Publications by authors named "Hong Fu"

184 Publications

Structural insights into sphingosine-1-phosphate recognition and ligand selectivity of S1PR3-Gi signaling complexes.

Cell Res 2021 Sep 20. Epub 2021 Sep 20.

Division of Nephrology and Kidney Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

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http://dx.doi.org/10.1038/s41422-021-00567-wDOI Listing
September 2021

Dosimetric Comparison, Treatment Efficiency Estimation, and Biological Evaluation of Popular Stereotactic Radiosurgery Options in Treating Single Small Brain Metastasis.

Front Oncol 2021 5;11:716152. Epub 2021 Aug 5.

Department of Radiation Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.

Objectives: This study aimed to show the advantages of each stereotactic radiosurgery (SRS) treatment option for single small brain metastasis among Gamma Knife (GK), Cone-based VMAT (Cone-VMAT), and MLC-based CRT (MLC-CRT) plans.

Materials And Methods: GK, Cone-VMAT, and MLC-CRT SRS plans were retrospectively generated for 11 patients with single small brain metastasis whose volume of gross tumor volume (GTV) ranged from 0.18 to 0.76 cc (median volume 0.60 cc). Dosimetric parameters, treatment efficiency, and biological parameters of the three techniques were compared and evaluated. The metric variation with the planning target volume (PTV) was also studied.

Results: The conformity index (CI) was similar in GK and MLC-CRT plans, higher than Cone-VMAT. Cone-VMAT achieved comparable volume covered by 12 Gy (V12) and gradient index (GI) as GK, lower than MLC-CRT. The heterogeneity index (HI) of GK, Cone-VMAT, and MLC-CRT decreased sequentially. GK gave the lowest volume covered by 3 Gy (V3) and 6 Gy (V6), while MLC-CRT got the highest. The beam-on time and treatment time of GK, Cone-VMAT, and MLC-CRT decreased in turn. Tumor control probability (TCP) of all three SRS plans was greater than 98%, and normal tissue complication probability (NTCP) of all organs at risk (OARs) was below 0.01%. GK and Cone-VMAT resulted in superior TCP and NTCP of the normal brain tissue than MLC-CRT. The relative value of Cone-VMAT and GK for all metrics hardly changed with the target volume. Except for the unchanged HI and TCP, the other results of MLC-CRT with respect to GK improved as the target volume increased. MLC-CRT could produce higher CI than GK and Cone-VMAT when the target volume increased above 2 and 1.44 cc, respectively.

Conclusion: For single small brain metastases, Cone-VMAT may be used as an alternative to GK-free centers. In addition to the advantage of short treatment time, MLC-CRT showed superiority in CI as the target volume increased. Treatment centers can choose appropriate SRS technique on a case-by-case basis according to institutional conditions and patients' individual needs.
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http://dx.doi.org/10.3389/fonc.2021.716152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8447903PMC
August 2021

Expression of oncogenic long noncoding RNA PSMG3-antisense 1 in lung squamous cell carcinoma.

Oncol Lett 2021 Nov 27;22(5):751. Epub 2021 Aug 27.

Department of Interventional Oncology, The Fourth People's Hospital of Shenyang, Shenyang, Liaoning 110031, P.R. China.

Lung squamous cell carcinoma (LUSC) is one of the most common subtypes of lung cancer that accounts for ~50% of all lung cancer cases. Long noncoding RNA (lncRNA) PSMG3-antisense (AS) 1 has been suggested to play an important role in various types of cancer. Therefore, the aim of the present study was to investigate the role of PSMG3-AS1 using clinical specimens and data from 130 patients with LUSC. The expression levels of PSMG3-AS1 and miR-143-3p were detected in LUSC specimens, and the correlation between lncRNA PSMG3-AS1 expression and patient clinical characteristics was analyzed. Cell Counting Kit-8, Transwell migration and invasion assays were used to investigate the functional role of PSMG3-AS1 in LUSC. The mechanism of PSMG3-AS1 on LUSC cells was also investigated using a luciferase activity assay with wild-type or mutated PSMG3-AS1. PSMG3-AS1 was found to be upregulated in LUSC, and high expression was associated with positive lymph node metastasis and a higher TNM stage. The results of multivariate Cox regression analysis revealed that PSMG3-AS1 may serve as an independent prognostic indicator in LUSC. Furthermore, inhibiting PSMG3-AS1 expression reduced tumor cell proliferative, migratory and invasive abilities. Moreover, PSMG3-AS1 was found to be closely associated with miR-143-3p in LUSC, and thus may become a potential prognostic marker and therapeutic target for the treatment of LUSC in the future.
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http://dx.doi.org/10.3892/ol.2021.13012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436406PMC
November 2021

Magnetic Control and Real-Time Monitoring of Stem Cell Differentiation by the Ligand Nanoassembly.

Small 2021 Oct 13;17(41):e2102892. Epub 2021 Sep 13.

Department of Materials Science and Engineering, Korea University, Seoul, 02841, Republic of Korea.

Native extracellular matrix (ECM) exhibits dynamic change in the ligand position. Herein, the ECM-emulating control and real-time monitoring of stem cell differentiation are demonstrated by ligand nanoassembly. The density of gold nanoassembly presenting cell-adhesive Arg-Gly-Asp (RGD) ligand on Fe O (magnetite) nanoparticle in nanostructures flexibly grafted to material is changed while keeping macroscale ligand density invariant. The ligand nanoassembly on the Fe O can be magnetically attracted to mediate rising and falling ligand movements via linker stretching and compression, respectively. High ligand nanoassembly density stimulates integrin ligation to activate the mechanosensing-assisted stem cell differentiation, which is monitored via in situ real-time electrochemical sensing. Magnetic control of rising and falling ligand movements hinders and promotes the adhesion-mediated mechanotransduction and differentiation of stem cells, respectively. These rising and falling ligand states yield the difference in the farthest distance (≈34.6 nm) of the RGD from material surface, thereby dynamically mimicking static long and short flexible linkers, which hinder and promote cell adhesion, respectively. Design of cytocompatible ligand nanoassemblies can be made with combinations of dimensions, shapes, and biomimetic ligands for remotely regulating stem cells for offering novel methodologies to advance regenerative therapies.
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http://dx.doi.org/10.1002/smll.202102892DOI Listing
October 2021

β-elemene inhibits non-small cell lung cancer cell migration and invasion by inactivating the FAK-Src pathway.

Exp Ther Med 2021 Oct 2;22(4):1095. Epub 2021 Aug 2.

Department of Radiology, The First Affiliated Hospital of USTC, Division of Life and Medicine, University of Science and Technology of China, Hefei, Anhui 230031, P.R. China.

Despite sustained effort, the prognosis of lung cancer remains poor and the therapeutic responses are limited. Cell movement ability is a prerequisite for lung cancer metastasis, which involves focal adhesion kinase (FAK)-mediated cell migration and invasion via complex formation with Src. Hence, FAK-Src signaling might be an effective target for anti-cancer treatment. β-elemene, the major component of elemene extracted from Curcuma Rhizoma, exhibits broad-spectrum anti-tumor properties. However, the role of β-elemene in lung cancer cell motility and its possible mechanism remain unknown. Herein, the role of β-elemene in the migration and invasion of two non-small cell lung cancer (NSCLC) cell lines was investigated by performing wound-healing and Transwell assays. The mRNA expression levels of genes associated with motility, including , , , matrix metalloprotease ()2 and , were examined by reverse transcription-quantitative polymerase chain reaction. To determine whether β-elemene acts through FAK-Src signaling, western blotting was performed and the levels of phosphorylated FAK and Src were detected. The results indicated that β-elemene inhibited the migration and invasion of A549 and NCI-H1299 (H1299) cells, while the motility-associated genes were de-regulated following exposure to β-elemene. Furthermore, β-elemene decreased the activity of FAK and Src. Overall, these results suggest that β-elemene potentially inhibits NSCLC through FAK-Src signaling.
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http://dx.doi.org/10.3892/etm.2021.10529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8383758PMC
October 2021

Mitigation of urbanization effects on aquatic ecosystems by synchronous ecological restoration.

Water Res 2021 Oct 21;204:117587. Epub 2021 Aug 21.

Donghu Experimental Station of Lake Ecosystems, State Key Laboratory of Freshwater Ecology and Biotechnology of China, Institute of Hydrobiology, Chinese Academy of Sciences, No.7 Donghu South Road, Wuhan 430072, PR China; State Key laboratory of Marine Resource Utilization in South China Sea, Hainan University, Haikou, PR China. Electronic address:

Ecosystem degradation and biodiversity loss have been caused by economic booms in developing countries over recent decades. In response, ecosystem restoration projects have been advanced in some countries but the effectiveness of different approaches and indicators at large spatio-temporal scales (i.e., whole catchments) remains poorly understood. This study assessed the effectiveness of a diverse array of 440 aquatic restoration projects including wastewater treatment, constructed wetlands, plant/algae salvage and dredging of contaminated sediments implemented and maintained from 2007 to 2017 across more than 2000 km of the northwest Taihu basin (Yixing, China). Synchronized investigations of water quality and invertebrate communities were conducted before and after restoration. Our analysis showed that even though there was rapid urbanization at this time, nutrient concentrations (NH-N, TN, TP) and biological indices of benthic invertebrate (taxonomic richness, Shannon diversity, sensitive taxon density) improved significantly across most of the study area. Improvements were associated with the type of restoration project, with projects targeting pollution-sources leading to the clearest ecosystem responses compared with those remediating pollution sinks. However, in some locations, the recovery of biotic communities appears to lag behind nutrients (e.g., nitrogen and phosphorus), likely reflecting long-distance re-colonization routes for invertebrates given the level of pre-restoration degradation of the catchment. Overall, the study suggests that ecological damage caused by recent rapid economic development in China could potentially be mitigated by massive restoration investments synchronized across whole catchments, although these effects could be expected to be enhanced if urbanization rates were reduced at the same time.
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http://dx.doi.org/10.1016/j.watres.2021.117587DOI Listing
October 2021

Application of intraoperative ultrasound in liver surgery.

Authors:
Ya-Wei Xu Hong Fu

Hepatobiliary Pancreat Dis Int 2021 Oct 10;20(5):501-502. Epub 2021 Aug 10.

Department of Hepatobiliary Surgery, Shaoxing People's Hospital, Shaoxing Hospital of Zhejiang University, Shaoxing 312000, China. Electronic address:

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http://dx.doi.org/10.1016/j.hbpd.2021.07.012DOI Listing
October 2021

Takotsubo syndrome after liver transplantation: An association with intraoperatively administered epinephrine and fentanyl.

Clin Transplant 2021 Aug 17:e14463. Epub 2021 Aug 17.

Department of Anesthesiology and Perioperative Medicine, Ronald Reagan UCLA Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.

Takotsubo syndrome (TTS) can develop after liver transplant (LT), but its predisposing factors are poorly understood. In this study, we aimed to determine if perioperative factors were associated with posttransplant TTS. Adult patients who underwent primary LT between 2006 and 2018 were included. Patients with and without TTS were identified and matched by propensity scores. Of 2181 LT patients, 38 developed postoperative TTS with a mean left ventricular ejection fraction of 25.5% (±7.8%). Multivariable logistic regression revealed two preoperative risk factors (alcoholic cirrhosis and model for end-stage liver disease-sodium scores) for TTS. Post-propensity match analyses showed that TTS patients had significantly higher doses of epinephrine and lower doses of fentanyl during LT compared with non-TTS patients. A higher dose of epinephrine and a lower dose of fentanyl was associated with a higher predicted probability of TTS. All TTS patients had full recovery of cardiac function and had comparable 1-year survival. In conclusion, TTS occurred at a rate of 1.7% after LT and was associated with two pretransplant risk factors. The higher doses of epinephrine and lower doses of fentanyl administered during LT were associated with posttransplant TTS. More studies on the relationship between intraoperative medications and TTS are warranted.
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http://dx.doi.org/10.1111/ctr.14463DOI Listing
August 2021

Weak fault detection with a two-stage key frequency focusing model.

ISA Trans 2021 Jun 15. Epub 2021 Jun 15.

Key Laboratory of Education Ministry for Modern Design & Rotor-Bearing System, Xi'an Jiaotong University, 28 Xianning West Road, Xi'an, China.

The fault diagnosis of early failure bearing can discover the potential danger in the mechanical equipment in time. It remains a great challenge due to the noise interference. Although many diagnosis methods have been proposed, the characteristics of signal have not yet been fully investigated, which leads to unsatisfactory diagnosis results. To solve this problem, a weak fault detection method with a two-stage key frequency focusing model is designed. Translation invariance in time domain and translation variance in frequency domain are systematically considered. The effectiveness is verified on four constructed datasets. The results show that the designed network has the best comprehensive performance comparing to the state-of-the-art methods.
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http://dx.doi.org/10.1016/j.isatra.2021.06.014DOI Listing
June 2021

Love Forgiveness and Subjective Well-Being in Chinese College Students: The Mediating Role of Interpersonal Relationships.

Front Psychol 2021 4;12:634910. Epub 2021 Jun 4.

School of Psychology, Nanjing Normal University, Nanjing, China.

Love forgiveness is categorized as forgiveness in a specific relationship, which is the tendency of individuals to forgive the objects of their interpersonal relationships. We investigated 831 undergraduate students in China with a love forgiveness questionnaire, a subjective well-being questionnaire and an interpersonal relationship comprehensive diagnostic, including demographic variables. Students of different genders and grades showed significant differences across the three questionnaires. There were significant correlations between love forgiveness, interpersonal relationships, and subjective well-being of Chinese college students. Interpersonal relationships played an intermediary role between love forgiveness and subjective well-being of Chinese college students. Specifically, whereas Chinese college students' love forgiveness could directly promote the improvement of subjective well-being, love forgiveness could also indirectly improve subjective well-being through interpersonal relationships. The mediating effect of interpersonal relationships between love forgiveness and subjective well-being accounted for 40.52% of the total effect. This provides a new way of thinking for psychological counselors to approach the intimate relationship problems of college students.
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http://dx.doi.org/10.3389/fpsyg.2021.634910DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8211753PMC
June 2021

Prenatal exposure to phthalates with preterm birth and gestational age: A systematic review and meta-analysis.

Chemosphere 2021 Nov 26;282:130991. Epub 2021 May 26.

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, China. Electronic address:

Phthalates are non-persistent chemicals used in products of daily necessities. The evidence on the relationship of prenatal phthalates exposure and preterm birth remain uncertain and dimed. We Searched Cochrane, EMBASE, PubMed and Qvid Medline and selected studies according to a priori defined inclusion criteria. A total of 20 relevant studies published before March 31, 2020, were included. The main methods to detect heterogeneity and publication bias of included studies were the Q-statistic and Begg's test. Overall summary estimates indicated positive association of prenatal exposure to di(2-ethylhexyl) phthalate [number of studies (n) = 11, odds ratio (OR) = 1.1; 95% confidence interval (CI): 0.89, 1.4], diethyl phthalate [n = 11, OR = 1.1; 95% CI: 0.92, 1.3], dibutyl phthalate [n = 10, OR = 1.1; 95% CI: 0.77, 1.4], butyl benzyl phthalate [n = 10, OR = 1.0; 95% CI: 0.91, 1.2], diisobutyl phthalate [n = 9, OR = 1.1; 95% CI: 0.92, 1.3], diisononyl phthalate [n = 4, OR = 1.1; 95% CI: 0.85, 1.3], and phthalates were negatively associated with gestational age except di(2-ethylhexyl) phthalate and diisononyl phthalate. Most of them were not statistically significant. Subgroup analysis indicated that the heterogeneity was mainly found in the studies conducted in China and matrix collected at first trimester of pregnancy. Substantial heterogeneity and inconsistency of research methods may lead to inconsistent results of maternal phthalates exposure with preterm birth. We recommend a multicenter cohort study with a consistent approach to unravel the complex associations of prenatal phthalates exposure with birth outcomes.
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http://dx.doi.org/10.1016/j.chemosphere.2021.130991DOI Listing
November 2021

The Expression Characteristics of NPF Genes and Their Response to Vernalization and Nitrogen Deficiency in Rapeseed.

Int J Mol Sci 2021 May 6;22(9). Epub 2021 May 6.

School of Agricultural Sciences, Zhengzhou University, Zhengzhou 450001, China.

The () genes, initially characterized as nitrate or peptide transporters in plants, are involved in the transport of a large variety of substrates, including amino acids, nitrate, auxin (IAA), jasmonates (JAs), abscisic acid (ABA) and gibberellins (GAs) and glucosinolates. A total of 169 potential functional genes were excavated in , and they showed diversified expression patterns in 90 different organs or tissues based on transcriptome profile data. The complex time-serial expression changes were found for most functional genes in the development process of leaves, silique walls and seeds, which indicated that the expression of () genes may respond to altered phytohormone and secondary metabolite content through combining with promoter element enrichment analysis. Furthermore, many genes were detected to respond to vernalization with two different patterns, and 20 genes responded to nitrate deficiency. These results will provide useful information for further investigation of the biological function of genes for growth and development in rapeseed.
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http://dx.doi.org/10.3390/ijms22094944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125141PMC
May 2021

Expression and mechanism of exosome-mediated A FOXM1 related long noncoding RNA in gastric cancer.

J Nanobiotechnology 2021 May 10;19(1):133. Epub 2021 May 10.

Department of Oncology, Tongji Hospital, Tongji University School of Medicine, No. 389, Putuoxincun Rd., Shanghai, 200065, China.

Background: Forkhead box protein M1 (FOXM1) is an oncogene regulating tumor growth and metastasis. Exosome was suggested to mediate cell communication by delivering active molecules in cancers. However, the existence of FOXM1 in circulating exosomes and the role of exosome FOXM1 in gastric cancer (GC) were not clear. This study aims to investigate the potential role of FOXM1 related long noncoding RNA (FRLnc1) in exosomes in GC.

Results: The prepared CD63 immunomagnetic beads (CD63-IMB) had the characteristics of good dispersity and high magnetic response. The isolated exosomes were presented with elliptical membranous particles under a transmission electron microscope (TEM), with the particle size of 89.78 ± 4.8 nm. Western blot (WB) results showed that the exosomes were rich in CD9 and CD81. The Dil-labeled exosomes were distributed around cytoplasm and nucleus of cells by imaging flow cytometry (IFC) analysis. The results of quantitative real-time PCR (qRT-PCR) revealed that the FRLnc1 expressions were up-regulated in GC cells, tumor tissues, and serum of GC patients. An obviously up-regulated FRLnc1 expression was found in serum exosomes of GC patients. Up-regulation of FRLnc1 expression was closely correlated to lymph node metastasis (LNM) and TNM stage with the combination of relevant clinicopathological parameter analysis. The in vitro functional analyses demonstrated that FRLnc1 knockdown by RNA interference suppressed cell proliferation and migration in HGC-27 cells, whereas FRLnc1 overexpression promoted cell proliferation and migration in MKN45 cells. After exosome treatment, the FRLnc1 expression was significantly increased in MKN45 cells, and the MKN45 cells showed increased ability of proliferation and migration.

Conclusion: GC cells-derived exosomes played roles in promoting the growth and metastasis of GC by transporting FRLnc1, suggesting that FRLnc1 in the exosomes may be a potential biomarker for the diagnosis and treatment of GC. The delivery of FRLnc1 by the exosomes may provide a new way for the treatment of GC. Trial registration 2020-KYSB-094. Registered 23 March 2020-Retrospectively registered.
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http://dx.doi.org/10.1186/s12951-021-00873-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111998PMC
May 2021

Preventive and therapeutic significance of octreotide combined with lansoprazole on post-ERCP pancreatitis and its effect on serum amylase, inflammatory factors and immune function.

Exp Ther Med 2021 Mar 22;21(3):251. Epub 2021 Jan 22.

Endoscopy Center, Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), Shaoxing, Zhejiang 312000, P.R. China.

The study aimed to investigate the preventive and therapeutic significance of octreotide combined with lansoprazole on post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) and its effects on serum amylase (AMS), inflammatory factors and immune function. A total of 132 patients who underwent ERCP in Shaoxing People's Hospital (Shaoxing, China) were enrolled in the study and allocated into two groups: The study group (octreotide plus lansoprazole, 68 cases) and the control group (octreotide alone, 64 cases). The incidence of PEP and post-ERCP hyperamylasemia (PEH), the concentrations of serum AMS, interleukin-17 (IL-17) and tumor necrosis factor-α (TNF-α), as well as the T-lymphocyte population in peripheral blood were detected. The AMS levels in the study group were significantly lower than those in the control group at 6 and 24 h after treatment (P<0.001). The incidence of PEP and PEH, symptom disappearance time and hospital stay in the study group were significantly lower than those in the control group after treatment (P<0.05). The levels of IL-17 and TNF-α in the study group were significantly lower than those in the control group after treatment (all P<0.05). The percentage of CD3, CD4, CD8 cells and the ratio of CD4/CD8 in the study group were significantly higher than those in the control group after treatment (all P<0.05). The results indicated that octreotide combined with lansoprazole reduces AMS levels and the incidence of PEP, alleviates inflammation and improves the immune function.
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http://dx.doi.org/10.3892/etm.2021.9682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851608PMC
March 2021

A circGLIS3/miR-644a/PTBP1 positive feedback loop promotes the malignant biological progressions of non-small cell lung cancer.

Am J Cancer Res 2021 1;11(1):108-122. Epub 2021 Jan 1.

Department of Oncology, Tongji Hospital of Tongji University Shanghai, China.

Non-small cell lung cancer (NSCLC) is a severe cancer which critically threatens human health in the world. Circular RNAs (circRNAs) are non-coding RNAs that involve in cancer progression. We want to explore the roles of circRNAs in NSCLC in this study. In current study, circGLIS3 was found to be highly expressed in NSCLC tissues and cell lines and high circGLIS3 level was correlated to malignant characteristics and poor prognosis of NSCLC. Functional experiments suggested that circGLIS3 promoted proliferation, migration and invasion and arrested apoptosis of NSCLC cells in vitro. CircGLIS3 also participated in the in vivo process by accelerate NSCLC tumor growth and metastasis. Mechanistically, circGLIS3 could sponging multiple anti-cancer miRNAs including miR-526b, miR-198, miR-498 and miR-664a. Here, we for the first time confirmed that miR-644a was downregulated and functioned as a tumor suppression gene in NSCLC. In addition, we found PTBP1 as a novel target of miR-644a and circGLIS3 could raise the expression of PTBP1 via miR-644a. And PTBP1 could bind to the flanking introns of circGLIS3 and thereby promoting looping of circGLIS3. In conclusion, CircGLIS3 functions as an oncogene via sponging multiple tumor-suppressive miRNAs in NSCLC. A circGLIS3/miR-644a/PTBP1 positive feedback loop exists in the tumorigenesis and development of NSCLC.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7840707PMC
January 2021

A Pilot Study for Forgiveness Intervention in Adolescents With High Trait Anger: Enhancing Empathy and Harmony.

Front Psychol 2020 23;11:569134. Epub 2020 Dec 23.

Personnel Department, Suzhou Vocational Institute of Industrial Technology, Suzhou, China.

Forgiveness interventions benefit victims' mental health, reduce levels of anger, and promote forgiveness. However, forgiveness interventions are rarely used to improve the offender's anger and mental health, especially in specific situations such as juvenile correctional facilities. The offender is often also a victim, and reducing the offender's excessive anger may prevent or decrease the likelihood of future interpersonal violence. This study examined the effects of forgiveness interventions on anger, forgiveness, empathy, and harmony of juvenile delinquents with high levels of trait anger. Eighteen adolescents with trait anger in a juvenile correctional facility volunteered to participate in group counseling. A pretest-posttest method of quasi-experimental design was used, with 8 participants in the intervention group and 10 in the control group; the intervention group received forgiveness group counseling, and the control group did not. The results revealed that the intervention group had significantly higher scores for forgiveness, empathy, and harmony than the control group, although no significant differences in the scores of state and trait anger were found. The forgiveness intervention had significantly improved the levels of forgiveness toward specific perpetrators of childhood victimization for the juvenile delinquents with high levels of trait anger, raising their levels of empathy and harmony; there was no significant increase in trait anger. The findings indicated that forgiveness intervention provides an effective way to improve the positive mental strength of adolescents with high levels of trait anger.
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http://dx.doi.org/10.3389/fpsyg.2020.569134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7785983PMC
December 2020

Tumor-specific lytic path "hyperploid progression mediated death": Resolving side effects through targeting retinoblastoma or p53 mutant.

World J Clin Oncol 2020 Nov;11(11):854-867

Department of Research and Development, Bio-Synthesis, Lewisville, TX 75057, United States.

A major advance was made to reduce the side effects of cancer therapy the elucidation of the tumor-specific lytic path "hyperploid progression-mediated death" targeting retinoblastoma (Rb) or -mutants defective in G1 DNA damage checkpoint. The genetic basis of human cancers was uncovered through the cloning of the tumor suppressor gene. It encodes a nuclear DNA-binding protein whose self-interaction is regulated by cyclin-dependent kinases. A 3D-structure of Rb dimer is shown, confirming its multimeric status. Rb assumes a central role in cell cycle regulation and the "Rb pathway" is universally inactivated in human cancers. Hyperploidy refers to a state in which cells contain one or more extra chromosomes. Hyperploid progression occurs due to continued cell-cycling without cytokinesis in G1 checkpoint-defective cancer cells. The evidence for the triggering of hyperploid progression-mediated death in RB-mutant human retinoblastoma cells is shown. Hence, the very genetic mutation that predisposes to cancer can be exploited to induce lethality. The discovery helped to establish the principle of targeted cytotoxic cancer therapy at the mechanistic level. By triggering the lytic path, targeted therapy with tumor specificity at the genetic level can be developed. It sets the stage for systematically eliminating side effects for cytotoxic cancer therapy.
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http://dx.doi.org/10.5306/wjco.v11.i11.854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7701912PMC
November 2020

Electrochemically Tuned Oxidative [4+2] Annulation and Dioxygenation of Olefins with Hydroxamic Acids.

Angew Chem Int Ed Engl 2021 02 9;60(6):3182-3188. Epub 2020 Dec 9.

State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, P. R. China.

This work represents the first [4+2] annulation of hydroxamic acids with olefins for the synthesis of benzo[c][1,2]oxazines scaffold via anode-selective electrochemical oxidation. This protocol features mild conditions, is oxidant free, shows high regioselectivity and stereoselectivity, broad substrate scope of both alkenes and hydroxamic acids, and is compatible with terpenes, peptides, and steroids. Significantly, the dioxygenation of olefins employing hydroxamic acid is also successfully achieved by switching the anode material under the same reaction conditions. The study not only reveals a new reactivity of hydroxamic acids and its first application in electrosynthesis but also provides a successful example of anode material-tuned product selectivity.
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http://dx.doi.org/10.1002/anie.202012209DOI Listing
February 2021

One-pot synthesis of Mn-Fe bimetallic oxide heterostructures as bifunctional electrodes for efficient overall water splitting.

Nanoscale 2020 Oct;12(38):19992-20001

School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, People's Republic of China.

The design of Earth-abundant and cost-effective electrocatalysts for highly active and stable electrochemical water splitting in practical production is the primary demand. Herein, bimetallic oxides anchored to three-dimensional (3D) porous conductive nickel foam (NF) are constructed using a simple in situ hydrothermal method for efficient overall water splitting. The vertically aligned Mn3O4/Fe2O3 heterojunction nanosheets have synergy between hierarchical metal oxides and heterogeneous interface, and show excellent performance toward the oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) in an alkaline environment. By adjusting the molar ratio of Fe : Mn, the morphology, composition and electronic structure of MnFeO-NF-x composites (x represents the ratio of Fe : Mn) can be adjusted to exhibit diverse catalytic activities. In particular, MnFeO-NF-0.4 (0.4 indicates the Fe : Mn ratio of 0.4 : 1) and MnFeO-NF-0.8 display outstanding performance with ultralow overpotentials of 157 mV for the OER and 64 mV for the HER to achieve a current density of 10 mA cm-2, respectively. Furthermore, MnFeO-NF-0.4 and MnFeO-NF-0.8 are assembled into a water splitting electrolyzer, which can reach a current density of 10 mA cm-2 with a low voltage of 1.59 V. Interestingly, Mn-M (M = Co, Ni, and Mo) products can be obtained easily by using different metal salts, indicating the universality of the current one-pot hydrothermal method.
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http://dx.doi.org/10.1039/d0nr05864eDOI Listing
October 2020

[email protected] nanoflower in situ grown on copper foam at room temperature as an excellent oxygen evolution electrocatalyst.

Chem Commun (Camb) 2020 Oct 15;56(82):12339-12342. Epub 2020 Sep 15.

School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, P. R. China.

Herein, we have synthesized successfully a three-dimensional/two dimensional (3D/2D) core-shell [email protected] nanoflower on copper foam at room temperature. Remarkably, by virtue of rich active sites and vacancies, large surface area, high conductivity and close contact with the electrolyte, the [email protected] catalyst exhibits superior stability and oxygen evolution reaction performance.
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http://dx.doi.org/10.1039/d0cc04893cDOI Listing
October 2020

Independent Tuning of Nano-Ligand Frequency and Sequences Regulates the Adhesion and Differentiation of Stem Cells.

Adv Mater 2020 Oct 20;32(40):e2004300. Epub 2020 Aug 20.

Department of Biomicrosystem Technology, Korea University, Seoul, 02841, Republic of Korea.

The native extracellular matrix (ECM) can exhibit heterogeneous nano-sequences periodically displaying ligands to regulate complex cell-material interactions in vivo. Herein, an ECM-emulating heterogeneous barcoding system, including ligand-bearing Au and ligand-free Fe nano-segments, is developed to independently present tunable frequency and sequences in nano-segments of cell-adhesive RGD ligand. Specifically, similar exposed surface areas of total Fe and Au nano-segments are designed. Fe segments are used for substrate coupling of nanobarcodes and as ligand-free nano-segments and Au segments for ligand coating while maintaining both nanoscale (local) and macroscale (total) ligand density constant in all groups. Low nano-ligand frequency in the same sequences and terminally sequenced nano-ligands at the same frequency independently facilitate focal adhesion and mechanosensing of stem cells, which are collectively effective both in vitro and in vivo, thereby inducing stem cell differentiation. The Fe/RGD-Au nanobarcode implants exhibit high stability and no local and systemic toxicity in various tissues and organs in vivo. This work sheds novel insight into designing biomaterials with heterogeneous nano-ligand sequences at terminal sides and/or low frequency to facilitate cellular adhesion. Tuning the electrodeposition conditions can allow synthesis of unlimited combinations of ligand nano-sequences and frequencies, magnetic elements, and bioactive ligands to remotely regulate numerous host cells in vivo.
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http://dx.doi.org/10.1002/adma.202004300DOI Listing
October 2020

Pooled analysis of hepatic inflammatory angiomyolipoma.

Clin Res Hepatol Gastroenterol 2020 11 29;44(6):e145-e151. Epub 2020 May 29.

Department of Liver Surgery and Organ Transplantation, Changzheng Hospital, Navy Medical University, Shanghai, 200003, China. Electronic address:

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http://dx.doi.org/10.1016/j.clinre.2020.04.005DOI Listing
November 2020

Supportive care and unmet needs in patients with melanoma: a mixed-methods systematic review.

Support Care Cancer 2020 Aug 27;28(8):3489-3501. Epub 2020 Apr 27.

School of Nursing and Cancer and Palliative Care Outcomes Centre, Queensland University of Technology, Brisbane, Australia.

Purpose: Understanding the supportive care and unmet care needs of patients with melanoma is essential for informing the development or evaluation of supportive care services and interventions for patients with melanoma.

Methods: Three electronic databases (CINAHL, Medline and PsycINFO) were searched from 2000 to November 2019 to identify eligible quantitative and qualitative studies. The quality of evidence was assessed using the Mixed Methods Appraisal Tool.

Results: Fourteen studies (10 quantitative, three qualitative and one mixed-methods) were included. Informational care and unmet needs were the most commonly reported in patients with melanoma, followed by psychological, then social and physical. Findings were consistent between quantitative and qualitative studies; however, findings from qualitative data complimented those from quantitative data by providing more depth and insight into the prevalence, effects and associations of the different care needs. Patients' care and unmet needs were found to also be present all throughout their cancer journey and vary according to the stage throughout.

Conclusion: Melanoma-specific care and unmet care needs were identified most commonly in the informational domain, followed by psychological, social and physical domains. Oncology practitioners should consider enhancing their supportive care interventions throughout the journey of patient with melanoma to reduce or address their unmet needs. The results of this mixed-methods systematic review warrant further research using robust study designs, melanoma-specific validated outcome measures and complete reporting of data in terms of disease stage.
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http://dx.doi.org/10.1007/s00520-020-05464-3DOI Listing
August 2020

Risk of adverse events in advanced hepatocellular carcinoma with immune checkpoint therapy: A systematic review and meta-analysis.

Clin Res Hepatol Gastroenterol 2020 11 16;44(6):845-854. Epub 2020 Apr 16.

Department of Liver Surgery and Organ Transplantation, Naval Medical University, Changzheng Hospital, 415 Fengyang Road, Huangpu District, 200003 Shanghai, PR China. Electronic address:

Aims: To evaluate risk of adverse events (AEs) in advanced hepatocellular carcinoma (AHCC) with immune checkpoint therapy in this setting.

Methods: A systematic search of original articles published until November 2019 was performed using PubMed, Embase, Web of Science, and the Cochrane Central Register of Controlled Trials. And a meta-analysis was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement.

Results: A total of eight studies, including 597 patients, met the eligibility criteria. The median cohort size of patients was 75 (range: 18-267). The pooled incidence rates of grade≥3 AEs and fatal adverse events (FAEs) at last follow-up were 20.87 per 100 person-years (95% CI: 11.00-39.59, I=91.0%) and 4.98 per 100 person-years (95% CI: 1.83-13.56, I=82.8%). Subgroup analyses showed that pembrolizumab had a lower risk of grade≥3 AEs, but a higher risk of FAEs, when compared with nivolumab and tremelimumab. Meta-regression showed significant correlation between grade≥3 AEs rate and proportion of Child-Pugh A stage. Fatigue (16.9%), adrenal insufficiency (8.5%) and rash (6.8%) were involved in common non-laboratory AEs.

Conclusions: Immune checkpoint therapy significantly increases the risk of AEs in AHCC patients. And the risk of grade≥3 AEs is associated with Child-Pugh classification. Future retrospective analyses and prospective cohort studies are warranted to evaluate the safety of immune checkpoint therapy in AHCC.
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http://dx.doi.org/10.1016/j.clinre.2020.02.012DOI Listing
November 2020

Feasibility of using narrow band imaging international colorectal endoscopic classification for diagnosing colorectal neoplasia in China: A multicenter pilot observational study.

J Dig Dis 2020 Feb;21(2):88-97

Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Shanghai Institute of Digestive Disease, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Objective: We aimed to investigate whether Chinese endoscopists without narrow-band imaging (NBI) experiences could achieve high accuracy in the real-time diagnosis of colorectal polyps using NBI International Colorectal Endoscopic (NICE) classification after web-based training.

Methods: Altogether 15 endoscopists from five centers with no NBI experiences followed a short, web-based training program on the NICE classification and took web-based test. Their performances were compared with 15 matched experienced endoscopists with no NBI experience who received no NBI training. These 15 trained endoscopists then made real-time diagnoses of colorectal neoplasia. A logistic regression was used to assess potential predictors of diagnostic performance.

Results: Compared with those who received no training, trained endoscopists achieved comparable overall accuracy (85.3% vs 83.1%, P = 0.408) and accuracy at a high-confidence level (87.0% vs 86.0%, P = 0.670), but had a higher confidence rate (86.1% vs 83.7%, P = 0.004) for the diagnosis of neoplasia. Real-time diagnostic accuracy, sensitivity and specificity were 94.3% (95% confidence interval [CI] 91.5%-96.2%), 96.2% (95% CI 93.4%-97.9%) and 85.3% (95% CI 74.8%-92.1%) at high-confidence level. The high-confidence level was the strongest predictor of real-time diagnostic accuracy (odds ratio 12.66, P < 0.001).

Conclusions: Web-based training can improve the confidence level of endoscopists in accurately diagnosing colorectal polyps using the NICE classification. Chinese endoscopists can achieve high accuracy in diagnosing colorectal neoplasia at a high confidence level (ClinicalTrials ID: NCT02033980).
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http://dx.doi.org/10.1111/1751-2980.12841DOI Listing
February 2020

Complete duodenal obstruction induced by groove pancreatitis: A case report.

World J Clin Cases 2019 Dec;7(23):4106-4110

Department of Hepatobiliary Surgery, Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), Shaoxing 312000, Zhejiang Province, China.

Background: Groove pancreatitis (GP) is a type of chronic pancreatitis occurring in an anatomic area between the duodenum, head of the pancreas, and common bile duct. Duodenal obstruction is always caused by malignant pancreatic diseases, such as pancreatic head carcinoma, while is rarely induced by benign pancreatic diseases, such as pancreatitis.

Case Summary: A 39-year-old man presented with a 1-mo history of upper abdominal discomfort. His concomitant symptoms were abdominal distension, postprandial nausea, and vomiting. Contrast-enhanced computed tomography of the abdomen showed thickening of the intestinal wall with enhancement of the descending segment of the duodenum, which could not be clearly differentiated from the head of the pancreas. Upper gastrointestinal radiographs and gastrointestinal endoscopy showed a complete obstruction of the descending duodenum. An operation found that a 3-cm mass was located in the "groove part" of the pancreas and oppressing the descending duodenum. Pancreaticoduodenectomy was performed to relieve the obstruction and thoroughly remove the pancreatic lesions. The pathologic diagnosis was pancreatitis. The patient had an uneventful recovery with no complications.

Conclusion: Because of the special location and the contracture induced by long-term chronic inflammation, our case reminds surgeons that some benign pancreatic diseases, such as GP, can also present with symptoms similar to those of pancreatic cancer. This knowledge can help to avoid an unnecessary radical operation.
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http://dx.doi.org/10.12998/wjcc.v7.i23.4106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906566PMC
December 2019

Cation Channel Transient Receptor Potential Vanilloid 4 Mediates Topography-Induced Osteoblastic Differentiation of Bone Marrow Stem Cells.

ACS Biomater Sci Eng 2019 Dec 22;5(12):6520-6529. Epub 2019 Nov 22.

Micro/nanotopographies (MNTs) have been reported to enhance the osseointegration of biomaterials and modulate cell functions, but the underlying mechanisms are incompletely understood. We hypothesized that transient receptor potential vanilloid 4 (TRPV4) may mediate the topographically induced osteoblastic differentiation of bone marrow stem cells (BMSCs) by regulating the NFATc1 and Wnt/β-catenin signaling. To test this hypothesis, murine BMSCs were cultured on polished titanium (Ti) discs (PT) and Ti discs carrying titania nanotubes (i.e., MNTs) with diameters of ∼30 and ∼100 nm (termed TNT-30 and TNT-100, respectively). It was found that the MNTs (in particular TNT-100) promoted the expression and activation of TRPV4. Inhibition of TRPV4 in BMSCs cultured on TNT-100 reduced the expression of osteoblastic genes and the gene expression and protein levels of NFATc1 and Wnt3a/β-catenin and also decreased nuclear translocation of NFATc1 and β-catenin (all vs uninhibited BMSCs). Conversely, activation of TRPV4 in BMSCs cultured on PT increased the expression of the osteoblastic gene and the gene expression and protein level of NFATc1 and Wnt3a/β-catenin and also enhanced the nuclear translocation of NFATc1 and β-catenin (all vs unactivated BMSCs). These differences suggest that the MNTs promoted TRPV4 expression and activation to enhance intracellular Ca, which further increased the nuclear translocation of NFATc1 and stimulated the Wnt/β-catenin signaling, thus leading to upregulated expression of osteoblastic genes. These results indicate TRPV4 to be a mediator in MNT-induced osteoblastic differentiation of BMSCs.
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http://dx.doi.org/10.1021/acsbiomaterials.9b01237DOI Listing
December 2019

Recent Developments in Lead-Free Double Perovskites: Structure, Doping, and Applications.

Chem Asian J 2020 Jan 16;15(2):242-252. Epub 2019 Dec 16.

Department of Chemistry, National (Taiwan) University, Taipei, 106, Taiwan.

Lead-free perovskite structures have been recently attracting considerable attention because of their eco-friendly nature and properties, such as their lead-based structure. In this work, we reviewed the lead-free double perovskite (LFDP) structure because of its unique electronic dimensions, chemical stability, and substitutional chemistry compared with other lead-free structures. We highlighted the recent progress on crystal structure prediction, synthesis methods, metal dopants, and ligand passivation on LFDPs. LFDPs are useful for several applications, such as solar cells, light-emitting diodes, degradation of photocatalytic dyes, sensors, and X-ray detectors. This report provides a summary of recent progress as a reference for further research on lead-free perovskite structures.
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http://dx.doi.org/10.1002/asia.201901510DOI Listing
January 2020

Identification and Validation of Plasma Metabolomics Reveal Potential Biomarkers for Coronary Heart Disease.

Int Heart J 2019 Nov 31;60(6):1387-1397. Epub 2019 Oct 31.

Department of Thoracic Surgery, Harbin Medical University Cancer Hospital.

Coronary heart disease (CHD) is a prevalent and chronic life-threatening disease. However, there is no reliable way for early diagnosis and prevention of CHD so far. The precise molecular pathological mechanism of CHD remains obscure. Therefore, developing novel biomarkers is urgently needed.In order to evaluate the potential of untargeted plasma metabolomics in biomarker discovery for characterizing CHD, plasma metabolites from patients newly diagnosed with CHD and controls were profiled using liquid chromatography quadrupole time-of-flight mass spectrometry. Differential metabolites were identified using both univariate and multivariate statistical analyses. Metabolites with significant changes were subjected to binary logistic regression analysis, and a CHD prediction model was established. A total of 28 differential plasma metabolites were identified, of which the concentrations of 11 increased significantly and those of 17 decreased significantly in patients with CHD compared with controls. The altered metabolic pathways included reduced phospholipid metabolism, increased monoglyceride metabolism, and abnormal fatty acid metabolism. Furthermore, binary logistic regression showed that nine metabolites could be used as potential plasma biomarkers for the diagnosis of CHD. The prediction model based on these nine metabolites was then tested with an independent cohort of samples (area under the curve = 0.929).Our plasma metabolomics study not only yielded fundamental insights into dysregulated metabolism in CHD but also presented a combinatorial biomarker that might support the clinical diagnosis of CHD.
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http://dx.doi.org/10.1536/ihj.19-059DOI Listing
November 2019

Characterization of thermo-oxidative behavior of ethylcellulose oleogels.

Food Chem 2020 Feb 5;305:125470. Epub 2019 Sep 5.

Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Biological Science and Engineering, Fuzhou University, Fuzhou 350116, PR China; The School of Food and Chemical Engineering, Beijing Technology & Business University (BTBU), Beijing 100048, PR China. Electronic address:

The thermo-oxidative behavior crucial to the applicability of ethylcellulose (EC) oleogels is characterized. Not only did we take into account the composition of the gel network in relation to textural attributes, but also the dynamic chemical changes occurred during formation, heating, and holding of the gels. EC oleogel oxidative stability showed that at 6.0% EC100 concentration in the oleogels the movement of liquid oil trapped in the gel network was hindered by its high viscosity and stable gel network, thus retarding oxidation. Processing temperature ≤ 120 °C for <2 h was recommended when incorporated in food systems to minimize oxidation. As for the measurement of oxidative stability in general, p-AnV was found suitable in depicting oxidation of EC oleogels. Meanwhile, both R and R acquired from H NMR spectra could serve as reliable oxidative indicators to gauge total oxidation of EC oleogels during storage.
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http://dx.doi.org/10.1016/j.foodchem.2019.125470DOI Listing
February 2020
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