Hong-Min Liu

Hong-Min Liu

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Hong-Min Liu

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Expression of programmed death ligand 1 (PD-L1) is associated with metastasis and differentiation in gastric cancer.

Life Sci 2020 Feb 31;242:117247. Epub 2019 Dec 31.

Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education of China, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, Henan Province, PR China.. Electronic address:

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http://dx.doi.org/10.1016/j.lfs.2019.117247DOI Listing
February 2020

Palladium-Catalyzed Ligand-Free Double Cyclization Reactions for the Synthesis of 3-(1'-Indolyl)-phthalides.

Org Lett 2020 Feb 14;22(3):814-817. Epub 2020 Jan 14.

School of Pharmaceutical Sciences , Zhengzhou University , Zhengzhou 450001 , China.

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http://dx.doi.org/10.1021/acs.orglett.9b04241DOI Listing
February 2020

Role of drug-metabolizing enzymes in cancer and cancer therapy.

Curr Drug Metab 2020 Jan 2. Epub 2020 Jan 2.

Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China; Co-innovation Center of Henan Province for New Drug R & D and Preclinical Safety; School of Pharmaceutical Sciences; Institute of Drug Discovery and Development, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan 450001, China.

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http://dx.doi.org/10.2174/1389200221666200103111053DOI Listing
January 2020

Novel tertiary sulfonamide derivatives containing benzimidazole moiety as potent anti-gastric cancer agents: Design, synthesis and SAR studies.

Eur J Med Chem 2019 Dec 25;183:111731. Epub 2019 Sep 25.

School of Pharmaceutical Sciences & Collaborative Innovation Center of New Drug Research and Safety Evaluation, Zhengzhou University, Zhengzhou, 450001, China; Key Laboratory of Advanced Drug Preparation Technologies (Ministry of Education), Zhengzhou University, Zhengzhou, 450001, China.

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http://dx.doi.org/10.1016/j.ejmech.2019.111731DOI Listing
December 2019

Novel thiosemicarbazone derivatives containing indole fragment as potent and selective anticancer agent.

Eur J Med Chem 2019 Dec 7;184:111764. Epub 2019 Oct 7.

State Key Laboratory of Esophageal Cancer Prevention and Treatment, Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Co-innovation Center of Henan Province for New Drug R & D and Preclinical Safety, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan, 450001, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2019.111764DOI Listing
December 2019

Corrigendum to "Synthesis and preliminary antiproliferative activity of new pteridin-7(8H)-one derivatives" [Eur. J. Med. Chem. 143 (2018) 1396-1405].

Eur J Med Chem 2019 Nov 31;181:111387. Epub 2019 Jul 31.

Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, PR China; Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education of China, PR China; Key Laboratory of Henan Province for Drug Quality and Evaluation, PR China; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2019.05.077DOI Listing
November 2019

Synthesis and anti-gastric cancer activity evaluation of novel triazole nucleobase analogues containing steroidal/coumarin/quinoline moieties.

Eur J Med Chem 2019 Nov 8;181:111520. Epub 2019 Jul 8.

College of Chemistry and Molecular Engineering, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan, 450001, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2019.07.023DOI Listing
November 2019

Derivative of 5-cyano-6-phenylpyrimidin antagonizes ABCB1- and ABCG2-mediated multidrug resistance.

Eur J Pharmacol 2019 Nov 30;863:172611. Epub 2019 Aug 30.

Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, Queens, NY, 11439, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2019.172611DOI Listing
November 2019

Synthesis and in vitro biological evaluation of novel derivatives of Flexicaulin A condensation with amino acid trifluoroacetate.

Eur J Med Chem 2019 Nov 3;182:111645. Epub 2019 Sep 3.

School of Pharmaceutical Sciences, Institute of Drug Discovery and Development, Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Zhengzhou University, Zhengzhou, 450001, PR China; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, Zhengzhou, 450001, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2019.111645DOI Listing
November 2019

Targeting the DCN1-UBC12 protein-protein interaction: novel approaches and future directions.

Future Med Chem 2019 Nov 31;11(22):2869-2871. Epub 2019 Oct 31.

School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.

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http://dx.doi.org/10.4155/fmc-2019-0253DOI Listing
November 2019

Simultaneous determination of 24 free amino acids in MGC803 cells by hydrophilic interaction liquid chromatography with tandem mass spectrometry.

J Chromatogr B Analyt Technol Biomed Life Sci 2019 Nov 9;1132:121792. Epub 2019 Sep 9.

School of Pharmaceutical Sciences, Institute of Drug Discovery & Development, Zhengzhou University, Zhengzhou 450001, PR China; Key Laboratory of Advanced Drug Preparation Technologies (Zhengzhou University), Ministry of Education, PR China; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, PR China; Key Laboratory of Henan Province for Drug Quality and Evaluation, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.jchromb.2019.121792DOI Listing
November 2019

Identifying the novel inhibitors of lysine-specific demethylase 1 (LSD1) combining pharmacophore-based and structure-based virtual screening.

J Biomol Struct Dyn 2019 Oct 5;37(16):4200-4214. Epub 2018 Dec 5.

Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education of China, Key Laboratory of Henan Province for Drug Quality and Evaluation, School of Pharmaceutical Sciences, Zhengzhou University , Zhengzhou , PR China.

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https://www.tandfonline.com/doi/full/10.1080/07391102.2018.1
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http://dx.doi.org/10.1080/07391102.2018.1538903DOI Listing
October 2019

Epigenetic Modification in Macrophages: A Promising Target for Tumor and Inflammation-associated Disease Therapy.

Curr Top Med Chem 2019 ;19(15):1350-1362

School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China.

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http://dx.doi.org/10.2174/1568026619666190619143706DOI Listing
October 2019

Design, synthesis and biological evaluation of new steroidal β-triazoly enones as potent antiproliferative agents.

Steroids 2019 10 21;150:108431. Epub 2019 Jun 21.

College of Chemistry and Molecular Engineering, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan 450001, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.steroids.2019.108431DOI Listing
October 2019

"On-Water" Palladium-Catalyzed Tandem Cyclization Reaction for the Synthesis of Biologically Relevant 4-Arylquinazolines.

Chemistry 2019 Oct 18;25(57):13109-13113. Epub 2019 Sep 18.

School of Pharmaceutical sciences, Zhengzhou University, Zhengzhou, 450001, P. R. China.

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http://dx.doi.org/10.1002/chem.201903464DOI Listing
October 2019

Probing the binding mechanism of substituted pyridine derivatives as effective and selective lysine-specific demethylase 1 inhibitors using 3D-QSAR, molecular docking and molecular dynamics simulations.

J Biomol Struct Dyn 2019 Aug 5;37(13):3482-3495. Epub 2018 Dec 5.

a Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education of China, Key Laboratory of Henan Province for Drug Quality and Evaluation, School of Pharmaceutical Sciences , Zhengzhou University , Zhengzhou , PR China.

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http://dx.doi.org/10.1080/07391102.2018.1518158DOI Listing
August 2019

Discovery and synthesis of novel indole derivatives-containing 3-methylenedihydrofuran-2(3H)-one as irreversible LSD1 inhibitors.

Eur J Med Chem 2019 Aug 29;175:357-372. Epub 2019 Apr 29.

Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Co-innovation Center of Henan Province for New Drug R & D and Preclinical Safety, School of Pharmaceutical Science, Institute of Drug Discovery and Development, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan, 450001, China. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2019.04.065DOI Listing
August 2019

Discovery of the theobromine derivative MQS-14 that induces death of MGC-803 cells mainly through ROS-mediated mechanisms.

Eur J Med Chem 2019 Jul 17;174:76-86. Epub 2019 Apr 17.

School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2019.04.044DOI Listing
July 2019

IL33 attenuates ventricular remodeling after myocardial infarction through inducing alternatively activated macrophages ethical standards statement.

Eur J Pharmacol 2019 Jul 27;854:307-319. Epub 2019 Apr 27.

Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00142999193028
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http://dx.doi.org/10.1016/j.ejphar.2019.04.046DOI Listing
July 2019

2,4-Disubstituted quinazolines targeting breast cancer cells via EGFR-PI3K.

Eur J Med Chem 2019 Jun 17;172:36-47. Epub 2019 Mar 17.

School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, PR China; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Zhengzhou, 450001, PR China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S02235234193024
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http://dx.doi.org/10.1016/j.ejmech.2019.03.030DOI Listing
June 2019

Sanggenon O induced apoptosis of A549 cells is counterbalanced by protective autophagy.

Bioorg Chem 2019 Jun 4;87:688-698. Epub 2019 Apr 4.

Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, PR China; Key Laboratory of Advanced Drug Preparation Technologies (Zhengzhou University), Ministry of Education of China, PR China; Key Laboratory of Henan Province for Drug Quality and Evaluation, PR China; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2019.03.072DOI Listing
June 2019

Potent 5-Cyano-6-phenyl-pyrimidin-Based Derivatives Targeting DCN1-UBE2M Interaction.

J Med Chem 2019 Jun 3;62(11):5382-5403. Epub 2019 Jun 3.

State Key Laboratory of Esophageal Cancer Prevention and Treatment; Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China; School of Pharmaceutical Sciences , Zhengzhou University , 100 Kexue Avenue , Zhengzhou , Henan 450001 , China.

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http://dx.doi.org/10.1021/acs.jmedchem.9b00003DOI Listing
June 2019

A novel ent-kaurane diterpenoid analog, DN3, selectively kills human gastric cancer cells via acting directly on mitochondria.

Eur J Pharmacol 2019 Apr 16;848:11-22. Epub 2019 Jan 16.

Clinical Pharmacology Laboratory, Zhengzhou University People's Hospital, No. 7, Wei Wu Road, Zhengzhou, Henan, China; Pharmacy Department, Fuwai Centeral China Cardiovascular Hospital, No.1, Fuwai Road, Zhengzhou 451464, Henan, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00142999193002
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http://dx.doi.org/10.1016/j.ejphar.2019.01.013DOI Listing
April 2019

Synthesis, structure-activity relationship studies and biological characterization of new [1,2,4]triazolo[1,5-a]pyrimidine-based LSD1/KDM1A inhibitors.

Eur J Med Chem 2019 Apr 13;167:388-401. Epub 2019 Feb 13.

School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China; Key Laboratory of Advanced Drug Preparation Technologies (Ministry of Education), Zhengzhou University, Zhengzhou, 450001, China; Co-Innovation Center of Henan Province for New Drug R & D and Preclinical Safety, Zhengzhou University, Zhengzhou, 450001, China. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2019.02.039DOI Listing
April 2019

Identification of osimertinib (AZD9291) as a lysine specific demethylase 1 inhibitor.

Bioorg Chem 2019 03 16;84:164-169. Epub 2018 Nov 16.

School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, PR China; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, PR China; Key Laboratory of Technology of Drug Preparation, Ministry of Education of China, Zhengzhou 450001, PR China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00452068183108
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http://dx.doi.org/10.1016/j.bioorg.2018.11.018DOI Listing
March 2019

Experience-based discovery (EBD) of aryl hydrazines as new scaffolds for the development of LSD1/KDM1A inhibitors.

Eur J Med Chem 2019 Mar 2;166:432-444. Epub 2019 Feb 2.

School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China; Key Laboratory of Advanced Drug Preparation Technologies (Ministry of Education), Zhengzhou University, Zhengzhou 450001, China; Co-Innovation Center of Henan Province for New Drug R & D and Preclinical Safety, Zhengzhou University, Zhengzhou 450001, China. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2019.01.075DOI Listing
March 2019

Development of Highly Potent, Selective, and Cellular Active Triazolo[1,5- a]pyrimidine-Based Inhibitors Targeting the DCN1-UBC12 Protein-Protein Interaction.

J Med Chem 2019 03 4;62(5):2772-2797. Epub 2019 Mar 4.

School of Pharmaceutical Sciences and Institute of Drug Discovery & Development , Zhengzhou University , Zhengzhou 450001 , China.

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http://dx.doi.org/10.1021/acs.jmedchem.9b00113DOI Listing
March 2019

Development of formaldehyde dehydrogenase-coupled assay and antibody-based assays for ALKBH5 activity evaluation.

J Pharm Biomed Anal 2019 Jan 7;162:9-15. Epub 2018 Sep 7.

Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Co-innovation Center of Henan Province for New Drug R & D and Preclinical Safety, School of Pharmaceutical Science, Institute of Drug Discovery and Development, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan 450001, China. Electronic address:

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http://dx.doi.org/10.1016/j.jpba.2018.09.018DOI Listing
January 2019

Lysine demethylase 5B (KDM5B): A potential anti-cancer drug target.

Eur J Med Chem 2019 Jan 17;161:131-140. Epub 2018 Oct 17.

Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Co-innovation Center of Henan Province for New Drug R & D and Preclinical Safety, School of Pharmaceutical Sciences, Institute of Drug Discovery and Development, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan, 450001, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S02235234183090
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http://dx.doi.org/10.1016/j.ejmech.2018.10.040DOI Listing
January 2019

Novel 3-(2,6,9-trisubstituted-9H-purine)-8-chalcone derivatives as potent anti-gastric cancer agents: Design, synthesis and structural optimization.

Eur J Med Chem 2019 Jan 25;161:493-505. Epub 2018 Oct 25.

Collaborative Innovation Center of New Drug Research and Safety Evaluation, Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education of China, Key Laboratory of Henan Province for Drug Quality and Evaluation, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan Province, 450001, PR China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S02235234183092
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http://dx.doi.org/10.1016/j.ejmech.2018.10.058DOI Listing
January 2019

Ligand-based design, synthesis and biological evaluation of xanthine derivatives as LSD1/KDM1A inhibitors.

Eur J Med Chem 2019 Jan 17;162:555-567. Epub 2018 Nov 17.

School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China; Co-Innovation Center of Henan Province for New Drug R & D and Preclinical Safety, Zhengzhou 450001, China; Key Laboratory of Advanced Technology of Drug Preparation Technologies (Zhengzhou University), Ministry of Education of China, Zhengzhou 450001, PR China.

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http://dx.doi.org/10.1016/j.ejmech.2018.11.035DOI Listing
January 2019

Early emergence of OXA-181-producing Escherichia coli ST410 in China.

J Glob Antimicrob Resist 2018 12 3;15:215-218. Epub 2018 Jul 3.

School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, China; Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, Zhengzhou, Henan 450001, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22137165183012
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http://dx.doi.org/10.1016/j.jgar.2018.06.017DOI Listing
December 2018

Discovery of a non-toxic [1,2,4]triazolo[1,5-a]pyrimidin-7-one (WS-10) that modulates ABCB1-mediated multidrug resistance (MDR).

Bioorg Med Chem 2018 12 3;26(22):5974-5985. Epub 2018 Nov 3.

School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China; Co-Innovation Center of Henan Province for New Drug R & D and Preclinical Safety, Zhengzhou 450001, China; Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education of China, Zhengzhou 450001, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09680896183182
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http://dx.doi.org/10.1016/j.bmc.2018.10.027DOI Listing
December 2018

Probing the binding mode and unbinding mechanism of LSD1 inhibitors by combined computational methods.

Phys Chem Chem Phys 2018 Dec;20(47):29833-29846

Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education of China, Key Laboratory of Henan Province for Drug Quality and Evaluation, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, P. R. China.

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http://dx.doi.org/10.1039/c8cp03090aDOI Listing
December 2018

FLI-06 suppresses proliferation, induces apoptosis and cell cycle arrest by targeting LSD1 and Notch pathway in esophageal squamous cell carcinoma cells.

Biomed Pharmacother 2018 Nov 31;107:1370-1376. Epub 2018 Aug 31.

School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China; Co-Innovation Center of Henan Province for New Drug R & D and Preclinical Safety, Zhengzhou University, Zhengzhou, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S07533322183325
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http://dx.doi.org/10.1016/j.biopha.2018.08.140DOI Listing
November 2018

USP28 contributes to the proliferation and metastasis of gastric cancer.

J Cell Biochem 2018 Nov 28. Epub 2018 Nov 28.

Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Co-innovation Center of Henan Province for New Drug R & D and Preclinical Safety, Institute of Drug Discovery and Development, Zhengzhou University, Zhengzhou, Henan, China.

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http://dx.doi.org/10.1002/jcb.28040DOI Listing
November 2018

Discovery of a non-toxic [1,2,4]triazolo[1,5-a]pyrimidin-7-one (WS-10) that modulates ABCB1-mediated multidrug resistance (MDR).

Bioorg Med Chem 2018 10 18;26(18):5006-5017. Epub 2018 Aug 18.

School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China; Co-Innovation Center of Henan Province for New Drug R & D and Preclinical Safety, Zhengzhou 450001, China; Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education of China, Zhengzhou 450001, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09680896183066
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http://dx.doi.org/10.1016/j.bmc.2018.08.021DOI Listing
October 2018

Design, synthesis and biological mechanisms research on 1,2,3-triazole derivatives of Jiyuan Oridonin A.

Bioorg Med Chem 2018 09 4;26(17):4761-4773. Epub 2017 Nov 4.

Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education of China, Key Laboratory of Henan Province for Drug Quality and Evaluation, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2017.11.005DOI Listing
September 2018

Synthesis and biological evaluation of novel Jiyuan Oridonin A-1,2,3-triazole-azole derivatives as antiproliferative agents.

Eur J Med Chem 2018 Sep 22;157:1249-1263. Epub 2018 Aug 22.

School of Pharmaceutical Sciences, Institute of Drug Discovery and Development, Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Zhengzhou University, Zhengzhou, 450001, PR China; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, Zhengzhou, 450001, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2018.08.056DOI Listing
September 2018

Generation and characterization of a paclitaxel-resistant human gastric carcinoma cell line.

Anticancer Drugs 2018 07;29(6):491-502

Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Zhengzhou University.

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http://dx.doi.org/10.1097/CAD.0000000000000601DOI Listing
July 2018

Discovery of 5-Cyano-6-phenylpyrimidin Derivatives Containing an Acylurea Moiety as Orally Bioavailable Reversal Agents against P-Glycoprotein-Mediated Mutidrug Resistance.

J Med Chem 2018 Jul 18;61(14):5988-6001. Epub 2018 Jul 18.

Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province; Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education; Key Laboratory of Henan Province for Drug Quality and Evaluation; School of Pharmaceutical Sciences , Zhengzhou University , Zhengzhou 450001 , P. R. China.

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http://dx.doi.org/10.1021/acs.jmedchem.8b00335DOI Listing
July 2018

Lysine-specific demethylase 1 activation by vitamin B2 attenuates efficacy of apatinib for proliferation and migration of gastric cancer cell MGC-803.

J Cell Biochem 2018 06 9;119(6):4957-4966. Epub 2018 Mar 9.

Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Co-innovation Center of Henan Province for New Drug R & D and Preclinical Safety, Institute of Drug Discovery and Development, Zhengzhou University, Zhengzhou, Henan, China.

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http://dx.doi.org/10.1002/jcb.26741DOI Listing
June 2018

Discovery of 6-chloro-2-(propylthio)-8,9-dihydro-7H-purines containing a carboxamide moiety as potential selective anti-lung cancer agents.

Eur J Med Chem 2018 May 3;151:327-338. Epub 2018 Apr 3.

Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education of China, Key Laboratory of Henan Province for Drug Quality and Evaluation, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2018.03.084DOI Listing
May 2018

Potent hydrazone derivatives targeting esophageal cancer cells.

Eur J Med Chem 2018 Mar 14;148:359-371. Epub 2018 Feb 14.

Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Co-innovation Center of Henan Province for New Drug R & D and Preclinical Safety, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan, 450001, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2018.02.033DOI Listing
March 2018

Synthesis and biological evaluation of new steroidal pyridines as potential anti-prostate cancer agents.

Eur J Med Chem 2018 Feb 2;145:11-22. Epub 2018 Jan 2.

Key Laboratory of Advanced Drug Preparation Technologies (Zhengzhou University), Ministry of Education, PR China; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, PR China; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, PR China; Key Laboratory of Henan Province for Drug Quality and Evaluation, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2017.12.094DOI Listing
February 2018

Design, synthesis and in vitro biological evaluation of novel [1,2,3]triazolo[4,5-d]pyrimidine derivatives containing a thiosemicarbazide moiety.

Eur J Med Chem 2018 Feb 17;146:147-156. Epub 2018 Jan 17.

Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education of China, Key Laboratory of Henan Province for Drug Quality and Evaluation, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2018.01.031DOI Listing
February 2018

Synthesis and preliminary antiproliferative activity of new pteridin-7(8H)-one derivatives.

Eur J Med Chem 2018 Jan 16;143:1396-1405. Epub 2017 Oct 16.

Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, Zhengzhou 450001, PR China; Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education of China, Zhengzhou 450001, PR China; Key Laboratory of Henan Province for Drug Quality and Evaluation, Zhengzhou 450001, PR China; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2017.10.037DOI Listing
January 2018

Exploration of 1,2,3-triazole-pyrimidine hybrids as potent reversal agents against ABCB1-mediated multidrug resistance.

Eur J Med Chem 2018 Jan 21;143:1535-1542. Epub 2017 Oct 21.

Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education of China, Key Laboratory of Henan Province for Drug Quality and Evaluation, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2017.10.041DOI Listing
January 2018

Synthesis and bioactivities study of new antibacterial peptide mimics: The dialkyl cationic amphiphiles.

Eur J Med Chem 2018 Jan 17;143:1489-1509. Epub 2017 Oct 17.

School of Pharmaceutical Sciences, Institute of Drug Discovery and Development, Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Zhengzhou University, Zhengzhou 450001, PR China; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, Zhengzhou 450001, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2017.10.044DOI Listing
January 2018

Design, synthesis and preliminary biological evaluation of 5,8-dihydropteridine-6,7-diones that induce apoptosis and suppress cell migration.

Eur J Med Chem 2018 Jan 5;143:1959-1967. Epub 2017 Nov 5.

Key Laboratory of Advanced Drug Preparation Technologies (Zhengzhou University), Ministry of Education, Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, PR China; Key Laboratory of Henan Province for Drug Quality and Evaluation, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2017.11.009DOI Listing
January 2018

Thiosemicarbazone-based selective proliferation inactivators inhibit gastric cancer cell growth, invasion, and migration.

Medchemcomm 2017 Dec 23;8(12):2173-2180. Epub 2017 Oct 23.

Collaborative Innovation Center of New Drug Research and Safety Evaluation , Key Laboratory of Technology of Drug Preparation , Ministry of Education of China , School of Pharmaceutical Sciences , Zhengzhou University , Zhengzhou 450001 , Henan Province , PR China . Email: ; Email:

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http://dx.doi.org/10.1039/c7md00353fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072408PMC
December 2017

Molecular diversity of phenothiazines: design and synthesis of phenothiazine-dithiocarbamate hybrids as potential cell cycle blockers.

Mol Divers 2017 Nov 7;21(4):933-942. Epub 2017 Aug 7.

New Drug Research and Development Center, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China.

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http://dx.doi.org/10.1007/s11030-017-9773-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5975273PMC
November 2017

Gene expression profiling and pathway network analysis of anti-tumor activity by Jaridon 6 in esophageal cancer.

Eur J Pharmacol 2017 Nov 9;815:478-486. Epub 2017 Aug 9.

School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, PR China; Key Laboratory of Henan Province for Drug Quality and Evaluation, Zhengzhou 450001, PR China; Key Laboratory of Technology of Drug Preparation, Ministry of Education, Zhengzhou 450001, PR China; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Zhengzhou 450001, Henan Province, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2017.08.004DOI Listing
November 2017

Discovery of tranylcypromine analogs with an acylhydrazone substituent as LSD1 inactivators: Design, synthesis and their biological evaluation.

Bioorg Med Chem Lett 2017 11 3;27(22):5036-5039. Epub 2017 Oct 3.

Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, PR China; Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education of China, PR China; Key Laboratory of Henan Province for Drug Quality and Evaluation, PR China; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2017.10.003DOI Listing
November 2017

Design, synthesis and preliminary biological evaluation of new [1,2,3]triazolo[4,5-d]pyrimidine/thiourea hybrids as antiproliferative agents.

Eur J Med Chem 2017 Oct 31;139:741-749. Epub 2017 Aug 31.

Key Laboratory of Advanced Drug Preparation Technologies (Zhengzhou University), Ministry of Education; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, PR China; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, PR China; Key Laboratory of Henan Province for Drug Quality and Evaluation, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2017.08.042DOI Listing
October 2017

Structure-Activity Relationship Studies of β-Lactam-azide Analogues as Orally Active Antitumor Agents Targeting the Tubulin Colchicine Site.

Sci Rep 2017 10 6;7(1):12788. Epub 2017 Oct 6.

School of Pharmaceutical Sciences & Collaborative Innovation Center of New Drug Research and Safety Evaluation, Zhengzhou University, Zhengzhou, 450001, China.

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http://dx.doi.org/10.1038/s41598-017-12912-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630639PMC
October 2017

An Overview on Screening Methods for Lysine Specific Demethylase 1 (LSD1) Inhibitors.

Curr Med Chem 2017 ;24(23):2496-2504

School of Pharmaceutical Sciences, Zhengzhou University, P.O. Box: 450001, Zhengzhou. China.

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http://dx.doi.org/10.2174/0929867324666170509114321DOI Listing
September 2017

OP16, a novel ent-kaurene diterpenoid, potentiates the antitumor effect of rapamycin by inhibiting rapamycin-induced feedback activation of Akt signaling in esophageal squamous cell carcinoma.

Biochem Pharmacol 2017 09 21;140:16-27. Epub 2017 May 21.

School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2017.05.013DOI Listing
September 2017

Design, synthesis and antiproliferative activity of thiazolo[5,4-d]pyrimidine derivatives through the atom replacement strategy.

Eur J Med Chem 2017 Sep 22;138:1034-1041. Epub 2017 Jul 22.

Key Laboratory of Advanced Drug Preparation Technologies (Zhengzhou University), Ministry of Education, PR China; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, PR China; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, PR China; Key Laboratory of Henan Province for Drug Quality and Evaluation, PR China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S02235234173056
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http://dx.doi.org/10.1016/j.ejmech.2017.07.039DOI Listing
September 2017

Discovery of 5,6-diaryl-1,2,4-triazines hybrids as potential apoptosis inducers.

Eur J Med Chem 2017 Sep 8;138:1076-1088. Epub 2017 Jul 8.

New Drug Research & Development Center, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, China; Key Laboratory of Technology of Drug Preparation, Zhengzhou University, Ministry of Education, China; Key Laboratory of Henan Province for Drug Quality and Evaluation, China. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2017.07.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5975277PMC
September 2017

Design, synthesis and preliminary antiproliferative activity studies of new diheteroaryl thioether derivatives.

Bioorg Med Chem Lett 2017 09 18;27(18):4377-4382. Epub 2017 Aug 18.

Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, PR China; Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education of China, PR China; Key Laboratory of Henan Province for Drug Quality and Evaluation; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2017.08.021DOI Listing
September 2017

LPE-1, an orally active pyrimidine derivative, inhibits growth and mobility of human esophageal cancers by targeting LSD1.

Pharmacol Res 2017 Aug 30;122:66-77. Epub 2017 May 30.

School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, China; Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education, China; Key Laboratory of Henan Province for Drug Quality and Evaluation, China. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2017.05.025DOI Listing
August 2017

3D-QSAR (CoMFA, CoMSIA), molecular docking and molecular dynamics simulations study of 6-aryl-5-cyano-pyrimidine derivatives to explore the structure requirements of LSD1 inhibitors.

Bioorg Med Chem Lett 2017 08 24;27(15):3521-3528. Epub 2017 May 24.

Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education of China, Key Laboratory of Henan Province for Drug Quality and Evaluation, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2017.05.065DOI Listing
August 2017

Design, synthesis, and biological evaluation of new thiazolo[5,4-]pyrimidine derivatives as potent antiproliferative agents.

Medchemcomm 2017 Aug 22;8(8):1655-1658. Epub 2017 Jun 22.

Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province , Key Laboratory of Technology of Drug Preparation (Zhengzhou University) , Ministry of Education of China , Key Laboratory of Henan Province for Drug Quality and Evaluation , School of Pharmaceutical Sciences , Zhengzhou University , Zhengzhou 450001 , PR China . Email: ; Email:

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http://dx.doi.org/10.1039/c7md00165gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071795PMC
August 2017

A novel chalcone derivative S17 induces apoptosis through ROS dependent DR5 up-regulation in gastric cancer cells.

Sci Rep 2017 08 29;7(1):9873. Epub 2017 Aug 29.

School of Pharmaceutical Sciences, Key Laboratory of State Ministry of Education, Key Laboratory of Henan province for Drug Quality Control and Evaluation, Collaborative Innovation Center of New Drug Research and Safety Evaluation, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan, 450001, China.

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http://dx.doi.org/10.1038/s41598-017-10400-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575266PMC
August 2017

Pro-Apoptotic Effects of JDA-202, a Novel Natural Diterpenoid, on Esophageal Cancer Through Targeting Peroxiredoxin I.

Antioxid Redox Signal 2017 07 1;27(2):73-92. Epub 2016 Nov 1.

Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Co-Innovation Center of Henan Province for New Drug R & D and Preclinical Safety, School of Pharmaceutical Sciences, Zhengzhou University , Zhengzhou, China .

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http://dx.doi.org/10.1089/ars.2016.6703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510680PMC
July 2017

Identification of thiazolo[5,4-d]pyrimidine derivatives as potent antiproliferative agents through the drug repurposing strategy.

Eur J Med Chem 2017 Jul 22;135:204-212. Epub 2017 Apr 22.

Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education of China, Key Laboratory of Henan Province for Drug Quality and Evaluation, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2017.04.056DOI Listing
July 2017

Natural Product-Derived Spirooxindole Fragments Serve as Privileged Substructures for Discovery of New Anticancer Agents.

Anticancer Agents Med Chem 2016 ;16(10):1315-24

School of Pharmaceutical Sciences and New Drug Research & Development Center, Zhengzhou University, Zhengzhou 450001, P. R. China.

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http://dx.doi.org/10.2174/1871520615666151102093825DOI Listing
May 2017

Discovery of [1,2,3]Triazolo[4,5-]pyrimidine Derivatives as Novel LSD1 Inhibitors.

ACS Med Chem Lett 2017 Apr 6;8(4):384-389. Epub 2017 Mar 6.

Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education; Key Laboratory of Henan Province for Drug Quality and Evaluation; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province; Institute of Drug Discovery and Development, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan 450001, China.

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http://dx.doi.org/10.1021/acsmedchemlett.6b00423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392756PMC
April 2017

Downregulation of p70S6K Enhances Cell Sensitivity to Rapamycin in Esophageal Squamous Cell Carcinoma.

J Immunol Res 2016 9;2016:7828916. Epub 2016 Aug 9.

School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan 450001, China; New Drug Research and Development Centre of Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan 450001, China.

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http://dx.doi.org/10.1155/2016/7828916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993948PMC
March 2017

Geridonin, a novel derivative of oridonin, inhibits proliferation of MGC 803 cells both in vitro and in vivo through elevating the intracellular ROS.

J Pharm Pharmacol 2017 Feb 28;69(2):213-221. Epub 2016 Dec 28.

Co-innovation Center of Henan Province for New Drug R & D and Preclinical Safety, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China.

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http://dx.doi.org/10.1111/jphp.12678DOI Listing
February 2017

Design and synthesis of formononetin-dithiocarbamate hybrids that inhibit growth and migration of PC-3 cells via MAPK/Wnt signaling pathways.

Eur J Med Chem 2017 Feb 14;127:87-99. Epub 2016 Dec 14.

School of Pharmaceutical Sciences & Collaborative Innovation Center of New Drug Research and Safety Evaluation, Zhengzhou University, Zhengzhou 450001, China. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2016.12.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567725PMC
February 2017

Design, synthesis and biological evaluation of [1,2,4]triazolo[1,5-a]pyrimidines as potent lysine specific demethylase 1 (LSD1/KDM1A) inhibitors.

Eur J Med Chem 2017 Jan 14;125:940-951. Epub 2016 Oct 14.

School of Pharmaceutical Sciences & Collaborative Innovation Center of New Drug Research and Safety Evaluation, Zhengzhou University, Zhengzhou 450001, China. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2016.10.021DOI Listing
January 2017

Discovery of resveratrol derivatives as novel LSD1 inhibitors: Design, synthesis and their biological evaluation.

Eur J Med Chem 2017 Jan 16;126:246-258. Epub 2016 Nov 16.

Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Co-innovation Center of Henan Province for New Drug R & D and Preclinical Safety, Institute of Drug Discovery and Development, School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan 450001, China. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2016.11.035DOI Listing
January 2017

Baicalin, a natural LSD1 inhibitor.

Bioorg Chem 2016 12 11;69:129-131. Epub 2016 Oct 11.

Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Zhengzhou, Henan 450001, PR China; Co-Innovation Center of Henan Province for New Drug R & D and Preclinical Safety, Zhengzhou, Henan 450001, PR China; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2016.10.004DOI Listing
December 2016

New Non-Nucleocide NS5B Protein Inhibitors for the Treatment of Chronic Hepatitis C Infection.

Curr Top Med Chem 2016 ;16(12):1392-401

School of Pharmaceutical Sciences of Zhengzhou University, zhengzhou, China.

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http://dx.doi.org/10.2174/1568026616666151120113933DOI Listing
November 2016

Corrigendum to "Discovery of orally active anticancer candidate CFI-400945 derived from biologically promising spirooxindoles: Success and challenges" [Eur. J. Med. Chem. 95 (2015) 35-40].

Eur J Med Chem 2016 11 3;124:248. Epub 2016 Sep 3.

School of Pharmaceutical Sciences and New Drug Research & Development Center, Zhengzhou University, Zhengzhou 450001, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2016.08.040DOI Listing
November 2016

Design and synthesis of isatin/triazole conjugates that induce apoptosis and inhibit migration of MGC-803 cells.

Eur J Med Chem 2016 Nov 28;124:350-360. Epub 2016 Aug 28.

School of Pharmaceutical Sciences & Collaborative Innovation Center of New Drug Research and Safety Evaluation, Zhengzhou University, Zhengzhou 450001, China. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2016.08.065DOI Listing
November 2016

Solvent-free synthesis of novel steroidal 2-aminopyridines.

Steroids 2016 11 14;115:147-153. Epub 2016 Sep 14.

School of Pharmaceutical Sciences of Zhengzhou University and Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, No. 100, KeXue DaDao, Zhengzhou 450001, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.steroids.2016.09.005DOI Listing
November 2016

Synthesis and glycosidase inhibition evaluation of (3S,4S)-3-((R)-1,2-dihydroxyethyl)pyrrolidine-3,4-diol.

Carbohydr Res 2016 Nov 9;434:33-36. Epub 2016 Aug 9.

School of Pharmaceutical Sciences, Institute of Drug Discovery and Development, Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Zhengzhou University, Zhengzhou, 450001, PR China; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, Zhengzhou, 450001, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.carres.2016.08.003DOI Listing
November 2016

Design, synthesis and biological evaluation of [1,2,3]triazolo[4,5-d]pyrimidine derivatives possessing a hydrazone moiety as antiproliferative agents.

Eur J Med Chem 2016 Nov 14;124:967-980. Epub 2016 Oct 14.

School of Pharmaceutical Science & Collaborative Innovation Center of New Drug Research and Safety Evaluation, Zhengzhou University, Zhengzhou, 450001, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2016.10.022DOI Listing
November 2016

1,2,3-Triazole-Dithiocarbamate Hybrids, a Group of Novel Cell Active SIRT1 Inhibitors.

Cell Physiol Biochem 2016 20;38(1):185-93. Epub 2016 Jan 20.

Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China; Co-innovation Center of Henan Province for New drug R & D and Preclinical Safety; Institute of Drug Discovery and Development, Zhengzhou University, Zhengzhou, China.

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http://dx.doi.org/10.1159/000438620DOI Listing
October 2016

A new brominated chalcone derivative suppresses the growth of gastric cancer cells in vitro and in vivo involving ROS mediated up-regulation of DR5 and 4 expression and apoptosis.

Toxicol Appl Pharmacol 2016 10 2;309:77-86. Epub 2016 Sep 2.

School of Pharmaceutical Sciences, Key Laboratory of State Ministry of Education, Key Laboratory of Henan province for Drug Quality Control and Evaluation, Collaborative Innovation Center of New Drug Research and Safety Evaluation, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan 450001, China. Electronic address:

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http://dx.doi.org/10.1016/j.taap.2016.08.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507202PMC
October 2016

Design, synthesis and antiproliferative activity studies of novel dithiocarbamate-chalcone derivates.

Bioorg Med Chem Lett 2016 08 5;26(16):3918-22. Epub 2016 Jul 5.

Collaborative Innovation Center of New Drug Research and Safety Evaluation, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, PR China.

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http://dx.doi.org/10.1016/j.bmcl.2016.07.012DOI Listing
August 2016

Structurally novel steroidal spirooxindole by241 potently inhibits tumor growth mainly through ROS-mediated mechanisms.

Sci Rep 2016 08 16;6:31607. Epub 2016 Aug 16.

School of Pharmaceutical Sciences &Collaborative Innovation Center of New Drug Research and Safety Evaluation, Zhengzhou University, Zhengzhou 450001, China.

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http://dx.doi.org/10.1038/srep31607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985843PMC
August 2016

Efficient synthesis of new antiproliferative steroidal hybrids using the molecular hybridization approach.

Eur J Med Chem 2016 Jul 12;117:241-55. Epub 2016 Apr 12.

School of Pharmaceutical Sciences & Collaborative Innovation Center of New Drug Research and Safety Evaluation, Zhengzhou University, Zhengzhou, 450001, China. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2016.04.024DOI Listing
July 2016

Catalytic asymmetric synthesis of biologically important 3-hydroxyoxindoles: an update.

Beilstein J Org Chem 2016 18;12:1000-1039. Epub 2016 May 18.

School of Pharmaceutical Sciences & Collaborative Innovation Center of New Drug Research and Safety Evaluation, Zhengzhou University, Zhengzhou 450001, China.

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http://dx.doi.org/10.3762/bjoc.12.98DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902056PMC
June 2016

Multicomponent assembly of novel antiproliferative steroidal dihydropyridinyl spirooxindoles.

Steroids 2016 May 11;109:22-8. Epub 2016 Mar 11.

School of Pharmaceutical Sciences of Zhengzhou University and Collaborative Innovation Center of New Drug Research and Safety Evaluation, Zhengzhou 450001, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.steroids.2016.03.005DOI Listing
May 2016

TCPs: privileged scaffolds for identifying potent LSD1 inhibitors for cancer therapy.

Epigenomics 2016 05 22;8(5):651-66. Epub 2016 Apr 22.

Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China; Co-innovation Center of Henan Province for New drug R&D & Preclinical Safety; Institute of Drug Discovery & Development, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan 450001, China.

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http://dx.doi.org/10.2217/epi-2015-0002DOI Listing
May 2016

Design, Synthesis and Structure-Activity Relationships of Novel Chalcone-1,2,3-triazole-azole Derivates as Antiproliferative Agents.

Molecules 2016 May 19;21(5). Epub 2016 May 19.

Collaborative Innovation Center of New Drug Research and Safety Evaluation, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.

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http://www.mdpi.com/1420-3049/21/5/653
Publisher Site
http://dx.doi.org/10.3390/molecules21050653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274517PMC
May 2016

Efficient three-component one-pot synthesis of steroidal polysubstituted anilines.

Steroids 2015 Dec 22;104:1-7. Epub 2015 Jul 22.

School of Pharmaceutical Sciences of Zhengzhou University and Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, No. 100, KeXue DaDao, Zhengzhou 450001, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.steroids.2015.07.005DOI Listing
December 2015

Efficient synthesis of novel antiproliferative steroidal spirooxindoles via the [3+2] cycloaddition reactions of azomethine ylides.

Steroids 2015 Oct 6;102:92-100. Epub 2015 Aug 6.

School of Pharmaceutical Sciences and New Drug Research & Development Center, Zhengzhou University, Zhengzhou 450001, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.steroids.2015.08.003DOI Listing
October 2015

Synthesis and in vitro antiviral activities of [(dihydrofuran-2-yl)oxy]methyl-phosphonate nucleosides with 2-substituted adenine as base.

Chem Biodivers 2015 May;12(5):813-22

Medicinal Chemistry, Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, BE-3000 Leuven.

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http://dx.doi.org/10.1002/cbdv.201400418DOI Listing
May 2015