Hiroyuki Marusawa

Hiroyuki Marusawa

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Hiroyuki Marusawa

Publications by authors named "Hiroyuki Marusawa"

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100Publications

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Microsatellite instability and immune checkpoint inhibitors: toward precision medicine against gastrointestinal and hepatobiliary cancers.

J Gastroenterol 2019 Sep 7. Epub 2019 Sep 7.

Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, 5-30 Fudegasaki-cho, Tennoji-ku, Osaka, 5438555, Japan.

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http://dx.doi.org/10.1007/s00535-019-01620-7DOI Listing
September 2019

Comprehensive analysis of genetic aberrations linked to tumorigenesis in regenerative nodules of liver cirrhosis.

J Gastroenterol 2019 Jul 12;54(7):628-640. Epub 2019 Feb 12.

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.

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http://dx.doi.org/10.1007/s00535-019-01555-zDOI Listing
July 2019

Comparative proteomics of Helicobacter pylori strains reveals geographical features rather than genomic variations.

Genes Cells 2019 Feb 20;24(2):139-150. Epub 2019 Jan 20.

Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.

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http://dx.doi.org/10.1111/gtc.12662DOI Listing
February 2019

Ultrasound-guided microfoam sclerotherapy with polidocanol for symptomatic giant hepatic cyst: Initial experience.

Hepatol Res 2018 Nov 10;48(12):1055-1063. Epub 2018 Jul 10.

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

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http://dx.doi.org/10.1111/hepr.13202DOI Listing
November 2018

Genetic features of multicentric/multifocal intramucosal gastric carcinoma.

Int J Cancer 2018 10 3;143(8):1923-1934. Epub 2018 Jul 3.

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

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http://dx.doi.org/10.1002/ijc.31578DOI Listing
October 2018

The use of hepatitis B immunoglobulin with or without hepatitis B vaccine to prevent de novo hepatitis B in pediatric recipients of anti-HBc-positive livers.

Pediatr Transplant 2018 08 15;22(5):e13227. Epub 2018 May 15.

Organ Transplantation Unit, Kyoto University Hospital, Kyoto University Graduate School of Medicine, Kyoto, Japan.

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http://dx.doi.org/10.1111/petr.13227DOI Listing
August 2018

Novel approaches for molecular targeted therapy against hepatocellular carcinoma.

Hepatol Res 2018 Jul 17;48(8):597-607. Epub 2018 May 17.

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

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http://dx.doi.org/10.1111/hepr.13181DOI Listing
July 2018

Association of Mac-2-binding protein glycosylation isomer level with nutritional status in chronic liver disease.

J Gastroenterol Hepatol 2018 Feb 22. Epub 2018 Feb 22.

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

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http://dx.doi.org/10.1111/jgh.14130DOI Listing
February 2018

Proliferating EpCAM-Positive Ductal Cells in the Inflamed Liver Give Rise to Hepatocellular Carcinoma.

Cancer Res 2017 11 26;77(22):6131-6143. Epub 2017 Sep 26.

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-1800DOI Listing
November 2017

Hepatitis C Treatment with Sofosbuvir and Ledipasvir Accompanied by Immediate Improvement in Hemoglobin A1c.

Digestion 2017 11 30;96(4):228-230. Epub 2017 Oct 30.

Department of Gastroenterology and Hepatology, Kyoto Katsura Hospital, Kyoto, Japan.

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http://dx.doi.org/10.1159/000484237DOI Listing
November 2017

Helicobacter pylori-Mediated Genetic Instability and Gastric Carcinogenesis.

Curr Top Microbiol Immunol 2017;400:305-323

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Kawara-Cho, Shogoin, Sakyo-Ku, Kyoto, 606-8507, Japan.

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http://dx.doi.org/10.1007/978-3-319-50520-6_13DOI Listing
June 2017

Activation of TNF-α-AID axis and co-inhibitory signals in coordination with Th1-type immunity in a mouse model recapitulating hepatitis B.

Antiviral Res 2017 Mar 5;139:138-145. Epub 2017 Jan 5.

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.antiviral.2017.01.004DOI Listing
March 2017

Genetic basis of hepatitis virus-associated hepatocellular carcinoma: linkage between infection, inflammation, and tumorigenesis.

J Gastroenterol 2017 Jan 6;52(1):26-38. Epub 2016 Oct 6.

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan.

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http://dx.doi.org/10.1007/s00535-016-1273-2DOI Listing
January 2017

Sonazoid-enhanced ultrasonography guidance improves the quality of pathological diagnosis in the biopsy of focal hepatic lesions.

Eur J Gastroenterol Hepatol 2016 Dec;28(12):1462-1467

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

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http://dx.doi.org/10.1097/MEG.0000000000000745DOI Listing
December 2016

MSH2 Dysregulation Is Triggered by Proinflammatory Cytokine Stimulation and Is Associated with Liver Cancer Development.

Cancer Res 2016 08 3;76(15):4383-93. Epub 2016 Jun 3.

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-2926DOI Listing
August 2016

Long-term efficacy of hepatitis B vaccination as post-transplant prophylaxis in hepatitis B surface antigen (HBsAg) positive recipients and HBsAg negative recipients of anti-hepatitis B core positive grafts.

Hepatol Res 2016 May 8;46(6):541-51. Epub 2015 Oct 8.

Department of Hepato-Biliary-Pancreatic Surgery and Transplantation, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

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http://dx.doi.org/10.1111/hepr.12586DOI Listing
May 2016

[Treatment for hepatitis C before and after liver transplantation].

Nihon Rinsho 2015 Dec;73 Suppl 9:306-10

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December 2015

Molecular Pathogenesis of Helicobacter pylori-Related Gastric Cancer.

Gastroenterol Clin North Am 2015 Sep 7;44(3):625-38. Epub 2015 Jul 7.

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Kawara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.gtc.2015.05.011DOI Listing
September 2015

Hepatic inflammation facilitates transcription-associated mutagenesis via AID activity and enhances liver tumorigenesis.

Carcinogenesis 2015 Aug 12;36(8):904-13. Epub 2015 May 12.

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Kawara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan

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http://dx.doi.org/10.1093/carcin/bgv065DOI Listing
August 2015

Exploring the Mechanisms of Gastrointestinal Cancer Development Using Deep Sequencing Analysis.

Cancers (Basel) 2015 Jun 15;7(2):1037-51. Epub 2015 Jun 15.

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan.

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http://dx.doi.org/10.3390/cancers7020823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491698PMC
June 2015

Comprehensive characterization of hepatitis B virus-associated multifocal hepatocellular carcinoma using a multi-omics strategy.

Ann Transl Med 2015 Jan;3(1)

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

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http://dx.doi.org/10.3978/j.issn.2305-5839.2014.12.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293482PMC
January 2015

MicroRNA-33 regulates sterol regulatory element-binding protein 1 expression in mice.

Nat Commun 2013 ;4:2883

1] Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan [2] Department of Clinical Innovative Medicine, Institute for Advancement of Clinical and Translational Science, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan [3].

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http://dx.doi.org/10.1038/ncomms3883DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863899PMC
October 2014

Reactivation from occult HBV carrier status is characterized by low genetic heterogeneity with the wild-type or G1896A variant prevalence.

J Hepatol 2014 Sep 4;61(3):492-501. Epub 2014 May 4.

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2014.04.033DOI Listing
September 2014

The RNA-editing enzyme APOBEC1 requires heterogeneous nuclear ribonucleoprotein Q isoform 6 for efficient interaction with interleukin-8 mRNA.

J Biol Chem 2014 Sep 6;289(38):26226-38. Epub 2014 Aug 6.

From the Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine, 1-7-1, Kohnodai, Ichikawa, Chiba 272-8516, Japan.

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http://dx.doi.org/10.1074/jbc.M114.563221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176254PMC
September 2014

Novel mouse models of hepatocarcinogenesis with stepwise accumulation of genetic alterations.

Dig Dis 2013 21;31(5-6):454-8. Epub 2013 Nov 21.

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

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http://dx.doi.org/10.1159/000355244DOI Listing
August 2014

Accumulation of somatic mutations in TP53 in gastric epithelium with Helicobacter pylori infection.

Gastroenterology 2014 Aug 29;147(2):407-17.e3. Epub 2014 Apr 29.

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

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http://dx.doi.org/10.1053/j.gastro.2014.04.036DOI Listing
August 2014

Inflammation and gastrointestinal cancer: an overview.

Cancer Lett 2014 Apr 24;345(2):153-6. Epub 2013 Aug 24.

Centre for Innate Immunity and Infectious Diseases, Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2013.08.025DOI Listing
April 2014

Mouse models of hepatitis B virus infection comprising host-virus immunologic interactions.

Pathogens 2014 Apr 23;3(2):377-89. Epub 2014 Apr 23.

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto 606-8103, Japan.

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http://dx.doi.org/10.3390/pathogens3020377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243451PMC
April 2014

Enhanced expression of activation-induced cytidine deaminase in human gastric mucosa infected by Helicobacter pylori and its decrease following eradication.

J Gastroenterol 2014 Mar 18;49(3):427-35. Epub 2013 Apr 18.

Department of Gastroenterology and Hepatology, National Center for Global Health and Medicine (NCGM), 1-21-1 Toyama, Shinjuku-ku, Tokyo, 162-8655, Japan,

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http://dx.doi.org/10.1007/s00535-013-0808-zDOI Listing
March 2014

A model of liver carcinogenesis originating from hepatic progenitor cells with accumulation of genetic alterations.

Int J Cancer 2014 Mar 16;134(5):1067-76. Epub 2013 Sep 16.

Department of Gastroenterology and Hepatology, Graduate School of MedicineKyoto University, Kyoto, Japan.

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http://dx.doi.org/10.1002/ijc.28445DOI Listing
March 2014

Chronic rejection associated with antiviral therapy for recurrent hepatitis C after living-donor liver transplantation.

Transplantation 2014 Feb;97(3):344-50

1 Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan. 2 Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan. 3 Department of Diagnostic Pathology, Graduate School of Medicine, Kyoto University, Kyoto, Japan. 4 Address correspondence to: Yoshihide Ueda, M.D., Ph.D., Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/01.TP.0000435702.61642.0aDOI Listing
February 2014

Characteristics of hepatocellular carcinoma with stem/progenitor cell phenotypes.

Gastroenterology 2014 Feb 17;146(2):579-81. Epub 2013 Dec 17.

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

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http://dx.doi.org/10.1053/j.gastro.2013.12.009DOI Listing
February 2014

Leptin receptor somatic mutations are frequent in HCV-infected cirrhotic liver and associated with hepatocellular carcinoma.

Gastroenterology 2014 Jan 19;146(1):222-32.e35. Epub 2013 Sep 19.

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2013.09.025DOI Listing
January 2014

Landscape of genetic aberrations detected in human colorectal cancers.

Gastroenterology 2013 Sep 25;145(3):686-8. Epub 2013 Jul 25.

Department of Gastroenterology and Hepatology, Kyoto University, Kyoto, Japan.

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http://dx.doi.org/10.1053/j.gastro.2013.07.029DOI Listing
September 2013

Platelet plays a role in the pathogenesis of hepatitis B virus-related hepatocellular carcinoma.

Gastroenterology 2013 May 22;144(5):1140-2. Epub 2013 Mar 22.

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

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http://dx.doi.org/10.1053/j.gastro.2013.03.034DOI Listing
May 2013

Recurrent somatic mutations in human gastric cancers identified by whole exome sequencing.

Gastroenterology 2012 Nov 21;143(5):1385-1387. Epub 2012 Sep 21.

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

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http://dx.doi.org/10.1053/j.gastro.2012.09.027DOI Listing
November 2012

[Chronic inflammation and gastric cancer development].

Nihon Rinsho 2012 Oct;70(10):1694-8

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University.

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October 2012

Inflammation-associated cancer development in digestive organs: mechanisms and roles for genetic and epigenetic modulation.

Gastroenterology 2012 Sep 13;143(3):550-563. Epub 2012 Jul 13.

Division of Epigenomics, National Cancer Center Research Institute, Tokyo, Japan.

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http://dx.doi.org/10.1053/j.gastro.2012.07.009DOI Listing
September 2012

Inflammation-mediated genomic instability: roles of activation-induced cytidine deaminase in carcinogenesis.

Cancer Sci 2012 Jul 11;103(7):1201-6. Epub 2012 May 11.

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

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http://dx.doi.org/10.1111/j.1349-7006.2012.02293.xDOI Listing
July 2012

Clinical characteristics of non-B non-C hepatocellular carcinoma: a single-center retrospective study.

Digestion 2011 2;84 Suppl 1:43-9. Epub 2011 Dec 2.

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

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http://dx.doi.org/10.1159/000333212DOI Listing
May 2012

Excessive activity of apolipoprotein B mRNA editing enzyme catalytic polypeptide 2 (APOBEC2) contributes to liver and lung tumorigenesis.

Int J Cancer 2012 Mar 30;130(6):1294-301. Epub 2011 May 30.

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Shogoin, Sakyo-Ku, Kyoto, Japan.

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http://dx.doi.org/10.1002/ijc.26114DOI Listing
March 2012

[Genetic alterations leading to the development of colitis-associated colorectal cancers].

Nihon Rinsho 2012 Feb;70 Suppl 1:651-5

Department of Gastroenterology School of Medicine, Kyoto University.

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February 2012

Role of activation-induced cytidine deaminase in inflammation-associated cancer development.

Adv Immunol 2011 ;111:109-41

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

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http://dx.doi.org/10.1016/B978-0-12-385991-4.00003-9DOI Listing
January 2012

Large-scale identification of effector genes that mediate the type I interferon antiviral response.

Gastroenterology 2012 Jan 19;142(1):178-80. Epub 2011 Nov 19.

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

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http://dx.doi.org/10.1053/j.gastro.2011.11.008DOI Listing
January 2012

De novo activation of HBV with escape mutations from hepatitis B surface antibody after living donor liver transplantation.

Antivir Ther 2011 ;16(4):479-87

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

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http://dx.doi.org/10.3851/IMP1771DOI Listing
October 2011

[Role of inflammation in the development of gastrointestinal cancers].

Nihon Shokakibyo Gakkai Zasshi 2011 Aug;108(8):1374-82

Department of Gastroenterology and Hepatology, Kyoto University, Graduate School of Medicine.

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August 2011

[The cutting-edge of medicine; inflammation and development of gastrointestinal cancers].

Nihon Naika Gakkai Zasshi 2011 Aug;100(8):2269-74

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Japan.

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http://dx.doi.org/10.2169/naika.100.2269DOI Listing
August 2011

Acquisition of Genetic Aberrations by Activation-Induced Cytidine Deaminase (AID) during Inflammation-Associated Carcinogenesis.

Cancers (Basel) 2011 Jun 22;3(2):2750-66. Epub 2011 Jun 22.

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan.

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http://dx.doi.org/10.3390/cancers3022750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757441PMC
June 2011

A marker for dormant cancer stem cells in human hepatocellular carcinoma.

Gastroenterology 2011 Apr 24;140(4):1353-5; discussion 1355. Epub 2011 Feb 24.

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

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http://dx.doi.org/10.1053/j.gastro.2011.02.039DOI Listing
April 2011

Involvement of activation-induced cytidine deaminase in the development of colitis-associated colorectal cancers.

J Gastroenterol 2011 Jan 28;46 Suppl 1:6-10. Epub 2010 Sep 28.

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Kawara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan.

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http://dx.doi.org/10.1007/s00535-010-0326-1DOI Listing
January 2011

Up-regulation of activation-induced cytidine deaminase causes genetic aberrations at the CDKN2b-CDKN2a in gastric cancer.

Gastroenterology 2010 Dec 14;139(6):1984-94. Epub 2010 Jul 14.

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

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http://dx.doi.org/10.1053/j.gastro.2010.07.010DOI Listing
December 2010

Individualized extension of pegylated interferon plus ribavirin therapy for recurrent hepatitis C genotype 1b after living-donor liver transplantation.

Transplantation 2010 Sep;90(6):661-5

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Shogoin, Sakyo-ku, Kyoto, Japan.

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http://dx.doi.org/10.1097/TP.0b013e3181d2bfcaDOI Listing
September 2010

Image of the month. Diaphragm-like stricture of the small intestine related to cytomegalovirus infection.

Clin Gastroenterol Hepatol 2010 Sep 1;8(9):A21. Epub 2010 Feb 1.

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

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http://dx.doi.org/10.1016/j.cgh.2010.01.012DOI Listing
September 2010

Helicobacter pylori-induced activation-induced cytidine deaminase expression and carcinogenesis.

Curr Opin Immunol 2010 Aug;22(4):442-7

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Kawara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.

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http://dx.doi.org/10.1016/j.coi.2010.06.001DOI Listing
August 2010

Pneumothorax following esophageal perforation due to ingested fish bone.

Clin Gastroenterol Hepatol 2010 May 7;8(5):A24. Epub 2009 Aug 7.

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

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http://dx.doi.org/10.1016/j.cgh.2009.07.030DOI Listing
May 2010

[Mechanisms of H. pylori infection-induced gastric carcinogenesis].

Gan To Kagaku Ryoho 2010 Jan;37(1):23-7

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

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January 2010

Acute Epstein-Barr virus infection presenting as severe gastroenteritis without infectious mononucleosis-like manifestations.

Clin J Gastroenterol 2009 Dec 6;2(6):398-403. Epub 2009 Oct 6.

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Shogoinkawaharacho, Sakyo-ku, Kyoto, 606-8507, Japan.

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http://link.springer.com/10.1007/s12328-009-0114-8
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http://dx.doi.org/10.1007/s12328-009-0114-8DOI Listing
December 2009

[A novel mechanism for H. pylori-induced cell damage--induction of gene mutation by AID].

Nihon Rinsho 2009 Dec;67(12):2265-70

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University.

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December 2009

Attenuation of proteolysis-mediated cyclin E regulation by alternatively spliced Parkin in human colorectal cancers.

Int J Cancer 2009 Nov;125(9):2029-35

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

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http://dx.doi.org/10.1002/ijc.24565DOI Listing
November 2009

A novel mechanism for inflammation-associated carcinogenesis; an important role of activation-induced cytidine deaminase (AID) in mutation induction.

J Mol Med (Berl) 2009 Oct;87(10):1023-7

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Sakyo, Kyoto, Japan.

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http://link.springer.com/10.1007/s00109-009-0527-3
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http://dx.doi.org/10.1007/s00109-009-0527-3DOI Listing
October 2009

Organ-specific profiles of genetic changes in cancers caused by activation-induced cytidine deaminase expression.

Int J Cancer 2008 Dec;123(12):2735-40

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

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http://dx.doi.org/10.1002/ijc.23853DOI Listing
December 2008

Translational research on HGF: A phase I/II study of recombinant human HGF for the treatment of fulminant hepatic failure.

Hepatol Res 2008 Nov;38 Suppl 1:S88-92

Digestive and Life-style Related Diseases, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.

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http://dx.doi.org/10.1111/j.1872-034X.2008.00432.xDOI Listing
November 2008

Activation-induced cytidine deaminase links between inflammation and the development of colitis-associated colorectal cancers.

Gastroenterology 2008 Sep 18;135(3):889-98, 898.e1-3. Epub 2008 Jul 18.

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

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http://dx.doi.org/10.1053/j.gastro.2008.06.091DOI Listing
September 2008

Mechanism for gastric cancer development by Helicobacter pylori infection.

J Gastroenterol Hepatol 2008 Aug 10;23(8 Pt 1):1175-81. Epub 2008 Jun 10.

Department of Gastroenterology and Hepatology, Kyoto University, Kyoto, Japan.

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http://doi.wiley.com/10.1111/j.1440-1746.2008.05472.x
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http://dx.doi.org/10.1111/j.1440-1746.2008.05472.xDOI Listing
August 2008

Aberrant AID expression and human cancer development.

Int J Biochem Cell Biol 2008 25;40(8):1399-402. Epub 2008 Jan 25.

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Kawara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.

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http://dx.doi.org/10.1016/j.biocel.2008.01.018DOI Listing
July 2008

Activation-induced cytidine deaminase links bile duct inflammation to human cholangiocarcinoma.

Hepatology 2008 Mar;47(3):888-96

Department of Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.

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http://dx.doi.org/10.1002/hep.22125DOI Listing
March 2008

Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium.

Nat Med 2007 Apr 1;13(4):470-6. Epub 2007 Apr 1.

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.

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http://dx.doi.org/10.1038/nm1566DOI Listing
April 2007

Spontaneous rupture of intrahepatic aneurysm.

Clin Gastroenterol Hepatol 2007 Apr;5(4):A30

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

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http://dx.doi.org/10.1016/j.cgh.2007.01.012DOI Listing
April 2007

Expression of activation-induced cytidine deaminase in human hepatocytes during hepatocarcinogenesis.

Int J Cancer 2007 Feb;120(3):469-76

Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

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http://dx.doi.org/10.1002/ijc.22292DOI Listing
February 2007

Growth and differentiation of colony-forming human hepatocytes in vitro.

J Hepatol 2006 Apr 13;44(4):749-57. Epub 2005 Dec 13.

Yoshizato Project, Cooperative Link of Unique Science and Technology for Economy Revitalization , CLUSTER, Hiroshima Prefectural Institute of Industrial Science and Technology, Hiroshima 739-0046, Japan.

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http://dx.doi.org/10.1016/j.jhep.2005.10.028DOI Listing
April 2006

Anti-viral protein APOBEC3G is induced by interferon-alpha stimulation in human hepatocytes.

Biochem Biophys Res Commun 2006 Mar 10;341(2):314-9. Epub 2006 Jan 10.

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2005.12.192DOI Listing
March 2006

Expression of APOBEC2 is transcriptionally regulated by NF-kappaB in human hepatocytes.

FEBS Lett 2006 Feb 3;580(3):731-5. Epub 2006 Jan 3.

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Shogoin, Kyoto 606-8507, Japan.

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http://dx.doi.org/10.1016/j.febslet.2005.12.081DOI Listing
February 2006

Host factors are important in determining clinical outcomes of Helicobacter pylori infection.

J Gastroenterol 2006 Jan;41(1):1-9

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kawahara-cho 54, Shogoin, Sakyo, Kyoto, 606-8507, Japan.

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http://dx.doi.org/10.1007/s00535-005-1743-4DOI Listing
January 2006