Publications by authors named "Hong Guo"

816 Publications

A Tiered Genetic Screening Strategy for the Molecular Diagnosis of Intellectual Disability in Chinese Patients.

Front Genet 2021 23;12:669217. Epub 2021 Sep 23.

Department of Medical Genetics, College of Basic Medical Science, Army Medical University, Chongqing, China.

Intellectual disability (ID) is one of the most common developmental disabilities. To identify the genetic etiology of IDs in Chongqing, we conducted a multistage study in Chinese Han patients. We collected the clinical and etiological data of 1665 ID patients, including 1,604 from the disabled children evaluation center and 61 from the pediatric rehabilitation unit. Routine genetic screening results were obtained, including karyotype and candidate gene analysis. Then 105 idiopathic cases with syndromic and severe ID/developmental delay (DD) were selected and tested by chromosomal microarray (CMA) and whole exome sequencing (WES) sequentially. The pathogenicity of the CNVs and SNVs were evaluated according to ACMG guidelines. Molecular diagnosis was made by routine genetic screening in 216 patients, including 196 chromosomal syndromes. Among the 105 idiopathic patients, 49 patients with pathogenic/likely pathogenic CNVs and 21 patients with VUS were identified by CMA. Twenty-six pathogenic CNVs underlying well-known syndromic cases, such as Williams-Beuren syndrome, were confirmed by multiplex ligation-dependent probe amplification (MLPA). Nine novel mutations were identified by WES in thirty-fix CNV-negative ID cases. The study illustrated the genetic aberrations distribution of a large ID cohort in Chongqing. Compared with conventional or single methods, a tiered high-throughput diagnostic strategy was developed to greatly improve the diagnostic yields and extend the variation spectrum for idiopathic syndromic ID cases.
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http://dx.doi.org/10.3389/fgene.2021.669217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8495063PMC
September 2021

Moiré patterns of twisted bilayer antimonene and their structural and electronic transition.

Nanoscale 2021 Aug 29;13(31):13427-13436. Epub 2021 Jul 29.

Department of Physics, McGill University, 3600 Rue University, Montréal, Québec H3A 2 T8, Canada.

Interlayer twisting in two-dimensional (2D) van der Waals (vdW) heterostructures often leads to a periodic moiré pattern which is a superlattice structure on top of the original atomic lattice of the 2D layers. The formation of a moiré superlattice can be accompanied by a significant structural reconstruction and ultra-flat electronic bands. The moiré superlattice is typically built with a tunable scale by controlling the rotation angle θ between the individual 2D layers. In this paper, we report the structural reconstruction and electronic transition in moiré patterns of twisted bilayer antimonene, based on Kohn-Sham density functional theory calculations. Starting from rigid moiré structures, the atomic relaxation leads to an array of high-symmetry stacking domains with soliton boundaries through a vortex-like reconstruction. For twist angle θ≤ 6.01°, the impact of the structural reconstruction on the electronic bands becomes very significant, in the appearance of flat bands at the valence band edge, and no magic angle is required for the flat bands to appear in the 2D Sb moiré patterns. Both inhomogeneous interlayer hybridization and local strain are found to be responsible for the formation of these flat electronic bands.
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http://dx.doi.org/10.1039/d1nr02843jDOI Listing
August 2021

Augmented renal clearance in Chinese intensive care unit patients after traumatic brain injury: a cross-sectional study.

Chin Med J (Engl) 2021 Aug 17. Epub 2021 Aug 17.

Department of Pharmacy, The First Hospital of Lanzhou University, Lanzhou, Gansu 730000, China Department of Critical Care Medicine, The First Hospital of Lanzhou University, Lanzhou, Gansu 730000, China Department of Neurosurgery, The First Hospital of Lanzhou University, Lanzhou, Gansu 730000, China.

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http://dx.doi.org/10.1097/CM9.0000000000001572DOI Listing
August 2021

[Dynamic comparisons of epicardial electrograms between the left atrium and pulmonary veins in atrial fibrillation in goat model].

Zhongguo Ying Yong Sheng Li Xue Za Zhi 2021 May;37(3):235-239

Department of Cardiology, 1st Medical Center, General Hospital of PLA, Beijing 100853, China.

To compare epicardial electrograms between the left atrium (LA) and pulmonary veins (PVs) dynamically at development of persistent atrial fibrillation(AF) in goats PVs. Ten female goats were instrumented with electrodes at the LA and left side PV. Sustained AF (>24 h) was induced in the goat by rapid intermittent left atrial pacing for(9.5±2.3)days at a pacing interval of 20 ms for 1 s with a maximum output of 6.0 V, followed by a 2-s period without pacing. Characteristics of PVs and LA epicardial electrograms were analyzed in the development of AF. With prolonged stimulation, the duration of AF was prolonged, complex fractionated atrial electrograms(CFAEs) in LA and was increased gradually, PVs had more CFAEs than LA all the time. When induced AF lasted for more than 24 h, CFAEs in PVs became sustained approximately (2.7%±3.6% 92.6%±6.4%, at onset of AF AF lasted for more than 24 h, <0.05), and the ratio of CFAEs in PVs was more than that in LA (92.6%±6.4% 72.8%±5.3%, <0.05). The epicardial CFAEs are in specific area, which increase along with electrical remodeling. The epicardial CFAEs may play an important role in the maintenance of AF in this model.
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http://dx.doi.org/10.12047/j.cjap.6037.2021.011DOI Listing
May 2021

Duzhong Fang Attenuates the POMC-Derived Neuroinflammation in Parkinsonian Mice.

J Inflamm Res 2021 23;14:3261-3276. Epub 2021 Jul 23.

State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, People's Republic of China.

Background: Neuroinflammation and microglia reactivity are now recognized to be features of Parkinson's disease (PD). Thus, microglia phenotype is a potential new target for developing treatments against PD. Duzhong Fang (DZF) is a traditional Chinese medicine (TCM) prescription. The theory of TCM argues that Duzhong Fang, nourishing yin and tonifying yang, may treat PD. However, its modern pharmacological studies and the underlying mechanisms are unclear.

Methods: First, MPTP was used to establish a parkinsonian mouse model, and behavioral testing was used to evaluate the locomotor dysfunction. Then, HPLC, immunohistochemical staining, and Western blot assays were performed to evaluate the survival of dopaminergic neurons. Molecular biological and immunofluorescence staining were used to evaluate the neuroinflammation and microglial activation. In addition, RNA-seq transcriptomics was used to analyze differentially expressed genes and verify by RT-PCR.

Results: In the present study, we first confirmed that DZF can alleviate neuroinflammation and ameliorate dyskinesia in parkinsonian mice. Then, further studies found that DZF can regulate microglial morphology and reactivity and act on the POMC gene. POMC is an upstream target for regulating inflammation and proinflammatory cytokines, and DZF can directly inhibit the POMC level and restore the homeostatic signature of microglia in parkinsonian mice.

Conclusion: This study found that POMC may have a potential role as a therapeutic target for PD. DZF may inhibit neuroinflammation and play an anti-PD effect by down-regulating the expression of POMC.
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http://dx.doi.org/10.2147/JIR.S316314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8315774PMC
July 2021

Reliability and validity of the Chinese version of the Head and Neck Information Needs Questionnaire for patients with head and neck cancer and their caregivers.

Int J Nurs Sci 2021 Jul 6;8(3):354-360. Epub 2021 Jun 6.

School of Nursing, Beijing University of Chinese Medicine, Beijing, China.

Objectives: This study aimed to assess the reliability and validity of the Chinese version of the Head and Neck Information Needs Questionnaire (HaNiQ).

Methods: The HaNiQ was translated into a Chinese version using internationally recognized forward- and back-translation procedures. The reliability and validity of the HaNiQ were measured using Cronbach's α coefficient, split-half reliability, exploratory factor analysis, and Pearson correlation analysis.

Results: A total of 207 patients in different head and neck cancer (HNC) stages and 174 caregivers completed the Chinese version of the HaNiQ. Internal consistencies varied between good and very well (Cronbach's α coefficient 0.74-0.90); the split-half coefficient and the content validity index (CVI) of the questionnaire were 83.5% and 83.33%, respectively. The cumulative contribution rates of the 5 subscales in patients with HNCand their caregivers were 62.41% and 61.19%, respectively. However, there are some differences between the Chinese questionnaire for caregiver and the original questionnaire regarding the attribution of items. Items 22, 23, and 27 in the Psychosocial subscale of the English version were assigned to the Survivorship subscale in the Chinese version for caregivers.

Conclusions: The results demonstrated that the Chinese version of the HaNiQ is a reliable and valid instrument for measuring the information needs of patients with HNC and that of their caregivers. Though the structure of the Chinese version was different from the English version for caregivers of HNC patients, the Chinese version of the HaNiQ appears to be reliable and would benefit from further testing.
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http://dx.doi.org/10.1016/j.ijnss.2021.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8283703PMC
July 2021

Sesquiterpene biosynthesis in a leafy liverwort Radula lindenbergiana Gottsche ex C. Hartm.

Phytochemistry 2021 Oct 6;190:112847. Epub 2021 Jul 6.

Department of Plant Sciences, University of Tennessee, Knoxville, TN, 37996, USA. Electronic address:

Liverworts (Marchantiophyta) are among the earliest diverging lineages of extant land plants. Among their unique features, most liverworts contain membrane-bound oil bodies, organelles that accumulate diverse secondary metabolites, especially terpenoids. In contrast to the rich information on liverwort terpenoid chemistry, little is known about their biosynthesis. Recently, terpenoid biosynthesis was studied in a model thalloid species Marchantiapolymorpha, in which sesquiterpenes and monoterpenes are biosynthesized by a new type of terpene synthases termed microbial terpene synthase-like (MTPSL) proteins. Here we study terpenoid biosynthesis in a leafy liverwort Radula lindenbergiana. Vegetative plants of R.lindenbergiana were found to contain a mixture of sesquiterpenes, with (E,E)-α-farnesene/β-curcumene and (Z)-β-bisabolene being the most abundant constituents. From the analysis of the R. lindenbergiana transcriptome, five full-length MTPSL genes were identified. They were designated RlMTPSL1-5, respectively. Recombinant RlMTPSL proteins were produced in Escherichia coli and tested for sesquiterpene synthase activities using farnesyl diphosphate (FPP) as substrate. All except RlMTPSL5 were demonstrated to catalyze the formation of different sesquiterpenes. RlMTPSL1 produced multiple sesquiterpenes with eremophilene and an unidentified sesquiterpene as major products. The major products of RlMTPSL2 and RlMTPSL3 were β-elemene and an unidentified sesquiterpene, respectively. RlMTPSL4 was also a multi-product sesquiterpene synthase with an unidentified sesquiterpene being the major product. Homology-based structural modeling was performed to understand the structural basis underlying different product profiles of the RlMTPSLs proteins. Most of the sesquiterpene products of the four active RlMTPSLs were also detected in R. lindenbergiana plants. Expression levels of the four RlMTPSL genes encoding active enzymes in vegetative plants were compared. In phylogenetic analysis, RlMTPSL genes were found to cluster together, indicating lineage-specific expansion of MTPSL genes in lineages leading to R.lindenbergiana and M. polymorpha. This study strengthens evidence for the contribution of MTPSL genes to terpenoid biosynthesis in liverworts.
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http://dx.doi.org/10.1016/j.phytochem.2021.112847DOI Listing
October 2021

IL-9 contributes to the host immune response against Helicobacter pylori and helps limit infection in a Mouse Model.

Helicobacter 2021 Oct 7;26(5):e12827. Epub 2021 Jul 7.

Department of Critical Care Medicine, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.

Background: As an important mediator in lots of diseases, interleukin-9 (IL-9) can be a protector or pro-inflammatory cytokine depending on the complicated inflammatory milieu. Helicobacter pylori (H. pylori) induced a series of immunology cells and cytokines change, and however, the role of IL-9 in H. pylori infection remains unknown.

Materials And Methods: Wild-type and IL-9 deficient mice were infected with H. pylori by means of intragastric administration. The colonization of H. pylori bacteria was measured by detecting specific 16s rDNA, and the intensity of inflammation was observed by H&E stain. The expression level of inflammation cytokines was determined by ELISA and quantitative real-time PCR.

Results: IL-9 was increased due to the attack of H. pylori, besides deletion of Il9 aggravated the bacterial colonization and inflammation intensity. In addition, treatment of rmIL-9 reduced colonized H. pylori and inflammation level, indicated that IL-9 was a protector for the host against this bacterium. Followed by the H. pylori infection, interferon (IFN)-γ and interleukin (IL)-17A were up-regulated as expected, and nevertheless, the expression of IL-17A shared a positive relationship with IL-9 while IFN-γ negative associated with IL-9. Moreover, we also proved that Treg cells were not involved in the protective effect of IL-9, and meanwhile, CD4 CD25 T cells secreted more IFN-γ and less IL-17A in vitro due to the deletion of Il9.

Conclusions: IL-9 plays a protective role against H. pylori and the protection associated with cytokines change including IFN-γ and IL-17A.
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http://dx.doi.org/10.1111/hel.12827DOI Listing
October 2021

Metagenomic analysis of a throat swab sample collected in China on a patient infected with Varicella Zoster Virus.

Sci Rep 2021 07 6;11(1):13874. Epub 2021 Jul 6.

College of Basic Medicine, Inner Mongolia Medical University, Hohhot, 010110, China.

Varicella Zoster Virus (VZV) is endemic worldwide, causing varicella in children and zoster upon reactivation in adults. This study concerned a metagenomic analysis of a throat swab sample collected in China, on a young patient suffering from Systemic Lupus Erythematosus (SLE) and diagnosed with varicella. The complete genome sequence of a VZV strain of clade 2 has been generated. Clade 2 strains are the most prevalent in Asian countries. A comparison of 223 VZV genomes identified 77 clade specific markers, 20 of them specific to clade 2. The metagenomic analysis also identified sequences covering most of the genome of the bacteria Schaalia odontolytica also known as Actinomyces odontolyticus. VZV infection and bacterial infection in the context of SLE is further discussed. Even though the patient presented only mild symptoms, this study is a reminder that vaccination against VZV is critical to avoid severe complications like bacterial superinfection or even death in the case of immunodeficiency.
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http://dx.doi.org/10.1038/s41598-021-93230-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260771PMC
July 2021

Unraveling mechanisms of pentraxin 3 secretion in adipocytes during inflammation.

J Mol Endocrinol 2021 07 26;67(3):55-69. Epub 2021 Jul 26.

Department of Food Science and Nutrition, University of Minnesota, Twin Cities, Minnesota, USA.

Pentraxin 3 (PTX3) is a soluble pattern recognition receptor playing an important role in immune response and inflammation. Lipopolysaccharide (LPS) stimulation can significantly induce PTX3 expression and secretion in adipocytes. Appropriate regulation of PTX3 secretion is critical for inflammatory homeostasis. Using chemical inhibitors of conventional and unconventional protein secretion, we explored the mechanisms that control LPS-stimulated PTX3 secretion in 3T3-L1 adipocytes. Inhibiting the conventional protein secretion blocked LPS-stimulated PTX3 secretion, resulting in cellular PTX3 accumulation in adipocytes. We also detected PTX3 in exosomes from LPS-treated adipocytes; inhibiting exosome trafficking attenuated PTX3 secretion. However, only 4.3% of secreted PTX3 was detected in exosomes compared to 95.7% in the non-exosomal fractions. The fractionation of isolated exosomes by the iodixanol density gradient centrifugation confirmed that a small portion of secreted PTX3 overlapped with exosomal markers in small extracellular-vesicle fractions. We conclude that PTX3 is secreted mainly through conventional protein secretion, and a small percentage of PTX3 is released in exosomes from LPS-stimulated adipocytes.
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http://dx.doi.org/10.1530/JME-21-0026DOI Listing
July 2021

iRGD-liposomes enhance tumor delivery and therapeutic efficacy of antisense oligonucleotide drugs against primary prostate cancer and bone metastasis.

Adv Funct Mater 2021 Jun 10;31(24). Epub 2021 Apr 10.

Department of Pharmaceutics, School of Pharmacy, University of Minnesota, Minneapolis, MN 55455, United States.

Nucleotide-based drugs, such as antisense oligonucleotides (ASOs), have unique advantages in treating human diseases as they provide virtually unlimited ability to target any gene. However, their clinical translation faces many challenges, one of which is poor delivery to the target tissue . This problem is particularly evident in solid tumors. Here, we functionalized liposomes with a tumor-homing and -penetrating peptide, iRGD, as a carrier of an ASO against androgen receptor (AR) for prostate cancer treatment. The iRGD-liposomes exhibited a high loading efficiency of AR-ASO, and an efficient knockdown of AR gene products was achieved , including AR splice variants. , iRGD-liposomes significantly increased AR-ASO accumulation in the tumor tissue and decreased AR expression relative to free ASOs in prostate tumors established as subcutaneous xenografts. Similar results were obtained with intra-tibial xenografts modeling metastasis to bones, the predominant site of metastasis for prostate cancer. In treatment studies, iRGD-liposomes markedly improved the AR-ASO efficacy in suppressing the growth of both subcutaneous xenografts and intra-tibial xenografts. The inhibitory effect on tumor growth was also significantly prolonged by the delivery of the AR-ASO in the iRGD-liposomes. Meanwhile, iRGD-liposomes did not increase ASO accumulation or toxicity in healthy organs. Overall, we provide here a delivery system that can significantly increase ASO accumulation and efficacy in solid tumors. These benefits are achieved without significant side effects, providing a way to increase the antitumor efficacy of ASOs.
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http://dx.doi.org/10.1002/adfm.202100478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8240484PMC
June 2021

Identification of novel genomic regions associated with nine mineral elements in Chinese winter wheat grain.

BMC Plant Biol 2021 Jul 1;21(1):311. Epub 2021 Jul 1.

State Key Laboratory of Crop Biology, Key Laboratory of Crop Biology of Shandong Province, Group of Wheat Quality and Molecular Breeding, College of Agronomy, Shandong Agricultural University, Tai'an, Shandong, 271000, P.R. China.

Background: Mineral elements are important for maintaining good human health besides heavy metals. Mining genes that control mineral elements are paramount for improving their accumulation in the wheat grain. Although previous studies have reported some loci for beneficial trace elements, they have mainly focused on Zn and Fe content. However, little information is available regarding the genetic loci differences in dissecting synchronous accumulation of multiple mineral elements in wheat grains, including beneficial and heavy elements. Therefore, a genome-wide association study (GWAS) was conducted on 205 wheat accessions with 24,355 single nucleotide polymorphisms (SNPs) to identify important loci and candidate genes for controlling Ca, Fe, Zn, Se, Cu, Mn, Cd, As, and Pb accumulation in wheat grains.

Results: A total of 101 marker-trait associations (MTAs) (P < 10) loci affecting the content of nine mineral elements was identified on chromosomes 1B, 1D, 2A, 2B, 3A, 3B, 3D, 4A, 4B, 5A, 5B, 5D, 6B, 7A, 7B, and 7D. Among these, 17 major MTAs loci for the nine mineral elements were located, and four MTAs loci (P < 10) were found on chromosomes 1B, 6B, 7B, and 7D. Eight multi-effect MTAs loci were detected that are responsible for the control of more than one trait, mainly distributed on chromosomes 3B, 7B, and 5A. Furthermore, sixteen candidate genes controlling Ca, Fe, Zn, Se, Cd, and Pb were predicted, whose functions were primarily related to ion binding, including metals, Fe, Ca, Cu, Mg, and Zn, ATP binding, ATPase activity, DNA binding, RNA binding, and protein kinase activity.

Conclusions: Our study indicated the existence of gene interactions among mineral elements based on multi-effect MTAs loci and candidate genes. Meanwhile this study provided new insights into the genetic control of mineral element concentrations, and the important loci and genes identified may contribute to the rapid development of beneficial mineral elements and a reduced content of harmful heavy metals in wheat grain.
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http://dx.doi.org/10.1186/s12870-021-03105-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252321PMC
July 2021

Chinese breast cancer patients with CYP2D6*10 mutant genotypes have a better prognosis with toremifene than with tamoxifen.

Asia Pac J Clin Oncol 2021 Jun 30. Epub 2021 Jun 30.

Department of Breast Radiation Oncology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, Liaoning Province, P. R. China.

Purpose: To evaluate the prognosis of estrogen receptor-positive breast cancer patients with CYP2D6*10 mutant genotypes under tamoxifen or toremifen therapy.

Methods: Estrogen receptor-positive breast cancer patients were selected and CYP2D6*10 genotypes (C/C, C/T, and T/T) were determined by Sanger sequencing. Patients were divided into tamoxifen, toremifene, or tamoxifen + toremifene groups according to prior therapy. The correlation between CYP2D6*10 genotype and disease-free survival was analyzed.

Results: In total, 293 estrogen receptor-positive breast cancer patients treated with tamoxifen or toremifene between 2008 and 2017 were studied. Median follow-up was 39 months (10-141). Of these, 107 (36.52%), 112 (38.23%), and 74 (25.26%) patients had C/C, C/T, and T/T genotypes, respectively. Genotype was significantly associated with disease-free survival in tamoxifen patients. Patients with C/T and T/T genotypes showed worse disease-free survival than patients with a C/C genotype. Genotype and disease-free survival in toremifene and tamoxifen+toremifene patients were not correlated. Of patients with a C/T genotype, toremifene or tamoxifen+toremifene groups showed better disease-free survival than tamoxifen patients. Although disease-free survival of patients with a T/T genotype in the three groups was not statistically different, tamoxifen patients showed worse disease-free survival. There was no correlation between different treatments and disease-free survival in patients with a C/C genotype. Cox proportional hazard analysis revealed toremifene patients had a better prognosis than tamoxifen patients; toremifene was an independent protective factoremifene for disease-free survival.

Conclusions: Tamoxifen was less effective in patients with CYP2D6*10 C/T and T/T genotypes. Estrogen receptor-positive breast cancer patients with a CYP2D6*10 mutation genotype have a better prognosis with toremifen than tamoxifen.
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http://dx.doi.org/10.1111/ajco.13571DOI Listing
June 2021

Evaluating the impacts of burning biomass on PM regional transport under various emission conditions.

Sci Total Environ 2021 Nov 19;793:148481. Epub 2021 Jun 19.

State Key Laboratory of Remote Sensing Science, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing 100094, China; University of the Chinese Academy of Sciences, Beijing 100049, China.

The fine particulate matter (PM) emitted by burning biomass has become the main source of pollution in cities; this pollution seriously threatens the ecosystem and inhabitants' health. A major challenge in dealing with this issue is the uncertainty regarding the influence of burning biomass on PM regional transport. In this study, Harbin-Changchun Megalopolis is the research area. Using the Hybrid Single-Particle Lagrangian Integrated Trajectory (HYSPLIT) model combined with satellite data and PM monitoring data, we quantitatively analyzed the regional transport of PM from burning biomass upwind of each city under different emission conditions. Conditions at burn sites, especially emission intensity and meteorological factors, as well as transport distance play significant roles in the regional transport of PM. Higher emission intensity aggravated the concentration of downwind PM, at most 19.7 μg ⋅ m. Shorter transport distance strengthened the impact of biomass burning on downstream PM by weakening elimination, which could be up to 96.8 μg ⋅ m. Moreover, meteorological factors at fire points were closely related to the transport of PM. First, lower planetary boundary layer height could enhance the transport of PM from the burning biomass by inhibiting vertical diffusion, and the enhancement could be up to 46.1 μg ⋅ m. Second, compared to strong wind, light wind caused the weaker dilution, enhancing PM regional transport by as much as 32.5 μg ⋅ m. Third, relatively humidity at 30%-40% had the strongest effect in facilitating the transport of PM from burning biomass. We conclude that comprehensively considering these three factors, namely the emission intensity, transport distance and meteorological factors at burn sites can facilitate the cross-regional development of accurate prediction models and effective pollution control measures.
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http://dx.doi.org/10.1016/j.scitotenv.2021.148481DOI Listing
November 2021

Nitrogen and Fluorine Dual Doping of Soft Carbon Nanofibers as Advanced Anode for Potassium Ion Batteries.

Small 2021 Jun 21:e2101576. Epub 2021 Jun 21.

Institute of Applied Physics and Materials Engineering, University of Macau, Avenida da Universidade, Taipa, Macau SAR, 999078, China.

Potassium-ion batteries (PIBs) are recognized as promising alternatives for lithium-ion batteries as the next-generation energy storage systems. However, the larger radius of K hinders the K insertion into the conventional carbon electrode and results in sluggish potassiation kinetics and poor cycling stability. Here, nitrogen and fluorine dual doping of soft carbon nanotubes (NFSC) anode are synthesized in one pot, achieving extraordinary electrochemical performance for PIBs. It is demonstrated that NFSC with a doping dose of 5.6 at% nitrogen and 1.3 at% fluorine together exhibits the highest reversible capacity of 238 mAh g at 0.2 A g and cycling stability of 186 mAh g after 1000 cycles at 1 A g . The extraordinary electrochemical performance can be attributed to the hollow structure, expanded interlayer distance, nitrogen and fluorine dual doping, and the binding ability of abundant defect sites. Moreover, density functional theory shows that the extra fluorine modification can dramatically enhance the conventional nitrogen doping effect and reduces the formation energy which makes a great contribution to the improvement of electrical conduction and K-ions insert. This work may promote the development of low-cost and sustainable carbon-based materials for PIBs and other advanced energy storage devices.
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http://dx.doi.org/10.1002/smll.202101576DOI Listing
June 2021

ALK7 Inhibition Protects Osteoblast Cells Against High Glucose-induced ROS Production via Nrf2/HO-1 Signaling Pathway.

Curr Mol Med 2021 Jun 14. Epub 2021 Jun 14.

Department of Endocrinology, The Second Medical Center & National Clinical Research Center, Chinese PLA General Hospital, Haidian District, Beijing, 100853, China.

Background: Some studies demonstrated that under high-glucose (HG) condition, osteoblasts develop oxidative stress, which will impair their normal functions. The effects of activin receptor-like kinase 7 (ALK7) silencing on HG-induced osteoblasts remained unclear.

Objective: The aim of this study was to explore the effect of ALK7 on HG-induced osteoblasts.

Methods: MC3T3-E1 cells were treated with different concentrations of HG (0, 50, 100, 200 and 300mg/dL), and the cell viability was detected using cell counting kit-8 (CCK-8). HG-treated MC3T3-E1 cells were transfected with siALK7 or ALK7 overexpression plasmid or siNrf2, and then the viability and apoptosis were detected by CCK-8 and flow cytometry. The levels of reactive oxygen species (ROS), collagen I and calcification nodule were determined by oxidative stress kits, Enzyme-linked immunosorbent assay and Alizarin red staining. The expressions of NF-E2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1) and osteoblast-associated genes were determined by quantitative real-time PCR (qRT-PCR) and Western blot.

Results: Cell viability was reduced with HG treatment. Silencing ALK7 inhibited the effect of HG on increasing cell apoptosis and ROS production, reduced cell viability, mineralized nodules, and downregulated collagen I and osteoblast-associated genes expression in MC3T3-E1 cells. ALK7 silencing activated the Nrf2/HO-1 signaling pathway by affecting expressions of HO-1 and Nrf2. ALK7 overexpression had the opposite effects. In addition, siNrf2 partially reversed the effects of ALK7 silencing on HG-induced MC3T3-E1 cells.

Conclusion: ALK7 silencing protected osteoblasts under HG condition possibly through activating the Nrf2/HO-1 pathway.
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http://dx.doi.org/10.2174/1566524021666210614144337DOI Listing
June 2021

Novel peripheral blood cell ratios: Effective 3-month post-mechanical thrombectomy prognostic biomarkers for acute ischemic stroke patients.

J Clin Neurosci 2021 Jul 5;89:56-64. Epub 2021 May 5.

Department of Clinical Medicine, Yangzhou University, Yangzhou 225001, China. Electronic address:

Background: Red blood cell distribution width to platelet ratio (RPR), Monocyte to high-density lipoprotein ratio (MHR), and Neutrophil to lymphocyte ratio (NLR) are novel inflammatory biomarkers in laboratory tests, which are associated with clinical outcomes in malignancy, cardiovascular and cerebrovascular diseases. This study aimed to determine their predictive value for the prognosis of acute ischemic stroke after mechanical thrombectomy (MT).

Methods: A total of 286 patients with acute ischemic stroke (AIS) admitted to a tertiary stroke center in China between January 2018 and February 2020 were treated by MT. Demographic characteristics, risk factors, clinical data, laboratory parameters, and clinical outcomes were recorded. The clinical outcome was disability or death at discharge or 90 days (defined as a modified Rankin Scale score of 3-6). The relationship between RPR, MHR, and NLR and functional outcomes was investigated by binary Logistic regression analysis, and further assessed by receiver operating characteristic curve (ROC). The Kaplan-Meier method was used to analyze the survival rate of prognosis factors.

Results: A total of 286 patients with AIS underwent MT (median age, 70.00; Interquartile range [IQR], 63.00-77.00; 41.6% female). Patients with unfavorable outcome showed higher RPR, MHR, and NLR than those with favorable outcome (RPR, [8.63; IQR, 6.30-10.78] vs [6.17; IQR, 5.11-7.35], P < 0.001; MHR, [0.40; IQR, 0.31-0.53] vs [0.34; IQR, 0.27-0.47], P = 0.005; NLR, [5.28; IQR, 3.63-8.02] vs [3.44; IQR, 2.63-4.63], P < 0.001). In multivariate and ROC curve analysis, higher RPR (>8.565) (odds ratio [OR], 1.671; 95% confidence interval [CI], 1.127-2.479; P = 0.011) and higher MHR (>0.368) (OR, 9.374; 95% CI, 1.160-75.767; P = 0.036), higher NLR (>4.030) (OR, 1.957; 95% CI, 1.382-2.770; P < 0.001) were independently associated with unfavorable outcome. The combined predictive value of the three indexes was higher than that of a single index. Kaplan-Meier survival curve analysis showed that the 90-day survival rate (82.1% vs 66.2%) was significantly different between the low RPR group and the high RPR group (χ = 4.960, P = 0.026).

Conclusion: Higher RPR, MHR, and NLR might be independent risk factors for predicting 3-month poor prognosis in patients with AIS who underwent MT.
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http://dx.doi.org/10.1016/j.jocn.2021.04.013DOI Listing
July 2021

Distribution of Peripheral Blood Cells in Esophageal Cancer Patients During Concurrent Chemoradiotherapy Predicts Long-Term Locoregional Progression Hazard After Treatment (GASTO1072).

Cancer Manag Res 2021 25;13:4203-4215. Epub 2021 May 25.

Department of Radiation Oncology, Cancer Hospital of Shantou University Medical College, Shantou, 515031, People's Republic of China.

Purpose: Predicting the response to chemoradiotherapy is critical for the optimal management of esophageal cancer; however, it remains an unmet clinical need. This study aimed to evaluate the predictive potential of peri-treatment peripheral blood cells (PBC) in disease progression hazard in esophageal cancer following chemoradiotherapy.

Patients And Methods: A total of 87 patients with primary esophageal squamous cell carcinoma were subjected to definitive concurrent chemoradiotherapy in a Phase II trial. PBC parameters (hemoglobin, neutrophils, platelets, lymphocytes, and monocytes) were collected at seven time points throughout the course of radiotherapy. The potential of peri-treatment PBC parameters to predict the 3-year cumulative hazard of tumor progression was evaluated.

Results: Patients with disease progression displayed distinct distribution patterns of peri-treatment PBC compared to that in patients without disease progression. Greater prediction capabilities for risk of locoregional disease progression were found in PBC collected after the start of radiotherapy compared to those in their pretreatment counterparts, and in individual parameters rather than cell-to-cell ratios. The most predictive PBC parameters were integrated by summation and designated as a PBC score (PBCS), which further augmented their predictive power. Patients classified according to their PBCS (high vs medium v. low) had significantly different 3-year cumulative hazards of locoregional progression (58% vs 29% vs 7%, P = 0.0017). Multivariate analysis confirmed that high PBCS (HR, 12.2; 95% CI, 2.0-76.3; P = 0.007) and medium (HR, 5.8; 95% CI 1.2-27.7; P = 0.028) were independent indicators of locoregional progression.

Conclusion: Systematic analysis of PBC distribution in esophageal cancer patients undergoing definitive chemoradiotherapy could help predict long-term locoregional progression hazard after treatment.
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http://dx.doi.org/10.2147/CMAR.S307695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164679PMC
May 2021

Effects of Nogo-A and its receptor on the repair of sciatic nerve injury in rats.

Braz J Med Biol Res 2021 31;54(9):e10842. Epub 2021 May 31.

Department of Hand Surgery, Yantaishan Hospital, Yantai, China.

Regeneration of injured peripheral nerves is an extremely complex process. Nogo-A (neurite outgrowth inhibitor-A) inhibits axonal regeneration by interacting with Nogo receptor in the myelin sheath of the central nervous system (CNS). The aim of this study was to investigate the effects of Nogo-A and its receptor on the repair of sciatic nerve injury in rats. Sprague-Dawley rats (n=96) were randomly divided into 4 groups: control group (control), sciatic nerve transection group (model), immediate repair group (immediate repair), and delayed repair group (delayed repair). The rats were euthanized 1 week and 6 weeks after operation. The injured end tissues of the spinal cord and sciatic nerve were obtained. The protein expressions of Nogo-A and Nogo-66 receptor (NgR) were detected by immunohistochemistry. The protein expressions of Nogo-A, NgR, and Ras homolog family member A (RhoA) were detected by western blot. At 1 week after operation, the pathological changes in the immediate repaired group were less, and the protein expressions of Nogo-A, NgR, and RhoA in the spinal cord and sciatic nerve tissues were decreased (P<0.05) compared with the model group. After 6 weeks, the pathological changes in the immediate repair group and the delayed repair group were alleviated and the protein expressions decreased (P<0.05). The situation of the immediate repair group was better than that of the delayed repair group. Our data suggest that the expression of Nogo-A and its receptor increased after sciatic nerve injury, indicating that Nogo-A and its receptor play an inhibitory role in the repair process of sciatic nerve injury in rats.
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http://dx.doi.org/10.1590/1414-431X2020e10842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8186374PMC
June 2021

rs1344706 polymorphism of zinc finger protein 804a (ZNF804a) gene related to the integrity of white matter fiber bundle in schizophrenics.

Exp Ther Med 2021 Jul 18;22(1):778. Epub 2021 May 18.

Department of Psychiatry, Qiqihar Medical University, Qiqihar, Heilongjiang 161000, P.R. China.

Genetic factors play an important role in the pathogenesis of schizophrenia (SZ), and the zinc finger protein 804a (ZNF804a) gene has been considered to be a risk gene for schizophrenia. In the present study, the correlation between rs1344706 polymorphism of ZNF804a gene and the integrity of white matter in schizophrenic cases was explored. A total of 60 SZ patients and 100 healthy controls (HC) were included to undergo head MRI. According to the genotyping of rs1344706 in ZNF804a, the subjects in each group were divided into a normal allele and risk allele-carrying group. The imaging data were preprocessed by PANDA software, and thefractional anisotropy (FA) of each subject was calculated. With SPM8 software, age and years of education were considered as covariates, and diagnosis as well as genotype (AA, GG/AG) were considered as intergroup factors. Four groups of FA images were analyzed by two-factor analysis of variance. The FA value of the right posterior radiocrown in the patient group was lower than that in the control group, and the difference was statistically significant. The FA value of the right lower frontal occipital tract and the right upper radiocrown in the G allele carrier group was lower than that in the A allele homozygous group. There was detection of an interaction between the FA value of the splenium of corpus callosum, the body part of the corpus callosum and the right cingulate tract. In the present study, it was demonstrated that the rs1344706 GG/AG genotype of the ZNF804a gene locus in SZ patients suffered from abnormal structure in a specific region of the brain. This finding indicated that the rs1344706 single nucleotide polymorphism of the ZNF804a gene may affect the integrity of the white matter of the brain in SZ patients and may be involved in the pathophysiological mechanism of SZ.
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http://dx.doi.org/10.3892/etm.2021.10210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8145689PMC
July 2021

Development and external validation of a breast cancer absolute risk prediction model in Chinese population.

Breast Cancer Res 2021 05 29;23(1):62. Epub 2021 May 29.

Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, 38 Xueyuan Road, Beijing, 100191, China.

Backgrounds: In contrast to developed countries, breast cancer in China is characterized by a rapidly escalating incidence rate in the past two decades, lower survival rate, and vast geographic variation. However, there is no validated risk prediction model in China to aid early detection yet.

Methods: A large nationwide prospective cohort, China Kadoorie Biobank (CKB), was used to evaluate relative and attributable risks of invasive breast cancer. A total of 300,824 women free of any prior cancer were recruited during 2004-2008 and followed up to Dec 31, 2016. Cox models were used to identify breast cancer risk factors and build a relative risk model. Absolute risks were calculated by incorporating national age- and residence-specific breast cancer incidence and non-breast cancer mortality rates. We used an independent large prospective cohort, Shanghai Women's Health Study (SWHS), with 73,203 women to externally validate the calibration and discriminating accuracy.

Results: During a median of 10.2 years of follow-up in the CKB, 2287 cases were observed. The final model included age, residence area, education, BMI, height, family history of overall cancer, parity, and age at menarche. The model was well-calibrated in both the CKB and the SWHS, yielding expected/observed (E/O) ratios of 1.01 (95% confidence interval (CI), 0.94-1.09) and 0.94 (95% CI, 0.89-0.99), respectively. After eliminating the effect of age and residence, the model maintained moderate but comparable discriminating accuracy compared with those of some previous externally validated models. The adjusted areas under the receiver operating curve (AUC) were 0.634 (95% CI, 0.608-0.661) and 0.585 (95% CI, 0.564-0.605) in the CKB and the SWHS, respectively.

Conclusions: Based only on non-laboratory predictors, our model has a good calibration and moderate discriminating capacity. The model may serve as a useful tool to raise individuals' awareness and aid risk-stratified screening and prevention strategies.
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http://dx.doi.org/10.1186/s13058-021-01439-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164768PMC
May 2021

Electron-Catalyzed Dehydrogenation in a Single-Molecule Junction.

J Am Chem Soc 2021 Jun 27;143(22):8476-8487. Epub 2021 May 27.

Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, United States.

Investigating how electrons propagate through a single molecule is one of the missions of molecular electronics. Electrons, however, are also efficient catalysts for conducting radical reactions, a property that is often overlooked by chemists. Special attention should be paid to electron catalysis when interpreting single-molecule conductance results for the simple reason that an unexpected reaction mediated or triggered by electrons might take place in the single-molecule junction. Here, we describe a counterintuitive structure-property relationship that molecules, both linear and cyclic, employing a saturated bipyridinium-ethane backbone, display a similar conductance signature when compared to junctions formed with molecules containing conjugated bipyridinium-ethene backbones. We describe an ethane-to-ethene transformation, which proceeds in the single-molecule junction by an electron-catalyzed dehydrogenation. Electrochemically based ensemble experiments and theoretical calculations have revealed that the electrons trigger the redox process, and the electric field promotes the dehydrogenation. This finding not only demonstrates the importance of electron catalysis when interpreting experimental results, but also charts a pathway to gaining more insight into the mechanism of electrocatalytic hydrogen production at the single-molecule level.
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http://dx.doi.org/10.1021/jacs.1c03141DOI Listing
June 2021

Preoperative Serum Gamma-Glutamyltransferase as a Prognostic Biomarker in Patients Undergoing Radical Cystectomy for Bladder Cancer.

Front Oncol 2021 7;11:648904. Epub 2021 May 7.

Department of Urology, Shijiazhuang People's Hospital, Shijiazhuang, China.

Background: Serum gamma-glutamyltransferase (GGT) has been reported to be correlated with survival in a variety of malignancies. However, its effect on patients with bladder cancer (BC) treated by radical cystectomy has never been evaluated.

Patients And Methods: We retrospectively evaluated 263 patients who underwent radical surgery in our center. Baseline features, hematologic variables, and follow-up data were obtained. The endpoints included overall survival (OS), cancer-specific survival (CSS), and disease-free survival (DFS). The relationship between GGT and survival were evaluated.

Results: The median follow-up period for all patients was 34.7 (22.9-45.9) months. At the last follow-up, 67 patients died, 51 patients died of cancer, 92 patients experienced disease recurrence. Patients with an elevated serum GGT had a higher rate of pT3-T4 tumors. Patients with a higher preoperative serum GGT had a lower rate of OS, CSS and DFS (P < 0.001 for all). Multivariate analysis identified that preoperative serum GGT was independent predictor of OS (HR: 3.027, 95% CI: 1.716-5.338; P < 0.001), CSS (HR: 2.115, 95% CI: 1.093-4.090; P = 0.026), DFS (HR: 2.584, 95% CI: 1.569-4.255; P < 0.001). Age, diabetes history, pathologic T stage, and lymph node status also were independent predictors of prognosis for BC patients.

Conclusions: Our results indicated that preoperative serum GGT was an independent prognosis predictor for survival of BC patients after radical cystectomy, and can be included in the prognostic models.
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http://dx.doi.org/10.3389/fonc.2021.648904DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8138052PMC
May 2021

A novel lncRNA promotes myogenesis of bovine skeletal muscle satellite cells via PFN1-RhoA/Rac1.

J Cell Mol Med 2021 May 4. Epub 2021 May 4.

Tianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry, College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin, China.

Myogenesis, the process of skeletal muscle formation, is a highly coordinated multistep biological process. Accumulating evidence suggests that long non-coding RNAs (lncRNAs) are emerging as a gatekeeper in myogenesis. Up to now, most studies on muscle development-related lncRNAs are mainly focussed on humans and mice. In this study, a novel muscle highly expressed lncRNA, named lnc23, localized in nucleus, was found differentially expressed in different stages of embryonic development and myogenic differentiation. The knockdown and over-expression experiments showed that lnc23 positively regulated the myogenic differentiation of bovine skeletal muscle satellite cells. Then, TMT 10-plex labelling quantitative proteomics was performed to screen the potentially regulatory proteins of lnc23. Results indicated that lnc23 was involved in the key processes of myogenic differentiation such as cell fusion, further demonstrated that down-regulation of lnc23 may inhibit myogenic differentiation by reducing signal transduction and cell fusion among cells. Furthermore, RNA pulldown/LC-MS and RIP experiment illustrated that PFN1 was a binding protein of lnc23. Further, we also found that lnc23 positively regulated the protein expression of RhoA and Rac1, and PFN1 may negatively regulate myogenic differentiation and the expression of its interacting proteins RhoA and Rac1. Hence, we support that lnc23 may reduce the inhibiting effect of PFN1 on RhoA and Rac1 by binding to PFN1, thereby promoting myogenic differentiation. In short, the novel identified lnc23 promotes myogenesis of bovine skeletal muscle satellite cells via PFN1-RhoA/Rac1.
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http://dx.doi.org/10.1111/jcmm.16427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8256363PMC
May 2021

Ibandronate sodium and zoledronate sodium in the treatment of senile osteoporosis: efficacy, impact on quality of life and cost-effectiveness analysis.

Am J Transl Res 2021 15;13(3):1764-1771. Epub 2021 Mar 15.

Department of Pharmacy, The Third Hospital of Hebei Medical University Shijiazhuang, Hebei Province, China.

Objective: To investigate the efficacy of ibandronate sodium and zoledronate sodium in the treatment of senile osteoporosis and their impact on quality of life, and to analyze the cost-effectiveness.

Methods: A retrospective study was conducted on 215 patients with senile osteoporosis, who were admitted to our hospital from January 2017 to June 2019. Among them, 115 cases treated with ibandronate sodium were set to group A and 100 cases treated with zoledronate sodium were set to group B. The clinical efficacy, bone mineral density (BMD) before and after treatment, bone metabolic markers (alkaline phosphatase (ALP), blood phosphorus (P), blood calcium ion (Ca)), quality of life, adverse reactions, cost-effectiveness indicators (length of hospitalization, cost) and complications were compared between the two groups.

Results: Total therapeutic response rate in group A was 96.52% (111/115), which was not statistically different from that of 93.00% (93/100) in group B (P=0.242). After treatment, the BMD, ALP, BGP and Ca levels of the lumbar spine L1-L4, left femoral neck and right femoral neck, as well as quality of life scores in the two groups increased (P < 0.05), while serum ALP levels decreased (P < 0.05), however, there was no statistically significant difference between the two groups (P > 0.05). The incidence of adverse reactions in group A was 3.48% (4/115), which showed no statistical significance with that of 5.00% (5/100) in group B (P=0.830). The length of hospitalization, annual treatment expense, medical insurance expense and out-of-pocket payments in group A were all lower than those in group B (P < 0.05).

Conclusion: In the treatment of senile osteoporosis, the efficacy and adverse reactions of ibandronate sodium and zoledronate sodium are similar, both of them can effectively improve the quality of life. However, the cost-effectiveness of ibandronate sodium is better than that of zoledronate sodium.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8014411PMC
March 2021

Phase Tailoring of Ruddlesden-Popper Perovskite at Fixed Large Spacer Cation Ratio.

Small 2021 Apr 4:e2100560. Epub 2021 Apr 4.

Joint Key Laboratory of the Ministry of Education, Institute of Applied Physics and Materials Engineering, University of Macau, Avenida da Universidade, Taipa, Macao, 999078, China.

Ruddlesden-Popper (RP) metal halide perovskites are considered as promising optoelectronic materials due to their good environmental stability and desirable optoelectronic properties. However, the phase composition and ordering in the deposited film, with a fixed ratio of large organic spacer cation in the precursor solution, are hard to be further tailored for specific optoelectronic applications. Herein, it is shown that even with a fixed spacer cation ratio, the phase composition and ordering can still be largely regulated by utilizing different crystallization kinetics of various cations with the inorganic octahedral lead halide. By using two different short cations to compete with the large spacer cation, the phase composition can be continuously tailored from thin multiple quantum wells (MQWs) dominated to 3D perovskite dominated. The phase ordering can be reversed from small n phases' prior to large n phases' prior near the substrate. Finally, with the same amount of large spacer cation protection, the perovskite can be tailored for both high-performance electroluminescence and photovoltaics with favorable energetic landscape for the corresponding desired first-order excitonic recombination and second-order free electron-hole recombination, respectively. This exploration substantially contributes to the understanding of precise phase engineering in RP perovskite and may provide a new insight into the design of multiple functional devices.
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http://dx.doi.org/10.1002/smll.202100560DOI Listing
April 2021

Corrigendum to "Long noncoding RNA LINC00657 inhibits cervical cancer development by sponging miR-20a-5p and targeting RUNX3" [Canc. Lett. 498 (2021) 130-141].

Cancer Lett 2021 Jun 30;508:73-75. Epub 2021 Mar 30.

Department of Obstetrics and Gynecology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, China. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2021.03.005DOI Listing
June 2021

Bayberry tannin directed assembly of a bifunctional graphene aerogel for simultaneous solar steam generation and marine uranium extraction.

Nanoscale 2021 Mar;13(10):5419-5428

Suzhou Institute of Nano-tech and Nano-bionics, Chinese Academy of Sciences, Suzhou, 215123, P.R. China. and Division of Surgery & Interventional Science, University College London, London NW3 2PF, UK.

Solar steam generation and marine uranium extraction are promising methods for obtaining sufficient fresh water and nuclear fuel from the ocean, respectively, for overcoming water and energy crises. In this work, a bayberry tannin (BT) directed assembly of a bifunctional graphene aerogel (GA) has been designed for simultaneous solar steam generation (1.80 kg m-2 h-1 with a high solar efficiency of 95.5%) and marine uranium extraction (230.10 mg g-1 within 6 h). BT molecules are uniformly decorated inside the typical porous channels of GA, which integrates the excellent uranium binding of BT and the efficient light-to-heat conversion of GA. It is found that the hydrophilic nature of BT can improve fluid infiltration in the GA matrix for solar steam generation while the steam generation induced transpiration can accelerate the adsorption of uranium ions for marine uranium extraction. The unique bifunctional ability of the BT-GA composite paves a new way to utilize the abundant resources in the ocean.
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http://dx.doi.org/10.1039/d0nr08956gDOI Listing
March 2021

A New Recognition Method for the Auditory Evoked Magnetic Fields.

Comput Intell Neurosci 2021 9;2021:6645270. Epub 2021 Feb 9.

State Key Laboratory of Advanced Optical Communication Systems and Networks, Department of Electronics and Centre for Quantum Information Technology, Peking University, Beijing 100871, China.

Magnetoencephalography (MEG) is a persuasive tool to study the human brain in physiology and psychology. It can be employed to obtain the inference of change between the external environment and the internal psychology, which requires us to recognize different single trial event-related magnetic fields (ERFs) originated from different functional areas of the brain. Current recognition methods for the single trial data are mainly used for event-related potentials (ERPs) in the electroencephalography (EEG). Although the MEG shares the same signal sources with the EEG, much less interference from the other brain tissues may give the MEG an edge in recognition of the ERFs. In this work, we propose a new recognition method for the single trial auditory evoked magnetic fields (AEFs) through enhancing the signal. We find that the signal strength of the single trial AEFs is concentrated in the primary auditory cortex of the temporal lobe, which can be clearly displayed in the 2D images. These 2D images are then recognized by an artificial neural network (ANN) with 100% accuracy, which realizes the automatic recognition for the single trial AEFs. The method not only may be combined with the source estimation algorithm to improve its accuracy but also paves the way for the implementation of the brain-computer interface (BCI) with the MEG.
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http://dx.doi.org/10.1155/2021/6645270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7892250PMC
July 2021

Empowerment in Chinese primary caregivers of post-stroke patients with disability: A cross-sectional study.

Authors:
Youhua Liu Hong Guo

Medicine (Baltimore) 2021 Feb;100(5):e23774

School of Nursing, Beijing University of Traditional Chinese Medicine, Beijing.

Abstract: To investigate the status quo of empowerment ability of primary caregivers in post-stroke patients with disability and its influencing factors.A cross-sectional design and a convenience sample were used. Participants (N = 189) from 3 hospital in Beijing were recruited from October 2018 to June 2019. The following measurement tools were used in this study: Barthel index, Main Caregiver Empowerment Measurement, General Self-Efficacy Scale, Simplified Coping Style Questionnaire and Social Support Rating Scale. Multiple linear stepwise regression analysis was used to statistically infer the influencing factors of empowerment ability of primary caregivers.The total score of main caregivers' empowerment measurement among the participants was 161.03 ± 14.678, the median (interquartile range) score was 162.00 (150.00-171.50). The average scores of each dimension ranged from high to low: relationship with the person being cared for, goodwill care, expectation for care outcomes, subjectivity of caregiver, faith in care, understanding of care role, knowledge and skills of care, scruples about the surroundings, personal resources. The single factor analysis showed that the patient's payment method for medical expenses, whether the patient accompanied by other chronic diseases and the gender of the caregiver had an effect on the empowerment ability of primary caregivers, and the positive coping style, negative coping style, self-efficacy and subjective support of primary caregivers were positively correlated with their empowerment ability (P < .05). Multiple linear stepwise regression analysis showed that the type of payment for treatment of patients (b = 7.449, P < .01), and gender of caregivers (b = 5.039, P < .05), subjective support of caregivers (b = 0.439, P < .05), positive coping style of caregivers (b = 0.585, P < .01), self-efficacy of caregivers (b = 6.456, P < .01) were the main influencing factors of empowerment ability of primary caregivers.The empowerment ability of the primary caregivers of post-stroke patients with disability in China is at the upper middle level. However, there are more scruples about the surrounding and less personal resources, which deserve attention. Furthermore, the identification of the factors related to empowerment lays a foundation for clinical nursing practitioners to further develop targeted interventions on empowerment of caregivers.
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http://dx.doi.org/10.1097/MD.0000000000023774DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870185PMC
February 2021
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