Hiroyuki Aburatani

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Hiroyuki Aburatani

Publications by authors named "Hiroyuki Aburatani"

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100Publications

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DGC-specific mutations maintained cancer cell survival and promoted cell migration via ROCK inactivation.

Oncotarget 2018 May 1;9(33):23198-23207. Epub 2018 May 1.

Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.

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May 2018

JUNB governs a feed-forward network of TGFβ signaling that aggravates breast cancer invasion.

Nucleic Acids Res 2018 Feb;46(3):1180-1195

Ludwig Cancer Research, Science for Life Laboratory, Box 595, Biomedical Center, Uppsala University, SE-751 24 Uppsala, Sweden.

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February 2018

Genome-wide analysis revealed that DZNep reduces tubulointerstitial fibrosis via down-regulation of pro-fibrotic genes.

Sci Rep 2018 Feb 28;8(1):3779. Epub 2018 Feb 28.

Division of Nephrology and Endocrinology, The University of Tokyo Graduate School of Medicine, Bunkyō, Japan.

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February 2018

Overexpression of p54/NONO induces differential splicing and contributes to castration-resistant prostate cancer growth.

Oncotarget 2018 Feb 8;9(12):10510-10524. Epub 2018 Jan 8.

Laboratory for Systems Biology and Medicine (LSBM), Research Center for Advanced Science and Technology (RCAST), The University of Tokyo, Tokyo 153-8904, Japan.

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February 2018

Hypoxia-Inducible Factor-1α Activates the Transforming Growth Factor-β/SMAD3 Pathway in Kidney Tubular Epithelial Cells.

Am J Nephrol 2016 9;44(4):276-285. Epub 2016 Sep 9.

Division of Genome Science, Research Center for Advanced Science and Technology, University of Tokyo, Tokyo, Japan.

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January 2018

Identification of MYLK3 mutations in familial dilated cardiomyopathy.

Sci Rep 2017 Dec 13;7(1):17495. Epub 2017 Dec 13.

Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

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December 2017

Long Noncoding RNA JHDM1D-AS1 Promotes Tumor Growth by Regulating Angiogenesis in Response to Nutrient Starvation.

Mol Cell Biol 2017 Sep 28;37(18). Epub 2017 Aug 28.

Laboratory for Systems Biology and Medicine, RCAST, The University of Tokyo, Tokyo, Japan

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September 2017

Epstein-Barr virus infection induces genome-wide de novo DNA methylation in non-neoplastic gastric epithelial cells.

J Pathol 2017 Aug 25;242(4):391-399. Epub 2017 May 25.

Department of Molecular Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan.

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August 2017

Histone modification alteration coordinated with acquisition of promoter DNA methylation during Epstein-Barr virus infection.

Oncotarget 2017 Aug 21;8(33):55265-55279. Epub 2017 Jul 21.

Department of Molecular Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan.

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August 2017

Gastric Cancer With Primitive Enterocyte Phenotype: An Aggressive Subgroup of Intestinal-type Adenocarcinoma.

Am J Surg Pathol 2017 Jul;41(7):989-997

Departments of *Pathology ‡Gastrointestinal Surgery, Graduate School of Medicine †Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.

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July 2017

Echinomycin inhibits adipogenesis in 3T3-L1 cells in a HIF-independent manner.

Sci Rep 2017 Jul 26;7(1):6516. Epub 2017 Jul 26.

Division of Nephrology and Endocrinology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.

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July 2017

DNA-friendly Cu(ii)/TEMPO-catalyzed 5-hydroxymethylcytosine-specific oxidation.

Chem Commun (Camb) 2017 May;53(42):5756-5759

Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.

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May 2017

Dynamics of chromatin accessibility during TGF-β-induced EMT of Ras-transformed mammary gland epithelial cells.

Sci Rep 2017 04 26;7(1):1166. Epub 2017 Apr 26.

Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, 113-0033, Japan.

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April 2017

Extracellular Acidic pH Activates the Sterol Regulatory Element-Binding Protein 2 to Promote Tumor Progression.

Cell Rep 2017 02;18(9):2228-2242

The Translational Systems Biology and Medicine Initiative (TSBMI), Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, Tokyo 113-8655, Japan; Laboratory for Systems Biology and Medicine, RCAST, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo, 153-8904, Japan. Electronic address:

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February 2017

Base-Resolution Analysis of 5-Hydroxymethylcytosine by One-Pot Bisulfite-Free Chemical Conversion with Peroxotungstate.

J Am Chem Soc 2016 11 24;138(43):14178-14181. Epub 2016 Oct 24.

Department of Chemistry and Biotechnology, The University of Tokyo , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.

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November 2016

CASTIN: a system for comprehensive analysis of cancer-stromal interactome.

BMC Genomics 2016 11 9;17(1):899. Epub 2016 Nov 9.

Department of Genomic Pathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.

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November 2016

CellTree: an R/bioconductor package to infer the hierarchical structure of cell populations from single-cell RNA-seq data.

BMC Bioinformatics 2016 Sep 13;17(1):363. Epub 2016 Sep 13.

Graduate School of Frontier Sciences at the University of Tokyo, 5-1-5 Kashiwa-no-ha, Kashiwa, Japan.

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September 2016

Utility of ATRX immunohistochemistry in diagnosis of adult diffuse gliomas.

Histopathology 2016 Aug 23;69(2):260-7. Epub 2016 Feb 23.

Department of Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.

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August 2016

Network-based analysis for identification of candidate genes for colorectal cancer progression.

Biochem Biophys Res Commun 2016 08 30;476(4):534-540. Epub 2016 May 30.

Genome Science Division, Research Center for Advanced Science and Technologies, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, Japan.

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August 2016

Epigenomic Regulation of Smad1 Signaling During Cellular Senescence Induced by Ras Activation.

Methods Mol Biol 2016 ;1344:341-53

Genome Science Division, Research Center for Advanced Science and Technology (RCAST), The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo, 153-8904, Japan.

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May 2016

RHOA mutation in diffuse-type gastric cancer: a comparative clinicopathology analysis of 87 cases.

Gastric Cancer 2016 Apr 1;19(2):403-11. Epub 2015 Apr 1.

Department of Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

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April 2016

Age-Dependent Decrease of DNA Hydroxymethylation in Human T Cells.

J Clin Exp Hematop 2015 ;55(1):1-6

Department of Hematology, Graduate School of Comprehensive Human Science, University of Tsukuba.

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March 2016

Prognostic significance of CpG island methylator phenotype in surgically resected small cell lung carcinoma.

Cancer Sci 2016 Mar 19;107(3):320-5. Epub 2016 Feb 19.

Division of Pathology, The Cancer Institute, Department of Pathology, The Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.

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March 2016

SCF(Fbxo22)-KDM4A targets methylated p53 for degradation and regulates senescence.

Nat Commun 2016 Feb 12;7:10574. Epub 2016 Feb 12.

Department of Cell Biology, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho-cho, Mizuho-ku, 467-8601 Nagoya, Japan.

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February 2016

Epigenetic alteration to activate Bmp2-Smad signaling in Raf-induced senescence.

World J Biol Chem 2016 Feb;7(1):188-205

Mai Fujimoto, Shogo Yamamoto, Hiroyuki Aburatani, Atsushi Kaneda, Genome Science Division, Research Center for Advanced Science and Technology, the University of Tokyo, Tokyo 153-8904, Japan.

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February 2016

BMP Sustains Embryonic Stem Cell Self-Renewal through Distinct Functions of Different Krüppel-like Factors.

Stem Cell Reports 2016 Jan;6(1):64-73

Ludwig Institute for Cancer Research, Science for Life Laboratory, Uppsala University, 751 24 Uppsala, Sweden; Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan. Electronic address:

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January 2016

DNA methylation status as a biomarker of anti-epidermal growth factor receptor treatment for metastatic colorectal cancer.

Cancer Sci 2015 Dec 12;106(12):1722-9. Epub 2015 Nov 12.

Department of Clinical Oncology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.

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December 2015

Biological characterization of soft tissue sarcomas.

Ann Transl Med 2015 Dec;3(22):368

1 Department of Immunology and Infectious Disease, Shinshu University School of Medicine, Nagano, Japan ; 2 Promoting Business using Advanced Technology, Japan Science and Technology Agency (JST), Tokyo, Japan ; 3 Sigma-Aldrich Collaboration Laboratory, Rehovot 76100, Israel ; 4 Horiuchi Ladies Clinic, Nagano, Japan ; 5 Department of Laboratory Medicine, Shinshu University Hospital, Nagano, Japan ; 6 Department of Pathology, Keio University Graduate School of Medicine, Tokyo, Japan ; 7 The International Human Epigenome Consortium (IHEC) and CREST, Japan Science and Technology Agency (JST), Saitama, Japan ; 8 Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Miyagi, Japan ; 9 The Cancer System Laboratory, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan ; 10 Department of Obstetrics and Gynecology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

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December 2015

H3K4/H3K9me3 Bivalent Chromatin Domains Targeted by Lineage-Specific DNA Methylation Pauses Adipocyte Differentiation.

Mol Cell 2015 Nov;60(4):584-96

Division of Metabolic Medicine, The University of Tokyo, 4-6-1, Komaba, Meguro-ku, Tokyo 153-8904, Japan; The Translational Systems Biology and Medicine Initiative (TSBMI), Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, Tokyo 113-8655, Japan. Electronic address:

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November 2015

Distinct effects of Hoxa2 overexpression in cranial neural crest populations reveal that the mammalian hyomandibular-ceratohyal boundary maps within the styloid process.

Dev Biol 2015 Jun 16;402(2):162-74. Epub 2015 Apr 16.

Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), Chiyoda-ku, Tokyo 102-0076, Japan; Institute for Biology and Mathematics of Dynamical Cell Processes (iBMath), The University of Tokyo, 3-8-1 Komaba, Tokyo 153-8914, Japan. Electronic address:

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June 2015

JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis.

Nat Commun 2015 May 7;6:7052. Epub 2015 May 7.

1] Division of Metabolic Medicine, Research Center for Advanced Science and Technology (RCAST), The University of Tokyo, Tokyo 153-8904, Japan [2] The Translational Systems Biology and Medicine Initiative, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, University of Tokyo, Tokyo 113-8655, Japan.

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May 2015

A C-terminal mutant of CCAAT-enhancer-binding protein α (C/EBPα-Cm) downregulates Csf1r, a potent accelerator in the progression of acute myeloid leukemia with C/EBPα-Cm.

Exp Hematol 2015 Apr 20;43(4):300-8.e1. Epub 2014 Dec 20.

Division of Cellular Therapy, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Division of Stem Cell Signaling, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan. Electronic address:

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April 2015

A newly developed anti-Mucin 13 monoclonal antibody targets pancreatic ductal adenocarcinoma cells.

Int J Oncol 2015 Apr 5;46(4):1781-7. Epub 2015 Feb 5.

Department of Molecular Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.

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April 2015

The FBXL10/KDM2B scaffolding protein associates with novel polycomb repressive complex-1 to regulate adipogenesis.

J Biol Chem 2015 Feb 22;290(7):4163-77. Epub 2014 Dec 22.

From the Division of Metabolic Medicine, the Translational Systems Biology and Medicine Initiative Center for Disease Biology and Integrative Medicine, University of Tokyo, Tokyo 153-8904, Japan,

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February 2015

Integrative analysis of FOXP1 function reveals a tumor-suppressive effect in prostate cancer.

Mol Endocrinol 2014 Dec;28(12):2012-24

Departments of Anti-Aging Medicine (K.T., T.U., S.I.) and Geriatric Medicine (K.T., T.U., S.I.) and Department of Urology (T.F., Y.H.), Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan; Department of Pathology (T.S.), Tohoku University Graduate School of Medicine, Sendai, Miyagi, 980-8575, Japan; Genome Science Division (Sh.T., H.A.), Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo 153-8904, Japan; Department of Urology (Sa.T.), Nihon University School of Medicine, Itabashi-ku, Tokyo 173-0032, Japan; and Division of Gene Regulation and Signal Transduction (S.I.), Research Center for Genomic Medicine, Saitama Medical University, Hidaka, Saitama, 350-1241, Japan.

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December 2014

Global epigenomic analysis indicates protocadherin-7 activates osteoclastogenesis by promoting cell-cell fusion.

Biochem Biophys Res Commun 2014 Dec 13;455(3-4):305-11. Epub 2014 Nov 13.

Japan Science and Technology Agency, ERATO, Takayanagi Osteonetwork Project, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address:

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December 2014

Non-diethylstilbestrol exposed vaginal clear cell adenocarcinoma has a common molecular profile with ovarian clear cell adenocarcinoma: A case report.

Gynecol Oncol Rep 2014 Dec 5;10:49-52. Epub 2014 Jun 5.

Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.

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December 2014

Aberrant promoter methylation of PPP1R3C and EFHD1 in plasma of colorectal cancer patients.

Cancer Med 2014 Oct 24;3(5):1235-45. Epub 2014 May 24.

Department of Digestive Surgery and Pathology, Nihon University School of Medicine, Tokyo, Japan; Department of Molecular Oncology, Graduate school of Medicine, Chiba University, Chiba, Japan.

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October 2014

Potential biomarker for human uterine leiomyosarcoma.

J Clin Med Res 2014 Oct 28;6(5):392-4. Epub 2014 Jul 28.

Department of Obstetrics and Gynecology, Kyoto University Graduate School of Medicine, Kyoto, Kyoto 606-8507, Japan.

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October 2014

Transforming growth factor-β-induced lncRNA-Smad7 inhibits apoptosis of mouse breast cancer JygMC(A) cells.

Cancer Sci 2014 Aug 25;105(8):974-82. Epub 2014 Jul 25.

Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

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August 2014

A Smad3 and TTF-1/NKX2-1 complex regulates Smad4-independent gene expression.

Cell Res 2014 Aug 25;24(8):994-1008. Epub 2014 Jul 25.

Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan.

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August 2014

Hes1 promotes blast crisis in chronic myelogenous leukemia through MMP-9 upregulation in leukemic cells.

Blood 2014 Jun 13;123(25):3932-42. Epub 2014 May 13.

Division of Cellular Therapy, Advanced Clinical Research Center, Division of Stem Cell Signaling, Center for Stem Cell Therapy, Institute of Medical Science, The University of Tokyo, Tokyo, Japan;

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June 2014