Hongxin Deng

Hongxin Deng

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Hongxin Deng

Publications by authors named "Hongxin Deng"

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SARI suppresses colitis-associated cancer development by maintaining MCP-1-mediated tumour-associated macrophage recruitment.

J Cell Mol Med 2019 Oct 2. Epub 2019 Oct 2.

State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, China.

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http://dx.doi.org/10.1111/jcmm.14699DOI Listing
October 2019

SARI attenuates colon inflammation by promoting STAT1 degradation in intestinal epithelial cells.

Mucosal Immunol 2019 Sep 10;12(5):1130-1140. Epub 2019 Jun 10.

State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan Province, China.

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http://dx.doi.org/10.1038/s41385-019-0178-9DOI Listing
September 2019

Temporal expression and functional analysis of long non-coding RNAs in colorectal cancer initiation.

J Cell Mol Med 2019 Jun 28;23(6):4127-4138. Epub 2019 Mar 28.

State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, P. R. China.

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http://dx.doi.org/10.1111/jcmm.14300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533480PMC
June 2019

Interleukin-35 in immune-related diseases: protection or destruction.

Immunology 2019 05 7;157(1):13-20. Epub 2019 Mar 7.

Department of Medicine, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://dx.doi.org/10.1111/imm.13044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459776PMC
May 2019

Targeted demethylation of the SARI promotor impairs colon tumour growth.

Cancer Lett 2019 Apr 14;448:132-143. Epub 2019 Feb 14.

State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan, 610041, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2019.01.040DOI Listing
April 2019

Modulating the Tumor Microenvironment via Oncolytic Viruses and CSF-1R Inhibition Synergistically Enhances Anti-PD-1 Immunotherapy.

Mol Ther 2019 01 17;27(1):244-260. Epub 2018 Nov 17.

State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, China. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2018.11.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319306PMC
January 2019

Follistatin-like protein 5 inhibits hepatocellular carcinoma progression by inducing caspase-dependent apoptosis and regulating Bcl-2 family proteins.

J Cell Mol Med 2018 12 25;22(12):6190-6201. Epub 2018 Sep 25.

State Key Laboratory of Biotherapy and Cancer Center/Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

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http://dx.doi.org/10.1111/jcmm.13906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237577PMC
December 2018

Conversion of human adipose-derived stem cells into functional and expandable endothelial-like cells for cell-based therapies.

Stem Cell Res Ther 2018 12 17;9(1):350. Epub 2018 Dec 17.

State Key Laboratory of Biotherapy and Cancer Center/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Ke-yuan Road 4, No. 1, Gao-peng Street, Chengdu, 610041, Sichuan, People's Republic of China.

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https://stemcellres.biomedcentral.com/articles/10.1186/s1328
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http://dx.doi.org/10.1186/s13287-018-1088-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296081PMC
December 2018

Enrichment and characterization of cancer stem-like cells in ultra-low concentration of serum and non-adhesive culture system.

Am J Transl Res 2018 15;10(5):1552-1561. Epub 2018 May 15.

Institute of Immunology and Molecular Medicine, Jining Medical University Jining 272067, Shandong, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992539PMC
May 2018

IL-35 recombinant protein reverses inflammatory bowel disease and psoriasis through regulation of inflammatory cytokines and immune cells.

J Cell Mol Med 2018 02 29;22(2):1014-1025. Epub 2017 Nov 29.

State Key Laboratory of Biotherapy and Cancer Center/Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.

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http://doi.wiley.com/10.1111/jcmm.13428
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http://dx.doi.org/10.1111/jcmm.13428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783847PMC
February 2018

Recent Advances in Therapeutic Genome Editing in China.

Hum Gene Ther 2018 02;29(2):136-145

1 State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center , Chengdu, China.

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http://dx.doi.org/10.1089/hum.2017.210DOI Listing
February 2018

DDA1, a novel oncogene, promotes lung cancer progression through regulation of cell cycle.

J Cell Mol Med 2017 08 17;21(8):1532-1544. Epub 2017 Feb 17.

State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

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http://dx.doi.org/10.1111/jcmm.13084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542901PMC
August 2017

A novel bispecific molecule delivered by recombinant AAV2 suppresses ocular inflammation and choroidal neovascularization.

J Cell Mol Med 2017 08 22;21(8):1555-1571. Epub 2017 Mar 22.

Department of Ophthalmology, College of Medicine, University of Florida, Gainesville, FL, USA.

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http://dx.doi.org/10.1111/jcmm.13086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543459PMC
August 2017

A novel cancer vaccine with the ability to simultaneously produce anti-PD-1 antibody and GM-CSF in cancer cells and enhance Th1-biased antitumor immunity.

Signal Transduct Target Ther 2016 18;1:16025. Epub 2016 Nov 18.

State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

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http://www.nature.com/articles/sigtrans201625
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http://dx.doi.org/10.1038/sigtrans.2016.25DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661645PMC
November 2016

Translational Medicine Center of West China Hospital.

Sci China Life Sci 2016 Oct;59(10):1055-1056

West China Hospital of Sichuan University, Chengdu, 610041, China.

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http://dx.doi.org/10.1007/s11427-015-4863-yDOI Listing
October 2016

IL-35 Decelerates the Inflammatory Process by Regulating Inflammatory Cytokine Secretion and M1/M2 Macrophage Ratio in Psoriasis.

J Immunol 2016 09 15;197(6):2131-44. Epub 2016 Aug 15.

State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China;

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http://dx.doi.org/10.4049/jimmunol.1600446DOI Listing
September 2016

Rapid generation of functional hepatocyte-like cells from human adipose-derived stem cells.

Stem Cell Res Ther 2016 08 5;7(1):105. Epub 2016 Aug 5.

State Key Laboratory of Biotherapy and Cancer Center/Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Ke-yuan Road 4, No. 1, Gao-peng Street, Chengdu, Sichuan, 610041, People's Republic of China.

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http://dx.doi.org/10.1186/s13287-016-0364-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974756PMC
August 2016

Functional Nanoparticles Activate a Decellularized Liver Scaffold for Blood Detoxification.

Small 2016 Apr 23;12(15):2067-76. Epub 2016 Feb 23.

State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, 610041, China.

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http://dx.doi.org/10.1002/smll.201503320DOI Listing
April 2016

Establishment and characterization of intraperitoneal xenograft models by co-injection of human tumor cells and extracellular matrix gel.

Oncol Lett 2015 Dec 29;10(6):3450-3456. Epub 2015 Sep 29.

Research Centre for Public Health and Preventive Medicine, West China School of Public Health, No. 4 West China Teaching Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China; State Key Laboratory of Biotherapy and Cancer Center, Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China.

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http://dx.doi.org/10.3892/ol.2015.3764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4665880PMC
December 2015

Inhibition of A20 expression in tumor microenvironment exerts anti-tumor effect through inducing myeloid-derived suppressor cells apoptosis.

Sci Rep 2015 Nov 12;5:16437. Epub 2015 Nov 12.

Division of Nephrology of Department of Internal Medicine and Lab of Aging Research, State Key Laboratory of Biotherapy &Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China.

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http://dx.doi.org/10.1038/srep16437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642332PMC
November 2015

Rapid and high-efficiency generation of mature functional hepatocyte-like cells from adipose-derived stem cells by a three-step protocol.

Stem Cell Res Ther 2015 Oct 5;6:193. Epub 2015 Oct 5.

State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, No.17, section3, Renmin South Road, Chengdu, 610041, P.R. China.

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http://dx.doi.org/10.1186/s13287-015-0181-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595267PMC
October 2015

Anti-TNF-α monoclonal antibody reverses psoriasis through dual inhibition of inflammation and angiogenesis.

Int Immunopharmacol 2015 Sep 7;28(1):731-43. Epub 2015 Aug 7.

State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.intimp.2015.07.036DOI Listing
September 2015

Polyclonal rabbit anti-human ovarian cancer globulins inhibit tumor growth through apoptosis involving the caspase signaling.

Sci Rep 2014 May 15;4:4984. Epub 2014 May 15.

State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, China.

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http://dx.doi.org/10.1038/srep04984DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021334PMC
May 2014

IL-37 ameliorates the inflammatory process in psoriasis by suppressing proinflammatory cytokine production.

J Immunol 2014 Feb 22;192(4):1815-23. Epub 2014 Jan 22.

State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, People's Republic of China;

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http://dx.doi.org/10.4049/jimmunol.1300047DOI Listing
February 2014

Antitumor effects obtained by autologous Lewis lung cancer cell vaccine engineered to secrete mouse interleukin 27 by means of cationic liposome.

Mol Immunol 2013 Oct 21;55(3-4):264-74. Epub 2013 Mar 21.

State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, People's Republic of China.

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http://dx.doi.org/10.1016/j.molimm.2013.02.006DOI Listing
October 2013

Efficient inhibition of intraperitoneal ovarian cancer growth in nude mice by liposomal delivery of short hairpin RNA against STAT3.

J Obstet Gynaecol Res 2013 Mar 25;39(3):701-9. Epub 2012 Sep 25.

State Key Laboratory of Biotherapy, West China Hospital, Sichuan, China.

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http://dx.doi.org/10.1111/j.1447-0756.2012.02007.xDOI Listing
March 2013

The enhanced antitumor effects of biodegradable cationic heparin-polyethyleneimine nanogels delivering HSulf-1 gene combined with cisplatin on ovarian cancer.

Int J Oncol 2012 Oct 18;41(4):1504-12. Epub 2012 Jul 18.

Department of Gynecology and Obstetrics, Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second Hospital, State Key Laboratory of Biotherapy and Cancer Center, Sichuan University, Chengdu 610041, Sichuan, P.R. China.

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http://dx.doi.org/10.3892/ijo.2012.1558DOI Listing
October 2012

Therapeutic upregulation of Class A scavenger receptor member 5 inhibits tumor growth and metastasis.

Cancer Sci 2012 Sep 17;103(9):1631-9. Epub 2012 Aug 17.

State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.

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http://dx.doi.org/10.1111/j.1349-7006.2012.02350.xDOI Listing
September 2012

Efficient inhibition of ovarian cancer by recombinant CXC chemokine ligand 10 delivered by novel biodegradable cationic heparin-polyethyleneimine nanogels.

Oncol Rep 2012 Aug 6;28(2):668-76. Epub 2012 Jun 6.

Department of Gynecology and Obstetrics, Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second Hospital, State Key Laboratory of Biotherapy and Cancer Center, Sichuan University, Chengdu 610041, Sichuan, PR China.

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http://dx.doi.org/10.3892/or.2012.1853DOI Listing
August 2012

Enhancement of cisplatin sensitivity in lung cancer xenografts by liposome-mediated delivery of the plasmid expressing small hairpin RNA targeting Survivin.

J Biomed Nanotechnol 2012 Aug;8(4):633-41

State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, Chengdu, 610041, China.

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http://dx.doi.org/10.1166/jbn.2012.1419DOI Listing
August 2012

Soluble vascular endothelial growth factor decoy receptor FP3 exerts potent antiangiogenic effects.

Mol Ther 2012 May 24;20(5):938-47. Epub 2012 Jan 24.

State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.

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http://dx.doi.org/10.1038/mt.2011.285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3345977PMC
May 2012

Efficient inhibition of an intraperitoneal xenograft model of human ovarian cancer by HSulf-1 gene delivered by biodegradable cationic heparin-polyethyleneimine nanogels.

Oncol Rep 2012 Feb 11;27(2):363-70. Epub 2011 Nov 11.

Department of Gynecology and Obstetrics, Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second Hospital, Sichuan University, Chengdu 610041, Sichuan, PR China.

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http://dx.doi.org/10.3892/or.2011.1550DOI Listing
February 2012

Efficient inhibition of ovarian cancer by truncation mutant of FILIP1L gene delivered by novel biodegradable cationic heparin-polyethyleneimine nanogels.

Hum Gene Ther 2011 Nov 8;22(11):1413-22. Epub 2011 Jun 8.

Gynecological Oncology of Biotherapy Laboratory, Department of Gynecology and Obstetrics, West China Second Hospital, Sichuan University, Chengdu 610041, People's Republic of China.

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http://dx.doi.org/10.1089/hum.2011.047DOI Listing
November 2011

Intravenous liposomal delivery of the short hairpin RNAs against Plk1 controls the growth of established human hepatocellular carcinoma.

Cancer Biol Ther 2011 Feb 15;11(4):401-9. Epub 2011 Feb 15.

State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Sichuan, China.

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http://dx.doi.org/10.4161/cbt.11.4.14178DOI Listing
February 2011

A vector-based short hairpin RNA targeting Aurora A inhibits breast cancer growth.

Int J Oncol 2010 May;36(5):1121-8

State Key Laboratory of Biotherapy, West China Hospital and West China Medical School, Sichuan University, Sichuan, 610041, P.R. China.

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May 2010

VEGF-targeted short hairpin RNA inhibits intraperitoneal ovarian cancer growth in nude mice.

Oncology 2009 2;77(6):385-94. Epub 2010 Feb 2.

Department of Gynecology and Obstetrics, West China Second Hospital, Chengdu, PR China.

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http://dx.doi.org/10.1159/000279385DOI Listing
March 2010

Prokaryotic expression, purification and characterization of a novel pro-apoptosis protein hPNAS-4.

Biotechnol Appl Biochem 2010 Feb 11;55(2):63-72. Epub 2010 Feb 11.

State Key Laboratory of Biotherapy, West China Hospital and College of Life Science, Sichuan University, Chengdu 610041, People's Republic of China.

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http://dx.doi.org/10.1042/BA20090111DOI Listing
February 2010

Targeting CD24 for treatment of ovarian cancer by short hairpin RNA.

Cytotherapy 2009 ;11(5):642-52

Department of Gynecology and Obstetrics, West China Second Hospital, Chengdu, People's Republic of China.

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http://dx.doi.org/10.1080/14653240902878308DOI Listing
November 2009

Improved therapeutic efficacy against murine carcinoma by combining honokiol with gene therapy of PNAS-4, a novel pro-apoptotic gene.

Cancer Sci 2009 Sep 4;100(9):1757-66. Epub 2009 Jun 4.

State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, China.

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http://dx.doi.org/10.1111/j.1349-7006.2009.01242.xDOI Listing
September 2009

A novel strategy for tumour therapy combining cell apoptosis and active immunity induced by caspy2, a zebrafish caspase.

J Cell Mol Med 2009 Aug 9;13(8B):2271-81. Epub 2009 Feb 9.

State Key Laboratory of Biotherapy, West China Hospital and College of Life Science, Sichuan University, Chengdu, Sichuan, The People's Republic of China.

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http://dx.doi.org/10.1111/j.1582-4934.2009.00693.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529962PMC
August 2009

A novel poly(epsilon-caprolactone)-pluronic-poly(epsilon-caprolactone) grafted polyethyleneimine(PCFC-g-PEI), Part 1, synthesis, cytotoxicity, and in vitro transfection study.

BMC Biotechnol 2009 Jul 17;9:65. Epub 2009 Jul 17.

State Key Lab of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, PR China.

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http://dx.doi.org/10.1186/1472-6750-9-65DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2717081PMC
July 2009

Characterization of a novel rat gene RTAP2a, screened by cross-reactive SEREX, restrictedly expressed in testis.

J Biosci Bioeng 2009 Jun;107(6):589-95

Department of Thoracic Oncology of Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, No.1 Keyuan Road 4th, Chengdu, Sichuan, 610041, P.R. China.

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http://dx.doi.org/10.1016/j.jbiosc.2009.02.005DOI Listing
June 2009

Genetic transfer of PNAS-4 induces apoptosis and enhances sensitivity to gemcitabine in lung cancer.

Cell Biol Int 2009 Mar 11;33(3):276-82. Epub 2008 Dec 11.

West China Hospital, Sichuan University, Chengdu, PR China.

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http://dx.doi.org/10.1016/j.cellbi.2008.11.014DOI Listing
March 2009

Immunotherapy of hepatocellular carcinoma with a vaccine based on xenogeneic homologous alpha fetoprotein in mice.

Biochem Biophys Res Commun 2008 Nov 24;376(1):10-4. Epub 2008 Aug 24.

State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Gao Xin Qu Ke Yuan 4th Road No. 1, Chengdu, Sichuan, People's Republic of China.

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http://dx.doi.org/10.1016/j.bbrc.2008.08.061DOI Listing
November 2008

Efficient inhibition of ovarian cancer growth and prolonged survival by transfection with a novel pro-apoptotic gene, hPNAS-4, in a mouse model. In vivo and in vitro results.

Oncology 2008 29;75(3-4):137-44. Epub 2008 Sep 29.

Department of Gynecology and Obstetrics, West China Second Hospital, Sichuan University, Chengdu, PR China.

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http://dx.doi.org/10.1159/000158664DOI Listing
November 2008

A novel injectable local hydrophobic drug delivery system: Biodegradable nanoparticles in thermo-sensitive hydrogel.

Int J Pharm 2008 Jul 25;359(1-2):228-33. Epub 2008 Mar 25.

State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China.

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http://dx.doi.org/10.1016/j.ijpharm.2008.03.023DOI Listing
July 2008

Expression of human Biot2 and its potential function on carcinogenesis in endometrial cancer.

Acta Obstet Gynecol Scand 2007 ;86(12):1503-9

Department of Pathology, West China Second Hospital of SiChuan University, Chengdu, People's Republic of China.

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http://dx.doi.org/10.1080/00016340701736946DOI Listing
December 2007

Synthesis, characterization and hydrolytic degradation study of polyetheresteramide copolymers based on epsilon-caprolactone, 6-aminocaproic acid, and poly(ethylene glycol).

J Mater Sci Mater Med 2007 Oct 12;18(10):2085-91. Epub 2007 Jun 12.

State Key Laborotary of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.

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http://dx.doi.org/10.1007/s10856-007-3096-4DOI Listing
October 2007

[Prokaryotic expression, purification, refolding and biological assays of recombinant human interleukin 4 inclusion body].

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 2007 Aug;24(4):866-9

State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.

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August 2007

A critical role of vascular endothelial growth factor D in zebrafish embryonic vasculogenesis and angiogenesis.

Biochem Biophys Res Commun 2007 Jun 17;357(4):924-30. Epub 2007 Apr 17.

State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, and School of Life Science, Sichuan University, Chengdu 610041, China.

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http://dx.doi.org/10.1016/j.bbrc.2007.04.033DOI Listing
June 2007

A novel pro-apoptosis protein PNAS-4 from Xenopus laevis: cloning, expression, purification, and polyclonal antibody production.

Biochemistry (Mosc) 2007 Jun;72(6):664-71

College of Life Science, Sichuan University, Chengdu, Sichuan 610041, P. R. China.

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http://dx.doi.org/10.1134/s0006297907060107DOI Listing
June 2007