Hirotaka Watada

Hirotaka Watada

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Hirotaka Watada

Publications by authors named "Hirotaka Watada"

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Cellular Autophagy in Cells Plays a Role in the Maintenance of Islet Architecture.

J Endocr Soc 2019 Nov 8;3(11):1979-1992. Epub 2019 Aug 8.

Department of Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1210/js.2019-00075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6786006PMC
November 2019

Defective autophagy in vascular smooth muscle cells enhances cell death and atherosclerosis.

Autophagy 2018 10;14(11):1991-2006. Epub 2018 Aug 10.

a Department of Metabolism & Endocrinology , Juntendo University Graduate School of Medicine , 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421 , Japan.

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http://dx.doi.org/10.1080/15548627.2018.1501132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152523PMC
October 2019

Conversion of pancreatic α cells into insulin-producing cells modulated by β-cell insufficiency and supplemental insulin administration.

Biochem Biophys Res Commun 2019 Oct 22. Epub 2019 Oct 22.

Department of Metabolism and Endocrinology, Japan; Center for Identification of Diabetic Therapeutic Targets, Japan; Center for Therapeutic Innovations in Diabetes, Juntendo University Graduate School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2019.10.100DOI Listing
October 2019

Establishment of a system for screening autophagic flux regulators using a modified fluorescent reporter and CRISPR/Cas9.

Biochem Biophys Res Commun 2019 Aug 26;516(3):686-692. Epub 2019 Jun 26.

Department of Endocrinology and Metabolism, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan; Center for Therapeutic Innovations in Diabetes, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan; Center for Identification of Diabetic Therapeutic Targets, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2019.06.129DOI Listing
August 2019

Evidence-based comparison of glucagon-like peptide receptor agonists and sodium-glucose cotransporter 2 inhibitors.

Authors:
Hirotaka Watada

J Diabetes Investig 2019 Aug 25. Epub 2019 Aug 25.

Department of Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1111/jdi.13131DOI Listing
August 2019

Development of monoclonal mouse antibodies that specifically recognize pancreatic polypeptide.

Endocr J 2019 May 6;66(5):459-468. Epub 2019 Mar 6.

Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan.

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http://dx.doi.org/10.1507/endocrj.EJ18-0441DOI Listing
May 2019

The Effect of Linagliptin versus Metformin Treatment-Related Quality of Life in Patients with Type 2 Diabetes Mellitus.

Diabetes Ther 2019 Feb 27;10(1):119-134. Epub 2018 Nov 27.

Department of Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan.

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http://dx.doi.org/10.1007/s13300-018-0539-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349297PMC
February 2019

Guidelines for clinical evaluation of chronic kidney disease : AMED research on regulatory science of pharmaceuticals and medical devices.

Clin Exp Nephrol 2018 Dec;22(6):1446-1475

Division of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

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http://dx.doi.org/10.1007/s10157-018-1615-xDOI Listing
December 2018

Defective autophagy in vascular smooth muscle cells enhances atherosclerotic plaque instability.

Biochem Biophys Res Commun 2018 11 11;505(4):1141-1147. Epub 2018 Oct 11.

Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan; Center for Therapeutic Innovations in Diabetes, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan; Center for Identification of Diabetic Therapeutic Targets, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2018.09.192DOI Listing
November 2018

Suppression of STAT3 signaling promotes cellular reprogramming into insulin-producing cells induced by defined transcription factors.

EBioMedicine 2018 Oct 25;36:358-366. Epub 2018 Sep 25.

Department of Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan; Center for Identification of Diabetic Therapeutic Targets, Juntendo University Graduate School of Medicine, Tokyo, Japan; Sportology Center, Juntendo University Graduate School of Medicine, Tokyo, Japan; Center for Molecular Diabetology, Juntendo University Graduate School of Medicine, Tokyo, Japan.

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https://linkinghub.elsevier.com/retrieve/pii/S23523964183039
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http://dx.doi.org/10.1016/j.ebiom.2018.09.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197741PMC
October 2018

Everolimus Directly Suppresses Insulin Secretion Independently of Cell Growth Inhibition.

J Endocr Soc 2018 Jul 22;2(7):589-596. Epub 2018 May 22.

Department of Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1210/js.2017-00475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007247PMC
July 2018

Study Protocol for the Initial Choice of DPP-4 Inhibitor in Japanese Patients with Type 2 diabetes Mellitus: Effect of Linagliptin on QOL (INTEL-QOL) Trial.

Diabetes Ther 2018 Jun 9;9(3):1403-1412. Epub 2018 May 9.

Department of Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan.

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http://dx.doi.org/10.1007/s13300-018-0437-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984940PMC
June 2018

Type 2 Diabetes and Bacteremia.

Ann Nutr Metab 2017 28;71 Suppl 1:17-22. Epub 2017 Sep 28.

Department of Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1159/000479919DOI Listing
May 2018

NEUROD1-deficient diabetes (MODY6): Identification of the first cases in Japanese and the clinical features.

Pediatr Diabetes 2018 03 30;19(2):236-242. Epub 2017 Jun 30.

Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan.

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http://dx.doi.org/10.1111/pedi.12553DOI Listing
March 2018

Enhanced Expression of the Key Mitosis Regulator Cyclin B1 Is Mediated by PDZ-Binding Kinase in Islets of Pregnant Mice.

J Endocr Soc 2018 Mar 30;2(3):207-219. Epub 2018 Jan 30.

Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan.

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http://dx.doi.org/10.1210/js.2017-00338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841183PMC
March 2018

Evaluation of the Effect of Alogliptin on Tissue Characteristics of the Carotid Wall: Subanalysis of the SPEAD-A Trial.

Diabetes Ther 2018 Feb 12;9(1):317-329. Epub 2018 Jan 12.

Department of Metabolic Medicine, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan.

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http://dx.doi.org/10.1007/s13300-018-0367-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801253PMC
February 2018

Heterogeneity of autophagic status in pancreatic β cells under metabolic stress.

Biochem Biophys Res Commun 2018 02 11;496(2):328-334. Epub 2018 Jan 11.

Department of Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan; Center for Identification of Diabetic Therapeutic Targets, Juntendo University Graduate School of Medicine, Tokyo, Japan; Center for Therapeutic Innovations in Diabetes, Juntendo University Graduate School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2018.01.070DOI Listing
February 2018

Normal pancreatic β-cell function in mice with RIP-Cre-mediated inactivation of p62/SQSTM1.

Endocr J 2018 Jan 4;65(1):83-89. Epub 2017 Oct 4.

Department of Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan.

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http://dx.doi.org/10.1507/endocrj.EJ17-0333DOI Listing
January 2018

Impaired insulin clearance as a cause rather than a consequence of insulin resistance.

J Diabetes Investig 2017 Nov 4;8(6):723-725. Epub 2017 Sep 4.

Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1111/jdi.12717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668474PMC
November 2017

Functional subdivisions of the hypothalamus using areal parcellation and their signal changes related to glucose metabolism.

Neuroimage 2017 11 24;162:1-12. Epub 2017 Aug 24.

Department of Neurophysiology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan; Sportology Center, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan; Research Institute for Diseases of Old Age, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.neuroimage.2017.08.056DOI Listing
November 2017

Lipoprotein-X in cholestatic patients causes xanthomas and promotes foam cell formation in human macrophages.

J Clin Lipidol 2017 Jan - Feb;11(1):110-118. Epub 2016 Nov 5.

Department of Clinical Laboratory Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jacl.2016.10.013DOI Listing
October 2017

Dose-Dependent Effect of Sitagliptin on Carotid Atherosclerosis in Patients with Type 2 Diabetes Mellitus Receiving Insulin Treatment: A Post Hoc Analysis.

Diabetes Ther 2017 Oct 20;8(5):1135-1146. Epub 2017 Sep 20.

Department of Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Hongo 2-1-1, Bunkyo-ku, Tokyo, 113-8421, Japan.

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http://dx.doi.org/10.1007/s13300-017-0309-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630563PMC
October 2017

A randomized controlled trial of 130 g/day low-carbohydrate diet in type 2 diabetes with poor glycemic control.

Clin Nutr 2017 08 18;36(4):992-1000. Epub 2016 Jul 18.

Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan; Center for Therapeutic Innovations in Diabetes, Juntendo University Graduate School of Medicine, Tokyo, Japan; Center for Molecular Diabetology, Juntendo University Graduate School of Medicine, Tokyo, Japan; Sportology Center, Juntendo University Graduate School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.clnu.2016.07.003DOI Listing
August 2017

Insulin lispro 25/75 and insulin lispro 50/50 as starter insulin in Japanese patients with type 2 diabetes: subanalysis of the CLASSIFY randomized trial.

Endocr J 2017 Jul 24;64(7):705-717. Epub 2017 May 24.

Medicines Development Unit Japan, Eli Lilly Japan K.K., Kobe, Japan.

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http://dx.doi.org/10.1507/endocrj.EJ17-0020DOI Listing
July 2017

Brachial-Ankle Pulse Wave Velocity and the Risk Prediction of Cardiovascular Disease: An Individual Participant Data Meta-Analysis.

Hypertension 2017 06 24;69(6):1045-1052. Epub 2017 Apr 24.

From the Department of Medicine and Clinical Science, Graduate School of Medical Sciences (T. Ohkuma), Department of Epidemiology and Public Health, Graduate School of Medical Sciences (T.N.), Innovation Center for Medical Redox Navigation (T.I.), and Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences (Y.M.), Kyushu University, Fukuoka, Japan; Department of Cardiology, Tokyo Medical University, Japan (H.T., A.Y.); Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan (K. Kario, S.H.); Faculty of Nursing Science, Tsuruga Nursing University, Japan (Y.K.); Department of Regional Resource Management, Faculty of Collaborative Regional Innovation, Ehime University, Japan (K. Kohara); Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Japan (Y.T.); Department of Internal Medicine, Iwate Medical University, Japan (Motoyuki Nakamura); Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan (T. Ohkubo); Departments of Metabolism and Endocrinology, Juntendo University, Graduate School of Medicine, Tokyo, Japan (H.W.); Research Center for Lifestyle-Related Disease, Tohoku Rosai Hospital, Sendai, Japan (M.M.); Department of Cardiovascular Medicine and Hypertension, Graduate School of Medical and Dental Sciences, Kagoshima University, Japan (M.O.); Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Japan (N.I.); Department of Cardiovascular Medicine, Cardiovascular Institute, Japan (Michinari Nakamura); Department of Vascular Medicine, Osaka City University Graduate School of Medicine, Japan (T.S.); and Hypertension and Cardiometabolic Unit, (1st) Department of Cardiology, Athens Medical School, Hippokration Hospital, Greece (C.V.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.117.09097DOI Listing
June 2017

The Influence of Sitagliptin on Treatment-Related Quality of Life in Patients with Type 2 Diabetes Mellitus Receiving Insulin Treatment: A Prespecified Sub-Analysis.

Diabetes Ther 2017 Jun 17;8(3):693-704. Epub 2017 May 17.

Department of Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Hongo 2-1-1, Bunkyo-ku, Tokyo, 113-8421, Japan.

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http://dx.doi.org/10.1007/s13300-017-0267-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446390PMC
June 2017

Relationships Among Conventional Cardiovascular Risk Factors and Lifestyle Habits With Arterial Stiffness in Type 2 Diabetic Patients.

J Clin Med Res 2017 Apr 21;9(4):297-302. Epub 2017 Feb 21.

Department of Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyoku, Tokyo 113-8421, Japan; Center for Molecular Diabetology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyoku, Tokyo 113-8421, Japan; Center for Therapeutic Innovations in Diabetes, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyoku, Tokyo 113-8421, Japan; Sportology Center, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyoku, Tokyo 113-8421, Japan.

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http://www.jocmr.org/index.php/JOCMR/article/view/2870
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http://dx.doi.org/10.14740/jocmr2870wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5330772PMC
April 2017

Efficacy and Safety of Vildagliptin as an Add-On Therapy in Inadequately Controlled Type 2 Diabetes Patients Treated With Basal Insulin.

J Clin Med Res 2017 Mar 25;9(3):193-199. Epub 2017 Jan 25.

Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan; Center for Therapeutic Innovations in Diabetes, Juntendo University Graduate School of Medicine, Tokyo, Japan; Center for Identification of Diabetic Therapeutic Targets, Juntendo University Graduate School of Medicine, Tokyo, Japan; Sportology Center, Juntendo University Graduate School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.14740/jocmr2874wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289138PMC
March 2017

Comparison of insulin lispro mix 25 with insulin lispro mix 50 as an insulin starter in Asian patients with type 2 diabetes: a phase 4, open-label, randomized trial (CLASSIFY study).

Diabetes Metab Res Rev 2017 01 14;33(1). Epub 2016 Jun 14.

Department of Endocrinology, China-Japan Friendship Hospital, Beijing, China.

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http://dx.doi.org/10.1002/dmrr.2816DOI Listing
January 2017

Comparison of the therapeutic effects of prednisolone and nonsteroidal anti-inflammatory drugs in patients with subacute thyroiditis.

Endocrine 2017 Jan 29;55(1):209-214. Epub 2016 Sep 29.

Department of Metabolism & Endocrinology, Juntendo University Graduate School, Tokyo, Japan.

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http://dx.doi.org/10.1007/s12020-016-1122-3DOI Listing
January 2017

Preserving expression of Pdx1 improves β-cell failure in diabetic mice.

Biochem Biophys Res Commun 2017 01 23;483(1):418-424. Epub 2016 Dec 23.

Department of Metabolic Medicine, Osaka University, Graduate School of Medicine, Osaka, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2016.12.128DOI Listing
January 2017

Effects of linagliptin monotherapy compared with voglibose on postprandial blood glucose responses in Japanese patients with type 2 diabetes: Linagliptin Study of Effects on Postprandial blood glucose (L-STEP).

Diabetes Res Clin Pract 2016 Nov 22;121:146-156. Epub 2016 Sep 22.

Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan; Center for Beta-Cell Biology and Regeneration, Juntendo University Graduate School of Medicine, Tokyo, Japan; Center for Therapeutic Innovations in Diabetes, Juntendo University Graduate School of Medicine, Tokyo, Japan; Center for Molecular Diabetology, Juntendo University Graduate School of Medicine, Tokyo, Japan; Sportology Center, Juntendo University Graduate School of Medicine, Tokyo, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.diabres.2016.09.014DOI Listing
November 2016

Relation Between Insulin Sensitivity and Metabolic Abnormalities in Japanese Men With BMI of 23-25 kg/m.

J Clin Endocrinol Metab 2016 10 6;101(10):3676-3684. Epub 2016 Jul 6.

Department of Metabolism & Endocrinology (K.T., Y.T., M.Ka., S.K., T.W., T.Fun. Y.Fur., H.K., R.Y., A.K., Y.Fuj., R.K., H.W.), Sportology Center (Y.T., S.K., R.Y., M.Ki., K.S., H.D., S.A., R.K., H.W.), Department of Cardiology (M.N.-Y., K.S., H.D.), Department of Radiology (S.A.), Laboratory of Proteomics and Biomolecular Science, Research Support Center (H.T., T.Fuj.), Center for Therapeutic Innovations in Diabetes (H.W.), and Center for Molecular Diabetology (H.W.), Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan; Department of Health Promotion and Exercise (S.S.S.), National Institute of Health and Nutrition, Tokyo 162-8636, Japan; and Departments of Physiology and Medicine (A.G.), Institute of Medical Science and Banting and Best Diabetes Centre, University of Toronto, Toronto, ON M5G 2C4, Canada.

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http://dx.doi.org/10.1210/jc.2016-1650DOI Listing
October 2016

Golgi membrane-associated degradation pathway in yeast and mammals.

EMBO J 2016 09 10;35(18):1991-2007. Epub 2016 Aug 10.

Department of Pathological Cell Biology, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Bunkyo-ku, Tokyo, Japan

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http://dx.doi.org/10.15252/embj.201593191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282831PMC
September 2016

Response to Comment on Mita et al. Sitagliptin Attenuates the Progression of Carotid Intima-Media Thickening in Insulin-Treated Patients With Type 2 Diabetes: The Sitagliptin Preventive Study of Intima-Media Thickness Evaluation (SPIKE): A Randomized Controlled Trial. Diabetes Care 2016;39:455-464.

Diabetes Care 2016 07;39(7):e104-5

Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan Center for Molecular Diabetology, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan Center for Therapeutic Innovations in Diabetes, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan.

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http://dx.doi.org/10.2337/dci16-0012DOI Listing
July 2016

[Large-scale clinical studies on diabetic complications].

Nihon Rinsho 2016 Apr;74 Suppl 2:33-9

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April 2016