Publications by authors named "Hirotaka Watada"

100Publications

Left atrial dysfunction and stiffness in pediatric and adult patients with Type 1 diabetes mellitus assessed with speckle tracking echocardiography.

Pediatr Diabetes 2020 Oct 22. Epub 2020 Oct 22.

Department of Pediatrics and Adolescent Medicine, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan.

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http://dx.doi.org/10.1111/pedi.13141DOI Listing
October 2020

Current understanding of the effect of sodium-glucose co-transporter-2 inhibitors in Asian patients with diabetes mellitus.

Authors:
Hirotaka Watada

Diabetol Int 2020 Jul 8;11(3):242-244. Epub 2020 Jun 8.

Department of Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421 Japan.

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http://dx.doi.org/10.1007/s13340-020-00443-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387392PMC
July 2020

Rubicon in pancreatic beta cells plays a limited role in maintaining glucose homeostasis following increased insulin resistance.

Endocr J 2020 Nov 16;67(11):1119-1126. Epub 2020 Jul 16.

Department of Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan.

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http://dx.doi.org/10.1507/endocrj.EJ20-0326DOI Listing
November 2020

Fasting serum free glycerol concentration is a potential surrogate marker of visceral obesity and insulin sensitivity in middle-aged Japanese men.

J Clin Lipidol 2020 Jul - Aug;14(4):522-530. Epub 2020 Jun 9.

Department of Clinical Laboratory Medicine, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan; Sportology Center, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.jacl.2020.06.003DOI Listing
June 2020

Lower intake of saturated fatty acids is associated with persistently higher arterial stiffness in patients with type 2 diabetes.

J Diabetes Investig 2020 Jul 6. Epub 2020 Jul 6.

Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1111/jdi.13347DOI Listing
July 2020

Plasma glucagon levels measured by sandwich ELISA are correlated with impaired glucose tolerance in type 2 diabetes.

Endocr J 2020 Sep 23;67(9):903-922. Epub 2020 May 23.

Metabolic Signal Research Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma, Japan.

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http://dx.doi.org/10.1507/endocrj.EJ20-0079DOI Listing
September 2020

Clinical evidence regarding factors linking metabolic abnormal obesity to pancreatic β-cell dysfunction.

Authors:
Hirotaka Watada

J Diabetes Investig 2020 Jul 13;11(4):798-800. Epub 2020 May 13.

Department of Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1111/jdi.13264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378415PMC
July 2020

A chronic high-fat diet exacerbates contractile dysfunction with impaired intracellular Ca release capacity in the skeletal muscle of aged mice.

J Appl Physiol (1985) 2020 May 26;128(5):1153-1162. Epub 2020 Mar 26.

Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1152/japplphysiol.00530.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276930PMC
May 2020

Breakfast skipping is associated with persistently increased arterial stiffness in patients with type 2 diabetes.

BMJ Open Diabetes Res Care 2020 02;8(1)

Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, Bunkyo-ku, Japan.

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http://dx.doi.org/10.1136/bmjdrc-2019-001162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206922PMC
February 2020

Conversion of pancreatic α cells into insulin-producing cells modulated by β-cell insufficiency and supplemental insulin administration.

Biochem Biophys Res Commun 2020 01 22;521(1):178-183. Epub 2019 Oct 22.

Department of Metabolism and Endocrinology, Japan; Center for Identification of Diabetic Therapeutic Targets, Japan; Center for Therapeutic Innovations in Diabetes, Juntendo University Graduate School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2019.10.100DOI Listing
January 2020

Cellular Autophagy in Cells Plays a Role in the Maintenance of Islet Architecture.

J Endocr Soc 2019 Nov 8;3(11):1979-1992. Epub 2019 Aug 8.

Department of Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1210/js.2019-00075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6786006PMC
November 2019

Evidence-based comparison of glucagon-like peptide receptor agonists and sodium-glucose cotransporter 2 inhibitors.

Authors:
Hirotaka Watada

J Diabetes Investig 2020 01 17;11(1):17-19. Epub 2019 Sep 17.

Department of Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1111/jdi.13131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944817PMC
January 2020

Establishment of a system for screening autophagic flux regulators using a modified fluorescent reporter and CRISPR/Cas9.

Biochem Biophys Res Commun 2019 08 26;516(3):686-692. Epub 2019 Jun 26.

Department of Endocrinology and Metabolism, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan; Center for Therapeutic Innovations in Diabetes, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan; Center for Identification of Diabetic Therapeutic Targets, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2019.06.129DOI Listing
August 2019

Development of monoclonal mouse antibodies that specifically recognize pancreatic polypeptide.

Endocr J 2019 May 6;66(5):459-468. Epub 2019 Mar 6.

Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan.

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http://dx.doi.org/10.1507/endocrj.EJ18-0441DOI Listing
May 2019

The Effect of Linagliptin versus Metformin Treatment-Related Quality of Life in Patients with Type 2 Diabetes Mellitus.

Diabetes Ther 2019 Feb 27;10(1):119-134. Epub 2018 Nov 27.

Department of Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan.

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http://dx.doi.org/10.1007/s13300-018-0539-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349297PMC
February 2019

Defective autophagy in vascular smooth muscle cells enhances atherosclerotic plaque instability.

Biochem Biophys Res Commun 2018 11 11;505(4):1141-1147. Epub 2018 Oct 11.

Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan; Center for Therapeutic Innovations in Diabetes, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan; Center for Identification of Diabetic Therapeutic Targets, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2018.09.192DOI Listing
November 2018

Suppression of STAT3 signaling promotes cellular reprogramming into insulin-producing cells induced by defined transcription factors.

EBioMedicine 2018 Oct 25;36:358-366. Epub 2018 Sep 25.

Department of Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan; Center for Identification of Diabetic Therapeutic Targets, Juntendo University Graduate School of Medicine, Tokyo, Japan; Sportology Center, Juntendo University Graduate School of Medicine, Tokyo, Japan; Center for Molecular Diabetology, Juntendo University Graduate School of Medicine, Tokyo, Japan.

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https://linkinghub.elsevier.com/retrieve/pii/S23523964183039
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http://dx.doi.org/10.1016/j.ebiom.2018.09.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197741PMC
October 2018

Defective autophagy in vascular smooth muscle cells enhances cell death and atherosclerosis.

Autophagy 2018 10;14(11):1991-2006. Epub 2018 Aug 10.

a Department of Metabolism & Endocrinology , Juntendo University Graduate School of Medicine , 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421 , Japan.

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http://dx.doi.org/10.1080/15548627.2018.1501132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152523PMC
October 2019

Guidelines for clinical evaluation of chronic kidney disease : AMED research on regulatory science of pharmaceuticals and medical devices.

Clin Exp Nephrol 2018 Dec;22(6):1446-1475

Division of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

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http://dx.doi.org/10.1007/s10157-018-1615-xDOI Listing
December 2018

Everolimus Directly Suppresses Insulin Secretion Independently of Cell Growth Inhibition.

J Endocr Soc 2018 Jul 22;2(7):589-596. Epub 2018 May 22.

Department of Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1210/js.2017-00475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007247PMC
July 2018

Study Protocol for the Initial Choice of DPP-4 Inhibitor in Japanese Patients with Type 2 diabetes Mellitus: Effect of Linagliptin on QOL (INTEL-QOL) Trial.

Diabetes Ther 2018 Jun 9;9(3):1403-1412. Epub 2018 May 9.

Department of Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan.

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http://dx.doi.org/10.1007/s13300-018-0437-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984940PMC
June 2018

Enhanced Expression of the Key Mitosis Regulator Cyclin B1 Is Mediated by PDZ-Binding Kinase in Islets of Pregnant Mice.

J Endocr Soc 2018 Mar 30;2(3):207-219. Epub 2018 Jan 30.

Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan.

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http://dx.doi.org/10.1210/js.2017-00338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841183PMC
March 2018

Heterogeneity of autophagic status in pancreatic β cells under metabolic stress.

Biochem Biophys Res Commun 2018 02 11;496(2):328-334. Epub 2018 Jan 11.

Department of Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan; Center for Identification of Diabetic Therapeutic Targets, Juntendo University Graduate School of Medicine, Tokyo, Japan; Center for Therapeutic Innovations in Diabetes, Juntendo University Graduate School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2018.01.070DOI Listing
February 2018

Evaluation of the Effect of Alogliptin on Tissue Characteristics of the Carotid Wall: Subanalysis of the SPEAD-A Trial.

Diabetes Ther 2018 Feb 12;9(1):317-329. Epub 2018 Jan 12.

Department of Metabolic Medicine, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan.

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http://dx.doi.org/10.1007/s13300-018-0367-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801253PMC
February 2018

Normal pancreatic β-cell function in mice with RIP-Cre-mediated inactivation of p62/SQSTM1.

Endocr J 2018 Jan 4;65(1):83-89. Epub 2017 Oct 4.

Department of Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan.

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http://dx.doi.org/10.1507/endocrj.EJ17-0333DOI Listing
January 2018

Type 2 Diabetes and Bacteremia.

Ann Nutr Metab 2017 28;71 Suppl 1:17-22. Epub 2017 Sep 28.

Department of Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1159/000479919DOI Listing
May 2018

Dose-Dependent Effect of Sitagliptin on Carotid Atherosclerosis in Patients with Type 2 Diabetes Mellitus Receiving Insulin Treatment: A Post Hoc Analysis.

Diabetes Ther 2017 Oct 20;8(5):1135-1146. Epub 2017 Sep 20.

Department of Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Hongo 2-1-1, Bunkyo-ku, Tokyo, 113-8421, Japan.

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http://dx.doi.org/10.1007/s13300-017-0309-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630563PMC
October 2017