Publications



Accurate quantitation of choline and ethanolamine plasmalogen molecular species in human plasma by liquid chromatography-tandem mass spectrometry.
J Pharm Biomed Anal 2017 Feb 15;134:77-85. Epub 2016 Nov 15.
Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555, Japan. Electronic address:

In vivo visualization of tau deposits in corticobasal syndrome by 18F-THK5351 PET.
Neurology 2016 Nov 28;87(22):2309-2316. Epub 2016 Oct 28.
From the Departments of Neurology (A.K., T.H., T.B., N.S., R.O., S.Y., J.K., M.E., M.A.), Pharmacology (N.O., R.H., K.Y.), and Diagnostic Radiology (S.M.), Tohoku University Graduate School of Medicine; Divisions of Cyclotron Nuclear Medicine (S.W., K.H., M.T.) and Radiopharmaceutical Chemistry (Y.F., R.I., S.F.), Cyclotron and Radioisotope Center, and Department of Geriatric and Respiratory Medicine (A.I., K.F., H.A.) and Division of Neuroimaging (Y.K.), Institute of Development, Aging and Cancer, Tohoku University; Department of Neurology (M.K.), Tohoku Pharmaceutical University Hospital; Department of Neurology (O.T.), Sendai Medical Center; and Department of Neurology (A.T.), National Hospital Organization, Sendai Nishitaga Hospital, Sendai, Japan.




Lysophosphatidylcholine acyltransferase 1 protects against cytotoxicity induced by polyunsaturated fatty acids.
FASEB J 2016 May 17;30(5):2027-39. Epub 2016 Feb 17.
Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan Japan Agency for Medical Research and Development-Core Research for Evolutionary Science and Technology (AMED-CREST), Tokyo, Japan

Differential effects of docoosahexaenoic and arachidonic acid on fatty acid composition and myosin heavy chain-related genes of slow- and fast-twitch skeletal muscle tissues.
Mol Cell Biochem 2016 Apr 28;415(1-2):169-81. Epub 2016 Mar 28.
Department of Environmental Physiology, Faculty of Medicine, Shimane University, 89-1 Enya-cho, Izumo, Shimane, 693-8501, Japan.

18F-THK5351: A Novel PET Radiotracer for Imaging Neurofibrillary Pathology in Alzheimer Disease.
J Nucl Med 2016 Feb 5;57(2):208-14. Epub 2015 Nov 5.
Division of Neuro-imaging, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan Division of Radiopharmaceutical Chemistry, Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan.

Maternal dietary imbalance between omega-6 and omega-3 polyunsaturated fatty acids impairs neocortical development via epoxy metabolites.
Stem Cells 2016 Feb 27;34(2):470-82. Epub 2015 Nov 27.
Department of Developmental Neuroscience, Center for Neuroscience, United Centers for Advanced Research and Translational Medicine, Tohoku University School of Medicine, Miyagi, Japan.




Glial fibrillar acidic protein in the cerebrospinal fluid of Alzheimer's disease, dementia with Lewy bodies, and frontotemporal lobar degeneration.
J Neurochem 2016 Jan 11;136(2):258-61. Epub 2015 Nov 11.
Department of Geriatrics and Gerontology, Division of Brain Sciences, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.


Lysophosphatidylcholine promotes SREBP-2 activation via rapid cholesterol efflux and SREBP-2-independent cytokine release in human endothelial cells.
J Biochem 2015 Oct 21;158(4):331-8. Epub 2015 May 21.
Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, Kyoto 610-0321, Japan; and

Neurite outgrowth stimulation by n-3 and n-6 PUFAs of phospholipids in apoE-containing lipoproteins secreted from glial cells.
J Lipid Res 2015 Oct 3;56(10):1880-90. Epub 2015 Aug 3.
Division of Applied Life Sciences, Kyoto University Graduate School of Agriculture, Kyoto 606-8502, Japan Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Kyoto 606-8502, Japan.

Longitudinal Assessment of Tau Pathology in Patients with Alzheimer's Disease Using [18F]THK-5117 Positron Emission Tomography.
PLoS One 2015 13;10(10):e0140311. Epub 2015 Oct 13.
Department of Geriatrics and Gerontology, Institute of Development, Aging and Cancer, Tohoku University, Sendai city, Miyagi prefecture, Japan.


Amyloid deposits and response to shunt surgery in idiopathic normal-pressure hydrocephalus.
J Neurol Sci 2015 Sep 16;356(1-2):124-8. Epub 2015 Jun 16.
Division of Cyclotron Nuclear Medicine, Cyclotron and Radioisotope Center, Tohoku University, 6-3, Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan; Department of Pharmacology, Tohoku University Graduate School of Medicine, 2-1, Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.

Transport of the cholera toxin B-subunit from recycling endosomes to the Golgi requires clathrin and AP-1.
J Cell Sci 2015 Aug 1;128(16):3131-42. Epub 2015 Jul 1.
Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan Pathological Cell Biology Laboratory, Graduate School of Pharmaceutical Sciences, University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan


Dietary ω3 fatty acid exerts anti-allergic effect through the conversion to 17,18-epoxyeicosatetraenoic acid in the gut.
Sci Rep 2015 Jun 11;5:9750. Epub 2015 Jun 11.
1] Division of Mucosal Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan [2] International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan [3] Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo 102-0075, Japan [4] Department of Medical Genome Science, Graduate School of Frontier Science, The University of Tokyo, Chiba 277-8562, Japan [5] Department of Medical Genome Science, Graduate School of Frontier Science, The University of Tokyo, Chiba 277-8562, Japan [6] Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan [7] Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.

Transport through recycling endosomes requires EHD1 recruitment by a phosphatidylserine translocase.
EMBO J 2015 Mar 16;34(5):669-88. Epub 2015 Jan 16.
Department of Health Chemistry, Graduate School of Pharmaceutical Sciences University of Tokyo, Tokyo, Japan Pathological Cell Biology Laboratory, Graduate School of Pharmaceutical Sciences University of Tokyo, Tokyo, Japan

ABCB4 exports phosphatidylcholine in a sphingomyelin-dependent manner.
J Lipid Res 2015 Mar 19;56(3):644-52. Epub 2015 Jan 19.
Institute for integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Kyoto 606-8502, Japan Laboratory of Cellular Biochemistry, Division of Applied Life Sciences, Kyoto University Graduate School of Agriculture, Kyoto 606-8502, Japan.


Visualization of the heterogeneous membrane distribution of sphingomyelin associated with cytokinesis, cell polarity, and sphingolipidosis.
FASEB J 2015 Feb 11;29(2):477-93. Epub 2014 Nov 11.
*Lipid Biology Laboratory, RIKEN, Hirosawa, Wako-shi, Saitama, Japan; INSERM U1060-Université Lyon, Villeurbanne, France; Institute for Molecular Bioscience and Centre for Microscopy and Microanalysis, University of Queensland, St. Lucia, Queensland, Australia; Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan; National Institute of Chemistry, Ljubljana, Slovenia; and Department of Biology, Biotechnical Faculty, University of Ljubljana, Ljubljana, Slovenia

Cortical laminar binding of PET amyloid and tau tracers in Alzheimer disease.
J Nucl Med 2015 Feb 8;56(2):270-3. Epub 2015 Jan 8.
Center for Brain Health, New York University, New York, New York The Steven and Alexandra Cohen Veterans Center at NYU, New York, New York

Identification of 14,20-dihydroxy-docosahexaenoic acid as a novel anti-inflammatory metabolite.
J Biochem 2014 Dec 9;156(6):315-21. Epub 2014 Jul 9.
Department of Health Chemistry; Business-Academia Collaborative Laboratory, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033; Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045; Department of Integral Analytical Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033; and PRESTO, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan Department of Health Chemistry; Business-Academia Collaborative Laboratory, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033; Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045; Department of Integral Analytical Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033; and PRESTO, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan Department of Health Chemistry; Business-Academia Collaborative Laboratory, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033; Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045; Department of Integral Analytical Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033; and PRESTO, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan


Eosinophils control the resolution of inflammation and draining lymph node hypertrophy through the proresolving mediators and CXCL13 pathway in mice.
FASEB J 2014 Sep 2;28(9):4036-43. Epub 2014 Jun 2.
Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, the University of Tokyo, Tokyo, Japan; Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan; Precursory Research for Embryonic Science and Technology (PRESTO), Japanese Science and Technology Agency, Saitama, Japan;



Image quality of grating target in model eye when viewed through a small-aperture corneal inlay.
J Cataract Refract Surg 2014 Jul;40(7):1182-91
From the Kyorin Eye Center (Inoue, Hirakata), Kyorin University School of Medicine, the Department of Ophthalmology (Inoue, Bissen-Miyajima), Tokyo Dental College Suidobashi Hospital, the Department of Ophthalmology (Noda), National Hospital Organization Tokyo Medical Center, Tokyo, the Minatomirai Eye Clinic (Arai), Yokohama, and the Department of Medical System Engineering (Ohnuma), Faculty of Engineering, Chiba University, Chiba, Japan.

18-HEPE, an n-3 fatty acid metabolite released by macrophages, prevents pressure overload-induced maladaptive cardiac remodeling.
J Exp Med 2014 Jul 21;211(8):1673-87. Epub 2014 Jul 21.
Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, the University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan PRESTO, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan



Sequential breakdown of 3-phosphorylated phosphoinositides is essential for the completion of macropinocytosis.
Proc Natl Acad Sci U S A 2014 Mar 3;111(11):E978-87. Epub 2014 Mar 3.
Department of Health Chemistry and Pathological Cell Biology Laboratory, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo 113-0033, Japan.

Coffee treatment prevents the progression of sarcopenia in aged mice in vivo and in vitro.
Exp Gerontol 2014 Feb 22;50:1-8. Epub 2013 Nov 22.
Division of Biomedical Engineering for Health & Welfare, Tohoku University Graduate School of Biomedical Engineering, Sendai, Japan.



Oxysterol-binding protein (OSBP) is required for the perinuclear localization of intra-Golgi v-SNAREs.
Mol Biol Cell 2013 Nov 18;24(22):3534-44. Epub 2013 Sep 18.
Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo 113-0033, Japan Pathological Cell Biology Laboratory, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo 113-0033, Japan Department of Physiology and Biophysics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205.


Polyunsaturated fatty acid saturation by gut lactic acid bacteria affecting host lipid composition.
Proc Natl Acad Sci U S A 2013 Oct 14;110(44):17808-13. Epub 2013 Oct 14.
Division of Applied Life Sciences and Laboratory of Industrial Microbiology, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan.



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