Hiroyuki Aburatani

Hiroyuki Aburatani

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Hiroyuki Aburatani

Hiroyuki Aburatani

Publications by authors named "Hiroyuki Aburatani"

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In vivo effects of mutant RHOA on tumor formation in an orthotopic inoculation model.

Oncol Rep 2019 Nov 3;42(5):1745-1754. Epub 2019 Sep 3.

Department of Research, Forerunner Pharma Research Co., Ltd., Komaba Open Laboratory, The University of Tokyo, Tokyo 153‑8904, Japan.

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http://dx.doi.org/10.3892/or.2019.7300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775816PMC
November 2019

Profiling of Target Molecules for Immunotherapy in Mesenchymal Tumors.

J Clin Med Res 2019 Aug 27;11(8):609-613. Epub 2019 Jul 27.

National Hospital Organization Kyoto Medical Center, Kyoto, Japan.

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http://dx.doi.org/10.14740/jocmr3886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681852PMC
August 2019

[Machine Learning Applications in Cancer Genome Medicine].

Gan To Kagaku Ryoho 2019 Mar;46(3):423-426

Division of Genome Science, Research Center for Advanced Science and Technologies, The University of Tokyo.

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March 2019

Downregulation of ERG and FLI1 expression in endothelial cells triggers endothelial-to-mesenchymal transition.

PLoS Genet 2018 11 30;14(11):e1007826. Epub 2018 Nov 30.

Division of Molecular and Vascular Biology, IRDA, Kumamoto University, Kumamoto, Japan.

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http://dx.doi.org/10.1371/journal.pgen.1007826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291168PMC
November 2018

EWS-FLI1 regulates a transcriptional program in cooperation with Foxq1 in mouse Ewing sarcoma.

Cancer Sci 2018 Sep 18;109(9):2907-2918. Epub 2018 Jul 18.

Division of Carcinogenesis, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan.

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http://dx.doi.org/10.1111/cas.13710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125457PMC
September 2018

DGC-specific mutations maintained cancer cell survival and promoted cell migration via ROCK inactivation.

Oncotarget 2018 May 1;9(33):23198-23207. Epub 2018 May 1.

Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.18632/oncotarget.25269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955407PMC
May 2018

Identification of a novel fusion gene HMGA2-EGFR in glioblastoma.

Int J Cancer 2018 04 11;142(8):1627-1639. Epub 2017 Dec 11.

Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1002/ijc.31179DOI Listing
April 2018

JUNB governs a feed-forward network of TGFβ signaling that aggravates breast cancer invasion.

Nucleic Acids Res 2018 02;46(3):1180-1195

Ludwig Cancer Research, Science for Life Laboratory, Box 595, Biomedical Center, Uppsala University, SE-751 24 Uppsala, Sweden.

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http://dx.doi.org/10.1093/nar/gkx1190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814809PMC
February 2018

Genome-wide analysis revealed that DZNep reduces tubulointerstitial fibrosis via down-regulation of pro-fibrotic genes.

Sci Rep 2018 02 28;8(1):3779. Epub 2018 Feb 28.

Division of Nephrology and Endocrinology, The University of Tokyo Graduate School of Medicine, Bunkyō, Japan.

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http://dx.doi.org/10.1038/s41598-018-22180-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830881PMC
February 2018

Overexpression of p54/NONO induces differential splicing and contributes to castration-resistant prostate cancer growth.

Oncotarget 2018 Feb 8;9(12):10510-10524. Epub 2018 Jan 8.

Laboratory for Systems Biology and Medicine (LSBM), Research Center for Advanced Science and Technology (RCAST), The University of Tokyo, Tokyo 153-8904, Japan.

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http://dx.doi.org/10.18632/oncotarget.24063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828187PMC
February 2018

Hypoxia-Inducible Factor-1α Activates the Transforming Growth Factor-β/SMAD3 Pathway in Kidney Tubular Epithelial Cells.

Am J Nephrol 2016 9;44(4):276-285. Epub 2016 Sep 9.

Division of Genome Science, Research Center for Advanced Science and Technology, University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1159/000449323DOI Listing
January 2018

Identification of MYLK3 mutations in familial dilated cardiomyopathy.

Sci Rep 2017 12 13;7(1):17495. Epub 2017 Dec 13.

Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1038/s41598-017-17769-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727479PMC
December 2017

Long Noncoding RNA JHDM1D-AS1 Promotes Tumor Growth by Regulating Angiogenesis in Response to Nutrient Starvation.

Mol Cell Biol 2017 Sep 28;37(18). Epub 2017 Aug 28.

Laboratory for Systems Biology and Medicine, RCAST, The University of Tokyo, Tokyo, Japan

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http://dx.doi.org/10.1128/MCB.00125-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574049PMC
September 2017

Epstein-Barr virus infection induces genome-wide de novo DNA methylation in non-neoplastic gastric epithelial cells.

J Pathol 2017 08 25;242(4):391-399. Epub 2017 May 25.

Department of Molecular Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan.

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http://dx.doi.org/10.1002/path.4909DOI Listing
August 2017

Gastric Cancer With Primitive Enterocyte Phenotype: An Aggressive Subgroup of Intestinal-type Adenocarcinoma.

Am J Surg Pathol 2017 Jul;41(7):989-997

Departments of *Pathology ‡Gastrointestinal Surgery, Graduate School of Medicine †Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1097/PAS.0000000000000869DOI Listing
July 2017

Echinomycin inhibits adipogenesis in 3T3-L1 cells in a HIF-independent manner.

Sci Rep 2017 07 26;7(1):6516. Epub 2017 Jul 26.

Division of Nephrology and Endocrinology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1038/s41598-017-06761-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529514PMC
July 2017

DNA-friendly Cu(ii)/TEMPO-catalyzed 5-hydroxymethylcytosine-specific oxidation.

Chem Commun (Camb) 2017 May;53(42):5756-5759

Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.

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http://dx.doi.org/10.1039/c7cc02814hDOI Listing
May 2017

Dynamics of chromatin accessibility during TGF-β-induced EMT of Ras-transformed mammary gland epithelial cells.

Sci Rep 2017 04 26;7(1):1166. Epub 2017 Apr 26.

Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, 113-0033, Japan.

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http://dx.doi.org/10.1038/s41598-017-00973-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430828PMC
April 2017

Extracellular Acidic pH Activates the Sterol Regulatory Element-Binding Protein 2 to Promote Tumor Progression.

Cell Rep 2017 02;18(9):2228-2242

The Translational Systems Biology and Medicine Initiative (TSBMI), Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, Tokyo 113-8655, Japan; Laboratory for Systems Biology and Medicine, RCAST, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo, 153-8904, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.02.006DOI Listing
February 2017

Base-Resolution Analysis of 5-Hydroxymethylcytosine by One-Pot Bisulfite-Free Chemical Conversion with Peroxotungstate.

J Am Chem Soc 2016 11 24;138(43):14178-14181. Epub 2016 Oct 24.

Department of Chemistry and Biotechnology, The University of Tokyo , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.

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http://dx.doi.org/10.1021/jacs.6b06428DOI Listing
November 2016

CASTIN: a system for comprehensive analysis of cancer-stromal interactome.

BMC Genomics 2016 11 9;17(1):899. Epub 2016 Nov 9.

Department of Genomic Pathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.

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http://dx.doi.org/10.1186/s12864-016-3207-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5103609PMC
November 2016

CellTree: an R/bioconductor package to infer the hierarchical structure of cell populations from single-cell RNA-seq data.

BMC Bioinformatics 2016 Sep 13;17(1):363. Epub 2016 Sep 13.

Graduate School of Frontier Sciences at the University of Tokyo, 5-1-5 Kashiwa-no-ha, Kashiwa, Japan.

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http://dx.doi.org/10.1186/s12859-016-1175-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020541PMC
September 2016

Utility of ATRX immunohistochemistry in diagnosis of adult diffuse gliomas.

Histopathology 2016 Aug 23;69(2):260-7. Epub 2016 Feb 23.

Department of Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1111/his.12927DOI Listing
August 2016

Network-based analysis for identification of candidate genes for colorectal cancer progression.

Biochem Biophys Res Commun 2016 08 30;476(4):534-540. Epub 2016 May 30.

Genome Science Division, Research Center for Advanced Science and Technologies, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2016.05.158DOI Listing
August 2016

Ras and TGF-β signaling enhance cancer progression by promoting the ΔNp63 transcriptional program.

Sci Signal 2016 08 23;9(442):ra84. Epub 2016 Aug 23.

Ludwig Cancer Research, Science for Life Laboratory, Uppsala University, Box 595, Biomedical Center, SE-751 24 Uppsala, Sweden.

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http://dx.doi.org/10.1126/scisignal.aag3232DOI Listing
August 2016

Epigenomic Regulation of Smad1 Signaling During Cellular Senescence Induced by Ras Activation.

Methods Mol Biol 2016 ;1344:341-53

Genome Science Division, Research Center for Advanced Science and Technology (RCAST), The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo, 153-8904, Japan.

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http://dx.doi.org/10.1007/978-1-4939-2966-5_22DOI Listing
May 2016

Prognostic significance of CpG island methylator phenotype in surgically resected small cell lung carcinoma.

Cancer Sci 2016 Mar 19;107(3):320-5. Epub 2016 Feb 19.

Division of Pathology, The Cancer Institute, Department of Pathology, The Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.

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http://dx.doi.org/10.1111/cas.12876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814245PMC
March 2016

SCF(Fbxo22)-KDM4A targets methylated p53 for degradation and regulates senescence.

Nat Commun 2016 Feb 12;7:10574. Epub 2016 Feb 12.

Department of Cell Biology, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho-cho, Mizuho-ku, 467-8601 Nagoya, Japan.

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http://dx.doi.org/10.1038/ncomms10574DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754341PMC
February 2016

Epigenetic alteration to activate Bmp2-Smad signaling in Raf-induced senescence.

World J Biol Chem 2016 Feb;7(1):188-205

Mai Fujimoto, Shogo Yamamoto, Hiroyuki Aburatani, Atsushi Kaneda, Genome Science Division, Research Center for Advanced Science and Technology, the University of Tokyo, Tokyo 153-8904, Japan.

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http://dx.doi.org/10.4331/wjbc.v7.i1.188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768123PMC
February 2016

BMP Sustains Embryonic Stem Cell Self-Renewal through Distinct Functions of Different Krüppel-like Factors.

Stem Cell Reports 2016 Jan;6(1):64-73

Ludwig Institute for Cancer Research, Science for Life Laboratory, Uppsala University, 751 24 Uppsala, Sweden; Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22136711150036
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http://dx.doi.org/10.1016/j.stemcr.2015.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719190PMC
January 2016

Biological characterization of soft tissue sarcomas.

Ann Transl Med 2015 Dec;3(22):368

1 Department of Immunology and Infectious Disease, Shinshu University School of Medicine, Nagano, Japan ; 2 Promoting Business using Advanced Technology, Japan Science and Technology Agency (JST), Tokyo, Japan ; 3 Sigma-Aldrich Collaboration Laboratory, Rehovot 76100, Israel ; 4 Horiuchi Ladies Clinic, Nagano, Japan ; 5 Department of Laboratory Medicine, Shinshu University Hospital, Nagano, Japan ; 6 Department of Pathology, Keio University Graduate School of Medicine, Tokyo, Japan ; 7 The International Human Epigenome Consortium (IHEC) and CREST, Japan Science and Technology Agency (JST), Saitama, Japan ; 8 Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Miyagi, Japan ; 9 The Cancer System Laboratory, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan ; 10 Department of Obstetrics and Gynecology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

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http://dx.doi.org/10.3978/j.issn.2305-5839.2015.12.33DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4701514PMC
December 2015

H3K4/H3K9me3 Bivalent Chromatin Domains Targeted by Lineage-Specific DNA Methylation Pauses Adipocyte Differentiation.

Mol Cell 2015 Nov;60(4):584-96

Division of Metabolic Medicine, The University of Tokyo, 4-6-1, Komaba, Meguro-ku, Tokyo 153-8904, Japan; The Translational Systems Biology and Medicine Initiative (TSBMI), Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, Tokyo 113-8655, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.10.025DOI Listing
November 2015