Hirotsugu Kenmotsu

Hirotsugu Kenmotsu

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Hirotsugu Kenmotsu

Hirotsugu Kenmotsu

Publications by authors named "Hirotsugu Kenmotsu"

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100Publications

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Evaluation of gefitinib systemic exposure in EGFR-mutated non-small cell lung cancer patients with gefitinib-induced severe hepatotoxicity.

Cancer Chemother Pharmacol 2020 Feb 10. Epub 2020 Feb 10.

Department of Clinical Pharmacokinetics and Pharmacodynamics, Keio University School Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.

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http://dx.doi.org/10.1007/s00280-020-04034-yDOI Listing
February 2020

Acquired immunodeficiency associated with thymoma: a case report.

BMC Cancer 2019 Aug 2;19(1):762. Epub 2019 Aug 2.

Division of Thoracic Oncology, Shizuoka Cancer Center Hospital, 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka, 411-8777, Japan.

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http://dx.doi.org/10.1186/s12885-019-5980-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679538PMC
August 2019

Leptomeningeal recurrence after long-term alectinib therapy for non-small cell lung cancer harboring an EML4-ALK fusion protein.

Invest New Drugs 2019 02 3;37(1):184-187. Epub 2018 Jul 3.

Division of Thoracic Oncology, Shizuoka Cancer Center Hospital, 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka, 411-8777, Japan.

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http://dx.doi.org/10.1007/s10637-018-0633-6DOI Listing
February 2019

Changes in programmed death ligand 1 expression in non-small cell lung cancer patients who received anticancer treatments.

Int J Clin Oncol 2018 Dec 15;23(6):1052-1059. Epub 2018 Jun 15.

Division of Thoracic Oncology, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi-cho, Suntou-gun, Shizuoka, Shizuoka, 411-8777, Japan.

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http://dx.doi.org/10.1007/s10147-018-1305-4DOI Listing
December 2018

Efficacy of second-line chemotherapy in poor-risk patients with refractory-relapsed small-cell lung cancer.

Jpn J Clin Oncol 2018 Sep;48(9):822-826

Division of Thoracic Oncology, Shizuoka Cancer Center, Nagaizumi-cho, Suntou-gun, Shizuoka, Japan.

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http://dx.doi.org/10.1093/jjco/hyy107DOI Listing
September 2018

[Pneumonitis Induced by Immune Checkpoint Inhibitors].

Gan To Kagaku Ryoho 2018 Jul;45(7):1021-1026

Division of Thoracic Oncology, Shizuoka Cancer Center.

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July 2018

Chemotherapy-induced cardiomyopathy caused by Pemetrexed.

Invest New Drugs 2018 02 28;36(1):147-150. Epub 2017 Jun 28.

Division of Pathology, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka, 411-8777, Japan.

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http://dx.doi.org/10.1007/s10637-017-0485-5DOI Listing
February 2018

CYFRA 21-1 predicts the efficacy of nivolumab in patients with advanced lung adenocarcinoma.

Tumour Biol 2018 Feb;40(2):1010428318760420

1 Division of Thoracic Oncology, Shizuoka Cancer Center, Sunto-gun, Nagaizumi-cho, Shizuoka, Japan.

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http://dx.doi.org/10.1177/1010428318760420DOI Listing
February 2018

Successful osimertinib rechallenge in a patient with advanced non-small cell lung cancer following osimertinib-induced interstitial lung disease after treatment with nivolumab.

Invest New Drugs 2017 12 2;35(6):839-841. Epub 2017 May 2.

Division of Thoracic Oncology, Shizuoka Cancer Center Hospital, 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka, 411-8777, Japan.

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http://dx.doi.org/10.1007/s10637-017-0471-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5694521PMC
December 2017

Survival data for postoperative adjuvant chemotherapy comprising cisplatin plus vinorelbine after complete resection of non-small cell lung cancer.

Cancer Chemother Pharmacol 2017 Sep 31;80(3):609-614. Epub 2017 Jul 31.

Division of Thoracic Oncology, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka, 411-8777, Japan.

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http://dx.doi.org/10.1007/s00280-017-3400-zDOI Listing
September 2017

Response to the treatment immediately before nivolumab monotherapy may predict clinical response to nivolumab in patients with non-small cell lung cancer.

Int J Clin Oncol 2017 Aug 5;22(4):690-697. Epub 2017 Apr 5.

Division of Thoracic Oncology, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi-cho Sunto-gun, Shizuoka, 411-8777, Japan.

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http://dx.doi.org/10.1007/s10147-017-1118-xDOI Listing
August 2017

Osimertinib-induced interstitial lung disease after treatment with anti-PD1 antibody.

Invest New Drugs 2017 02 6;35(1):105-107. Epub 2016 Sep 6.

Division of Thoracic Oncology, Shizuoka Cancer Center Hospital, 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka, 411-8777, Japan.

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http://dx.doi.org/10.1007/s10637-016-0389-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5306260PMC
February 2017

The efficacy of amrubicin on central nervous system metastases originating from small-cell lung cancer: a case series of eight patients.

Invest New Drugs 2015 Jun 7;33(3):755-60. Epub 2015 Apr 7.

Department of Thoracic Oncology, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka, 411-8777, Japan,

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http://dx.doi.org/10.1007/s10637-015-0233-7DOI Listing
June 2015

Pharmacokinetics, dynamics and toxicity of docetaxel: Why the Japanese dose differs from the Western dose.

Cancer Sci 2015 May 25;106(5):497-504. Epub 2015 Mar 25.

Department of Clinical Pharmacokinetics and Pharmacodynamics, Keio University School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1111/cas.12647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452149PMC
May 2015

Effect of platinum-based chemotherapy for non-small cell lung cancer patients with interstitial lung disease.

Cancer Chemother Pharmacol 2015 Mar 7;75(3):521-6. Epub 2015 Jan 7.

Division of Thoracic Oncology, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka, 411-8777, Japan,

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http://dx.doi.org/10.1007/s00280-014-2670-yDOI Listing
March 2015

Disease flare after gefitinib discontinuation.

Respir Investig 2015 Mar 13;53(2):68-72. Epub 2014 Nov 13.

Division of Thoracic Oncology, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi-cho Sunto-gun, Shizuoka 411-8777, Japan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22125345140011
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http://dx.doi.org/10.1016/j.resinv.2014.10.005DOI Listing
March 2015

Efficacy of rechallenge chemotherapy in patients with sensitive relapsed small cell lung cancer.

Am J Clin Oncol 2015 Feb;38(1):28-32

Divisions of *Thoracic Oncology †Diagnostic Radiology ‡Pathology, Shizuoka Cancer Center Hospital, Nagaizumi-cho, Suntou-gun, Shizuoka, Japan.

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http://dx.doi.org/10.1097/COC.0b013e318286907bDOI Listing
February 2015

Current status and future perspectives of cooperative study groups for lung cancer in Japan.

Respir Investig 2014 Nov 24;52(6):339-47. Epub 2014 Jul 24.

Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan; Center for Clinical and Translational Research, Kyushu University Hospital, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan; West Japan Oncology Group (WJOG), Japan; Lung Oncology Group in Kyushu (LOGiK), Japan. Electronic address:

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http://dx.doi.org/10.1016/j.resinv.2014.06.004DOI Listing
November 2014

Identification of actionable mutations in malignant pleural mesothelioma.

Lung Cancer 2014 Oct 18;86(1):35-40. Epub 2014 Aug 18.

Drug Discovery and Development Division, Shizuoka Cancer Center Research Institute, 1007 Shimonagakubo, Nagaizumi-cho, Suntou-gun, Shizuoka 411-8777, Japan; Third Department of Internal Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama-shi, Wakayama 641-8509, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.lungcan.2014.08.004DOI Listing
October 2014

Multiplexed molecular profiling of lung cancer using pleural effusion.

J Thorac Oncol 2014 Jul;9(7):1048-52

*Division of Thoracic Oncology, Shizuoka Cancer Center, Shimonagakubo; †Division of Drug Discovery and Development, Shizuoka Cancer Center Research Institute, Nagaizumi-cho, Sunto-gun, Shizuoka; ‡Third Department of Internal Medicine, Wakayama Medical University, Kimiidera, Wakayama; §Departments of Thoracic Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari-ku, Osaka; ‖Clinical Trial Management Department, Shizuoka Cancer Center, Shimonagakubo, Nagaizumi-cho Sunto-gun, Shizuoka; ¶Department of Respiratory Medicine, Juntendo University, Tokyo; #Division of Thoracic Surgery; **Division of Diagnostic Radiology; and ††Division of Diagnostic Pathology, Shizuoka Cancer Center, Shimonagakubo, Nagaizumi-cho Sunto-gun, Shizuoka, Japan.

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http://dx.doi.org/10.1097/JTO.0000000000000203DOI Listing
July 2014

Molecular profiling of small cell lung cancer in a Japanese cohort.

Lung Cancer 2014 May 3;84(2):139-44. Epub 2014 Mar 3.

Division of Thoracic Oncology, Shizuoka Cancer Center, Nagaizumi-cho, Suntou-gun, Shizuoka, Japan; Third Department of Internal Medicine, Wakayama Medical University, Kimiidera, Wakayama, Japan.

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http://dx.doi.org/10.1016/j.lungcan.2014.02.013DOI Listing
May 2014

Assessment of mutational profile of Japanese lung adenocarcinoma patients by multitarget assays: a prospective, single-institute study.

Cancer 2014 May 3;120(10):1471-81. Epub 2014 Apr 3.

Division of Thoracic Oncology, Shizuoka Cancer Center, Shizuoka, Japan; Drug Discovery and Development Division, Shizuoka Cancer Center Research Institute, Shizuoka, Japan.

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http://dx.doi.org/10.1002/cncr.28604DOI Listing
May 2014

Toxicity and efficacy of chemotherapy for non-small cell lung cancer with cavitary lesions.

Respir Investig 2014 May 17;52(3):184-9. Epub 2014 Jan 17.

Division of Thoracic Oncology, Shizuoka Cancer Center, Nagaizumi-cho, Sunto-gun, Japan; Third Department of Internal Medicine, Wakayama Medical University, Kimiidera, Wakayama, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.resinv.2013.12.004DOI Listing
May 2014

A Phase III trial comparing irinotecan and cisplatin with etoposide and cisplatin in adjuvant chemotherapy for completely resected pulmonary high-grade neuroendocrine carcinoma (JCOG1205/1206).

Jpn J Clin Oncol 2014 Apr 27;44(4):379-82. Epub 2014 Jan 27.

*Division of Thoracic Oncology, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka 411-8777, Japan.

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http://dx.doi.org/10.1093/jjco/hyt233DOI Listing
April 2014

Prognostic impact of 18F-FDG uptake on PET in non-small cell lung cancer patients with postoperative recurrence following platinum-based chemotherapy.

Respir Investig 2014 Mar 24;52(2):121-8. Epub 2013 Oct 24.

Division of Thoracic Oncology, Shizuoka Cancer Center, 1007 Shimonagakubo Nagaizumi-cho, Sunto-gun, Shizuoka 411-8777, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.resinv.2013.08.008DOI Listing
March 2014

A feasibility study of carboplatin plus irinotecan treatment for elderly patients with extensive disease small-cell lung cancer.

Jpn J Clin Oncol 2014 Feb 13;44(2):116-21. Epub 2013 Dec 13.

*Department of Respiratory Medicine and Medical Oncology, Yokohama Municipal Citizen's Hospital, 56 Okazawa-cho, Hodogaya-ku, Yokohama, Kanagawa 240-8555, Japan.

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https://academic.oup.com/jjco/article-lookup/doi/10.1093/jjc
Publisher Site
http://dx.doi.org/10.1093/jjco/hyt195DOI Listing
February 2014

The role of βIII-tubulin in non-small cell lung cancer patients treated by taxane-based chemotherapy.

Int J Clin Oncol 2013 Jun 23;18(3):371-9. Epub 2012 Feb 23.

Division of Thoracic Oncology, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka, 411-8777, Japan.

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http://dx.doi.org/10.1007/s10147-012-0386-8DOI Listing
June 2013

Efficacy of bevacizumab-containing chemotherapy for non-squamous non-small cell lung cancer with bone metastases.

Cancer Chemother Pharmacol 2013 Jun 27;71(6):1493-8. Epub 2013 Mar 27.

Division of Thoracic Oncology, Shizuoka Cancer Center Hospital, 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka 411-8777, Japan.

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http://dx.doi.org/10.1007/s00280-013-2148-3DOI Listing
June 2013

Large cell neuroendocrine carcinoma of the lung: is it possible to diagnose from biopsy specimens?

Jpn J Clin Oncol 2013 Mar 3;43(3):294-304. Epub 2013 Feb 3.

Division of Diagnostic Pathology, Shizuoka Cancer Center, 1007 Shimonagakubo Nagaizumi, Shizuoka, Japan.

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http://dx.doi.org/10.1093/jjco/hys221DOI Listing
March 2013

Chemoradiotherapy for limited-disease small-cell lung cancer in elderly patients aged 75 years or older.

Jpn J Clin Oncol 2013 Feb 5;43(2):176-83. Epub 2012 Dec 5.

Division of Thoracic Oncology, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi-chou, Suntou-gun, Shizuoka 411-8777, Japan.

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http://dx.doi.org/10.1093/jjco/hys197DOI Listing
February 2013

Prognostic factors and clinical outcome of patients with lung adenocarcinoma with carcinomatous meningitis.

Anticancer Res 2012 May;32(5):1811-6

Division of Thoracic Oncology, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi-chou, Suntou-gun, Shizuoka, 411-8777, Japan.

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May 2012