Holger Heyn

Holger Heyn

UNVERIFIED PROFILE

Are you Holger Heyn?   Register this Author

Register author
Holger Heyn

Holger Heyn

Publications by authors named "Holger Heyn"

Are you Holger Heyn?   Register this Author

61Publications

2590Reads

48Profile Views

Three-Dimensional Genomic Structure and Cohesin Occupancy Correlate with Transcriptional Activity during Spermatogenesis.

Cell Rep 2019 Jul;28(2):352-367.e9

Departament de Biologia Cel.lular, Fisiologia i Immunologia, Universitat Autònoma de Barcelona (UAB), Cerdanyola del Vallès 08193, Spain; Genome Integrity and Instability Group, Institut de Biotecnologia i Biomedicina (IBB), Universitat Autònoma de Barcelona (UAB), Cerdanyola del Vallès 08193, Spain. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2019.06.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6635386PMC
July 2019

Single-cell transcriptomics unveils gene regulatory network plasticity.

Genome Biol 2019 06 4;20(1):110. Epub 2019 Jun 4.

CNAG-CRG, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Baldiri Reixac 4, 08028, Barcelona, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13059-019-1713-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547541PMC
June 2019

Tutorial: guidelines for the experimental design of single-cell RNA sequencing studies.

Nat Protoc 2018 12;13(12):2742-2757

CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41596-018-0073-y
Publisher Site
http://dx.doi.org/10.1038/s41596-018-0073-yDOI Listing
December 2018

Identity Noise and Adipogenic Traits Characterize Dermal Fibroblast Aging.

Cell 2018 11 8;175(6):1575-1590.e22. Epub 2018 Nov 8.

Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain; Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2018.10.012DOI Listing
November 2018

bigSCale: an analytical framework for big-scale single-cell data.

Genome Res 2018 06 3;28(6):878-890. Epub 2018 May 3.

CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/gr.230771.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991513PMC
June 2018

PM20D1 is a quantitative trait locus associated with Alzheimer's disease.

Nat Med 2018 05 7;24(5):598-603. Epub 2018 May 7.

Laboratory of Neuroepigenetics, Brain Mind Institute, Faculty of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41591-018-0013-yDOI Listing
May 2018

TRIM28 and Interacting KRAB-ZNFs Control Self-Renewal of Human Pluripotent Stem Cells through Epigenetic Repression of Pro-differentiation Genes.

Stem Cell Reports 2017 12 30;9(6):2065-2080. Epub 2017 Nov 30.

Laboratory for Gene Therapy, Department of Cancer Immunology, Poznan University of Medical Sciences, 60-806 Poznan, Poland; Laboratory for Gene Therapy, Department of Diagnostics and Cancer Immunology, Greater Poland Cancer Centre, 61-866 Poznan, Poland. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.stemcr.2017.10.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785758PMC
December 2017

Single-Cell Genomics Unravels Brain Cell-Type Complexity.

Adv Exp Med Biol 2017 ;978:393-407

CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), National Centre for Genomic Analysis (CNAG), Parc Científic de Barcelona - Torre I, Baldiri Reixac, 4, Barcelona, Catalonia, 08028, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-3-319-53889-1_20DOI Listing
September 2017

Copy number rather than epigenetic alterations are the major dictator of imprinted methylation in tumors.

Nat Commun 2017 09 7;8(1):467. Epub 2017 Sep 7.

Imprinting and Cancer group, Cancer Epigenetic and Biology Program (PEBC), Institut d'Investigació Biomedica de Bellvitge (IDIBELL), Avinguda Granvia, L'Hospitalet de Llobregat, 08907, Barcelona, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-017-00639-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589900PMC
September 2017

Whole genome grey and white matter DNA methylation profiles in dorsolateral prefrontal cortex.

Synapse 2017 06 6;71(6). Epub 2017 Feb 6.

School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Brain Mind Institute, Lausanne, CH-1015, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/syn.21959DOI Listing
June 2017

Mex3a Marks a Slowly Dividing Subpopulation of Lgr5+ Intestinal Stem Cells.

Cell Stem Cell 2017 06 9;20(6):801-816.e7. Epub 2017 Mar 9.

Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac 10, 08028 Barcelona, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), Pg. Lluís Companys 23, 08010 Barcelona, Spain. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.stem.2017.02.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5774992PMC
June 2017

Comparative Analysis of Single-Cell RNA Sequencing Methods.

Mol Cell 2017 Feb;65(4):631-643.e4

Anthropology & Human Genomics, Department of Biology II, Ludwig-Maximilians University, Großhaderner Straße 2, 82152 Martinsried, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molcel.2017.01.023DOI Listing
February 2017

Epigenetic profiling to classify cancer of unknown primary: a multicentre, retrospective analysis.

Lancet Oncol 2016 Oct 27;17(10):1386-1395. Epub 2016 Aug 27.

Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Barcelona, Catalonia, Spain; School of Medicine, University of Barcelona, Barcelona, Catalonia, Spain; Institucio Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S1470-2045(16)30297-2DOI Listing
October 2016

Cancer network activity associated with therapeutic response and synergism.

Genome Med 2016 08 24;8(1):88. Epub 2016 Aug 24.

Breast Cancer and Systems Biology Lab, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), Gran via 199, L'Hospitalet del Llobregat, Barcelona, 08908, Catalonia, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13073-016-0340-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995628PMC
August 2016

Quantitative Trait Loci Identify Functional Noncoding Variation in Cancer.

Authors:
Holger Heyn

PLoS Genet 2016 Mar 3;12(3):e1005826. Epub 2016 Mar 3.

Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), 08908 L'Hospitalet de Llobregat, Barcelona, Catalonia, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pgen.1005826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777413PMC
March 2016

Assessing associations between the AURKA-HMMR-TPX2-TUBG1 functional module and breast cancer risk in BRCA1/2 mutation carriers.

Authors:
Ignacio Blanco Karoline Kuchenbaecker Daniel Cuadras Xianshu Wang Daniel Barrowdale Gorka Ruiz de Garibay Pablo Librado Alejandro Sánchez-Gracia Julio Rozas Núria Bonifaci Lesley McGuffog Vernon S Pankratz Abul Islam Francesca Mateo Antoni Berenguer Anna Petit Isabel Català Joan Brunet Lidia Feliubadaló Eva Tornero Javier Benítez Ana Osorio Teresa Ramón y Cajal Heli Nevanlinna Kristiina Aittomäki Banu K Arun Amanda E Toland Beth Y Karlan Christine Walsh Jenny Lester Mark H Greene Phuong L Mai Robert L Nussbaum Irene L Andrulis Susan M Domchek Katherine L Nathanson Timothy R Rebbeck Rosa B Barkardottir Anna Jakubowska Jan Lubinski Katarzyna Durda Katarzyna Jaworska-Bieniek Kathleen Claes Tom Van Maerken Orland Díez Thomas V Hansen Lars Jønson Anne-Marie Gerdes Bent Ejlertsen Miguel de la Hoya Trinidad Caldés Alison M Dunning Clare Oliver Elena Fineberg Margaret Cook Susan Peock Emma McCann Alex Murray Chris Jacobs Gabriella Pichert Fiona Lalloo Carol Chu Huw Dorkins Joan Paterson Kai-Ren Ong Manuel R Teixeira Frans B L Hogervorst Annemarie H van der Hout Caroline Seynaeve Rob B van der Luijt Marjolijn J L Ligtenberg Peter Devilee Juul T Wijnen Matti A Rookus Hanne E J Meijers-Heijboer Marinus J Blok Ans M W van den Ouweland Cora M Aalfs Gustavo C Rodriguez Kelly-Anne A Phillips Marion Piedmonte Stacy R Nerenstone Victoria L Bae-Jump David M O'Malley Elena S Ratner Rita K Schmutzler Barbara Wappenschmidt Kerstin Rhiem Christoph Engel Alfons Meindl Nina Ditsch Norbert Arnold Hansjoerg J Plendl Dieter Niederacher Christian Sutter Shan Wang-Gohrke Doris Steinemann Sabine Preisler-Adams Karin Kast Raymonda Varon-Mateeva Andrea Gehrig Anders Bojesen Inge Sokilde Pedersen Lone Sunde Uffe Birk Jensen Mads Thomassen Torben A Kruse Lenka Foretova Paolo Peterlongo Loris Bernard Bernard Peissel Giulietta Scuvera Siranoush Manoukian Paolo Radice Laura Ottini Marco Montagna Simona Agata Christine Maugard Jacques Simard Penny Soucy Andreas Berger Anneliese Fink-Retter Christian F Singer Christine Rappaport Daphne Geschwantler-Kaulich Muy-Kheng Tea Georg Pfeiler Esther M John Alex Miron Susan L Neuhausen Mary Beth Terry Wendy K Chung Mary B Daly David E Goldgar Ramunas Janavicius Cecilia M Dorfling Elisabeth J van Rensburg Florentia Fostira Irene Konstantopoulou Judy Garber Andrew K Godwin Edith Olah Steven A Narod Gad Rennert Shani Shimon Paluch Yael Laitman Eitan Friedman Annelie Liljegren Johanna Rantala Marie Stenmark-Askmalm Niklas Loman Evgeny N Imyanitov Ute Hamann Amanda B Spurdle Sue Healey Jeffrey N Weitzel Josef Herzog David Margileth Chiara Gorrini Manel Esteller Antonio Gómez Sergi Sayols Enrique Vidal Holger Heyn Dominique Stoppa-Lyonnet Melanie Léoné Laure Barjhoux Marion Fassy-Colcombet Antoine de Pauw Christine Lasset Sandra Fert Ferrer Laurent Castera Pascaline Berthet François Cornelis Yves-Jean Bignon Francesca Damiola Sylvie Mazoyer Olga M Sinilnikova Christopher A Maxwell Joseph Vijai Mark Robson Noah Kauff Marina J Corines Danylko Villano Julie Cunningham Adam Lee Noralane Lindor Conxi Lázaro Douglas F Easton Kenneth Offit Georgia Chenevix-Trench Fergus J Couch Antonis C Antoniou Miguel Angel Pujana

PLoS One 2015 1;10(4):e0120020. Epub 2015 Apr 1.

Breast Cancer and Systems Biology Unit, Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Catalonia, Spain.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0120020PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382299PMC
December 2015

The interplay between DNA methylation and sequence divergence in recent human evolution.

Nucleic Acids Res 2015 Sep 13;43(17):8204-14. Epub 2015 Jul 13.

Institute of Evolutionary Biology (UPF-CSIC), PRBB, 08003 Barcelona, Spain Centro Nacional de Análisis Genómico (CNAG), Parc Científic de Barcelona, Barcelona 08028, Spain Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkv693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787803PMC
September 2015

KAT6B Is a Tumor Suppressor Histone H3 Lysine 23 Acetyltransferase Undergoing Genomic Loss in Small Cell Lung Cancer.

Cancer Res 2015 Sep 24;75(18):3936-45. Epub 2015 Jul 24.

Cancer Epigenetics Group, Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Catalonia, Spain. Department of Physiological Sciences II, School of Medicine, University of Barcelona, Barcelona, Catalonia, Spain. Institucio Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-14-3702DOI Listing
September 2015

DNA methylation dynamics in human carotid plaques after cerebrovascular events.

Arterioscler Thromb Vasc Biol 2015 Aug 18;35(8):1835-42. Epub 2015 Jun 18.

From the Division of Health Sciences, Department of Medical Sciences, León Campus, University of Guanajuato, León, Gto., Mexico (S.Z.); Experimental Cardiovascular Research and Department of Cardiology, Clinical Sciences Malmö, Lund University, Sweden (I.G.); Department of Clinical Sciences, Lund University, Malmö, Sweden (I.G.M.); Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Catalonia, Spain (F.J.C., A.G., H.H., S.M., N.V., M.E., S.Z.); Department of Physiological Sciences II, School of Medicine, University of Barcelona, Barcelona, Catalonia, Spain (M.E.); and Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain (M.E.).

View Article

Download full-text PDF

Source
https://www.ahajournals.org/doi/10.1161/ATVBAHA.115.305630
Publisher Site
http://dx.doi.org/10.1161/ATVBAHA.115.305630DOI Listing
August 2015

Epigenetic activation of a cryptic TBC1D16 transcript enhances melanoma progression by targeting EGFR.

Nat Med 2015 Jul 1;21(7):741-50. Epub 2015 Jun 1.

1] Cancer Epigenetics and Biology Program, Bellvitge Biomedical Research Institute, L'Hospitalet, Barcelona, Catalonia, Spain. [2] Department of Physiological Sciences II, School of Medicine, University of Barcelona, Barcelona, Catalonia, Spain. [3] Institucio Catalana de Recerca i Estudis Avançats, Barcelona, Catalonia, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nm.3863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968631PMC
July 2015

An Adenine Code for DNA: A Second Life for N6-Methyladenine.

Cell 2015 May 30;161(4):710-3. Epub 2015 Apr 30.

Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), 08908 L'Hospitalet de Llobregat, Barcelona, Catalonia, Spain; Department of Physiological Sciences II, School of Medicine, University of Barcelona, 08036 Barcelona, Catalonia, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010 Barcelona, Catalonia, Spain. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2015.04.021DOI Listing
May 2015

The DNA methylation drift of the atherosclerotic aorta increases with lesion progression.

BMC Med Genomics 2015 Feb 27;8. Epub 2015 Feb 27.

Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Av. Gran Vía s/n km. 2.7, 08907 L'Hospitalet de Llobregat, Barcelona, Catalonia, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12920-015-0085-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353677PMC
February 2015

DNA methylation map of human atherosclerosis.

Circ Cardiovasc Genet 2014 Oct 4;7(5):692-700. Epub 2014 Aug 4.

From the Division of Health Sciences, Department of Medical Sciences, University of Guanajuato, León, Guanajuato, Mexico (S.Z.); Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Catalonia, Spain (H.H., F.J.C., N.V., S.S., A.G., S.M., M.E.); Department of Pathology, Bellvitge University Hospital, Bellvitge Biomedical Research Institute (IDIBELL) (E.C.), Barcelona, Spain; Department of Pathology and Experimental Therapeutics (E.C.), Department of Anatomy and Pathology, Hospital Clinic (J.R.-R.), Department of Physiological Sciences II, School of Medicine (M.E.), University of Barcelona, Barcelona, Catalonia, Spain; Experimental Cardiovascular Research, Lund University, Malmö, Sweden (I.G.); and Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain (M.E.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCGENETICS.113.000441DOI Listing
October 2014

A comprehensive DNA methylation profile of epithelial-to-mesenchymal transition.

Cancer Res 2014 Oct 8;74(19):5608-19. Epub 2014 Aug 8.

Cancer Epigenetics and Biology Program, Bellvitge Biomedical Research Institute, L'Hospitalet de Llobregat; Barcelona, Spain. Department of Physiological Sciences II, School of Medicine, University of Barcelona, Barcelona, Spain. Institucio Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-13-3659DOI Listing
October 2014

A symbiotic liaison between the genetic and epigenetic code.

Authors:
Holger Heyn

Front Genet 2014 1;5:113. Epub 2014 May 1.

Cancer Epigenetics and Biology Program, Bellvitge Biomedical Research Institute Barcelona, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fgene.2014.00113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013453PMC
June 2014

Promoter hypermethylation of the phosphatase DUSP22 mediates PKA-dependent TAU phosphorylation and CREB activation in Alzheimer's disease.

Hippocampus 2014 Apr 28;24(4):363-8. Epub 2014 Jan 28.

Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Catalonia, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hipo.22245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233982PMC
April 2014

A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect.

Nat Commun 2014 Apr 3;5:3608. Epub 2014 Apr 3.

1] Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Barcelona, 08908 Catalonia, Spain [2] Department of Physiological Sciences II, School of Medicine, University of Barcelona, 08036 Barcelona, Spain [3] Institucio Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, 08010 Catalonia, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms4608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988805PMC
April 2014

Linkage of DNA methylation quantitative trait loci to human cancer risk.

Cell Rep 2014 Apr 3;7(2):331-338. Epub 2014 Apr 3.

Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, 08908 Barcelona, Catalonia, Spain; Department of Physiological Sciences II, School of Medicine, University of Barcelona, 08036 Barcelona, Catalonia, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010 Barcelona, Catalonia, Spain. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2014.03.016DOI Listing
April 2014

Epigenetic loss of the PIWI/piRNA machinery in human testicular tumorigenesis.

Epigenetics 2014 Jan 18;9(1):113-8. Epub 2013 Nov 18.

Cancer Epigenetics and Biology Program (PEBC); Bellvitge Biomedical Research Institute (IDIBELL); Barcelona, Spain; Department of Physiological Sciences II; School of Medicine; University of Barcelona; Barcelona, Spain; Institucio Catalana de Recerca i Estudis Avançats (ICREA); Barcelona, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4161/epi.27237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928173PMC
January 2014

A prognostic DNA methylation signature for stage I non-small-cell lung cancer.

J Clin Oncol 2013 Nov 30;31(32):4140-7. Epub 2013 Sep 30.

Juan Sandoval, Jesus Mendez-Gonzalez, F. Javier Carmona, Sergi Sayols, Sebastian Moran, Holger Heyn, Miguel Vizoso, Antonio Gomez, Montse Sanchez-Cespedes, and Manel Esteller, Bellvitge Biomedical Research Institute; Josefina Mora, Hospital de la Santa Creu i Sant Pau; Manel Esteller, University of Barcelona and Institucio Catalana de Recerca i Estudis Avançats, Barcelona; Miquel Taron and Rafael Rosell, Catalan Institute of Oncology, Badalona, Catalonia; Marina Pollan, Instituto de Salud Carlos III, Madrid; Maria J. Pajares and Luis M. Montuenga, University of Navarra; Wenceslao Torre, Clínica University de Navarra, Pamplona, Spain; Ernest Nadal, Guoan Chen, and David G. Beer, University of Michigan Medical School, Ann Arbor, MI; Yassen Assenov and Fabian Müller, Max Planck Institute, Saarbrücken, Germany; Christoph Bock, Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria; Lucia A. Muscarella, Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS) Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy; Triantafillos Liloglou, Michael Davies, and John K. Field, The University of Liverpool Cancer Research Centre, Liverpool, United Kingdom; Elisabeth Brambilla, Centre Hospitalier Universitaire A Michallon, Grenoble, France; Luca Roz, IRCCS Foundation National Cancer Institute, Milan; Marco Lo Iacono and Giorgio V. Scagliotti, University of Torino, Orbassano (Torino), Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1200/JCO.2012.48.5516DOI Listing
November 2013

DNA methylation contributes to natural human variation.

Genome Res 2013 Sep 1;23(9):1363-72. Epub 2013 Aug 1.

Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), 08908 L'Hospitalet de Llobregat, Barcelona, Catalonia, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/gr.154187.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759714PMC
September 2013

Epigenetic profiling joins personalized cancer medicine.

Expert Rev Mol Diagn 2013 Jun;13(5):473-9

Cancer Epigenetics and Biology Program PEBC, Bellvitge Biomedical Research Institute IDIBELL, 08908 L'Hospitalet de Llobregat, Barcelona, Catalonia, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1586/erm.13.36DOI Listing
June 2013

EZH2: an epigenetic gatekeeper promoting lymphomagenesis.

Cancer Cell 2013 May;23(5):563-5

Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, 08908 Barcelona, Catalonia, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccr.2013.04.028DOI Listing
May 2013

Epigenetic disruption of the PIWI pathway in human spermatogenic disorders.

PLoS One 2012 24;7(10):e47892. Epub 2012 Oct 24.

Cancer Epigenetics and Biology Program, Bellvitge Biomedical Research Institute, 08908 L'Hospitalet de Llobregat, Barcelona, Catalonia, Spain.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0047892PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480440PMC
April 2013

Genome-wide DNA methylation profiling predicts relapse in childhood B-cell acute lymphoblastic leukaemia.

Br J Haematol 2013 Feb 30;160(3):406-9. Epub 2012 Oct 30.

Cancer Epigenetics and Biology Programme, Bellvitge Biomedical Research Institute, L Hospitalet de Llobregat, Barcelona, Catalonia, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bjh.12113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568176PMC
February 2013

Aberrant DNA methylation profiles in the premature aging disorders Hutchinson-Gilford Progeria and Werner syndrome.

Epigenetics 2013 Jan 20;8(1):28-33. Epub 2012 Dec 20.

Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Catalonia, Spain.

View Article

Download full-text PDF

Source
http://www.tandfonline.com/doi/abs/10.4161/epi.23366
Publisher Site
http://dx.doi.org/10.4161/epi.23366DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549877PMC
January 2013

DNA methylation profiling in the clinic: applications and challenges.

Nat Rev Genet 2012 Oct 4;13(10):679-92. Epub 2012 Sep 4.

Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), 08908 L'Hospitalet de Llobregat, Barcelona, Catalonia, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrg3270DOI Listing
October 2012

Whole-genome bisulfite DNA sequencing of a DNMT3B mutant patient.

Epigenetics 2012 Jun 1;7(6):542-50. Epub 2012 Jun 1.

Cancer Epigenetics and Biology Program, Bellvitge Biomedical Research Institute, L'Hospitalet de Llobregat; Barcelona, Catalonia, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4161/epi.20523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398983PMC
June 2012

CpG island hypermethylation-associated silencing of small nucleolar RNAs in human cancer.

RNA Biol 2012 Jun 23;9(6):881-90. Epub 2012 May 23.

Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Catalonia, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4161/rna.19353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495749PMC
June 2012

Distinct DNA methylomes of newborns and centenarians.

Proc Natl Acad Sci U S A 2012 Jun 11;109(26):10522-7. Epub 2012 Jun 11.

Cancer Epigenetics and Biology Program, Spanish Biomedical Research Centre Network for Epidemiology and Public Health, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute, L’Hospitalet, Barcelona, Catalonia 08908, Spain.

View Article

Download full-text PDF

Source
http://www.pnas.org/cgi/doi/10.1073/pnas.1120658109
Publisher Site
http://dx.doi.org/10.1073/pnas.1120658109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387108PMC
June 2012

MicroRNA miR-548d is a superior regulator in pancreatic cancer.

Pancreas 2012 Mar;41(2):218-21

Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MPA.0b013e318224b701DOI Listing
March 2012

MicroRNA miR-335 is crucial for the BRCA1 regulatory cascade in breast cancer development.

Int J Cancer 2011 Dec 25;129(12):2797-806. Epub 2011 May 25.

Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ijc.25962DOI Listing
December 2011

Validation of a DNA methylation microarray for 450,000 CpG sites in the human genome.

Epigenetics 2011 Jun 1;6(6):692-702. Epub 2011 Jun 1.

Cancer Epigenetics and Biology Program (PEBC), Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4161/epi.6.6.16196DOI Listing
June 2011

Mutations in neutrophil elastase causing congenital neutropenia lead to cytoplasmic protein accumulation and induction of the unfolded protein response.

Blood 2006 Jul 21;108(2):493-500. Epub 2006 Mar 21.

Institute of Cell and Molecular Pathology, the Institute of Virology, the Department of Pediatric Hematology and Oncology, Hannover Medical School, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2005-11-4689DOI Listing
July 2006