Publications

A Multicenter Study of Carbon-Ion Radiation Therapy for Head and Neck Adenocarcinoma.
Int J Radiat Oncol Biol Phys 2017 Oct 3;99(2):442-449. Epub 2017 May 3.
Hospital of the National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Sciences and Technology, Chiba, Japan.

Carbon-ion radiotherapy for non-small cell lung cancer with interstitial lung disease: a retrospective analysis.
Radiat Oncol 2017 Sep 2;12(1):144. Epub 2017 Sep 2.
National Institute of Radiological Sciences Hospital, National Institutes for Quantum and Radiological Sciences and Technology, 4-9-1, Anagawa, Inage-ward, Chiba, 263-8555, Japan.

Cancer-specific mortality of high-risk prostate cancer after carbon-ion radiotherapy plus long-term androgen deprivation therapy.
Cancer Sci 2017 Sep 16. Epub 2017 Sep 16.
Hospital of the National Institute of Radiological Sciences National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.

Carbon-ion re-irradiation for recurrences after initial treatment of stage I non-small cell lung cancer with carbon-ion radiotherapy.
Radiother Oncol 2017 Aug 4. Epub 2017 Aug 4.
National Institute of Radiological Sciences Hospital, National Institutes for Quantum and Radiological Sciences and Technology, Chiba-shi, Japan.

Multi-institutional retrospective study of mucoepidermoid carcinoma treated with carbon-ion radiotherapy.
Cancer Sci 2017 Jul 29;108(7):1447-1451. Epub 2017 May 29.
Hospital of the National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Sciences and Technology, Chiba, Japan.

Prognostic factors of adenoid cystic carcinoma of the head and neck in carbon-ion radiotherapy: The impact of histological subtypes.
Radiother Oncol 2017 Jun 18;123(3):387-393. Epub 2017 May 18.
Hospital of the National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Sciences and Technology, Chiba, Japan.

Progressive hypofractionated carbon-ion radiotherapy for hepatocellular carcinoma: Combined analyses of 2 prospective trials.
Cancer 2017 Jun 29. Epub 2017 Jun 29.
Hospital of the National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.

Prognostic analysis of radiation pneumonitis: carbon-ion radiotherapy in patients with locally advanced lung cancer.
Radiat Oncol 2017 May 30;12(1):91. Epub 2017 May 30.
Hospital of the National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Sciences and Technology, 4-9-1 Anagawa, Inage Ward, Chiba City, Chiba Prefecture, Japan.

Dose escalation study with respiratory-gated carbon-ion scanning radiotherapy using a simultaneous integrated boost for pancreatic cancer: simulation with four-dimensional computed tomography.
Br J Radiol 2017 Apr 9;90(1072):20160790. Epub 2017 Feb 9.
1 Hospital of the National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.

Multicenter Study of Carbon-Ion Radiation Therapy for Mucosal Melanoma of the Head and Neck: Subanalysis of the Japan Carbon-Ion Radiation Oncology Study Group (J-CROS) Study (1402 HN).
Int J Radiat Oncol Biol Phys 2017 Apr 26;97(5):1054-1060. Epub 2016 Dec 26.
Hospital of the National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Sciences and Technology, Chiba, Japan.

Normal lactate concentration range in the neonatal brain.
Magn Reson Imaging 2016 Nov 25;34(9):1269-1273. Epub 2016 Jul 25.
Department of Molecular Imaging & Theranostics, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan; Department of Radiology, Kanagawa Children's Medical Center, 2-138-4 Mutsukawa, Minami-ku, Yokohama 232-8555, Japan. Electronic address:



Impact of individual components and their combinations within a family history of hypertension on the incidence of hypertension: Toranomon hospital health management center study 22.
Medicine (Baltimore) 2016 Sep;95(38):e4564
aDepartment of Internal Medicine, Niigata University Faculty of Medicine, Niigata bHealth Management Center, Toranomon Hospital cOkinaka Memorial Institute for Medical Research, Tokyo, Japan.

Diffusion-tensor-based method for robust and practical estimation of axial and radial diffusional kurtosis.
Eur Radiol 2016 Aug 7;26(8):2559-66. Epub 2015 Oct 7.
Department of Radiology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.


Single-Fraction Carbon-Ion Radiation Therapy for Patients 80 Years of Age and Older With Stage I Non-Small Cell Lung Cancer.
Int J Radiat Oncol Biol Phys 2016 May 30;95(1):542-8. Epub 2015 Nov 30.
Research Center Hospital for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan.


Assessment of kidney dysfunction with cystatin C- and creatinine-based estimated glomerular filtration rate and predicting type 2 diabetes: Toranomon Hospital Health Management Center Study 21.
Diabetes Res Clin Pract 2016 Mar 1;113:60-8. Epub 2016 Feb 1.
Department of Internal Medicine, Niigata University Faculty of Medicine, Niigata, Japan; Health Management Center, Toranomon Hospital, Tokyo, Japan. Electronic address:

Trajectory of body mass index before the development of type 2 diabetes in Japanese men: Toranomon Hospital Health Management Center Study 15.
J Diabetes Investig 2015 May 4;6(3):289-94. Epub 2015 Jan 4.
Department of Internal Medicine, Niigata University Faculty of Medicine Niigata, Japan ; Health Management Center, Toranomon Hospital Minato-ku, Japan.

A prospective nonrandomized phase I/II study of carbon ion radiotherapy in a favorable subset of locally advanced non-small cell lung cancer (NSCLC).
Cancer 2015 Apr 13;121(8):1321-7. Epub 2015 Jan 13.
Research Center Hospital for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan; Department of Radiology, The University of Tokyo Hospital, Tokyo, Japan.

Reformulation of a clinical-dose system for carbon-ion radiotherapy treatment planning at the National Institute of Radiological Sciences, Japan.
Phys Med Biol 2015 Apr 31;60(8):3271-86. Epub 2015 Mar 31.
Medical Physics Research Group, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan.


Potential impact of joint association of alanine aminotransferase and gamma-glutamyltransferase on insulin resistance in Japan: The Toranomon Hospital Health Management Center Study 19 (TOPICS 19).
Hepatol Res 2015 Mar 21;45(3):247-58. Epub 2014 Jul 21.
Department of Health Management Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital, Tokyo, Japan; Department of Hepatology, Toranomon Hospital, Tokyo, Japan.

Transient contribution of left posterior parietal cortex to cognitive restructuring.
Sci Rep 2015 Mar 17;5:9199. Epub 2015 Mar 17.
1] Department of Cognitive Behavioral Physiology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo, Chiba 260-8670, Japan [2] Research Center for Child Mental Development, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo, Chiba 260-8670, Japan [3] Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage, Chiba 263-8555, Japan.

Simple self-reported behavioral or psychological characteristics as risk factors for future type 2 diabetes in Japanese individuals: Toranomon Hospital Health Management Center Study 14.
J Diabetes Investig 2015 Mar 16;6(2):236-41. Epub 2014 Sep 16.
Department of Internal Medicine, Niigata University Faculty of Medicine Niigata, Japan ; Health Management Center, Toranomon Hospital Tokyo, Japan.

Metabolically healthy obesity, presence or absence of fatty liver, and risk of type 2 diabetes in Japanese individuals: Toranomon Hospital Health Management Center Study 20 (TOPICS 20).
J Clin Endocrinol Metab 2014 Aug 13;99(8):2952-60. Epub 2014 May 13.
Department of Internal Medicine (Y.H., K.F., K.S., S.K., H.S.), Niigata University Faculty of Medicine, Niigata 951-8510, Japan; Health Management Center (Y.H., Y.A., H.T., K.S., S.D.H., S.K., S.H., H.S.), Okinaka Memorial Institute for Medical Research (Y.A., H.T., S.D.H., S.H.), Toranomon Hospital, Tokyo 105-8470, Japan; Ibaraki Prefectural University of Health Sciences Hospital (K.S.), Ibaraki 300-0394, Japan; and Department of Pharmacoepidemiology (S.T.), Graduate School of Medicine and Public Health, Kyoto University, Kyoto 606-8501, Japan.


Differential diagnosis of amyotrophic lateral sclerosis from Guillain-Barré syndrome by quantitative determination of TDP-43 in cerebrospinal fluid.
Int J Neurosci 2014 May 31;124(5):344-9. Epub 2013 Oct 31.
1Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science , Tokyo , Japan.

Health-related quality of life after carbon-ion radiotherapy for prostate cancer: a 3-year prospective study.
Int J Urol 2014 Apr 9;21(4):370-5. Epub 2013 Oct 9.
Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Inage, Chiba, Japan; Gunma Heavy-ion Medical Center, Gunma University, Maebashi, Gunma, Japan.

Usefulness of J-CAPRA score for high-risk prostate cancer patients treated with carbon ion radiotherapy plus androgen deprivation therapy.
Jpn J Clin Oncol 2014 Apr 28;44(4):360-5. Epub 2014 Feb 28.
*Department of Urology, Tokyo Kosei Nenkin Hospital, 5-1 Tsukudo-cho, Shinjuku-ku, Tokyo 162-8543, Japan.

Neonatal brain metabolite concentrations: an in vivo magnetic resonance spectroscopy study with a clinical MR system at 3 Tesla.
PLoS One 2013 28;8(11):e82746. Epub 2013 Nov 28.
Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan ; Department of Radiology, Kanagawa Children's Medical Center, Yokohama, Japan ; Research Center for Child Mental Development, Chiba University Graduate School of Medicine, Chiba, Japan.

Efficacy and safety in sitagliptin therapy for diabetes complicated by non-alcoholic fatty liver disease.
Hepatol Res 2013 Nov 12;43(11):1163-8. Epub 2013 Mar 12.
Department of Hepatology and Okinaka Memorial Institute for Medical Research, Toranomon Hospital, Tokyo, Japan; Department of Health Management Center, Toranomon Hospital, Tokyo, Japan.



Molecular analysis and biochemical classification of TDP-43 proteinopathy.
Brain 2012 Nov 3;135(Pt 11):3380-91. Epub 2012 Oct 3.
Department of Neuropathology and Cell Biology, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan.


Difference in malignancies of chronic liver disease due to non-alcoholic fatty liver disease or hepatitis C in Japanese elderly patients.
Hepatol Res 2012 Mar 19;42(3):264-72. Epub 2011 Dec 19.
Department of Hepatology and Okinaka Memorial Institute for Medical Research, Toranomon Hospital Department of Health Management Center, Toranomon Hospital, Tokyo Department of Third Internal Medicine (Metabolism), University of Yamanashi, Yamanashi, Japan.






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