Publications by authors named "Hong-Wen Deng"

100Publications

Identifying Pleiotropic SNPs Associated With Femoral Neck and Heel Bone Mineral Density.

Front Genet 2020 22;11:772. Epub 2020 Jul 22.

Center for Bioinformatics and Genomics, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, United States.

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http://dx.doi.org/10.3389/fgene.2020.00772DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7388689PMC
July 2020

Four pleiotropic loci associated with fat mass and lean mass.

Int J Obes (Lond) 2020 Jul 27. Epub 2020 Jul 27.

Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Jiangsu, PR China.

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http://dx.doi.org/10.1038/s41366-020-0645-0DOI Listing
July 2020

Network-based Transcriptome-wide Expression Study for Postmenopausal Osteoporosis.

J Clin Endocrinol Metab 2020 Aug;105(8)

Center for Biomedical informatics and Genomics, Department of Medicine, Tulane University, New Orleans, Louisiana.

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http://dx.doi.org/10.1210/clinem/dgaa319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320836PMC
August 2020

Whole-exome sequencing and genome-wide association studies identify novel sarcopenia risk genes in Han Chinese.

Mol Genet Genomic Med 2020 Jun 1:e1267. Epub 2020 Jun 1.

Department of Biostatistics, Tulane University, New Orleans, Louisiana, USA.

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http://dx.doi.org/10.1002/mgg3.1267DOI Listing
June 2020

Identification of pleiotropic genes between risk factors of stroke by multivariate metaCCA analysis.

Mol Genet Genomics 2020 Sep 30;295(5):1173-1185. Epub 2020 May 30.

Department of Global Biostatistics and Data Science, Tulane Center for Bioinformatics and Genomics, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, 70112, USA.

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http://dx.doi.org/10.1007/s00438-020-01692-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394724PMC
September 2020

Medium-coverage DNA sequencing in the design of the genetic association study.

Eur J Hum Genet 2020 May 26. Epub 2020 May 26.

Center for Bioinformatics and Genomics, Department of Biostatistics and Data Science, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, 70112, USA.

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http://dx.doi.org/10.1038/s41431-020-0656-2DOI Listing
May 2020

Malnutrition and its associated factors among elderly Chinese with physical functional dependency.

Public Health Nutr 2020 May 11:1-11. Epub 2020 May 11.

Xiangya School of Nursing, Central South University, Changsha, Hunan410013, China.

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http://dx.doi.org/10.1017/S1368980019005299DOI Listing
May 2020

Two novel pleiotropic loci associated with osteoporosis and abdominal obesity.

Hum Genet 2020 Aug 1;139(8):1023-1035. Epub 2020 Apr 1.

Center for Genetic Epidemiology and Genomics, School of Public Health, Medical College, Soochow University, 199 Ren-ai Rd, Suzhou, 215123, Jiangsu, People's Republic of China.

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http://dx.doi.org/10.1007/s00439-020-02155-1DOI Listing
August 2020

Mendelian Randomization Identifies CpG Methylation Sites With Mediation Effects for Genetic Influences on BMD in Peripheral Blood Monocytes.

Front Genet 2020 28;11:60. Epub 2020 Feb 28.

Center for Bioinformatics and Genomics, Department of Global Biostatistics and Data Science, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, United States.

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http://dx.doi.org/10.3389/fgene.2020.00060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059767PMC
February 2020

Identification of novel functional CpG-SNPs associated with type 2 diabetes and coronary artery disease.

Mol Genet Genomics 2020 May 11;295(3):607-619. Epub 2020 Mar 11.

Department of Biostatistics and Data Science, Center for Bioinformatics and Genomics, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, 70112, USA.

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http://dx.doi.org/10.1007/s00438-020-01651-3DOI Listing
May 2020

Association of 3p27.1 Variants with Whole Body Lean Mass Identified by a Genome-wide Association Study.

Sci Rep 2020 Mar 9;10(1):4293. Epub 2020 Mar 9.

Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, Jiangsu, PR China.

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http://dx.doi.org/10.1038/s41598-020-61272-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062907PMC
March 2020

A trans-ethnic two-stage polygenetic scoring analysis detects genetic correlation between osteoporosis and schizophrenia.

Clin Transl Med 2020 Feb 27;9(1):21. Epub 2020 Feb 27.

Center for Translational Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, No. 277 Yanta West Road, Xi'an, 710061, People's Republic of China.

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http://dx.doi.org/10.1186/s40169-020-00272-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046891PMC
February 2020

Sarcopenia-related traits and coronary artery disease: a bi-directional Mendelian randomization study.

Aging (Albany NY) 2020 02 16;12(4):3340-3353. Epub 2020 Feb 16.

Center for System Biology, Data Sciences, and Reproductive Health, School of Basic Medical Science, Central South University, Yuelu, Changsha, P.R. China.

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http://dx.doi.org/10.18632/aging.102815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066916PMC
February 2020

Osteoporosis- and obesity-risk interrelationships: an epigenetic analysis of GWAS-derived SNPs at the developmental gene .

Epigenetics 2020 Jun - Jul;15(6-7):728-749. Epub 2020 Jan 24.

Tulane Center for Bioinformatics and Genomics, Department of Biostatistics and Data Science, School of Public Health and Tropical Medicine, Tulane University , New Orleans, LA, USA.

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http://dx.doi.org/10.1080/15592294.2020.1716491DOI Listing
January 2020

Quantification of aminobutyric acids and their clinical applications as biomarkers for osteoporosis.

Commun Biol 2020 01 22;3(1):39. Epub 2020 Jan 22.

Bone-Muscle Research Center, College of Nursing and Health Innovation, University of Texas at Arlington, Arlington, TX, 76019, USA.

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http://dx.doi.org/10.1038/s42003-020-0766-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976694PMC
January 2020

A road map for understanding molecular and genetic determinants of osteoporosis.

Nat Rev Endocrinol 2020 02 2;16(2):91-103. Epub 2019 Dec 2.

Center of Bioinformatics and Genomics, Department of Global Biostatistics and Data Science, Tulane University, New Orleans, LA, USA.

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http://dx.doi.org/10.1038/s41574-019-0282-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6980376PMC
February 2020

Two functional variants at 6p21.1 were associated with lean mass.

Skelet Muscle 2019 11 23;9(1):28. Epub 2019 Nov 23.

Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, SuZhou City, People's Republic of China.

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http://dx.doi.org/10.1186/s13395-019-0212-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874818PMC
November 2019

Robust kernel canonical correlation analysis to detect gene-gene co-associations: A case study in genetics.

J Bioinform Comput Biol 2019 08;17(4):1950028

Department of Biomedical Engineering, Tulane University, New Orleans, LA 70118, USA.

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http://dx.doi.org/10.1142/S0219720019500288DOI Listing
August 2019

Race and socioeconomic effect on sarcopenia and sarcopenic obesity in the Louisiana Osteoporosis Study (LOS).

JCSM Clin Rep 2018 Jul-Dec;3(2)

Tulane University, 1440 Canal St., Suite 2001, New Orleans, LA 70112.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712972PMC
August 2019

Geographical differences in osteoporosis, obesity, and sarcopenia related traits in white American cohorts.

Sci Rep 2019 08 23;9(1):12311. Epub 2019 Aug 23.

Center for Bioinformatics and Genomics, Department of Global Biostatistics and Data Science, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, 70112, USA.

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http://dx.doi.org/10.1038/s41598-019-48734-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707235PMC
August 2019

A Statistical Test for Differential Network Analysis Based on Inference of Gaussian Graphical Model.

Sci Rep 2019 07 26;9(1):10863. Epub 2019 Jul 26.

Center for Bioinformatics and Genomics, Department of Global Biostatistics and Data Science, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, 70112, USA.

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http://dx.doi.org/10.1038/s41598-019-47362-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659630PMC
July 2019

A statistical approach to fine-mapping for the identification of potential causal variants related to human intelligence.

J Hum Genet 2019 Aug 5;64(8):781-787. Epub 2019 Jun 5.

Tulane Center for Bioinformatics and Genomics, Department of Global Biostatistics and Data Science, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, 70112, USA.

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http://dx.doi.org/10.1038/s10038-019-0623-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712985PMC
August 2019

Influence of mouse defective zona pellucida in folliculogenesis on apoptosis of granulosa cells and developmental competence of oocytes†.

Biol Reprod 2019 08;101(2):457-465

Institute of Reproductive and Stem Cell Engineering, School of Basic Medical Science, Central South University, Changsha, China.

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http://dx.doi.org/10.1093/biolre/ioz093DOI Listing
August 2019

Causal Effects of Genetically Predicted Cardiovascular Risk Factors on Chronic Kidney Disease: A Two-Sample Mendelian Randomization Study.

Front Genet 2019 3;10:415. Epub 2019 May 3.

Center of System Biology and Data Information, School of Basic Medical Science, Central South University, Changsha, China.

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http://dx.doi.org/10.3389/fgene.2019.00415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509563PMC
May 2019

Gene shaving using a sensitivity analysis of kernel based machine learning approach, with applications to cancer data.

PLoS One 2019 23;14(5):e0217027. Epub 2019 May 23.

Tulane Center of Bioinformatics and Genomics, Department of Global Biostatistics and Data Science, Tulane University, New Orleans, LA 70112, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0217027PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532884PMC
February 2020

Examining the causal role of leptin in bone mineral density: A Mendelian randomization study.

Bone 2019 08 8;125:25-29. Epub 2019 May 8.

Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, China; Center of Bioinformatics and Genomics, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA; School of Basic Medical Science, National Clinical Research Center for Geriatric Diseases, Xiangya Hospital, Central South University, Changsha, Hunan 410013, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S87563282193017
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http://dx.doi.org/10.1016/j.bone.2019.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686663PMC
August 2019

Long Noncoding RNA Analyses for Osteoporosis Risk in Caucasian Women.

Calcif Tissue Int 2019 08 9;105(2):183-192. Epub 2019 May 9.

Center of Genomics and Bioinformatics, Tulane University, New Orleans, LA, 70112, USA.

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http://dx.doi.org/10.1007/s00223-019-00555-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712977PMC
August 2019

Genetic risk factors identified in populations of European descent do not improve the prediction of osteoporotic fracture and bone mineral density in Chinese populations.

Sci Rep 2019 04 15;9(1):6086. Epub 2019 Apr 15.

Center for Bioinformatics and Genomics, Department of Global Biostatistics and Data Science, Tulane University, New Orleans, LA, 70112, USA.

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http://dx.doi.org/10.1038/s41598-019-42606-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465274PMC
April 2019

Identification of a 1p21 independent functional variant for abdominal obesity.

Int J Obes (Lond) 2019 12 3;43(12):2480-2490. Epub 2019 Apr 3.

Center for Genetic Epidemiology and Genomics, School of Public Health, Medical College of Soochow University, Suzhou, China.

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http://dx.doi.org/10.1038/s41366-019-0350-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776704PMC
December 2019

Identification of novel genetic variants for type 2 diabetes, childhood obesity, and their pleiotropic loci.

J Hum Genet 2019 May 28;64(5):369-377. Epub 2019 Feb 28.

Center for Bioinformatics and Genomics, Department of Biostatistics and Data Science, Tulane University, New Orleans, LA, USA.

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http://dx.doi.org/10.1038/s10038-019-0577-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712986PMC
May 2019

Identify gene expression pattern change at transcriptional and post-transcriptional levels.

Transcription 2019 06 5;10(3):137-146. Epub 2019 Feb 5.

a Center of Bioinformatics and Genomics, Department of Global Biostatistics and Data Science , Tulane University , New Orleans , LA , USA.

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http://dx.doi.org/10.1080/21541264.2019.1575159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6602563PMC
June 2019

The good, the bad, and the ugly of calcium supplementation: a review of calcium intake on human health.

Clin Interv Aging 2018 28;13:2443-2452. Epub 2018 Nov 28.

Center for Bioinformatics and Genomics, Department of Global Biostatistics and Data Science, Tulane University, New Orleans, LA 70112, USA,

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https://www.dovepress.com/the-good-the-bad-and-the-ugly-of-c
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http://dx.doi.org/10.2147/CIA.S157523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276611PMC
February 2019

A joint analysis of metabolomic profiles associated with muscle mass and strength in Caucasian women.

Aging (Albany NY) 2018 10;10(10):2624-2635

Tulane Center of Bioinformatics and Genomics, Department of Global Biostatistics and Data Science, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA.

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http://dx.doi.org/10.18632/aging.101574DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224264PMC
October 2018

Assessing the Genetic Correlations Between Blood Plasma Proteins and Osteoporosis: A Polygenic Risk Score Analysis.

Calcif Tissue Int 2019 02 10;104(2):171-181. Epub 2018 Oct 10.

School of Basic Medical Sciences, Central South University, 410000, Changsha, People's Republic of China.

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http://dx.doi.org/10.1007/s00223-018-0483-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368453PMC
February 2019

Additional common variants associated with type 2 diabetes and coronary artery disease detected using a pleiotropic cFDR method.

J Diabetes Complications 2018 Dec 9;32(12):1105-1112. Epub 2018 Sep 9.

College of Public Health, Zhengzhou University, Zhengzhou, No. 100 Kexue Road, High-Tech Development Zone Of States, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.jdiacomp.2018.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743331PMC
December 2018

Epigenetically Silenced Candidate Tumor Suppressor Genes in Prostate Cancer: Identified by Modeling Methylation Stratification and Applied to Progression Prediction.

Cancer Epidemiol Biomarkers Prev 2019 01 27;28(1):198-207. Epub 2018 Sep 27.

Department of Computer Science, Bioinformatics Facility of Xavier NIH RCMI Cancer Research Center, Xavier University of Louisiana, New Orleans, Louisiana.

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http://dx.doi.org/10.1158/1055-9965.EPI-18-0491DOI Listing
January 2019

Identification of potential functional genes in papillary thyroid cancer by co-expression network analysis.

Oncol Lett 2018 Oct 14;16(4):4871-4878. Epub 2018 Aug 14.

Department of Endocrinology and Metabolism, The Third Affiliated Hospital, Southern Medical University, Guangzhou, Guangdong 510630, P.R. China.

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http://dx.doi.org/10.3892/ol.2018.9306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6144229PMC
October 2018

Age at menarche and osteoporosis: A Mendelian randomization study.

Bone 2018 12 18;117:91-97. Epub 2018 Sep 18.

Center for Bioinformatics and Genomics, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S87563282183035
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http://dx.doi.org/10.1016/j.bone.2018.09.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346741PMC
December 2018

Assessing the genetic correlations between early growth parameters and bone mineral density: A polygenic risk score analysis.

Bone 2018 11 30;116:301-306. Epub 2018 Aug 30.

Center for Bioinformatics and Genomics, Department of Global Biostatistics and Data Science, School of Public Health and Tropical Medicine, Tulane University, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bone.2018.08.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298225PMC
November 2018

Identification of novel variants associated with osteoporosis, type 2 diabetes and potentially pleiotropic loci using pleiotropic cFDR method.

Bone 2018 12 30;117:6-14. Epub 2018 Aug 30.

Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, China; School of Basic Medical Sciences, Central South University, Changsha, Hunan 410013, China; Center of Bioinformatics and Genomics, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S87563282183032
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http://dx.doi.org/10.1016/j.bone.2018.08.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364698PMC
December 2018

PCA-based GRS analysis enhances the effectiveness for genetic correlation detection.

Brief Bioinform 2019 11;20(6):2291-2298

Center for Bioinformatics and Genomics, Department of Global Biostatistics and Data Science, School of Public Health and Tropical Medicine, Tulane University, China.

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http://dx.doi.org/10.1093/bib/bby075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954421PMC
November 2019

Metabolomic profiles associated with bone mineral density in US Caucasian women.

Nutr Metab (Lond) 2018 10;15:57. Epub 2018 Aug 10.

2Tulane Center of Bioinformatics and Genomics, Department of Global Biostatistics and Data Science, Tulane University School of Public Health and Tropical Medicine, 1440 Canal St., RM 1619F, New Orleans, LA 70112 USA.

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http://dx.doi.org/10.1186/s12986-018-0296-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086033PMC
August 2018

Transcriptomic Data Identified Key Transcription Factors for Osteoporosis in Caucasian Women.

Calcif Tissue Int 2018 12 28;103(6):581-588. Epub 2018 Jul 28.

Center of Genomics and Bioinformatics, Tulane University, New Orleans, LA, 70112, USA.

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http://dx.doi.org/10.1007/s00223-018-0457-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343666PMC
December 2018

Genetically driven adiposity traits increase the risk of coronary artery disease independent of blood pressure, dyslipidaemia, glycaemic traits.

Eur J Hum Genet 2018 10 11;26(10):1547-1553. Epub 2018 Jun 11.

College of Public Health, Zhengzhou University, Zhengzhou, NO.100 Kexue Road, High-Tech Development Zone of States, People's Republic of China.

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http://dx.doi.org/10.1038/s41431-018-0180-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138729PMC
October 2018

Integration of summary data from GWAS and eQTL studies identified novel causal BMD genes with functional predictions.

Bone 2018 08 12;113:41-48. Epub 2018 May 12.

Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, China; Center of Bioinformatics and Genomics, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA; Institute of Reproduction and Stem Cell Engineering, School of Basic Medical Science, Central South University, Changsha, Hunan 410013, China. Electronic address:

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http://dx.doi.org/10.1016/j.bone.2018.05.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346739PMC
August 2018

Detecting epistasis within chromatin regulatory circuitry reveals CAND2 as a novel susceptibility gene for obesity.

Int J Obes (Lond) 2019 03 1;43(3):450-456. Epub 2018 May 1.

Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, People's Republic of China.

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http://dx.doi.org/10.1038/s41366-018-0069-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298858PMC
March 2019

Genome-wide association study of lncRNA polymorphisms with bone mineral density.

Ann Hum Genet 2018 09 16;82(5):244-253. Epub 2018 Apr 16.

Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China.

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http://dx.doi.org/10.1111/ahg.12247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298226PMC
September 2018

Assessing the Associations of Blood Metabolites With Osteoporosis: A Mendelian Randomization Study.

J Clin Endocrinol Metab 2018 05;103(5):1850-1855

Center for Bioinformatics and Genomics, Department of Global Biostatistics and Data Science, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana.

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http://dx.doi.org/10.1210/jc.2017-01719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456956PMC
May 2018

Joint study of two genome-wide association meta-analyses identified 20p12.1 and 20q13.33 for bone mineral density.

Bone 2018 05 28;110:378-385. Epub 2018 Feb 28.

Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Medical College of Soochow University, Jiangsu, PR China; Center for Genetic Epidemiology and Genomics, School of Public Health, Medical College of Soochow University, Jiangsu, PR China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S87563282183008
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http://dx.doi.org/10.1016/j.bone.2018.02.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329308PMC
May 2018

Inferring causal relationships between phenotypes using summary statistics from genome-wide association studies.

Hum Genet 2018 Mar 19;137(3):247-255. Epub 2018 Feb 19.

Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, 410081, Hunan, China.

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http://dx.doi.org/10.1007/s00439-018-1876-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343668PMC
March 2018

EPS-LASSO: test for high-dimensional regression under extreme phenotype sampling of continuous traits.

Bioinformatics 2018 06;34(12):1996-2003

Center of Bioinformatics and Genomics, Tulane University, New Orleans, LA, USA.

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http://dx.doi.org/10.1093/bioinformatics/bty042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454442PMC
June 2018

A novel approach for correction of crosstalk effects in pathway analysis and its application in osteoporosis research.

Sci Rep 2018 01 12;8(1):668. Epub 2018 Jan 12.

Center of Genomics and Bioinformatics, Tulane University, New Orleans, LA, 70112, USA.

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http://dx.doi.org/10.1038/s41598-018-19196-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766601PMC
January 2018

Identifying potentially common genes between dyslipidemia and osteoporosis using novel analytical approaches.

Mol Genet Genomics 2018 Jun 11;293(3):711-723. Epub 2018 Jan 11.

Center for Bioinformatics and Genomics, Department of Global Statistics and Data Science, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, 70112, USA.

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http://dx.doi.org/10.1007/s00438-017-1414-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949092PMC
June 2018

Novel Common Variants Associated with Obesity and Type 2 Diabetes Detected Using a cFDR Method.

Sci Rep 2017 11 27;7(1):16397. Epub 2017 Nov 27.

College of Public Health, Zhengzhou University, Zhengzhou, NO.100 Kexue Road, High-Tech Development Zone Of States, Zhengzhou, P.R. China.

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http://dx.doi.org/10.1038/s41598-017-16722-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703959PMC
November 2017

Identification of Novel Potentially Pleiotropic Variants Associated With Osteoporosis and Obesity Using the cFDR Method.

J Clin Endocrinol Metab 2018 01;103(1):125-138

Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China.

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http://dx.doi.org/10.1210/jc.2017-01531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061219PMC
January 2018

Improved detection of genetic loci in estimated glomerular filtration rate and type 2 diabetes using a pleiotropic cFDR method.

Mol Genet Genomics 2018 Feb 16;293(1):225-235. Epub 2017 Oct 16.

College of Public Health Zhengzhou University, No.100 Kexue Road, High-Tech Development Zone of States, Zhengzhou, People's Republic of China.

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http://dx.doi.org/10.1007/s00438-017-1381-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819009PMC
February 2018

Association Between Gut Microbiota and Bone Health: Potential Mechanisms and Prospective.

J Clin Endocrinol Metab 2017 10;102(10):3635-3646

Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, PR China.

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http://dx.doi.org/10.1210/jc.2017-00513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630250PMC
October 2017

Linking Alzheimer's disease and type 2 diabetes: Novel shared susceptibility genes detected by cFDR approach.

J Neurol Sci 2017 Sep 1;380:262-272. Epub 2017 Aug 1.

Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, PR China; Center for Bioinformatics and Genomics, Department of Global Biostatistics and Data Science, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jns.2017.07.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6693589PMC
September 2017

Novel common variants associated with body mass index and coronary artery disease detected using a pleiotropic cFDR method.

J Mol Cell Cardiol 2017 11 24;112:1-7. Epub 2017 Aug 24.

College of Public Health, Zhengzhou University, No.100 Kexue Road, High-Tech Development Zone of States, Zhengzhou, People's Republic of China; Center for Genomics and Bioinformatics, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2017.08.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5812278PMC
November 2017

Enhanced Identification of Potential Pleiotropic Genetic Variants for Bone Mineral Density and Breast Cancer.

Calcif Tissue Int 2017 11 31;101(5):489-500. Epub 2017 Jul 31.

Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Southern Medical University, Guangzhou, 510630, People's Republic of China.

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http://dx.doi.org/10.1007/s00223-017-0308-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796546PMC
November 2017

Genetic sharing with coronary artery disease identifies potential novel loci for bone mineral density.

Bone 2017 Oct 23;103:70-77. Epub 2017 Jun 23.

Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China; Center for Bioinformatics and Genomics, Department of Global Biostatistics and Data Science, Tulane University, New Orleans, LA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bone.2017.06.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796548PMC
October 2017

Regulatory element-based prediction identifies new susceptibility regulatory variants for osteoporosis.

Hum Genet 2017 08 20;136(8):963-974. Epub 2017 Jun 20.

Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi, 710049, People's Republic of China.

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http://dx.doi.org/10.1007/s00439-017-1825-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550554PMC
August 2017

Multiple analyses indicate the specific association of NR1I3, C6 and TNN with low hip BMD risk.

J Genet Genomics 2017 06 8;44(6):327-330. Epub 2017 May 8.

Center of System Biomedical Sciences, University of Shanghai for Science and Technology, Shanghai 200093, China; Center for Bioinformatics and Genomics, Department of Global Biostatistics and Data Science, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jgg.2017.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5822710PMC
June 2017

Corrigendum to "Quantitative proteomics and integrative network analysis identified novel genes and pathways related to osteoporosis" [J. Proteomics 142 (16 June 2016) 45-52].

J Proteomics 2017 06;162:155

College of Life Sciences and Bioengineering, Beijing Jiao Tong University, Beijing 100044, China; Center for Bioinformatics and Genomics, Department of Biostatistics and Bioinformatics, Tulane University, New Orleans 70112, LA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jprot.2017.05.023DOI Listing
June 2017

A Systemic Analysis of Transcriptomic and Epigenomic Data To Reveal Regulation Patterns for Complex Disease.

G3 (Bethesda) 2017 07 5;7(7):2271-2279. Epub 2017 Jul 5.

Center of Genomics and Bioinformatics, Department of Global Biostatistics and Data Science, Tulane University, New Orleans, Louisiana 70112

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http://dx.doi.org/10.1534/g3.117.042408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499134PMC
July 2017

A Systems Genetics Approach Identified GPD1L and its Molecular Mechanism for Obesity in Human Adipose Tissue.

Sci Rep 2017 05 11;7(1):1799. Epub 2017 May 11.

Center for Bioinformatics and Genomics, Department of Biostatistics and Bioinformatics, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, 70112, USA.

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http://dx.doi.org/10.1038/s41598-017-01517-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431993PMC
May 2017

A Statistical Approach to Fine Mapping for the Identification of Potential Causal Variants Related to Bone Mineral Density.

J Bone Miner Res 2017 Aug 22;32(8):1651-1658. Epub 2017 May 22.

Center for Bioinformatics and Genomics, Department of Global Biostatistics and Data Science, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.

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http://dx.doi.org/10.1002/jbmr.3154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550336PMC
August 2017

Systemic analysis of osteoblast-specific DNA methylation marks reveals novel epigenetic basis of osteoblast differentiation.

Bone Rep 2017 Jun 3;6:109-119. Epub 2017 Apr 3.

Center for Bioinformatics and Genomics, Department of Global Biostatistics and Data Science, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA.

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http://dx.doi.org/10.1016/j.bonr.2017.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384298PMC
June 2017

An adaptive strategy for association analysis of common or rare variants using entropy theory.

J Hum Genet 2017 Aug 6;62(8):777-781. Epub 2017 Apr 6.

Center for Bioinformatics and Genomics, Department of Global Biostatistics and Data Science, Tulane University, New Orleans, LA, USA.

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http://dx.doi.org/10.1038/jhg.2017.39DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584517PMC
August 2017

Increased detection of genetic loci associated with risk predictors of osteoporotic fracture using a pleiotropic cFDR method.

Bone 2017 06 31;99:62-68. Epub 2017 Mar 31.

Center for Bioinformatics and Genomics, Department of Biostatistics and Bioinformatics, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bone.2017.03.052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488332PMC
June 2017

Functional relevance for associations between osteoporosis and genetic variants.

PLoS One 2017 3;12(4):e0174808. Epub 2017 Apr 3.

Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0174808PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378394PMC
August 2017

Gene-based genome-wide association study identified 19p13.3 for lean body mass.

Sci Rep 2017 03 21;7:45025. Epub 2017 Mar 21.

Center of System Biomedical Sciences, University of Shanghai for Science and Technology, Shanghai, PR China.

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http://dx.doi.org/10.1038/srep45025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359571PMC
March 2017

SNP-SNP interactions between WNT4 and WNT5A were associated with obesity related traits in Han Chinese Population.

Sci Rep 2017 03 8;7:43939. Epub 2017 Mar 8.

Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, P. R. China.

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http://dx.doi.org/10.1038/srep43939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341019PMC
March 2017

Comparison of statistical methods for subnetwork detection in the integration of gene expression and protein interaction network.

BMC Bioinformatics 2017 Mar 3;18(1):149. Epub 2017 Mar 3.

Department of Biostatistics and Bioinformatics, Center for Bioinformatics and Genomics, Tulane University School of Public Health and Tropical Medicine, 1440 Canal St., Suite 2001, New Orleans, LA, 70112, USA.

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http://dx.doi.org/10.1186/s12859-017-1567-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5335754PMC
March 2017

Genomic variants at 20p11 associated with body fat mass in the European population.

Obesity (Silver Spring) 2017 04 22;25(4):757-764. Epub 2017 Feb 22.

Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, Suzhou, PR China.

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http://dx.doi.org/10.1002/oby.21775DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373963PMC
April 2017

Bivariate genome-wide association analyses identified genetic pleiotropic effects for bone mineral density and alcohol drinking in Caucasians.

J Bone Miner Metab 2017 Nov 23;35(6):649-658. Epub 2016 Dec 23.

Key Lab of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences, Hunan Normal University, Changsha, China.

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https://pdfs.semanticscholar.org/4261/e4a43ad34587861e337385
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http://dx.doi.org/10.1007/s00774-016-0802-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5812284PMC
November 2017

Replication of Caucasian Loci Associated with Osteoporosis-related Traits in East Asians.

J Bone Metab 2016 Nov 30;23(4):233-242. Epub 2016 Nov 30.

Division of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.11005/jbm.2016.23.4.233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5153380PMC
November 2016

Increased identification of novel variants in type 2 diabetes, birth weight and their pleiotropic loci.

J Diabetes 2017 Oct 20;9(10):898-907. Epub 2017 Jan 20.

Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.

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http://dx.doi.org/10.1111/1753-0407.12510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841537PMC
October 2017

Mass spectrometry based proteomics profiling of human monocytes.

Protein Cell 2017 02 22;8(2):123-133. Epub 2016 Nov 22.

College of Life Sciences and Bioengineering, Beijing Jiaotong University, Beijing, 100044, China.

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http://dx.doi.org/10.1007/s13238-016-0342-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291777PMC
February 2017

Corrigendum to genome-wide association study in East Asians suggests UHMK1 as a novel bone mineral density susceptibility gene.

Bone 2018 01 17;106:211. Epub 2016 Nov 17.

Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.bone.2016.11.015DOI Listing
January 2018

Composition of gut microbiota in infants in China and global comparison.

Sci Rep 2016 11 9;6:36666. Epub 2016 Nov 9.

Division of Birth Cohort Study, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, People's Republic of China.

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http://dx.doi.org/10.1038/srep36666DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101483PMC
November 2016

Low-, high-coverage, and two-stage DNA sequencing in the design of the genetic association study.

Genet Epidemiol 2017 04 4;41(3):187-197. Epub 2016 Nov 4.

Department of Biostatistics and Bioinformatics, Center for Bioinformatics and Genomics, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA.

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http://dx.doi.org/10.1002/gepi.22015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363279PMC
April 2017

Tissue-specific pathway association analysis using genome-wide association study summaries.

Bioinformatics 2017 01 20;33(2):243-247. Epub 2016 Sep 20.

Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, School of Public Health, Health Science Center.

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https://academic.oup.com/bioinformatics/article-lookup/doi/1
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http://dx.doi.org/10.1093/bioinformatics/btw595DOI Listing
January 2017

A bivariate genome-wide association study identifies ADAM12 as a novel susceptibility gene for Kashin-Beck disease.

Sci Rep 2016 08 22;6:31792. Epub 2016 Aug 22.

Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, School of Public Health, Health Science center, Xi'an Jiaotong University, Xi'an, P. R. China.

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http://www.nature.com/articles/srep31792
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http://dx.doi.org/10.1038/srep31792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992896PMC
August 2016

Integrating Epigenomic Elements and GWASs Identifies BDNF Gene Affecting Bone Mineral Density and Osteoporotic Fracture Risk.

Sci Rep 2016 07 28;6:30558. Epub 2016 Jul 28.

Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, P. R. China.

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http://dx.doi.org/10.1038/srep30558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964617PMC
July 2016

Genome-wide association study in East Asians suggests UHMK1 as a novel bone mineral density susceptibility gene.

Bone 2016 10 15;91:113-21. Epub 2016 Jul 15.

Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S87563282163018
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http://dx.doi.org/10.1016/j.bone.2016.07.008DOI Listing
October 2016

Genome-wide association meta-analyses identified 1q43 and 2q32.2 for hip Ward's triangle areal bone mineral density.

Bone 2016 10 7;91:1-10. Epub 2016 Jul 7.

Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Medical College of Soochow University, Jiangsu, PR China; Center for Genetic Epidemiology and Genomics, School of Public Health, Medical College of Soochow University, Jiangsu, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.bone.2016.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362380PMC
October 2016

A systematic review of association studies of common variants associated with idiopathic congenital talipes equinovarus (ICTEV) in humans in the past 30 years.

Springerplus 2016 27;5(1):896. Epub 2016 Jun 27.

Department of Pediatric Orthopedics, Guang Zhou Women and Children's Medical Center, Sun Yat-Sen University, 9th Floor, No 9., Jingsui Road, Guangzhou, China.

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http://dx.doi.org/10.1186/s40064-016-2353-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4923008PMC
July 2016