Hisashi Iwaasa

Hisashi Iwaasa

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Hisashi Iwaasa

Hisashi Iwaasa

Publications by authors named "Hisashi Iwaasa"

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Anatomical and histological profiling of orphan G-protein-coupled receptor expression in gastrointestinal tract of C57BL/6J mice.

Cell Tissue Res 2009 Nov 10;338(2):257-69. Epub 2009 Sep 10.

Departments of Metabolic Disorder Research, Tsukuba Research Institute, BANYU Pharmaceutical, Okubo 3, Tsukuba, Ibaraki 300-2611, Japan.

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http://dx.doi.org/10.1007/s00441-009-0859-xDOI Listing
November 2009

Discovery of novel phenethylpyridone derivatives as potent melanin-concentrating hormone 1 receptor antagonists.

Bioorg Med Chem Lett 2009 Sep 9;19(17):5186-90. Epub 2009 Jul 9.

Department of Medicinal Chemistry, Tsukuba Research Institute, Merck Research Laboratories, Banyu Pharmaceutical Co. Ltd, Okubo-3, Tsukuba, Ibaraki, Japan.

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http://dx.doi.org/10.1016/j.bmcl.2009.07.023DOI Listing
September 2009

Identification of positron emission tomography ligands for NPY Y5 receptors in the brain.

Bioorg Med Chem Lett 2009 Sep 25;19(18):5436-9. Epub 2009 Jul 25.

Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd, Okubo 3, Tsukuba 300-2611, Japan.

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http://dx.doi.org/10.1016/j.bmcl.2009.07.103DOI Listing
September 2009

Cloning and characterization of rabbit neuropeptide Y receptor subtypes.

Peptides 2009 Aug 27;30(8):1441-7. Epub 2009 May 27.

Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd., 3 Okubo, Tsukuba, Ibaraki 300-2611, Japan.

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http://dx.doi.org/10.1016/j.peptides.2009.05.020DOI Listing
August 2009

Synergistic interaction between neuropeptide Y1 and Y5 receptor pathways in regulation of energy homeostasis.

Eur J Pharmacol 2009 Aug 29;615(1-3):113-7. Epub 2009 May 29.

Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd., Okubo 3, Tsukuba 300-2611, Japan.

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http://dx.doi.org/10.1016/j.ejphar.2009.05.018DOI Listing
August 2009

Discovery of imidazo[1,2-a]pyridines as potent MCH1R antagonists.

Bioorg Med Chem Lett 2009 Aug 4;19(16):4589-93. Epub 2009 Jul 4.

Tsukuba Research Institute, Merck Research Laboratories, Banyu Pharmaceutical Co, Ltd, Okubo 3, Tsukuba, Ibaraki 300-2611, Japan.

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http://dx.doi.org/10.1016/j.bmcl.2009.06.101DOI Listing
August 2009

Discovery of novel spiro-piperidine derivatives as highly potent and selective melanin-concentrating hormone 1 receptor antagonists.

Bioorg Med Chem Lett 2009 Jun 9;19(11):3072-7. Epub 2009 Apr 9.

Department of Medicinal Chemistry, Tsukuba Research Institute, Merck Research Laboratories, Banyu Pharmaceutical Co, Ltd, Tsukuba, Ibaraki, Japan.

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http://dx.doi.org/10.1016/j.bmcl.2009.04.016DOI Listing
June 2009

Identification and characterization of a selective radioligand for melanin-concentrating hormone 1-receptor (MCH1R).

Bioorg Med Chem Lett 2009 May 26;19(10):2835-9. Epub 2009 Mar 26.

Department of Metabolic Disorder, Tsukuba Research Institute, BANYU Pharmaceutical Co., Ltd, Okubo, Ibaraki, Japan.

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http://dx.doi.org/10.1016/j.bmcl.2009.03.102DOI Listing
May 2009

Discovery of substituted 2,4,4-triarylimidazoline derivatives as potent and selective neuropeptide Y Y5 receptor antagonists.

Bioorg Med Chem Lett 2009 Mar 4;19(6):1670-4. Epub 2009 Feb 4.

Tsukuba Research Institute, Merck Research Laboratories, Banyu Pharmaceutical Company, Ltd, 3 Okubo, Tsukuba 300-2611, Japan.

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http://linkinghub.elsevier.com/retrieve/pii/S0960894X0900136
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http://dx.doi.org/10.1016/j.bmcl.2009.01.101DOI Listing
March 2009

Antagonism of central melanin-concentrating hormone 1 receptor alleviates steatohepatitis in mice.

J Endocrinol 2008 Aug 3;198(2):309-15. Epub 2008 Jun 3.

Tsukuba Research Institute Tsukuba Safety Assessment Laboratories, Banyu Pharmaceutical Co., Ltd, 3 Okubo, Tsukuba 300-2611, Japan.

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http://dx.doi.org/10.1677/JOE-08-0087DOI Listing
August 2008

RFamide peptide QRFP43 causes obesity with hyperphagia and reduced thermogenesis in mice.

Endocrinology 2006 Jun 16;147(6):2916-22. Epub 2006 Mar 16.

Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd., 3 Okubo, Tsukuba, Ibaraki 300-2611, Japan.

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http://dx.doi.org/10.1210/en.2005-1580DOI Listing
June 2006

Antiobesity effect of a melanin-concentrating hormone 1 receptor antagonist in diet-induced obese mice.

Endocrinology 2005 Jul 7;146(7):3080-6. Epub 2005 Apr 7.

Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd., Okubo 3, Tsukuba 300-2611, Japan.

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http://dx.doi.org/10.1210/en.2004-1150DOI Listing
July 2005

Characterization of the bombesin-like peptide receptor family in primates.

Genomics 2004 Jul;84(1):139-46

Department of Metabolic Disorders, Merck Research Laboratories, P.O. Box 2000, Rahway, NJ 07065, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S08887543040003
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http://dx.doi.org/10.1016/j.ygeno.2004.01.008DOI Listing
July 2004

N-acyl 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline: the first orexin-2 receptor selective non-peptidic antagonist.

Bioorg Med Chem Lett 2003 Dec;13(24):4497-9

Banyu Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd, Okubo 3, Tsukuba 300-2611, Ibaraki, Japan.

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http://dx.doi.org/10.1016/j.bmcl.2003.08.038DOI Listing
December 2003

Characterization of MCH-mediated obesity in mice.

Am J Physiol Endocrinol Metab 2003 May 28;284(5):E940-5. Epub 2003 Jan 28.

Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd., Okubo 3, Tsukuba 300-2611, Japan.

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http://dx.doi.org/10.1152/ajpendo.00529.2002DOI Listing
May 2003

Chronic intracerebroventricular infusion of MCH causes obesity in mice. Melanin-concentrating hormone.

Am J Physiol Endocrinol Metab 2003 Mar 26;284(3):E583-8. Epub 2002 Nov 26.

Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd., Okubo 3, Tsukuba 300 - 2611, Japan.

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http://dx.doi.org/10.1152/ajpendo.00350.2002DOI Listing
March 2003

Development of an orexin-2 receptor selective agonist, [Ala(11), D-Leu(15)]orexin-B.

Bioorg Med Chem Lett 2003 Jan;13(1):111-3

Banyu Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd., Okubo-3, Tsukuba 300-2611, Ibaraki, Japan.

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http://dx.doi.org/10.1016/s0960-894x(02)00851-xDOI Listing
January 2003