Hiroyasu Esumi

Hiroyasu Esumi

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Hiroyasu Esumi

Publications by authors named "Hiroyasu Esumi"

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100Publications

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Characterization of cancer omics and drug perturbations in panels of lung cancer cells.

Sci Rep 2019 12 20;9(1):19529. Epub 2019 Dec 20.

Division of Translational Informatics, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Chiba, Japan.

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http://dx.doi.org/10.1038/s41598-019-55692-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925249PMC
December 2019

Sucrose nonfermenting AMPK-related kinase (SNARK) regulates exercise-stimulated and ischemia-stimulated glucose transport in the heart.

J Cell Biochem 2019 01 7;120(1):685-696. Epub 2018 Sep 7.

Integrative Physiology and Metabolism Section, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1002/jcb.27425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347018PMC
January 2019

Metabolic Determinants of Sensitivity to Phosphatidylinositol 3-Kinase Pathway Inhibitor in Small-Cell Lung Carcinoma.

Cancer Res 2018 05 28;78(9):2179-2190. Epub 2018 Feb 28.

Division of Translational Genomics, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Chiba, Japan.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-2109DOI Listing
May 2018

Oncogenic Kit signalling on the Golgi is suppressed by blocking secretory trafficking with M-COPA in gastrointestinal stromal tumours.

Cancer Lett 2018 02 28;415:1-10. Epub 2017 Nov 28.

Division of Immunobiology, Research Institute for Biomedical Sciences, Tokyo University of Science, Noda 278-0022, Chiba, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2017.11.032DOI Listing
February 2018

Highly oxygenated antiausterity agents from the leaves of Uvaria dac.

Bioorg Med Chem Lett 2017 05 11;27(9):1967-1971. Epub 2017 Mar 11.

Research Institute for Biomedical Sciences, Tokyo University of Science, 2669 Yamazaki, Noda, Chiba 278-8510, Japan.

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http://dx.doi.org/10.1016/j.bmcl.2017.03.021DOI Listing
May 2017

Development of Highly Selective Fluorescent Probe Enabling Flow-Cytometric Isolation of ALDH3A1-Positive Viable Cells.

Bioconjug Chem 2017 02 15;28(2):302-306. Epub 2016 Dec 15.

CREST, Japan Science and Technology Agency , 7 Gobancho, Chiyoda-ku, Tokyo 102-0076, Japan.

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http://dx.doi.org/10.1021/acs.bioconjchem.6b00618DOI Listing
February 2017

Constituents of the Rhizomes of Boesenbergia pandurata and Their Antiausterity Activities against the PANC-1 Human Pancreatic Cancer Line.

J Nat Prod 2017 01 18;80(1):141-148. Epub 2017 Jan 18.

Division of Natural Drug Discovery, Institute of Natural Medicine, University of Toyama , 2630 Sugitani, Toyama 930-0194, Japan.

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http://pubs.acs.org/doi/10.1021/acs.jnatprod.6b00784
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http://dx.doi.org/10.1021/acs.jnatprod.6b00784DOI Listing
January 2017

Chemical Constituents of Mangifera indica and Their Antiausterity Activity against the PANC-1 Human Pancreatic Cancer Cell Line.

J Nat Prod 2016 08 28;79(8):2053-9. Epub 2016 Jul 28.

Division of Natural Drug Discovery, Department of Translational Research, Institute of Natural Medicine, University of Toyama , 2630 Sugitani, Toyama 930-0194, Japan.

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http://pubs.acs.org/doi/10.1021/acs.jnatprod.6b00381
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http://dx.doi.org/10.1021/acs.jnatprod.6b00381DOI Listing
August 2016

Synthesis of new tricyclic thiolactams as potent antitumor agent for pancreatic cancer.

Bioorg Med Chem Lett 2016 06 16;26(11):2577-9. Epub 2016 Apr 16.

Graduate School of Science and Technology, University of Toyama, Toyama 930-8555, Japan; Graduate School of Innovative Life Science, University of Toyama, 930-8555, Japan.

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http://dx.doi.org/10.1016/j.bmcl.2016.04.035DOI Listing
June 2016

[Therapeutic strategies targeting cancer--specific metabolism].

Nihon Rinsho 2015 Aug;73(8):1296-301

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August 2015

Signaling through the Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Axis Is Responsible for Aerobic Glycolysis mediated by Glucose Transporter in Epidermal Growth Factor Receptor (EGFR)-mutated Lung Adenocarcinoma.

J Biol Chem 2015 Jul 28;290(28):17495-504. Epub 2015 May 28.

From the Division of Translational Research, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Chiba 277-8577, Japan, the Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba 277-8561.

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http://dx.doi.org/10.1074/jbc.M115.660498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498084PMC
July 2015

Aberrant transcriptional regulations in cancers: genome, transcriptome and epigenome analysis of lung adenocarcinoma cell lines.

Nucleic Acids Res 2014 Dec 6;42(22):13557-72. Epub 2014 Nov 6.

Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan Department of Computational Biology, Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan

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http://academic.oup.com/nar/article/42/22/13557/2411848/Aber
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http://dx.doi.org/10.1093/nar/gku885DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267666PMC
December 2014

Oncogenic Kit signals on endolysosomes and endoplasmic reticulum are essential for neoplastic mast cell proliferation.

Nat Commun 2014 Dec 10;5:5715. Epub 2014 Dec 10.

Division of Immunobiology, Research Institute for Biomedical Sciences, Tokyo University of Science, Noda, Chiba 278-0022, Japan.

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http://dx.doi.org/10.1038/ncomms6715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284665PMC
December 2014

(+)-Grandifloracin, an antiausterity agent, induces autophagic PANC-1 pancreatic cancer cell death.

Drug Des Devel Ther 2014 18;8:39-47. Epub 2013 Dec 18.

Frontier Research Core for Life Sciences, Toyama, Japan ; Institute of Natural Medicine, University of Toyama, Toyama, Japan.

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http://dx.doi.org/10.2147/DDDT.S52168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3872082PMC
November 2014

Mechanisms of regulation of PFKFB expression in pancreatic and gastric cancer cells.

World J Gastroenterol 2014 Oct;20(38):13705-17

Oleksandr H Minchenko, Dmytro O Minchenko, Department of Molecular Biology, Palladin Institute of Biochemistry, Kiev 01601, Ukraine.

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http://dx.doi.org/10.3748/wjg.v20.i38.13705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4194554PMC
October 2014

Therapeutic priority of the PI3K/AKT/mTOR pathway in small cell lung cancers as revealed by a comprehensive genomic analysis.

J Thorac Oncol 2014 Sep;9(9):1324-31

*Division of Thoracic Oncology, National Cancer Center Hospital East; †Exploratory Oncology Research and Clinical Trial Center, National Cancer Center; ‡Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East; §Division of Thoracic Surgery, National Cancer Center Hospital East, Kashiwa, Japan; and ‖Division of Genome Biology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.

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http://dx.doi.org/10.1097/JTO.0000000000000250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154841PMC
September 2014

Effect of a poly(ADP-ribose) polymerase-1 inhibitor against esophageal squamous cell carcinoma cell lines.

Cancer Sci 2014 Feb 5;105(2):202-10. Epub 2013 Dec 5.

Division of Translational Research, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Chiba, Japan; Department of Otorhinolaryngology, University of Kitasato Hospital, Minami-ku, Sagamihara, Kanagawa, Japan.

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http://dx.doi.org/10.1111/cas.12322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317825PMC
February 2014

"S'ils n'ont pas de pain, qu'ils mangent de la brioche." Focus on "anaerobic respiration sustains mitochondrial membrane potential in a prolyl hydroxylase pathway-activated cancer cell line in a hypoxic microenvironment".

Authors:
Hiroyasu Esumi

Am J Physiol Cell Physiol 2014 Feb 11;306(4):C320-1. Epub 2013 Dec 11.

Research Institute for Biomedical Sciences, Tokyo University of Science, Yamazaki, Noda, Chiba, Japan.

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http://dx.doi.org/10.1152/ajpcell.00362.2013DOI Listing
February 2014

Critical role of H2O2 generated by NOX4 during cellular response under glucose deprivation.

PLoS One 2013 21;8(3):e56628. Epub 2013 Mar 21.

Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0056628PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605446PMC
September 2013

Identification of a lung adenocarcinoma cell line with CCDC6-RET fusion gene and the effect of RET inhibitors in vitro and in vivo.

Cancer Sci 2013 Jul 12;104(7):896-903. Epub 2013 May 12.

Division of Translational Research, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.

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http://dx.doi.org/10.1111/cas.12175DOI Listing
July 2013

Metabolomic profiling of lung and prostate tumor tissues by capillary electrophoresis time-of-flight mass spectrometry.

Metabolomics 2013 Apr 2;9(2):444-453. Epub 2012 Nov 2.

Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata Japan ; Systems Biology Program, Graduate School of Media and Governance, Keio University, Fujisawa, Kanagawa Japan.

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http://link.springer.com/10.1007/s11306-012-0452-2
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http://dx.doi.org/10.1007/s11306-012-0452-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608864PMC
April 2013

Synthesis and antitumor evaluation of arctigenin derivatives based on antiausterity strategy.

Eur J Med Chem 2013 Feb 28;60:76-88. Epub 2012 Nov 28.

Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.

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http://dx.doi.org/10.1016/j.ejmech.2012.11.031DOI Listing
February 2013

Loss of HGF activator inhibits foveolar hyperplasia induced by oxyntic atrophy without altering gastrin levels.

Am J Physiol Gastrointest Liver Physiol 2012 Dec 11;303(11):G1254-61. Epub 2012 Oct 11.

Department of Gastrointestinal Surgery, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.

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http://dx.doi.org/10.1152/ajpgi.00107.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888532PMC
December 2012

An anticancer agent, pyrvinium pamoate inhibits the NADH-fumarate reductase system--a unique mitochondrial energy metabolism in tumour microenvironments.

J Biochem 2012 Aug 23;152(2):171-83. Epub 2012 Apr 23.

Cancer Physiology Project, Research Center for Innovative Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba 277-8577, Japan.

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http://dx.doi.org/10.1093/jb/mvs041DOI Listing
August 2012

Mitochondrial fumarate reductase as a target of chemotherapy: from parasites to cancer cells.

Biochim Biophys Acta 2012 May 29;1820(5):643-51. Epub 2011 Dec 29.

Department of Biomedical Chemistry, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.bbagen.2011.12.013DOI Listing
May 2012

Muscle-specific knock-out of NUAK family SNF1-like kinase 1 (NUAK1) prevents high fat diet-induced glucose intolerance.

J Biol Chem 2012 May 14;287(20):16379-89. Epub 2012 Mar 14.

Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa 277-8561, Japan.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M111.302687
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http://dx.doi.org/10.1074/jbc.M111.302687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351321PMC
May 2012

Synthesis and evaluation of anticancer natural product analogues based on angelmarin: targeting the tolerance towards nutrient deprivation.

ChemMedChem 2012 May 16;7(5):766-70. Epub 2012 Mar 16.

Eskitis Institute for Cell and Molecular Therapies (N75), Griffith University, Nathan, QLD, Australia.

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http://doi.wiley.com/10.1002/cmdc.201100564
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http://dx.doi.org/10.1002/cmdc.201100564DOI Listing
May 2012

Identification of chrysoplenetin from Vitex negundo as a potential cytotoxic agent against PANC-1 and a panel of 39 human cancer cell lines (JFCR-39).

Phytother Res 2011 Dec 6;25(12):1770-5. Epub 2011 Apr 6.

Institute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama, 930-0194, Japan.

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http://dx.doi.org/10.1002/ptr.3441DOI Listing
December 2011

Hypoglycemic/hypoxic condition in vitro mimicking the tumor microenvironment markedly reduced the efficacy of anticancer drugs.

Cancer Sci 2011 May 7;102(5):975-82. Epub 2011 Mar 7.

Cancer Physiology Project, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.

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http://dx.doi.org/10.1111/j.1349-7006.2011.01880.xDOI Listing
May 2011

Biased discordance of KRAS mutation detection in archived colorectal cancer specimens between the ARMS-Scorpion method and direct sequencing.

Jpn J Clin Oncol 2011 Feb 26;41(2):239-44. Epub 2010 Nov 26.

Cancer Physiology Project, National Cancer Center Hospital East, Kashiwa, Chiba 277-8577, Japan.

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http://dx.doi.org/10.1093/jjco/hyq216DOI Listing
February 2011

Feasibility and robustness of amplification refractory mutation system (ARMS)-based KRAS testing using clinically available formalin-fixed, paraffin-embedded samples of colorectal cancers.

Jpn J Clin Oncol 2011 Jan 9;41(1):52-6. Epub 2010 Aug 9.

Cancer Physiology Project, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Japan.

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http://dx.doi.org/10.1093/jjco/hyq151DOI Listing
January 2011

Measurement and verification of positron emitter nuclei generated at each treatment site by target nuclear fragment reactions in proton therapy.

Med Phys 2010 Aug;37(8):4445-55

Department of Nuclear Engineering and Management, Graduate School of Engineering, University of Tokyo, Japan.

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http://doi.wiley.com/10.1118/1.3462559
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http://dx.doi.org/10.1118/1.3462559DOI Listing
August 2010

The NADH-fumarate reductase system, a novel mitochondrial energy metabolism, is a new target for anticancer therapy in tumor microenvironments.

Ann N Y Acad Sci 2010 Jul;1201:44-9

Investigative Treatment Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Chiba, Japan.

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http://doi.wiley.com/10.1111/j.1749-6632.2010.05620.x
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http://dx.doi.org/10.1111/j.1749-6632.2010.05620.xDOI Listing
July 2010

Study on the constituents of Mexican propolis and their cytotoxic activity against PANC-1 human pancreatic cancer cells.

J Nat Prod 2010 Apr;73(4):623-7

Institute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama 930-0194, Japan.

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http://dx.doi.org/10.1021/np900772mDOI Listing
April 2010

Mitochondrial inhibitors show preferential cytotoxicity to human pancreatic cancer PANC-1 cells under glucose-deprived conditions.

Biochem Biophys Res Commun 2010 Feb 18;392(3):460-6. Epub 2010 Jan 18.

Numazu Bio-Medical Research Institute, Microbial Chemistry Research Center, Shizuoka, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2010.01.050DOI Listing
February 2010

The development and clinical use of a beam ON-LINE PET system mounted on a rotating gantry port in proton therapy.

Int J Radiat Oncol Biol Phys 2010 Jan;76(1):277-86

Particle Therapy Division, Research Center for Innovative Oncology, National Cancer Center, Kashiwa.

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https://linkinghub.elsevier.com/retrieve/pii/S03603016090092
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http://dx.doi.org/10.1016/j.ijrobp.2009.05.065DOI Listing
January 2010

Regulation of succinate-ubiquinone reductase and fumarate reductase activities in human complex II by phosphorylation of its flavoprotein subunit.

Proc Jpn Acad Ser B Phys Biol Sci 2009 ;85(7):258-65

Cancer Physiology Project, Investigative Treatment Division, National Cancer Center Research Institute East, Chiba, Japan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561849PMC
http://dx.doi.org/10.2183/pjab.85.258DOI Listing
October 2009

Cytotoxic constituents of Soymida febrifuga from Myanmar.

J Nat Prod 2009 Sep;72(9):1631-6

Institute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama, Japan.

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http://pubs.acs.org/doi/abs/10.1021/np9003323
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http://dx.doi.org/10.1021/np9003323DOI Listing
September 2009

Improvement of radiation-induced healing delay by etanercept treatment in rat arteries.

Cancer Sci 2009 Aug 4;100(8):1550-5. Epub 2009 May 4.

Experimental Animal Laboratory, Kashiwa, Chiba 277-8577, Japan.

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http://dx.doi.org/10.1111/j.1349-7006.2009.01205.xDOI Listing
August 2009

Chemical constituents of propolis from Myanmar and their preferential cytotoxicity against a human pancreatic cancer cell line.

J Nat Prod 2009 Jul;72(7):1283-7

Institute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama 930-0194, Japan.

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http://pubs.acs.org/doi/abs/10.1021/np9002433
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http://dx.doi.org/10.1021/np9002433DOI Listing
July 2009

Autophagy and cancer: dynamism of the metabolism of tumor cells and tissues.

Cancer Lett 2009 Jun 11;278(2):130-138. Epub 2008 Nov 11.

Cancer Physiology Project, Research Center for Innovative oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba 277-8577, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2008.09.040DOI Listing
June 2009

Quantitative metabolome profiling of colon and stomach cancer microenvironment by capillary electrophoresis time-of-flight mass spectrometry.

Cancer Res 2009 Jun 19;69(11):4918-25. Epub 2009 May 19.

Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata, Japan and National Cancer Center Hospital East, Kashiwa, Chiba, Japan.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-4806DOI Listing
June 2009

Provision of a voluntary exercise environment enhances running activity and prevents obesity in Snark-deficient mice.

Am J Physiol Endocrinol Metab 2009 May 10;296(5):E1013-21. Epub 2009 Mar 10.

Graduate School of Health and Sports Science, Juntendo University, Inba, Chiba 270-1695, Japan.

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http://dx.doi.org/10.1152/ajpendo.90891.2008DOI Listing
May 2009

Massive transcriptional start site analysis of human genes in hypoxia cells.

Nucleic Acids Res 2009 Apr 22;37(7):2249-63. Epub 2009 Feb 22.

Cancer Physiology Project, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.

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http://dx.doi.org/10.1093/nar/gkp066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673422PMC
April 2009

Impact of inducible nitric oxide synthase gene on tumor progression.

Eur J Cancer Prev 2009 Feb;18(1):1-8

Department of Hygiene and Preventive Medicine, School of Medicine, Showa University, Tokyo, Japan.

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https://insights.ovid.com/crossref?an=00008469-200902000-000
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http://dx.doi.org/10.1097/CEJ.0b013e3282f75f29DOI Listing
February 2009

Nuclear localization of SNARK; its impact on gene expression.

Biochem Biophys Res Commun 2008 Dec 6;377(4):1062-6. Epub 2008 Nov 6.

Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba 277-8561, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2008.10.143DOI Listing
December 2008

Autophagy is activated in pancreatic cancer cells and correlates with poor patient outcome.

Cancer Sci 2008 Sep 4;99(9):1813-9. Epub 2008 Jul 4.

Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba 277-8577, Japan.

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http://dx.doi.org/10.1111/j.1349-7006.2008.00893.xDOI Listing
September 2008

Novel anticancer agents, kayeassamins C-I from the flower of Kayea assamica of Myanmar.

Bioorg Med Chem 2008 Sep 6;16(18):8653-60. Epub 2008 Aug 6.

Institute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama 930-0194, Japan.

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http://dx.doi.org/10.1016/j.bmc.2008.07.091DOI Listing
September 2008

Novel anticancer agents, kayeassamins A and B from the flower of Kayea assamica of Myanmar.

Bioorg Med Chem Lett 2008 Aug 4;18(16):4688-91. Epub 2008 Jul 4.

Institute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama 930-0194, Japan.

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http://dx.doi.org/10.1016/j.bmcl.2008.07.001DOI Listing
August 2008

Susceptibility of Snark-deficient mice to azoxymethane-induced colorectal tumorigenesis and the formation of aberrant crypt foci.

Cancer Sci 2008 Apr 27;99(4):677-82. Epub 2007 Feb 27.

Cancer Physiology Project, Research Center for Innovative Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba 277-8577, Japan.

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http://doi.wiley.com/10.1111/j.1349-7006.2008.00734.x
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http://dx.doi.org/10.1111/j.1349-7006.2008.00734.xDOI Listing
April 2008

Panduratins D-I, novel secondary metabolites from rhizomes of Boesenbergia pandurata.

Chem Pharm Bull (Tokyo) 2008 Apr;56(4):491-6

Institute of Natural Medicine, University of Toyama, Toyoma, Japan.

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http://dx.doi.org/10.1248/cpb.56.491DOI Listing
April 2008

Induction of necrosis in human myeloma cells by kigamicin.

Anticancer Res 2008 Jan-Feb;28(1A):37-43

Department of Hematology, Kumamoto University Hospital, Kumamoto, Japan.

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April 2008

c-Maf expression in angioimmunoblastic T-cell lymphoma.

Am J Surg Pathol 2007 Nov;31(11):1695-702

Department of Pathology of Biological Response, Nagoya University Graduate School of Medicine, Tsurumai-cho 65, Showa-ku, Japan.

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http://dx.doi.org/10.1097/PAS.0b013e318054dbcfDOI Listing
November 2007

Hypoxic regulation of PFKFB-3 and PFKFB-4 gene expression in gastric and pancreatic cancer cell lines and expression of PFKFB genes in gastric cancers.

Acta Biochim Pol 2006 4;53(4):789-99. Epub 2006 Dec 4.

Department of Molecular Biology, Palladin Institute of Biochemistry, National Academy of Science of Ukraine, Kyiv, Ukraine.

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October 2007

Bioactive secondary metabolites from Boesenbergia pandurata of Myanmar and their preferential cytotoxicity against human pancreatic cancer PANC-1 cell line in nutrient-deprived medium.

J Nat Prod 2007 Oct 27;70(10):1582-7. Epub 2007 Sep 27.

Institute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama 930-0194, Japan.

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http://dx.doi.org/10.1021/np070286mDOI Listing
October 2007

Autophagy is activated in colorectal cancer cells and contributes to the tolerance to nutrient deprivation.

Cancer Res 2007 Oct;67(20):9677-84

Cancer Physiology Project and Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Chiba, and Department of Surgery, Kyorin University School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-1462DOI Listing
October 2007

Phenotypic reversion in analbuminemic rats due to an altered splicing mechanism.

Proc Jpn Acad Ser B Phys Biol Sci 2007 May;83(4):101-9

Research Center for Innovative Oncology, National Cancer Center Hospital East, Chiba, Japan .

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756734PMC
http://dx.doi.org/10.2183/pjab.83.101DOI Listing
May 2007

Diterpenes from "Pini Resina" and their preferential cytotoxic activity under nutrient-deprived condition.

Planta Med 2006 Oct 10;72(13):1231-4. Epub 2006 Aug 10.

Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-2006-947189
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http://dx.doi.org/10.1055/s-2006-947189DOI Listing
October 2006

Expression and hypoxia-responsiveness of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 in mammary gland malignant cell lines.

Acta Biochim Pol 2005 11;52(4):881-8. Epub 2005 Jul 11.

Palladin Institute of Biochemistry, National Academy of Science of Ukraine, Kyiv, Ukraine.

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July 2006

NDR2 acts as the upstream kinase of ARK5 during insulin-like growth factor-1 signaling.

J Biol Chem 2006 May 17;281(20):13915-21. Epub 2006 Feb 17.

Division of Endocrinology and Metabolism, Department of Developmental Physiology, National Institute for Physiological Sciences, 38 Nishigonaka, Myodaiji, Okazaki, Aichi 444-8585, Japan.

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http://dx.doi.org/10.1074/jbc.M511354200DOI Listing
May 2006

[AMPK in the cancer research field: tumor progression by ARK5].

Seikagaku 2006 May;78(5):392-403

National Institute for Physiological Sciences, Division of Endocrinology and Metabolism, 38 Nishigonaka Myodaiji, Okazaki, Aichi 444-8585, Japan.

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May 2006

Antitumor effect of kigamicin D on mouse tumor models.

J Antibiot (Tokyo) 2006 Apr;59(4):209-14

Numazu Bio-Medical Research Institute, Microbial Chemistry Research Center, 18-24 Miyamoto, Numazu-shi, Shizuoka 410-0301, Japan.

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http://dx.doi.org/10.1038/ja.2006.29DOI Listing
April 2006

Angelmarin, a novel anti-cancer agent able to eliminate the tolerance of cancer cells to nutrient starvation.

Bioorg Med Chem Lett 2006 Feb 8;16(3):581-3. Epub 2005 Nov 8.

Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan.

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http://dx.doi.org/10.1016/j.bmcl.2005.10.046DOI Listing
February 2006

A pull-down assay for 5' AMP-activated protein kinase activity using the GST-fused protein.

Mol Biotechnol 2006 Jan;32(1):17-21

Cancer Physiology Project, National Cancer Center Research Institute East, 6-5-1 Kashiwanoha, Kashiwa, Chiba 277-8577, Japan.

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http://dx.doi.org/10.1385/MB:32:1:017DOI Listing
January 2006

Overexpression of c-Maf contributes to T-cell lymphoma in both mice and human.

Cancer Res 2006 Jan;66(2):812-9

Department of Anatomy and Embryology, Biomolecular and Integrated Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Japan.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-2154DOI Listing
January 2006

Muscle contractions, AICAR, and insulin cause phosphorylation of an AMPK-related kinase.

Am J Physiol Endocrinol Metab 2005 Dec 19;289(6):E986-92. Epub 2005 Jul 19.

Dept. of Biology, Saint Louis University, 3507 Laclede Avenue, St. Louis, MO 63103, USA.

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http://dx.doi.org/10.1152/ajpendo.00335.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1350986PMC
December 2005

Splice isoform of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-4: expression and hypoxic regulation.

Mol Cell Biochem 2005 Dec;280(1-2):227-34

Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, 9 Leontovycha Street, Kyiv, 01601, Ukraine.

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http://link.springer.com/10.1007/s11010-005-8009-6
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December 2005

Involvement of transforming growth factor-beta 1 signaling in hypoxia-induced tolerance to glucose starvation.

J Biol Chem 2005 Sep 13;280(36):31557-63. Epub 2005 Jul 13.

Cancer Physiology Project, National Cancer Center Research Institute East, 6-5-1 Kashiwanoha, Kashiwa, Chiba 277-8577, Japan.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M503714200
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September 2005

Role of nitric oxide (NO) in interferon-alpha therapy for hepatitis C.

J Infect 2005 Jul;51(1):47-53

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Jikei University School of Medicine, 3-25-8 Nishishimbashi, Minato, Tokyo 105-0003, Japan.

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http://dx.doi.org/10.1016/j.jinf.2004.08.025DOI Listing
July 2005

Risk of multiple squamous cell carcinomas both in the esophagus and the head and neck region.

Carcinogenesis 2005 May 17;26(5):1008-12. Epub 2005 Feb 17.

Division of Digestive Endoscopy and Gastrointestinal Oncology, National Cancer Center Hospital East, 6-5-1 kashiwanoha Kashiwa, 277-8577 Japan.

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http://carcin.oxfordjournals.org/content/26/5/1008.full.pdf
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http://www.carcin.oupjournals.org/cgi/doi/10.1093/carcin/bgi
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http://dx.doi.org/10.1093/carcin/bgi035DOI Listing
May 2005

Molecular analysis of the TSC1 gene in adenocarcinoma of the lung.

Lung Cancer 2004 Dec;46(3):271-81

Investigative Treatment Division, National Cancer Center Research Institute East, 6-5-1, Kashiwanoha, Kashiwa, Chiba 277 8577, Japan.

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http://dx.doi.org/10.1016/j.lungcan.2004.05.001DOI Listing
December 2004

IGF-1 phosphorylates AMPK-alpha subunit in ATM-dependent and LKB1-independent manner.

Biochem Biophys Res Commun 2004 Nov;324(3):986-92

Cancer Physiology Project, National Cancer Center Research Institute East, 6-5-1 Kashiwanoha, Kashiwa, Chiba 277-8577, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2004.09.145DOI Listing
November 2004

Hypoxia induces transcription of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-4 gene via hypoxia-inducible factor-1alpha activation.

FEBS Lett 2004 Oct;576(1-2):14-20

Department of Molecular Biology, Palladin Institute of Biochemistry, National Academy of Science of Ukraine, Kyiv 01601, Ukraine.

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http://dx.doi.org/10.1016/j.febslet.2004.08.053DOI Listing
October 2004

Regulation of caspase-6 and FLIP by the AMPK family member ARK5.

Oncogene 2004 Sep;23(42):7067-75

Investigative Treatment Division, National Cancer Center Research Institute East, 6-5-1 Kashiwanoha, Kashiwa, Chiba 277-8577, Japan.

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http://dx.doi.org/10.1038/sj.onc.1207963DOI Listing
September 2004

Squamous cell carcinoma in situ at oropharyngeal and hypopharyngeal mucosal sites.

Cancer 2004 Sep;101(6):1375-81

Division of Digestive Endoscopy and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwanoha, Kashiwa, Japan.

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http://doi.wiley.com/10.1002/cncr.20482
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September 2004

Nitric oxide as an endogenous mutagen for Sendai virus without antiviral activity.

J Virol 2004 Aug;78(16):8709-19

Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556, Japan.

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http://dx.doi.org/10.1128/JVI.78.16.8709-8719.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC479088PMC
August 2004

Antitumor activity of pyrvinium pamoate, 6-(dimethylamino)-2-[2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethenyl]-1-methyl-quinolinium pamoate salt, showing preferential cytotoxicity during glucose starvation.

Cancer Sci 2004 Aug;95(8):685-90

Investigative Treatment Division, National Cancer Center Research Institute East, Kashiwa, Chiba 277-8577, Japan.

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http://dx.doi.org/10.1111/j.1349-7006.2004.tb03330.xDOI Listing
August 2004

Kigamicin D, a novel anticancer agent based on a new anti-austerity strategy targeting cancer cells' tolerance to nutrient starvation.

Cancer Sci 2004 Jun;95(6):547-52

Investigative Treatment Division, National Cancer Center Research Institute East, Chiba 277-8577, Japan.

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http://dx.doi.org/10.1111/j.1349-7006.2004.tb03247.xDOI Listing
June 2004

Analysis of promoter region of X-linked pgk-1 gene polymorphisms: evidence for polyclonality of adult mouse gastric glands.

Dig Dis Sci 2004 Feb;49(2):218-23

Department of Gastrointestinal Surgery, Graduate School of Medicine, University of Tokyo, Tokyo 113-8655, Japan.

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http://dx.doi.org/10.1023/b:ddas.0000017441.06479.c8DOI Listing
February 2004