Publications by authors named "Hiroyuki Aburatani"

100Publications

PPARα activation directly upregulates thrombomodulin in the diabetic retina.

Sci Rep 2020 07 2;10(1):10837. Epub 2020 Jul 2.

Department of Ophthalmology, St. Marianna University of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki, Kanagawa, Japan.

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http://dx.doi.org/10.1038/s41598-020-67579-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331602PMC
July 2020

Base editors for simultaneous introduction of C-to-T and A-to-G mutations.

Nat Biotechnol 2020 07 2;38(7):865-869. Epub 2020 Jun 2.

Synthetic Biology Division, Research Center for Advanced Science and Technology, University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1038/s41587-020-0509-0DOI Listing
July 2020

Pemafibrate, a selective PPARα modulator, prevents non-alcoholic steatohepatitis development without reducing the hepatic triglyceride content.

Sci Rep 2020 05 8;10(1):7818. Epub 2020 May 8.

Department of Nuclear Receptor Medicine, Laboratories for Systems Biology and Medicine (LSBM) at the Research Center for Advanced Science and Technology (RCAST), The University of Tokyo, Tokyo, 153-8904, Japan.

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http://dx.doi.org/10.1038/s41598-020-64902-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210999PMC
May 2020

Clinical diagnosis of a double primary sigmoid colon cancer and metastatic tumour using a gene-targeted panel test: a case report.

ANZ J Surg 2020 Nov 25;90(11):E139-E140. Epub 2020 Apr 25.

Department of Surgical Oncology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1111/ans.15921DOI Listing
November 2020

The first case of gastric carcinoma with NTRK rearrangement: identification of a novel ATP1B-NTRK1 fusion.

Gastric Cancer 2020 09 18;23(5):944-947. Epub 2020 Mar 18.

Department of Pathology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.

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http://dx.doi.org/10.1007/s10120-020-01061-9DOI Listing
September 2020

Initialization of epithelial cells by tumor cells in a metastatic microenvironment.

Oncogene 2020 03 3;39(12):2638-2640. Epub 2020 Feb 3.

National Hospital Organization Kyoto Medical Center, Kyoto, Kyoto, Japan.

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http://dx.doi.org/10.1038/s41388-020-1171-1DOI Listing
March 2020

Mesenchymal tumours with RREB1-MRTFB fusion involving the mediastinum: extra-glossal ectomesenchymal chondromyxoid tumours?

Histopathology 2020 Jun 22;76(7):1023-1031. Epub 2020 May 22.

Department of Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1111/his.14080DOI Listing
June 2020

Spinal solitary fibrous tumor of the neck: Next-generation sequencing-based analysis of genomic aberrations.

Auris Nasus Larynx 2019 Dec 23. Epub 2019 Dec 23.

Department of Otolaryngology-Head and Neck Surgery, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku , Tokyo 113-8655, Japan.

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http://dx.doi.org/10.1016/j.anl.2019.12.001DOI Listing
December 2019

A genome-scale CRISPR/Cas9 knockout screening reveals SH3D21 as a sensitizer for gemcitabine.

Sci Rep 2019 12 16;9(1):19188. Epub 2019 Dec 16.

Molecular Biology Department, Graduate School of Medicine, The University of Tokyo, Tokyo, 153-8904, Japan.

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http://dx.doi.org/10.1038/s41598-019-55893-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915784PMC
December 2019

Identification and characterization of the binding sequences and target genes of p53 lacking the 1st transactivation domain.

Cancer Sci 2020 Feb 13;111(2):451-466. Epub 2020 Jan 13.

Laboratory of Fundamental Oncology, National Cancer Center Research Institute, Tokyo, Japan.

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http://dx.doi.org/10.1111/cas.14279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004532PMC
February 2020

In vivo effects of mutant RHOA on tumor formation in an orthotopic inoculation model.

Oncol Rep 2019 Nov 3;42(5):1745-1754. Epub 2019 Sep 3.

Department of Research, Forerunner Pharma Research Co., Ltd., Komaba Open Laboratory, The University of Tokyo, Tokyo 153‑8904, Japan.

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http://dx.doi.org/10.3892/or.2019.7300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775816PMC
November 2019

Profiling of Target Molecules for Immunotherapy in Mesenchymal Tumors.

J Clin Med Res 2019 Aug 27;11(8):609-613. Epub 2019 Jul 27.

National Hospital Organization Kyoto Medical Center, Kyoto, Japan.

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http://dx.doi.org/10.14740/jocmr3886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681852PMC
August 2019

[Machine Learning Applications in Cancer Genome Medicine].

Gan To Kagaku Ryoho 2019 Mar;46(3):423-426

Division of Genome Science, Research Center for Advanced Science and Technologies, The University of Tokyo.

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March 2019

Downregulation of ERG and FLI1 expression in endothelial cells triggers endothelial-to-mesenchymal transition.

PLoS Genet 2018 11 30;14(11):e1007826. Epub 2018 Nov 30.

Division of Molecular and Vascular Biology, IRDA, Kumamoto University, Kumamoto, Japan.

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http://dx.doi.org/10.1371/journal.pgen.1007826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291168PMC
November 2018

EWS-FLI1 regulates a transcriptional program in cooperation with Foxq1 in mouse Ewing sarcoma.

Cancer Sci 2018 Sep 18;109(9):2907-2918. Epub 2018 Jul 18.

Division of Carcinogenesis, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan.

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http://dx.doi.org/10.1111/cas.13710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125457PMC
September 2018

DGC-specific mutations maintained cancer cell survival and promoted cell migration via ROCK inactivation.

Oncotarget 2018 May 1;9(33):23198-23207. Epub 2018 May 1.

Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.18632/oncotarget.25269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955407PMC
May 2018

Overexpression of p54/NONO induces differential splicing and contributes to castration-resistant prostate cancer growth.

Oncotarget 2018 Feb 8;9(12):10510-10524. Epub 2018 Jan 8.

Laboratory for Systems Biology and Medicine (LSBM), Research Center for Advanced Science and Technology (RCAST), The University of Tokyo, Tokyo 153-8904, Japan.

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http://dx.doi.org/10.18632/oncotarget.24063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828187PMC
February 2018

Genome-wide analysis revealed that DZNep reduces tubulointerstitial fibrosis via down-regulation of pro-fibrotic genes.

Sci Rep 2018 02 28;8(1):3779. Epub 2018 Feb 28.

Division of Nephrology and Endocrinology, The University of Tokyo Graduate School of Medicine, Bunkyō, Japan.

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http://dx.doi.org/10.1038/s41598-018-22180-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830881PMC
February 2018

Identification of MYLK3 mutations in familial dilated cardiomyopathy.

Sci Rep 2017 12 13;7(1):17495. Epub 2017 Dec 13.

Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1038/s41598-017-17769-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727479PMC
December 2017

Identification of a novel fusion gene HMGA2-EGFR in glioblastoma.

Int J Cancer 2018 04 11;142(8):1627-1639. Epub 2017 Dec 11.

Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1002/ijc.31179DOI Listing
April 2018

JUNB governs a feed-forward network of TGFβ signaling that aggravates breast cancer invasion.

Nucleic Acids Res 2018 02;46(3):1180-1195

Ludwig Cancer Research, Science for Life Laboratory, Box 595, Biomedical Center, Uppsala University, SE-751 24 Uppsala, Sweden.

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http://dx.doi.org/10.1093/nar/gkx1190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814809PMC
February 2018

Echinomycin inhibits adipogenesis in 3T3-L1 cells in a HIF-independent manner.

Sci Rep 2017 07 26;7(1):6516. Epub 2017 Jul 26.

Division of Nephrology and Endocrinology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1038/s41598-017-06761-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529514PMC
July 2017

Long Noncoding RNA JHDM1D-AS1 Promotes Tumor Growth by Regulating Angiogenesis in Response to Nutrient Starvation.

Mol Cell Biol 2017 Sep 28;37(18). Epub 2017 Aug 28.

Laboratory for Systems Biology and Medicine, RCAST, The University of Tokyo, Tokyo, Japan

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http://dx.doi.org/10.1128/MCB.00125-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574049PMC
September 2017

Gastric Cancer With Primitive Enterocyte Phenotype: An Aggressive Subgroup of Intestinal-type Adenocarcinoma.

Am J Surg Pathol 2017 Jul;41(7):989-997

Departments of *Pathology ‡Gastrointestinal Surgery, Graduate School of Medicine †Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1097/PAS.0000000000000869DOI Listing
July 2017

DNA-friendly Cu(ii)/TEMPO-catalyzed 5-hydroxymethylcytosine-specific oxidation.

Chem Commun (Camb) 2017 May;53(42):5756-5759

Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.

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http://dx.doi.org/10.1039/c7cc02814hDOI Listing
May 2017

Dynamics of chromatin accessibility during TGF-β-induced EMT of Ras-transformed mammary gland epithelial cells.

Sci Rep 2017 04 26;7(1):1166. Epub 2017 Apr 26.

Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, 113-0033, Japan.

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http://dx.doi.org/10.1038/s41598-017-00973-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430828PMC
April 2017

Epstein-Barr virus infection induces genome-wide de novo DNA methylation in non-neoplastic gastric epithelial cells.

J Pathol 2017 08 25;242(4):391-399. Epub 2017 May 25.

Department of Molecular Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan.

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http://dx.doi.org/10.1002/path.4909DOI Listing
August 2017

Extracellular Acidic pH Activates the Sterol Regulatory Element-Binding Protein 2 to Promote Tumor Progression.

Cell Rep 2017 02;18(9):2228-2242

The Translational Systems Biology and Medicine Initiative (TSBMI), Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, Tokyo 113-8655, Japan; Laboratory for Systems Biology and Medicine, RCAST, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo, 153-8904, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.02.006DOI Listing
February 2017

CASTIN: a system for comprehensive analysis of cancer-stromal interactome.

BMC Genomics 2016 11 9;17(1):899. Epub 2016 Nov 9.

Department of Genomic Pathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.

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http://dx.doi.org/10.1186/s12864-016-3207-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5103609PMC
November 2016

Base-Resolution Analysis of 5-Hydroxymethylcytosine by One-Pot Bisulfite-Free Chemical Conversion with Peroxotungstate.

J Am Chem Soc 2016 11 24;138(43):14178-14181. Epub 2016 Oct 24.

Department of Chemistry and Biotechnology, The University of Tokyo , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.

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http://dx.doi.org/10.1021/jacs.6b06428DOI Listing
November 2016

Hypoxia-Inducible Factor-1α Activates the Transforming Growth Factor-β/SMAD3 Pathway in Kidney Tubular Epithelial Cells.

Am J Nephrol 2016 9;44(4):276-285. Epub 2016 Sep 9.

Division of Genome Science, Research Center for Advanced Science and Technology, University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1159/000449323DOI Listing
January 2018