Publications by authors named "Hong Zhao"

1,962 Publications

  • Page 1 of 1

The impact of the COVID-19 outbreak on physical fitness and academic performance of Chinese college students.

J Am Coll Health 2022 Jun 23:1-8. Epub 2022 Jun 23.

Harris School of Public Policy, University of Chicago, Chicago, Illinois, USA.

Background: Our study aimed to examine the effects of COVID-19 on the physical fitness and academic performance of Chinese college students.

Participants: The sample included physical fitness test data from 9,712 undergraduate students and academic performance data from 12,000 undergraduate students at a top university in China.

Methods: Physical fitness was measured and evaluated according to the Chinese National Student Physical Fitness Standard. Data were analyzed using two-sample t-tests and Pearson product-moment correlations.

Results: Total physical fitness test scores of college students decreased after the outbreak, but their mean body mass index (BMI) remained at normal levels. The mean academic performance of college students unexpectedly improved during the online learning period. The positive correlation between physical test scores and academic performance was significantly higher during COVID-19 than that before the outbreak.

Conclusions: Chinese college students with high physical fitness during COVID-19 were more likely to achieve good academic performance.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1080/07448481.2022.2087472DOI Listing
June 2022

Analysis on Acupoint Selection and Combination for Amyotrophic Lateral Sclerosis Treated with Acupuncture Based on Data Mining.

Evid Based Complement Alternat Med 2022 8;2022:6541600. Epub 2022 Jun 8.

Teaching Affairs Department, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China.

Objective: The aim of the study was to explore the regularity of acupoints in the treatment of amyotrophic lateral sclerosis (ALS) by means of data mining technology.

Methods: Nine databases, including SinoMed, Chongqing VIP (CQVIP), China National Knowledge Infrastructure (CNKI), Wanfang Data, Cochrane Library, PubMed, MEDLINE, Web of Science, and Embase, were comprehensively searched till December 2021. The published clinical literature testing acupuncture in the treatment of ALS was eligible for inclusion. Studies were organized to establish the prescription database. Modular data mining analysis, including acupoint frequency, complex network analysis, association rule analysis, and cluster analysis were used to conduct statistical analysis.

Results: Forty-two literature studies on 141 acupoints were included, involving 626 times the total application frequency. The top 5 acupoints in application frequency were Hegu (LI 4, 67%), Zusanli (ST 36, 67%), Quchi (LI 11, 52%), Sanyinjiao (SP 6, 48%), and Yanglingquan (GB 34, 45%). The most involved meridian was the large intestine meridian of hand Yangming (90 times). The generally used acupoints were mainly distributed in the lower limbs. The top 5 combinations in application frequency were Hegu-Quchi (75 times), Quchi-Zusanli (66 times), Zusanli-Sanyinjiao (54 times), Hegu-Sanyinjiao (54 times), and Quchi-Sanyinjiao (49 times). The acupoint combinations with the strongest association were Quchi, Hegu, Zusanli, Sanyinjiao, and Shousanli (LI 10). There were 7 acupoint groups according to the cluster analysis. The core prescriptions were Hegu, Zusanli, Quchi, and Jiaji (EX-B 2).

Conclusions: Hegu, Zusanli, Quchi, and Jiaji could be used as the main prescriptions in treating ALS. The combination of Quchi, Hegu, Zusanli, and Sanyinjiao should be selected with priority in acupuncture therapy.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1155/2022/6541600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9200494PMC
June 2022

Understanding the Mechanism of User Experience Role in Educational Livestreaming Platform.

Front Psychol 2022 26;13:907929. Epub 2022 May 26.

College of Finance and Economics, Nanchang Institute of Technology, Nanchang, China.

The booming development of educational livestreaming platforms has caused the prevalence of user experience to a certain extent, which profoundly affects users' purchase intention and behavior, and has become a hot topic of current research in the online education field. However, there is a lack of in-depth analysis on the mechanism of the role of user experience in influencing purchase intention. Based on the analysis of user experience and psychological ownership, this study constructs a moderated mediation model to investigate the mediating psychological mechanism and boundary conditions of user experience affecting purchase intention. In this study, a valid sample of 372 users was used for structural equation modeling analysis. The results of the study found that user experience not only had a significant positive effect on purchase intention but was also mediated by psychological ownership. We also found that the effect of psychological ownership on purchase intention was moderated by privacy concerns. This study examines the role of user experience in purchase intention and reveals the mechanism of the role of user experience in an educational livestreaming platform.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fpsyg.2022.907929DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9204627PMC
May 2022

Identification of Upper Gastrointestinal Diseases during Screening Gastroscopy through Deep Convolutional Neural Network Algorithm.

Gastrointest Endosc 2022 Jun 16. Epub 2022 Jun 16.

Department of Clinical Research Center, Dazhou Central Hospital, Dazhou, Sichuan, China; Center of Intelligent Medicine, Computer Science, Sichuan University, Chengdu, Sichuan, China. Electronic address:

Background And Aims: The clinical application of gastrointestinal endoscopy for the diagnosis of multiple diseases using artificial intelligence (AI) has been limited by its high false positive rates. There is an unmet need to develop a Gastrointestinal Endoscopy AI-assisted Diagnosis System (GEADS) to improve diagnostic accuracy and clinical utility.

Methods: In this retrospective, multicenter study, a convolutional neural network was trained to assess upper gastrointestinal diseases based on 26,228 endoscopic images from Dazhou Central Hospital that were randomly assigned (3:1:1) to the training dataset, validation dataset, and test dataset, respectively. To validate the model, 6 external independent datasets comprising 51,372 images of upper gastrointestinal diseases were collected. Besides, one prospective dataset comprising 27,975 images were collected. The performance of GEADS was compared with endoscopists with two professional degrees of expertise: expert, novice. 8 endoscopists in the expert group with more than 5 years of experience, 3 endoscopists in the novice group with 1 to 5 years of experience.

Results: The GEADS model achieved an accuracy of 0.918 (95% confidence interval [CI]: 0.914-0.922), with an F1 score of 0.884 (95% CI: 0.879-0.889), recall of 0.873 (95% CI: 0.868-0.878) and a precision of 0.890 (95% CI: 0.885-0.895) in the internal validation dataset. In the external validation datasets and one prospective validation dataset, the diagnostic accuracy of GEADS ranged from 0.841 (95% CI: 0.834-0.848) to 0.949 (95% CI: 0.935-0.963). With the help of GEADS, the diagnosing accuracies of novice and expert endoscopists were significantly improved (P < 0.001).

Conclusions: The AI system can assist endoscopists in improving the accuracy of diagnosing upper gastrointestinal diseases.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.gie.2022.06.011DOI Listing
June 2022

Chromosome-level and haplotype-resolved genome provides insight into the tetraploid hybrid origin of patchouli.

Nat Commun 2022 Jun 18;13(1):3511. Epub 2022 Jun 18.

Institute of Medicinal Plant Physiology and Ecology, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China.

Patchouli (Pogostemon cablin (Blanco) Benth.), a member of the Lamiaceae family, is an important aromatic plant that has been widely used in medicine and perfumery. Here, we report a 1.94 Gb chromosome-scale assembly of the patchouli genome (contig N50 = 7.97 Mb). The gene annotation reveals that tandem duplication of sesquiterpene biosynthetic genes may be a major contributor to the biosynthesis of patchouli bioactivity components. We further phase the genome into two distinct subgenomes (A and B), and identify a chromosome substitution event that have occurred between them. Further investigations show that a burst of universal LTR-RTs in the A subgenome lead to the divergence between two subgenomes. However, no significant subgenome dominance is detected. Finally, we track the evolutionary scenario of patchouli including whole genome tetraploidization, subgenome divergency, hybridization, and chromosome substitution, which are the key forces to determine the complexity of patchouli genome. Our work sheds light on the evolutionary history of patchouli and offers unprecedented genomic resources for fundamental patchouli research and elite germplasm development.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-022-31121-wDOI Listing
June 2022

BCAP31 is involved in modulating colorectal cancer cell proliferation via the Emerin/β-catenin axis.

Exp Cell Res 2022 Jun 15;418(1):113265. Epub 2022 Jun 15.

Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, 610065, China. Electronic address:

Understanding the mechanisms of colorectal cancer (CRC) progression is critical for developing innovative treatment strategies. As an endoplasmic reticulum-located protein, B cell receptor-associated protein 31 (BCAP31) has been identified to be highly expressed in multiple cancers. However, its function and molecular mechanism in CRC remain not fully understood. In the present study, BCAP31 expression and its correlation with the clinical stage were analyzed based on TCGA database. We demonstrated that loss of BCAP31 suppressed CRC cell proliferation in vitro and tumor growth in vivo. Mechanistically, we demonstrated that Emerin was an interaction partner and downstream molecule of BCAP31. Knockdown of BCAP31 promoted the nuclear envelope localization of Emerin, leading to a reduction of β-catenin accumulation in the nucleus, which resulted in downregulation of Wnt/β-catenin downstream target genes, including c-Myc, cyclin D1, Survivin, and Mcl-1. Moreover, downregulation of Emerin partially restored the BCAP31 depletion-mediated β-catenin protein level and tumor suppressive effects in CRC cells.Our data highlights the pivotal role of BCAP31 depletion in inhibiting cell proliferation in CRC cells, and mechanistically via Emerin/β-catenin signaling, which may serve as a promising target for CRC treatment.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yexcr.2022.113265DOI Listing
June 2022

Factors Affecting Transfusion during Percutaneous Nephrolithotomy: A Retrospective Study of 665 Cases.

Appl Bionics Biomech 2022 6;2022:6775277. Epub 2022 Jun 6.

Department of Transfusion, Shanghai Xu-Hui Central Hospital, Shanghai 200032, China.

Objective: This study was designed to evaluate the aspects that affect transfusion following percutaneous nephrolithotomy (PCNL). . From 2016 to 2019, 665 patients underwent PCNL for the removal of renal calculi at our center (Department of Urology, Shanghai Xu-hui Central Hospital). Complications, including hemorrhages, have been reported. Twenty-three patients (3.5%) have received a blood transfusion, and 12 (1.9%) patients were treated with hyper-selective embolization. We focused on the influencing factors related to postoperative blood transfusion. The factors analyzed were age, sex, hypertension, diabetes, serum creatinine level, preoperative hemoglobin, and the use of anticoagulants or antiplatelet medications; renal and stone factors (i.e., previous surgery, abnormal anatomy, stone side, stone burden, and stone type); and surgical features (i.e., access number, the calyx of puncture, and stone-free rate). These data were analyzed for the presence of bleeding.

Results: Among individual factors, preoperative hemoglobin level ( < 0.001) and urinary infections ( < 0.001) were significantly correlated with blood transfusion. Among renal and stone factors, only a history of open surgery was significantly correlated with blood transfusion ( < 0.05). Stone type or stone burden did not correlate with transfusion. Furthermore, no statistically significant correlation was found between surgical features and bleeding, and a lower stone-free rate was reported for the transfusion group.

Conclusion: The obtained results demonstrated that PCNL is a safer surgical procedure in a high-volume center; however, anemic conditions, infections, and history of open surgery will significantly increase the transfusion rate following PCNL.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1155/2022/6775277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9192292PMC
June 2022

RING finger 138 deregulation distorts NF-кB signaling and facilities colitis switch to aggressive malignancy.

Signal Transduct Target Ther 2022 Jun 13;7(1):185. Epub 2022 Jun 13.

Department of Biochemistry and Molecular Biology, State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, 100005, China.

Prolonged activation of nuclear factor (NF)-кB signaling significantly contributes to the development of colorectal cancer (CRC). New therapeutic opportunities are emerging from targeting this distorted cell signaling transduction. Here, we discovered the critical role of RING finger 138 (RNF138) in CRC tumorigenesis through regulating the NF-кB signaling, which is independent of its Ubiquitin-E3 ligase activity involved in DNA damage response. RNF138 mice were hyper-susceptible to the switch from colitis to aggressive malignancy, which coincided with sustained aberrant NF-кB signaling in the colonic cells. Furthermore, RNF138 suppresses the activation of NF-кB signaling pathway through preventing the translocation of NIK and IKK-Beta Binding Protein (NIBP) to the cytoplasm, which requires the ubiquitin interaction motif (UIM) domain. More importantly, we uncovered a significant correlation between poor prognosis and the downregulation of RNF138 associated with reinforced NF-кB signaling in clinical settings, raising the possibility of RNF138 dysregulation as an indicator for the therapeutic intervention targeting NF-кB signaling. Using the xenograft models built upon either RNF138-dificient CRC cells or the cells derived from the RNF138-dysregulated CRC patients, we demonstrated that the inhibition of NF-кB signaling effectively hampered tumor growth. Overall, our work defined the pathogenic role of aberrant NF-кB signaling due to RNF138 downregulation in the cascade events from the colitis switch to colonic neoplastic transformation and progression, and also highlights the possibility of targeting the NF-кB signaling in treating specific subtypes of CRC indicated by RNF138-ablation.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41392-022-00985-1DOI Listing
June 2022

The chromosome-scale assembly of endive (Cichorium endivia) genome provides insights into the sesquiterpenoid biosynthesis.

Genomics 2022 Jun 9;114(4):110400. Epub 2022 Jun 9.

National Engineering Research Center for Vegetables, Beijing Vegetable Research Center, Beijing Academy of Agriculture and Forestry Science, Beijing 100097, PR China; Beijing Key Laboratory of Vegetable Germplasm Improvement, Beijing 100097, PR China; Key Laboratory of Biology and Genetic Improvement of Horticultural Crops (North China), Ministry of Agriculture and Rural Affairs of the P. R. China, Beijing 100097, PR China. Electronic address:

Endive (Cichorium endivia L.) is a leafy vegetable in the Asteraceae family. Sesquiterpene lactones (STLs) in endive leaves bring a bitter taste that varies between varieties. Despite their importance in breeding varieties with unique flavours, sesquiterpenoid biosynthesis pathways in endive are poorly understood. We assembled a chromosome-scale endive genome of 641 Mb with a contig N50 of 5.16 Mb and annotated 46,711 protein-coding genes. Several gene families, especially terpene synthases (TPS) genes, expanded significantly in the C. endivia genome. STLs biosynthesis-related genes and TPS genes in more bitter varieties have shown a higher level of expression, which could be attributed to genomic variations. Our results penetrate the origin and diversity of bitter taste and facilitate the molecular breeding of endive varieties with unique bitter tastes. The high-quality endive assembly would provide a reference genome for studying the evolution and diversity of Asteraceae.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ygeno.2022.110400DOI Listing
June 2022

FDA Approval Summary: Cabozantinib for Differentiated Thyroid Cancer.

Clin Cancer Res 2022 Jun 9. Epub 2022 Jun 9.

Food and Drug Administration, Silver Spring, United States.

On September 17, 2021, the U.S. Food and Drug Administration (FDA) approved cabozantinib (Cabometyx; Exelixis, Inc.) for the treatment of adult and pediatric patients 12 years of age and older with locally advanced or metastatic differentiated thyroid cancer (DTC) that has progressed following prior VEGFR-targeted therapy and who are radioactive iodine (RAI)-refractory or ineligible. This is the first approval for patients with RAI-refractory locally advanced or metastatic DTC who have progressed following prior therapy and the first approval in pediatric patients with DTC. The approval was based on data from COSMIC-311 (Study XL184-311, NCT03690388), an international, randomized, double-blind trial in which patients with locally advanced or metastatic RAI-refractory DTC that progressed during or following treatment with at least one VEGFR-targeting tyrosine kinase inhibitor (TKI) were treated with either cabozantinib 60 mg orally once daily (N=170) or placebo with best supportive care (N=88). The primary efficacy outcome measures were progression-free survival (PFS) and overall response rate (ORR) by blinded independent central review (BICR) per Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 criteria. The median PFS was 11.0 months (95% CI: 7.4, 13.8) in the cabozantinib arm compared to 1.9 months (95% CI 1.9, 3.7) in the control arm, with a hazard ratio (HR) of 0.22 (95% CI: 0.15, 0.31). The endpoint of ORR was not met. No new safety signals were identified with the exception of hypocalcemia which was added as a warning in the product labeling.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.CCR-22-0873DOI Listing
June 2022

Alterations and Mechanism of Gut Microbiota in Graves' Disease and Hashimoto's Thyroiditis.

Pol J Microbiol 2022 Jun 9;71(2):173-189. Epub 2022 Jun 9.

Department of Rheumatology and Immunology, Xiang'an Hospital of Xiamen University, Xiamen, China.

To explore the role of gut microbiota in Graves' disease (GD) and Hashimoto's thyroiditis (HT). Seventy fecal samples were collected, including 27 patients with GD, 27 with HT, and 16 samples from healthy volunteers. Chemiluminescence was used to detect thyroid function and autoantibodies (FT3, FT4, TSH, TRAb, TGAb, and TPOAb); thyroid ultrasound and 16S sequencing were used to analyze the bacteria in fecal samples; KEGG (Kyoto Encyclopedia of Genes and Genomes) and COG (Clusters of Orthologous Groups) were used to analyze the functional prediction and pathogenesis. The overall structure of gut microbiota in the GD and HT groups was significantly different from the healthy control group. Proteobacteria and Actinobacteria contents were the highest in the HT group. Compared to the control group, the GD and HT groups had a higher abundance of Erysipelotrichia, Cyanobacteria, and _2 and lower levels of and . Further analysis of KEGG found that the "ABC transporter" metabolic pathway was highly correlated with the occurrence of GD and HT. COG analysis showed that the GD and HT groups were enriched in carbohydrate transport and metabolism compared to the healthy control group but not in amino acid transport and metabolism. Our data suggested that , , and could be used as potential markers to distinguish GD and HT from the healthy population and that "ABC transporter" metabolic pathway may be involved in the pathogenesis of GD and HT.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.33073/pjm-2022-016DOI Listing
June 2022

Organic Compound Synthetic Accessibility Prediction Based on the Graph Attention Mechanism.

J Chem Inf Model 2022 Jun 8;62(12):2973-2986. Epub 2022 Jun 8.

Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, Zhejiang, P. R. China.

Accurate estimation of the synthetic accessibility of small molecules is needed in many phases of drug discovery. Several expert-crafted scoring methods and descriptor-based quantitative structure-activity relationship (QSAR) models have been developed for synthetic accessibility assessment, but their practical applications in drug discovery are still quite limited because of relatively low prediction accuracy and poor model interpretability. In this study, we proposed a data-driven interpretable prediction framework called GASA (Graph Attention-based assessment of Synthetic Accessibility) to evaluate the synthetic accessibility of small molecules by distinguishing compounds to be easy- (ES) or hard-to-synthesize (HS). GASA is a graph neural network (GNN) architecture that makes self-feature deduction by applying an attention mechanism to automatically capture the most important structural features related to synthetic accessibility. The sampling around the hypothetical classification boundary was used to improve the ability of GASA to distinguish structurally similar molecules. GASA was extensively evaluated and compared with two descriptor-based machine learning methods (random forest, RF; eXtreme gradient boosting, XGBoost) and four existing scores (SYBA: SYnthetic Bayesian Accessibility; SCScore: Synthetic Complexity score; RAscore: Retrosynthetic Accessibility score; SAscore: Synthetic Accessibility score). Our analysis demonstrates that GASA achieved remarkable performance in distinguishing similar molecules compared with other methods and had a broader applicability domain. In addition, we show how GASA learns the important features that affect molecular synthetic accessibility by assigning attention weights to different atoms. An online prediction service for GASA was offered at http://cadd.zju.edu.cn/gasa/.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jcim.2c00038DOI Listing
June 2022

Application of Bioprinting in Ophthalmology.

Int J Bioprint 2022 22;8(2):552. Epub 2022 Feb 22.

National Traditional Chinese Medicine Clinical Research Base, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China.

Three-dimensional (3D) bioprinting is an emerging technology that is widely used in regenerative medicine. With the continuous development of the technology, it has attracted great attention and demonstrated promising prospects in ophthalmologic applications. In this paper, we review the three main types of 3D bioprinting technologies: Vat polymerization-based bioprinting, extrusion-based bioprinting, and jetting-based bioprinting. We also present in this review the analysis of the usage of both natural and synthesized hydrogels as well as the types of cells adopted for bioinks. Cornea and retina are the two main types of ocular tissues developed in bioprinting, while other device and implants were also developed for the ocular disease treatment. We also summarize the advantages and limitations as well as the future prospects of the current bioprinting technologies based on systematic reviews.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.18063/ijb.v8i2.552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9159480PMC
February 2022

Sign-singularity solution in single-frame speckle interferometry with vortex-phase modulation.

Opt Lett 2022 Jun;47(11):2927-2930

We propose a sign-singularity solution in single-shot digital speckle interferometry based on vortex-phase modulation. The vortex phase is introduced through the reference beam as variation information by a reflective liquid crystal spatial light modulator. The sign singularity is eliminated with the help of a single spiral speckle fringe pattern. To effectively obtain the deformation phase, the measurement process is specially designed on the consideration of the modulation principle of the vortex phase, which is discussed in terms of theoretical analysis and simulation results. Experiments on out-of-plane deformation measurement reveal the feasibility of the proposed method and suggest the potential in actual dynamic measurement applications.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1364/OL.458593DOI Listing
June 2022

SND1 acts as a functional target of miR-330-5p involved in modulating the proliferation, apoptosis and invasion of colorectal cancer cells.

Biochem Biophys Res Commun 2022 Jul 14;615:116-122. Epub 2022 May 14.

Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, 610065, China. Electronic address:

MicroRNAs (miRNAs) play a crucial role in cancer progression due to their capability to modulate the expression of various target genes. However, given the heterogeneity of tumor cells, miRNAs have been confirmed to exert different regulatory effects. Here, bioinformatic analysis results indicated that expression of miR-330-5p is decreased in colorectal cancer (CRC) tissues and inversely correlated with SND1 expression. Notably, ectopic expression of miR-330-5p restrained tumor cell proliferation, migration, and enhance the sensitivity of CRC cells to 5-FU. Moreover, similar phenotypes were substantiated after inhibition of SND1 expression using RNA interference. Conversely, overexpression of SND1 facilitated the malignant phenotypes of CRC cells and restored miR-330-5p-mediated tumor-suppressive activities in CRC cells. Mechanistically, miR-330-5p directly binds to SND1-3'-untranslated region (3'-UTR), thus involving in inhibiting CRC cells proliferation and invasion and promoting apoptosis. Taken together, miR-330-5p may act as a tumor suppressor by targeting the expression of SND1, suggesting that the miR-330-5p/SND1 axis may be a meaningful regulator for CRC intervention.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2022.05.045DOI Listing
July 2022

Outcomes of simultaneous resection for elderly patients with colorectal liver metastasis: A propensity score matching analysis.

Cancer Med 2022 May 24. Epub 2022 May 24.

Department of Hepatobiliary Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: Evidence on simultaneous resection for elderly patients (age ≥ 70 years) with colorectal liver metastasis (CRLM) is lacking.

Methods: Four hundred and eighty-two CRLM patients treated by simultaneous resection were categorised into young group (age < 70 years) and elderly group (age ≥ 70 years). Propensity score matching (PSM1) was performed to adjust for differences in baseline characteristics and compare short-term outcomes. An additional propensity score matching (PSM2) including short-term outcomes was performed to analyse survival. Subgroup analysis was performed in patients stratified by the Clinical Risk Score (CRS).

Results: After PSM1, 87 young group patients were matched to 50 elderly group patients. Patients in the elderly group had a significantly higher rate of overall post-operative complications (68.0% vs. 46.0%, p = 0.013). After PSM2, 89 young group patients were matched to 47 elderly group patients. Progression-free survival (PFS) was comparable between the two groups (median 11.0 months vs. 9.8 months, p = 0.346). Age ≥ 70 independently predicted worse overall survival (OS) (Hazard ratio, HR = 2.57, 95% confidence interval, CI 1.37-4.82) in multivariate analysis. In the subgroup multivariate analysis of patients with CRS score 3-5, age ≥ 70 was independently associated with worse PFS (HR = 1.62, 95% CI 1.01-2.62) and OS (HR = 2.34, 95% CI 1.26-4.35).

Conclusions: Simultaneous resection for elderly CRLM patients is acceptable. Further studies are required to determine the optimal treatment for elderly CRLM patients with high CRS scores.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/cam4.4826DOI Listing
May 2022

Function and regulation of GPX4 in the development and progression of fibrotic disease.

J Cell Physiol 2022 May 23. Epub 2022 May 23.

School of Nursing, Hengyang Medical School, University of South China, Hengyang, Hunan, China.

Fibrosis is a common feature of fibrotic diseases that poses a serious threat to global health due to high morbidity and mortality in developing countries. There exist some chemical compounds and biomolecules associated with the development of fibrosis, including cytokines, hormones, and enzymes. Among them, glutathione peroxidase 4 (GPX4), as a selenoprotein antioxidant enzyme, is widely found in the embryo, testis, brain, liver, heart, and photoreceptor cells. Moreover, it is shown that GPX4 elicits diverse biological functions by suppressing phospholipid hydroperoxide at the expense of decreased glutathione (GSH), including loss of neurons, autophagy, cell repair, inflammation, ferroptosis, apoptosis, and oxidative stress. Interestingly, these processes are intimately related to the occurrence of fibrotic disease. Recently, GPX4 has been reported to exhibit a decline in fibrotic disease and inhibit fibrosis, suggesting that alterations of GPX4 can change the course or dictate the outcome of fibrotic disease. In this review, we summarize the role and underlying mechanisms of GPX4 in fibrosis diseases such as lung fibrosis, liver fibrosis, kidney fibrosis, cardiac fibrosis, and myelofibrosis.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcp.30780DOI Listing
May 2022

Self-organizing map based differential evolution with dynamic selection strategy for multimodal optimization problems.

Math Biosci Eng 2022 Apr;19(6):5968-5997

South China University of Technology, the School of Computer Science and Engineering, Guangzhou 510006, China.

Many real-world problems can be classified as multimodal optimization problems (MMOPs), which require to locate global optima as more as possible and refine the accuracy of found optima as high as possible. When dealing with MMOPs, how to divide population and obtain effective niches is a key to balance population diversity and convergence during evolution. In this paper, a self-organizing map (SOM) based differential evolution with dynamic selection strategy (SOMDE-DS) is proposed to improve the performance of differential evolution (DE) in solving MMOPs. Firstly, a SOM based method is introduced as a niching technique to divide population reasonably by using the similarity information among different individuals. Secondly, a variable neighborhood search (VNS) strategy is proposed to locate more possible optimal regions by expanding the search space. Thirdly, a dynamic selection (DS) strategy is designed to balance exploration and exploitation of the population by taking advantages of both local search strategy and global search strategy. The proposed SOMDE-DS is compared with several widely used multimodal optimization algorithms on benchmark CEC'2013. The experimental results show that SOMDE-DS is superior or competitive with the compared algorithms.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3934/mbe.2022279DOI Listing
April 2022

Predicting the Stone-Free Status of Percutaneous Nephrolithotomy With the Machine Learning System: Comparative Analysis With Guy's Stone Score and the S.T.O.N.E Score System.

Front Mol Biosci 2022 4;9:880291. Epub 2022 May 4.

Zhongshan Hospital, Fudan University, Shanghai, China.

The aim of the study was to use machine learning methods (MLMs) to predict the stone-free status after percutaneous nephrolithotomy (PCNL). We compared the performance of this system with Guy's stone score and the S.T.O.N.E score system. Data from 222 patients (90 females, 41%) who underwent PCNL at our center were used. Twenty-six parameters, including individual variables, renal and stone factors, and surgical factors were used as input data for MLMs. We evaluated the efficacy of four different techniques: Lasso-logistic (LL), random forest (RF), support vector machine (SVM), and Naive Bayes. The model performance was evaluated using the area under the curve (AUC) and compared with that of Guy's stone score and the S.T.O.N.E score system. The overall stone-free rate was 50% (111/222). To predict the stone-free status, all receiver operating characteristic curves of the four MLMs were above the curve for Guy's stone score. The AUCs of LL, RF, SVM, and Naive Bayes were 0.879, 0.803, 0.818, and 0.803, respectively. These values were higher than the AUC of Guy's score system, 0.800. The accuracies of the MLMs (0.803% to 0.818%) were also superior to the S.T.O.N.E score system (0.788%). Among the MLMs, Lasso-logistic showed the most favorable AUC. Machine learning methods can predict the stone-free rate with AUCs not inferior to those of Guy's stone score and the S.T.O.N.E score system.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fmolb.2022.880291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9114350PMC
May 2022

Preoperative Concurrent Chemoradiotherapy Versus Neoadjuvant Chemotherapy for Locally Advanced Gastric Cancer: Phase II Randomized Study.

Front Oncol 2022 29;12:870741. Epub 2022 Apr 29.

Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Objective: We evaluated and compared the efficacy and safety of neoadjuvant chemoradiotherapy (NACRT) versus neoadjuvant chemotherapy (NACT) for locally advanced gastric cancer (LAGC) in a single-center randomized phase II trial.

Methods: Patients with LAGC were enrolled and received either NACT or NACRT, followed by gastrectomy and adjuvant chemotherapy. The primary endpoint was an R0 resection rate.

Results: We enrolled 75 patients: 75.7% (NACT, 28/37 patients) and 76.3% (NACRT, 29/38 patients) underwent surgery; R0 resection rates were 73.0% (27/37) and 73.7% (28/38), respectively. The NACRT group had significantly better major pathological response than the NACT group (37.9% vs 17.9%, p = 0.019). Between-group postoperative complications were not significantly different. The median follow-up was 59.6 months; 5-year overall survival (OS) rate was 50.1% (NACT) and 61.9% (NACRT); neither group reached the median OS; median progression-free survival was 37.3 and 63.4 months, respectively.

Conclusions: S-1-based NACRT did not improve the R0 resection rate, although it presented better tumor regression with similar safety to NACT.

Trial Registration: ClinicalTrial.gov NCT02301481.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fonc.2022.870741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9104815PMC
April 2022

Serum alpha-fetoprotein as a predictive biomarker for tissue alpha-fetoprotein status and prognosis in patients with hepatocellular carcinoma.

Transl Cancer Res 2022 Apr;11(4):669-677

Department of Hepatobiliary Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: Alpha-fetoprotein (AFP) expression is closely related to hepatocarcinogenesis, and it is an important prognostic factor for hepatocellular carcinoma (HCC). We aimed to investigate the relationship between serum AFP concentration and tissue AFP status and identify the prognostic value of serum and tissue AFP for HCC.

Methods: This is a retrospective review of 248 patients with HCC from January 2012 to December 2018. Receiver operating characteristic (ROC) curves were plotted to investigate the predictive value of serum AFP for tissue AFP status. Overall survival (OS) was analyzed using the Kaplan-Meier method and log-rank tests were used for comparison between two groups. Multivariate Cox proportional hazards regression analysis was performed for various risk factors.

Results: The serum AFP level in patients with tissue AFP-positive HCC was higher than those with tissue AFP-negative HCC (506.7 7.7 ng/mL, P<0.0001). Youden's index yielded an optimal cut-off value of serum AFP for tissue AFP status of 92.33 ng/mL with a sensitivity and specificity of 0.84 (95% CI: 0.74-0.90) and 0.88 (95% CI: 0.82-0.92), respectively. Moreover, high serum AFP concentrations (≥92.33 ng/mL) were significantly correlated with positive hepatitis B virus (HBV, P=0.012), tumor size (P=0.025) and histological grade (P=0.001); tissue AFP-positive status was associated with positive HBV (P=0.006), tumor number (P=0.033) and histological grade (P<0.001). Further, serum AFP level ≥92.33 ng/mL and tissue AFP-positive status were associated with poorer OS, and positive HBV (Positive: HR 3.496; 95% CI: 1.349-9.064; P=0.010) and larger tumor size (≥5; HR 2.617; 95% CI: 1.372-4.992; P=0.003) were independent factors of OS.

Conclusions: This study showed that serum AFP level could be a highly predictive biomarker for tissue AFP status in patients with HCC. Furthermore, serum AFP levels ≥92.33 ng/mL and tissue AFP-positive status were associated with poorer OS but were not independent factors of OS.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.21037/tcr-21-2334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9091006PMC
April 2022

Cross-Talk between Transcriptome Analysis and Physiological Characterization Identifies the Genes in Response to the Low Phosphorus Stress in .

Int J Mol Sci 2022 Apr 28;23(9). Epub 2022 Apr 28.

Key Laboratory of Plant Resource Conservation and Germplasm Innovation in Mountainous Region (Ministry of Education), Institute of Agro-Bioengineering/College of Life Sciences, Guizhou University, Guiyang 550025, China.

Phosphorus (Pi) is a macronutrient essential for plant growth, development, and reproduction. However, there is not an efficient available amount of Pi that can be absorbed by plants in the soil. Previously, an elite line, MSDZ 109, selected from , was justified for its excellent tolerance to low phosphorus (low-Pi) stress. To date, however, the genes involved in low-Pi stress tolerance have not yet been unraveled in this species. Currently, the physiological responses of this line for different days to low-Pi stress were characterized, and their roots as well as leaves were used to carry out transcriptome analysis, so as to illuminate the potential molecular pathways and identify the genes involved in low-Pi stress-response. After exposure to low-Pi treatment (32 µmol/L KHPO) for 20 day after treatment (DAF) the biomass of shoots was significantly reduced in comparison with that of the stress-free (control), and root architecture diversely changed. For example, the root growth parameters e.g., length, surface area, and total volume somewhat increase in comparison with those of the control. The activity of acid phosphatase (ACP) increased with the low-Pi treatment, whereas the photosynthetic rate and biomass were declining. The activity of antioxidant enzymes, e.g., superoxide dismutase (SOD), peroxidase (POD), and catalase (CAT), were substantially elevated in response to low-Pi treatment. Many enzyme-related candidate genes e.g., , and were up-regulated to low-Pi treatment. Furthermore, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis indicated that the processes of photosynthesis, plant hormone signal transduction, and MAPK signaling pathway were affected in the low-Pi response. In combination with the physiological characterization, several low-Pi-responsive genes, e.g., PHT, PHO, were identified, and the genes implicated in Pi uptake and transport, such as , , , etc., were also obtained since their expression status varied among the exposure times, which probably notifies the candidates involved in low-Pi-responsive tolerance in this line. Interestingly, low-Pi treatment activated the expression of transcription factors including the WRKY family, MYB family, etc. The available evidences will facilitate a better understanding of the roles of this line underlying the high tolerance to low-Pi stress. Additionally, the accessible data are helpful for the use of the apple rootstock under low-Pi stress.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms23094896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9105917PMC
April 2022

Effects of silver foam combined with Dermlin wound healing dressing on inflammation and quality of life in patients with diabetic lower limb ulcers.

Am J Transl Res 2022 15;14(4):2452-2460. Epub 2022 Apr 15.

Wound Stoma Care Outpatient Center, The First Affiliated Hospital of Anhui Medical University Hefei 230022, Anhui, China.

Objective: To investigate the effects of silver foam combined with Dermlin wound healing dressing on concentrations of inflammatory factors of wound surface and quality of life of the patients with diabetic lower limb ulcers.

Methods: A total of 60 patients with diabetic lower limb ulcers admitted to the First Affiliated Hospital of Anhui Medical University during January 2020 and December 2020 were retrospectively enrolled in this study. According to the different treatments, they were divided into a control group (30 cases treated with Dermlin wound healing dressing only), and a research group (30 cases treated with silver foam combined with Dermlin dressing). The clinical efficacy, wound healing status, pain intensity (visual analog scale (VAS) scores), concentrations of inflammatory factor (high-sensitivity C-reactive protein (hsCRP), leukocyte interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), procalcitonin (PCT)), angiogenesis factors levels (basic fibroblast growth factor (BFGF), vascular endothelial growth factor (VEGF)), oxidative stress reaction indexes (advanced protein oxidation products (AOPP), malondialdehyde (MDA) and superoxide dismutase (SOD)) and quality of life (SF-36 scale) were compared between two groups. The bacterial removal rate was calculated based on the results of bacterial culture before and after treatment. The central granulated tissue was collected after the granulation tissue coverage rate was calculated.

Results: The research group had significantly higher overall response rate (96.67% vs 73.33%), shorter wound healing time and higher wound healing rate than the control group (all P<0.05). The VAS scores were decreased in both Groups 1, 3 and 7 d after treatment as compared with those before treatment, and the VAS scores were significantly lower in the research group than in the control group during the same period (all P<0.05). After treatment, the concentrations of hsCRP, IL-6, TNF-α, PCT, AOPP and MDA were decreased in both groups, while the levels of bFGF, VEGF, l TGF-β1, SOD and SF-36 scores were increased significantly (all P<0.05). The above-mentioned indicators of the research group improved significantly compared with those of the control group (all P<0.05). The bacterial removal rate and granulation tissue coverage rate of the research group were significantly higher than those of the control group (both P<0.05).

Conclusion: The treatment of diabetic lower limb ulcers with silver foam combined with Dermlin dressing can effectively promote wound healing, reduce pain intensity, and improve quality of life in patients with diabetic lower limb ulcers. Such effects may be attributed to lower levels of inflammatory factor levels, regulation of oxidative stress, and improvement of angiogenesis.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9091129PMC
April 2022

The Effects of Infection on Gastric Microbiota in Children With Duodenal Ulcer.

Front Microbiol 2022 25;13:853184. Epub 2022 Apr 25.

Department of Gastroenterology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children's Regional Medical Center, Hangzhou, China.

Background: () infection is the main cause of chronic gastritis and duodenal ulcer in children. Little is known about the effect of on gastric microbiota in children with duodenal ulcer. This study is aimed at the characteristics of gastric microbiota in children with duodenal ulcer on infection.

Methods: We studied 23 children diagnosed with duodenal ulcer by gastric endoscopy because of the gastrointestinal symptoms, 15 children were diagnosed with infection, while 8 children were without infection. Endoscopic mucosal biopsy samples were obtained for DNA extraction. Microbiomes were analyzed by 16S rRNA profiling and microbial functions were predicted using the software Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt).

Results: Bacterial richness and diversity of gastric microbiota in duodenal ulcer with -positive were lower than those negative. The gastric microbiota in -positive group significantly reduced proportions of six phyla and fifteen genera; only taxa were more abundant in positive group. Co-expression network analysis showed a more complex network of interactions in the positive group than that in the negative group. For the predicted functions, lower abundance in the pathways of carbohydrate metabolism, signal transduction, amino acid metabolism, and lipid metabolism were found in positive group than the negative group. colonization reduces a microbial community with genotoxic potential in the gastric mucosa of children with duodenal ulcer.

Conclusions: The presence of significantly influences gastric microbiota and results in a lower abundance of multiple taxonomic levels in children with duodenal ulcer. Children with duodenal ulcer exhibit a dysbiotic microbial community with genotoxic potential, which is distinct from that of children with infection.

Clinical Trial Registration: [http://www.chictr.org.cn], identifier [ChiCTR1800015190].
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fmicb.2022.853184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9082302PMC
April 2022

A Wearable Gait Analysis and Recognition Method for Parkinson's Disease Based on Error State Kalman Filter.

IEEE J Biomed Health Inform 2022 May 11;PP. Epub 2022 May 11.

Introduction: For the purpose of quantitative analysis, this paper proposes a wearable gait analysis method for Parkinson's disease (PD) to evaluates the motor ability.

Methods: The error state Kalman filter (ESKF) is used for attitude update, and the gait parameters are modified by phase segmentation and zero velocity update (ZUPT) algorithm. In addition, this study uses gait parameters as classifier features to recognize abnormal gait, and compares the recognition effect with statistical features.

Results: The effect of our gait system is verified by comparison with the OptiTrack system, and the mean absolute error (MAE) of step length and foot clearance are 2.523.61cm and 0.961.24cm respectively. Forty Parkinson's patients and forty age-matched healthy people are recruited for gait comparison, the analysis results showed significant differences between the two groups. The abnormal gait recognition results show that gait features have stronger generalization ability than statistical features in leave-one-subject-out (LOSO) validation.

Conclusion: The method proposed in this study can be applied to the gait analysis and objective evaluation of PD.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1109/JBHI.2022.3174249DOI Listing
May 2022

Deterministic control of ferroelectric polarization by ultrafast laser pulses.

Nat Commun 2022 May 10;13(1):2566. Epub 2022 May 10.

Physics Department and Institute for Nanoscience and Engineering, University of Arkansas, Fayetteville, AR, 72701, USA.

Ultrafast light-matter interactions present a promising route to control ferroelectric polarization at room temperature, which is an exciting idea for designing novel ferroelectric-based devices. One emergent light-induced technique for controlling polarization consists in anharmonically driving a high-frequency phonon mode through its coupling to the polarization. A step towards such control has been recently accomplished, but the polarization has been reported to be only partially reversed and for a short lapse of time. Such transient partial reversal is not currently understood, and it is presently unclear if full control of polarization, by, e.g., fully reversing it or even making it adopt different directions (thus inducing structural phase transitions), can be achieved by activating the high-frequency phonon mode via terahertz pulse stimuli. Here, by means of realistic simulations of a prototypical ferroelectric, we reveal and explain (1) why a transient partial reversal has been observed, and (2) how to deterministically control the ferroelectric polarization thanks to these stimuli. Such results can provide guidance for realizing original ultrafast optoferroic devices.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-022-30324-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9090784PMC
May 2022

Research on Video Captioning Based on Multifeature Fusion.

Comput Intell Neurosci 2022 28;2022:1204909. Epub 2022 Apr 28.

School of Computer and Communication, Lanzhou University of Technology, Lanzhou, Gansu, China.

Aiming at the problems that the existing video captioning models pay attention to incomplete information and the generation of expression text is not accurate enough, a video captioning model that integrates image, audio, and motion optical flow is proposed. A variety of large-scale dataset pretraining models are used to extract video frame features, motion information, audio features, and video sequence features. An embedded layer structure based on self-attention mechanism is designed to embed single-mode features and learn single-mode feature parameters. Then, two schemes of joint representation and cooperative representation are used to fuse the multimodal features of the feature vectors output by the embedded layer, so that the model can pay attention to different targets in the video and their interactive relationships, which effectively improves the performance of the video captioning model. The experiment is carried out on large datasets MSR-VTT and LSMDC. Under the metrics BLEU4, METEOR, ROUGEL, and CIDEr, the MSR-VTT benchmark dataset obtained scores of 0.443, 0.327, 0.619, and 0.521, respectively. The result shows that the proposed method can effectively improve the performance of the video captioning model, and the evaluation indexes are improved compared with comparison models.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1155/2022/1204909DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9071958PMC
May 2022

Different Radiological Criteria for Early Tumor Response Evaluation in Patients With Unresectable Hepatocellular Carcinoma Treated With Anti-PD-1 Antibody Plus Bevacizumab.

Front Oncol 2022 19;12:848129. Epub 2022 Apr 19.

Department of Diagnostic Radiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Purpose: We aimed to compare different radiological criteria in evaluating the early tumor response of patients with unresectable hepatocellular carcinoma (uHCC) treated with an anti-programmed cell death protein 1 (PD-1) antibody plus bevacizumab.

Method: From October 2018 to January 2020, 58 patients [49 (84.5%) men, age = 55.2 ± 10.6 years] receiving both anti-PD-1 antibody and bevacizumab were retrospectively included. Pre- and the first posttreatment contrast-enhanced computed tomography (CE-CT) scans were performed in all patients. The Response Evaluation Criteria in Solid Tumors, version 1.1 (RECIST 1.1), modified RECIST (mRECIST), Choi, and the revised Choi (rChoi) criteria were applied to evaluate tumor response. The endpoint event was defined as overall survival (OS).

Results: Six (10.3%), 9 (15.5%), 30 (51.7%), and 12 (20.7%) patients were diagnosed as responders by RECIST 1.1, mRECIST, Choi, and rChoi, respectively. The RECIST 1.1 and mRECIST criteria failed to correlate the evaluation categories with OS ( = 0.130 and 0.253, respectively), while both Choi and rChoi significantly correlated with OS ( = 0.002 and 0.006, respectively). Among the four criteria, only those patients identified as responders by Choi ( = 0.0005) and rChoi ( = 0.005) showed significantly better OS than the non-responders. The cumulative 1- and 2-year OS rates by Choi were 93.3% and 79.8% in responders and 69.3% and 30.3% in non-responders, respectively; these rates were 100.0% and 100.0% in responders and 74.9% and 43.1% in non-responders by rChoi, respectively.

Conclusions: The evaluation of early tumor response using Choi and rChoi instead of RECIST 1.1 and mRECIST significantly correlated with the OS of patients with uHCC treated with an anti-PD-1 antibody plus bevacizumab. Moreover, patients identified as responders by Choi and rChoi showed significantly better OS than the non-responders.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fonc.2022.848129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9063040PMC
April 2022

Correction: the characteristics of video capsule endoscopy in pediatric Henoch-Schönlein purpura with gastrointestinal symptoms.

Pediatr Rheumatol Online J 2022 May 2;20(1):33. Epub 2022 May 2.

Department of gastroenterology, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, 3333 Bin Sheng Road, Hangzhou, 310052, Zhejiang Province, China.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12969-022-00683-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9063330PMC
May 2022

Video captioning based on vision transformer and reinforcement learning.

PeerJ Comput Sci 2022 16;8:e916. Epub 2022 Mar 16.

Network & Information Center, Lanzhou University of Technology, Lanzhou, Gansu, China.

Global encoding of visual features in video captioning is important for improving the description accuracy. In this paper, we propose a video captioning method that combines Vision Transformer (ViT) and reinforcement learning. Firstly, Resnet-152 and ResNeXt-101 are used to extract features from videos. Secondly, the encoding block of the ViT network is applied to encode video features. Thirdly, the encoded features are fed into a Long Short-Term Memory (LSTM) network to generate a video content description. Finally, the accuracy of video content description is further improved by fine-tuning reinforcement learning. We conducted experiments on the benchmark dataset MSR-VTT used for video captioning. The results show that compared with the current mainstream methods, the model in this paper has improved by 2.9%, 1.4%, 0.9% and 4.8% under the four evaluation indicators of LEU-4, METEOR, ROUGE-L and CIDEr-D, respectively.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.7717/peerj-cs.916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9044334PMC
March 2022
-->