Publications by authors named "Holger Cynis"

39Publications

Endogenous Retroviruses in Nervous System Disorders.

Authors:
Victoria Gröger Alexander Emmer Martin S Staege Holger Cynis

Pharmaceuticals (Basel) 2021 Jan 16;14(1). Epub 2021 Jan 16.

Department of Drug Design and Target Validation, Fraunhofer Institute for Cell Therapy and Immunology, 06120 Halle (Saale), Germany.

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January 2021

Acute targeting of pre-amyloid seeds in transgenic mice reduces Alzheimer-like pathology later in life.

Authors:
Ruth E Uhlmann Christine Rother Jay Rasmussen Juliane Schelle Carina Bergmann Emily M Ullrich Gavilanes Sarah K Fritschi Anika Buehler Frank Baumann Angelos Skodras Rawaa Al-Shaana Natalie Beschorner Lan Ye Stephan A Kaeser Ulrike Obermüller Søren Christensen Fredrik Kartberg Jeffrey B Stavenhagen Jens-Ulrich Rahfeld Holger Cynis Fang Qian Paul H Weinreb Thierry Bussiere Lary C Walker Matthias Staufenbiel Mathias Jucker

Nat Neurosci 2020 Dec 16;23(12):1580-1588. Epub 2020 Nov 16.

Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.

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December 2020

Targeting isoaspartate-modified Aβ rescues behavioral deficits in transgenic mice with Alzheimer's disease-like pathology.

Authors:
Kathrin Gnoth Anke Piechotta Martin Kleinschmidt Sandra Konrath Mathias Schenk Nadine Taudte Daniel Ramsbeck Vera Rieckmann Stefanie Geissler Rico Eichentopf Susan Barendrecht Maike Hartlage-Rübsamen Hans-Ulrich Demuth Steffen Roßner Holger Cynis Jens-Ulrich Rahfeld Stephan Schilling

Alzheimers Res Ther 2020 11 14;12(1):149. Epub 2020 Nov 14.

Department of Drug Design and Target Validation, Fraunhofer Institute for Cell Therapy and Immunology, Halle (Saale), Germany.

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November 2020

Formation of HERV-K and HERV-Fc1 Envelope Family Members is Suppressed on Transcriptional and Translational Level.

Authors:
Victoria Gröger Lisa Wieland Marcel Naumann Ann-Christin Meinecke Beate Meinhardt Steffen Rossner Christian Ihling Alexander Emmer Martin S Staege Holger Cynis

Int J Mol Sci 2020 Oct 23;21(21). Epub 2020 Oct 23.

Department of Drug Design and Target Validation, Fraunhofer Institute for Cell Therapy and Immunology, Weinbergweg 22, 06120 Halle, Germany.

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October 2020

Viromers as carriers for mRNA-mediated expression of therapeutic molecules under inflammatory conditions.

Authors:
Edith Jansig Stefanie Geissler Vera Rieckmann Anja Kuenemund Benjamin Hietel Mathias Schenk Sebastian Wussow Patrick Kreideweiss Steffen Panzner Christian Reinsch Holger Cynis

Sci Rep 2020 09 15;10(1):15090. Epub 2020 Sep 15.

Department of Drug Design and Target Validation, Fraunhofer Institute for Cell Therapy and Immunology, Weinbergweg 22, 06120, Halle, Germany.

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September 2020

Antifibrotic Effects of Amyloid-Beta and Its Loss in Cirrhotic Liver.

Authors:
Gayane Hrachia Buniatian Ralf Weiskirchen Thomas S Weiss Ute Schwinghammer Martin Fritz Torgom Seferyan Barbara Proksch Michael Glaser Ali Lourhmati Marine Buadze Erawan Borkham-Kamphorst Frank Gaunitz Christoph H Gleiter Thomas Lang Elke Schaeffeler Roman Tremmel Holger Cynis William H Frey Rolf Gebhardt Scott L Friedman Wolfgang Mikulits Matthias Schwab Lusine Danielyan

Cells 2020 02 17;9(2). Epub 2020 Feb 17.

Department of Clinical Pharmacology, University Hospital of Tübingen, 72076 Tübingen, Germany.

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February 2020

Novel reverse thia-analogs of fosmidomycin: Synthesis and antiplasmodial activity.

Authors:
Claudia Lienau Tobias Gräwert Leandro A Alves Avelar Boris Illarionov Jana Held Tanja C Knaab Beate Lungerich Lasse van Geelen Dieter Meier Stefanie Geissler Holger Cynis Ulrich Riederer Mirko Buchholz Rainer Kalscheuer Adelbert Bacher Benjamin Mordmüller Markus Fischer Thomas Kurz

Eur J Med Chem 2019 Nov 22;181:111555. Epub 2019 Jul 22.

Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitätsstr. 1, 40225, Düsseldorf, Germany. Electronic address:

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November 2019

Identification of human endogenous retrovirus transcripts in Hodgkin Lymphoma cells.

Authors:
Marie Barth Victoria Gröger Holger Cynis Martin Sebastian Staege

Mol Biol Rep 2019 Apr 1;46(2):1885-1893. Epub 2019 Feb 1.

University Clinic and Outpatient Clinic for Pediatrics I, Martin Luther University Halle-Wittenberg, Ernst-Grube-Str. 40, 06120, Halle, Germany.

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April 2019

Dipeptidyl-Peptidase Activity of Meprin β Links N-truncation of Aβ with Glutaminyl Cyclase-Catalyzed pGlu-Aβ Formation.

Authors:
Dagmar Schlenzig Holger Cynis Maike Hartlage-Rübsamen Ulrike Zeitschel Katja Menge Anja Fothe Daniel Ramsbeck Claudia Spahn Michael Wermann Steffen Roßner Mirko Buchholz Stephan Schilling Hans-Ulrich Demuth

J Alzheimers Dis 2018 ;66(1):359-375

Department of Molecular Drug Design and Target Validation Fraunhofer Institute for Cell Therapy and Immunology, Halle (Saale), Germany.

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September 2019

Kallikrein-related peptidases are activators of the CC chemokine CCL14.

Authors:
Mario Grünberg Dagmar Quandt Holger Cynis Hans-Ulrich Demuth Andrea Kindermann Viktor Magdolen Wolf-Georg Forssmann Barbara Seliger Hans-Jürgen Mägert

Eur J Immunol 2018 09 22;48(9):1592-1594. Epub 2018 Aug 22.

Anhalt University of Applied Sciences, Molecular Biotechnology, Köthen, Germany.

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September 2018

Structure-Guided Design, Synthesis, and Characterization of Next-Generation Meprin β Inhibitors.

Authors:
Daniel Ramsbeck Antje Hamann Georg Richter Dagmar Schlenzig Stefanie Geissler Vera Nykiel Holger Cynis Stephan Schilling Mirko Buchholz

J Med Chem 2018 05 7;61(10):4578-4592. Epub 2018 May 7.

Fraunhofer Institute for Cell Therapy and Immunology IZI , Department of Drug Design and Target Validation MWT , Biocenter, Weinbergweg 22 , 06120 Halle (Saale) , Germany.

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May 2018

Human Endogenous Retroviruses and Their Putative Role in the Development of Autoimmune Disorders Such as Multiple Sclerosis.

Authors:
Victoria Gröger Holger Cynis

Front Microbiol 2018 20;9:265. Epub 2018 Feb 20.

Department of Drug Design and Target Validation, Fraunhofer Institute for Cell Therapy and Immunology, Halle, Germany.

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February 2018

N-terminal pyroglutamate formation in CX3CL1 is essential for its full biologic activity.

Authors:
Astrid Kehlen Monique Haegele Livia Böhme Holger Cynis Torsten Hoffmann Hans-Ulrich Demuth

Biosci Rep 2017 Aug 23;37(4). Epub 2017 Aug 23.

Probiodrug AG, Weinbergweg 22, Halle (Saale) 06120, Germany

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August 2017

Immunotherapy targeting pyroglutamate-3 Aβ: prospects and challenges.

Authors:
Holger Cynis Jeffrey L Frost Helen Crehan Cynthia A Lemere

Mol Neurodegener 2016 06 30;11(1):48. Epub 2016 Jun 30.

Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, NRB636, Boston, MA, 02115, USA.

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June 2016

IsoQC (QPCTL) knock-out mice suggest differential substrate conversion by glutaminyl cyclase isoenzymes.

Authors:
Andreas Becker Rico Eichentopf Reinhard Sedlmeier Alexander Waniek Holger Cynis Birgit Koch Anett Stephan Christoph Bäuscher Stephanie Kohlmann Torsten Hoffmann Astrid Kehlen Sabine Berg Ernst-Joachim Freyse Alexander Osmand Anne-Christine Plank Steffen Roßner Stephan von Hörsten Sigrid Graubner Hans-Ulrich Demuth Stephan Schilling

Biol Chem 2016 Jan;397(1):45-55

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January 2016

Isoglutaminyl cyclase contributes to CCL2-driven neuroinflammation in Alzheimer's disease.

Authors:
Maike Hartlage-Rübsamen Alexander Waniek Juliane Meissner Markus Morawski Stephan Schilling Carsten Jäger Martin Kleinschmidt Holger Cynis Astrid Kehlen Thomas Arendt Hans-Ulrich Demuth Steffen Rossner

Acta Neuropathol 2015 Apr 11;129(4):565-83. Epub 2015 Feb 11.

Paul Flechsig Institute for Brain Research, University of Leipzig, Jahnallee 59, 04109, Leipzig, Germany.

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April 2015

Pyroglutamate-amyloid-β and glutaminyl cyclase are colocalized with amyloid-β in secretory vesicles and undergo activity-dependent, regulated secretion.

Authors:
Holger Cynis Lydiane Funkelstein Thomas Toneff Charles Mosier Michael Ziegler Birgit Koch Hans-Ulrich Demuth Vivian Hook

Neurodegener Dis 2014 18;14(2):85-97. Epub 2014 Jun 18.

Fraunhofer IZJ-MWT, Halle, Germany.

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May 2015

Mouse strain and brain region-specific expression of the glutaminyl cyclases QC and isoQC.

Authors:
Corinna Höfling Henrike Indrischek Theodor Höpcke Alexander Waniek Holger Cynis Birgit Koch Stephan Schilling Markus Morawski Hans-Ulrich Demuth Steffen Roßner Maike Hartlage-Rübsamen

Int J Dev Neurosci 2014 Aug 2;36:64-73. Epub 2014 Jun 2.

Paul Flechsig Institute for Brain Research, University of Leipzig, Leipzig, Germany.

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August 2014

Glutaminyl cyclase in human cortex: correlation with (pGlu)-amyloid-β load and cognitive decline in Alzheimer's disease.

Authors:
Markus Morawski Stephan Schilling Moritz Kreuzberger Alexander Waniek Carsten Jäger Birgit Koch Holger Cynis Astrid Kehlen Thomas Arendt Maike Hartlage-Rübsamen Hans-Ulrich Demuth Steffen Roßner

J Alzheimers Dis 2014 ;39(2):385-400

Paul Flechsig Institute for Brain Research, University of Leipzig, Leipzig, Germany.

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October 2014

Glutaminyl cyclase-mediated toxicity of pyroglutamate-beta amyloid induces striatal neurodegeneration.

Authors:
Andreas Becker Stephanie Kohlmann Anca Alexandru Wolfgang Jagla Fabio Canneva Christoph Bäuscher Holger Cynis Reinhard Sedlmeier Sigrid Graubner Stephan Schilling Hans-Ulrich Demuth Stephan von Hörsten

BMC Neurosci 2013 Oct 1;14:108. Epub 2013 Oct 1.

Department of Experimental Therapy, Friedrich-Alexander-University Erlangen-Nürnberg, Palmsanlage 5, 91054 Erlangen, Germany.

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October 2013