Hiroshi Sakagami

Hiroshi Sakagami

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Hiroshi Sakagami

Publications by authors named "Hiroshi Sakagami"

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Synthesis, biological evaluation and in silico modelling studies of 1,3,5-trisubstituted pyrazoles carrying benzenesulfonamide as potential anticancer agents and selective cancer-associated hCA IX isoenzyme inhibitors.

Bioorg Chem 2019 Nov 28;92:103222. Epub 2019 Aug 28.

Neurofarba Department, Sezione di Scienza Farmaceutiche e Nutraceutiche, Universita degli Studi di Firenze, Via U. Schiff 6, 50019 Sesto Fiorentino (Florence), Italy.

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http://dx.doi.org/10.1016/j.bioorg.2019.103222DOI Listing
November 2019

Structures, NMR Spectroscopic Features, and Cytotoxic Properties of Oligomeric Hellinoyl (-GO--GOG)-Type Ellagitannins from the Galls of .

J Nat Prod 2019 Oct 18;82(10):2682-2695. Epub 2019 Sep 18.

Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , Okayama University , Tsushima , Okayama 700-8530 , Japan.

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http://dx.doi.org/10.1021/acs.jnatprod.9b00073DOI Listing
October 2019

New phenolic Mannich bases with piperazines and their bioactivities.

Bioorg Chem 2019 Sep 7;90:103057. Epub 2019 Jun 7.

Neurofarba Department and Laboratorio di Chimica Bioinorganica Universita' degli Studi di Firenze, Sesto Fiorentino, Italy.

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https://linkinghub.elsevier.com/retrieve/pii/S00452068193057
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http://dx.doi.org/10.1016/j.bioorg.2019.103057DOI Listing
September 2019

Synthesis and biological evaluation of some new mono Mannich bases with piperazines as possible anticancer agents and carbonic anhydrase inhibitors.

Bioorg Chem 2019 Sep 28;90:103095. Epub 2019 Jun 28.

Neurofarba Department, Sezione di Scienza Farmaceutiche e Nutraceutiche, Universita egli Studi di Firenze, Via U. Schiff 6, 50019 Sesto Fiorentino (Florence), Italy.

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https://linkinghub.elsevier.com/retrieve/pii/S00452068193000
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http://dx.doi.org/10.1016/j.bioorg.2019.103095DOI Listing
September 2019

Steroidal constituents isolated from the seeds of .

Nat Prod Res 2019 Sep 20:1-6. Epub 2019 Sep 20.

Department of Medicinal Pharmacognosy, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences , Tokyo , Japan.

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http://dx.doi.org/10.1080/14786419.2019.1667351DOI Listing
September 2019

Synthesis and Cytotoxicities of New Azafluorenones with Apoptotic Mechanism of Action and Cell Cycle Analysis.

Anticancer Agents Med Chem 2018 ;18(12):1770-1778

Department of Chemistry, Faculty of Science, Ataturk University, Erzurum 25240, Turkey.

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http://dx.doi.org/10.2174/1871520618666180525085445DOI Listing
July 2019

Quantitative Structure-Cytotoxicity Relationship of Azulene Amide Derivatives.

Anticancer Res 2019 Jul;39(7):3507-3518

Meikai University Research Institute of Odontology (M-RIO), Meikai University School of Dentistry, Sakado, Japan.

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http://dx.doi.org/10.21873/anticanres.13497DOI Listing
July 2019

Induction of Non-Apoptotic Cell Death by Adrenergic Agonists in Human Oral Squamous Cell Carcinoma Cell Lines.

Anticancer Res 2019 Jul;39(7):3519-3529

Department of Anesthesiology, Saitama Medical University, Faculty of Medicine, Moroyama, Japan.

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http://dx.doi.org/10.21873/anticanres.13498DOI Listing
July 2019

Establishment of a Primary Culture System of Human Periodontal Ligament Cells that Differentiate into Cementum Protein 1-expressing Cementoblast-like Cells.

In Vivo 2019 Mar-Apr;33(2):349-352

Division of Endodontics and Operative Dentistry, Department of Restorative and Biomaterial Sciences, Meikai University School of Dentistry, Saitama, Japan.

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http://dx.doi.org/10.21873/invivo.11480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506315PMC
June 2019

QSAR Prediction Model to Search for Compounds with Selective Cytotoxicity Against Oral Cell Cancer.

Medicines (Basel) 2019 Apr 1;6(2). Epub 2019 Apr 1.

Department of Medical Molecular Informatics, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan.

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https://www.mdpi.com/2305-6320/6/2/45
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http://dx.doi.org/10.3390/medicines6020045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631777PMC
April 2019

Introduction to the Special Issue "Biological Efficacy of Natural and Chemically Modified Products against Oral Inflammatory Lesions".

Authors:
Hiroshi Sakagami

Medicines (Basel) 2019 Apr 28;6(2). Epub 2019 Apr 28.

Meikai University Research Institute of Odontology (M-RIO), 1-1 Keyakidai, Sakado, Saitama 350-0283, Japan.

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http://dx.doi.org/10.3390/medicines6020052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630427PMC
April 2019

Synthesis and bioactivities of pyrazoline benzensulfonamides as carbonic anhydrase and acetylcholinesterase inhibitors with low cytotoxicity.

Bioorg Chem 2019 03 20;84:511-517. Epub 2018 Dec 20.

Neurofarba Department e Laboratorio di Chimica Bioinorganica, Universita Degli Studi di Firenze, Sesto Fiorentino (Florence), Italy.

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https://linkinghub.elsevier.com/retrieve/pii/S00452068183132
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http://dx.doi.org/10.1016/j.bioorg.2018.12.028DOI Listing
March 2019

Kampo Therapies and the Use of Herbal Medicines in the Dentistry in Japan.

Medicines (Basel) 2019 Feb 28;6(1). Epub 2019 Feb 28.

Division of Microbiology, Department of Oral Science, Kanagawa Dental University, 82 Inaoka-cho, Yokosuka 238-8580, Japan.

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http://dx.doi.org/10.3390/medicines6010034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473445PMC
February 2019

Change in Amino Acid Pools During Neuronal Differentiation of PC12 Cells.

In Vivo 2018 Nov-Dec;32(6):1403-1408

Meikai University Research Institute of Odontology (M-RIO), Meikai University School of Dentistry, Saitama, Japan

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http://iv.iiarjournals.org/lookup/doi/10.21873/invivo.11392
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http://dx.doi.org/10.21873/invivo.11392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365737PMC
January 2019

Search for Drugs Used in Hospitals to Treat Stomatitis.

Medicines (Basel) 2019 Jan 29;6(1). Epub 2019 Jan 29.

Meikai University Research Institute of Odontology (M-RIO), 1-1 Keyakidai, Sakado, Saitama 350-0283, Japan.

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http://dx.doi.org/10.3390/medicines6010019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473359PMC
January 2019

New azafluorenones with cytotoxic and carbonic anhydrase inhibitory properties: 2-Aryl-4-(4-hydroxyphenyl)-5H-indeno[1,2-b]pyridin-5-ones.

Bioorg Chem 2018 12 8;81:433-439. Epub 2018 Sep 8.

Neurofarba Department, Sezione di Scienza Farmaceutiche e Nutraceutiche, Universita egli Studi di Firenze, Via U. Schiff 6, 50019 Sesto Fiorentino (Florence), Italy.

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http://dx.doi.org/10.1016/j.bioorg.2018.09.013DOI Listing
December 2018

Recent Progress of Basic Studies of Natural Products and Their Dental Application.

Medicines (Basel) 2018 Dec 25;6(1). Epub 2018 Dec 25.

Department of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, Sakado, Saitama 350-0295, Japan.

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http://www.mdpi.com/2305-6320/6/1/4
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http://dx.doi.org/10.3390/medicines6010004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473826PMC
December 2018

Photodynamic Therapy with Pyoktanin Blue and Diode Laser for Elimination of .

In Vivo 2018 Jul-Aug;32(4):707-712

Division of Endodontics and Operative Dentistry, Department of Restorative and Biomaterials Sciences, School of Dentistry, Meikai University, Saitama, Japan.

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http://dx.doi.org/10.21873/invivo.11298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117781PMC
October 2018

Antitumor Activity of Alkylaminoguaiazulenes.

In Vivo 2018 May-Jun;32(3):541-547

Meikai University Research Institute of Odontology (M-RIO), Saitama, Japan

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http://dx.doi.org/10.21873/invivo.11273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000785PMC
September 2018

Quantitative Structure-Cytotoxicity Relationship of Pyrano[4,3-]chromones.

Anticancer Res 2018 Aug;38(8):4449-4457

Department of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, Saitama, Japan.

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http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.12
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http://dx.doi.org/10.21873/anticanres.12747DOI Listing
August 2018

Quantitative Structure-Cytotoxicity Relationship of 3-(-Cyclicamino)chromone Derivatives.

Anticancer Res 2018 Aug;38(8):4459-4467

Department of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, Saitama, Japan.

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http://dx.doi.org/10.21873/anticanres.12748DOI Listing
August 2018

Quantitative Structure-Cytotoxicity Relationship of 2-(-cyclicamino)chromone Derivatives.

Anticancer Res 2018 Jul;38(7):3897-3906

Department of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, Saitama, Japan.

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http://dx.doi.org/10.21873/anticanres.12674DOI Listing
July 2018

Aestivalosides A-L, twelve pregnane glycosides from the seeds of Adonis aestivalis.

Phytochemistry 2018 Jun 19;150:75-84. Epub 2018 Mar 19.

School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1, Horinouchi, Hachioji, Tokyo 192-0392, Japan.

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http://dx.doi.org/10.1016/j.phytochem.2018.03.001DOI Listing
June 2018

Quantitative Structure-Cytotoxicity Relationship of Furo[2,3-]chromones.

Anticancer Res 2018 Jun;38(6):3283-3290

Department of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, Saitama, Japan.

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http://dx.doi.org/10.21873/anticanres.12593DOI Listing
June 2018

New anticancer drug candidates sulfonamides as selective hCA IX or hCA XII inhibitors.

Bioorg Chem 2018 04 16;77:411-419. Epub 2018 Jan 16.

Neurofarba Department, Sezione di Scienza Farmaceutiche e Nutraceutiche, Universita degli Studi di Firenze, Via U. Schiff 6, 50019 Sesto Fiorentino (Florence), Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2018.01.021DOI Listing
April 2018

Quantitative Structure-Cytotoxicity Relationship of 2-Azolylchromones.

Anticancer Res 2018 02;38(2):763-770

Department of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, Sakado, Japan.

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http://dx.doi.org/10.21873/anticanres.12282DOI Listing
February 2018

Quantitative Structure-Cytotoxicity Relationship of Cinnamic Acid Phenetyl Esters.

Anticancer Res 2018 02;38(2):817-823

Department of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, Sakado, Japan.

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http://dx.doi.org/10.21873/anticanres.12289DOI Listing
February 2018

Dental Application of Natural Products.

Medicines (Basel) 2018 Feb 14;5(1). Epub 2018 Feb 14.

Meikai University Research Institute of Odontology (M-RIO), 1-1 Keyakidai, Sakado, Saitama 350-0283, Japan.

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http://dx.doi.org/10.3390/medicines5010021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874586PMC
February 2018

Combined SN-38 and gefitinib treatment promotes CD44 degradation in head and neck squamous cell carcinoma cells.

Oncol Rep 2018 Jan 21;39(1):367-375. Epub 2017 Nov 21.

Division of Oral and Maxillofacial Surgery, Department of Diagnostic and Therapeutic Sciences, Meikai University, Sakado, Saitama 350-0283, Japan.

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http://www.spandidos-publications.com/10.3892/or.2017.6105
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http://dx.doi.org/10.3892/or.2017.6105DOI Listing
January 2018

Three new flavonoids, proanthocyanidin, and accompanying phenolic constituents from Feijoa sellowiana.

Biosci Biotechnol Biochem 2018 Jan 3;82(1):31-41. Epub 2018 Jan 3.

a Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , Okayama University , Okayama , Japan.

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http://dx.doi.org/10.1080/09168451.2017.1412246DOI Listing
January 2018

Designing, synthesis and bioactivities of 4-[3-(4-hydroxyphenyl)-5-aryl-4,5-dihydro-pyrazol-1-yl]benzenesulfonamides.

J Enzyme Inhib Med Chem 2017 Dec 23;32(1):169-175. Epub 2016 Oct 23.

d Polo Scientifico , Laboratorio di Chimica Bioinorganica, Universita degli Studi di Firenze , Sesto Fiorentino , Italy.

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http://dx.doi.org/10.1080/14756366.2016.1243536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009964PMC
December 2017

Microwave-assisted synthesis and bioevaluation of new sulfonamides.

J Enzyme Inhib Med Chem 2017 Dec;32(1):369-374

f Neurofarba Departmente Laboratorio di Chimica Bioinorganica , Universita degli Studi di Firenze , Sesto Fiorentino , Florence , Italy.

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http://dx.doi.org/10.1080/14756366.2016.1254207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009867PMC
December 2017

Search for New Type of Anticancer Drugs with High Tumor Specificity and Less Keratinocyte Toxicity.

Anticancer Res 2017 11;37(11):5919-5924

Meikai University Research Institute of Odontology (M-RIO), Sakado, Japan

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http://dx.doi.org/10.21873/anticanres.12038DOI Listing
November 2017

Quantitative Structure-Cytotoxicity Relationship of Newly Synthesized Piperic Acid Esters.

Anticancer Res 2017 11;37(11):6161-6168

Department of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, Saitama, Japan.

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http://dx.doi.org/10.21873/anticanres.12065DOI Listing
November 2017

Quantitative Structure-Cytotoxicity Relationship of Aurones.

Anticancer Res 2017 11;37(11):6169-6176

Department of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, Saitama, Japan.

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http://dx.doi.org/10.21873/anticanres.12066DOI Listing
November 2017

Steroidal Glycosides from Convallaria majalis Whole Plants and Their Cytotoxic Activity.

Int J Mol Sci 2017 Nov 7;18(11). Epub 2017 Nov 7.

School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.

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http://dx.doi.org/10.3390/ijms18112358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713327PMC
November 2017

Orthodontic treatment-induced temporal alteration of jaw-opening reflex excitability.

J Neurophysiol 2017 10 19;118(4):2289-2295. Epub 2017 Jul 19.

Division of Orthodontics, Department of Human Development and Fostering, Meikai University School of Dentistry, Sakado, Saitama, Japan.

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http://dx.doi.org/10.1152/jn.00379.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629273PMC
October 2017

6-Benzylidene-2-[4-(pyridin-3-ylcarboxy)benzylidene]cyclohexanones: A novel cluster of tumour-selective cytotoxins.

Bioorg Med Chem Lett 2017 04 10;27(7):1611-1615. Epub 2017 Feb 10.

Drug Discovery and Development Research Group, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5E5, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2017.02.016DOI Listing
April 2017

A Novel Methodology for Synthesis of 1,5,6-Trisubstituted 2(1H)-Pyrazinones of Biological Interest.

Chem Pharm Bull (Tokyo) 2017 ;65(4):365-372

Faculty of Pharmaceutical Sciences, Matsuyama University.

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http://dx.doi.org/10.1248/cpb.c16-00830DOI Listing
April 2017

Anti-inflammatory Activity of Hangeshashinto in IL-1β-stimulated Gingival and Periodontal Ligament Fibroblasts.

In Vivo 2016 May-Jun;30(3):257-63

Division of Pharmacology, Meikai University School of Dentistry, Sakado, Japan Division of MPL, Meikai University School of Dentistry, Sakado, Japan

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March 2017

Induction of Apoptosis in Human Oral Keratinocyte by Doxorubicin.

Anticancer Res 2017 03;37(3):1023-1029

Daiwa Biological Research Institute Co, Ltd., Kanagawa, Japan.

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http://dx.doi.org/10.21873/anticanres.11412DOI Listing
March 2017

Synthesis and bioactivity studies of 1-aryl-3-(2-hydroxyethylthio)-1-propanones.

J Enzyme Inhib Med Chem 2016 19;31(sup3):105-109. Epub 2016 Jul 19.

d Neurofarba Department and Laboratorio Di Chimica Bioinorganica, Università Degli Studi Di Firenze , Sesto Fiorentino (Florence) , Italy , and.

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http://dx.doi.org/10.1080/14756366.2016.1209495DOI Listing
February 2017

Synthesis, cytotoxicity and carbonic anhydrase inhibitory activities of new pyrazolines.

J Enzyme Inhib Med Chem 2016 31;31(sup4):20-24. Epub 2016 Aug 31.

a Department of Pharmaceutical Chemistry , Faculty of Pharmacy, Ataturk University , Erzurum , Turkey.

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http://dx.doi.org/10.1080/14756366.2016.1217852DOI Listing
February 2017

Synthesis and bioactivities of halogen bearing phenolic chalcones and their corresponding bis Mannich bases.

J Enzyme Inhib Med Chem 2016 4;31(sup4):125-131. Epub 2016 Sep 4.

c Neurofarba Department and Laboratorio di Chimica Bioinorganica, Università degli Studi di Firenze , Florence , Italy.

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http://dx.doi.org/10.1080/14756366.2016.1221825DOI Listing
February 2017

Gene Expression Analysis of Cultured Rat-Endothelial Cells after Nd:YAG Laser Irradiation by Affymetrix GeneChip Array.

In Vivo 2017 01;31(1):51-54

Meikai Pharmaco-Medical Laboratory (MPL), Meikai University School of Dentistry, Saitama, Japan.

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http://dx.doi.org/10.21873/invivo.11024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354147PMC
January 2017

Carbonic anhydrase inhibition and cytotoxicity studies of Mannich base derivatives of thymol.

J Enzyme Inhib Med Chem 2016 Dec 5;31(6):1375-80. Epub 2016 Feb 5.

b Polo Scientifico, Laboratorio di Chimica Bioinorganica, Universita degli Studi di Firenze , Sesto Fiorentino , Italy , and.

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http://dx.doi.org/10.3109/14756366.2016.1140755DOI Listing
December 2016

Quest for Cells Responsible for Age-related Increase of Salivary Glycine and Proline.

In Vivo 2016 Mar-Apr;30(2):91-7

Meikai University School of Dentistry, Sakado, Saitama, Japan

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December 2016

Morphine and Fentanyl Citrate Induce Retrotransposition of Long Interspersed Element-1.

In Vivo 2016 Mar-Apr;30(2):113-8

Division of Pharmacology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, Saitama, Japan.

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December 2016

Synthesis and bioactivity studies on new 4-(3-(4-Substitutedphenyl)-3a,4-dihydro-3H-indeno[1,2-c]pyrazol-2-yl) benzenesulfonamides.

J Enzyme Inhib Med Chem 2016 Dec 30;31(6):1619-24. Epub 2016 Mar 30.

e Neurofarba Department and Laboratorio di Chimica Bioinorganica , Università degli Studi di Firenze , Sesto Fiorentino , Italy.

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http://dx.doi.org/10.3109/14756366.2016.1160077DOI Listing
December 2016

Niacin esters of chalcones with tumor-selective properties.

J Enzyme Inhib Med Chem 2016 Dec 2;31(6):1451-6. Epub 2016 Jun 2.

a Drug Discovery and Development Research Group, College of Pharmacy and Nutrition, University of Saskatchewan , Saskatoon , Canada .

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http://dx.doi.org/10.3109/14756366.2016.1144595DOI Listing
December 2016

Quantitative Structure-cytotoxicity Relationship of 3-Benzylidenechromanones.

Anticancer Res 2016 11;36(11):5803-5812

Faculty of Pharmaceutical Sciences, Josai University, Sakado, Japan.

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http://dx.doi.org/10.21873/anticanres.11164DOI Listing
November 2016

Cytotoxic Components Against Human Oral Squamous Cell Carcinoma Isolated from Andrographis paniculata.

Anticancer Res 2016 11;36(11):5931-5935

Faculty of Pharmaceutical Sciences, Josai University, Sakado, Japan

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http://dx.doi.org/10.21873/anticanres.11180DOI Listing
November 2016

Synthesis of some acrylophenones with N-methylpiperazine and evaluation of their cytotoxicities.

J Enzyme Inhib Med Chem 2016 20;31(1):147-51. Epub 2015 Feb 20.

b Division of Pharmacology , Meikai University School of Dentistry , Sakado , Saitama , Japan.

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http://dx.doi.org/10.3109/14756366.2015.1014474DOI Listing
October 2016

Synthesis of mono Mannich bases of 2-(4-hydroxybenzylidene)-2,3-dihydroinden-1-one and evaluation of their cytotoxicities.

J Enzyme Inhib Med Chem 2016 Oct 6;31(5):818-23. Epub 2015 Aug 6.

a Department of Pharmaceutical Chemistry, Faculty of Pharmacy , Ataturk University , Erzurum , Turkey and.

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http://dx.doi.org/10.3109/14756366.2015.1070263DOI Listing
October 2016

Hyaluronan induces odontoblastic differentiation of dental pulp stem cells via CD44.

Stem Cell Res Ther 2016 09 20;7(1):135. Epub 2016 Sep 20.

Division of Pharmacology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, 1-1 Keyakidai, Sakado, Saitama, 350-0283, Japan.

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http://dx.doi.org/10.1186/s13287-016-0399-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029108PMC
September 2016

Tumour-specific cytotoxicity and structure-activity relationships of novel 1-[3-(2-methoxyethylthio)propionyl]-3,5-bis(benzylidene)-4-piperidones.

Bioorg Med Chem 2016 05 30;24(10):2206-14. Epub 2016 Mar 30.

Drug Discovery and Development Research Group, College of Pharmacy and Nutrition, University of Saskatchewan, 110 Science Place, Saskatoon, Saskatchewan S7N 5C9, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2016.03.056DOI Listing
May 2016

Rhinacanthin C Inhibits Osteoclast Differentiation and Bone Resorption: Roles of TRAF6/TAK1/MAPKs/NF-κB/NFATc1 Signaling.

PLoS One 2015 17;10(6):e0130174. Epub 2015 Jun 17.

Division of Biochemistry, Department of Oral Biology and Tissue Engineering, Meikai University School of Dentistry, Sakado, Saitama, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0130174PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471279PMC
April 2016

Hydrolyzable Tannins of Tamaricaceous Plants. 7.1 Structures and Cytotoxic Properties of Oligomeric Ellagitannins from Leaves of Tamarix nilotica and Cultured Tissues of Tamarix tetrandra.

J Nat Prod 2016 Apr 3;79(4):984-95. Epub 2016 Mar 3.

Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University , Tsushima, Okayama 700-8530, Japan.

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http://dx.doi.org/10.1021/acs.jnatprod.5b01065DOI Listing
April 2016

3,5-Bis(3-alkylaminomethyl-4-hydroxybenzylidene)-4-piperidones: A Novel Class of Potent Tumor-Selective Cytotoxins.

J Med Chem 2016 Jan 7;59(2):763-9. Epub 2016 Jan 7.

Drug Discovery and Development Research Group, College of Pharmacy and Nutrition, University of Saskatchewan , Saskatoon, Saskatchewan S7H 5C9, Canada.

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http://dx.doi.org/10.1021/acs.jmedchem.5b01706DOI Listing
January 2016

Quantitative Structure-Cytotoxicity Relationship of 3-Styryl-2H-chromenes.

Anticancer Res 2015 Oct;35(10):5299-307

Faculty of Pharmaceutical Sciences, Josai University, Sakado, Saitama, Japan.

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October 2015

Quantitative Structure-Cytotoxicity Relationship of Oleoylamides.

Anticancer Res 2015 Oct;35(10):5341-51

Laboratory of Bioorganic Chemistry, Department of Pharmaceutical and Health Sciences, Faculty of Pharmaceutical Sciences, Josai University, Sakado, Japan.

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October 2015

A rare type of sesquiterpene and β-santalol derivatives from Santalum album and their cytotoxic activities.

Chem Pharm Bull (Tokyo) 2014 ;62(12):1192-9

Tokyo University of Pharmacy and Life Sciences, School of Pharmacy.

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http://dx.doi.org/10.1248/cpb.c14-00457DOI Listing
July 2015

Alteration of metabolomic profiles by titanium dioxide nanoparticles in human gingivitis model.

Biomaterials 2015 Jul 22;57:33-40. Epub 2015 Apr 22.

Division of Pharmacology, Meikai University School of Dentistry, Sakado, Saitama 350-0283, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2015.03.059DOI Listing
July 2015

Synthesis and biological evaluation of 1,5-bis(4-hydroxy-3-methoxyphenyl)penta-1,4-dien-3-one and its aminomethyl derivatives.

J Enzyme Inhib Med Chem 2015 Jun 28;30(3):383-8. Epub 2014 Jul 28.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ataturk University , Erzurum , Turkey and.

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http://dx.doi.org/10.3109/14756366.2014.940934DOI Listing
June 2015

Effects of TiO2 nano glass ionomer cements against normal and cancer oral cells.

In Vivo 2014 Sep-Oct;28(5):895-907

Division of Pharmacology, Meikai University School of Dentistry, Sakado, Saitama, Japan

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May 2015

Biological activities and possible dental application of three major groups of polyphenols.

Authors:
Hiroshi Sakagami

J Pharmacol Sci 2014 27;126(2):92-106. Epub 2014 Sep 27.

Division of Pharmacology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, Japan.

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http://dx.doi.org/10.1254/jphs.14r04crDOI Listing
May 2015

Cytotoxicity and pro-inflammatory action of chemo-mechanical caries-removal agents against oral cells.

In Vivo 2014 Jul-Aug;28(4):549-56

Division of Pharmacology, Meikai University School of Dentistry, Sakado, Saitama, Japan

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February 2015

Anti-inflammatory potential of Rikkosan based on IL-1β network through macrophages to oral tissue cells.

In Vivo 2014 Jul-Aug;28(4):563-9

Division of Pharmacology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, Sakado, Saitama, Japan

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February 2015

Anti-UV activity of Kampo medicines and constituent plant extracts: re-evaluation with skin keratinocyte system.

In Vivo 2014 Jul-Aug;28(4):571-8

Division of Pharmacology, Department of Diagnostic and Therapeutic Sciences, Saitama, Japan

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February 2015

Karataviosides G-K, five new bisdesmosidic steroidal glycosides from the bulbs of Allium karataviense.

Steroids 2015 Jan 21;93:96-104. Epub 2014 Nov 21.

Department of Medicinal Pharmacognosy, Tokyo University of Pharmacy and Life Sciences, School of Pharmacy, 1432-1, Horinouchi, Hachioji, Tokyo 192-0392, Japan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0039128X140027
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http://dx.doi.org/10.1016/j.steroids.2014.09.010DOI Listing
January 2015

Effects of TiO2 nanoparticles on cytotoxic action of chemotherapeutic drugs against a human oral squamous cell carcinoma cell line.

In Vivo 2014 Mar-Apr;28(2):209-15

Division of Pharmacology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, Sakado, Saitama 350-0283, Japan.

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November 2014

Induction of prostaglandin E2 production by TiO2 nanoparticles in human gingival fibroblast.

In Vivo 2014 Mar-Apr;28(2):217-22

Division of Pharmacology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, Sakado, Saitama 350-0283, Japan.

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November 2014

Quantitative structure-cytotoxicity relationship of 3-styrylchromones.

Anticancer Res 2014 Oct;34(10):5405-11

Division of Pharmacology, Meikai University School of Dentistry, Sakado, Saitama, Japan

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October 2014

Quantitative structure-cytotoxicity relationship of piperic acid amides.

Anticancer Res 2014 Sep;34(9):4877-84

Division of Pharmacology, Meikai University School of Dentistry, Sakado, Saitama, Japan

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September 2014

Search of new cytotoxic crude materials against human oral squamous cell carcinoma using 1H NMR-based metabolomics.

Anticancer Res 2014 Aug;34(8):4117-20

Faculty of Pharmaceutical Sciences, Josai University, Saitama, Japan

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August 2014

Quantitative structure-cytotoxicity relationship of phenylpropanoid amides.

Anticancer Res 2014 Jul;34(7):3543-8

Division of Pharmacology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, Sakado, Saitama, Japan

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July 2014