Publications by authors named "Holly LaDuca"

38Publications

Paired tumor sequencing and germline testing in breast cancer management: An experience of a single academic center.

Cancer Rep (Hoboken) 2020 Sep 3:e1287. Epub 2020 Sep 3.

Department of Medicine, Division of Hematology, Oncology, and Stem Cell Transplant Medicine, Rush University Medical Center, Chicago, IL, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cnr2.1287DOI Listing
September 2020

Rare Germline Pathogenic Mutations of DNA Repair Genes Are Most Strongly Associated with Grade Group 5 Prostate Cancer.

Eur Urol Oncol 2020 04 14;3(2):224-230. Epub 2020 Jan 14.

Department of Urology and the James Buchanan Brady Urologic Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.euo.2019.12.003DOI Listing
April 2020

Cancer Risks Associated With Germline Pathogenic Variants: An International Study of 524 Families.

Authors:
Xin Yang Goska Leslie Alicja Doroszuk Sandra Schneider Jamie Allen Brennan Decker Alison M Dunning James Redman James Scarth Inga Plaskocinska Craig Luccarini Mitul Shah Karen Pooley Leila Dorling Andrew Lee Muriel A Adank Julian Adlard Kristiina Aittomäki Irene L Andrulis Peter Ang Julian Barwell Jonine L Bernstein Kristie Bobolis Åke Borg Carl Blomqvist Kathleen B M Claes Patrick Concannon Adeline Cuggia Julie O Culver Francesca Damiola Antoine de Pauw Orland Diez Jill S Dolinsky Susan M Domchek Christoph Engel D Gareth Evans Florentia Fostira Judy Garber Lisa Golmard Ellen L Goode Stephen B Gruber Eric Hahnen Christopher Hake Tuomas Heikkinen Judith E Hurley Ramunas Janavicius Zdenek Kleibl Petra Kleiblova Irene Konstantopoulou Anders Kvist Holly Laduca Ann S G Lee Fabienne Lesueur Eamonn R Maher Arto Mannermaa Siranoush Manoukian Rachel McFarland Wendy McKinnon Alfons Meindl Kelly Metcalfe Nur Aishah Mohd Taib Jukka Moilanen Katherine L Nathanson Susan Neuhausen Pei Sze Ng Tu Nguyen-Dumont Sarah M Nielsen Florian Obermair Kenneth Offit Olufunmilayo I Olopade Laura Ottini Judith Penkert Katri Pylkäs Paolo Radice Susan J Ramus Vilius Rudaitis Lucy Side Rachel Silva-Smith Valentina Silvestri Anne-Bine Skytte Thomas Slavin Jana Soukupova Carlo Tondini Alison H Trainer Gary Unzeitig Lydia Usha Thomas van Overeem Hansen James Whitworth Marie Wood Cheng Har Yip Sook-Yee Yoon Amal Yussuf George Zogopoulos David Goldgar John L Hopper Georgia Chenevix-Trench Paul Pharoah Sophia H L George Judith Balmaña Claude Houdayer Paul James Zaki El-Haffaf Hans Ehrencrona Marketa Janatova Paolo Peterlongo Heli Nevanlinna Rita Schmutzler Soo-Hwang Teo Mark Robson Tuya Pal Fergus Couch Jeffrey N Weitzel Aaron Elliott Melissa Southey Robert Winqvist Douglas F Easton William D Foulkes Antonis C Antoniou Marc Tischkowitz

J Clin Oncol 2020 Mar 16;38(7):674-685. Epub 2019 Dec 16.

Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, and Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1200/JCO.19.01907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049229PMC
March 2020

Tumour characteristics provide evidence for germline mismatch repair missense variant pathogenicity.

J Med Genet 2020 Jan 7;57(1):62-69. Epub 2019 Aug 7.

Bioinformatics, Ambry Genetics Corp, Aliso Viejo, California, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/jmedgenet-2019-106096DOI Listing
January 2020

Clinical features and cancer risk in families with pathogenic variants irrespective of clinical criteria.

J Med Genet 2019 12 11;56(12):838-843. Epub 2019 Jul 11.

Medicine, Yale University School of Medicine, New Haven, Connecticut, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/jmedgenet-2019-105991DOI Listing
December 2019

Genotype-phenotype associations among panel-based TP53+ subjects.

Genet Med 2019 11 20;21(11):2478-2484. Epub 2019 May 20.

Department of Medical Oncology, Division of Population Sciences, Dana-Farber Cancer Institute, Boston, MA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41436-019-0541-yDOI Listing
November 2019

Quality of Clinician-Reported Cancer History When Ordering Genetic Testing.

JCO Clin Cancer Inform 2018 12;2:1-11

Holly LaDuca, Stephanie Gutierrez, Amal Yussuf, Nadia Ho, Jonathan Pepper, Patrick Reineke, Kirsten Blanco, Carolyn Horton, Jill S. Dolinsky, Ambry Genetics, Aliso Viejo; Rachel McFarland, University of California Irvine, Irvine, CA; and Taylor Cain, Sarah Lawrence College, Bronxville, NY.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1200/CCI.18.00014DOI Listing
December 2018

Differences in TP53 Mutation Carrier Phenotypes Emerge From Panel-Based Testing.

J Natl Cancer Inst 2018 08;110(8):863-870

Division of Population Sciences, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jnci/djy001DOI Listing
August 2018

Frequency of mutations in a large series of clinically ascertained ovarian cancer cases tested on multi-gene panels compared to reference controls.

Gynecol Oncol 2017 11 7;147(2):375-380. Epub 2017 Sep 7.

Huntsman Cancer Institute, Department of Dermatology, University of Utah School of Medicine, Salt Lake City, UT, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ygyno.2017.08.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801741PMC
November 2017

Advances in the diagnosis of hereditary kidney cancer: Initial results of a multigene panel test.

Cancer 2017 Nov 8;123(22):4363-4371. Epub 2017 Aug 8.

Department of Urology, Yale School of Medicine, New Haven, Connecticut.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cncr.30893DOI Listing
November 2017

Multigene Panel Testing Provides a New Perspective on Lynch Syndrome.

J Clin Oncol 2017 Aug 17;35(22):2568-2575. Epub 2017 May 17.

Carin R. Espenschied, Holly LaDuca, Shuwei Li, Rachel McFarland, and Chia-Ling Gau, Ambry Genetics, Clinical Diagnostics, Aliso Viejo, CA; and Heather Hampel, The Ohio State University Comprehensive Cancer Center, Columbus, OH.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1200/JCO.2016.71.9260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186580PMC
August 2017

Exome sequencing covers >98% of mutations identified on targeted next generation sequencing panels.

PLoS One 2017 2;12(2):e0170843. Epub 2017 Feb 2.

Department of Pediatrics, Division of Genetics and Genomic Medicine, University of California Irvine, Irvine, California, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0170843PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289469PMC
August 2017

Breast cancer risk is similar for CHEK2 founder and non-founder mutation carriers.

Cancer Genet 2016 09 15;209(9):403-407. Epub 2016 Aug 15.

Department of Clinical Diagnostics, Ambry Genetics, 15 Argonaut, Aliso Viejo, CA 92656, USA; Department of Pediatrics, Division of Genetics and Genomic Medicine, University of California, 2054 E. Hewitt Hall, Irvine, CA 92697, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cancergen.2016.08.005DOI Listing
September 2016

Utilization of multigene panels in hereditary cancer predisposition testing: analysis of more than 2,000 patients.

Genet Med 2014 Nov 24;16(11):830-7. Epub 2014 Apr 24.

1] Department of Clinical Diagnostics, Ambry Genetics, Aliso Viejo, California, USA [2] Division of Genetics and Metabolism, Department of Pediatrics, University of California-Irvine, Irvine, California, USA.

View Article

Download full-text PDF

Source
http://www.ambrygen.com/sites/default/files/LaDuca%20et%20al
Web Search
http://www.nature.com/doifinder/10.1038/gim.2014.40
Publisher Site
http://dx.doi.org/10.1038/gim.2014.40DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4225457PMC
November 2014

Sapropterin therapy increases stability of blood phenylalanine levels in patients with BH4-responsive phenylketonuria (PKU).

Mol Genet Metab 2010 Oct-Nov;101(2-3):110-4. Epub 2010 Jun 27.

Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL 60614, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ymgme.2010.06.015DOI Listing
January 2011