Hirotaka Osada

Hirotaka Osada

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Hirotaka Osada

Publications by authors named "Hirotaka Osada"

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Statin suppresses Hippo pathway-inactivated malignant mesothelioma cells and blocks the YAP/CD44 growth stimulatory axis.

Cancer Lett 2017 01 20;385:215-224. Epub 2016 Oct 20.

Division of Molecular Oncology, Aichi Cancer Center Research Institute, Nagoya, Japan; Department of Cancer Genetics, Program in Function Construction Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03043835163064
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http://dx.doi.org/10.1016/j.canlet.2016.10.020DOI Listing
January 2017

Modeling mesothelioma utilizing human mesothelial cells reveals involvement of phospholipase-C beta 4 in YAP-active mesothelioma cell proliferation.

Carcinogenesis 2016 Aug 24. Epub 2016 Aug 24.

Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan, Department of Biochemistry, Aichi Medical University School of Medicine, Nagakute, Aichi 480-1195, Japan

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http://dx.doi.org/10.1093/carcin/bgw084DOI Listing
August 2016

CD74-NRG1 fusions in lung adenocarcinoma.

Cancer Discov 2014 Apr 27;4(4):415-22. Epub 2014 Jan 27.

1Department of Translational Genomics; 2Department I of Internal Medicine; 3Laboratory of Translational Cancer Genomics; 4Network Genomic Medicine, University Hospital Cologne, Center of Integrated Oncology Cologne-Bonn; 5Center for Molecular Medicine Cologne (CMMC); 6Cologne Center for Genomics (CCG); 7Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD); 8Department of Pathology, University Hospital Medical Center, University of Cologne; 9Blackfield AG; 10Max Planck Institute for Neurological Research; 11Thoracic Surgery, Lungenklinik Merheim, Kliniken der Stadt Köln gGmbH; 12Institute of Human Genetics, Cologne; 13Computational Molecular Biology Department, Max Planck Institute for Molecular Genetics, Berlin; 14Department of Prostate Cancer Research, Institute of Pathology; 15Institute for Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, Bonn; 16Institute of Pathology; 17Department of Internal Medicine II, Jena University Hospital, Friedrich-Schiller-University, Jena; 18Institute for Pathology Bad Berka, Bad Berka, Germany;19Division of Molecular Oncology, Aichi Cancer Center Research Institute; 20Department of Pathology and Molecular Diagnostics, Aichi Cancer Center, Nagoya, Japan; Departments of 21Surgery and22Pathology, St. Vincent's Hospital; 23Department of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;24Department of Pathology, 25CHU Grenoble Institut National de la Santé et de la Recherche Medicale (INSERM) U823, Institute Albert Bonniot, Grenoble-Alpes University, Grenoble, France; 26Laboratory of Oncology IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo; 27Laboratory for Molecular Medicine and Biotechnology, University Campus Bio-Medico, Rome, Italy; 28Center for the Biology of Disease, VIB, Leuven; and 29Oncology Discovery, Janssen Research and Development, A Division of Janssen Pharmaceutica NV, Beerse, Belgium.

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http://dx.doi.org/10.1158/2159-8290.CD-13-0633DOI Listing
April 2014

Hepatitis virus infection affects DNA methylation in mice with humanized livers.

Gastroenterology 2014 Feb 30;146(2):562-72. Epub 2013 Oct 30.

Division of Epigenomics, Aichi Cancer Center, Nagoya, Japan; Division of Molecular Oncology, Aichi Cancer Center, Nagoya, Japan; Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, Saitama, Japan. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2013.10.056DOI Listing
February 2014

RASSF3 downregulation increases malignant phenotypes of non-small cell lung cancer.

Lung Cancer 2014 Jan 31;83(1):23-9. Epub 2013 Oct 31.

Division of Molecular Oncology, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-ku, Nagoya 464-8681, Japan; Department of Cancer Genetics, Graduate School of Medicine, Nagoya University, Nagoya 466-8550, Japan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01695002130045
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http://dx.doi.org/10.1016/j.lungcan.2013.10.014DOI Listing
January 2014

Activation of the PI3K-AKT pathway in human malignant mesothelioma cells.

Mol Med Rep 2009 Mar-Apr;2(2):181-8

Division of Molecular Oncology, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan.

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http://dx.doi.org/10.3892/mmr_00000081DOI Listing
October 2012

NKX2-1/TITF1/TTF-1-Induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinoma.

Cancer Cell 2012 Mar;21(3):348-61

Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya 466-8550, Japan.

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http://dx.doi.org/10.1016/j.ccr.2012.02.008DOI Listing
March 2012

LATS2 is a tumor suppressor gene of malignant mesothelioma.

Cancer Res 2011 Feb 18;71(3):873-83. Epub 2011 Jan 18.

Division of Molecular Oncology, Aichi Cancer Center Research Institute, Nagoya, Japan.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-2164DOI Listing
February 2011

let-7 and miR-17-92: small-sized major players in lung cancer development.

Cancer Sci 2011 Jan;102(1):9-17

Division of Molecular Oncology, Aichi Cancer Center Research Institute, Nagoya, Japan.

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http://dx.doi.org/10.1111/j.1349-7006.2010.01707.xDOI Listing
January 2011

Novel metastasis-related gene CIM functions in the regulation of multiple cellular stress-response pathways.

Cancer Res 2010 Dec 30;70(23):9949-58. Epub 2010 Nov 30.

Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-1055DOI Listing
December 2010

Regulation of DNA polymerase POLD4 influences genomic instability in lung cancer.

Cancer Res 2010 Nov 22;70(21):8407-16. Epub 2010 Sep 22.

Division of Molecular Carcinogenesis, Nagoya University Graduate School of Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-0784DOI Listing
November 2010

Reciprocal and complementary role of MET amplification and EGFR T790M mutation in acquired resistance to kinase inhibitors in lung cancer.

Clin Cancer Res 2010 Nov 9;16(22):5489-98. Epub 2010 Nov 9.

Department of Thoracic Surgery, Aichi Cancer Center Hospital, 1-1 Kanokoden, Nagoya, Japan.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-1371DOI Listing
November 2010

Relationship of mRNA expressions of RanBP2 and topoisomerase II isoforms to cytotoxicity of amrubicin in human lung cancer cell lines.

Cancer Chemother Pharmacol 2010 Jul 7;66(2):237-43. Epub 2009 Oct 7.

Department of Thoracic Oncology, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, Nagoya, 464-8681, Japan.

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http://link.springer.com/10.1007/s00280-009-1151-1
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http://dx.doi.org/10.1007/s00280-009-1151-1DOI Listing
July 2010

Combined inhibition of MET and EGFR suppresses proliferation of malignant mesothelioma cells.

Carcinogenesis 2009 Jul 20;30(7):1097-105. Epub 2009 Apr 20.

Division of Molecular Oncology, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-ku, Nagoya, Japan.

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http://dx.doi.org/10.1093/carcin/bgp097DOI Listing
July 2009

Relationship of deregulated signaling converging onto mTOR with prognosis and classification of lung adenocarcinoma shown by two independent in silico analyses.

Cancer Res 2009 May 21;69(9):4027-35. Epub 2009 Apr 21.

Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-3403DOI Listing
May 2009

YAP1 is involved in mesothelioma development and negatively regulated by Merlin through phosphorylation.

Carcinogenesis 2008 Nov 25;29(11):2139-46. Epub 2008 Aug 25.

Division of Molecular Oncology, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-ku, Nagoya 464-8681, Japan.

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http://dx.doi.org/10.1093/carcin/bgn200DOI Listing
November 2008

Detailed characterization of a homozygously deleted region corresponding to a candidate tumor suppressor locus at 21q11-21 in human lung cancer.

Genes Chromosomes Cancer 2008 Sep;47(9):810-8

Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Japan.

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http://dx.doi.org/10.1002/gcc.20582DOI Listing
September 2008

Novel NBS1 heterozygous germ line mutation causing MRE11-binding domain loss predisposes to common types of cancer.

Cancer Res 2007 Dec;67(23):11158-65

Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya 466-8550, Japan.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-1749DOI Listing
December 2007

Lineage-specific dependency of lung adenocarcinomas on the lung development regulator TTF-1.

Cancer Res 2007 Jul;67(13):6007-11

Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-4774DOI Listing
July 2007

hDREF regulates cell proliferation and expression of ribosomal protein genes.

Mol Cell Biol 2007 Mar 12;27(6):2003-13. Epub 2007 Jan 12.

Graduate School of Life Science, University of Hyogo, Kamigori, Hyogo 678-1297, Japan.

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http://dx.doi.org/10.1128/MCB.01462-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1820502PMC
March 2007

MicroRNAs in biological processes and carcinogenesis.

Carcinogenesis 2007 Jan 6;28(1):2-12. Epub 2006 Oct 6.

Division of Molecular Oncology, Aichi Cancer Center Research Institute, Nagoya, Aichi 464-8681, Japan.

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http://dx.doi.org/10.1093/carcin/bgl185DOI Listing
January 2007

Interaction of GATA-3/T-bet transcription factors regulates expression of sialyl Lewis X homing receptors on Th1/Th2 lymphocytes.

Proc Natl Acad Sci U S A 2006 Nov 30;103(45):16894-9. Epub 2006 Oct 30.

Department of Molecular Pathology, Aichi Cancer Center, 1-1 Kanokoden, Chikusaku, Nagoya 464-8681, Japan.

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http://dx.doi.org/10.1073/pnas.0607926103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1629005PMC
November 2006

Expression profile-defined classification of lung adenocarcinoma shows close relationship with underlying major genetic changes and clinicopathologic behaviors.

J Clin Oncol 2006 Apr 20;24(11):1679-88. Epub 2006 Mar 20.

Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan.

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http://dx.doi.org/10.1200/JCO.2005.03.8224DOI Listing
April 2006

Histone modification in the TGFbetaRII gene promoter and its significance for responsiveness to HDAC inhibitor in lung cancer cell lines.

Mol Carcinog 2005 Dec;44(4):233-41

Division of Molecular Oncology, Aichi Cancer Center Research Institute, Nagoya, Japan.

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http://dx.doi.org/10.1002/mc.20135DOI Listing
December 2005

ASH1 gene is a specific therapeutic target for lung cancers with neuroendocrine features.

Cancer Res 2005 Dec;65(23):10680-5

Division of Molecular Oncology, Aichi Cancer Center Research Institute, Chikusa, Nagoya, Japan.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-1404DOI Listing
December 2005

Reduced expression of class II histone deacetylase genes is associated with poor prognosis in lung cancer patients.

Int J Cancer 2004 Oct;112(1):26-32

Division of Molecular Oncology, Aichi Cancer Center Research Institute, Nagoya, Japan.

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http://doi.wiley.com/10.1002/ijc.20395
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http://dx.doi.org/10.1002/ijc.20395DOI Listing
October 2004

Identification of decatenation G2 checkpoint impairment independently of DNA damage G2 checkpoint in human lung cancer cell lines.

Cancer Res 2004 Jul;64(14):4826-32

Division of Molecular Oncology, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chukusa-ku, Nagoya 464-8681, Japan.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-0871DOI Listing
July 2004

Decreased expression of 14-3-3sigma in neuroendocrine tumors is independent of origin and malignant potential.

Oncogene 2002 Nov;21(54):8310-9

Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Nagoya, Japan.

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http://dx.doi.org/10.1038/sj.onc.1206014DOI Listing
November 2002

Genetic alterations of multiple tumor suppressors and oncogenes in the carcinogenesis and progression of lung cancer.

Oncogene 2002 Oct;21(48):7421-34

Division of Molecular Oncology, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-ku, Nagoya 464-8681, Japan.

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http://dx.doi.org/10.1038/sj.onc.1205802DOI Listing
October 2002

Aberrant hypermethylation of the CHFR prophase checkpoint gene in human lung cancers.

Oncogene 2002 Apr;21(15):2328-33

Division of Molecular Oncology, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-ku, Nagoya 464-8681, Japan.

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http://dx.doi.org/10.1038/sj.onc.1205402DOI Listing
April 2002

Frequent and histological type-specific inactivation of 14-3-3sigma in human lung cancers.

Oncogene 2002 Apr;21(15):2418-24

Division of Molecular Oncology, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-ku, Nagoya 464-8681, Japan.

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http://dx.doi.org/10.1038/sj.onc.1205303DOI Listing
April 2002

Significant up-regulation of a novel gene, CLCP1, in a highly metastatic lung cancer subline as well as in lung cancers in vivo.

Oncogene 2002 Apr;21(18):2822-8

Division of Molecular Oncology, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-ku, Nagoya 464-8681, Japan.

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http://dx.doi.org/10.1038/sj.onc.1205405DOI Listing
April 2002

Identification of frequent G(2) checkpoint impairment and a homozygous deletion of 14-3-3epsilon at 17p13.3 in small cell lung cancers.

Cancer Res 2002 Jan;62(1):271-6

Division of Molecular Oncology, Aichi Cancer Center Research Institute, Kanokoden, Chikusa-ku, Nagoya 464-8681, Japan.

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January 2002