Hiroyuki Hanzawa

Hiroyuki Hanzawa

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Hiroyuki Hanzawa

Hiroyuki Hanzawa

Publications by authors named "Hiroyuki Hanzawa"

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18Publications

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A novel inhibitor stabilizes the inactive conformation of MAPK-interacting kinase 1.

Acta Crystallogr F Struct Biol Commun 2018 Mar 26;74(Pt 3):156-160. Epub 2018 Feb 26.

R&D Division, Daiichi Sankyo Co. Ltd, 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.

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http://dx.doi.org/10.1107/S2053230X18002108DOI Listing
March 2018

Discovery and structure-guided fragment-linking of 4-(2,3-dichlorobenzoyl)-1-methyl-pyrrole-2-carboxamide as a pyruvate kinase M2 activator.

Bioorg Med Chem 2017 07 5;25(13):3540-3546. Epub 2017 May 5.

Daiichi Sankyo RD Novare Co., Ltd., 1-16-13, Kita-Kasai, Edogawa-ku, Tokyo 134-8630, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2017.05.004DOI Listing
July 2017

Improvement of Ligand Affinity and Thermodynamic Properties by NMR-Based Evaluation of Local Dynamics and Surface Complementarity in the Receptor-Bound State.

Angew Chem Int Ed Engl 2016 11 20;55(47):14606-14609. Epub 2016 Oct 20.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-0033, Japan.

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http://dx.doi.org/10.1002/anie.201607474DOI Listing
November 2016

Discovery and structure-guided optimization of tert-butyl 6-(phenoxymethyl)-3-(trifluoromethyl)benzoates as liver X receptor agonists.

Bioorg Med Chem Lett 2015 Sep 23;25(18):3914-20. Epub 2015 Jul 23.

R&D Division, Daiichi Sankyo Co., Ltd, 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2015.07.047DOI Listing
September 2015

Suppression of problematic compound oligomerization by cosolubilization of nondetergent sulfobetaines.

ChemMedChem 2015 Apr 11;10(4):736-41. Epub 2015 Mar 11.

Biomedicinal Information Research Center (BIRC) and Molecular Profiling Research Center (Molprof), National Institute of Advanced Industrial Science and Technology (AIST), 2-3-26 Aomi, Koto-ku, Tokyo 135-0064 (Japan); Japan Biological Informatics Consortium (JBIC), 2-3-26 Aomi, Koto-ku, Tokyo 135-0064 (Japan).

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http://dx.doi.org/10.1002/cmdc.201500057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471626PMC
April 2015

Reassessment of the unique mode of binding between angiotensin II type 1 receptor and their blockers.

PLoS One 2013 8;8(11):e79914. Epub 2013 Nov 8.

Department of Cardiology, Fukuoka University School of Medicine, Fukuoka City, Fukuoka, Japan ; Department of Molecular Cardiovascular Therapeutics, Fukuoka University School of Medicine, Fukuoka City, Fukuoka, Japan ; Department of Molecular Cardiology, Cleveland Clinic Foundation, Cleveland, Ohio, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0079914PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832659PMC
July 2014

An accurate pharmacophore mapping method by NMR spectroscopy.

Angew Chem Int Ed Engl 2012 Feb 30;51(6):1362-5. Epub 2011 Dec 30.

Biomedicinal Information Research Center (BIRC), National Institute of Advanced Industrial Science and Technology (AIST), Japan.

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http://dx.doi.org/10.1002/anie.201104905DOI Listing
February 2012

[NMR screening in fragment-based drug discovery].

Yakugaku Zasshi 2010 Mar;130(3):325-33

Exploratory Research Laboratories I, Daiichi Sankyo Co., Ltd, Japan.

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http://dx.doi.org/10.1248/yakushi.130.325DOI Listing
March 2010

[NMR in the fragment-based drug discovery].

Tanpakushitsu Kakusan Koso 2009 Sep;54(12 Suppl):1617-21

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September 2009

Novel binding mode of the acidic CYP2D6 substrates pactimibe and its metabolite R-125528.

Drug Metab Dispos 2008 Sep 4;36(9):1938-43. Epub 2008 Jun 4.

Drug Metabolism and Pharmacokinetics Research Laboratories, Daiichi-Sankyo Co, Ltd, Tokyo, Japan.

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http://dx.doi.org/10.1124/dmd.108.020776DOI Listing
September 2008

Molecular mechanism underlying inverse agonist of angiotensin II type 1 receptor.

J Biol Chem 2006 Jul 10;281(28):19288-95. Epub 2006 May 10.

Department of Cardiology, Fukuoka University School of Medicine, Fukuoka 814-0180, Japan.

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http://dx.doi.org/10.1074/jbc.M602144200DOI Listing
July 2006