Publications

RANKL expressed on synovial fibroblasts is primarily responsible for bone erosions during joint inflammation.
Ann Rheum Dis 2016 Jun 29;75(6):1187-95. Epub 2015 May 29.
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan Explorative Research for Advanced Technology (ERATO) Program, Japan Science and Technology Agency (JST), Takayanagi Osteonetwork Project, Tokyo, Japan.

Glucocorticoid impairs cell-cell communication by autophagy-mediated degradation of connexin 43 in osteocytes.
Oncotarget 2016 May;7(19):26966-78
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.


Inhibition of the TNF Family Cytokine RANKL Prevents Autoimmune Inflammation in the Central Nervous System.
Immunity 2015 Dec 8;43(6):1174-85. Epub 2015 Dec 8.
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan; Japan Science and Technology Agency (JST), Exploratory Research for Advanced Technology (ERATO) Program, Takayanagi Osteonetwork Project, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-0033, Japan. Electronic address:

Fezf2 Orchestrates a Thymic Program of Self-Antigen Expression for Immune Tolerance.
Cell 2015 Nov;163(4):975-87
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo 113-0033, Japan; Takayanagi Osteonetwork Project, Exploratory Research for Advanced Technology Program, Japan Science and Technology Agency (JST), Tokyo 113-0033, Japan. Electronic address:

Regulatory T cells in Arthritis.
Prog Mol Biol Transl Sci 2015 28;136:207-15. Epub 2015 Aug 28.
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan; Japan Science and Technology Agency, Exploratory Research for Advanced Technology Program, Takayanagi Osteonetwork Project, Bunkyo-ku, Tokyo, Japan. Electronic address:

Phosphoproteomic analysis of kinase-deficient mice reveals multiple TAK1 targets in osteoclast differentiation.
Biochem Biophys Res Commun 2015 Aug 20;463(4):1284-90. Epub 2015 Jun 20.
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-0033, Japan; Department of Cell Signaling, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo, 113-8510, Japan; Japan Science and Technology Agency (JST), Exploratory Research for Advanced Technology (ERATO) Program, Takayanagi Osteonetwork Project, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-0033, Japan. Electronic address:


The thymic cortical epithelium determines the TCR repertoire of IL-17-producing γδT cells.
EMBO Rep 2015 May 13;16(5):638-53. Epub 2015 Mar 13.
Department of Immunology and Pathology, Research Institute, National Center for Global Health and Medicine, Chiba, Japan

DNA methyltransferase 3a regulates osteoclast differentiation by coupling to an S-adenosylmethionine-producing metabolic pathway.
Nat Med 2015 Mar 23;21(3):281-7. Epub 2015 Feb 23.
1] Department of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences, Osaka University, Osaka, Japan. [2] WPI-Immunology Frontier Research Center, Osaka University, Osaka, Japan. [3] Japan Science and Technology Agency, CREST, Tokyo, Japan.

SnapShot: Osteoimmunology.
Cell Metab 2015 Mar;21(3):502.e1
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan and Japan Science and Technology Agency (JST), Exploratory Research for Advanced Technology (ERATO) Program, Takayanagi Osteonetwork Project, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.

Immune complexes regulate bone metabolism through FcRγ signalling.
Nat Commun 2015 Mar 31;6:6637. Epub 2015 Mar 31.
1] Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan [2] Japan Science and Technology Agency (JST), Exploratory Research for Advanced Technology (ERATO) Program, Takayanagi Osteonetwork Project, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan [3] Centre for Orthopaedic Research, School of Surgery, The University of Western Australia, 35 Stirling Highway, Crawley, Perth, Western Australia 6009, Australia.

Arthritogenic T cells in autoimmune arthritis.
Int J Biochem Cell Biol 2015 Jan 28;58:92-6. Epub 2014 Nov 28.
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan; Japan Science and Technology Agency (JST), Exploratory Research for Advanced Technology Program, Takayanagi Osteonetwork Project, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address:

Global epigenomic analysis indicates protocadherin-7 activates osteoclastogenesis by promoting cell-cell fusion.
Biochem Biophys Res Commun 2014 Dec 13;455(3-4):305-11. Epub 2014 Nov 13.
Japan Science and Technology Agency, ERATO, Takayanagi Osteonetwork Project, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address:

The immune system, bone and RANKL.
Arch Biochem Biophys 2014 Nov 12;561:118-23. Epub 2014 Jun 12.
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan; Japan Science and Technology Agency (JST), Explorative Research for Advanced Technology (ERATO) Program, Takayanagi Osteonetwork Project, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address:

Runx2-I isoform contributes to fetal bone formation even in the absence of specific N-terminal amino acids.
PLoS One 2014 22;9(9):e108294. Epub 2014 Sep 22.
Division of Mucosal Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Department of Medical Genome Science, Graduate School of Frontier Science, The University of Tokyo, Chiba, Japan; Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo, Japan.

The orally available Btk inhibitor ibrutinib (PCI-32765) protects against osteoclast-mediated bone loss.
Bone 2014 Mar 4;60:8-15. Epub 2013 Dec 4.
Department of Cell Signaling, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8549, Japan; Department of Immunology, Graduate School of Medicine, The University of Tokyo, Japan; Japan Science and Technology Agency (JST), Explorative Research for Advanced Technology (ERATO) Program, Takayanagi Osteonetwork Project, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address:

Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis.
Nat Med 2014 Jan 22;20(1):62-8. Epub 2013 Dec 22.
1] Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan. [2] Japan Science and Technology Agency (JST), Exploratory Research for Advanced Technology (ERATO) Program, Takayanagi Osteonetwork Project, Bunkyo-ku, Tokyo, Japan. [3] Centre for Orthopaedic Research, School of Surgery, The University of Western Australia, Nedlands, Western Australia, Australia.


Intracellular and extracellular ATP coordinately regulate the inverse correlation between osteoclast survival and bone resorption.
J Biol Chem 2012 Nov 17;287(45):37808-23. Epub 2012 Sep 17.
Department of Geriatric Medicine, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan.

Bone cell communication factors and Semaphorins.
Bonekey Rep 2012 Sep 19;1:183. Epub 2012 Sep 19.
Department of Cell Signaling, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University , Tokyo, Japan . ; Japan Science and Technology Agency, ERATO, Takayanagi Osteonetwork Project , Tokyo, Japan . ; Global Center of Excellence Program, International Research Center for Molecular Science in Tooth and Bone Diseases, Tokyo Medical and Dental University , Tokyo, Japan .



Stage-specific functions of leukemia/lymphoma-related factor (LRF) in the transcriptional control of osteoclast development.
Proc Natl Acad Sci U S A 2012 Feb 30;109(7):2561-6. Epub 2012 Jan 30.
Department of Cell Signaling, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8549, Japan.

MafB interacts with Gcm2 and regulates parathyroid hormone expression and parathyroid development.
J Bone Miner Res 2011 Oct;26(10):2463-72
Laboratory of Molecular and Developmental Biology, Graduate School of Biological Science, Nara Institute of Science and Technology, Ikoma, Japan.


Basic leucine zipper transcription factor, ATF-like (BATF) regulates epigenetically and energetically effector CD8 T-cell differentiation via Sirt1 expression.
Proc Natl Acad Sci U S A 2011 Sep 22;108(36):14885-9. Epub 2011 Aug 22.
Department of Cellular Physiology and Immunology, Medical Top Track Program, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.

Evidence for osteocyte regulation of bone homeostasis through RANKL expression.
Nat Med 2011 Sep 11;17(10):1231-4. Epub 2011 Sep 11.
Department of Cell Signaling, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Yushima, Bunkyo-ku, Tokyo, Japan.

Maf promotes osteoblast differentiation in mice by mediating the age-related switch in mesenchymal cell differentiation.
J Clin Invest 2010 Oct 27;120(10):3455-65. Epub 2010 Sep 27.
Department of Cell Signaling, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan.

A novel method of culturing human oral mucosal epithelial cell sheet using post-mitotic human dermal fibroblast feeder cells and modified keratinocyte culture medium for ocular surface reconstruction.
Br J Ophthalmol 2010 Sep 10;94(9):1244-50. Epub 2010 Jun 10.
Department of Ophthalmology and Visual Science, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan.


NFATc1 mediates Toll-like receptor-independent innate immune responses during Trypanosoma cruzi infection.
PLoS Pathog 2009 Jul 17;5(7):e1000514. Epub 2009 Jul 17.
Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.

Inhibitory immunoglobulin-like receptors LILRB and PIR-B negatively regulate osteoclast development.
J Immunol 2008 Oct;181(7):4742-51
Department of Experimental Immunology, Institute of Development, Aging, and Cancer, and Center of Excellence Program for Innovative Therapeutic Development Towards the Conquest of Signal Transduction Diseases, Tohoku University, Sendai, Japan.






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