from dorsal pedal veins of the same patients. After performing targeted metabolomic analysis, we characterize the metabolites consumed and produced by gliomas in vivo by comparing the arterial supply and venous drainage. N-acetylornithine, D-glucose, putrescine, and L-acetylcarnitine are consumed in relatively large amounts by gliomas. Conversely, L-glutamine, agmatine, and uridine 5-monophosphate are produced in relatively large amounts by gliomas. Further we verify that D-2-hydroxyglutarate (D-2HG) is high in venous plasma from patients with isocitrate dehydrogenases1 (IDH1) mutations. Through these paired comparisons, we can exclude the interpatient variation that is present in plasma samples usually taken from the cubital vein.
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http://dx.doi.org/10.1038/s41467-020-16810-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311411PMC
June 2020

Clinical manifestations and evidence of neurological involvement in 2019 novel coronavirus SARS-CoV-2: a systematic review and meta-analysis.

J Neurol 2020 Oct 11;267(10):2777-2789. Epub 2020 Jun 11.

Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277, Jiefang Avenue, Wuhan, 430022, Hubei Province, China.

Background: Coronavirus disease 2019 (COVID-19) has become a global pandemic, affecting millions of people. However, clinical research on its neurological manifestations is thus far limited. In this study, we aimed to systematically collect and investigate the clinical manifestations and evidence of neurological involvement in COVID-19.

Methods: Three medical (Medline, Embase, and Scopus) and two preprints (BioRxiv and MedRxiv) databases were systematically searched for all published articles on neurological involvement in COVID-19 since the outbreak. All included studies were systematically reviewed, and selected clinical data were collected for meta-analysis via random-effects.

Results: A total of 41 articles were eligible and included in this review, showing a wide spectrum of neurological manifestations in COVID-19. The meta-analysis for unspecific neurological symptoms revealed that the most common manifestations were fatigue (33.2% [23.1-43.3]), anorexia (30.0% [23.2-36.9]), dyspnea/shortness of breath (26.9% [19.2-34.6]), and malaise (26.7% [13.3-40.1]). The common specific neurological symptoms included olfactory (35.7-85.6%) and gustatory (33.3-88.8%) disorders, especially in mild cases. Guillain-Barré syndrome and acute inflammation of the brain, spinal cord, and meninges were repeatedly reported after COVID-19. Laboratory, electrophysiological, radiological, and pathological evidence supported neurologic involvement of COVID-19.

Conclusions: Neurological manifestations are various and prevalent in COVID-19. Emerging clinical evidence suggests neurological involvement is an important aspect of the disease. The underlying mechanisms can include both direct invasion and maladaptive inflammatory responses. More studies should be conducted to explore the role of neurological manifestations in COVID-19 progression and to verify their underlying mechanisms.
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http://dx.doi.org/10.1007/s00415-020-09974-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288253PMC
October 2020

Hypoxic Cancer-Secreted Exosomal miR-182-5p Promotes Glioblastoma Angiogenesis by Targeting Kruppel-like Factor 2 and 4.

Mol Cancer Res 2020 08 4;18(8):1218-1231. Epub 2020 May 4.

Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China.

Glioblastoma (GBM) is the most lethal primary brain tumor and has a complex molecular profile. Hypoxia plays a critical role during tumor progression and in the tumor microenvironment (TME). Exosomes released by tumor cells contain informative nucleic acids, proteins, and lipids involved in the interaction between cancer and stromal cells, thus leading to TME remodeling. Accumulating evidence indicates that exosomes play a pivotal role in cell-to-cell communication. However, the mechanism by which hypoxia affects tumor angiogenesis via exosomes derived from tumor cells remains largely unknown. In our study, we found that, compared with the parental cells under normoxic conditions, the GBM cells produced more exosomes, and miR-182-5p was significantly upregulated in the exosomes from GBM cells under hypoxic conditions. Exosomal miR-182-5p directly suppressed its targets Kruppel-like factor 2 and 4, leading to the accumulation of VEGFR, thus promoting tumor angiogenesis. Furthermore, exosome-mediated miR-182-5p also inhibited tight junction-related proteins (such as ZO-1, occludin, and claudin-5), thus enhancing vascular permeability and tumor transendothelial migration. Knockdown of miR-182-5p reduced angiogenesis and tumor proliferation. Interestingly, we found elevated levels circulating miR-182-5p in patient blood serum and cerebrospinal fluid samples, and its expression level was inversely related to the prognosis. IMPLICATIONS: Overall, our data clarify the diagnostic and prognostic value of tumor-derived exosome-mediated miR-182-5p and reveal the distinctive cross-talk between tumor cells and human umbilical vein endothelial cells mediated by tumor-derived exosomes that modulate tumor vasculature.
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http://dx.doi.org/10.1158/1541-7786.MCR-19-0725DOI Listing
August 2020

A COVID-19 Patient Who Underwent Endonasal Endoscopic Pituitary Adenoma Resection: A Case Report.

Neurosurgery 2020 08;87(2):E140-E146

Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background And Importance: A pituitary adenoma patient who underwent surgery in our department was diagnosed with COVID-19 and 14 medical staff were confirmed infected later. This case has been cited several times but without accuracy or entirety, we feel obligated to report it and share our thoughts on the epidemic among medical staff and performing endonasal endoscopic surgery during COVID-19 pandemic.

Clinical Presentation: The patient developed a fever 3 d post endonasal endoscopic surgery during which cerebrospinal leak occurred, and was confirmed with SARS-CoV-2 infection later. Several medical staff outside the operating room were diagnosed with COVID-19, while the ones who participated in the surgery were not.

Conclusion: The deceptive nature of COVID-19 results from its most frequent onset symptom, fever, a cliché in neurosurgery, which makes it hard for surgeons to differentiate. The COVID-19 epidemic among medical staff in our department was deemed as postoperative rather than intraoperative transmission, and attributed to not applying sufficient personal airway protection. Proper personal protective equipment and social distancing between medical staff contributed to limiting epidemic since the initial outbreak. Emergency endonasal endoscopic surgeries are feasible since COVID-19 is still supposed to be containable when the surgeries are performed in negative pressure operating rooms with personal protective equipment and the patients are kept under quarantine postoperatively. However, we do not encourage elective surgeries during this pandemic, which might put patients in conditions vulnerable to COVID-19.
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http://dx.doi.org/10.1093/neuros/nyaa147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188148PMC
August 2020

In Reply: Precautions for Endoscopic Transnasal Skull Base Surgery During the COVID-19 Pandemic.

Neurosurgery 2020 08;87(2):E160-E161

Department of Neurosurgery Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan, China.

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http://dx.doi.org/10.1093/neuros/nyaa145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188152PMC
August 2020

A Combinatorial Approach with Cerebellar Tonsil Suspension to Treating Symptomatic Chiari Malformation Type I in Adults: A Retrospective Study.

World Neurosurg 2020 11 12;143:e19-e35. Epub 2020 Mar 12.

Departments of Physical Medicine and Rehabilitation and Neurosurgery, Harvard Medical School, Boston, Massachusetts, USA.

Background: Primary Chiari malformations (CMs) are congenital defects of the skull base and brain. Among the 4 CM types, type I (CM-I) occurs most frequently and may cause somatosensorimotor, autonomic and vision symptoms. Presently, posterior fossa decompression alone (PFD) or with duraplasty (PFDD) and cerebellar tonsil (CbT) shrinkage tactics are standard treatments, albeit inherent issues. There has been no report on devising CbT suspension (CTS) to manage CM-I.

Objectives: 1) To design a CTS protocol that can be used with CbT coagulation (CTC) and PFDD; 2) to evaluate the regimen for feasibility, safety, and efficacy in a retrospective study; and 3) to obtain data for planning prospective studies to validate PFDD + CTC + CTS as a novel approach to treating adult CM-I.

Methods: PFDD + CTC + CTS (n = 17), PFDD + CTC (n = 13), and PFDD (n = 12) were performed for 42 adult patients (age range, 18-55 years; female:male = 27:15) following a balanced study design. Neck Disability Index (NDI), Chicago Chiari Outcome Scale (CCOS), and /magnetic resonance imaging/computed tomography were used to determine postsurgery outcomes for approximately 20 months.

Results: Comparing to PFDD + CTC or PFDD, patients receiving PFDD + CTC +CTS operation exhibited significantly improved group average NDI (10.72 ± 3.95%; P = 0.007), CbT elevation distance (7.06 ± 2.42 mm; P < 0.001, Kruskal-Wallis test; 55.7 ± 25.4% higher than the presurgery level; P < 0.001, analysis of variance), and syringomyelia syrinx retraction (P = 0.009, analysis of variance).

Conclusions: The PFDD + CTC + CTS regimen appeared to be safe and potentially more efficacious in patients with CM-I evaluated for the period, relative to PFDD + CTC or PFDD treatment. Future prospective studies were warranted.
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http://dx.doi.org/10.1016/j.wneu.2020.02.184DOI Listing
November 2020

Optimization design of a novel X-type six-high rolling mill based on maximum roll system stiffness.

PLoS One 2020 19;15(2):e0228593. Epub 2020 Feb 19.

School of Materials and Metallurgy, University of Science and Technology Liaoning, Anshan, China.

The present investigation devices a novel X-type six-high (X-6h) mill. In addition, parametric models of different roll layouts such as the four-high (4-h), I-type six-high (I-6h), and X-6h mills are established. Three-dimensional (3D) finite element (FE) contact analysis for a strip rolling process is conducted when the mills are subjected to a constant vertical load of 65 kN. Through comparative analysis of von Mises stress, contact stress and elastic deformation displacement in three roll layouts, the rigidity characteristic of each is obtained, and it is found that the proposed X-6h mill has the largest roll gap stiffness. The influence of different roll diameter ratios on the roll gap stiffness of the roll system is investigated, based on which an optimization design model is built. Further, by taking into account the roll gap stiffness of the roll system as the optimization objective, the optimum diameter ratios of backup roll (BUR) to work roll (WR) of the X-6h rolling mill is achieved via the genetic algorithm (GA) optimization method, obtaining the optimum structural parameters of BUR and WR as well. The reliability of the proposed design is verified by manufacturing a prototype mill which produced magnesium alloy and aluminum alloy strips of high quality.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0228593PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029872PMC
April 2020

van der Waals force layered multiferroic hybrid perovskite (CHNH)CuCl single crystals.

Phys Chem Chem Phys 2020 Feb 11;22(7):4235-4239. Epub 2020 Feb 11.

Hubei Key Laboratory of Plasma Chemistry and Advanced Materials, Wuhan Institute of Technology, No. 206 Guanggu 1st Road, Wuhan 430205, China.

In inorganic-organic perovskites, the three-dimensional arrangement of the organic group results in more subtle balance of charge, spin and space, thereby providing an attractive route toward new multiferroics. Here we report the existing of multiple ferroic orderings in inorganic-organic layered perovskites with relative strong hydrogen bond ordering of the organic chains intra plane. In addition, the inter plane in perovskite is stacking via van der Waals force. However, such magnetoelectric coupling properties for this compound have not been reported since it is difficult to characterize the properties in single crystals since most of the hybrid perovskites are usually deliquescent and unstable when exposed to air. To deal with these problems, we synthesized a (CHNH)CuCl single crystal by using a simple evaporation technique, and demonstrated ferroelectric, magnetic and magneto-electric properties of (CHNH)CuCl. The internal hydrogen bonding of easily tunable organic unit combined with 3d transition-metal layers in such hybrid perovskites make (CHNH)CuCl a multiferroic crystal with magnetoelectrical coupling and offer an new way to engineer multifunctional multiferroic.
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http://dx.doi.org/10.1039/c9cp05976hDOI Listing
February 2020

Construction of high quality ultrathin lanthanide oxyiodide nanosheets for enhanced CT imaging and anticancer drug delivery to efficient cancer theranostics.

Biomaterials 2020 02 5;230:119670. Epub 2019 Dec 5.

School of Materials Science and Engineering, National Institute for Advanced Materials, Tianjin Key Lab for Rare Earth Materials and Applications, Center for Rare Earth and Inorganic Functional Materials, Nankai University, Tianjin, 300350, China; Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Rare Earth Materials Chemistry and Applications, PKU-HKU Joint Laboratory in Rare Earth Materials and Bioinorganic Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China; College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, China.

Two-dimensional (2D) ultrathin nanomaterials have shown extensive attention and potential biomedical applications in cancer theranostics. Herein, for the first time, we report the synthesis of monodisperse ultrathin lanthanum oxyiodide (LaOI) nanosheets with a thickness of merely 3 nm based on a facile wet chemistry strategy. By tuning the solvent composition and molar ratios of the precursors, we can modulate the shape and thickness of the nanosheets. Furthermore, a series of ultrathin lanthanide oxyiodides are synthesized by this method with tunable morphology. LaOI nanosheets as drug delivery platform showed ultrahigh anticancer doxorubicin (DOX) loading capacity (300 wt%) and pH-responsive release behaviour, as well as excellent cellular biocompatibility and efficiently intracellular nucleus delivery of DOX. LaOI with low dose DOX demonstrate enhanced cancer cell killing ability in vitro compared with DOX. The intravenous melanoma model shows that LaOI with low dose (1 mg mL) could significantly inhibit the tumor growth without side toxicity, relative to pure DOX. In addition, LaOI nanosheets also act as high resolution contrast agent for enhanced X-ray computed tomography imaging relative to the commercial iohexol. In summary, the LaOI nanosheets could serve as a competitive safe and low dose drug delivery platform for highly efficiently cancer imaging and therapy.
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http://dx.doi.org/10.1016/j.biomaterials.2019.119670DOI Listing
February 2020

ELTD1 facilitates glioma proliferation, migration and invasion by activating JAK/STAT3/HIF-1α signaling axis.

Sci Rep 2019 09 25;9(1):13904. Epub 2019 Sep 25.

Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Street, Wuhan, 430022, P.R. China.

The upregulation of ELTD1 ([epidermal growth factor (EGF), latrophilin and seven transmembrane domain-containing 1] on chromosome 1) in tumor cells has been reported in several types of cancer and correlates with poor cancer prognosis. However, the role of ELTD1 in glioma progression remains unknown. In this study, we examined ELTD1 expression levels in human glioma cell lines and in sixteen human gliomas of different grades. The molecular effects of ELTD1 in glioma cells were measured using quantitative polymerase chain reaction (qRT-PCR), Western blotting, Cell proliferation assays, Matrigel migration and invasion assays and brain orthotopic xenografts. We found that high expression levels of ELTD1 were positively associated with cancer progression and poor prognosis in human glioma. Mechanistically, ELTD1 activated the JAK/STAT3/HIF-1α signaling axis and p-STAT3 bound with HIF-1α. Taken together, our data provide a plausible mechanism for ELTD1-modulated glioma progression and suggest that ELTD1 may represent a potential therapeutic target in the prevention and therapy of glioma.
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http://dx.doi.org/10.1038/s41598-019-50375-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761139PMC
September 2019

Accuracy of magnetic resonance imaging texture analysis in differentiating low-grade from high-grade gliomas: systematic review and meta-analysis.

BMJ Open 2019 09 5;9(9):e027144. Epub 2019 Sep 5.

Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Objectives: Texture analysis (TA) is a method used for quantifying the spatial distributions of intensities in images using scanning software. MRI TA could be applied to grade gliomas. This meta-analysis was performed for assessing the accuracy of MRI TA in differentiating low-grade gliomas from high-grade ones.

Methods: PubMed, Cochrane Library, Science Direct and Embase were searched for identifying suitable studies from their inception to 1 September 2018. The quality of the studies was evaluated on the basis of the Quality Assessment of Diagnostic Accuracy Studies guidelines. We estimated the pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR) and diagnostic OR (DOR) using the summary receiver operating characteristic (SROC) for identifying the accuracy of MRI TA in grading gliomas. Fagan nomogram was applied for assessing the clinical utility of TA.

Results: Six studies including 440 patients were included and analysed. The pooled sensitivity, specificity, PLR, NLR and DOR with 95% CIs were 0.93 (95% CI 0.88 to 0.96), 0.86 (95% CI 0.81 to 0.89), 6.4 (95% CI 4.8 to 8.6), 0.08 (95% CI 0.05 to 0.15) and 78 (95% CI 39 to 156), respectively. The SROC curve showed an area under the curve of 0.96 (95% CI 0.93 to 0.97). Deeks test confirmed no significant publication bias in all studies. Fagan nomogram revealed that the post-test probability increased by 43% in patients with positive pre-test.

Conclusions: The findings of this meta-analysis suggested that MRI TA has high accuracy in differentiating low-grade gliomas from high-grade ones. A standardised methodology is warranted to guide the use of this technique for clinical decision-making.
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http://dx.doi.org/10.1136/bmjopen-2018-027144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731805PMC
September 2019

Protein kinase C-ε contributes to a chronic inhibitory effect of IL-1β on voltage-gated sodium channels in mice with febrile seizure.

J Integr Neurosci 2019 06;18(2):173-179

Department of Pediatrics, Jinan Central Hospital Affiliated to Shandong University, Jinan City, Shandong Province, 250013, P. R. China.

This study aimed to understand the role of Interleukin-1β in mouse febrile seizures. To investigate the chronic effects of raised Interleukin-1β on seizures, the sodium currents of hippocampal neurons were recorded by whole-cell voltage clamp. Interleukin-1β inhibited sodium currents in mouse hippocampal neurons and verified that protein kinase C epsilon contributed to the effect of Interleukin-1β exposure. The inhibitory effect was also identified in neurons from a protein kinase C epsilon null mutant mouse. Action potentials were recorded using a ramp depolarizing current. Peak spike depolarization was significantly reduced by Interleukin-1β treatment, and was abolished following the administration of a protein kinase C epsilon inhibitor, εV1-2. However, neither Interleukin-1β nor εV1-2 had any significant effect on spike threshold. Interleukin-1β reduced the amplitude of action potentials due to its inhibitory effect on sodium channels. This is hypothesised to decrease the release of presynaptic transmitters of neuroexcitability, thus exerting a neuroprotective role in excitotoxicity. To ascertain the role of protein kinase C epsilon on febrile seizures in vivo, a heated water-bath model was used to identify susceptible mice. It was found that protein kinase C epsilon reduced susceptibility to, and frequency of, febrile seizure onset. This may be related to the neuroprotective effect of Interleukin-1β on hippocampal neurons.
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http://dx.doi.org/10.31083/j.jin.2019.02.145DOI Listing
June 2019

Oxygen Vacancies on Layered Niobic Acid That Weaken the Catalytic Conversion of Polysulfides in Lithium-Sulfur Batteries.

Angew Chem Int Ed Engl 2019 Aug 10;58(33):11491-11496. Epub 2019 Jul 10.

School of Materials Science and Engineering & National Institute for Advanced Materials, Key Laboratory of Advanced Energy Materials Chemistry, Tianjin Key Lab for Rare Earth Materials and Applications, Centre for Rare Earth and Inorganic Functional Materials, Nankai University, Tianjin, 300350, China.

Oxygen vacancies are usually considered to be beneficial in catalytic conversion of polysulfides in lithium-sulfur batteries. Now it is demonstrated that the conversion of polysulfides was hindered by oxygen vacancies on ultrathin niobic acid. The inferior performance induced by the oxygen vacancy was mainly attributed to the decreased electric conductivity as well as the weakened adsorption of polysulfides on the catalyst surface. This work shows that the care should be taken when designing a new catalyst for the lithium-sulfur battery using a defect-engineering strategy.
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http://dx.doi.org/10.1002/anie.201905852DOI Listing
August 2019

Human epididymis protein 4 (HE4) protects against cystic pulmonary fibrosis associated-inflammation through inhibition of NF-κB and MAPK singnaling.

Genes Genomics 2019 09 4;41(9):1045-1053. Epub 2019 Jun 4.

Department of Neonatal, The Second Affiliated Hospital of Xi'an Medical College, No. 167, Textile City East Street, Baqiao District, Xi'an, 710038, Shanxi, China.

Background: Cystic pulmonary fibrosis (CF) affects mostly the lung of the newborns. Chronic infection and inflammation become the major causes of morbidity and mortality in CF. However, the underlying molecular mechanisms causing CF still remain unclear.

Methods: ELISA assay was used to examine the expression of HE4 and pro-inflammatory cytokines in W126VA4 cells supernatant fluid. qRT-PCR was applicable to determine the mRNA level of HE4, α-SMA, collagen 1, MMP2, MMP9 and various interleukins. Immunofluorescent assay was used to test the expression of HE4 in WI-26 VA4 cells. Major elements of MAPK and NF-κB signals pathways were examined by western blot.

Results: We found higher expression of HE4 in CF patients serum and lung biopsy. Interestingly, HE4 expression was positively correlated with fibrosis markers expression. In addition,HE4 overexpression increased inflammatory cytokines secretion and fibrosis markers expression in WI-26 VA4 cells. And NF-κB pathways were responsible for elevated inflammation. In addition, HE4/MAPK/MMPs signaling cascades destroyed the normal extracellular matrix (ECM) and promoted fibrosis.

Conclusions: Overall, we first identified that HE4 promoted CF-associated inflammation. Additionally, NF-κB and MAPK signalings were further validated to be responsible for CF-associated inflammation and ECM destruction. Characterization of lumacaftor/ivacaftor in CF-associated inflammation may provide a novel insight into clinical CF treatment.
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http://dx.doi.org/10.1007/s13258-019-00836-4DOI Listing
September 2019

Integrated analysis of 34 microarray datasets reveals CBX3 as a diagnostic and prognostic biomarker in glioblastoma.

J Transl Med 2019 05 28;17(1):179. Epub 2019 May 28.

Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Background: Glioblastomas have a high degree of malignancy, high recurrence rate, high mortality rate, and low cure rate. Searching for new markers of glioblastomas is of great significance for improving the diagnosis, prognosis and treatment of glioma.

Methods: Using the GEO public database, we combined 34 glioma microarray datasets containing 1893 glioma samples and conducted genetic data mining through statistical analysis, bioclustering, and pathway analysis. The results were validated in TCGA, CGGA, and internal cohorts. We further selected a gene for subsequent experiments and conducted cell proliferation and cell cycle analyses to verify the biological function of this gene.

Results: Eight glioblastoma-specific differentially expressed genes were screened using GEO. In the TCGA and CGGA cohorts, patients with high CBX3, BARD1, EGFR, or IFRD1 expression had significantly shorter survival but patients with high GUCY1A3 or MOBP expression had significantly longer survival than patients with lower expression of these genes. After reviewing the literature, we selected the CBX3 gene for further experiments. We confirmed that CBX3 was overexpressed in glioblastoma by immunohistochemical analysis of tissue microarrays and qPCR analysis of surgical specimens. The functional assay results showed that silencing CBX3 arrests the cell cycle in the G2/M phase, thereby weakening the cell proliferation ability.

Conclusions: We used a multidisciplinary approach to analyze glioblastoma samples in 34 microarray datasets, revealing novel diagnostic and prognostic biomarkers in patients with glioblastoma and providing a new direction for screening tumor markers.
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http://dx.doi.org/10.1186/s12967-019-1930-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540543PMC
May 2019

Electrochromic Poly(chalcogenoviologen)s as Anode Materials for High-Performance Organic Radical Lithium-Ion Batteries.

Angew Chem Int Ed Engl 2019 Jun 16;58(25):8468-8473. Epub 2019 May 16.

Frontier Institute of Science and Technology, State Key Laboratory for Strength and Vibration of Mechanical Structures, Xi'an Key Laboratory of Sustainable Energy Materials Chemistry, Xi'an Jiaotong University, Xi'an, Shaanxi Province, 710054, China.

A series of electrochromic electron-accepting poly(chalcogenoviologen)s with multiple, stable, and reversible redox centers were used as anodic materials in organic radical lithium-ion batteries (ORLIBs). The introduction of heavy atoms (S, Se, and Te) into the viologen scaffold significantly improved the capacity and cycling stability of the ORLIBs. Notably, the poly(Te-BnV) anode was able to intercalate 20 Li ions and showed higher conductivity and insolubility in the electrolyte, thus contributing to a reversible capacity of 502 mAh g at 100 mA g when the Coulombic efficiency approached 100 %. The charged/discharged state of flexible electrochromic batteries fabricated from these anodic materials could be monitored visually owing to the unique electrochromic and redox properties of the materials. This study opens a promising avenue for the development of organic polymer-based electrodes for flexible hybrid visual electronics.
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http://dx.doi.org/10.1002/anie.201903152DOI Listing
June 2019

Can Systemic Inflammatory Markers Be Used to Predict the Pathological Grade of Meningioma Before Surgery?

World Neurosurg 2019 Jul 1;127:e677-e684. Epub 2019 Apr 1.

Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address:

Background: We sought to determine whether systemic inflammatory markers (SIMs) can be used to predict the pathological grade of meningioma before surgery.

Methods: Patients with histopathologically proven intracranial meningiomas who had undergone surgery from January 2014 to April 2018 were identified. The 14 most recent SIM levels measured before surgery were retrieved. The Mann-Whitney U test was used to determine the statistically significant differences between groups. Receiver operating characteristic curves were constructed, and the areas under the curve (AUC) were calculated to assess the diagnostic value of each biomarker. Predictive models built with biomarker pairs using logistic regression or support vector machine classifiers were used to assess their combined performance.

Results: A total of 672 patients with 575 and 97 low-grade and high-grade meningiomas, respectively, were investigated. Of the 14 SIMS, 7 differed significantly between the 2 meningioma groups. However, receiver operating characteristic analysis showed that none of these 7 SIMs alone could predict for the meningioma grade; the highest AUC was 0.61. Two biomarkers (erythrocyte and neutrophil/lymphocyte ratio) were incorporated into the logistic regression model; the corresponding AUC was 0.64. Moreover, 21 biomarker pairs were used to train the support vector machine classifiers; the AUCs of 6 pairs were >0.55; the maximum AUC was 0.60.

Conclusions: SIMs obtained from routine preoperative laboratory testing had a limited ability to differentiate low- and high-grade meningioma in our cohort of 672 patients. Further prospective, multicenter studies with larger sample sizes are warranted to confirm this finding.
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http://dx.doi.org/10.1016/j.wneu.2019.03.241DOI Listing
July 2019