Holger Kramer

Holger Kramer

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Holger Kramer

Holger Kramer

Publications by authors named "Holger Kramer"

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Sugar-Induced Obesity and Insulin Resistance Are Uncoupled from Shortened Survival in Drosophila.

Cell Metab 2020 Mar 16. Epub 2020 Mar 16.

MRC London Institute of Medical Sciences, Du Cane Road, London W12 0NN, UK; Institute of Clinical Sciences, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2020.02.016DOI Listing
March 2020

TRF1 averts chromatin remodelling, recombination and replication dependent-break induced replication at mouse telomeres.

Elife 2020 Jan 14;9. Epub 2020 Jan 14.

Telomere Replication and Stability group, Medical Research Council - London Institute of Medical Sciences, London, United Kingdom.

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http://dx.doi.org/10.7554/eLife.49817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986873PMC
January 2020

PP4 phosphatase cooperates in recombinational DNA repair by enhancing double-strand break end resection.

Nucleic Acids Res 2019 Nov;47(20):10706-10727

Cell Cycle and Genome Stability Group, Institute of Functional Biology and Genomics (IBFG), Spanish National Research Council (CSIC). University of Salamanca (USAL), C/ Zacarías González 2, Salamanca 37007, Spain.

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http://dx.doi.org/10.1093/nar/gkz794DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6846210PMC
November 2019

A conserved ATP- and Scc2/4-dependent activity for cohesin in tethering DNA molecules.

Sci Adv 2019 11 27;5(11):eaay6804. Epub 2019 Nov 27.

Cell Cycle Group, Medical Research Council London Institute of Medical Sciences, Du Cane Road, London W12 0NN, UK.

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http://dx.doi.org/10.1126/sciadv.aay6804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881171PMC
November 2019

Single nucleotide polymorphisms in Orai1 associated with atopic dermatitis inhibit protein turnover, decrease calcium entry and disrupt calcium-dependent gene expression.

Hum Mol Genet 2019 Oct 10. Epub 2019 Oct 10.

Department of Physiology, Anatomy and Genetics, Parks Road, Oxford, OX1 3PT United Kingdom.

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http://dx.doi.org/10.1093/hmg/ddz223DOI Listing
October 2019

Use of Modified Enterotoxin Fragments for Claudin Targeting in Liver and Skin Cells.

Int J Mol Sci 2019 Sep 26;20(19). Epub 2019 Sep 26.

Charité-Universitätsmedizin Berlin, Institute of Clinical Physiology, Hindenburgdamm 30, 12203 Berlin, Germany.

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http://dx.doi.org/10.3390/ijms20194774DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801472PMC
September 2019

Sex Differences in Intestinal Carbohydrate Metabolism Promote Food Intake and Sperm Maturation.

Cell 2019 Aug;178(4):901-918.e16

MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.07.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700282PMC
August 2019

Binding of sulphonylureas to plasma proteins - A KATP channel perspective.

PLoS One 2018 17;13(5):e0197634. Epub 2018 May 17.

Oxford Centre for Gene Function, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0197634PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5957440PMC
December 2018

Critical Role of the UBL Domain in Stimulating the E3 Ubiquitin Ligase Activity of UHRF1 toward Chromatin.

Mol Cell 2018 11 1;72(4):739-752.e9. Epub 2018 Nov 1.

Institute of Functional Epigenetics, Helmholtz Zentrum München, 85764 Neuherberg, Germany; MRC London Institute of Medical Sciences (LMS), Du Cane Road, London W12 0NN, UK; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London W12 0NN, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10972765183079
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http://dx.doi.org/10.1016/j.molcel.2018.09.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242706PMC
November 2018

The Allergen Der p3 from House Dust Mite Stimulates Store-Operated Ca Channels and Mast Cell Migration through PAR4 Receptors.

Mol Cell 2018 04;70(2):228-241.e5

Department of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford OX1 3PT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2018.03.025DOI Listing
April 2018

Proteomics Analysis of Ovarian Cancer Cell Lines and Tissues Reveals Drug Resistance-associated Proteins.

Cancer Genomics Proteomics 2017 01;14(1):35-51

Department of Pharmaceutical & Biological Chemistry, UCL School of Pharmacy, London, U.K.

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http://dx.doi.org/10.21873/cgp.20017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5267499PMC
January 2017

Systemic Administration of Glibenclamide Fails to Achieve Therapeutic Levels in the Brain and Cerebrospinal Fluid of Rodents.

PLoS One 2015 30;10(7):e0134476. Epub 2015 Jul 30.

Department of Physiology, Anatomy and Genetics and OXION, University of Oxford, Oxford, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0134476PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520580PMC
May 2016

Kinetic Investigations of the Role of Factor Inhibiting Hypoxia-inducible Factor (FIH) as an Oxygen Sensor.

J Biol Chem 2015 Aug 25;290(32):19726-42. Epub 2015 Jun 25.

From the Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, United Kingdom and

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http://dx.doi.org/10.1074/jbc.M115.653014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528135PMC
August 2015

Antibodies to GABAA receptor α1 and γ2 subunits: clinical and serologic characterization.

Neurology 2015 Mar 30;84(12):1233-41. Epub 2015 Jan 30.

From the Nuffield Department of Clinical Neurosciences (P.P., R.P., S.M., A.N., S.R.I., C.B., D.B., B.L., P.W., A.V.) and the Department of Physiology, Anatomy and Genetics (H.B.K.), University of Oxford; St George's Healthcare NHS Trust (J.A.C.), Tooting, London; the Centre for Neuroscience & Trauma, Blizard Institute (A.M.), Barts and The London School of Medicine and Dentistry, Queen Mary University of London; and The Walton Centre Foundation Trust (A.J.), Liverpool, UK.

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http://dx.doi.org/10.1212/WNL.0000000000001326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366091PMC
March 2015

Changes in gene expression associated with FTO overexpression in mice.

PLoS One 2014 19;9(5):e97162. Epub 2014 May 19.

Henry Wellcome Centre for Gene Function, Department of Physiology, Anatomy; and Genetics, University of Oxford, Parks Road, Oxford, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0097162PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026227PMC
December 2014

Dynamic assembly of a membrane signaling complex enables selective activation of NFAT by Orai1.

Curr Biol 2014 Jun 5;24(12):1361-1368. Epub 2014 Jun 5.

Department of Physiology, Anatomy, and Genetics, Oxford University, Parks Road, Oxford OX1 3PT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2014.04.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062936PMC
June 2014

Deubiquitinating enzyme specificity for ubiquitin chain topology profiled by di-ubiquitin activity probes.

Chem Biol 2013 Dec 27;20(12):1447-55. Epub 2013 Nov 27.

Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7FZ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2013.10.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899023PMC
December 2013

Glycomimetic affinity-enrichment proteomics identifies partners for a clinically-utilized iminosugar.

Chem Sci 2013 Sep 8;4(9):3442-3446. Epub 2013 Jul 8.

Department of Chemistry, Chemistry Research Laboratory, Oxford University, Mansfield Road, Oxford, OX1 3TA, UK.

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http://dx.doi.org/10.1039/C3SC50826ADOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485602PMC
September 2013

HIV-1 infection-induced apoptotic microparticles inhibit human DCs via CD44.

J Clin Invest 2012 Dec 19;122(12):4685-97. Epub 2012 Nov 19.

New York University Langone Medical Center, New York, New York 10016, USA.

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http://dx.doi.org/10.1172/JCI64439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533550PMC
December 2012

Detection of ubiquitin-proteasome enzymatic activities in cells: application of activity-based probes to inhibitor development.

Biochim Biophys Acta 2012 Nov 19;1823(11):2029-37. Epub 2012 May 19.

Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford OX1 3QX, UK.

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http://dx.doi.org/10.1016/j.bbamcr.2012.05.014DOI Listing
November 2012

Fluorescence-based active site probes for profiling deubiquitinating enzymes.

Org Biomol Chem 2012 May 28;10(17):3379-83. Epub 2012 Mar 28.

Nuffield Department of Medicine, University of Oxford, Henry Welcome Building for Molecular Physiology, Roosevelt Drive, Oxford, OX3 7BN, UK.

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http://dx.doi.org/10.1039/c2ob25258aDOI Listing
May 2012

Label-free quantitative proteomics reveals regulation of interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) and 5'-3'-exoribonuclease 2 (XRN2) during respiratory syncytial virus infection.

Virol J 2011 Sep 20;8(1):442. Epub 2011 Sep 20.

Henry Wellcome Building for Molecular Physiology, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK.

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http://dx.doi.org/10.1186/1743-422X-8-442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3190389PMC
September 2011

Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1).

J Mol Biol 2011 Jul 13;410(2):268-79. Epub 2011 May 13.

Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK.

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http://dx.doi.org/10.1016/j.jmb.2011.04.075DOI Listing
July 2011

Differential sensitivity of hypoxia inducible factor hydroxylation sites to hypoxia and hydroxylase inhibitors.

J Biol Chem 2011 Apr 18;286(15):13041-51. Epub 2011 Feb 18.

Nuffield Department of Clinical Medicine, Henry Wellcome Building for Molecular Physiology, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M110.211110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075650PMC
April 2011

Small-molecule-based inhibition of histone demethylation in cells assessed by quantitative mass spectrometry.

J Proteome Res 2010 Aug;9(8):4082-4092

Henry Wellcome Building for Molecular Physiology, Department of Clinical Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, U.K.

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http://dx.doi.org/10.1021/pr100269bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681095PMC
August 2010

Comparison of CID versus ETD based MS/MS fragmentation for the analysis of protein ubiquitination.

J Am Soc Mass Spectrom 2009 Sep 18;20(9):1652-9. Epub 2009 May 18.

Oxford Centre for Gene Function/OXION, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1016/j.jasms.2009.04.023DOI Listing
September 2009

Structural basis and specificity of human otubain 1-mediated deubiquitination.

Biochem J 2009 Mar;418(2):379-90

Henry Wellcome Building for Molecular Physiology, Department of Clinical Medicine, University of Oxford, Roosevelt Drive, Oxford OX37BN, UK.

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http://dx.doi.org/10.1042/BJ20081318DOI Listing
March 2009

Site-selective glycosylation of proteins: creating synthetic glycoproteins.

Nat Protoc 2007 ;2(12):3185-94

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK.

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http://dx.doi.org/10.1038/nprot.2007.430DOI Listing
February 2008

Expanding the diversity of chemical protein modification allows post-translational mimicry.

Nature 2007 Apr;446(7139):1105-9

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, UK.

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http://www.nature.com/doifinder/10.1038/nature05757
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http://dx.doi.org/10.1038/nature05757DOI Listing
April 2007

Ligand amplification in a dynamic combinatorial glycopeptide library.

Chem Commun (Camb) 2005 Sep 9(34):4264-6. Epub 2005 Aug 9.

Department of Chemistry, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK.

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http://dx.doi.org/10.1039/b507674aDOI Listing
September 2005