Holger Moch

Holger Moch

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Holger Moch

Holger Moch

Publications by authors named "Holger Moch"

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100Publications

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Cancer of unknown primary-Epidemiological trends and relevance of comprehensive genomic profiling.

Cancer Med 2018 Sep 17;7(9):4814-4824. Epub 2018 Jul 17.

Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland.

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September 2018

Fluorocholine Transport Mediated by the Organic Cation Transporter 2 (OCT2, SLC22A2): Implication for Imaging of Kidney Tumors.

Drug Metab Dispos 2018 08 24;46(8):1129-1136. Epub 2018 May 24.

Departments of Clinical Pharmacology and Toxicology (M.V., A.T., Z.G., S.H., C.L., C.H., G.A.K.-U.) and Pathology and Molecular Pathology (P.H.S., H.M.), University Hospital Zurich, University of Zurich, Zurich, Switzerland; and Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China (C.L.).

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August 2018

Advancing synoptic cancer reports beyond English: the University of Bern/PathoLink approach.

Virchows Arch 2018 Aug 7. Epub 2018 Aug 7.

Institute of Pathology, University of Bern, Murtenstrasse 31, 3008, Bern, Switzerland.

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August 2018

Human Streptococcal Necrotizing Fasciitis Histopathology Mirrored in a Murine Model.

Am J Pathol 2018 Jul 22;188(7):1517-1523. Epub 2018 Apr 22.

Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland. Electronic address:

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July 2018

Multi-laboratory proficiency testing of clinical cancer genomic profiling by next-generation sequencing.

Pathol Res Pract 2018 Jul 22;214(7):957-963. Epub 2018 May 22.

Department of Pathology and Molecular Pathology, University Hospital Zurich, 8091, Zurich, Switzerland; Senckenberg Institute of Pathology, University Hospital Frankfurt, 60590, Frankfurt, Germany. Electronic address:

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July 2018

The expression of the cancer testis antigen MAGE A4: A favorable prognostic biomarker in salivary gland carcinomas related to low tumor grading.

Laryngoscope Investig Otolaryngol 2018 Jun 19;3(3):182-190. Epub 2018 Apr 19.

Department of Otorhinolaryngology, Head and Neck Surgery Kantonsspital St. Gallen St. Gallen Switzerland.

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June 2018

Somatic BRCA1 mutations in clinically sporadic breast cancer with medullary histological features.

J Cancer Res Clin Oncol 2018 May 17;144(5):865-874. Epub 2018 Feb 17.

Department of Pathology and Molecular Pathology, University Hospital Zurich, 8091, Zurich, Switzerland.

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May 2018

Morphological clues to the appropriate recognition of hereditary renal neoplasms.

Semin Diagn Pathol 2018 May 14;35(3):184-192. Epub 2018 Feb 14.

Department of Pathology and Laboratory Medicine, University of Tennessee Health Sciences, Memphis, USA; Department of Urology, University of Tennessee Health Sciences, Memphis, USA.

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May 2018

Two in One: Epithelioid angiomyolipoma within a classic kidney angiomyolipoma - a case report.

BMC Nephrol 2018 May 30;19(1):123. Epub 2018 May 30.

Ultrasound Learning Center EFSUMB, Klinik Hirslanden, Zürich, Switzerland.

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May 2018

Comprehensive immunohistochemical analysis of PD-L1 shows scarce expression in castration-resistant prostate cancer.

Oncotarget 2018 Feb 4;9(12):10284-10293. Epub 2017 Dec 4.

Department of Pathology and Molecular Pathology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

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February 2018

SOX2 Gene Amplification and Overexpression is Linked to HPV-positive Vulvar Carcinomas.

Int J Gynecol Pathol 2018 Jan;37(1):68-73

Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland.

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January 2018

Biomarker discovery for renal cancer stem cells.

J Pathol Clin Res 2018 Jan 17;4(1):3-18. Epub 2018 Jan 17.

Department of Pathology and Molecular PathologyUniversity Hospital ZurichSwitzerland.

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January 2018

Computed Tomography Radiomics Predicts HPV Status and Local Tumor Control After Definitive Radiochemotherapy in Head and Neck Squamous Cell Carcinoma.

Int J Radiat Oncol Biol Phys 2017 11 15;99(4):921-928. Epub 2017 Jun 15.

Department of Radiation Oncology, University Hospital Zurich and University of Zurich, Zurich, Switzerland.

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November 2017

Mirna Expression in Bladder Cancer and Their Potential Role in Clinical Practice.

Curr Drug Metab 2017 Oct;18(8):712-722

Department of Pathology, Unit of Anatomical Pathology, Department of Surgery, Faculty of Medicine, Cordoba. Spain.

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October 2017

Targeting the Programmed Cell Death-1 Pathway in Genitourinary Tumors: Current Progress and Future Perspectives.

Curr Drug Metab 2017 Oct;18(8):700-711

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, 350 West 11th Street, IUHPL Room 4010, Indianapolis, IN 46202. United States.

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October 2017

Urinary Biomarkers for Prostate Cancer.

Curr Drug Metab 2017 Oct;18(8):723-726

Addarii Institute of Oncology, Viale Ercolani 4/2, 40138, Bologna. Italy.

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October 2017

The presence of aberrant p53 pattern is a negative prognostic predictor in squamous cell carcinoma of the nasal vestibule.

Eur Arch Otorhinolaryngol 2017 Sep 1;274(9):3503-3512. Epub 2017 Jul 1.

Department of Pathology and Molecular Pathology, Zurich University Hospital and University of Zurich, Raemistrasse 100, 8091, Zurich, Switzerland.

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September 2017

Neue und vielversprechende molekulare Therapieoptionen in verschiedenen Subtypen des Nierenzellkarzinoms.

Ther Umsch 2017 Sep;74(4):171-179

1 Institut für Pathologie und Molekularpathologie, UniversitätsSpital Zürich, Zürich.

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September 2017

Discretization of Gene Expression Data Unmasks Molecular Subgroups Recurring in Different Human Cancer Types.

PLoS One 2016 18;11(8):e0161514. Epub 2016 Aug 18.

Institute of Surgical Pathology, University Hospital Zurich, Schmelzbergstrasse 12, 8091 Zurich, Switzerland.

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July 2017

p16 : A surrogate marker of high-risk human papillomavirus infection in squamous cell carcinoma of the nasal vestibule.

Head Neck 2017 07 28;39(7):1392-1398. Epub 2017 Mar 28.

Department of Pathology and Molecular Pathology, Zurich University Hospital and University of Zurich, Schmelzbergstrasse 12, CH-8091, Zurich, Switzerland.

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July 2017

Diagnostic criteria for oncocytic renal neoplasms: a survey of urologic pathologists.

Hum Pathol 2017 05 14;63:149-156. Epub 2017 Mar 14.

Department of Pathology and Laboratory Medicine, Detroit, MI, 48202, United States; Henry Ford Cancer Institute, Henry Ford Health System, Detroit, MI, 48202, United States.

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May 2017

Prominent Oncogenic Roles of EVI1 in Breast Carcinoma.

Cancer Res 2017 04 16;77(8):2148-2160. Epub 2017 Feb 16.

Department of Biomedicine, University of Basel and University Hospital Basel, Basel, Switzerland.

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April 2017

Detecting circulating tumor DNA in renal cancer: An open challenge.

Exp Mol Pathol 2017 04 23;102(2):255-261. Epub 2017 Feb 23.

Institute of Surgical Pathology, University Hospital Zurich, Switzerland. Electronic address:

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April 2017

Value of postmortem studies in deceased neonatal and pediatric intensive care unit patients.

Virchows Arch 2017 Feb 14;470(2):217-223. Epub 2016 Dec 14.

Department of Pathology and Molecular Pathology, University Hospital Zurich, Schmelzbergstrasse 12, 8091, Zurich, Switzerland.

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February 2017

Detailed simulation of cancer exome sequencing data reveals differences and common limitations of variant callers.

BMC Bioinformatics 2017 Jan 3;18(1). Epub 2017 Jan 3.

Department of Biosystems Science and Engineering, ETH Zurich, Mattenstr, Basel, 26, 4058, Switzerland.

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January 2017

Lack of MRE11-RAD50-NBS1 (MRN) complex detection occurs frequently in low-grade epithelial ovarian cancer.

BMC Cancer 2017 01 10;17(1):44. Epub 2017 Jan 10.

Department of Gynecology, University Hospital Zurich, CH- 8091, Zurich, Switzerland.

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January 2017

Emerging Immunotargets in Metastatic Renal Cell Carcinoma.

Curr Drug Targets 2016 ;17(7):771-6

Gayle and Tom Benson Cancer Center, Ochsner Medical Center, 1514 Jefferson Highway, New Orleans, Louisiana 70121, USA.

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December 2016

An Overview of Emerging Immunotargets of Genitourinary Tumors.

Curr Drug Targets 2016 ;17(7):750-6

Medical Oncology, Azienda Ospedaliera Universitaria Integrata, University of Verona, Piazzale L.A. Scuro 10, 37124 Verona, Italy.

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December 2016

Emerging Immunotargets in Bladder Cancer.

Curr Drug Targets 2016 ;17(7):757-70

Medical Oncology, Azienda Ospedaliera Universitaria Integrata, University of Verona, Piazzale L.A. Scuro 10, 37124 Verona, Italy.

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December 2016

Emerging Immunotargets and Immunotherapies in Prostate Cancer.

Curr Drug Targets 2016 ;17(7):777-82

Medical Oncology, Azienda Ospedaliera Universitaria Integrata, University of Verona, Piazzale L.A. Scuro 10, 37124 Verona, Italy.

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December 2016

The Microphthalmia-Associated Transcription Factor p.E318K Mutation Does Not Play a Major Role in Sporadic Renal Cell Tumors from Caucasian Patients.

Pathobiology 2016 22;83(4):165-9. Epub 2016 Mar 22.

Institute of Pathology, University Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany.

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December 2016

Clinical impact of prostate biopsy undergrading in an academic and community setting.

World J Urol 2016 Oct 1;34(10):1481-90. Epub 2016 Mar 1.

Department of Urology, University Hospital Zurich, University of Zurich, Frauenklinikstr.10, 8091, Zurich, Switzerland.

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October 2016

Interleukin-33 Expression Indicates a Favorable Prognosis in Malignant Salivary Gland Tumors.

Int J Surg Pathol 2016 Aug 23;24(5):394-400. Epub 2016 Feb 23.

Institute of Pathology, Cantonal Hospital Baselland, Liestal, Switzerland

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August 2016

The Value of In Vitro Diagnostic Testing in Medical Practice: A Status Report.

PLoS One 2016 4;11(3):e0149856. Epub 2016 Mar 4.

Divisional Medical and Scientific Affairs, F. Hoffmann-La Roche Ltd, 4070, Basel, Switzerland.

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August 2016

The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours.

Eur Urol 2016 07 28;70(1):93-105. Epub 2016 Feb 28.

Department of Pathology and Laboratory Medicine, Indiana University Health Partners, Indiana University School of Medicine, Indianapolis, IN, USA.

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July 2016

PD-L1 expression is regulated by hypoxia inducible factor in clear cell renal cell carcinoma.

Int J Cancer 2016 07 25;139(2):396-403. Epub 2016 Mar 25.

Institute of Surgical Pathology, University Hospital Zurich, Switzerland.

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July 2016

The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part B: Prostate and Bladder Tumours.

Eur Urol 2016 07 17;70(1):106-119. Epub 2016 Mar 17.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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July 2016

Interleukin-33 in human gliomas: Expression and prognostic significance.

Oncol Lett 2016 Jul 25;12(1):445-452. Epub 2016 May 25.

Institute of Pathology Liestal, Cantonal Hospital Baselland, 4410 Liestal, Switzerland; Department of Pathology, Institute of Surgical Pathology, University Hospital Zurich, 8091 Zurich, Switzerland.

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July 2016

Similar lymphocytic infiltration pattern in primary breast cancer and their corresponding distant metastases.

Oncoimmunology 2016 Jun 5;5(6):e1153208. Epub 2016 May 5.

Institute of Surgical Pathology, University Hospital Zurich, Schmelzbergstrasse , Zurich, Switzerland.

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June 2016

L1-CAM is commonly expressed in testicular germ cell tumours.

J Clin Pathol 2016 May 1;69(5):460-2. Epub 2016 Mar 1.

Institute of Surgical Pathology, University Hospital of Zurich, University of Zurich, Zurich, Switzerland.

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May 2016

Hypoxia, Hypoxia-inducible Transcription Factors, and Renal Cancer.

Eur Urol 2016 Apr 19;69(4):646-657. Epub 2015 Aug 19.

Henry Wellcome Building for Molecular Physiology, University of Oxford, Oxford, UK.

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April 2016

Interaction of tumor cells with infiltrating lymphocytes via CD70 and CD27 in clear cell renal cell carcinoma.

Oncoimmunology 2015 Dec 29;4(12):e1049805. Epub 2015 May 29.

Institute of Surgical Pathology; University Hospital Zürich ; Zürich, Switzerland.

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December 2015

Morphologic and molecular backgrounds for personalized management of genito-urinary cancers: an overview.

Curr Drug Targets 2015 ;16(2):96-102

Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Via Conca 71, I-60126 Torrette, Ancona, Italy.

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October 2015

Molecular foundations for personalized therapy in prostate cancer.

Curr Drug Targets 2015 ;16(2):103-14

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, 350 West 11th Street, IUHPL Room 4010, Indianapolis, IN 46202, USA.

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October 2015

Oncotargets in different renal cancer subtypes.

Curr Drug Targets 2015 ;16(2):125-35

Institute of Surgical Pathology, University of Zurich, Zurich, Switzerland.

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October 2015

Bladder cancer: molecular determinants of personalized therapy.

Curr Drug Targets 2015 ;16(2):115-24

Department of Surgery and Pathology, Cordoba University Medical School, Cordoba, Spain and Champalimaud Clinical Center, Lisbon, Portugal.

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October 2015

Diagnostic Accuracy of Quantitative and Qualitative Phase-Contrast Imaging for the ex Vivo Characterization of Human Coronary Atherosclerotic Plaques.

Radiology 2015 Oct 5;277(1):64-72. Epub 2015 May 5.

From the Institute of Diagnostic and Interventional Radiology (S.W., F.M., M.v.W., H.A., P.S.) and Institute of Pathology (V.T., L.B., H.M.), University Hospital Zurich, Raemistrasse 100, 8091 Zurich, Switzerland; Department of Forensic Medicine and Radiology, Institute of Forensic Medicine, University of Zurich, Zurich, Switzerland (S.W., S.B., M.T., P.S.); Swiss Light Source, Paul Scherrer Institute, Villigen, Switzerland (S.P., P.M., M.S.); and Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland (S.P., M.S.).

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October 2015

Surfaceome of classical Hodgkin and non-Hodgkin lymphoma.

Proteomics Clin Appl 2015 Aug;9(7-8):661-70

Department of Biology, Institute of Molecular Systems Biology, Swiss Federal Institute of Technology (ETH) Zurich, Zurich, Switzerland.

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August 2015

Clear cell papillary renal cell carcinoma and renal angiomyoadenomatous tumor: two variants of a morphologic, immunohistochemical, and genetic distinct entity of renal cell carcinoma.

Am J Surg Pathol 2015 Jul;39(7):889-901

*Institute of Surgical Pathology, University Hospital Zurich, Zurich ‡‡Cantonal Hospital Aarau §§Institute of Histological and Cytological Diagnostics, Aarau ¶¶University Institute of Pathology, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland †Institute of Pathology, University Medicine Göttingen (UMG), Göttingen ∥Institute of Pathology, University Hospital Tübingen, Tübingen ¶Institute of Pathology, HELIOS Hospital Berlin-Buch, Berlin #Institute of Pathology Bogenhausen, Städtisches Klinikum München GmbH, Munich **Institute of Pathology, Heinrich Heine University Hospital, Dusseldorf ††Institute of Pathology, RWTH University, Aachen ∥∥Institute of Pathology, HELIOS Hospital Schwerin, Schwerin ***Institute of Pathology, Städtisches Klinikum Karlsruhe gGmbH, Karlsruhe †††Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany ‡Service d'Anatomie et Cytologie Pathologiques 1, Groupe Hospitalier Pitié-Salpêtrière, Paris, France §Department of Medicine, Renal Division, Brigham and Women's Hospital, Boston, MA ##Institute of Pathology, University of Florence, Florence, Italy.

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July 2015

A clearer view of the molecular complexity of clear cell renal cell carcinoma.

Annu Rev Pathol 2015 27;10:263-89. Epub 2014 Oct 27.

Institute of Physiology and Zurich Center for Integrative Human Physiology, University of Zurich, Zurich CH-8057, Switzerland; email:

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June 2015

Changes in autopsy rates among cancer patients and their impact on cancer statistics from a public health point of view: a longitudinal study from 1980 to 2010 with data from Cancer Registry Zurich.

Virchows Arch 2015 Jun 7;466(6):637-43. Epub 2015 Mar 7.

Division of Chronic Disease Epidemiology, Epidemiology, Biostatistics and Prevention Institute (EPBI), University of Zurich, Hirschengraben 84, 8001, Zürich, Switzerland.

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June 2015

Tall cell papillary thyroid carcinoma: new diagnostic criteria and mutations in BRAF and TERT.

Endocr Relat Cancer 2015 Jun 13;22(3):419-29. Epub 2015 Apr 13.

Institute of PathologyUniversity of Bern, Murtenstrasse 31, 3010 Bern, SwitzerlandDivision of Nuclear MedicineUniversity Hospital Zurich, Zurich, SwitzerlandDepartment of NeuropathologyInstitute of Pathology, German Cancer Research Center (DKFZ), Ruprecht-Karls University, and Clinical Cooperation Unit Neuropathology, Heidelberg, GermanyInstitute of Surgical PathologyUniversity Hospital Zurich, Zurich, SwitzerlandInstitute of Surgical PathologyTriemlispital, Zürich, Switzerland.

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June 2015

CD10 expression in 325 testicular germ cell tumours.

J Clin Pathol 2015 May 23;68(5):400-3. Epub 2015 Feb 23.

Institute of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland.

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May 2015

MAGI3-AKT3 fusion in breast cancer amended.

Nature 2015 Apr;520(7547):E11-2

Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York 10065, USA.

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April 2015

Insulin-like growth factor I is expressed in classical and nodular lymphocyte-predominant Hodgkin's lymphoma tumour and microenvironmental cells.

Cell Tissue Res 2015 Mar 9;359(3):841-51. Epub 2014 Dec 9.

Research Group Neuro-endocrine-immune Interactions, Institute of Anatomy, University of Zurich, Zurich, Switzerland,

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March 2015

Fullerenols and glucosamine fullerenes reduce infarct volume and cerebral inflammation after ischemic stroke in normotensive and hypertensive rats.

Exp Neurol 2015 Mar 24;265:142-51. Epub 2015 Jan 24.

Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, 14476 Potsdam, Germany; Institute for Chemistry and Biology, Freie Universität Berlin, 14195 Berlin, Germany.

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March 2015

Functional characterization of BC039389-GATM and KLK4-KRSP1 chimeric read-through transcripts which are up-regulated in renal cell cancer.

BMC Genomics 2015 Mar 27;16:247. Epub 2015 Mar 27.

Institute of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland.

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March 2015

Characterization of the 19q12 amplification including CCNE1 and URI in different epithelial ovarian cancer subtypes.

Exp Mol Pathol 2015 Feb 16;98(1):47-54. Epub 2014 Dec 16.

Institute of Surgical Pathology, University Hospital Zurich, Schmelzbergstr. 12, CH-8091 Zurich, Switzerland.

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February 2015

Multicenter immunohistochemical ALK-testing of non-small-cell lung cancer shows high concordance after harmonization of techniques and interpretation criteria.

J Thorac Oncol 2014 Nov;9(11):1685-92

*Institute of Pathology, Charité BERLIN, Berlin, Germany; †Institute of Pathology, University of Heidelberg, Heidelberg, Germany; ‡Department of Pathology, Aberdeen University Medical School, Aberdeen, United Kingdom; §Department of Pathology and Cytology, Karolinska University Hospital, Solna, Stockholm, Sweden; ‖Department of Pathology, University Hospital Cologne, Cologne, Germany; ¶Laboratorio de Dianas Terapeuticas, Hospital Universitario Sanchinarro, Madrid, Spain; #Institute of Pathology, Klinikum Großhadern Ludwig-Maximilians-Universität, Munich, Germany; **Institute of Pathology, UZ ANTWERPEN, Edegem, Belgium; ††Institute of Pathology, Klinikum rechts der Isar, TU, Munich, Germany; ‡‡Institute of Pathology, University Hospital Carl Gustav Carus, Dresden, Germany; §§Institute of Pathology, Universitätsspital Basel, Basel, Germany; ‖‖Institute of Pathology, HSK Dr.-Horst-Schmidt-Kliniken GmbH, Wiesbaden, Germany; ¶¶Institute of Pathology, Universitäts Spital Zürich, Zurich, Switzerland; ##Institute of Pathology, Centre Jean Perrin, Clermont-Ferrand, France; ***Patologisk Institut, Århus Universitetshospital, Århus, Denmark; †††Pathology-Berlin, Bioptisches Institut Gemeinschaftspraxis für Pathologie, Berlin, Germany.

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November 2014

Hif-2α promotes degradation of mammalian peroxisomes by selective autophagy.

Cell Metab 2014 Nov 4;20(5):882-897. Epub 2014 Nov 4.

Institute of Molecular Health Sciences, ETH Zurich, CH-8093 Zurich, Switzerland; Competence Center for Systems Physiology and Metabolic Diseases, ETH Zurich, CH-8093 Zurich, Switzerland. Electronic address:

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November 2014