Publications by authors named "Hongjun Song"

100Publications

Robust Hi-C Maps of Enhancer-Promoter Interactions Reveal the Function of Non-coding Genome in Neural Development and Diseases.

Mol Cell 2020 08 26;79(3):521-534.e15. Epub 2020 Jun 26.

Department of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA; Department of Computer and Data Sciences, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molcel.2020.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415676PMC
August 2020

Using Two- and Three-Dimensional Human iPSC Culture Systems to Model Psychiatric Disorders.

Adv Neurobiol 2020 ;25:237-257

Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-3-030-45493-7_9DOI Listing
January 2020

Modeling neurological disorders using brain organoids.

Semin Cell Dev Biol 2020 Jun 16. Epub 2020 Jun 16.

Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA; Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semcdb.2020.05.026DOI Listing
June 2020

Sliced Human Cortical Organoids for Modeling Distinct Cortical Layer Formation.

Cell Stem Cell 2020 May 5;26(5):766-781.e9. Epub 2020 Mar 5.

Department of Neuroscience and Mahoney Institute for Neurosciences, University of Pennsylvania, Philadelphia, PA 19104, USA; Neuroscience Graduate Program, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.stem.2020.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366517PMC
May 2020

Nr4a1 suppresses cocaine-induced behavior via epigenetic regulation of homeostatic target genes.

Nat Commun 2020 01 24;11(1):504. Epub 2020 Jan 24.

Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-020-14331-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981219PMC
January 2020

Optimization of Weighting Window Functions for SAR Imaging via QCQP Approach.

Sensors (Basel) 2020 Jan 11;20(2). Epub 2020 Jan 11.

Department of Space Microwave Remote Sensing System, Institute of Electronics, Chinese Academy of Sciences, Beijing 100190, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/s20020419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013442PMC
January 2020

A Patient-Derived Glioblastoma Organoid Model and Biobank Recapitulates Inter- and Intra-tumoral Heterogeneity.

Cell 2020 01 26;180(1):188-204.e22. Epub 2019 Dec 26.

Department of Neuroscience and Mahoney Institute for Neurosciences, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Glioblastoma Translational Center of Excellence, The Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2019.11.036DOI Listing
January 2020

Adult neurogenesis and the dentate gyrus: Predicting function from form.

Behav Brain Res 2020 02 10;379:112346. Epub 2019 Nov 10.

Department of Neuroscience, University of Pennsylvania, Philadelphia, PA, 19104, USA; Mahoney Institute for Neurosciences, University of Pennsylvania, Philadelphia, PA, 19104, USA; Department of Developmental and Cell Biology, University of Pennsylvania, Philadelphia, PA, 19104, USA; Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA; Institute for Epigenetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbr.2019.112346DOI Listing
February 2020

Dentate Gyrus Mossy Cells Share a Role in Pattern Separation with Dentate Granule Cells and Proximal CA3 Pyramidal Cells.

J Neurosci 2019 11 22;39(48):9570-9584. Epub 2019 Oct 22.

Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, Maryland 21218,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.0940-19.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880467PMC
November 2019

Transplantation of Human Brain Organoids: Revisiting the Science and Ethics of Brain Chimeras.

Cell Stem Cell 2019 Oct;25(4):462-472

Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA; Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; The Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.stem.2019.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180006PMC
October 2019

Evaluating Neurodevelopmental Consequences of Perinatal Exposure to Antiretroviral Drugs: Current Challenges and New Approaches.

J Neuroimmune Pharmacol 2019 Sep 11. Epub 2019 Sep 11.

Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11481-019-09880-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064402PMC
September 2019

Structural interaction between DISC1 and ATF4 underlying transcriptional and synaptic dysregulation in an iPSC model of mental disorders.

Mol Psychiatry 2019 Aug 23. Epub 2019 Aug 23.

Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41380-019-0485-2DOI Listing
August 2019

Interplay between a Mental Disorder Risk Gene and Developmental Polarity Switch of GABA Action Leads to Excitation-Inhibition Imbalance.

Cell Rep 2019 08;28(6):1419-1428.e3

Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S22111247193092
Publisher Site
http://dx.doi.org/10.1016/j.celrep.2019.07.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690484PMC
August 2019

FMRP Modulates Neural Differentiation through mA-Dependent mRNA Nuclear Export.

Cell Rep 2019 07;28(4):845-854.e5

Departments of Pediatrics, Neurology, and Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL 60611, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2019.06.072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687293PMC
July 2019

Pathophysiology and Mechanisms of Zika Virus Infection in the Nervous System.

Annu Rev Neurosci 2019 07;42:249-269

Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA; email:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1146/annurev-neuro-080317-062231DOI Listing
July 2019

Loss of chromatin modulator Dpy30 compromises proliferation and differentiation of postnatal neural stem cells.

J Mol Cell Biol 2019 May 24. Epub 2019 May 24.

Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jmcb/mjz041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052988PMC
May 2019

Brain organoids: advances, applications and challenges.

Development 2019 04 16;146(8). Epub 2019 Apr 16.

Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

View Article

Download full-text PDF

Source
http://dev.biologists.org/lookup/doi/10.1242/dev.166074
Publisher Site
http://dx.doi.org/10.1242/dev.166074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503989PMC
April 2019

Can pretreatment F-FDG PET tumor texture features predict the outcomes of osteosarcoma treated by neoadjuvant chemotherapy?

Eur Radiol 2019 Jul 11;29(7):3945-3954. Epub 2019 Mar 11.

Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai, 200233, People's Republic of China.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00330-019-06074-2
Publisher Site
http://dx.doi.org/10.1007/s00330-019-06074-2DOI Listing
July 2019

Nanoparticle technology and stem cell therapy team up against neurodegenerative disorders.

Adv Drug Deliv Rev 2019 08 21;148:239-251. Epub 2019 Feb 21.

Department of Neuroscience and Mahoney Institute for Neurosciences, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA; The Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; The Epigenetics Institute, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.addr.2019.02.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6703981PMC
August 2019

Autocrine Mfge8 Signaling Prevents Developmental Exhaustion of the Adult Neural Stem Cell Pool.

Cell Stem Cell 2018 09 30;23(3):444-452.e4. Epub 2018 Aug 30.

Department of Neuroscience, Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; The Biochemistry, Cellular and Molecular Biology Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; The Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.stem.2018.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128767PMC
September 2018

Fragile X mental retardation protein modulates the stability of its m6A-marked messenger RNA targets.

Hum Mol Genet 2018 11;27(22):3936-3950

Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/hmg/ddy292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6216232PMC
November 2018

Applications of Human Brain Organoids to Clinical Problems.

Dev Dyn 2019 01 2;248(1):53-64. Epub 2018 Oct 2.

Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/dvdy.24662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312736PMC
January 2019

Epitranscriptomes in the Adult Mammalian Brain: Dynamic Changes Regulate Behavior.

Neuron 2018 07;99(2):243-245

Department of Neuroscience and Mahoney Institute for Neurosciences, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; The Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuron.2018.07.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778836PMC
July 2018

In vivo clonal analysis reveals spatiotemporal regulation of thalamic nucleogenesis.

PLoS Biol 2018 04 23;16(4):e2005211. Epub 2018 Apr 23.

Department of Neuroscience, University of Minnesota Medical School, Minneapolis, Minnesota, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pbio.2005211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933804PMC
April 2018

Epigenetics and epitranscriptomics in temporal patterning of cortical neural progenitor competence.

J Cell Biol 2018 06 17;217(6):1901-1914. Epub 2018 Apr 17.

Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1083/jcb.201802117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987727PMC
June 2018

Coupling Neurogenesis to Circuit Formation.

Cell 2018 04;173(2):288-290

Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Regenerative Medicine, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; The Epigenetics Institute, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2018.03.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190801PMC
April 2018

Radial glial cells in the adult dentate gyrus: what are they and where do they come from?

F1000Res 2018 5;7:277. Epub 2018 Mar 5.

Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12688/f1000research.12684.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840617PMC
March 2018

A previously undetected pathology of Zika virus infection.

Nat Med 2018 03;24(3):258-259

Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nm.4510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190581PMC
March 2018

Generation of human brain region-specific organoids using a miniaturized spinning bioreactor.

Nat Protoc 2018 03 22;13(3):565-580. Epub 2018 Feb 22.

Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nprot.2017.152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241211PMC
March 2018

Synaptic dysfunction in complex psychiatric disorders: from genetics to mechanisms.

Genome Med 2018 01 31;10(1). Epub 2018 Jan 31.

Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

View Article

Download full-text PDF

Source
https://genomemedicine.biomedcentral.com/articles/10.1186/s1
Publisher Site
http://dx.doi.org/10.1186/s13073-018-0518-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793422PMC
January 2018

Epitranscriptomic mA Regulation of Axon Regeneration in the Adult Mammalian Nervous System.

Neuron 2018 01;97(2):313-325.e6

Department of Neuroscience, Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Biochemistry, Cellular, and Molecular Biology Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Cellular and Molecular Medicine Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuron.2017.12.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777326PMC
January 2018

Stem cells take the stairs.

J Biol Chem 2017 12;292(48):19605-19606

From The Graduate Program of Biochemistry, Cellular, and Molecular Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 and

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.H117.796383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5712602PMC
December 2017

Multiplexed Biomarker Panels Discriminate Zika and Dengue Virus Infection in Humans.

Mol Cell Proteomics 2018 02 15;17(2):349-356. Epub 2017 Nov 15.

From the ‡Department of Pharmacology & Molecular Sciences; Johns Hopkins School of Medicine, Baltimore, Maryland 21205;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/mcp.RA117.000310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795396PMC
February 2018

DISC1 Regulates Neurogenesis via Modulating Kinetochore Attachment of Ndel1/Nde1 during Mitosis.

Neuron 2017 Dec 2;96(5):1041-1054.e5. Epub 2017 Nov 2.

Division of Life Science, State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China; Center of Systems Biology and Human Health, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuron.2017.10.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731645PMC
December 2017

Temporal Control of Mammalian Cortical Neurogenesis by mA Methylation.

Cell 2017 Nov 28;171(4):877-889.e17. Epub 2017 Sep 28.

Department of Neuroscience and Mahoney Institute for Neurosciences, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; The Pre-doctoral Human Genetic Training Program, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; The Biochemistry, Cellular, and Molecular Biology Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; The Cellular and Molecular Medicine Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; The Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; The Epigenetics Institute, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00928674173105
Publisher Site
http://dx.doi.org/10.1016/j.cell.2017.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679435PMC
November 2017

Zika-Virus-Encoded NS2A Disrupts Mammalian Cortical Neurogenesis by Degrading Adherens Junction Proteins.

Cell Stem Cell 2017 09 17;21(3):349-358.e6. Epub 2017 Aug 17.

Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; The Bioengineering Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Graduate Program in Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; The Biochemistry, Cellular and Molecular Biology Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neuroscience, Mahoney Institute for Neurosciences, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Regenerative Medicine, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.stem.2017.07.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600197PMC
September 2017

Racing to Uncover the Link between Zika Virus and Microcephaly.

Cell Stem Cell 2017 06;20(6):749-753

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.stem.2017.05.010DOI Listing
June 2017

How does Zika virus cause microcephaly?

Genes Dev 2017 05;31(9):849-861

Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/gad.298216.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458753PMC
May 2017

Disrupted-in-Schizophrenia-1 (DISC1) protein disturbs neural function in multiple disease-risk pathways.

Hum Mol Genet 2017 07;26(14):2634-2648

Tsinghua-Peking Center for Life Sciences, IDG/McGovern Institute for Brain Research, MOE Key Laboratory of Protein Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, P.R. China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/hmg/ddx147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886174PMC
July 2017

An Intrinsic Epigenetic Barrier for Functional Axon Regeneration.

Neuron 2017 Apr;94(2):337-346.e6

Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Graduate Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neuroscience, Mahoney Institute for Neurosciences, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuron.2017.03.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007997PMC
April 2017

Using brain organoids to understand Zika virus-induced microcephaly.

Development 2017 03;144(6):952-957

Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/dev.140707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358105PMC
March 2017

Neuronal activity modifies the chromatin accessibility landscape in the adult brain.

Nat Neurosci 2017 Mar 6;20(3):476-483. Epub 2017 Feb 6.

Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nn.4494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325677PMC
March 2017

Spatial Representations of Granule Cells and Mossy Cells of the Dentate Gyrus.

Neuron 2017 Feb 26;93(3):677-690.e5. Epub 2017 Jan 26.

Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD 21218, USA; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore MD 21205 USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuron.2016.12.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5300955PMC
February 2017

Advances in Zika Virus Research: Stem Cell Models, Challenges, and Opportunities.

Cell Stem Cell 2016 12;19(6):690-702

Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

View Article

Download full-text PDF

Source
http://www.cell.com/cell-stem-cell/pdf/S1934-5909(16)30415-5
Web Search
http://dx.doi.org/10.1016/j.stem.2016.11.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5218815PMC
December 2016

The Role of Epigenetic Mechanisms in the Regulation of Gene Expression in the Nervous System.

J Neurosci 2016 11;36(45):11427-11434

Picower Institute for Learning and Memory and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139

View Article

Download full-text PDF

Source
http://www.jneurosci.org/content/jneuro/36/45/11427.full.pdf
Web Search
http://dx.doi.org/10.1523/JNEUROSCI.2492-16.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125210PMC
November 2016

Epigenetic regulation of axonal regenerative capacity.

Epigenomics 2016 10 19;8(10):1429-1442. Epub 2016 Sep 19.

Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/epi-2016-0058DOI Listing
October 2016

Persistent Structural Plasticity Optimizes Sensory Information Processing in the Olfactory Bulb.

Neuron 2016 07 30;91(2):384-96. Epub 2016 Jun 30.

Laboratory for Perception and Memory, Pasteur Institute, 75015 Paris, France; Centre National de la Recherche Scientifique (CNRS), Unité de Recherche Associée (UMR3571), 75015 Paris, France. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuron.2016.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476833PMC
July 2016

Epigenetic mechanisms in neurogenesis.

Nat Rev Neurosci 2016 09 23;17(9):537-49. Epub 2016 Jun 23.

Institute for Cell Engineering, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, Maryland 21205, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrn.2016.70DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610421PMC
September 2016

Neural stem cells attacked by Zika virus.

Cell Res 2016 07 10;26(7):753-4. Epub 2016 Jun 10.

Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/cr.2016.68DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129882PMC
July 2016

Brain-specific Crmp2 deletion leads to neuronal development deficits and behavioural impairments in mice.

Nat Commun 2016 06 1;7. Epub 2016 Jun 1.

State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms11773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895353PMC
June 2016

Neuronal Circuitry Mechanisms Regulating Adult Mammalian Neurogenesis.

Cold Spring Harb Perspect Biol 2016 08 1;8(8). Epub 2016 Aug 1.

Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 Adrienne Helis Malvin Medical Research Foundation, New Orleans, Louisiana 70130-2685.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/cshperspect.a018937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968157PMC
August 2016

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure.

Cell 2016 May 22;165(5):1238-1254. Epub 2016 Apr 22.

Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Graduate Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; The Solomon Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

View Article

Download full-text PDF

Source
http://www.cell.com/cell/pdf/S0092-8674(16)30467-6.pdf
Web Search
http://www.cell.com/cms/attachment/2054161004/2060541246/mmc
Web Search
http://dx.doi.org/10.1016/j.cell.2016.04.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900885PMC
May 2016

Patient iPSCs: a new discovery tool for Smith-Lemli-Opitz syndrome.

Nat Med 2016 Apr;22(4):343-4

Institute for Cell Engineering and the Department of Neurology at the Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nm.4081DOI Listing
April 2016

Diversity of Neural Precursors in the Adult Mammalian Brain.

Cold Spring Harb Perspect Biol 2016 Apr 1;8(4):a018838. Epub 2016 Apr 1.

Institute for Cell Engineering, The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 Department of Neurology, The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 Adrienne Helis Malvin Medical Research Foundation, New Orleans, Louisiana 70130-2685 Human Genetics Predoctoral Program, The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/cshperspect.a018838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817799PMC
April 2016

The TLX-miR-219 cascade regulates neural stem cell proliferation in neurodevelopment and schizophrenia iPSC model.

Nat Commun 2016 Mar 11;7:10965. Epub 2016 Mar 11.

Division of Stem Cell Biology Research, Department of Developmental and Stem Cell Biology, Cancer Center, Beckman Research Institute of City of Hope, 1500 E. Duarte Road, Duarte, California 91010, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms10965DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4793043PMC
March 2016

Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth.

Cell Stem Cell 2016 05 4;18(5):587-90. Epub 2016 Mar 4.

Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21025, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21025, USA; Cellular and Molecular Medicine Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD 21025, USA; Solomon Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21025, USA; Kavli Neuroscience Discovery Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21025, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21025, USA. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S19345909160010
Publisher Site
http://dx.doi.org/10.1016/j.stem.2016.02.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5299540PMC
May 2016

Adult Neurogenesis and Psychiatric Disorders.

Cold Spring Harb Perspect Biol 2016 Sep 1;8(9). Epub 2016 Sep 1.

Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 Graduate Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/cshperspect.a019026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008067PMC
September 2016

Heterogeneity of Radial Glia-Like Cells in the Adult Hippocampus.

Stem Cells 2016 Apr 4;34(4):997-1010. Epub 2016 Jan 4.

Department of Fundamental Neuroscience, University of Lausanne, rue du Bugnon, Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/stem.2266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340291PMC
April 2016

Lin28A Binds Active Promoters and Recruits Tet1 to Regulate Gene Expression.

Mol Cell 2016 Jan 17;61(1):153-60. Epub 2015 Dec 17.

Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; The Cellular and Molecular Medicine Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; The Solomon Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

View Article

Download full-text PDF

Source
http://www.cell.com/molecular-cell/pdf/S1097-2765(15)00934-X
Web Search
http://linkinghub.elsevier.com/retrieve/pii/S109727651500934
Publisher Site
http://dx.doi.org/10.1016/j.molcel.2015.11.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779955PMC
January 2016

Modeling psychiatric disorders with patient-derived iPSCs.

Curr Opin Neurobiol 2016 Feb 17;36:118-27. Epub 2015 Dec 17.

Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.conb.2015.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4738077PMC
February 2016

Modeling synaptogenesis in schizophrenia and autism using human iPSC derived neurons.

Mol Cell Neurosci 2016 06 2;73:52-62. Epub 2015 Dec 2.

Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; The Solomon Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mcn.2015.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535231PMC
June 2016

Latent tri-lineage potential of adult hippocampal neural stem cells revealed by Nf1 inactivation.

Nat Neurosci 2015 Dec 2;18(12):1722-4. Epub 2015 Nov 2.

Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nn.4159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661096PMC
December 2015

Adult Mammalian Neural Stem Cells and Neurogenesis: Five Decades Later.

Cell Stem Cell 2015 Oct;17(4):385-95

Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; The Solomon Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.stem.2015.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683085PMC
October 2015

Neurogenesis in the Adult Hippocampus.

Cold Spring Harb Perspect Biol 2015 Sep 1;7(9):a018812. Epub 2015 Sep 1.

Laboratory of Genetics LOG-G, The Salk Institute for Biological Studies, La Jolla, California 92037.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/cshperspect.a018812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4563705PMC
September 2015

Single-Cell RNA-Seq with Waterfall Reveals Molecular Cascades underlying Adult Neurogenesis.

Cell Stem Cell 2015 Sep 20;17(3):360-72. Epub 2015 Aug 20.

Graduate Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; The Solomon Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.stem.2015.07.013DOI Listing
September 2015

DNA damage and repair regulate neuronal gene expression.

Cell Res 2015 Sep 17;25(9):993-4. Epub 2015 Jul 17.

Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/cr.2015.85DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559811PMC
September 2015

Tangential migration of neuronal precursors of glutamatergic neurons in the adult mammalian brain.

Proc Natl Acad Sci U S A 2015 Jul 13;112(30):9484-9. Epub 2015 Jul 13.

Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Biochemistry, Cellular and Molecular Biology Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Cellular and Molecular Medicine Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1508545112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522763PMC
July 2015

DISC1-mediated dysregulation of adult hippocampal neurogenesis in rats.

Front Syst Neurosci 2015 25;9:93. Epub 2015 Jun 25.

Institute for Cell Engineering, Johns Hopkins University School of Medicine Baltimore, MD, USA ; Department of Neurology, Johns Hopkins University School of Medicine Baltimore, MD, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fnsys.2015.00093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479724PMC
July 2015

Effects of Neonatal Hypoxic-Ischemic Injury and Hypothermic Neuroprotection on Neural Progenitor Cells in the Mouse Hippocampus.

Dev Neurosci 2015 13;37(4-5):428-39. Epub 2015 Jun 13.

Department of Anesthesiology and Critical Care Medicinee, Johns Hopkins Medical Institutes, Baltimore, Md., USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000430862DOI Listing
May 2016

Tet3 regulates synaptic transmission and homeostatic plasticity via DNA oxidation and repair.

Nat Neurosci 2015 Jun 27;18(6):836-43. Epub 2015 Apr 27.

1] Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. [2] Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. [3] Graduate Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. [4] The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nn.4008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446239PMC
June 2015