Publications by authors named "Hong Chen"

3,863 Publications

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Identification of the Main Active Components and Mechanism of Wang Bi Tablet in Treating Rheumatoid Arthritis Based on Integrative Pharmacology.

Front Pharmacol 2021 4;12:669551. Epub 2021 Jun 4.

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.

Wang Bi tablet (WBT) is used to treat rheumatoid arthritis (RA) in China. We employed integrative pharmacology, including rapid analysis of chemical composition, pharmacological experiment, and network pharmacology analysis, to elucidate the active components and mechanism underlying the effect of WBT against RA. The chemical fingerprint of WBT was revealed by UPLC-QTOF-MS/MS, and the chemical composition was identified. The anti-inflammatory effect of WBT was evaluated in TNF-α-stimulated RAW264.7 cells by ELISA and transcriptome sequencing. Network pharmacology analysis, functional enrichment analysis, and network visualization were performed. A total of 293 chemical constituents were preliminarily identified or tentatively characterized in WBT extract, and they effectively inhibited inflammatory response in TNF-α-stimulated RAW264.7 cells. Forty-eight key active constituents were identified based on high-frequency binding to hub targets and their corresponding targets number. Next, 135 corresponding hub genes, which may be the putative targets of WBT in treating RA, were selected. Functionally, the putative targets were significantly associated with the inflammatory immune response regulation module, energy metabolism regulation module, and cell function regulation module, corresponding to the traditional efficacy of WBT. In summary, this study revealed, for the first time using integrative pharmacology, that WBT may attenuate RA through the inflammation-immune regulation system.
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http://dx.doi.org/10.3389/fphar.2021.669551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8213436PMC
June 2021

Oxygen Vacancy-Driven Reversible Free Radical Catalysis for Environment-adaptive Cancer Chemodynamic Therapy.

Angew Chem Int Ed Engl 2021 Jun 17. Epub 2021 Jun 17.

Hunan University, College of Chemistry and Chemical Engineering, Department of Chemistry, 208 Yifu building, 410082, Changsha, CHINA.

Amplifying free radical production by chemical dynamic catalysis to cause oxidative damage to cancer cells has received extensive interest for cancer-specific therapy. The major challenge is inevitable negative modulation on the tumor microenvironment (TME) by these species, hindering durable effectiveness. Here we show for the first time an oxygen vacancy - rich Bi-based regulator that allows environment-adaptive free radical catalysis. Specifically, the regulator catalyzes production of highly toxic O 2 •- and • OH in cancer cells via logic enzymatic reactions, yet scavenges accumulation of free radicals and immunosuppressive mediators in TME-associated noncancerous cells. Atomic-level mechanistic studies reveal that such dual-modal regulating behavior is dominated by oxygen vacancies that well fit for free radical catalytic kinetics, along with distinguished cellular fates of this regulator. With this smart regulator, a "two birds with one shot" cancer dynamic therapy can be expected.
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http://dx.doi.org/10.1002/anie.202107556DOI Listing
June 2021

Association of Body Fat Percentage with Time in Range Generated by Continuous Glucose Monitoring during Continuous Subcutaneous Insulin Infusion Therapy in Type 2 Diabetes.

J Diabetes Res 2021 28;2021:5551216. Epub 2021 May 28.

Department of Endocrinology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282 Guangdong, China.

Background: Obesity is a crucial risk factor associated with type 2 diabetes mellitus (T2DM). Excessive accumulation of body fat may affect the glycemia control in T2DM. This study investigated the relationship between body fat percentage and time in range (TIR) assessed by continuous glucose monitoring (CGM) during short-term continuous subcutaneous insulin infusion (CSII) therapy in T2DM patients.

Method: A total of 85 T2DM patients were recruited in this cross-sectional study. All participants underwent 72 h CGM period during short-term CSII therapy. TIR was defined as the percentage of time spent within the target glucose range of 3.9-10.0 mmol/L. Body composition was measured using bioelectrical impedance analysis (BIA) and overfat was defined as an amount of body fat of at least 25% of total body mass for men or at least 30% for women. Multiple linear regression models were used to evaluate the independent association of body fat percentage with TIR after adjusting for confounding factors.

Results: Compared with normal fat T2DM patients, individual with a higher body fat percentage exhibited lower levels of TIR ( = 0.004) and higher 72 h mean blood glucose (72 h MBG) ( = 0.001) during short-term CSII treatment. The prevalence of overfat assessed by body fat percentage decreased with the ascending TIR tertiles ( < 0.05). Multiple linear regression analysis indicated that body fat percentage was significantly associated with TIR independent of age, gender, diabetes duration, HbA1c, and BMI ( = 0.043).

Conclusions: Body fat percentage was significantly associated with TIR in T2DM during short-term CSII therapy. Reduction of body fat may be an important therapeutic target to improve glycemic control in high body fat T2DM patients, who may benefit less from intensive insulin treatment.
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http://dx.doi.org/10.1155/2021/5551216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8177984PMC
May 2021

Vitamin C Inhibits the Metabolic Changes Induced by Tet1 Insufficiency Under High Fat Diet Stress.

Mol Nutr Food Res 2021 Jun 15:e2100417. Epub 2021 Jun 15.

Y. Yuan, X. Chen, Y. Sun, Y. Fan, L. Zheng, Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, 430072, China.

Scope: DNA methylation contributes to obesity, but the role of the DNA demethylase ten-eleven translocation protein 1 (Tet1) in obesity remains unclear. Vitamin C is a cofactor for the Tet family of proteins, but whether vitamin C can be used to treat obesity via Tet1 awaits clarification.

Methods And Results: Tet1 and Tet1 mice were fed a high fat diet (HFD). Higher weight gain and more severe hepatic steatosis, accompanied by reduced 5-hydromethylcytosine (5hmC) levels, were found in the white adipose tissue and liver of Tet1 mice. Accumulated lipids were observed in palmitic acid or oleic acid treated primary hepatocytes derived from Tet1 mice, which were rescued by Tet1 overexpression or vitamin C treatment. Bisulfite sequencing revealed higher DNA methylation levels on lipolysis related genes in the liver of Tet1 mice. Notably, oral intake of vitamin C normalized DNA methylation levels, promoted lipolysis and decreased obesity in HFD-fed Tet1 mice.

Conclusions: Our results revealed a novel function of Tet1 in obesity and provided a new mechanism for the beneficial role of vitamin C in metabolic diseases through enhanced Tet1 activity. This article is protected by copyright. All rights reserved.
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http://dx.doi.org/10.1002/mnfr.202100417DOI Listing
June 2021

LINC02535 promotes cell growth in poorly differentiated gastric cancer.

J Clin Lab Anal 2021 Jun 14:e23877. Epub 2021 Jun 14.

Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China.

Background: Abnormal long non-coding RNA (lncRNA) expression plays important roles in gastric cancer. However, the functions of many lncRNAs in poorly differentiated gastric cancer (PDGC) remain unknown.

Methods: Three sets of paired tissues from patients with PDGC were used, and transcriptome sequencing was performed, followed by the construction and sequencing of a library and mapping of the reads. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways and protein-protein interaction (PPI) networks were analysed, and canonical pathway significance was calculated among the differentially expressed genes (DEGs; p < 0.05). Gene expression in 30 paired PDGC specimens and four cell lines was validated through quantitative PCR. Cell proliferation, migration, invasion, apoptosis, and wound healing were analysed.

Results: A total of 499 upregulated DEGs and 627 downregulated DEGs were identified between peritumoral and gastric cancer tissues. The proportions of positive and negative correlations between LINC02535 and the DEGs were 98.40% and 92.66%, respectively, while the Spearman's correlation coefficient was greater than 0.5. The PPI network showed that approximately 73.15% of the top five genes were directly correlated with LINC02535 according to the STRING database. Based on KEGG analysis, the functions of LINC02535 target genes were enriched in signalling pathways related to cancer cell growth. Furthermore, cell function studies showed that LINC02535 upregulation contributed to cell proliferation, migration, invasion, and wound healing and that its inhibition facilitated cell apoptosis.

Conclusion: LINC02535 expression was upregulated in PDGC and contributed to cell proliferation, migration, invasion and wound healing, whereas its inhibition in PDGC facilitated cell apoptosis.
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http://dx.doi.org/10.1002/jcla.23877DOI Listing
June 2021

A Phase I, Randomized, Single-Dose Study to Evaluate the Biosimilarity of HOT-3010 to Adalimumab Among Healthy Chinese Male Subjects.

Front Pharmacol 2021 17;12:646171. Epub 2021 Mar 17.

Phase I Clinical Research Center, The First Hospital of Jilin University, Jilin, China.

This study explored the bioequivalence of a proposed biosimilar HOT-3010 vs. its reference product (adalimumab) among healthy Chinese male subjects. The study also investigated the tolerance, immunogenicity, and pharmacokinetics (PK). A randomized, double-blind, two-arm, parallel study was performed to examine the bioequivalence of HOT-3010 (40 mg) with that of adalimumab (Humira, AbbVie) as a reference drug. The study subjects were followed up for 71 days. PK properties exhibited by HOT-3010 ( = 66) and adalimumab ( = 68) groups were similar. The 90% confidence intervals of the ratios for , AUC , and AUC were observed to be in the range 80-125% on comparing the two groups. For anti-drug antibodies (ADA), the number of subjects found to be positive in the HOT-3010 group and adalimumab group were 29 (43.94%) and 32 (47.06%), whereas 27 (40.91%) and 27 (39.71%) subjects were found to be positive for NAb, respectively. Treatment-related treatment-emergent adverse events (TEAEs) were recorded in 32 subjects each in both the groups, respectively. The PK characteristics and immunogenicity exhibited by HOT-3010 were similar to that of the reference product, adalimumab. The safety profiles were similar in both the treatment groups with mild-moderate adverse effects.
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http://dx.doi.org/10.3389/fphar.2021.646171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190825PMC
March 2021

Microbial community diversity associated with Tibetan kefir grains and its detoxification of Ochratoxin A during fermentation.

Food Microbiol 2021 Oct 3;99:103803. Epub 2021 Apr 3.

College of Food Science and Engineering, Northwest A & F University, Yangling, 712100, China; Laboratory of Quality & Safety Risk Assessment for Agro-products (Yangling), Ministry of Agriculture, Yangling, 712100, China; College of Food Science and Engineering, Northwest University, Xi'an, 710069, China. Electronic address:

Tibetan kefir grains (TKG) are multi-functional starter cultures used in foods and have been applied in various fermentation systems. This study aimed to investigate the microbial community composition of TKG, the detoxification abilities of TKG and their isolates towards common mycotoxins, and the potential for applying TKG and their associated microbial populations to avoid mycotoxin contamination in dairy products. Cultivation-independent high-throughput sequencing of bacterial and fungal rDNA genes indicated that Lactobacillus kefiranofaciens and Kazachstania turicensis were the most abundant bacterial and fungal taxa, respectively. In addition, 27 total isolates were obtained using cultivation methods. TKG removed more than 90% of the Ochratoxin A (OTA) after 24 h, while the isolate Kazachstania unisporus AC-2 exhibited the highest removal capacity (~46.1%). Further, the isolate exhibited good resistance to acid and bile salts environment. Analysis of the OTA detoxification mechanism revealed that both adsorption and degradation activities were exhibited by TKG, with adsorption playing a major detoxification role. Furthermore, the addition of OTA did not affect the microbial community structure of TKG. These results indicate that TKG-fermented products can naturally remove mycotoxin contamination of milk and could potentially be practically applied as probiotics in fermentation products.
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http://dx.doi.org/10.1016/j.fm.2021.103803DOI Listing
October 2021

WNT7B overexpression rescues bone loss caused by glucocorticoids in mice.

FASEB J 2021 Jul;35(7):e21683

Department of Orthopedic Surgery, Washington University School of Medicine, St. Louis, MO, USA.

Glucocorticoids, widely prescribed for anti-inflammatory and immunosuppressive purposes, are the most common secondary cause for osteoporosis and related fractures. Current anti-resorptive and anabolic therapies are insufficient for treating glucocorticoid-induced osteoporosis due to contraindications or concerns of side effects. Glucocorticoids have been shown to disrupt Wnt signaling in osteoblast-lineage cells, but the efficacy for Wnt proteins to restore bone mass after glucocorticoid therapy has not been examined. Here by using two mouse genetic models wherein WNT7B expression is temporally activated by either tamoxifen or doxycycline in osteoblast-lineage cells, we show that WNT7B recovers bone mass following glucocorticoid-induced bone loss, thanks to increased osteoblast number and function. However, WNT7B overexpression in bone either before or after glucocorticoid treatments does not ameliorate the abnormal accumulation of body fat. The study demonstrates a potent bone anabolic function for WNT7B in countering glucocorticoid-induced bone loss.
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http://dx.doi.org/10.1096/fj.202100151RRDOI Listing
July 2021

Antihypertensive and Immunomodulatory Effects of Defatted Corn Germ Hydrolysates: An Study.

Front Nutr 2021 24;8:679583. Epub 2021 May 24.

School of Food and Biological Engineering, Jiangsu University, Zhenjiang, China.

This study investigated the antihypertensive and immunomodulatory effects of defatted corn germ hydrolysates (DCGHs) and their potential regulatory mechanisms. The systolic blood pressure (SBP) of spontaneously hypertensive rats (SHRs) was significantly reduced (10.30%) by the long-term intragastric administration of DCGHs (high doses). Also, there was drastic inhibition of angiotensin-I-converting enzyme (ACE) activity in the lung, kidney, and heart tissues by 24.53, 22.28, and 12.93%, respectively. It could regulate the blood pressure by adjusting the balance between endothelium-derived vasoconstrictor factors and endothelium-derived relaxing factors. Meanwhile, DCGHs enhanced the phagocytosis of mononuclear macrophages, cellular immunity, and humoral immunity of ICR mice by increasing the phagocytic index of mononuclear macrophages (23.71%), ear swelling degree (44.82%), and antibody levels (52.32%). Moreover, it stimulated the release of immunoactive substances (e.g., lysozyme, interferon-γ, immunoglobulin G, and complement 3). Consequently, DCGHs could suitably be used in the formulation of novel functional foods with antihypertensive and immunomodulatory properties.
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http://dx.doi.org/10.3389/fnut.2021.679583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8180860PMC
May 2021

SNP discovery of gene and their associations with growth traits in goats.

Anim Biotechnol 2021 Jun 9:1-7. Epub 2021 Jun 9.

Institute of Cellular and Molecular Biology, Jiangsu Normal University, Xuzhou, China.

AMPK plays an important role in regulating the metabolism of carbohydrate, lipid and protein in an organism, and is considered to be a key regulator of cellular energy homeostasis. In recent years, attention has been drawn to AMPK subunit polymorphisms and their association with economical traits of domestic animals and fowls. PRKAB1 encodes the β1 regulatory subunit of AMPK, and it has been reported that PRKAB1 may be applied in breeding programs of meat-type chicken. To date, the polymorphism of goat PRKAB1 gene and its associations remain unknown. In this paper, the polymorphism of gene was detected in 316 goats of three breeds. A total of four novel single nucleotide polymorphisms (SNPs) of PRKAB1 gene were revealed by sequence analysis. Among them, three were in the coding region (285 C > A, 297 C > A, 309 C > T), and they were all synonymous. One was in the intron (229 A > G). The associations between polymorphic loci and the growth traits of Xuhuai and Haimen goats were analyzed, and significant associations were found in body length index and trunk index ( < 0.05) for Xuhuai breed, while no significant associations in Haimen breed. Our results provide useful information for the improvement and breeding of Chinese native goats.
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http://dx.doi.org/10.1080/10495398.2021.1920426DOI Listing
June 2021

A novel degradable tricalcium silicate/calcium polyphosphate/polyvinyl alcohol organic-inorganic composite cement for bone filling.

J Biomater Appl 2021 Jun 9:8853282211020399. Epub 2021 Jun 9.

College of Physical Science and Technology, Sichuan University, Chengdu, P.R. China.

In this study, tricalcium silicate (CS) calcium/polyphosphate/polyvinyl alcohol organic-inorganic self-setting composites were successfully designed. A variety of tests were conducted to characterize their self-setting properties, mechanical properties, degradation properties, and related biological properties. The composite bone cements showed a short setting time (5.5-37.5 min) with a 5:5-6:4 ratio of CS/CPP to maintain a stable compressive strength (28 MPa). In addition, PVA effectively reduced the brittleness of the inorganic phase. Degradation experiments confirmed the sustainable surface degradation of bone cement. A maximum degradation rate of 49% was reached within 56 days, and the structure remained intact without collapse. Culturing MC3T3 cells with bone cement extracts revealed that the composite bone cements had excellent biological properties . The original extract showed a proliferation promotion effect on cells, whereas most of the other original extracts of degradable bone cements were toxic to the cells. Meanwhile, extracellular matrix mineralization and alkaline phosphatase expression showed remarkable effects on cell differentiation. In addition, a good level of adhesion of cells to the surfaces of materials was observed. Taken together, these results indicate that CS/CPP/PVA composite bone cements have great potential in bone defect filling for fast curing.
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http://dx.doi.org/10.1177/08853282211020399DOI Listing
June 2021

Diagnostic value of susceptibility-weighted imaging for endometrioma: preliminary results from a retrospective analysis.

Acta Radiol 2021 Jun 7:2841851211022495. Epub 2021 Jun 7.

Department of Medical Imaging, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China.

Background: Endometrioma is a common manifestation of endometriosis that can be difficult to diagnose with conventional magnetic resonance imaging (MRI). Susceptibility-weighted imaging (SWI) may be more sensitive than conventional MRI in the detection of chronic, local hemorrhagic disease.

Purpose: To investigate whether signal voids in SWI sequences could be used in the preoperative diagnosis of endometrioma.

Material And Methods: This retrospective study included consecutive female patients with clinically suspected endometrioma. All patients underwent pelvic 3-T MRI (T1- and T2-weighted) and SWI within two weeks before laparoscopy. Two experienced radiologists blinded to the histopathologic/clinical diagnoses interpreted the images together, and any disagreements were resolved by consensus.

Results: The final analysis included 73 patients: 46 patients (mean age=37 years; age range=22-68 years) with 85 endometrioma lesions and 27 patients (mean age=34 years; age range=15-68 years) with 34 non-endometrioid cystic lesions (18 hemorrhagic corpus luteal cysts, three simple cysts, three mucinous cystadenomas, two mature teratomas, and one endometrioid cyst with corpus luteum rupture/hemorrhage). The presenting symptoms for patients with endometrioma were chronic pelvic pain (44.6%), dysmenorrhea (31.9%), infertility (12.8%), dyspareunia (6.4%), and menstrual irregularity (4.3%). MRI identified all 119 lesions observed laparoscopically. SWI visualized punctate or curvilinear signal voids along the cyst wall or within the lesion in 67 of 85 endometriomas (78.8%) and only 3 of 31 non-endometrioid cysts (8.8%).

Conclusion: The use of SWI to look for signal voids in the cyst wall or within the lesion could facilitate the preoperative diagnosis of endometrioma.
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http://dx.doi.org/10.1177/02841851211022495DOI Listing
June 2021

Mechanical and mechanothermal effects of focused ultrasound elicited distinct electromyographic responses in mice.

Phys Med Biol 2021 Jun 7. Epub 2021 Jun 7.

Department of Biomedical Engineering, Washington University in Saint Louis , 4511 Forest Park, St Lousi, Missouri, 63108, UNITED STATES.

The objective of this study was to compare FUS neuromodulation-induced motor responses under two physical mechanisms: mechanical and mechanothermal effects. Mice were divided into two groups. One group was subjected to short-duration FUS stimulation (0.3 s) that induced mechanical effects (mechanical group). The other group underwent long-duration FUS stimulation (15 s) that produced not only mechanical but also thermal effects (mechanothermal group). FUS was targeted at the deep cerebellar nucleus in the cerebellum to induce motor responses, which were evaluated by recording the evoked electromyographic (EMG) signals and tail movements. Brain tissue temperature rise associated with the FUS stimulation was quantified by noninvasive magnetic resonance (MR) thermometry in vivo. Temperature rise was negligible for the mechanical group (0.2 ± 0.1°C) but did rise within the range of 0.6 ± 0.2°C - 3.3 ± 0.9°C for the mechanothermal group. The elongated FUS beam also induced heating in the dorsal brain (below the top skull) and ventral brain (above the bottom skull) along the beam path for the mechanothermal group. Both mechanical and mechanothermal groups achieved successful FUS neuromodulation. EMG response latencies were within the range of 0.03-0.1 s at different intensity levels in the mechanical group. The mechanothermal effect of FUS could induce both short-latency EMG (0.2-1.4 s) and long-latency EMG (8.7-13.0 s) under the same intensity levels as the mechanical group. The different temporal dynamics of evoked EMG suggested that FUS-induced mechanical and mechanothermal effects could evoke different responses in the brain.
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http://dx.doi.org/10.1088/1361-6560/ac08b1DOI Listing
June 2021

The molecular behavior of pyridinium/imidazolium based ionic liquids and toluene binary systems.

Phys Chem Chem Phys 2021 Jun 7;23(23):13300-13309. Epub 2021 Jun 7.

Shandong Sino-Japanese Center for Collaborative Research of Carbon Nanomaterials, College of Chemistry and Chemical Engineering, Instrumental Analysis Center of Qingdao University, Qingdao University, Qingdao 266071, China.

Imidazolium and pyridinium-based ionic liquids (ILs) have attracted increasing attention in the extraction of aromatic VOCs. However, fundamental studies on the mechanism of capturing aromatic VOCs have been less reported. In this work, the interactions between two ILs, 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide (EMIMTFSI) and N-butylpyridinium bis(trifluoromethylsulfonyl)imide (BpyTFSI), and toluene (CHCH), were investigated by using attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR), excess infrared spectroscopy, hydrogen nuclear magnetic resonance (H NMR) spectroscopy and quantum chemical calculations. Some conclusions were obtained as follows: (1) H atoms on EMIMTFSI/BpyTFSI were located above or below the benzene ring and were mainly formed as C2-Hπ bonds and C2,6-Hπ bonds with CHCH, respectively. C-Hπ bonds played a significant role in capturing aromatic compounds. (2) Upon adding CHCH, the two IL-CHCH system's interaction strength was as follows: EMIMTFSI-CHCH > BpyTFSI-CHCH. (3) Since CHCH was unable to disrupt the interactions between cations and anions of ion pairs in the two studied IL-CHCH systems, only ion cluster-CHCH and ion pair-CHCH complexes were observed. This work may provide theoretical insights into the separation mechanism for capturing VOCs.
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http://dx.doi.org/10.1039/d1cp00874aDOI Listing
June 2021

First report of the prevalence and genetic characterization of Giardia duodenalis and Cryptosporidium spp. in Yunling cattle in Yunnan Province, southwestern China.

Microb Pathog 2021 Jun 6;158:105025. Epub 2021 Jun 6.

Key Laboratory of Veterinary Public Health of Yunnan Province, College of Veterinary Medicine, Yunnan Agricultural University, Kunming, Yunnan Province, 650201, PR China. Electronic address:

Yunling cattle is an unique cattle breed distributed in Yunnan Province, southwestern China. It is yet to know whether Yunling cattle are infected with Giardia duodenalis and Cryptosporidium spp.. The objectives of the present study were to investigate the prevalence and characterize the assemblages of G. duodenalis and species of Cryptosporidium spp. in Yunling cattle in Yunnan province. The overall prevalence of G. duodenalis and Cryptosporidium spp. were 10.49% (41/391) and 0.77% (3/391), respectively. The age was considered as the risk factor for Yunling cattle infection with G. duodenalis (χ = 8.082, OR = 2.56, P = 0.004). Two assemblages of G. duodenalis, assemblage A (n = 1) and assemblage E (n = 40), were identified by amplification of the β-giardin (bg) and glutamate dehydrogenase (gdh) gene loci using the nested PCR methods. Furthermore, Cryptosporidium andersoni (n = 1) and Cryptosporidium ryanae (n = 2) were detected by nested PCR targeting the small subunit (SSU) rRNA gene. This is the first report of G. duodenalis and Cryptosporidium spp. in Yunling cattle in China, which provided baseline date for further studies of the prevalence, genetic identity, and public health potential of these parasites in Yunling cattle.
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http://dx.doi.org/10.1016/j.micpath.2021.105025DOI Listing
June 2021

A Biosimilarity Study Between QX001S and Ustekinumab in Healthy Chinese Male Subjects.

Front Pharmacol 2021 18;12:675358. Epub 2021 May 18.

Department of Dermatology, China-Japan Union Hospital of Jilin University, Changchun, China.

To evaluate the tolerance, variability, and pharmacokinetics (PK) of QX001S, a biosimilar for ustekinumab, in healthy Chinese men. One hundred and seventy-eight healthy men were recruited in this randomized, double-blind, single-dose, two-arm, parallel study, and received 45 mg of QX001S or ustekinumab in a single subcutaneous injection. PK, immunogenicity, and tolerance were evaluated in all participants for a period of 113°days. The similarity between the two drugs was determined by comparing the baseline characteristics for each drug. The PK parameters were similar in the two groups: QX001S ( = 89) and ustekinumab ( = 88). The 90% confidence intervals (CIs) for the geometric mean ratio (GMR) of QX001S to the reference (ustekinumab) for the maximum observable serum concentration (C ), area under the curve (AUC) from zero to the final quantifiable concentration (AUC0-t), and AUC from zero to infinity (AUC) were 100.90-118.68%, 98.71-115.26%, and 98.49-115.81%, respectively, which were within the predefined bioequivalence limit of 80.00-125.00%. High inter-subject variability (ranging from 32.0 to 33.5%) was observed. A total of 17 participants (19.1%) in the QX001S group and 36 (40.9%) in the ustekinumab group developed anti-drug antibodies (ADA) after administration. Nevertheless, the ADA did not affect the outcomes of the bioequivalence tests. Adverse reactions were recorded in 38 individuals injected with QX001S and 37 injected with ustekinumab. The most common adverse reactions were upper respiratory infection and elevated alanine aminotransferase. Our study ratified pharmacokinetic biosimilarity between QX001 S and ustekinumab, with high variability between subjects.
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http://dx.doi.org/10.3389/fphar.2021.675358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8167066PMC
May 2021

Effects of pullulan on the biomechanical and anti-collapse properties of dicalcium phosphate dihydrate bone cement.

J Biomater Appl 2021 Jun 1:8853282211020158. Epub 2021 Jun 1.

School of Chemical Engineering, Sichuan University, Chengdu, China.

In this work, a modified dicalcium phosphate dihydrate (DCPD) bone cement with unique biodegradable ability in a calcium phosphate cement system was prepared by the hydration reaction of monocalcium phosphate monohydrate and calcium oxide and integration with pullulan (Pul), a non-toxic, biocompatible, viscous, and water-soluble polysaccharide that has been successfully used to improve defects in DCPD bone cement, especially its rapid solidification, fragile mechanical properties, and easy collapse. The effect of different contents of Pul on the structure and properties of DCPD were also studied in detail. The modified cement was characterised by X-ray diffraction, Fourier-transform infrared spectroscopy, scanning electron microscopy, ultraviolet-visible absorption, X-ray photoelectron spectroscopy analysis, and rheological property measurements. The results indicated that Pul promoted the hydration formation of DCPD, and interface bonding occurred between Pul and DCPD. With increasing content of Pul, the setting time of the DCPD bone cement increased from 2.6 min to 42.3 min, the compressive strength increased from 0 MPa to 20.4 MPa, and the anti-collapse ability also improved owing to the strong interface bonding, implying that the DCPD bone cement improved by Pul has better potential for application in the field of non-loading bone regenerative medicine compared to unmodified DCPD bone cement.
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http://dx.doi.org/10.1177/08853282211020158DOI Listing
June 2021

Construction of Z-scheme g-CN / MnO /GO ternary photocatalyst with enhanced photodegradation ability of tetracycline hydrochloride under visible light radiation.

Environ Res 2021 May 29;200:111427. Epub 2021 May 29.

School of Hydraulic Engineering, Changsha University of Science & Technology, Changsha, 410114, PR China.

A facile wet-chemical method was adopted to synthesize g-CN/MnO/GO heterojunction photocatalyst for visible-light photodegradation of tetracycline hydrochloride (TC). The addition of MnO and GO increased the absorption of visible light and the specific surface area of the photocatalyst. The results of photoluminescence, electrochemical impedance spectroscopy, and photocurrent response indicated that CMG-10 had the lowest electron-hole recombination probability, which was beneficial for the photocatalytic reaction. The ternary photocatalyst exhibited enhanced photoelectric performance and superior photocatalytic activity with 91.4% removal of TC (10 mg/L) under a mere 60 min visible light illumination, which showed enhanced photocatalytic degradation when compared with binary (CM, 77.95%; CG, 78.83%) and single (CN, 55.5%; MnO, 36.41%) photocatalysts. A pH of 6 was optimal for the CMG-10 photocatalytic degradation of TC, and the optimal photocatalyst dosage was 0.5 g/L. Common coexisting ions influenced the removal of TC by influencing the production of active species. The catalyst is stable and reusable with only a 10% reduction in removal efficiency after four cycles. According to the active species analysis, the Z-scheme mechanism was a charge transfer behavior in the composite photocatalyst, which could prevent the recombination of photogenerated carriers. This study presents a photocatalytic approach to the effective removal of TC from water bodies, which provides practical implications to advance the use of photocatalytic technology in the restoration of aqueous environmental pollution.
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http://dx.doi.org/10.1016/j.envres.2021.111427DOI Listing
May 2021

1,25(OH) D attenuates sleep disturbance in mouse models of Lewis lung cancer, in silico and in vivo.

J Cell Physiol 2021 Jun 1. Epub 2021 Jun 1.

Wuxi Medical School, Jiangnan University, Wuxi, Jiangsu, China.

Many clinical studies have reported that patients diagnosed with cancer will suffer from sleep disturbance during their clinical process, especially among lung cancer patients, and this effect will not easily subside. 1,25-dihydroxy-vitamin-D [1,25(OH) D ], the activated form of vitamin D, can participate in neuronal differentiation and prevent damage to the nervous system. However, little is known about the potential therapeutic effects of cancer-related psychiatric symptoms. In light of this, we hypothesized that a low circulating level of vitamin D was related to sleep quality in the presence of a tumor, 1,25(OH) D may be an effective way to ameliorate sleep disturbance and neurochemical alterations along with the cancer progress. Male C57BL/6 mice were implanted with intracranial transmitters to monitor electroencephalogram and were subcutaneously inoculated with Lewis lung cancer cells. The results demonstrated that on Days 19-20, tumor-bearing mice displayed fragmented sleep, shortened wake phase, prolonged sleep in the non-rapid eye movement phase, and the levels of vitamin D-associated genes in the brain had changed a lot compared to control mice. Importantly, 1,25(OH) D treatment really effectively saved the sleep quality of tumor-bearing mice. We further explored and confirmed that 1,25(OH) D repressed tumor-induced neuroinflammation (IL-1β, TNF-α, IL-6, IL-10, IFN-γ, and IL-2), enhanced neurotrophic factors (brain-derived neurotrophic factor [BDNF], glialcellline-derived neurotrophic factor) and 5-HT system in the hippocampus, hypothalamus or cortex. A molecular docking approah manifested the ability of 1,25(OH) D to affect the activity of tryptophan hydroxylase 2 and BDNF. Together, our results suggested that 1,25(OH) D treatment may attenuate sleep disturbance in Lewis lung cancer-bearing mice, and become a promising strategy for treating cancer symptom clusters to ameliorate the quality of life of patients with cancer.
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http://dx.doi.org/10.1002/jcp.30458DOI Listing
June 2021

Procyanidin B2 induces porcine skeletal slow-twitch myofiber gene expression by AMP-activated protein kinase signaling pathway.

Anim Biotechnol 2021 Jun 1:1-10. Epub 2021 Jun 1.

Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, Sichuan, P. R. China.

In this study, our aim is to investigate the effect of dimer procyanidin B2 [epicatechin-(4β-8)-epicatechin] (PB2) on porcine skeletal myofiber gene expression . Our data showed PB2 promoted the protein expression of slow myosin heavy chain (MyHC) in porcine myotubes, concomitant with the increases in mRNA levels of , and . We also found PB2 activated AMPK signaling in porcine myotubes. NRF1 and CaMKKβ that are two important upstream factors of AMPK, and Sirt1 and PGC-1α that are two major downstream factors of AMPK, were also up-regulated by PB2. The mechanism study showed the effect of PB2 on slow-twitch myofiber gene expression was abolished by AMPK inhibitor compound C or by AMPKα1 siRNA. Together, we found PB2 induced porcine skeletal slow-twitch myofiber gene expression by AMPK signaling pathway.
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http://dx.doi.org/10.1080/10495398.2021.1927065DOI Listing
June 2021

Derivation of a Risk Score for High Caries Risk in 3- to 5-year-old Children in Sichuan Province.

Oral Health Prev Dent 2021 Jan;19(1):279-285

Purpose: To explore potential caries risk indicators in 3- to 5-year-old children, and develop a simple risk-score model to screen the children at high risk of caries with decayed, filled, and missing teeth (dmft) > 2.

Materials And Methods: A cross-sectional study involving 2746 children 3 to 5 years of age was conducted in Sichuan province. Children were examined for dmft index, and sociodemographic and behavioural factors were acquried through a questionnaire completed by their caregivers. A prediction model was developed by backward multivariate logistic regression, and its overfitting degree was examined with 5-fold cross-validation. A simple risk-score model was derived to screen the children with dmft > 2 at high risk of caries with the β regression coefficient obtained from the multivariate regression model.

Results: A child's oral health status was identified as the highest risk indicator with a β regression coefficient of 1.093. The mean area under curve (AUC) from the 5-fold cross-validation was 0.7408 (95% CI: 72.21%, 75.95%), with a bias of only ca 1%. This result allowed us to eliminate substantial overfitting of the prediction model. The AUC of the risk scoring system was 0.7455 (95% CI: 72.70%, 76.40%), which indicated good screenability.

Conclusions: This risk score model has the advantages of simplicity, low cost and relatively high accuracy, and is suitable for use in developing countries, especially for primary screening for high risk of caries. It shows that certain child behaviours and parental attitude play an important role in dental caries among preschool children.
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http://dx.doi.org/10.3290/j.ohpd.b1452865DOI Listing
January 2021

Developing a novel magnesium calcium phosphate/sodium alginate composite cement with high strength and proper self-setting time for bone repair.

J Biomater Appl 2021 May 30:8853282211021535. Epub 2021 May 30.

College of Physics, Sichuan University, Chengdu, China.

In this work, novel magnesium calcium phosphate/sodium alginate composite cements were successfully fabricated with a proper setting time (5-24 min) and high compressive strength (91.1 MPa). The physicochemical and biological properties of the cement in vitro were fully characterized. The composite cements could gradually degrade in PBS as the soaking time increase, and the weight loss reached 20.74% by the end of 56th day. The cements could induce the deposition of Ca-P layer in SBF. Cell experiments proved that the extracts of the composite cements can effectively promote the proliferation and differentiation of the mouse bone marrow mesenchymal stem cells (MSCs). These preliminary results indicate that the magnesium calcium phosphate/sodium alginate composite cements could be promising as potential bone repair candidate materials.
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http://dx.doi.org/10.1177/08853282211021535DOI Listing
May 2021

Downregulation of Serum and Distal Ileum Fibroblast Growth Factor19 in Bile Acid Diarrhoea Patients.

Dig Dis Sci 2021 May 26. Epub 2021 May 26.

Nanjing Medical University, Nanjing, 211166, Jiangsu, People's Republic of China.

Background: Bile acid diarrhoea or BAD is a common but little recognised cause of chronic diarrhoea. Few of these patients in China have been diagnosed due to a lack of diagnostic options.

Aims: To clarify the diagnostic value of serum fibroblast growth factor19 (FGF19) in BAD patients.

Methods: We reported on 60 chronic diarrhoea patients and 80 healthy volunteers (HV). Based on the 90th percentile levels of serum 7a-hydroxy-4-cholesten-3-one (C4) of HV, these patients were divided into BAD group (C4 ≥ 90th) and non-bile acid diarrhoea group (NBAD, C4 < 90th). Serum FGF19 in the two clinical groups and HV group were compared, as was distal ileum FGF19 in clinical groups. The diagnostic value of serum FGF19 for BAD was evaluated.

Results: The 90th percentile of serum C4 in HV group was 65.87 ng/ml. Serum FGF19 concentrations in BAD group (Median 69.28 pg/ml; n = 23) were significantly lower than those in HV (Median 122.18 pg/ml; n = 80) and NBAD (Median 129.57 pg/ml; n = 29) groups. FGF19 mRNA of the distal ileum in BAD group, was lower than that in NBAD group, P = 0.002. The rate of FGF19 protein low expression of distal ileum in BAD and NBAD group were 78.3% and 48.3%, P = 0.027. Using an ROC curve, statistical analysis yielded a threshold FGF19 concentration of 117.3 pg/ml (AUC, 0.906; 91.3% sensitivity, 79.3% specificity) for a clinical diagnosis of BAD.

Conclusions: Serum and distal ileum expression of FGF19 significantly decreased in BAD patients. The suggested clinical ranges for serum FGF19 < 117.3 pg/ml has high sensitivity and specificity for BAD patients with a normal structural and histological ileum.
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http://dx.doi.org/10.1007/s10620-021-07042-xDOI Listing
May 2021

A community effort to identify and correct mislabeled samples in proteogenomic studies.

Patterns (N Y) 2021 May 7;2(5):100245. Epub 2021 May 7.

Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.

Sample mislabeling or misannotation has been a long-standing problem in scientific research, particularly prevalent in large-scale, multi-omic studies due to the complexity of multi-omic workflows. There exists an urgent need for implementing quality controls to automatically screen for and correct sample mislabels or misannotations in multi-omic studies. Here, we describe a crowdsourced precisionFDA NCI-CPTAC Multi-omics Enabled Sample Mislabeling Correction Challenge, which provides a framework for systematic benchmarking and evaluation of mislabel identification and correction methods for integrative proteogenomic studies. The challenge received a large number of submissions from domestic and international data scientists, with highly variable performance observed across the submitted methods. Post-challenge collaboration between the top-performing teams and the challenge organizers has created an open-source software, COSMO, with demonstrated high accuracy and robustness in mislabeling identification and correction in simulated and real multi-omic datasets.
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http://dx.doi.org/10.1016/j.patter.2021.100245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8134945PMC
May 2021

Correction to: The effects of WeChat-based educational intervention in patients with ankylosing spondylitis: a randomized controlled trial.

Arthritis Res Ther 2021 May 25;23(1):149. Epub 2021 May 25.

West China School of Nursing/West China Hospital, Sichuan University, No. 37, Guoxuexiang, Wuhou District, Chengdu, 610041, Sichuan, China.

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http://dx.doi.org/10.1186/s13075-021-02523-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8146147PMC
May 2021

circSVIL regulates bovine myoblast development by inhibiting STAT1 phosphorylation.

Sci China Life Sci 2021 May 20. Epub 2021 May 20.

Key laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, 712100, China.

Circular RNAs (circRNAs), a novel class of non-coding RNAs with a loop structure, have recently been shown to participate in various pathophysiological processes. However, the precise role of circRNAs in myoblasts remains unclear. In this report, circSVIL was screened and identified from our previous sequencing analysis; we then performed gain- and loss-of-function experiments on bovine myoblasts by CCK8, EdU, flow cytometry, qRT-PCR, and Western blotting. The results indicate that circSVIL facilitates bovine myoblast proliferation and inhibits cell apoptosis. Using mechanism assays such as bioinformatics prediction, RNA immunoprecipitation (RIP), and cytoplasmic separation, we demonstrate that circSVIL could interact with STAT1 and inhibit STAT1 phosphorylation, thereby restraining STAT1's nuclear translocation and affecting its downstream signal cascade. Our results may elucidate a new regulatory pathway for bovine skeletal muscle development.
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http://dx.doi.org/10.1007/s11427-020-1908-2DOI Listing
May 2021

Enhanced Anti-correlation Between the Dorsal Attention and Default-mode Networks: A Resting-state fMRI Study of Acute Insomnia.

Neuroscience 2021 May 20;467:47-55. Epub 2021 May 20.

Sleep and NeuroImaging Center, Faculty of Psychology, Southwest University, Chongqing 400715, China; Key Laboratory of Cognition and Personality (Ministry of Education), Chongqing 400715, China. Electronic address:

With a greatly changed environment, sleep problem becomes a common phenomenon among college freshmen. However, this type of acute insomnia usually recovers after adapting to the circumstances, which can be defined as adaptive sleep problem (ASP). Few studies deal with this type of sleep problems. In this study, 991 first-year college freshmen were recruited on different days of the first semester to investigate their sleep status. We found that the sleep problem of college freshmen at the beginning of the semester was the most severe, compared with the other two-thirds of semester. Next, behavioral and resting-state functional magnetic imaging (rs-fMRI) data from 30 freshmen with ASP and 28 matched healthy controls (HC) were used to explore the neural basis of acute insomnia. Results showed that ASP group performed worse on many behavioral indices, such as fatigue, depression, and trait anxiety. Interestingly, students with ASP also showed significantly more negative functional connectivity between the anterior default mode network (aDMN) and the dorsal attentional network (DAN). Furthermore, a significant negative correlation was observed between Insomnia Severity Index (ISI) score and aDMN-DAN functional connectivity in the HC group, which was not observed in the case of ASP. In conclusion, the study explored the neural biomarker of adaptive sleep problem (ASP) in freshmen, and found its potentiating antagonism within the DMN-DAN. This enhanced anticorrelation may corroborate that students with ASP are in a hyperarousal state. Our current study may deepen our understanding of sleep disorders, and the enhanced anticorrelation may corroborate that ASP in due to a hyperarousal state.
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http://dx.doi.org/10.1016/j.neuroscience.2021.05.014DOI Listing
May 2021

Rcl1 depletion impairs 18S pre-rRNA processing at the A1-site and up-regulates a cohort of ribosome biogenesis genes in zebrafish.

Nucleic Acids Res 2021 06;49(10):5743-5759

MOE Key Laboratory for Molecular Animal Nutrition, College of Animal Sciences, China.

Yeast Rcl1 is a potential endonuclease that mediates pre-RNA cleavage at the A2-site to separate 18S rRNA from 5.8S and 25S rRNAs. However, the biological function of Rcl1 in opisthokonta is poorly defined. Moreover, there is no information regarding the exact positions of 18S pre-rRNA processing in zebrafish. Here, we report that zebrafish pre-rRNA harbours three major cleavage sites in the 5'ETS, namely -477nt (A'-site), -97nt (A0-site) and the 5'ETS and 18S rRNA link (A1-site), as well as two major cleavage regions within the ITS1, namely 208-218nt (site 2) and 20-33nt (site E). We also demonstrate that depletion of zebrafish Rcl1 mainly impairs cleavage at the A1-site. Phenotypically, rcl1-/- mutants exhibit a small liver and exocrine pancreas and die before 15 days post-fertilization. RNA-seq analysis revealed that the most significant event in rcl1-/- mutants is the up-regulated expression of a cohort of genes related to ribosome biogenesis and tRNA production. Our data demonstrate that Rcl1 is essential for 18S rRNA maturation at the A1-site and for digestive organogenesis in zebrafish. Rcl1 deficiency, similar to deficiencies in other ribosome biogenesis factors, might trigger a common mechanism to upregulate the expression of genes responsible for ribosome biogenesis.
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http://dx.doi.org/10.1093/nar/gkab381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8191805PMC
June 2021

[RCT of Reduction in Catheter-Related Complications by Using Intracavitary Electrocardiogram-Assisted Guidance in Neonatal PICC Placement].

Sichuan Da Xue Xue Bao Yi Xue Ban 2021 May;52(3):497-502

Department of Pediatrics, School of Medicine, University of Electronic Science and Technology of China/Sichuan Provincial People's Hospital, Sichuan Academy of Medical Sciences, Chengdu 610072, China.

Objective: To investigate the effect of intracavitary electrocardiogram (IC-ECG) guidance on peripherally inserted central catheter (PICC) related complications in neonatal patients.

Methods: A total of 210 neonatal patients were included in the study. They were admitted to the Neonatal Intensive Care Unit, Sichuan Provincial People's Hosptial between January, 2017 and December, 2019 and had PICC lines were placed in their upper limbs. The patients were randomly assigned to the observation group, which had PICC placement through conventional anatomical landmark guidance combined with IC-ECG guidance ( =105) or to the control group, which had PICC placement through only conventional anatomical landmark guidance ( =105) for PICC catheter tip positioning. Patient baseline data and data on subsequent catheter-related complications of the two groups were collected and compared.

Results: There were no significant difference between the two groups in sex composition, gestational age, postnatal days on the day of PICC placement, duration of PICC placement, disease profile, and the site of puncture ( >0.05). The observation group showed a significantly lower overall incidence of catheter-related complications (3.8%), compared to that of the control group (21.9%) ( <0.05). The observation group showed significantly lower incidence of phlebitis and arrhthmia compared to that of the control group ( <0.05).

Conclusion: A combination of anatomical landmark guidance and IC-ECG guidance to assist the placement of PICC decreases catheter-related complications.
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http://dx.doi.org/10.12182/20210560506DOI Listing
May 2021

Electrochemical Driven Phase Segregation Enabled Dual-Ion Removal Battery Deionization Electrode.

Nano Lett 2021 Jun 19;21(11):4830-4837. Epub 2021 May 19.

Shenzhen Key Laboratory of Interfacial Science and Engineering of Materials, State Environmental Protection Key Laboratory of Integrated Surface Water-Groundwater Pollution Control, Guangdong Provincial Key Laboratory of Soil and Groundwater Pollution Control, School of Environmental Science and Engineering, Southern University of Science and Technology, Shenzhen 518055, China.

Battery deionization (BDI) offers a powerful platform for integrating water treatment and energy conversion. Exploring novel BDI electrode materials with high energy storage capacity and high efficiency for both cations and anions removal is the key to advancing the BDI technique. Herein, we report the first BDI electrode material capable of simultaneously removing Cl (58.4 mg g) and Na (8.7 mg g) in water with a reversible capacity of 160 mAh g. In situ powder X-ray diffraction (PXRD) unravels that the dual-ion removal capability is attributed to a novel reversible electrochemical driven phase segregation reaction mechanism between NaBiOCl and the in situ formed metallic Bi. The unique dual-ion storage capability demonstrated with the NaBiOCl electrode indicates that exploring electrochemical reversible phase segregation electrode material holds great promise for advancing the BDI electrode for future desalination techniques and aqueous rechargeable battery systems.
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http://dx.doi.org/10.1021/acs.nanolett.1c01487DOI Listing
June 2021