Publications by authors named "Hongjie Yuan"

64Publications

Positive allosteric modulators that target NMDA receptors rectify loss-of-function GRIN variants associated with neurological and neuropsychiatric disorders.

Neuropharmacology 2020 10 24;177:108247. Epub 2020 Jul 24.

Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, 30322, USA; Center for Functional Evaluation of Rare Variants (CFERV), Emory University School of Medicine, Atlanta, GA, 30322, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2020.108247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554152PMC
October 2020

Hodgkin-Huxley-Katz Prize Lecture: Genetic and pharmacological control of glutamate receptor channel through a highly conserved gating motif.

J Physiol 2020 Aug 15;598(15):3071-3083. Epub 2020 Jun 15.

Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, 30322, USA.

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http://dx.doi.org/10.1113/JP278086DOI Listing
August 2020

Negative allosteric modulation of GluN1/GluN3 NMDA receptors.

Neuropharmacology 2020 10 7;176:108117. Epub 2020 May 7.

Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, 30322, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2020.108117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7530031PMC
October 2020

Hypomethylation of nerve growth factor (NGF) promotes binding of C/EBPα and contributes to inflammatory hyperalgesia in rats.

J Neuroinflammation 2020 Jan 24;17(1):34. Epub 2020 Jan 24.

The First Affiliated Hospital of Soochow University, Suzhou, 215006, Jiangsu, People's Republic of China.

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http://dx.doi.org/10.1186/s12974-020-1711-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982391PMC
January 2020

GRIN2D/GluN2D NMDA receptor: Unique features and its contribution to pediatric developmental and epileptic encephalopathy.

Eur J Paediatr Neurol 2020 Jan 18;24:89-99. Epub 2019 Dec 18.

Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, 30322, USA; Center for Functional Evaluation of Rare Variants (CFERV), Emory University School of Medicine, Atlanta, GA, 30322, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejpn.2019.12.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035963PMC
January 2020

Effect of the Modifications on the Physicochemical and Biological Properties of β-Glucan-A Critical Review.

Molecules 2019 Dec 23;25(1). Epub 2019 Dec 23.

School of Perfume and Aroma Technology, Shanghai Institute of Technology, Shanghai 201418, China.

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http://dx.doi.org/10.3390/molecules25010057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983044PMC
December 2019

Distinct roles of and variants in neurological conditions.

F1000Res 2019 20;8. Epub 2019 Nov 20.

Department of Anaesthesia, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

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http://dx.doi.org/10.12688/f1000research.18949.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6871362PMC
June 2020

Effect of Toll-Like Receptor 4/Myeloid Differentiation Factor 88 Inhibition by Salvianolic Acid B on Neuropathic Pain After Spinal Cord Injury in Mice.

World Neurosurg 2019 Dec 23;132:e529-e534. Epub 2019 Aug 23.

Department of Pain Medicine, Nantong Hospital of Traditional Chinese Medicine, Jiangsu, China. Electronic address:

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http://dx.doi.org/10.1016/j.wneu.2019.08.086DOI Listing
December 2019

A high-performance approach for predicting donor splice sites based on short window size and imbalanced large samples.

Biol Direct 2019 04 11;14(1). Epub 2019 Apr 11.

Hunan Provincial Key Laboratory of Crop Germplasm Innovation and Utilization, Hunan Agricultural University, Changsha, 410128, Hunan, China.

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http://dx.doi.org/10.1186/s13062-019-0236-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460831PMC
April 2019

Effects of microRNA-208a on inflammation and oxidative stress in ketamine-induced cardiotoxicity through Notch/NF-κB signal pathways by CHD9.

Biosci Rep 2019 05 17;39(5). Epub 2019 May 17.

Department of Pain Medicine ,Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine, Xianyang 712000, China.

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http://dx.doi.org/10.1042/BSR20182381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522736PMC
May 2019

Safflower Yellow B Protects Brain against Cerebral Ischemia Reperfusion Injury through AMPK/NF-kB Pathway.

Evid Based Complement Alternat Med 2019 3;2019:7219740. Epub 2019 Feb 3.

Department of Anesthesiology, Shenzhen University General Hospital, Shenzhen University Clinical Medical Academy, Shenzhen University, Shenzhen 518055, China.

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http://dx.doi.org/10.1155/2019/7219740DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378026PMC
February 2019

Synthesis and Preliminary Evaluations of a Triazole-Cored Antagonist as a PET Imaging Probe ([F]N2B-0518) for GluN2B Subunit in the Brain.

ACS Chem Neurosci 2019 05 27;10(5):2263-2275. Epub 2019 Feb 27.

Department of Radiology, Division of Nuclear Medicine and Molecular Imaging , Massachusetts General Hospital and Harvard Medical School , 55 Fruit Street , Boston , Massachusetts 02114 , United States.

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http://dx.doi.org/10.1021/acschemneuro.8b00591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727982PMC
May 2019

Structural elements of a pH-sensitive inhibitor binding site in NMDA receptors.

Nat Commun 2019 01 18;10(1):321. Epub 2019 Jan 18.

WM Keck Structural Biology Laboratory, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 11724, USA.

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http://dx.doi.org/10.1038/s41467-019-08291-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338780PMC
January 2019

Inadvertent Spinal Anesthesia During Ultrasound-Guided Thoracic Paravertebral Nerve Block in a Patient With Nerve Root Sheath Cyst: A Case Report.

A A Pract 2019 Mar;12(6):199-201

Pain Medicine, Nantong Hospital of Traditional Chinese Medicine, Nantong, China.

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http://dx.doi.org/10.1213/XAA.0000000000000883DOI Listing
March 2019

Mutations and Rare Variants Occurring in NMDA Receptors.

Curr Opin Physiol 2018 Apr 27;2:27-35. Epub 2017 Dec 27.

Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1016/j.cophys.2017.12.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945193PMC
April 2018

A novel missense mutation in GRIN2A causes a nonepileptic neurodevelopmental disorder.

Mov Disord 2018 Jul 11;33(6):992-999. Epub 2018 Apr 11.

Department of Pharmacology, Emory University School of Medicine, Rollins Research Center, Atlanta, Georgia, USA.

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http://dx.doi.org/10.1002/mds.27315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105539PMC
July 2018

Corrigendum to "Human GRIN2B variants in neurodevelopmental disorders" [J Pharmacol Sci 132 (2) 115-121].

J Pharmacol Sci 2017 04 12;133(4):280. Epub 2017 Apr 12.

Department of Pharmacology, Emory University School of Medicine, Rollins Research Center, 1510 Clifton Road, Atlanta, GA 30322, USA; Center for Functional Evaluation of Rare Variants (CFERV), Emory University School of Medicine, Rollins Research Center, 1510 Clifton Road, Atlanta, GA 30322, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jphs.2017.04.001DOI Listing
April 2017

encephalopathy: novel findings on phenotype, variant clustering, functional consequences and treatment aspects.

J Med Genet 2017 07 4;54(7):460-470. Epub 2017 Apr 4.

Institute of Human Genetics, University of Leipzig Hospitals and Clinics, Leipzig, Germany.

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http://dx.doi.org/10.1136/jmedgenet-2016-104509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656050PMC
July 2017

Functional Evaluation of a De Novo Mutation Identified in a Patient with Profound Global Developmental Delay and Refractory Epilepsy.

Mol Pharmacol 2017 04 26;91(4):317-330. Epub 2017 Jan 26.

Department of Pharmacology, Rollins Research Center, School of Medicine, Emory University, Atlanta, Georgia (W.C., A.T., H.K., S.F.T., H.Y.); Department of Neurology, Xiangya Hospital, Central South University, Changsha, People's Republic of China (W.C.); Department of Chemistry, Emory University, Atlanta, Georgia (P.B.B.); Center for Functional Evaluation of Rare Variants (CFERV), Rollins Research Center, School of Medicine, Emory University, Atlanta, Georgia (S.F.T., H.Y.)

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http://dx.doi.org/10.1124/mol.116.106781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363715PMC
April 2017

Mechanistic Insight into NMDA Receptor Dysregulation by Rare Variants in the GluN2A and GluN2B Agonist Binding Domains.

Am J Hum Genet 2016 Dec 10;99(6):1261-1280. Epub 2016 Nov 10.

Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA; Center for Functional Evaluation of Rare Variants (CFERV), Emory University School of Medicine, Atlanta, GA 30322, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2016.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142120PMC
December 2016

Human GRIN2B variants in neurodevelopmental disorders.

J Pharmacol Sci 2016 Oct 19;132(2):115-121. Epub 2016 Oct 19.

Department of Pharmacology, Emory University School of Medicine, Rollins Research Center, 1510 Clifton Road, Atlanta, GA 30322, USA; Center for Functional Evaluation of Rare Variants (CFERV), Emory University School of Medicine, Rollins Research Center, 1510 Clifton Road, Atlanta, GA 30322, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jphs.2016.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125235PMC
October 2016

GRIN1 Mutations in Early-Onset Epileptic Encephalopathy.

Pediatr Neurol Briefs 2015 Jun;29(6):44

Department of Pharmacology, Emory University, Atlanta, GA.

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http://dx.doi.org/10.15844/pedneurbriefs-29-6-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747309PMC
June 2015

Ophthalmic branch radiofrequency thermocoagulation for atypical trigeminal neuralgia:a case report.

Springerplus 2015 24;4:813. Epub 2015 Dec 24.

Department of Anesthesiology and Pain Management, Xijing Hospital, Fourth Military Medical University, 710032 Xian, China.

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http://dx.doi.org/10.1186/s40064-015-1624-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690819PMC
January 2016

A novel class of negative allosteric modulators of NMDA receptor function.

Bioorg Med Chem Lett 2015 Dec 19;25(23):5583-8. Epub 2015 Oct 19.

Department of Chemistry, Emory University, 1521 Dickey Drive, Atlanta, GA 30322, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2015.10.046DOI Listing
December 2015

Ionotropic GABA and Glutamate Receptor Mutations and Human Neurologic Diseases.

Mol Pharmacol 2015 Jul 22;88(1):203-17. Epub 2015 Apr 22.

Departments of Pharmacology (H.Y., A.J., S.F.T.) and Anesthesiology (O.A.M., A.J.), Emory University School of Medicine, Rollins Research Center, Atlanta, Georgia; and Departments of Pharmacology and Anaesthesia, Yong Loo Lin School of Medicine, National University of Singapore Graduate School for Integrative Sciences and Engineering, and Neurobiology/Ageing Programme, National University of Singapore, Singapore (C.-M.L.)

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http://dx.doi.org/10.1124/mol.115.097998DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468639PMC
July 2015

mutation and early-onset epileptic encephalopathy: personalized therapy with memantine.

Ann Clin Transl Neurol 2014 Mar;1(3):190-198

NIH Undiagnosed Diseases Program, NIH Office of Rare Diseases Research and NHGRI, Bethesda, MD, USA ; Division of Neurology, Children's Hospital of Philadelphia and Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1002/acn3.39DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019449PMC
March 2014

Distinct functional and pharmacological properties of Triheteromeric GluN1/GluN2A/GluN2B NMDA receptors.

Neuron 2014 Mar;81(5):1084-1096

Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1016/j.neuron.2014.01.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3957490PMC
March 2014

Mapping the binding of GluN2B-selective N-methyl-D-aspartate receptor negative allosteric modulators.

Mol Pharmacol 2012 Aug 17;82(2):344-59. Epub 2012 May 17.

Department of Chemistry, Emory University, 1515 Dickey Dr., Atlanta, GA 30302, USA.

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http://dx.doi.org/10.1124/mol.112.078568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400845PMC
August 2012

Glutamate receptor ion channels: structure, regulation, and function.

Pharmacol Rev 2010 Sep;62(3):405-96

Department of Pharmacology, Emory University School of Medicine, Rollins Research Center, 1510 Clifton Road, Atlanta, GA 30322-3090, USA.

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http://pharmrev.aspetjournals.org/cgi/doi/10.1124/pr.109.002
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http://dx.doi.org/10.1124/pr.109.002451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964903PMC
September 2010

Control of NMDA receptor function by the NR2 subunit amino-terminal domain.

J Neurosci 2009 Sep;29(39):12045-58

Department of Pharmacology, Emory University School of Medicine, Rollins Research Center, Atlanta, Georgia 30322-3090, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.1365-09.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776059PMC
September 2009

The serine protease plasmin cleaves the amino-terminal domain of the NR2A subunit to relieve zinc inhibition of the N-methyl-D-aspartate receptors.

J Biol Chem 2009 May 24;284(19):12862-73. Epub 2009 Feb 24.

Department of Pharmacology, Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322-3090, USA.

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http://dx.doi.org/10.1074/jbc.M805123200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676017PMC
May 2009

Subunit-specific agonist activity at NR2A-, NR2B-, NR2C-, and NR2D-containing N-methyl-D-aspartate glutamate receptors.

Mol Pharmacol 2007 Oct 10;72(4):907-20. Epub 2007 Jul 10.

Department of Pharmacology, Emory University School of Medicine, 5025 Rollins Research Center, 1510 Clifton Road, Atlanta GA 30322-3090, USA.

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http://dx.doi.org/10.1124/mol.107.037333DOI Listing
October 2007

Exacerbation of dopaminergic terminal damage in a mouse model of Parkinson's disease by the G-protein-coupled receptor protease-activated receptor 1.

Mol Pharmacol 2007 Sep 27;72(3):653-64. Epub 2007 Jun 27.

Department of Pharmacology, Emory University School of Medicine, 5025 Rollins Research Center, 1510 Clifton Road, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1124/mol.107.038158DOI Listing
September 2007

Structural aspects of AMPA receptor activation, desensitization and deactivation.

Curr Opin Neurobiol 2007 Jun 6;17(3):281-8. Epub 2007 Apr 6.

Department of Pharmacology, Emory University School of Medicine, Rollins Research Center, 1510 Clifton Road, Atlanta, GA 30322, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S095943880700046
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http://dx.doi.org/10.1016/j.conb.2007.03.014DOI Listing
June 2007

Astrocytic control of synaptic NMDA receptors.

J Physiol 2007 Jun 5;581(Pt 3):1057-81. Epub 2007 Apr 5.

Center for Neural Science, Division of Life Sciences, Korea Institute of Science and Technology, Seoul, Korea.

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http://doi.wiley.com/10.1113/jphysiol.2007.130377
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http://dx.doi.org/10.1113/jphysiol.2007.130377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2170820PMC
June 2007

Subunit-specific mechanisms and proton sensitivity of NMDA receptor channel block.

J Physiol 2007 May 15;581(Pt 1):107-28. Epub 2007 Feb 15.

Department of Pharmacology, Emory University School of Medicine, Rollins Research Centre, 1510 Clifton Road, Atlanta, GA 30322-3090, USA.

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http://dx.doi.org/10.1113/jphysiol.2006.124958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2075223PMC
May 2007

Conserved structural and functional control of N-methyl-D-aspartate receptor gating by transmembrane domain M3.

J Biol Chem 2005 Aug 21;280(33):29708-16. Epub 2005 Jun 21.

Department of Pharmacology, Emory University School of Medicine, Rollins Research Center, Atlanta, Georgia 30322-3090, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M414215200
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http://dx.doi.org/10.1074/jbc.M414215200DOI Listing
August 2005

Glucose sensitivity in mouse substantia nigra pars reticulata neurons in vitro.

Neurosci Lett 2004 Jan;355(3):173-6

Department of Physiology, Akita University School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan.

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http://dx.doi.org/10.1016/j.neulet.2003.10.068DOI Listing
January 2004

Multiminute oscillations in mouse substantia nigra pars reticulata neurons in vitro.

Neurosci Lett 2004 Jan;355(1-2):136-40

Department of Physiology, Akita University School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan.

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http://dx.doi.org/10.1016/j.neulet.2003.10.058DOI Listing
January 2004

[Studies on hydantoinase producing conditions of Arthrobacter K1108].

Wei Sheng Wu Xue Bao 2002 Apr;42(2):214-9

Institute of Biotechnology, Beijing, 100071, China.

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April 2002