Publications by authors named "Hongjian Liu"

106 Publications

Long non-coding RNA CCAT2 drives the growth of laryngeal squamous cell carcinoma via regulating YAP activity.

Hum Cell 2021 Sep 13. Epub 2021 Sep 13.

Department of Otolaryngology, People's Hospital of Henan Province, 7 Weiwu Road, Zhengzhou, 450003, Henan, People's Republic of China.

Emerging evidence suggests that long non-coding RNA (lncRNA) is closely associated with numerous human diseases, including cancer. However, the functional relevance of lncRNA in human laryngeal squamous cell carcinoma (LSCC) is largely unknown. In the current study, we described CCAT2, a previously unappreciated oncogenic lncRNA in LSCC. CCAT2 was significantly upregulated in human LSCC tissue and serum samples, associated with larger tumor volume, higher clinical stage, and poorer differentiation status. Lentivirus-mediated CCAT2 knockdown notably repressed the cell viability, colony formation, and DNA synthesis rate of LSCC. Screening of transcription factors revealed that YAP/TEAD activity was affected by CCAT2 in LSCC cells. Further, CCAT2 directly binds to YAP protein and blocks the phosphorylation of YAP induced by LATS1, resulting in the nuclear translocation of YAP and the activation of YAP oncogenic targets, such as CTGF, CYR61 and AMOTL2. Importantly, we also confirmed the regulation of CCAT2 on YAP activity in vivo based on nude mice model. Altogether, we identified a novel lncRNA that controls YAP nucleocytoplasmic shuttling and promotes LSCC cell proliferation. Given the importance of YAP in tumorigenesis and progression, our results provide insights to intervene LSCC by targeting the CCAT2/YAP axis.
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http://dx.doi.org/10.1007/s13577-021-00606-zDOI Listing
September 2021

Associations of body mass index, waist circumference and waist-to-height ratio with cognitive impairment among Chinese older adults: Based on the CLHLS.

J Affect Disord 2021 Sep 4;295:463-470. Epub 2021 Sep 4.

Department of Social Medicine and Health Management, School of Public Health, Jilin University, Changchun, China. Electronic address:

Background: Few studies have been conducted on the associations of body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHtR) with cognitive impairment among Chinese older adults through a prospective design.

Objective: This study was aimed to evaluate the associations of BMI, WC, and WHtR with cognitive impairment.

Methods: We included participants aged 65 years and older in 2014 at baseline and 2018 follow-up surveys of the Chinese Longitudinal Healthy Longevity Survey (CLHLS). BMI, WC, and WHtR were calculated from measured weight, height, and waist circumference. Mini-Mental State Examination was utilized to assess cognitive impairment. Modified Poisson regression was used for calculating prevalence ratios, risk ratios, and 95% confidence intervals.

Results: A total of 5156 participants were included in 2014 at baseline. The prevalence of cognitive impairment was 42.5%, 26.7%, and 21.2% in underweight, normal-weight, and overweight/obesity participants defined by BMI categories, respectively, and 24.1% and 26.8% in central obesity participants defined by WC and WHtR cutoffs, respectively. Prospectively, participants with underweight were more likely to suffer from cognitive impairment (RR = 1.258, 95% CI: [1.016, 1.559]), but no risk was found among participants with overweight/obesity after adjustment. Regardless of whether covariates were adjusted or not, no effect on cognitive impairment was found in participants with WC and WHtR groups in the follow-up survey.

Conclusions: Underweight may be a significant risk factor for the cognitive impairment of Chinese older adults. Weight management programs targeting older adults should attach importance to achieving and maintaining optimal body weight and improving cognitive function.
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http://dx.doi.org/10.1016/j.jad.2021.08.093DOI Listing
September 2021

Associations of negative life events and coping styles with sleep quality among Chinese adolescents: a cross-sectional study.

Environ Health Prev Med 2021 Sep 4;26(1):85. Epub 2021 Sep 4.

Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China.

Background: Limited published research has examined the relationships of negative life events and coping styles with sleep quality in Chinese junior high school students. We aimed to investigate the prevalence of poor sleep quality and to clarify the role of coping styles between negative life events and sleep quality.

Methods: A cross-sectional study of 3081 students was conducted in Ganzhou City, Jiangxi Province, Southeastern China. Adolescent Self-Rating Life Events Checklist, Simplified Coping Style Questionnaire, and Pittsburg Sleep Quality Index were applied to assess negative life events, coping styles, and sleep quality, respectively. Descriptive analyses, independent-samples t tests, one-way analyses of variance, Pearson correlation analyses, and structural equation modeling (SEM) were applied to analyze the data.

Results: The prevalence of poor sleep quality was 26.7%. Negative life events (B = 0.038, P < 0.001) and negative coping style (B = 0.049, P < 0.001) demonstrated a positive association with poor sleep quality, while positive coping style indicated a negative association with poor sleep quality (B = -0.029, P < 0.001). Interactions of negative life events and coping styles with sleep quality were not found (all P > 0.05). The association between negative life events and sleep quality was mediated by negative coping styles.

Conclusions: Our results indicated that poor sleep quality was common in these Chinese adolescents. Negative life events and negative coping style were associated with an increased prevalence of poor sleep quality, while the positive coping style was related to a decreased prevalence of poor sleep quality. A negative coping style mediated the association between negative life events and sleep quality.
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http://dx.doi.org/10.1186/s12199-021-01007-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8418725PMC
September 2021

Base-Promoted Three-Component Cascade Reaction of α-Hydroxy Ketones, Malonodinitrile, and Alcohols: Direct Access to Tetrasubstituted N-Pyrroles.

J Org Chem 2021 Jul 6;86(14):9610-9620. Epub 2021 Jul 6.

Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, People's Republic of China.

A base-promoted three-component cascade reaction of α-hydroxy ketones, malonodinitrile, and alcohols has been developed, providing a direct and efficient route to a range of structurally diverse and synthetically useful 2-alkyloxy-1-pyrrole-3-carbonitrile derivatives. The reaction involved three different bond (C-C, C-O, and C-N) formations in a single step, and its regioselectivity was depended on the structure of the α-hydroxy ketones employed. The use of easily available starting materials, wide substrate scope, good functional group tolerance, operational simplicity, and high atom economy are attractive features of the new method.
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http://dx.doi.org/10.1021/acs.joc.1c00882DOI Listing
July 2021

The prevalence of depressive symptoms and associated factors in middle-aged and elderly Chinese people.

J Affect Disord 2021 10 25;293:222-228. Epub 2021 Jun 25.

Department of Social Medicine and Health Management, School of Public Health, Jilin University, Changchun, China. Electronic address:

Background: This study aimed to evaluate the prevalence of depressive symptoms and associated factors in middle-aged and elderly people in China.

Methods: Data were obtained from the China Family Panel Studies (CFPS) 2018. We selected 16,767 respondents over the age of 45 as samples for research and analysis. A short version of the Center for Epidemiological Research Depression Scale (CES-D) was used to assess depressive symptoms. Chi-square test and multiple logistic regression analysis were used to explore the related factors of depressive symptoms. Back Propagation neural network model was established to examine the ranking of influencing factors of depressive symptoms.

Results: There was 24.1% prevalence of depressive symptoms among the respondents. The 14 important variables affecting depressive symptoms were screened out with the multivariable logistic regression. Based on the BP neural network to rank the degree of importance, the top five important variables were determined, which were subjective well-being (100.0%), self-reported health (92.0%), life satisfaction (83.4%), ADL disability (74.0%), and marital status (69.7%).

Limitations: This study was a cross-sectional study, and causality cannot be determined.

Conclusions: The prevalence of depressive symptoms in middle-aged and elderly Chinese people was high. Subjective quality of life evaluation, health condition and marital status were important factors that have an impact on depressive symptoms.
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http://dx.doi.org/10.1016/j.jad.2021.06.044DOI Listing
October 2021

The function of miR-637 in non-small cell lung cancer progression and prognosis.

Pulmonology 2021 Jun 24. Epub 2021 Jun 24.

Department of Ultrasound, Binzhou Medical University Hospital, No.661, Huanghe 2nd Road, Binzhou, Shandong 256003, China. Electronic address:

Background: Non-small cell lung cancer (NSCLC) is the most common type of lung cancer with a high mortality rate and poor prognosis. miR-637 has been reported to regulate tumor progression and act as a prognosis biomarker of various cancers. Its functional role in NSCLC was investigated in this study.

Methods: The expression level of miR-637 in NSCLC tissues and adjacent normal tissues of 123 NSCLC patients was analyzed by qRT-PCR. The association between miR-637 and clinical pathological features in the prognosis of patients was analyzed. Cell transfection was performed to overexpress or knockdown miR-637 in H1299 and HCC827. The proliferation, migration, and invasion of H1299 and HCC827 were evaluated by CCK8 and Transwell assay.

Results: miR-637 expression was significantly decreased in NSCLC tissues and cell lines relative to normal tissues and cells. The survival rate of NSCLC patients with low miR-637 expression was lower than that of patients with high miR-637 expression. Additionally, miR-637 served as a tumor suppressor that inhibited cell proliferation, migration, and invasion of NSCLC.

Conclusion: Downregulation of miR-637 in NSCLC was associated with TNM stage and poor prognosis of patients and served as a tumor suppressor in NSCLC. These results provide a potential strategy to control NSCLC.
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http://dx.doi.org/10.1016/j.pulmoe.2021.05.005DOI Listing
June 2021

AS1 expression in prostate cancer and its effects on proliferation and invasion of prostate cancer cells.

Cancer Biomark 2021 Jun 12. Epub 2021 Jun 12.

Department of Urology Surgery, Qingdao Women and Children's Hospital, Qingdao, Shandong, China.

This paper aimed at investigating AS1 expression in prostate cancer (PCa) and its effects on the proliferation and invasion of prostate cancer cells (PCCs). The prostate tissues and the matched adjacent normal prostate tissues excised and preserved during radical prostatectomy in our hospital were collected. The LncRNA NCK1-AS1 expression was detected. PCa patients were followed up for three years to analyze their prognosis. The correlation of LncRNA NCK1-AS1 expression with clinicopathological features was analyzed. Human normal prostate cells and human PCCs were selected, in which LncRNA NCK1-AS1 expression was tested to screen and then transfect the cells. Cell proliferation, invasion and migration were detected. Cell cycles and apoptosis were analyzed. Compared with the adjacent normal tissues, LncRNA NCK1-AS1 was highly expressed in the prostate cancer tissues. Its expression was remarkably different in those with different stages of TNM and with lymphatic metastasis or not. The prognosis of patients with high LncRNA NCK1-AS1 expression was remarkably poorer than that of those with low expression. Compared with the human normal prostate cells, LncRNA NCK1-AS1 expression in the human PCCs remarkably rose, with the greatest difference in 22Rv1 cells. Compared with the Blank group, cell proliferation and the number of plate cloned cells remarkably reduced in the sh-NCK1-AS1 group. Additionally, in this group, the number of invasive and migratory cells remarkably reduced; the expression of invasion-related protein E-cadherin remarkably rose but that of MMP-2 remarkably reduced; cell cycles were arrested and the expression of cycle-related proteins (CDK4, CDK6, cyclin D1) remarkably reduced; the apoptotic rate and the expression of apoptosis-related protein Bax remarkably rose. LncRNA NCK1-AS1 is highly expressed in PCa, so its down-regulation can inhibit PCCs from proliferating and reduce the number of invasive cells.
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http://dx.doi.org/10.3233/CBM-203021DOI Listing
June 2021

Long non-coding RNA KCNQ1 overlapping transcript 1 promotes the progression of esophageal squamous cell carcinoma by adsorbing microRNA-133b.

Clinics (Sao Paulo) 2021 26;76:e2175. Epub 2021 Apr 26.

Department of Thoracic Surgery, Binzhou Medical University Hospital, Binzhou, Shandong 256603, China.

Objective: The long non-coding RNA (lncRNA) KCNQ1 overlapping transcript 1 (KCNQ1OT1) exerts vital regulatory functions in diverse tumors. However, the biological function of KCNQ1OT1 in esophageal squamous cell carcinoma (ESCC) remains unclear.

Methods: KCNQ1OT1 expression was detected in ESCC tissues using quantitative real-time polymerase chain reaction (qRT-PCR). Cell proliferation, apoptosis, migration, and invasion were detected by the CCK-8 assay, EdU assay, flow cytometry analysis, and Transwell experiments, respectively. Bioinformatics analysis, luciferase reporter experiments, and RNA immunoprecipitation assays were used to predict and validate the regulatory relationships between KCNQ1OT1, microRNA-133b (miR-133b) and epidermal growth factor receptor (EGFR).

Results: KCNQ1OT1 expression was remarkably upregulated in ESCC tissues and cell lines. Overexpression of KCNQ1OT1 markedly promoted ESCC cell proliferation, migration, and invasion and enhanced the expression of N-cadherin, MMP-2, and MMP-9, but inhibited apoptosis and E-cadherin expression in ESCC cell lines; KCNQ1OT1 knockdown exerted the opposite effects. KCNQ1OT1 could directly bind to miR-133b and suppress its expression, and miR-133b reversed the effects of KCNQ1OT1 overexpression in ESCC cells. MiR-133b reduced the expression of epidermal growth factor receptor (EGFR); further, KCNQ1OT1 activated the phosphatidylinositol 3-kinase/AKT serine/threonine kinase 1 (PI3K/AKT) signaling pathway by repressing miR-133b repression and indirectly upregulating EGFR. KCNQ1OT1 expression was positively correlated with EGFR mRNA expression and negatively correlated with miR-133b expression.

Conclusion: KCNQ1OT1 facilitates ESCC progression by sponging miR-133b and activating the EGFR/PI3K/AKT pathway.
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http://dx.doi.org/10.6061/clinics/2021/e2175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8050598PMC
May 2021

Relationships of organisational justice, psychological capital and professional identity with job burnout among Chinese nurses: A cross-sectional study.

J Clin Nurs 2021 Oct 7;30(19-20):2912-2923. Epub 2021 Apr 7.

Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China.

Aims And Objectives: The present study was aimed at describing the status of job burnout and exploring the mediating roles of psychological capital and professional identity on the association between organisational justice and job burnout.

Background: With the shortage of nurses all over the world, nurses' job burnout has become the focus of studies in recent years. However, limited published research has examined the mediating roles of psychological capital and professional identity on the association between organisational justice and job burnout within hospital contexts in China.

Design: A cross-sectional design.

Methods: A total of 1,009 nurses were enrolled from a major general hospital located in Qiqihar City in the northeast of China from March-July 2018, and asked to complete questionnaires regarding organisational justice, psychological capital, professional identity and job burnout. The STROBE checklist was adhered to in this study.

Results: It was observed that the overall proportion of nurses with job burnout was 58.8%. All the correlations among organisational justice, psychological capital, professional identity and job burnout were statistically significant, with coefficients ranging between -0.487-0.863. Psychological capital and professional identity had indirect effects equal to -0.072 and -0.142, respectively, on the association between organisational justice and job burnout, taking up 13.7% and 26.9% of the total effect, respectively. The serial indirect effect of psychological capital and professional identity was -0.129, accounting for 24.5% of the total effect.

Conclusions: This study showed the necessity of addressing the status of job burnout among Chinese nurses. Psychological capital and professional identity may mediate the linkage between organisational justice and job burnout independently and accumulatively.

Relevance To Clinical Practice: Nursing managers should strengthen organisational justice and improve the psychological capital and professional identity of nurses through effective strategies to prevent the job burnout of nurses.
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http://dx.doi.org/10.1111/jocn.15797DOI Listing
October 2021

Input-to-State Stabilization of Stochastic Markovian Jump Systems Under Communication Constraints: Genetic Algorithm-Based Performance Optimization.

IEEE Trans Cybern 2021 Apr 6;PP. Epub 2021 Apr 6.

This work investigates the stabilization problem of uncertain stochastic Markovian jump systems (MJSs) under communication constraints. To reduce the bandwidth usage, a discrete-time Markovian chain is employed to implement the stochastic communication protocol (SCP) scheduling of the sensor nodes, by which only one sensor node is chosen to access the network at each transmission instant. Moreover, due to the effect of amplitude attenuation, time delay, and random interference/noise, the transmission may be inevitably subject to the Rice fading phenomenon. All of these constraints make the controller only receive the fading signal from one activated sensor node at each instant. A merge approach is first used to deal with two Markovian chains; meanwhile, a compensator is designed to provide available information for the controller. By a compensator and mode-based sliding-mode controller, the resulting closed-loop system is ensured to be input-to-state stable in probability (ISSiP), and the quasisliding mode is attained. Moreover, an iteration optimizing algorithm is provided to reduce the convergence domain around the sliding surface via searching a desirable sliding gain, which constitutes an effective GA-based sliding-mode control strategy. Finally, the proposed control scheme is verified via the simulation results.
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http://dx.doi.org/10.1109/TCYB.2021.3066509DOI Listing
April 2021

Establishment and associated factors of health records among young Chinese migrants.

Environ Health Prev Med 2021 Mar 24;26(1):39. Epub 2021 Mar 24.

Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, 130021, China.

Background: Most Chinese migrants have been faced with obstacles to getting access to local public health services. Young migrants among internal migrants make a major contribution to the economy. However, the establishment of their health records has been ignored. This research was aimed at exploring the status and associated factors of the establishment of health records among young Chinese migrants.

Methods: Data were obtained from the 2017 China Migrants Dynamic Survey (CMDS). Chi-square test and binary logistic regression were performed to investigate the associated factors of the establishment of health records among young Chinese migrants.

Results: Approximately 30.2% of young migrants had their health records established in inflow communities. Urban residence, medical insurance (insured), and lower average monthly household income were attributed to the establishment of more health records. Young migrants who were in northeast China and across provinces and immigrated for working or engaging in trade were less likely to have health records established. Young migrants who participated in social activities and public affairs activities and took type of people in touch as natives in the inflow area showed a higher possibility of establishing health records. Meanwhile, receiving health education and hearing about national basic public health services (BPHSs) were beneficial for establishing the health records of more young migrants.

Conclusion: This study showed that the health records of young migrants had a relatively low establishment rate. Sociodemographic and migration characteristics, health status, public health services, and social integration factors were all related to the health record establishment of young Chinese migrants.
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http://dx.doi.org/10.1186/s12199-021-00961-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7989406PMC
March 2021

Curcumin Modulates the Crosstalk Between Macrophages and Bone Mesenchymal Stem Cells to Ameliorate Osteogenesis.

Front Cell Dev Biol 2021 9;9:634650. Epub 2021 Feb 9.

Department of Orthopaedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Bone healing is thought to be influenced by the cross-talk between bone forming and immune cells. In particular, macrophages play a crucial role in the regulation of osteogenesis. Curcumin, the major bioactive polyphenolic ingredient of turmeric, has been shown to regulate inflammatory response and osteogenic activities. However, whether curcumin could regulate macrophage polarization and subsequently influence osteogenesis remain to be elucidated. In this study, the potential immunomodulatory capability of curcumin on inflammatory response and phenotype switch of macrophages and the subsequent impact on osteogenic differentiation of MSCs are investigated. We demonstrated that curcumin exhibited significant anti-inflammatory effect by polarizing the macrophages toward anti-inflammatory phenotype, with increased expression of IL-4, IL-10, and CD206, and decreased expression of IL-1β, TNF-α, CCR7, and iNOS. In addition, curcumin could improve the osteo-immune microenvironment promoting osteogenesis-related regenerative cytokine BMP-2 and TGF-β production. Moreover, the co-cultured test of macrophages and BMSCs showed that curcumin-modulated macrophages conditioned medium could promote osteogenic differentiation of BMSCs with increased gene (ALP, Runx-2, OCN, and OPN) and protein (Runx-2 and OCN) expression levels, enhanced ALP activity, and obvious formation of mineralized nodules. Taken together, with the interaction between curcumin-conditioned macrophage and curcumin-stimulated BMSCs, curcumin could remarkably enhance the osteogenic differentiation of BMSCs in LPS-activated inflammatory macrophage-BMSCs coculture system.
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http://dx.doi.org/10.3389/fcell.2021.634650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7900185PMC
February 2021

Resveratrol-enhanced SIRT1-mediated osteogenesis in porous endplates attenuates low back pain and anxiety behaviors.

FASEB J 2021 03;35(3):e21414

Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Low back pain (LBP) is a major clinical problem that lacks effective treatments. The sensory innervation in porous vertebral endplates and anxiety contributes to spinal hyperalgesia. We hypothesized that SIRT1 activator resveratrol alleviates LBP and anxiety via promotion of osteogenesis in the porous endplates. The hyperalgesia and anxiety-related behaviors; sensory innervation, inflammation and porosity of endplates; and osteogenic/osteoclastic factors expression were measured following resveratrol treatment after lumbar spine instability (LSI) surgery. To explore whether resveratrol promotes endplates osteogenesis and thus alleviates LBP through activation of SIRT1 in the osteoprogenitor cells of endplates, SIRT1 mice were employed. Additionally, the levels of inflammation markers, phosphorylation of cAMP response element-binding protein (pCREB), and brain-derived neurotrophic factor (BDNF) in hippocampus were evaluated. After 4 or 8 weeks LSI surgery, the mice suffered from hyperalgesia and anxiety, which were efficiently attenuated by resveratrol at 8 weeks. Resveratrol treatment-enhanced osteogenesis and decreased endplates porosities accompanied with the reduction of TNFα, IL-1β, and COX2 levels and CGRP+ nerve fibers innervation in porous endplates. Resveratrol-mediated endplates osteogenesis, decreased endplates porosities, and analgesic and antianxiety effects were abrogated in SIRT1 mice. Furthermore, resveratrol relieved inflammation and increased pCREB and BDNF expression in the hippocampus after 8 weeks, which alleviate anxiety-related behaviors. This study provides that resveratrol-mediated porous endplates osteogenesis via the activation of SIRT1 markedly blocked sensory innervation and inflammation in endplates, therefore, alleviating LSI surgery-induced LBP and hippocampus-related anxiety.
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http://dx.doi.org/10.1096/fj.202002524RDOI Listing
March 2021

[Genotype and clinical phenotype analysis of 42 patients with delayed nonsyndromic hearing loss].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Feb;35(2):131-136

Department of Otolaryngology Head and Neck Surgery,Henan Provincial People's Hospital,Zhengzhou University People's Hospital,Henan University People's Hospital.

The aim of this study is to analyze the mutation characteristics of GJB2 and SLC26A4 gene in patients with delayed non-syndromic hearing loss, which is beneficial to the early detection and intervention of delayed deafness. Sanger sequencing technology was used to detect two common genes in 139 patients with non-syndromic deafness, six hot spot mutations in GJB2 gene and SLC26A4 gene, and single heterozygous mutations found in GJB2 gene and SLC26A4 gene were detected by whole exome sequencing. Among the 25 patients with deafness caused by GJB2 gene mutation, 12 of them passed universal newborn hearing screening and then developed delayed extremely severe hearing loss. The onset time of hearing loss was 6-48 months. All the genotypes were homozygous or compound heterozygous mutation of c. 235delC, especially genotype of GJB2 c. 235delC homozygous and c. 235delC/c. 299-300 delAT compound heterozygous mutations, and the CT manifestations were normal. Among the 42 patients with deafness caused by SLC26A4 gene mutation, 30 of them passed universal newborn hearing screening and developed delayed deafness. The onset time of hearing loss was three months to ten years old. Among them, the genotypes of 21 patients were compound heterozygous mutation, and 9 patients were homozygous mutation of c. 919-2A>G, especially genotypes were SLC26A4 c. 919-2A>G/c. 665G>T and c. 919-2A>G /c. 2027T>A compound heterozygous mutation. The CT findings of 19 cases showed single enlarged vestibular aqueduct, and 11 cases showed enlarged vestibular aqueduct with Mondini malformation. For the children who have passed universal newborn hearing screening, the genotypes detected are GJB2 c. 235delC homozygous, SLC26A4 c. 919-2A>G homozygous or compound heterozygous mutations, especially genotypes GJB2 c. 235delC homozygous, c. 235delC/c. 299-300delAT compound heterozygous mutations and SLC26A4 c. 919-2A>G/c. 665G>T and c. 919-2A>G/c. 2027T>A compound heterozygous mutation. Attention should be paid to the hearing problems of children all the time, and the possibility of delayed deafness in the future should be considered.
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http://dx.doi.org/10.13201/j.issn.2096-7993.2021.02.009DOI Listing
February 2021

[Analysis of clinical characteristics of 87 patients with cochlear migraine].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Feb;35(2):112-115

Department of Otorhinolaryngology Head and Neck Surgery,Henan Provincial People's Hospital,People's Hospital of Zhengzhou University,People's Hospital of Henan University,Zhengzhou,450003,China.

The aim of this study is to analyze the clinical features of cochlear migraine. The clinical data of cases of cochlear migraine were collected, and the clinical symptoms and hearing examination results were analyzed. The ratio of male to female patients with cochlear migraine was 1∶3.1; the peak incidence was between 30 to 60 years old; the clinical symptoms were tinnitus in 61 people(70%), mild hearing loss in 52 people(60%), aural fullness in hyperacusis in 13 people(15%), auditory allergy in 9 people(10%) and otalgia in 5 people(6%); the audiology characteristic was that 61.5%(32/52) of patients with hearing loss showed mild high-frequency neurological hearing loss, 34.6%(18/52) of patients showed mild low-frequency neurological hearing loss, and 3.8%(2/52) of patients showed full-frequency mild neurological hearing loss; the effective rate of tinnitus treatment was 57.4%, the effective rate of hearing loss was 71.2%, and the effective rate of aural fullness was 69.2%, the effective rate of hyperacusis is 66.7% and the effective rate of otalgia is 60.0%. The clinical characteristics of cochlear migraine are summarized, which provides a basis for the intervention of anti-migraine treatment programs for inner ear diseases.
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http://dx.doi.org/10.13201/j.issn.2096-7993.2021.02.005DOI Listing
February 2021

Identification of novel biomarkers and candidate small-molecule drugs in cutaneous melanoma by comprehensive gene microarrays analysis.

J Cancer 2021 1;12(5):1307-1317. Epub 2021 Jan 1.

Department of Orthopaedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

Melanoma is a pernicious skin cancer with high aggressiveness. This study aimed to identify potential novel biomarkers associated with the prognosis and pathogenesis of cutaneous melanoma and to explore new targeted drugs for melanoma. Two Gene Expression Omnibus (GEO) microarray datasets, GSE3189 and GSE7553 were combined to analyze the differentially expressed genes (DEGs). To better understand the DEGs in the melanoma pathogenesis, we performed gene enrichment analyses and established a protein-protein interaction network (PPI). The survival analyses for key genes were conducted based on the GEPIA platform. Finally, we mined the CMap database to explore potential small-molecule drugs to target the obtained DEGs. In short, we identified 500 DEGs between cutaneous melanoma samples and normal samples. The PPI network was established with 349 nodes and 1251 edges. Signaling pathway analysis showed that these genes play a vital role in ECM-receptor interactions, the PPAR signaling pathway and pathways in cancer. Eight DEGs with a relatively high degree of connectivity (CDC45, CENPF, DTL, FANCI, GINS2, HJURP, TPX2 and TRIP13) were selected as hub-genes that remarkably correlated to a poor survival rate. Based on 500 DEGs, 20 small-molecule drugs that potentially target genes with abnormal expression in cutaneous melanoma were obtained from the CMap database. Among these compounds, we found that menadione has the greatest therapeutic value for melanoma. : In conclusion, we identified the 8 candidate biomarkers and potential key signaling pathways in cutaneous melanoma through comprehensive microarray analyses. The identified candidate drugs have provided several directive significances for the synthesis medicine for melanoma.
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http://dx.doi.org/10.7150/jca.49702DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7847648PMC
January 2021

Relationships of professional identity and psychological reward satisfaction with subjective well-being among Chinese nurses.

J Nurs Manag 2021 Jan 27. Epub 2021 Jan 27.

Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China.

Aim: This study aimed at exploring the impact of professional identity and psychological reward satisfaction on subjective well-being and clarifying the effect of psychological reward satisfaction on this relationship.

Background: People know little about the effect of psychological reward satisfaction on the relationship between professional identity and subjective well-being.

Methods: A cross-sectional survey was carried out on 1,009 nurses from Qiqihar City, Heilongjiang Province of China. Professional Identity Scale, Psychological Reward Satisfaction Scale and General Well-Being Schedule were used to assess professional identity, psychological reward satisfaction and subjective well-being, respectively. Associations were explored by using structural equation modelling.

Results: The subjective well-being of 436 (43.2%) nurses was at low and moderate levels. After the adjustment of potential confounding factors, professional identity was still associated with subjective well-being (B = 3.035, β = 0.215, p < .001). Professional identity (r = .308) and psychological reward satisfaction (r = .309) were positively correlated with subjective well-being. Psychological reward satisfaction mediated the association between professional identity and subjective well-being (effect = 0.114, p < .001).

Conclusion: This study suggested that the subjective well-being of nurses should be improved by paying special attention to them and taking targeted support measures.

Implications For Nursing Management: Nursing managers can help enhance the professional identity of nurses by organising nursing education activities, and pay more attention to psychological reward satisfaction to improve the subjective well-being of nurses.
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http://dx.doi.org/10.1111/jonm.13276DOI Listing
January 2021

Synergistic Utilization of Necrostatin-1 and Z-VAD-FMK Efficiently Promotes the Survival of Compression-Induced Nucleus Pulposus Cells via Alleviating Mitochondrial Dysfunction.

Biomed Res Int 2020 8;2020:6976317. Epub 2020 Dec 8.

Department of Orthopaedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

We recently reported that necroptosis contributed to compression-induced nucleus pulposus (NP) cells death. In the current study, we investigated the regulative effect of necroptosis inhibitor Necrostatin-1 on NP cells apoptosis and autophagy. Necrostatin-1, autophagy inhibitor 3-Methyladenine and apoptosis inhibitor Z-VAD-FMK were employed, and NP cells were exposed to 1.0 MPa compression for 0, 24 and 36 h. Necroptosis-associated molecules were measured by Western blot and RT-PCR. Autophagy and apoptosis levels were evaluated by Western blot and quantified by flow cytometry after monodansylcadaverine and Annexin V-FITC/propidium iodide staining, respectively. The cell viability and cell death were also examined. Furthermore, we measured mitochondrial membrane potential (MMP), mitochondrial permeability transition pore (MPTP) and indices of oxidative stress to assess mitochondrial dysfunction. The results established that Necrostatin-1 blocked NP cells autophagy, and 3-Methyladenine had little influence on NP cells necroptosis. The Necrostatin-1+3-Methyladenine treatment exerted almost the same role as Necrostatin-1 in reducing NP cells death. Necrostatin-1 restrained NP cells apoptosis, while Z-VAD-FMK enhanced NP cells necroptosis. The Necrostatin-1+Z-VAD-FMK treatment provided more prominent role in blocking NP cells death compared with Necrostatin-1, consistent with increased MMP, reduced opening of MPTP and oxidative stress. In summary, the synergistic utilization of Necrostatin-1 and Z-VAD-FMK is a very worthwhile solution in preventing compression-mediated NP cells death, which might be largely attributed to restored mitochondrial function.
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http://dx.doi.org/10.1155/2020/6976317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7738793PMC
June 2021

Daphnetin ameliorates glucocorticoid-induced osteoporosis via activation of Wnt/GSK-3β/β-catenin signaling.

Toxicol Appl Pharmacol 2020 12 7;409:115333. Epub 2020 Nov 7.

Department of Orthopaedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. Electronic address:

Glucocorticoids have been widely used in multiple inflammatory and autoimmune diseases. However, long-term glucocorticoid therapy may result in osteoporosis. The present study aimed to evaluate the potential therapeutic effects and investigate the underlying mechanisms of Daphnetin (Daph) on glucocorticoid-induced osteoporosis (GIOP). In vivo, male Sprague Dawley rats were intramuscularly injected with dexamethasone (DEX) to induce GIOP and Daph was given intraperitoneally. Bone histological changes, mineral content, microstructure parameters and bone turnover markers were detected. Gut microbiota composition and intestinal barrier function were further assessed. In vitro, MC3T3-E1 pre-osteoblasts were treated with DEX and the abilities of Daph on osteoblast proliferation, differentiation and mineralization were assessed. A Wnt signaling inhibitor, XAV939, was added additionally to evaluate the effect of Daph on Wnt signaling. The results showed that in vivo, Daph increased the DEX-induced reduction in body weight gain, bone mineral content and microstructure parameters and restored the levels of bone turnover markers in GIOP rats. In vitro, Daph promoted osteoblast proliferation, differentiation and mineralization in DEX-treated MC3T3-E1 pre-osteoblasts. Moreover, Daph activated the Wnt/GSK-3β/β-catenin signaling pathway. XAV939 successfully abolished the beneficial effects of Daph on GIOP in vitro. Besides, Daph showed improvement on gut microbiota disorder and intestinal barrier dysfunction post GIOP. Collectively, these data demonstrated that Daph effectively ameliorates GIOP and the possible mechanism may be that Daph activated Wnt/GSK-3β/β-catenin signaling.
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http://dx.doi.org/10.1016/j.taap.2020.115333DOI Listing
December 2020

Short-term Efficacy of the Percutaneous Vertebroplasty Using a Curved Versus Straight Vertebroplasty Needle in Osteoporotic Vertebral Compression Fractures.

Orthopedics 2021 Jan 3;44(1):e131-e138. Epub 2020 Nov 3.

The purpose of this study was to compare the efficacy of the curved puncture approach with 2 conventional approaches in percutaneous vertebroplasty (PVP) for the treatment of single-level osteoporotic vertebral compression fractures. Ninety-six patients with a single-level thoracolumbar vertebral fracture were surgically treated in the authors' department from February 2016 to February 2018. Patients were randomly divided into 3 groups, including 25 patients who had PVP punctured with a curved vertebroplasty needle (group C), 40 patients with unipedicular PVP with a straight vertebroplasty needle (group U), and 31 patients with bipedicular PVP with a straight vertebroplasty needle (group B). The short-term efficacies of PVP using different vertebroplasty needles were compared. Significant differences were tested preoperatively and postoperatively in vertebral body height variation, visual analog scale score, and Oswestry Disability Index in each of the 3 groups (P<.05). There was no significant difference among the groups in terms of Cobb angle correction and bone cement leakage. Group C and group U were superior to group B in terms of operative time and injected cement volume (P<.05). Twenty-four (96.0%) patients in group C and 29 (93.5%) patients in group B had centered cement distribution without significant differences (P>.05), which was superior to group U (P<.05). Curved puncture PVP achieved a satisfactory clinical outcome for osteoporotic vertebral compression fractures, with the advantages of less operative time, less injected cement volume, and more reasonable cement distribution for stabilization of the affected vertebrae. [Orthopedics. 2021;44(1):e131-e138.].
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http://dx.doi.org/10.3928/01477447-20201012-03DOI Listing
January 2021

Distributed Quasiconsensus Control for Stochastic Multiagent Systems Under Round-Robin Protocol and Uniform Quantization.

IEEE Trans Cybern 2020 Oct 20;PP. Epub 2020 Oct 20.

In this article, the problem of consensus control is investigated for a class of multiagent systems (MASs) with both stochastic noises and nonidentical exogenous disturbances. The signal transmission among agents is implemented through a digital communication network subject to both uniform quantization and round-robin protocol as a reflection of network constraints. The consensus strategy is designed by adopting the estimates of the relative states of the agent to its neighbors, which renders the distributed nature of the controller. A new consensus concept, namely, quasiconsensus in probability, is employed to evaluate the state response of the agents to the stochastic noises, the exogenous disturbances, and the quantization error. An augmented system is first formed that relies on the deviations of the individual state from the average state, the observer error of the relative state, as well as the relative measurement output. Based on the augmented model, an analysis approach on dynamical behaviors is developed to facilitate the consensus analysis of MASs by means of the switching Lyapunov function technique and the stochastic analysis methods. Then, the existence condition and the explicit expression of the time-varying gain matrices are proposed for the expected controller by resorting to the feasibility of several matrix inequalities. Numerical simulation results are presented to demonstrate the applicability of the theoretical results.
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http://dx.doi.org/10.1109/TCYB.2020.3026001DOI Listing
October 2020

A Partial-Node-Based Approach to State Estimation for Complex Networks With Sensor Saturations Under Random Access Protocol.

IEEE Trans Neural Netw Learn Syst 2020 Oct 13;PP. Epub 2020 Oct 13.

In this article, the robust finite-horizon state estimation problem is investigated for a class of time-varying complex networks (CNs) under the random access protocol (RAP) through available measurements from only a part of network nodes. The underlying CNs are subject to randomly occurring uncertainties, randomly occurring multiple delays, as well as sensor saturations. Several sequences of random variables are employed to characterize the random occurrences of parameter uncertainties and multiple delays. The RAP is adopted to orchestrate the data transmission at each time step based on a Markov chain. The aim of the addressed problem is to design a series of robust state estimators that make use of the available measurements from partial network nodes to estimate the network states, under the RAP and over a finite horizon, such that the estimation error dynamics achieves the prescribed H∞ performance requirement. Sufficient conditions are provided for the existence of such time-varying partial-node-based H∞ state estimators via stochastic analysis and matrix operations. The desired estimators are parameterized by solving certain recursive linear matrix inequalities. The effectiveness of the proposed state estimation algorithm is demonstrated via a simulation example.
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http://dx.doi.org/10.1109/TNNLS.2020.3027252DOI Listing
October 2020

Resilient H∞ State Estimation for Discrete-Time Stochastic Delayed Memristive Neural Networks: A Dynamic Event-Triggered Mechanism.

IEEE Trans Cybern 2020 Oct 1;PP. Epub 2020 Oct 1.

In this article, a resilient H∞ approach is put forward to deal with the state estimation problem for a type of discrete-time delayed memristive neural networks (MNNs) subject to stochastic disturbances (SDs) and dynamic event-triggered mechanism (ETM). The dynamic ETM is utilized to mitigate unnecessary resource consumption occurring in the sensor-to-estimator communication channel. To guarantee resilience against possible realization errors, the estimator gain is permitted to undergo some norm-bounded parameter drifts. For the delayed MNNs, our aim is to devise an event-based resilient H∞ estimator that not only resists gain variations and SDs but also ensures the exponential mean-square stability of the resulting estimation error system with a guaranteed disturbance attenuation level. By resorting to the stochastic analysis technique, sufficient conditions are acquired for the expected estimator and, subsequently, estimator gains are obtained via figuring out a convex optimization problem. The validity of the H∞ estimator is finally shown via a numerical example.
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http://dx.doi.org/10.1109/TCYB.2020.3021556DOI Listing
October 2020

Association between lifestyle factors and depressive symptoms among Chinese middle school students: a cross-sectional study.

Psychol Health Med 2020 Sep 21:1-8. Epub 2020 Sep 21.

Department of Social Medicine and Health Management, School of Public Health, Jilin University, Changchun, Jilin, China.

This study aimed to identify the independent contributions of lifestyle factors to depressive symptoms among Chinese middle school students, with a focus on gender differences. A cross-sectional study of 3081 middle school students was conducted in Ganzhou City, Jiangxi Province, China. Students were asked to complete a questionnaire including socio-demographics, lifestyle factors, the Pittsburgh Sleep Quality Index and the Chinese Secondary School Students Depression Scale. The total prevalence of depressive symptoms was 19.9%. Poor quality of sleep, smoking, drinking and longer mobile phone use time were related to increased prevalence of depressive symptoms after adjusting for potential confounders. A significant interaction between gender and quality of sleep on the depressive symptoms was found ( = 0.014). The gender-stratified analysis showed that quality of sleep was significantly associated with depressive symptoms in both genders. However, the effect in males was greater than that in females.
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http://dx.doi.org/10.1080/13548506.2020.1823441DOI Listing
September 2020

H and l-l state estimation for delayed memristive neural networks on finite horizon: The Round-Robin protocol.

Neural Netw 2020 Dec 22;132:121-130. Epub 2020 Aug 22.

Artificial Intelligence Energy Research Institute, Northeast Petroleum University, Daqing 163318, China; Heilongjiang Provincial Key Laboratory of Networking and Intelligent Control, Northeast Petroleum University, Daqing 163318, China. Electronic address:

In this paper, a protocol-based finite-horizon H and l-l estimation approach is put forward to solve the state estimation problem for discrete-time memristive neural networks (MNNs) subject to time-varying delays and energy-bounded disturbances. The Round-Robin protocol is utilized to mitigate unnecessary network congestion occurring in the sensor-to-estimator communication channel. For the delayed MNNs, our aim is to devise an estimator that not only ensures a prescribed disturbance attenuation level over a finite time-horizon, but also keeps the peak value of the estimation error within a given range. By resorting to the Lyapunov-Krasovskii functional method, the delay-dependent criteria are formulated that guarantee the existence of the desired estimator. Subsequently, the estimator gains are obtained via figuring out a bank of convex optimization problems. The validity of our estimator is finally shown via a numerical example.
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http://dx.doi.org/10.1016/j.neunet.2020.08.006DOI Listing
December 2020

Transcriptome Profiling Provides Molecular Insights into Auxin-Induced Adventitious Root Formation in Sugarcane ( spp. Interspecific Hybrids) Microshoots.

Plants (Basel) 2020 Jul 23;9(8). Epub 2020 Jul 23.

Key Laboratory of Sugarcane Biotechnology and Genetic Improvement (Guangxi), Ministry of Agriculture and Rural affairs/Guangxi Key Laboratory of Sugarcane Genetic Improvement/Sugarcane Research Institute, Guangxi Academy of Agricultural Sciences, Nanning 530007, China.

Adventitious root (AR) formation was enhanced following the treatment of sugarcane microshoots with indole-3-butyric acid (IBA) and 1-naphthalene acetic acid (NAA) combined, suggesting that auxin is a positive regulator of sugarcane microshoot AR formation. The transcriptome profile identified 1737 and 1268 differentially expressed genes (DEGs) in the basal tissues (5 mm) of sugarcane microshoots treated with IBA+NAA compared to nontreated control on the 3rd and 7th days post-auxin or water treatment (days post-treatment-dpt), respectively. To understand the molecular changes, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed. This analysis showed that DEGs associated with the pathways were associated with plant hormone signaling, flavonoid and phenylpropanoid biosyntheses, cell cycle, and cell wall modification, and transcription factors could be involved in sugarcane microshoot AR formation. Furthermore, qRT-PCR analysis was used to validate the expression patterns of nine genes associated with root formation and growth, and the results were consistent with the RNA-seq results. Finally, a hypothetical hormonal regulatory working model of sugarcane microshoot AR formation is proposed. Our results provide valuable insights into the molecular processes associated with auxin-induced AR formation in sugarcane.
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http://dx.doi.org/10.3390/plants9080931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465322PMC
July 2020

Virological activity in treatment-naïve HBeAg-negative HBV-infected adult patients: A community-based study in Jiangsu, China.

Medicine (Baltimore) 2020 Jul;99(29):e21179

Jiangsu Province Center for Disease Prevention and Control, Nanjing.

Nowadays most of the hepatitis B virus (HBV) infected population are adults, among which hepatitis B e antigen (HBeAg) negative infection occupied the largest proportion of HBV infection in China. HBeAg-negative patients are heterogeneous, and the corresponding interventions are different. Therefore, it is worth researching the infection characteristics of HBeAg-negative patients to help guide the interventions.A total of 11,738 treatment-naïve HBeAg-negative adult patients were randomly selected, and their demographic and medical history information were collected. The liver biochemistry, and HBV infection biomarkers including hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (anti-HBs), HBeAg, hepatitis B e antibody (anti-HBe), hepatitis B core antibody (anti-HBc), and hepatitis B virus deoxyribonucleic acid (HBV-DNA) levels were tested. The infection characteristics and their influencing factors were explored.Sixty percent of the patients presented HBV-DNA-positive, of which 31.2% had HBV-DNA level higher than 2000 IU/mL, and 16.5% had HBV-DNA level higher than 20,000 IU/mL. HBV-DNA levels tended to increase along with the increasing of age, and the male patients had significant higher HBV-DNA levels than the female patients. Twenty-four percent of the patients had abnormal transaminase. The male patients were more vulnerable to abnormal transaminase (30.0%) than the female patients (18.4%). Fifty-five percent patients with HBV-DNA ≥20,000 IU/mL presented abnormal alanine aminotransferase (ALT) or aspartate transaminase (AST), which was significantly higher than that of patients with HBV-DNA levels below 20,000 IU/mL (19.0-21.7%). Multivariate logistic regression analyses revealed that the male patients and the patients with higher viral load had higher risk of having abnormal liver function.A considerable number of HBeAg-negative patients were virological active and had liver damage. It is necessary and urgent to carry out regular active interventions for the chronic HBV-infected patients.
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http://dx.doi.org/10.1097/MD.0000000000021179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373614PMC
July 2020

Patterns of recurrence in adenocarcinoma of the esophagogastric junction: a retrospective study.

World J Surg Oncol 2020 Jun 27;18(1):144. Epub 2020 Jun 27.

Department of Thoracic Surgery, Binzhou Medical University Hospital, No. 661 Huanghe 2nd Road, Binzhou, 256603, Shandong, People's Republic of China.

Background: The prognosis of adenocarcinoma of the esophagogastric junction (AEG) is poor. Understanding the postoperative recurrence pattern of AEG is helpful to verify the effectiveness of treatment and optimize subsequent treatment, so as to improve prognosis.

Methods: This single-center retrospective study included patients with stage III AEG who underwent surgical treatment between January 2009 and December 2016. According to the different postoperative treatment arm, patients were divided into surgery and surgery plus chemotherapy groups. Recurrence-free survival was used as the outcome to compare the recurrence site and pattern between the groups.

Results: In total, were 306 patients enrolled, 123 in the surgery group and 183 in the surgery plus chemotherapy group. During follow-up (median 17.1 months) of 24 months after surgery, 62.0% of patients had tumor recurrence. The overall recurrence rates in the surgery and surgery plus chemotherapy groups were 86.9% and 77.0%, respectively. The recurrence patterns of both groups were mainly distant metastasis. Postoperative chemotherapy reduced the incidence of hematogenous dissemination from 51.2 to 42.0%. Multivariate Cox analysis showed that the pN stage increased the risk of recurrence, while surgery plus chemotherapy reduced the risk.

Conclusions: Patients with AEG have a risk of hematogenous dissemination after surgery. Postoperative treatment arm and pN stage were independent risk factors in patients with AEG. Surgery plus chemotherapy can improve recurrence-free survival and reduce distant metastasis, but they do not have a beneficial role in controlling local recurrence.
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http://dx.doi.org/10.1186/s12957-020-01917-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321534PMC
June 2020

The relationship between job stress and job burnout: the mediating effects of perceived social support and job satisfaction.

Psychol Health Med 2021 02 10;26(2):204-211. Epub 2020 Jun 10.

Department of Social Medicine and Health Management, School of Public Health, Jilin University , Changchun, China.

Job stress, perceived social support, and job satisfaction are important predictors of job burnout. However, few studies have explored the mechanism of job stress on different dimensions of job burnout through perceived social support and job satisfaction among bank employees. In this study, a total of 1464 Chinese bank employees completed the Job Stress Assessment Scale, Perceived Social Support Scale, Minnesota Job Satisfaction Questionnaire and Maslach Burnout Inventory-General Survey. The results showed that job burnout was positively associated with job stress but negatively associated with perceived social support and job satisfaction. Mediating analyses showed that the mediation of perceived social support was different for job burnout than for different job burnout dimensions. Job satisfaction mediated the relationship between job stress and different job burnout dimensions. In addition, the association between job stress and job burnout was sequentially mediated by perceived social support and job satisfaction.
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http://dx.doi.org/10.1080/13548506.2020.1778750DOI Listing
February 2021

Gender difference in the association of coping styles and social support with psychological distress among patients with end-stage renal disease.

PeerJ 2020 26;8:e8713. Epub 2020 Mar 26.

Department of Social Medicine and Health Management, School of Public Health, Jilin University, Changchun, China.

Objectives: The study aimed to explore the association of coping styles and social support with psychological distress among patients with end-stage renal disease (ESRD) as well as gender differences in these associations.

Methods: A cross-sectional study of 769 ESRD patients was conducted at 25 hospitals in Qiqihar City, China. All information was collected using structured questionnaires that were self-administered by the patients. Patients' psychological health status, coping styles and perceived social support were measured using the 12-item General Health Questionnaire, the Medical Coping Modes Questionnaire and the Multidimensional Scale of Perceived Social Support. Student's test, analysis of variance (ANOVA) and binary logistic regression analysis were used for data analysis.

Results: A total of 72.3% of participants reported psychological distress, and the prevalence of distress was higher in females (77.0%) than in males (68.8%). The usage of the acceptance-resignation coping style was positively related to psychological distress (B = 0.459,  < 0.001). Social support level was negatively associated with psychological distress (B = -0.049,  < 0.001). The use of the confrontation style was negatively related to psychological distress in females (OR = 0.87, 95% CI [0.78-0.96]) but not in males (OR = 0.98, 95% CI [0.91-1.06]) ( for interaction term = 0.007).

Conclusions: Greater use of the acceptance-resignation style and lower social support are related to a higher risk of psychological distress. Greater use of the confrontation style is related to a lower risk of psychological distress in females but not in males.
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http://dx.doi.org/10.7717/peerj.8713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103200PMC
March 2020
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