Publications by authors named "Hong-Uyen Hua"

9 Publications

  • Page 1 of 1

Vitreous Hemorrhage in Type 3 Gaucher Disease: An Angiographic and Pathologic Analysis.

Retin Cases Brief Rep 2020 Sep 28. Epub 2020 Sep 28.

The Vision Center, Department of Surgery, Children's Hospital Los Angeles, Los Angeles, CA, USA.

Purpose: To describe the case of a 12-year-old female with vitreoretinal manifestations of Type 3 Gaucher disease.

Methods: Retrospective case report including multimodal imaging and histologic examination of the vitreous.

Results: A 12-year-old female with a history of Gaucher disease Type 3 was referred to the ophthalmology service for evaluation of vitreous deposits in both eyes. Funduscopic examination was notable for white vitreous opacities in both eyes. Ultra-widefield fluorescein angiography demonstrated areas of blockage associated with the deposits as well as focal areas of leakage. OCT angiography showed shadow artifact without intrinsic flow at these sites. Three years after presentation, she developed a right hemorrhagic posterior vitreous detachment, requiring pars plana vitrectomy with scleral buckle. A vitreous sample was sent to pathology, which demonstrated Gaucher cells.

Discussion: Gaucher disease is a rare metabolic condition caused by an autosomal recessive deficiency of glucocerebrosidase. To our knowledge, this is the first report of hemorrhagic posterior vitreous detachment in Type 3 Gaucher disease, including ultra-widefield imaging, OCT angiography, and histopathology.
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http://dx.doi.org/10.1097/ICB.0000000000001064DOI Listing
September 2020

Understanding seizure risk with wide field fundus photography: Implications for screening guidelines in the era of COVID-19 and telemedicine.

Am J Ophthalmol Case Rep 2020 Sep 5;19:100844. Epub 2020 Aug 5.

California Retina Consultants and Research Foundation, Santa Barbara, CA, USA.

Purpose: To report two cases of photosensitive seizures due to fundus photography flash.

Observations: Two patients with seizure history present to a retina clinic for routine follow up. While obtaining imaging, these patients experienced a seizure triggered by fundus camera flash.

Conclusions: Fundus photography is essential and ubiquitous amongst optometry and ophthalmology practices, especially in the rising era of telemedicine in the setting of the recent COVID-19 pandemic. To our knowledge, there are no other reports in the literature of seizures triggered by fundus photography flash. However, we believe this to be an under-reported phenomenon and suggest that all eye care providers screen patients for a history of seizures or epilepsy prior to fundus photography.
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http://dx.doi.org/10.1016/j.ajoc.2020.100844DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7405818PMC
September 2020

Teleophthalmology: an essential tool in the era of the novel coronavirus 2019.

Curr Opin Ophthalmol 2020 Sep;31(5):366-373

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida.

Purpose Of Review: The aim of this article is to assess the current state of teleophthalmology given the sudden surge in telemedicine demand in response to the novel coronavirus 2019 (COVID-19).

Recent Findings: Recommendations and policies from government and national health organizations, combined with social distancing, have led to exponential increases in telemedicine use. Teleophthalmology can be integrated into ophthalmic care delivery. In the emergency room, teleophthalmology can be utilized to triage patients and diagnose common ophthalmic eye diseases. Ophthalmology practices can utilize real-time medicine to conduct many parts of an in-person exam. In cases where more complex diagnostic tools are warranted, a model incorporating telemedicine and focused in-person visits may still be beneficial. Innovative technologies emerging in the market allow for increased remote monitoring, screening, and management of adult and pediatric patients for common eye diseases.

Summary: COVID-19 created a demand for healthcare delivery that limits in-person examination and potential viral exposure. Teleophthalmology allows ophthalmologists to continue caring for patients while keeping physicians and patients safe. Although challenges still exist, the pandemic has accelerated the adoption of teleophthalmology. As a result, teleophthalmology will play an integral role in providing high-quality efficient care in the near future.
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http://dx.doi.org/10.1097/ICU.0000000000000689DOI Listing
September 2020

Acute Promyelocytic Leukemia With Sudden Vision Loss.

JAMA Ophthalmol 2020 02;138(2):206-207

Los Angeles County and University of Southern California Medical Center, University of Southern California Roski Eye Insitute, Department of Ophthalmology, University of Southern California, Los Angeles.

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http://dx.doi.org/10.1001/jamaophthalmol.2019.4838DOI Listing
February 2020

Dry Eye Symptoms and Ocular Pain in Veterans with Glaucoma.

J Clin Med 2019 Jul 22;8(7). Epub 2019 Jul 22.

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 900 NW 17th Street, Miami, FL 33136, USA.

Dry eye and glaucoma are two frequently encountered ocular conditions, which can lead to substantial morbidity and decreased quality of life. Patients on topical glaucoma medications are known to be at greater risk for ocular surface symptoms. Veterans seen in the eye clinics at the Miami Veterans Affairs Hospital from January to July 2016 completed surveys assessing dry eye and ocular pain symptoms, including the five item Dry Eye Questionnaire (DEQ5). A total of 62 patients with glaucoma completed the survey. Of those, 52 were on glaucoma medications at the time of the survey, with the majority requiring more than one medication to control intraocular pressure. The frequency of mild or greater dry eye symptoms (defined as DEQ5 >6) tended to increase with increasing medication burden, and patients on brimonidine were more likely to report a DEQ5 >6. Patients on three or more glaucoma medications were more likely to report symptoms of shooting pain, dryness, and itchiness. Patients using timolol were more likely to report throbbing and pain by light, while those on latanoprost reported stinging. Our data support an association between increasing number of glaucoma medications and worsening of dry eye symptoms. Patient and medication-associated symptoms can be used to tailor individual medication regimens.
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http://dx.doi.org/10.3390/jcm8071076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678384PMC
July 2019

Avascular Retinal Findings in a Child With Achondroplasia.

Ophthalmic Surg Lasers Imaging Retina 2017 03;48(3):272-274

The authors present clinical and angiographic findings in a 12-year-old girl with achondroplasia who presented with bilateral retinal peripheral nonperfusion and unilateral rhegmatogenous retinal detachment, which has not been previously described in achondroplasia. This report contributes incremental knowledge regarding aberrant retinal vascular phenomena observed in pediatric disease states and implicates the possible role of mutations in the FGFR3 gene in peripheral vascular abnormalities. [Ophthalmic Surg Lasers Imaging Retina. 2017;48:272-274.].
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http://dx.doi.org/10.3928/23258160-20170301-14DOI Listing
March 2017

Hospital survival of aortic dissection in children.

J Surg Res 2015 Jun 18;196(2):399-403. Epub 2015 Mar 18.

Division of Pediatric Surgery, DeWitt-Daughtry Family Department of Surgery, Leonard M. Miller School of Medicine, University of Miami, Miami, Florida.

Background: Thoracic aortic dissection (AD) is a rare occurrence in childhood and mostly associated with connective tissue disorders or congenital abnormalities. We examined the characteristics associated with AD and predictors of survival.

Methods: The Kids' Inpatient Database (1997-2009) was used to identify thoracic ADs occurring in patients <20-y-old. Clinical characteristics, as well as determinants of survival, were analyzed using standard statistical methods.

Results: One hundred sixty-eight cases of thoracic AD were identified during the study period. Overall survival was 83%. Average length of stay was 15.9 ± 16.9 d, with charges 181,867.92 ± $211,985.00. Thoracic dissection tended to affect adolescents aged 15-19 y (67%), males (76%), and Caucasians (56%) most frequently. Most patients were privately insured (64%) and treated at urban teaching centers (86%). Commonly associated diagnoses were hypertension (18%), Marfan syndrome (15%), and aortic valve disorders (8%). When repair was performed, open repair was more frequent (88%) than endovascular repair (6%). Hemorrhage was the most common complication (19%). Multiple determinants of survival were found. Girls (mortality odds ratio: 0.21 [0.05-0.91]) fared better than boys, P = 0.023. Patients with Medicaid (2.84 [1.21-6.69]) had higher mortality versus privately insured, P = 0.014. Income, race, and hospital characteristics, and type of repair were not significant predictors, even on sub-analyses of surgical and nonsurgical groups separately.

Conclusions: Dissection of the thoracic aorta is a rare but significant condition affecting the pediatric population. Most repairs are performed using open technique. Payer status and gender are predictors of survival in these cases.
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http://dx.doi.org/10.1016/j.jss.2015.03.030DOI Listing
June 2015

Stool phospholipid signature is altered by diet and tumors.

PLoS One 2014 3;9(12):e114352. Epub 2014 Dec 3.

Division of Gastroenterology, Department of Medicine, Miller School of Medicine, University of Miami, Miami, Florida, United States of America.

Intake of saturated fat is a risk factor for ulcerative colitis (UC) and colon cancer. Changes in the microbiota have been implicated in the development of UC and colon cancer. The host and the microbiota generate metabolites that may contribute to or reflect disease pathogenesis. We used lipid class specific quantitative mass spectrometry to assess the phospholipid (PL) profile (phosphatidylcholine [PC], phosphatidylethanolamine [PE], phosphatidylinositol [PI], phosphatidylserine [PS]) of stool from mice fed a high fat (HFD) or control diet with or without induction of colitis-associated tumors using azoxymethane and dextran sodium sulfate. The microbiota was assessed using qPCR for several bacterial groups. Colitis-associated tumors were associated with reduced bulk PI and PE levels in control diet fed mice compared to untreated mice. Significant decreases in the relative quantities of several PC species were found in colitis-associated tumor bearing mice fed either diet. Statistical analysis of the PL profile revealed distinct clustering by treatment group. Partial least squares regression analysis found that the relative quantities of the PS class profile best predicted bacterial abundance of Clostridium leptum and Prevotella groups. Abundance of selected PL species correlated with bacterial group quantities. Thus, we have described that a HFD and colitis-associated tumors are associated with changes in phospholipids and may reflect host-microbial interactions and disease states.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0114352PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254978PMC
December 2015

Mass spectrometric analyses of phosphatidylcholines in alkali-exposed corneal tissue.

Invest Ophthalmol Vis Sci 2012 Oct 23;53(11):7122-30. Epub 2012 Oct 23.

Bascom Palmer Eye Institute, University of Miami, Miami, Florida, USA.

Purpose: The aims were to determine whether exposure to sodium hydroxide results in predictable changes in phosphatidylcholine (PC) in corneal tissue and if PC profile changes correlate to exposure duration. PCs are major components of the cell membrane lipid bilayer and are often involved in biological processes such as signaling.

Methods: Enucleated porcine (n = 140) and cadaver human eyes (n = 20) were exposed to water (control) and 11 M NaOH. The corneas were excised and lipids were extracted using the Bligh and Dyer method with suitable modifications. Class-specific lipid identification was carried out using a ratiometric lipid standard on a TSQ Quantum Access Max mass spectrometer. Protein amounts were determined using Bradford assays.

Results: Control and alkali-treated corneas showed reproducible PC spectra for both porcine and human corneas. Over 200 PCs were identified for human and porcine control and each experimental time point. Several PC species (m/z values) consequent upon alkali exposure could not be ascribed to a recorded PC species. Control and treated groups showed 41 and 29 common species among them for porcine and human corneas, respectively. The unique PC species peaked at 12 minutes and at 30 minutes for human and porcine corneas followed by a decline consistent with an interplay of alkali penetration and hydrolyses at various time points.

Conclusions: Alkali exposure dramatically changes the PC profile of cornea. Our data are consistent with penetration and hydrolysis as stochastic contributors to changes in PCs due to exposure to alkali for a finite duration and amount.
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http://dx.doi.org/10.1167/iovs.12-10448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487488PMC
October 2012