Hiroshi Nokihara

Hiroshi Nokihara

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Hiroshi Nokihara

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Perspectives of non-specialists on the potential to serve as ethics committee members.

J Int Med Res 2019 May 24;47(5):1868-1876. Epub 2019 Jan 24.

1 Clinical Trial Center for Developmental Therapeutics, Tokushima University Hospital, Tokushima, Japan.

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http://dx.doi.org/10.1177/0300060518823941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567771PMC
May 2019

Paclitaxel for relapsed small-cell lung cancer patients with idiopathic interstitial pneumonias.

Mol Clin Oncol 2019 May 19;10(5):541-546. Epub 2019 Mar 19.

Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Tokushima 770-8503, Japan.

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http://dx.doi.org/10.3892/mco.2019.1828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449879PMC
May 2019

The clinical features of older patients with lung cancer in comparison with their younger counterparts.

Respir Investig 2019 Jan 15;57(1):40-48. Epub 2018 Nov 15.

Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15, Kuramoto-cho, Tokushima 770-8503, Japan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22125345183011
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http://dx.doi.org/10.1016/j.resinv.2018.10.003DOI Listing
January 2019

Present Status and Perspectives on Future Roles of Japanese Clinical Research Coordinators.

J Clin Med Res 2018 Dec 30;10(12):877-882. Epub 2018 Oct 30.

Integrated Center for Advanced Medical Technologies, Kochi Medical School Hospital, Kochi, Japan.

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http://dx.doi.org/10.14740/jocmr3602wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225862PMC
December 2018

A multicenter, open-label, phase II trial of S-1 plus carboplatin in advanced non-small cell lung cancer patients with interstitial lung disease.

Lung Cancer 2018 11 12;125:93-99. Epub 2018 Sep 12.

Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01695002183056
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http://dx.doi.org/10.1016/j.lungcan.2018.09.007DOI Listing
November 2018

Research ethics consultation: an attempt and 5-year experience in a Japanese University Hospital.

BMC Res Notes 2018 Sep 12;11(1):665. Epub 2018 Sep 12.

Clinical Trial Center for Developmental Therapeutics, Tokushima University Hospital, Kuramoto-cho 2, Tokushima, 770-8503, Japan.

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http://dx.doi.org/10.1186/s13104-018-3772-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134693PMC
September 2018

PD-L1 expression in neuroendocrine tumors of the lung.

Lung Cancer 2017 06 24;108:115-120. Epub 2017 Mar 24.

Department of Thoracic Oncology, National Cancer Center Hospital, Tsukiji 5-1-1, Chuo-ku, Tokyo 104-0045, Japan.

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http://dx.doi.org/10.1016/j.lungcan.2017.03.006DOI Listing
June 2017

Phase I study of Nivolumab, an anti-PD-1 antibody, in patients with malignant solid tumors.

Invest New Drugs 2017 04 8;35(2):207-216. Epub 2016 Dec 8.

Department of Thoracic Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji Chuo-ku, Tokyo, 104-0045, Japan.

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http://dx.doi.org/10.1007/s10637-016-0411-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352798PMC
April 2017

Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations.

Authors:
Wei Jie Seow Keitaro Matsuo Chao Agnes Hsiung Kouya Shiraishi Minsun Song Hee Nam Kim Maria Pik Wong Yun-Chul Hong H Dean Hosgood Zhaoming Wang I-Shou Chang Jiu-Cun Wang Nilanjan Chatterjee Margaret Tucker Hu Wei Tetsuya Mitsudomi Wei Zheng Jin Hee Kim Baosen Zhou Neil E Caporaso Demetrius Albanes Min-Ho Shin Lap Ping Chung She-Juan An Ping Wang Hong Zheng Yasushi Yatabe Xu-Chao Zhang Young Tae Kim Xiao-Ou Shu Young-Chul Kim Bryan A Bassig Jiang Chang James Chung Man Ho Bu-Tian Ji Michiaki Kubo Yataro Daigo Hidemi Ito Yukihide Momozawa Kyota Ashikawa Yoichiro Kamatani Takayuki Honda Hiromi Sakamoto Hideo Kunitoh Koji Tsuta Shun-Ichi Watanabe Hiroshi Nokihara Yohei Miyagi Haruhiko Nakayama Shingo Matsumoto Masahiro Tsuboi Koichi Goto Zhihua Yin Jianxin Shi Atsushi Takahashi Akiteru Goto Yoshihiro Minamiya Kimihiro Shimizu Kazumi Tanaka Tangchun Wu Fusheng Wei Jason Y Y Wong Fumihiko Matsuda Jian Su Yeul Hong Kim In-Jae Oh Fengju Song Victor Ho Fun Lee Wu-Chou Su Yuh-Min Chen Gee-Chen Chang Kuan-Yu Chen Ming-Shyan Huang Pan-Chyr Yang Hsien-Chih Lin Yong-Bing Xiang Adeline Seow Jae Yong Park Sun-Seog Kweon Chien-Jen Chen Haixin Li Yu-Tang Gao Chen Wu Biyun Qian Daru Lu Jianjun Liu Hyo-Sung Jeon Chin-Fu Hsiao Jae Sook Sung Ying-Huang Tsai Yoo Jin Jung Huan Guo Zhibin Hu Wen-Chang Wang Charles C Chung Charles Lawrence Laurie Burdett Meredith Yeager Kevin B Jacobs Amy Hutchinson Sonja I Berndt Xingzhou He Wei Wu Junwen Wang Yuqing Li Jin Eun Choi Kyong Hwa Park Sook Whan Sung Li Liu Chang Hyun Kang Lingmin Hu Chung-Hsing Chen Tsung-Ying Yang Jun Xu Peng Guan Wen Tan Chih-Liang Wang Alan Dart Loon Sihoe Ying Chen Yi Young Choi Jen-Yu Hung Jun Suk Kim Ho-Il Yoon Qiuyin Cai Chien-Chung Lin In Kyu Park Ping Xu Jing Dong Christopher Kim Qincheng He Reury-Perng Perng Chih-Yi Chen Roel Vermeulen Junjie Wu Wei-Yen Lim Kun-Chieh Chen John K C Chan Minjie Chu Yao-Jen Li Jihua Li Hongyan Chen Chong-Jen Yu Li Jin Yen-Li Lo Ying-Hsiang Chen Joseph F Fraumeni Jie Liu Taiki Yamaji Yang Yang Belynda Hicks Kathleen Wyatt Shengchao A Li Juncheng Dai Hongxia Ma Guangfu Jin Bao Song Zhehai Wang Sensen Cheng Xuelian Li Yangwu Ren Ping Cui Motoki Iwasaki Taichi Shimazu Shoichiro Tsugane Junjie Zhu Gening Jiang Ke Fei Guoping Wu Li-Hsin Chien Hui-Ling Chen Yu-Chun Su Fang-Yu Tsai Yi-Song Chen Jinming Yu Victoria L Stevens Ite A Laird-Offringa Crystal N Marconett Dongxin Lin Kexin Chen Yi-Long Wu Maria Teresa Landi Hongbing Shen Nathaniel Rothman Takashi Kohno Stephen J Chanock Qing Lan

Hum Mol Genet 2017 01;26(2):454-465

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.

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http://dx.doi.org/10.1093/hmg/ddw414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856088PMC
January 2017

Phase I study of the second-generation, recombinant, human EGFR antibody necitumumab in Japanese patients with advanced solid tumors.

Cancer Chemother Pharmacol 2016 Nov 15;78(5):995-1002. Epub 2016 Sep 15.

Department of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan.

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http://dx.doi.org/10.1007/s00280-016-3154-zDOI Listing
November 2016

Simultaneous optimization of limited sampling points for pharmacokinetic analysis of amrubicin and amrubicinol in cancer patients.

Asia Pac J Clin Oncol 2016 Sep 7;12(3):259-64. Epub 2016 Mar 7.

Department of Pharmacy, National Cancer Center Hospital, Tokyo, Japan.

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http://dx.doi.org/10.1111/ajco.12485DOI Listing
September 2016

Phase I trial of volasertib, a Polo-like kinase inhibitor, in Japanese patients with advanced solid tumors.

Invest New Drugs 2016 Feb 2;34(1):66-74. Epub 2015 Dec 2.

Department of Thoracic Oncology, National Cancer Centre Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

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http://dx.doi.org/10.1007/s10637-015-0300-0DOI Listing
February 2016

Candidates for Intensive Local Treatment in cIIIA-N2 Non-Small Cell Lung Cancer: Deciphering the Heterogeneity.

Int J Radiat Oncol Biol Phys 2016 Jan 26;94(1):155-162. Epub 2015 Sep 26.

Department of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan; Advanced Clinical Research of Cancer, Juntendo University Graduate School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.ijrobp.2015.09.026DOI Listing
January 2016

Phase 1 study of galunisertib, a TGF-beta receptor I kinase inhibitor, in Japanese patients with advanced solid tumors.

Cancer Chemother Pharmacol 2015 Dec 3;76(6):1143-52. Epub 2015 Nov 3.

Department of Thoracic Oncology, National Cancer Center Hospital, Tsukiji 5-1-1, Chuo-ku, Tokyo, 104-0045, Japan.

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http://link.springer.com/10.1007/s00280-015-2895-4
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http://dx.doi.org/10.1007/s00280-015-2895-4DOI Listing
December 2015

Phase II study of amrubicin at a dose of 45 mg/m2 in patients with previously treated small-cell lung cancer.

Jpn J Clin Oncol 2015 Oct 31;45(10):941-6. Epub 2015 Jul 31.

Department of Thoracic Oncology, National Cancer Center Hospital, Tokyo.

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http://dx.doi.org/10.1093/jjco/hyv107DOI Listing
October 2015

Phase I study of the anti-MET antibody onartuzumab in patients with solid tumors and MET-positive lung cancer.

Invest New Drugs 2015 Jun 18;33(3):632-40. Epub 2015 Mar 18.

Department of Thoracic Medical Oncology, Cancer Institute Hospital of Japanese Foundation for Cancer Research, 3-10-6 Ariake, Koto-ku, Tokyo, 135-8550, Japan,

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http://link.springer.com/10.1007/s10637-015-0227-5
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http://dx.doi.org/10.1007/s10637-015-0227-5DOI Listing
June 2015

A phase I study of resminostat in Japanese patients with advanced solid tumors.

Cancer Chemother Pharmacol 2015 Jun 7;75(6):1155-61. Epub 2015 Apr 7.

Department of Thoracic Oncology, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

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http://dx.doi.org/10.1007/s00280-015-2741-8DOI Listing
June 2015

Current Status of Single-Agent Phase I Trials in Japan: Toward Globalization.

J Clin Oncol 2015 Jun 27;33(18):2051-61. Epub 2015 Apr 27.

All authors: National Cancer Center Hospital, Tokyo, Japan.

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http://dx.doi.org/10.1200/JCO.2014.58.4953DOI Listing
June 2015

Patient-reported outcomes and quality of life in PROFILE 1007: a randomized trial of crizotinib compared with chemotherapy in previously treated patients with ALK-positive advanced non-small-cell lung cancer.

J Thorac Oncol 2014 Nov;9(11):1625-33

*Department of Medical Oncology, Institute of Cancer Sciences, Manchester University, and Christie Hospital NHS Foundation Trust, Manchester, United Kingdom; †Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea; ‡Department of Thoracic Oncology, Institut Gustave Roussy, Villejuif, France; §National Cancer Center Hospital, Tokyo, Japan; ‖Division of Translational & Clinical Research, Center for Lung Cancer, National Cancer Center, Goyang, South Korea; ¶Clinical Development, Pfizer Oncology, La Jolla, CA; #Biostatistics, Pfizer Global Innovative Pharma Business, New York, NY; **Global Outcomes & Evidence, Pfizer Oncology, New York, NY; ††Department of Oncology, McGill University Health Centre, Montreal, Canada; and ‡‡Hematology/Oncology, Department of Medicine, Massachusetts General Hospital, Boston, MA.

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http://dx.doi.org/10.1097/JTO.0000000000000318DOI Listing
November 2014

A phase 1 and dose-finding study of LY2523355 (litronesib), an Eg5 inhibitor, in Japanese patients with advanced solid tumors.

Cancer Chemother Pharmacol 2014 Jul 22;74(1):15-23. Epub 2014 Apr 22.

Department of Thoracic Oncology, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

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http://link.springer.com/10.1007/s00280-014-2467-z
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http://dx.doi.org/10.1007/s00280-014-2467-zDOI Listing
July 2014

Druggable oncogene fusions in invasive mucinous lung adenocarcinoma.

Clin Cancer Res 2014 Jun 11;20(12):3087-93. Epub 2014 Apr 11.

Authors' Affiliations: Divisions of Genome Biology, Genetics, and Refractory Cancer Research, National Cancer Center Research Institute, Divisions of Pathology and Clinical Laboratories, Thoracic Surgery, and Thoracic Oncology, National Cancer Center Hospital, Chuo-ku; Department of Metabolic Disorder, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo; Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto, Japan; Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland; and The Institute of Predictive and Personalized Medicine of Cancer (IMPPC), Barcelona, Spain

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-14-0107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329293PMC
June 2014

Phase 1 and dose-finding study of patritumab (U3-1287), a human monoclonal antibody targeting HER3, in Japanese patients with advanced solid tumors.

Cancer Chemother Pharmacol 2014 Mar 18;73(3):511-6. Epub 2014 Jan 18.

Department of Thoracic Oncology, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

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http://dx.doi.org/10.1007/s00280-014-2375-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931937PMC
March 2014

Secondary osteosarcoma developing 10 years after chemoradiotherapy for non-small-cell lung cancer.

Jpn J Clin Oncol 2014 Feb 13;44(2):191-4. Epub 2013 Dec 13.

*Division of Thoracic Oncology, National Cancer Center Hospital, Tsukiji 5-1-1, Chuo-ku, Tokyo 1040045, Japan.

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http://dx.doi.org/10.1093/jjco/hyt192DOI Listing
February 2014

Short hydration in chemotherapy containing cisplatin (≥75 mg/m2) for patients with lung cancer: a prospective study.

Jpn J Clin Oncol 2013 Nov 4;43(11):1105-9. Epub 2013 Sep 4.

*Division of Thoracic Oncology, National Cancer Center Hospital, Tsukiji 5-1-1, Chuo-ku, Tokyo 104-0045, Japan.

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http://dx.doi.org/10.1093/jjco/hyt122DOI Listing
November 2013

Phase I and pharmacokinetic/pharmacodynamic study of RO5126766, a first-in-class dual Raf/MEK inhibitor, in Japanese patients with advanced solid tumors.

Cancer Chemother Pharmacol 2013 Sep 17;72(3):577-84. Epub 2013 Jul 17.

Division of Thoracic Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, Japan.

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http://dx.doi.org/10.1007/s00280-013-2228-4DOI Listing
September 2013

Safety and tolerability of AZD8055 in Japanese patients with advanced solid tumors; a dose-finding phase I study.

Invest New Drugs 2013 Jun 28;31(3):677-84. Epub 2012 Jul 28.

Division of Internal Medicine and Thoracic Oncology, National Cancer Center Hospital, Tsukiji 5-1-1, Chuo-ku, Tokyo, 104-0045, Japan.

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http://dx.doi.org/10.1007/s10637-012-9860-4DOI Listing
June 2013

Phase I study of oral gemcitabine prodrug (LY2334737) in Japanese patients with advanced solid tumors.

Cancer Chemother Pharmacol 2013 Jun 25;71(6):1645-55. Epub 2013 Apr 25.

Division of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan.

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http://dx.doi.org/10.1007/s00280-013-2165-2DOI Listing
June 2013

Successful EGFR-TKI rechallenge of leptomeningeal carcinomatosis after gefitinib-induced interstitial lung disease.

Jpn J Clin Oncol 2013 Apr 13;43(4):422-5. Epub 2013 Feb 13.

Division of Internal Medicine and Thoracic Oncology, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan.

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https://academic.oup.com/jjco/article-lookup/doi/10.1093/jjc
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http://dx.doi.org/10.1093/jjco/hyt012DOI Listing
April 2013

Gender difference in hematological toxicity among lung cancer patients receiving amrubicin monotherapy.

Jpn J Clin Oncol 2012 Dec 17;42(12):1187-91. Epub 2012 Oct 17.

Division of Pharmacy, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.

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http://dx.doi.org/10.1093/jjco/hys170DOI Listing
December 2012

A phase I study of BMS-690514 in Japanese patients with advanced or metastatic solid tumors.

Cancer Chemother Pharmacol 2012 Oct 10;70(4):559-65. Epub 2012 Aug 10.

Internal Medicine and Thoracic Oncology, Division of Internal Medicine, National Cancer Center Hospital, Tsukiji, Chuo-ku, Tokyo, Japan.

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http://dx.doi.org/10.1007/s00280-012-1932-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3456941PMC
October 2012

Pharmacokinetic and pharmacodynamic study on amrubicin and amrubicinol in Japanese patients with lung cancer.

Cancer Chemother Pharmacol 2012 Apr 1;69(4):861-9. Epub 2011 Nov 1.

Department of Pharmacy, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.

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http://dx.doi.org/10.1007/s00280-011-1768-8DOI Listing
April 2012

Brain metastases after definitive concurrent chemoradiotherapy in patients with stage III lung adenocarcinoma: carcinoembryonic antigen as a potential predictive factor.

Cancer Sci 2012 Apr 20;103(4):756-9. Epub 2012 Feb 20.

Division of Internal Medicine and Thoracic Oncology, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan.

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http://dx.doi.org/10.1111/j.1349-7006.2012.02217.xDOI Listing
April 2012

Retrospective analysis of third-line and fourth-line chemotherapy for advanced non-small-cell lung cancer.

Clin Lung Cancer 2012 Jan 3;13(1):39-43. Epub 2011 Sep 3.

Division of Internal Medicine and Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan.

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http://linkinghub.elsevier.com/retrieve/pii/S152573041100156
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http://dx.doi.org/10.1016/j.cllc.2011.06.008DOI Listing
January 2012

Combination chemotherapy with carboplatin and paclitaxel for advanced thymic cancer.

Jpn J Clin Oncol 2011 Aug 7;41(8):1013-6. Epub 2011 Jul 7.

Division of Internal Medicine and Thoracic Oncology, National Cancer Center Hospital, Tsukiji 5-1-1, Chuo-ku, Tokyo 104-0045, Japan.

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http://dx.doi.org/10.1093/jjco/hyr089DOI Listing
August 2011

Amrubicin monotherapy for patients with previously treated advanced large-cell neuroendocrine carcinoma of the lung.

Jpn J Clin Oncol 2011 Jul 2;41(7):897-901. Epub 2011 Jun 2.

Division of Internal Medicine and Thoracic Oncology, National Cancer Center Hospital, Tsukiji 5-1-1, Chuo-ku, Tokyo 104-0045, Japan.

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http://dx.doi.org/10.1093/jjco/hyr065DOI Listing
July 2011

Phase I dose-escalation study and biomarker analysis of E7080 in patients with advanced solid tumors.

Clin Cancer Res 2011 Apr 3;17(8):2528-37. Epub 2011 Mar 3.

Department of Internal Medicine, National Cancer Center Hospital, Tokyo, Japan.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-2638DOI Listing
April 2011

Innovator and generic cisplatin formulations: comparison of renal toxicity.

Cancer Sci 2011 Jan 5;102(1):162-5. Epub 2010 Nov 5.

Division of Internal Medicine and Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan.

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http://dx.doi.org/10.1111/j.1349-7006.2010.01764.xDOI Listing
January 2011