Publications by authors named "Ho-Keung Ng"

100Publications

Low-grade BRAF V600E mutant oligodendroglioma-like tumors of children may show EGFR and MET amplification.

Brain Pathol 2020 Oct 8:e12904. Epub 2020 Oct 8.

Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, 30-32 Ngan Shing Street, Shatin, Hong Kong, China SAR.

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http://dx.doi.org/10.1111/bpa.12904DOI Listing
October 2020

Highlights of the inaugural ten - the launch of Neuro-Oncology Advances.

Neurooncol Adv 2019 May-Dec;1(1):vdz016. Epub 2019 Aug 28.

Division of Neurosurgery, University Health Network and MacFeeters-Hamilton Neuro-Oncology Program, Princess Margaret Hospital, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1093/noajnl/vdz016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212904PMC
August 2019

Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes.

Authors:
Matthew Clarke Alan Mackay Britta Ismer Jessica C Pickles Ruth G Tatevossian Scott Newman Tejus A Bale Iris Stoler Elisa Izquierdo Sara Temelso Diana M Carvalho Valeria Molinari Anna Burford Louise Howell Alex Virasami Amy R Fairchild Aimee Avery Jane Chalker Mark Kristiansen Kelly Haupfear James D Dalton Wilda Orisme Ji Wen Michael Hubank Kathreena M Kurian Catherine Rowe Mellissa Maybury Stephen Crosier Jeffrey Knipstein Ulrich Schüller Uwe Kordes David E Kram Matija Snuderl Leslie Bridges Andrew J Martin Lawrence J Doey Safa Al-Sarraj Christopher Chandler Bassel Zebian Claire Cairns Rachael Natrajan Jessica K R Boult Simon P Robinson Martin Sill Ira J Dunkel Stephen W Gilheeney Marc K Rosenblum Debbie Hughes Paula Z Proszek Tobey J Macdonald Matthias Preusser Christine Haberler Irene Slavc Roger Packer Ho-Keung Ng Shani Caspi Mara Popović Barbara Faganel Kotnik Matthew D Wood Lissa Baird Monika Ashok Davare David A Solomon Thale Kristin Olsen Petter Brandal Michael Farrell Jane B Cryan Michael Capra Michael Karremann Jens Schittenhelm Martin U Schuhmann Martin Ebinger Winand N M Dinjens Kornelius Kerl Simone Hettmer Torsten Pietsch Felipe Andreiuolo Pablo Hernáiz Driever Andrey Korshunov Lotte Hiddingh Barbara C Worst Dominik Sturm Marc Zuckermann Olaf Witt Tabitha Bloom Clare Mitchell Evelina Miele Giovanna Stefania Colafati Francesca Diomedi-Camassei Simon Bailey Andrew S Moore Timothy E G Hassall Stephen P Lowis Maria Tsoli Mark J Cowley David S Ziegler Matthias A Karajannis Kristian Aquilina Darren R Hargrave Fernando Carceller Lynley V Marshall Andreas von Deimling Christof M Kramm Stefan M Pfister Felix Sahm Suzanne J Baker Angela Mastronuzzi Andrea Carai Maria Vinci David Capper Sergey Popov David W Ellison Thomas S Jacques David T W Jones Chris Jones

Cancer Discov 2020 Jul 1;10(7):942-963. Epub 2020 Apr 1.

Division of Molecular Pathology, Institute of Cancer Research, London, United Kingdom.

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http://dx.doi.org/10.1158/2159-8290.CD-19-1030DOI Listing
July 2020

Bioethics Education in the Medical Programme among Malaysian Medical Schools: Where Are We Now?

J Med Educ Curric Dev 2019 Jan-Dec;6:2382120519883887. Epub 2019 Dec 2.

Office of Medical Education, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.

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http://dx.doi.org/10.1177/2382120519883887DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6887801PMC
December 2019

Longitudinal molecular trajectories of diffuse glioma in adults.

Nature 2019 12 20;576(7785):112-120. Epub 2019 Nov 20.

The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.

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http://dx.doi.org/10.1038/s41586-019-1775-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6897368PMC
December 2019

Identification of subsets of -mutant glioblastomas with distinct epigenetic and copy number alterations and stratified clinical risks.

Neurooncol Adv 2019 May-Dec;1(1):vdz015. Epub 2019 Jul 17.

Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China.

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http://dx.doi.org/10.1093/noajnl/vdz015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6798792PMC
July 2019

Recurrent noncoding U1 snRNA mutations drive cryptic splicing in SHH medulloblastoma.

Nature 2019 10 9;574(7780):707-711. Epub 2019 Oct 9.

The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/s41586-019-1650-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141958PMC
October 2019

Whole-exome sequencing revealed mutational profiles of giant cell glioblastomas.

Brain Pathol 2019 11 10;29(6):782-792. Epub 2019 Apr 10.

Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, 30-32 Ngan Shing Street, Shatin, Hong Kong, China.

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http://doi.wiley.com/10.1111/bpa.12720
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http://dx.doi.org/10.1111/bpa.12720DOI Listing
November 2019

Pediatric low-grade gliomas can be molecularly stratified for risk.

Acta Neuropathol 2018 10 14;136(4):641-655. Epub 2018 Jun 14.

Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, 30-32 Ngan Shing Street, Shatin, Hong Kong SAR, China.

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http://dx.doi.org/10.1007/s00401-018-1874-3DOI Listing
October 2018

Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort.

Lancet Oncol 2018 06 9;19(6):785-798. Epub 2018 May 9.

Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany; Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany; Hopp Children's Cancer Center at the NCT Heidelberg, Heidelberg, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14702045183024
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http://dx.doi.org/10.1016/S1470-2045(18)30242-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984248PMC
June 2018

Histological Characteristics of Intracranial Atherosclerosis in a Chinese Population: A Postmortem Study.

Front Neurol 2017 25;8:488. Epub 2017 Sep 25.

Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong.

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http://dx.doi.org/10.3389/fneur.2017.00488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622314PMC
September 2017

Glioma groups classified by IDH and TERT promoter mutations remain stable among primary and recurrent gliomas.

Neuro Oncol 2017 07;19(7):1008-1010

Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China; Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China; Neurosurgical Immunology Laboratory of Huashan Hospital, Fudan University, Shanghai, China; Department of Pathology, Basic Medical Science, Fudan University, Shanghai, China; Department of Neuropathology, Huashan Hospital, Fudan University, Shanghai, China.

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http://dx.doi.org/10.1093/neuonc/nox042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570184PMC
July 2017

Therapeutic and Prognostic Implications of BRAF V600E in Pediatric Low-Grade Gliomas.

J Clin Oncol 2017 Sep 20;35(25):2934-2941. Epub 2017 Jul 20.

Alvaro Lassaletta, Michal Zapotocky, Matthew Mistry, Vijay Ramaswamy, Marion Honnorat, Rahul Krishnatry, Ana Guerreiro Stucklin, Nataliya Zhukova, Anthony Arnoldo, Scott Ryall, Catriona Ling, Tara McKeown, Jim Loukides, James T. Rutka, Peter Dirks, Michael D. Taylor, Shiyi Chen, Ute Bartels, Annie Huang, Eric Bouffet, Cynthia Hawkins, and Uri Tabori, The Hospital for Sick Children, Toronto; Adam Fleming, McMaster Children's Hospital, McMaster University, Hamilton; Shayna Zelcer, Children's Hospital of Western Ontario, London, Ontario; David Eisenstat and Bev Wilson, Stollery Children's Hospital, University of Alberta, Edmonton, Alberta; Anne Sophie Carret, Hospital Sainte Justine; Nada Jabado, McGill University, Montreal; Valerie Larouche, Centre Hospitalier Universitaire de Québec, Québec City, Quebec, Canada; Ofelia Cruz and Carmen de Torres, Hospital Sant Joan de Déu, Barcelona, Spain; Cheng-Ying Ho, University of Maryland School of Medicine, Baltimore, MD; Roger J. Packer, Children's National Health System, Washington, DC; Ruth Tatevossian, Ibrahim Qaddoumi, Julie H. Harreld, James D. Dalton, and David W. Ellison, St Jude Children's Research Hospital, Memphis, TN; Jean Mulcahy-Levy and Nicholas Foreman, Children's Hospital Colorado, Aurora, CO; Matthias A. Karajannis, Shiyang Wang, and Matija Snuderl, New York University Langone Medical Center, New York, NY; Amulya Nageswara Rao and Caterina Giannini, The Mayo Clinic, Rochester, MN; Mark Kieran and Keith L. Ligon, Dana-Farber Cancer Institute, Boston Children's Hospital, Boston, MA; Maria Luisa Garre, Paolo Nozza, Samantha Mascelli, and Alessandro Raso, Istituto Giannina Gaslini, Genoa, Italy; Sabine Mueller and Theodore Nicolaides, University of California, San Francisco, San Francisco, CA; Karen Silva and Romain Perbet, Hospices Civils de Lyon; Alexandre Vasiljevic, Cécile Faure Conter, and Didier Frappaz, Institute of Pediatric Hematology and Oncology, Lyon, France; Sarah Leary and Courtney Crane, Seattle Children's Hospital, Seattle, WA; Aden Chan and Ho-Keung Ng, The Chinese University of Hong Kong, Hong Kong; Zhi-Feng Shi and Ying Mao, Huashan Hospital, Fudan University, Shanghai, People's Republic of China; Elizabeth Finch, University of North Carolina, School of Medicine, Chapel Hill, NC; Peter Hauser, Semmelweis University, Budapest, Hungary; and David Sumerauer and Lenka Krskova, University Hospital Motol, Charles University, 2nd Medical School, Prague, Czech Republic.

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http://dx.doi.org/10.1200/JCO.2016.71.8726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791837PMC
September 2017

Intertumoral Heterogeneity within Medulloblastoma Subgroups.

Authors:
Florence M G Cavalli Marc Remke Ladislav Rampasek John Peacock David J H Shih Betty Luu Livia Garzia Jonathon Torchia Carolina Nor A Sorana Morrissy Sameer Agnihotri Yuan Yao Thompson Claudia M Kuzan-Fischer Hamza Farooq Keren Isaev Craig Daniels Byung-Kyu Cho Seung-Ki Kim Kyu-Chang Wang Ji Yeoun Lee Wieslawa A Grajkowska Marta Perek-Polnik Alexandre Vasiljevic Cecile Faure-Conter Anne Jouvet Caterina Giannini Amulya A Nageswara Rao Kay Ka Wai Li Ho-Keung Ng Charles G Eberhart Ian F Pollack Ronald L Hamilton G Yancey Gillespie James M Olson Sarah Leary William A Weiss Boleslaw Lach Lola B Chambless Reid C Thompson Michael K Cooper Rajeev Vibhakar Peter Hauser Marie-Lise C van Veelen Johan M Kros Pim J French Young Shin Ra Toshihiro Kumabe Enrique López-Aguilar Karel Zitterbart Jaroslav Sterba Gaetano Finocchiaro Maura Massimino Erwin G Van Meir Satoru Osuka Tomoko Shofuda Almos Klekner Massimo Zollo Jeffrey R Leonard Joshua B Rubin Nada Jabado Steffen Albrecht Jaume Mora Timothy E Van Meter Shin Jung Andrew S Moore Andrew R Hallahan Jennifer A Chan Daniela P C Tirapelli Carlos G Carlotti Maryam Fouladi José Pimentel Claudia C Faria Ali G Saad Luca Massimi Linda M Liau Helen Wheeler Hideo Nakamura Samer K Elbabaa Mario Perezpeña-Diazconti Fernando Chico Ponce de León Shenandoah Robinson Michal Zapotocky Alvaro Lassaletta Annie Huang Cynthia E Hawkins Uri Tabori Eric Bouffet Ute Bartels Peter B Dirks James T Rutka Gary D Bader Jüri Reimand Anna Goldenberg Vijay Ramaswamy Michael D Taylor

Cancer Cell 2017 06;31(6):737-754.e6

The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A1, Canada; Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163053PMC
June 2017

Adult IDH wild-type lower-grade gliomas should be further stratified.

Neuro Oncol 2017 Oct;19(10):1327-1337

Department of Anatomical and Cellular Pathology, Faculty of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China; Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China); Department of Pathology, Huashan Hospital, Fudan University, Shanghai, China.

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http://dx.doi.org/10.1093/neuonc/nox078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596181PMC
October 2017

The kinesin KIF14 is overexpressed in medulloblastoma and downregulation of KIF14 suppressed tumor proliferation and induced apoptosis.

Lab Invest 2017 08 15;97(8):946-961. Epub 2017 May 15.

Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, China.

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http://dx.doi.org/10.1038/labinvest.2017.48DOI Listing
August 2017

Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors.

Authors:
Jonathon Torchia Brian Golbourn Shengrui Feng King Ching Ho Patrick Sin-Chan Alexandre Vasiljevic Joseph D Norman Paul Guilhamon Livia Garzia Natalia R Agamez Mei Lu Tiffany S Chan Daniel Picard Pasqualino de Antonellis Dong-Anh Khuong-Quang Aline C Planello Constanze Zeller Dalia Barsyte-Lovejoy Lucie Lafay-Cousin Louis Letourneau Mathieu Bourgey Man Yu Deena M A Gendoo Misko Dzamba Mark Barszczyk Tiago Medina Alexandra N Riemenschneider A Sorana Morrissy Young-Shin Ra Vijay Ramaswamy Marc Remke Christopher P Dunham Stephen Yip Ho-Keung Ng Jian-Qiang Lu Vivek Mehta Steffen Albrecht Jose Pimentel Jennifer A Chan Gino R Somers Claudia C Faria Lucia Roque Maryam Fouladi Lindsey M Hoffman Andrew S Moore Yin Wang Seung Ah Choi Jordan R Hansford Daniel Catchpoole Diane K Birks Nicholas K Foreman Doug Strother Almos Klekner Laszló Bognár Miklós Garami Péter Hauser Tibor Hortobágyi Beverly Wilson Juliette Hukin Anne-Sophie Carret Timothy E Van Meter Eugene I Hwang Amar Gajjar Shih-Hwa Chiou Hideo Nakamura Helen Toledano Iris Fried Daniel Fults Takafumi Wataya Chris Fryer David D Eisenstat Katrin Scheinemann Adam J Fleming Donna L Johnston Jean Michaud Shayna Zelcer Robert Hammond Samina Afzal David A Ramsay Nongnuch Sirachainan Suradej Hongeng Noppadol Larbcharoensub Richard G Grundy Rishi R Lulla Jason R Fangusaro Harriet Druker Ute Bartels Ronald Grant David Malkin C Jane McGlade Theodore Nicolaides Tarik Tihan Joanna Phillips Jacek Majewski Alexandre Montpetit Guillaume Bourque Gary D Bader Alyssa T Reddy G Yancey Gillespie Monika Warmuth-Metz Stefan Rutkowski Uri Tabori Mathieu Lupien Michael Brudno Ulrich Schüller Torsten Pietsch Alexander R Judkins Cynthia E Hawkins Eric Bouffet Seung-Ki Kim Peter B Dirks Michael D Taylor Anat Erdreich-Epstein Cheryl H Arrowsmith Daniel D De Carvalho James T Rutka Nada Jabado Annie Huang

Cancer Cell 2016 Dec;30(6):891-908

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4, Canada; Department of Paediatrics, University of Toronto, Toronto, ON M5G0A4, Canada; Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500911PMC
December 2016

TP53 and Histone H3.3 Mutations in Triple-Negative Lower-Grade Gliomas.

N Engl J Med 2016 12;375(22):2206-2208

Chinese University of Hong Kong, Hong Kong, China

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http://dx.doi.org/10.1056/NEJMc1610144DOI Listing
December 2016

Postmortem Study of Validation of Low Signal on Fat-Suppressed T1-Weighted Magnetic Resonance Imaging as Marker of Lipid Core in Middle Cerebral Artery Atherosclerosis.

Stroke 2016 09 26;47(9):2299-304. Epub 2016 Jul 26.

From the Department of Medicine and Therapeutics (W.-J.Y., X.-Y.C., K.-S.W.) and Department of Anatomical and Cellular Pathology (H.-K.N.), Chinese University of Hong Kong, Shatin, Hong Kong SAR, China; Centre for Diabetic Systems Medicine, Guangxi Key Laboratory of Excellence, Guilin Medical University, Guilin, China (H.-L.Z.); Department of Pathology, China-Japan Union Hospital Affiliated to Jilin University, China (C.-B.N.); and Department of Radiology (B.Z.) and Department of Neurology (Y.X.), Affiliated Drum Tower Hospital of Nanjing University Medical School, China.

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http://dx.doi.org/10.1161/STROKEAHA.116.013398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991347PMC
September 2016

Clinicopathological analysis of UHRF1 expression in medulloblastoma tissues and its regulation on tumor cell proliferation.

Med Oncol 2016 Sep 23;33(9):99. Epub 2016 Jul 23.

Department of Neurosurgery, Huashan Hospital, Fudan University, Wulumuqi Zhong Road 12, Shanghai, 200040, China.

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http://dx.doi.org/10.1007/s12032-016-0799-8DOI Listing
September 2016

A 14-Year-Old Boy with Left Temporal Mass.

Brain Pathol 2016 Mar;26(2):293-4

CUHK Otto Wong Brain Tumour Centre, Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China.

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http://dx.doi.org/10.1111/bpa.12360DOI Listing
March 2016

Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis.

Authors:
Eric M Thompson Thomas Hielscher Eric Bouffet Marc Remke Betty Luu Sridharan Gururangan Roger E McLendon Darell D Bigner Eric S Lipp Sebastien Perreault Yoon-Jae Cho Gerald Grant Seung-Ki Kim Ji Yeoun Lee Amulya A Nageswara Rao Caterina Giannini Kay Ka Wai Li Ho-Keung Ng Yu Yao Toshihiro Kumabe Teiji Tominaga Wieslawa A Grajkowska Marta Perek-Polnik David C Y Low Wan Tew Seow Kenneth T E Chang Jaume Mora Ian F Pollack Ronald L Hamilton Sarah Leary Andrew S Moore Wendy J Ingram Andrew R Hallahan Anne Jouvet Michelle Fèvre-Montange Alexandre Vasiljevic Cecile Faure-Conter Tomoko Shofuda Naoki Kagawa Naoya Hashimoto Nada Jabado Alexander G Weil Tenzin Gayden Takafumi Wataya Tarek Shalaby Michael Grotzer Karel Zitterbart Jaroslav Sterba Leos Kren Tibor Hortobágyi Almos Klekner Bognár László Tímea Pócza Peter Hauser Ulrich Schüller Shin Jung Woo-Youl Jang Pim J French Johan M Kros Marie-Lise C van Veelen Luca Massimi Jeffrey R Leonard Joshua B Rubin Rajeev Vibhakar Lola B Chambless Michael K Cooper Reid C Thompson Claudia C Faria Alice Carvalho Sofia Nunes José Pimentel Xing Fan Karin M Muraszko Enrique López-Aguilar David Lyden Livia Garzia David J H Shih Noriyuki Kijima Christian Schneider Jennifer Adamski Paul A Northcott Marcel Kool David T W Jones Jennifer A Chan Ana Nikolic Maria Luisa Garre Erwin G Van Meir Satoru Osuka Jeffrey J Olson Arman Jahangiri Brandyn A Castro Nalin Gupta William A Weiss Iska Moxon-Emre Donald J Mabbott Alvaro Lassaletta Cynthia E Hawkins Uri Tabori James Drake Abhaya Kulkarni Peter Dirks James T Rutka Andrey Korshunov Stefan M Pfister Roger J Packer Vijay Ramaswamy Michael D Taylor

Lancet Oncol 2016 04 12;17(4):484-495. Epub 2016 Mar 12.

Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON, Canada; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14702045150058
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http://dx.doi.org/10.1016/S1470-2045(15)00581-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907853PMC
April 2016

In Vitro Assessment of Histology Verified Intracranial Atherosclerotic Disease by 1.5T Magnetic Resonance Imaging: Concentric or Eccentric?

Stroke 2016 Feb 1;47(2):527-30. Epub 2015 Dec 1.

From the Department of Medicine and Therapeutics (W.-J.Y., X.-Y.C., K.-S.W.) and Department of Anatomical and Cellular Pathology (H.-K.N.), Chinese University of Hong Kong, Shatin, Hong Kong SAR, China; Faculty of Basic Medicine, Guilin Medical University, Guilin, China (H.-L.Z.); Department of Pathology, China-Japan Union Hospital Affiliated to Jilin University, Jilin, China (C.-B.N.); and Department of Neurology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, PR China (Y.X.).

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http://dx.doi.org/10.1161/STROKEAHA.115.011086DOI Listing
February 2016

Signaling pathway and molecular subgroups of medulloblastoma. Int J Clin Exp Pathol. 2013; 6(7): 1211-22.

Int J Clin Exp Pathol 2015 1;8(9):11945. Epub 2015 Sep 1.

Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong Hong Kong ; Shenzhen Research Institute, The Chinese University of Hong Kong No. 10, 2nd Yuexing Road, Nanshan District, Shenzhen 518057, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637768PMC
March 2016

Glioma Association and Balancing Selection of ZFPM2.

PLoS One 2015 24;10(7):e0133003. Epub 2015 Jul 24.

Division of Life Science and Applied Genomics Centre, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0133003PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4514883PMC
May 2016

CRMP1 Inhibits Proliferation of Medulloblastoma and Is Regulated by HMGA1.

PLoS One 2015 26;10(5):e0127910. Epub 2015 May 26.

Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong, Prince of Wales Hospital, 30-32 Ngan Shing Street, Shatin, Hong Kong, China; Shenzhen Research Institute, The Chinese University of Hong Kong, No.10, 2nd Yuexing Road, Nanshan District, Shenzhen, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0127910PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444180PMC
April 2016

Molecular subgroups of atypical teratoid rhabdoid tumours in children: an integrated genomic and clinicopathological analysis.

Lancet Oncol 2015 May 14;16(5):569-82. Epub 2015 Apr 14.

Division of Hematology-Oncology, University of Toronto, Toronto, ON, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; Department of Pediatrics, University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(15)70114-2DOI Listing
May 2015

Surgically treated incidentally discovered low-grade gliomas are mostly IDH mutated and 1p19q co-deleted with favorable prognosis.

Int J Clin Exp Pathol 2014 1;7(12):8627-36. Epub 2014 Dec 1.

Department of Neurosurgery, Huashan Hospital, Fudan University 12 Wulumuqi Zhong Road, Shanghai 200040, China.

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http://www.ijcep.com/files/ijcep0003247.pdf
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313984PMC
October 2015

Atypical intracranial epidermoid cysts: rare anomalies with unique radiological features.

Case Rep Radiol 2015 15;2015:528632. Epub 2015 Jan 15.

Department of Anatomical & Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong.

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http://dx.doi.org/10.1155/2015/528632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312626PMC
February 2015

Spinal nerve root haemangioblastoma associated with reactive polycythemia.

Case Rep Radiol 2014 6;2014:798620. Epub 2014 Nov 6.

Department of Anatomical & Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong.

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http://dx.doi.org/10.1155/2014/798620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241257PMC
November 2014

TERT promoter mutations contribute to subset prognostication of lower-grade gliomas.

Mod Pathol 2015 Feb 1;28(2):177-86. Epub 2014 Aug 1.

1] Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong, China [2] The Chinese University of Hong Kong-Shenzhen Research Institute, Shenzhen, China.

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http://dx.doi.org/10.1038/modpathol.2014.94DOI Listing
February 2015

miR-106b is overexpressed in medulloblastomas and interacts directly with PTEN.

Neuropathol Appl Neurobiol 2015 Feb;41(2):145-64

Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China; Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, China.

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http://dx.doi.org/10.1111/nan.12169DOI Listing
February 2015

Novel somatic and germline mutations in intracranial germ cell tumours.

Nature 2014 Jul 4;511(7508):241-5. Epub 2014 Jun 4.

1] Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, Texas 77030, USA [2] Medical Scientist Training Program, Baylor College of Medicine, Houston, Texas 77030, USA [3] Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1038/nature13296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532372PMC
July 2014

Curcumin suppresses cell proliferation through inhibition of the Wnt/β-catenin signaling pathway in medulloblastoma.

Oncol Rep 2014 Jul 22;32(1):173-80. Epub 2014 May 22.

Department of Pathophysiology, Chongqing Medical University, Chongqing, P.R. China.

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http://dx.doi.org/10.3892/or.2014.3206DOI Listing
July 2014

A sequential comparison on the risk of haemorrhage with different sizes of biopsy needles for stereotactic brain biopsy.

Stereotact Funct Neurosurg 2014 10;92(3):160-9. Epub 2014 May 10.

Division of Neurosurgery, Department of Surgery, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong, SAR, China.

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http://dx.doi.org/10.1159/000360862DOI Listing
February 2015

High signal on T1 sequence of magnetic resonance imaging confirmed to be intraplaque haemorrhage by histology in middle cerebral artery.

Int J Stroke 2014 Jun;9(4):E19

Departments of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.

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http://dx.doi.org/10.1111/ijs.12277DOI Listing
June 2014

Neuropathology of cigarette smoking.

Acta Neuropathol 2014 Jan 16;127(1):53-69. Epub 2013 Nov 16.

Laboratory of Neurodegenerative Diseases, Department of Anatomy, LKS Faculty of Medicine, The University of Hong Kong, Rm. L1-49, Laboratory Block, Faculty of Medicine Building, 21 Sassoon Road, Pokfulam, Hong Kong,

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http://dx.doi.org/10.1007/s00401-013-1210-xDOI Listing
January 2014

Loss of CIC and FUBP1 expressions are potential markers of shorter time to recurrence in oligodendroglial tumors.

Mod Pathol 2014 Mar 13;27(3):332-42. Epub 2013 Sep 13.

1] Department of Anatomical and Cellular Pathology, Chinese University of Hong Kong, Hong Kong, China [2] The Chinese University of Hong Kong-Shenzhen Research Institute, Shenzhen, China.

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http://dx.doi.org/10.1038/modpathol.2013.165DOI Listing
March 2014

TGM2 inhibition attenuates ID1 expression in CD44-high glioma-initiating cells.

Neuro Oncol 2013 Oct 21;15(10):1353-65. Epub 2013 Jul 21.

Corresponding Author: Zhong-ping Chen, MD, PhD, Department of Neurosurgery/Neuro-oncology, Cancer Center, Sun Yat-Sen University, Guangzhou 510060, China.

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http://dx.doi.org/10.1093/neuonc/not079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3779037PMC
October 2013

Signaling pathway and molecular subgroups of medulloblastoma.

Int J Clin Exp Pathol 2013 15;6(7):1211-22. Epub 2013 Jun 15.

Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3693187PMC
February 2014

MIR-137 suppresses growth and invasion, is downregulated in oligodendroglial tumors and targets CSE1L.

Brain Pathol 2013 Jul 10;23(4):426-39. Epub 2013 Jan 10.

Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong.

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http://dx.doi.org/10.1111/bpa.12015DOI Listing
July 2013

MiR-383 is downregulated in medulloblastoma and targets peroxiredoxin 3 (PRDX3).

Brain Pathol 2013 Jul 9;23(4):413-25. Epub 2013 Jan 9.

Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong.

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http://dx.doi.org/10.1111/bpa.12014DOI Listing
July 2013

Quantitative assessment of gait and neurochemical correlation in a classical murine model of Parkinson's disease.

BMC Neurosci 2012 Nov 14;13:142. Epub 2012 Nov 14.

Research Center for Sectional and Imaging Anatomy, Shandong University School of Medicine, 250012 Jinan, Shandong, China.

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http://dx.doi.org/10.1186/1471-2202-13-142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507899PMC
November 2012

Overexpression of IL-7 enhances cisplatin resistance in glioma.

Cancer Biol Ther 2012 May 1;13(7):496-503. Epub 2012 May 1.

State Key Laboratory of Oncology in South China and Department of Neurosurgery/Neuro-oncology, Cancer Center Sun Yat-sen University, Guangzhou, China.

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http://dx.doi.org/10.4161/cbt.19592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364789PMC
May 2012

45 year old man with a pineal region tumor for over 15 years.

Brain Pathol 2012 Mar;22(2):255-8

Chinese University of Hong Kong Brain Tumor Centre, Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China.

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http://doi.wiley.com/10.1111/j.1750-3639.2012.00570.x
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March 2012

AluScan: a method for genome-wide scanning of sequence and structure variations in the human genome.

BMC Genomics 2011 Nov 17;12:564. Epub 2011 Nov 17.

Division of Life Science and Applied Genomics Centre, Hong Kong University of Science and Technology, 1 University Road, Clear Water Bay, Kowloon, Hong Kong, China.

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http://dx.doi.org/10.1186/1471-2164-12-564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3228862PMC
November 2011

Clinical significance of vasculogenic mimicry in human gliomas.

J Neurooncol 2011 Nov 30;105(2):173-9. Epub 2011 Apr 30.

State Key Laboratory of Oncology in South China and Department of Neurosurgery/Neuro-Oncology, Cancer Center, Sun Yat-sen University, 651 Dongfeng Road East, Guangzhou, 510060, People's Republic of China.

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http://link.springer.com/content/pdf/10.1007/s11060-011-0578
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http://link.springer.com/10.1007/s11060-011-0578-5
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http://dx.doi.org/10.1007/s11060-011-0578-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198193PMC
November 2011

Sirtuin 1 is upregulated in a subset of hepatocellular carcinomas where it is essential for telomere maintenance and tumor cell growth.

Cancer Res 2011 Jun 28;71(12):4138-49. Epub 2011 Apr 28.

The State Key Laboratory in Oncology in South China, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-4274DOI Listing
June 2011

Dyslexia-associated kiaa0319-like protein interacts with axon guidance receptor nogo receptor 1.

Cell Mol Neurobiol 2011 Jan 10;31(1):27-35. Epub 2010 Aug 10.

The Chinese University of Hong Kong, Shatin N.T., China.

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http://dx.doi.org/10.1007/s10571-010-9549-1DOI Listing
January 2011

Umbilical cord-derived mesenchymal stem cells with forced expression of hepatocyte growth factor enhance remyelination and functional recovery in a rat intracerebral hemorrhage model.

Neurosurgery 2010 Aug;67(2):357-65; discussion 365-6

Division of Neurosurgery, Department of Surgery, The Chinese University of Hong Kong, Shatin, Hong Kong.

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http://dx.doi.org/10.1227/01.NEU.0000371983.06278.B3DOI Listing
August 2010

Tyk2/STAT3 signaling mediates beta-amyloid-induced neuronal cell death: implications in Alzheimer's disease.

J Neurosci 2010 May;30(20):6873-81

Department of Biochemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.

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http://dx.doi.org/10.1523/JNEUROSCI.0519-10.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6632652PMC
May 2010

Association between temporal lobe P-glycoprotein expression and seizure recurrence after surgery for pharmacoresistant temporal lobe epilepsy.

Neurobiol Dis 2010 Aug 18;39(2):192-7. Epub 2010 Apr 18.

Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China.

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http://dx.doi.org/10.1016/j.nbd.2010.04.006DOI Listing
August 2010

Autophagy induced by valproic acid is associated with oxidative stress in glioma cell lines.

Neuro Oncol 2010 Apr 15;12(4):328-40. Epub 2009 Oct 15.

State Key Laboratory for Cancer Research in Southern China, Department of Neurosurgery/Neuro-Oncology, Cancer Center, Sun Yat-Sen University, Guangzhou, People's Republic of China.

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http://dx.doi.org/10.1093/neuonc/nop005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2940599PMC
April 2010

Role of the RARRES1 gene in nasopharyngeal carcinoma.

Cancer Genet Cytogenet 2009 Oct;194(1):58-64

Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, 30-32 Ngan Shing Street, Shatin, Hong Kong.

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http://dx.doi.org/10.1016/j.cancergencyto.2009.06.005DOI Listing
October 2009

Identification of a novel 12p13.3 amplicon in nasopharyngeal carcinoma.

J Pathol 2010 Jan;220(1):97-107

Department of Anatomical and Cellular Pathology, State Key Laboratory in Oncology in South China, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR.

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http://dx.doi.org/10.1002/path.2609DOI Listing
January 2010

Inflammatory pseudotumors of the central nervous system.

Hum Pathol 2009 Nov 5;40(11):1611-7. Epub 2009 Aug 5.

Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong.

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http://dx.doi.org/10.1016/j.humpath.2009.04.016DOI Listing
November 2009

Neurotrophism of bone marrow stromal cells to embryonic stem cells: noncontact induction and transplantation to a mouse ischemic stroke model.

Cell Transplant 2009 ;18(4):391-404

Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong; Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong.

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http://dx.doi.org/10.3727/096368909788809767DOI Listing
September 2009

Age distribution of human papillomavirus infection and cervical neoplasia reflects caveats of cervical screening policies.

Int J Cancer 2010 Jan;126(1):297-301

Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, People's Republic of China.

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http://dx.doi.org/10.1002/ijc.24731DOI Listing
January 2010

Glioblastoma stem cells resistant to temozolomide-induced autophagy.

Chin Med J (Engl) 2009 Jun;122(11):1255-9

State Key Laboratory for Cancer Research in Southern China and Department of Neurosurgery/Neuro-oncology, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong 510060, China.

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June 2009

New testing approach in HLA genotyping helps overcome barriers in effective clinical practice.

Clin Chem 2009 Aug 25;55(8):1568-72. Epub 2009 Jun 25.

Departments of Anatomical & Cellular Pathology and Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR.

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http://dx.doi.org/10.1373/clinchem.2009.127894DOI Listing
August 2009

Distribution of human papillomavirus types in cervical cancers in Hong Kong: current situation and changes over the last decades.

Int J Cancer 2009 Oct;125(7):1671-7

Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, People's Republic of China.

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http://dx.doi.org/10.1002/ijc.24495DOI Listing
October 2009

Gene-wide tagging study of association between ABCB1 polymorphisms and multidrug resistance in epilepsy in Han Chinese.

Pharmacogenomics 2009 May;10(5):723-32

Department of Medicine and Therapeutics, Prince of Wales Hospital, Shatin, Hong Kong, China.

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http://dx.doi.org/10.2217/pgs.09.32DOI Listing
May 2009

miR-124 is frequently down-regulated in medulloblastoma and is a negative regulator of SLC16A1.

Hum Pathol 2009 Sep 7;40(9):1234-43. Epub 2009 May 7.

Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Shatin, Hong Kong.

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http://dx.doi.org/10.1016/j.humpath.2009.02.003DOI Listing
September 2009

Low molecular weight Abeta induces collapse of endoplasmic reticulum.

Mol Cell Neurosci 2009 May 5;41(1):32-43. Epub 2009 Feb 5.

Laboratory of Neurodegenerative Diseases, Department of Anatomy, LKS Faculty of Medicine, The University of Hong Kong, L1-49, Laboratory Block, Faculty of Medicine Building, 21 Sassoon Road, Pokfulam, Hong Kong SAR, China.

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http://linkinghub.elsevier.com/retrieve/pii/S104474310900019
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http://dx.doi.org/10.1016/j.mcn.2009.01.006DOI Listing
May 2009

Oncogenic role of microRNAs in brain tumors.

Acta Neuropathol 2009 Jun 3;117(6):599-611. Epub 2009 Apr 3.

Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Shatin, Hong Kong.

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http://dx.doi.org/10.1007/s00401-009-0525-0DOI Listing
June 2009

A 33-year-old Chinese woman with a left frontal tumor.

Brain Pathol 2009 Apr;19(2):337-40

Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.1111/j.1750-3639.2009.00277.xDOI Listing
April 2009

TOP2A overexpression in hepatocellular carcinoma correlates with early age onset, shorter patients survival and chemoresistance.

Int J Cancer 2009 Feb;124(3):644-52

Department of Anatomical and Cellular Pathology, Li Ka-Shing Institute of Health Sciences, Chinese University of Hong Kong, Shatin, Hong Kong, China.

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http://dx.doi.org/10.1002/ijc.23968DOI Listing
February 2009