Hiroshi Maegawa

Hiroshi Maegawa

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Hiroshi Maegawa

Hiroshi Maegawa

Publications by authors named "Hiroshi Maegawa"

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Advanced Technology for Gene Delivery with Homing Peptides to Spinal Cord through Systemic Circulation in Mice.

Mol Ther Methods Clin Dev 2019 Jun 10;13:474-483. Epub 2019 May 10.

Department of Stem Cell Biology and Regenerative Medicine, Shiga University of Medical Science, Shiga, Japan.

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http://dx.doi.org/10.1016/j.omtm.2019.04.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538929PMC
June 2019

Microbiome potentiates endurance exercise through intestinal acetate production.

Am J Physiol Endocrinol Metab 2019 May 12;316(5):E956-E966. Epub 2019 Mar 12.

Division of Endocrinology and Metabolism, Department of Medicine, Shiga University of Medical Science , Otsu , Japan.

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https://www.physiology.org/doi/10.1152/ajpendo.00510.2018
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http://dx.doi.org/10.1152/ajpendo.00510.2018DOI Listing
May 2019

A role for bone marrow-derived cells in diabetic nephropathy.

FASEB J 2019 Mar 29;33(3):4067-4076. Epub 2018 Nov 29.

Department of Future Basic Medicine, Nara Medical University, Nara, Japan.

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https://www.fasebj.org/doi/10.1096/fj.201801825R
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http://dx.doi.org/10.1096/fj.201801825RDOI Listing
March 2019

Efficacy of metformin on postprandial plasma triglyceride concentration by administration timing in patients with type 2 diabetes mellitus: A randomized cross-over pilot study.

J Diabetes Investig 2019 Jan 28. Epub 2019 Jan 28.

Department of Medicine, Division of Endocrinology and Metabolism, Shiga University of Medical Science, Seta-Otsu, Shiga, Japan.

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http://dx.doi.org/10.1111/jdi.13016DOI Listing
January 2019

MiR-494-3p regulates mitochondrial biogenesis and thermogenesis through PGC1-α signalling in beige adipocytes.

Sci Rep 2018 Oct 10;8(1):15096. Epub 2018 Oct 10.

Division of Endocrinology and Metabolism, Department of Medicine, Shiga University of Medical Science, Otsu, 520-2192, Japan.

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http://dx.doi.org/10.1038/s41598-018-33438-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180067PMC
October 2018

Gene Therapy for Neuropathic Pain through siRNA-IRF5 Gene Delivery with Homing Peptides to Microglia.

Mol Ther Nucleic Acids 2018 Jun 27;11:203-215. Epub 2018 Feb 27.

Department of Stem Cell Biology and Regenerative Medicine, Shiga University of Medical Science, Shiga, Japan.

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http://dx.doi.org/10.1016/j.omtn.2018.02.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992689PMC
June 2018

Definitive diagnosis of mandibular hypoplasia, deafness, progeroid features and lipodystrophy (MDPL) syndrome caused by a recurrent de novo mutation in the POLD1 gene.

Endocr J 2018 Feb 2;65(2):227-238. Epub 2017 Dec 2.

Department of Genome Medicine, National Research Institute for Child Health, Setagaya, Tokyo 157-8535, Japan.

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http://dx.doi.org/10.1507/endocrj.EJ17-0287DOI Listing
February 2018

Overexpression of acetyl CoA carboxylase β exacerbates podocyte injury in the kidney of streptozotocin-induced diabetic mice.

Biochem Biophys Res Commun 2018 01 23;495(1):1115-1121. Epub 2017 Nov 23.

Department of Medicine, Shiga University of Medical Science, Otsu, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2017.11.145DOI Listing
January 2018

Lack of O-GlcNAcylation enhances exercise-dependent glucose utilization potentially through AMP-activated protein kinase activation in skeletal muscle.

Biochem Biophys Res Commun 2018 01 15;495(2):2098-2104. Epub 2017 Dec 15.

Department of Medicine, Shiga University of Medical Science, Seta Tsukinowa, Otsu, Shiga, 520-2192, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2017.12.081DOI Listing
January 2018

Associations of serum LDL particle concentration with carotid intima-media thickness and coronary artery calcification.

J Clin Lipidol 2016 Sep-Oct;10(5):1195-1202.e1. Epub 2016 Jan 6.

Department of Public Health, Shiga University of Medical Science, Otsu, Shiga, Japan; Center for Epidemiologic Research in Asia, Shiga University of Medical Science, Otsu, Shiga, Japan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047009PMC
http://dx.doi.org/10.1016/j.jacl.2015.12.027DOI Listing
October 2017

Pivotal Role of -GlcNAc Modification in Cold-Induced Thermogenesis by Brown Adipose Tissue Through Mitochondrial Biogenesis.

Diabetes 2017 09 21;66(9):2351-2362. Epub 2017 Jun 21.

Department of Medicine, Shiga University of Medical Science, Otsu, Japan.

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http://dx.doi.org/10.2337/db16-1427DOI Listing
September 2017

Diverse metabolic effects of O-GlcNAcylation in the pancreas but limited effects in insulin-sensitive organs in mice.

Diabetologia 2017 09 22;60(9):1761-1769. Epub 2017 Jun 22.

Department of Medicine, Shiga University of Medical Science, Tsukinowa-cho, Seta, Otsu, Shiga, 520-2192, Japan.

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http://dx.doi.org/10.1007/s00125-017-4327-yDOI Listing
September 2017

Amla Enhances Mitochondrial Spare Respiratory Capacity by Increasing Mitochondrial Biogenesis and Antioxidant Systems in a Murine Skeletal Muscle Cell Line.

Oxid Med Cell Longev 2016 2;2016:1735841. Epub 2016 Jun 2.

Department of Medicine, Division of Endocrinology and Metabolism, Shiga University of Medical Science, Tsukinowa, Seta, Otsu, Shiga 520-2192, Japan.

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http://dx.doi.org/10.1155/2016/1735841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909908PMC
July 2017

Metabolic and hemodynamic effects of sodium-dependent glucose cotransporter 2 inhibitors on cardio-renal protection in the treatment of patients with type 2 diabetes mellitus.

J Diabetes Investig 2017 Jul 12;8(4):416-427. Epub 2017 May 12.

Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan.

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http://dx.doi.org/10.1111/jdi.12644DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497037PMC
July 2017

Acute Effect of Metformin on Postprandial Hypertriglyceridemia through Delayed Gastric Emptying.

Int J Mol Sci 2017 Jun 16;18(6). Epub 2017 Jun 16.

Division of Endocrinology and Metabolism, Department of Medicine, Shiga University of Medical Science, Seta-Otsu 520-2192, Shiga, Japan.

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http://dx.doi.org/10.3390/ijms18061282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486104PMC
June 2017

Comparison of baseline characteristics and clinical course in Japanese patients with type 2 diabetes among whom different types of oral hypoglycemic agents were chosen by diabetes specialists as initial monotherapy (JDDM 42).

Medicine (Baltimore) 2017 Feb;96(7):e6122

aNiigata University Faculty of Medicine, Niigata bJiyugaoka Medical Clinic, Hokkaido cKyoto University Hospital, Kyoto dUniversity of Tsukuba, Ibaraki eShiga University of Medical Science, Shiga fKawai Clinic, Ibaraki, Japan.

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http://dx.doi.org/10.1097/MD.0000000000006122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319527PMC
February 2017

Emerging role of mammalian autophagy in ketogenesis to overcome starvation.

Autophagy 2016 ;12(4):709-10

a Department of Medicine , Shiga University of Medical Science , Tsukinowa-Cho, Seta, Otsu, Shiga , Japan.

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http://dx.doi.org/10.1080/15548627.2016.1151597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835954PMC
December 2016

MicroRNA148b-3p inhibits mTORC1-dependent apoptosis in diabetes by repressing TNFR2 in proximal tubular cells.

Kidney Int 2016 12 31;90(6):1211-1225. Epub 2016 Aug 31.

Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan.

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http://dx.doi.org/10.1016/j.kint.2016.06.036DOI Listing
December 2016

Concentrations of Water-Soluble Vitamins in Blood and Urinary Excretion in Patients with Diabetes Mellitus.

Nutr Metab Insights 2016 1;9:85-92. Epub 2016 Nov 1.

Department of Nutrition, School of Human Cultures, The University of Shiga Prefecture, Hikone, Shiga, Japan.

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http://dx.doi.org/10.4137/NMI.S40595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5091094PMC
November 2016

Stearoyl-CoA Desaturase-1 Protects Cells against Lipotoxicity-Mediated Apoptosis in Proximal Tubular Cells.

Int J Mol Sci 2016 Nov 9;17(11). Epub 2016 Nov 9.

Department of Medicine, Shiga University of Medical Science, Tsukinowa-cho, Seta, Otsu, Shiga 520-2192, Japan.

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http://dx.doi.org/10.3390/ijms17111868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133868PMC
November 2016

Relationship of Insulin Resistance to Prevalence and Progression of Coronary Artery Calcification Beyond Metabolic Syndrome Components: Shiga Epidemiological Study of Subclinical Atherosclerosis.

Arterioscler Thromb Vasc Biol 2016 08 9;36(8):1703-8. Epub 2016 Jun 9.

From the Department of Cardiology, Tokyo Medical and Dental University, Tokyo, Japan (M.Y.); Center for Epidemiologic Research in Asia (M.Y., K.M., A.K., H.A., H.U.), Department of Public Health (M.Y., T.H., K.M., S.K., M.Z., A.K., S.T., A.F., H.A., H.U.), Department of Cardiovascular and Respiratory Medicine (T.H., S.T., M.H.), Division of Endocrinology and Metabolism, Department of Medicine (I.M., H.M.), Shiga University of Medical Science, Otsu, Japan; Department of Environmental Medicine and Public Health, Faculty of Medicine, Shimane University, Izumo, Japan (T.H.); Department of Preventive Medicine and Public Health, Faculty of Medicine, Fukuoka University, Fukuoka, Japan (H.A.); and Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA (A.S.).

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http://dx.doi.org/10.1161/ATVBAHA.116.307612DOI Listing
August 2016

Emerging role of podocyte autophagy in the progression of diabetic nephropathy.

Autophagy 2015 ;11(12):2385-6

a Department of Medicine ; Shiga University of Medical Science ; Otsu; Shiga , Japan.

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http://dx.doi.org/10.1080/15548627.2015.1115173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835189PMC
July 2016

Population Pharmacokinetics and Therapeutic Efficacy of Febuxostat in Patients with Severe Renal Impairment.

Pharmacology 2015 11;96(1-2):90-8. Epub 2015 Jul 11.

Department of Pharmacy, Shiga University of Medical Science Hospital, Otsu, Shiga, Japan.

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http://dx.doi.org/10.1159/000434633DOI Listing
May 2016

Replication Study in a Japanese Population to Evaluate the Association between 10 SNP Loci, Identified in European Genome-Wide Association Studies, and Type 2 Diabetes.

PLoS One 2015 7;10(5):e0126363. Epub 2015 May 7.

Laboratory for Endocrinology, Metabolism and Kidney Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Department of Advanced Genomic and Laboratory Medicine, Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0126363PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423838PMC
April 2016

[Management for diabetes mellitus to prevent its complications].

Authors:
Hiroshi Maegawa

Nihon Rinsho 2016 Apr;74 Suppl 2:40-5

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April 2016

Association between attentional function and postural instability in Japanese older patients with diabetes mellitus.

Diabetol Int 2016 Mar 18;7(1):83-88. Epub 2015 Aug 18.

1Department of Clinical Nursing, Shiga University of Medical Science, Tsukinowa-cho Seta, Otsu, Shiga 520-2192 Japan.

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http://dx.doi.org/10.1007/s13340-015-0231-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224902PMC
March 2016

MicroRNA-494 plays a role in fiber type-specific skeletal myogenesis in human induced pluripotent stem cells.

Biochem Biophys Res Commun 2015 Dec 4-11;468(1-2):208-13. Epub 2015 Oct 28.

Division of Pharmacology, Department of Medicine, Shiga University of Medical Science, Japan.

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https://linkinghub.elsevier.com/retrieve/pii/S0006291X153082
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http://dx.doi.org/10.1016/j.bbrc.2015.10.128DOI Listing
March 2016

Renoprotective effect of DPP-4 inhibitors against free fatty acid-bound albumin-induced renal proximal tubular cell injury.

Biochem Biophys Res Commun 2016 Feb 21;470(3):539-545. Epub 2016 Jan 21.

Department of Medicine, Shiga University of Medical Science, Tsukinokawa-Cho, Seta, Otsu, Shiga, Japan.

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https://linkinghub.elsevier.com/retrieve/pii/S0006291X163010
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http://dx.doi.org/10.1016/j.bbrc.2016.01.109DOI Listing
February 2016

[Infection complicated with diabetes mellitus].

Nihon Rinsho 2015 Dec;73(12):2084-90

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December 2015

[Hypertension and diabetes mellitus].

Nihon Rinsho 2015 Nov;73(11):1885-90

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November 2015

Lamp-2 deficiency prevents high-fat diet-induced obese diabetes via enhancing energy expenditure.

Biochem Biophys Res Commun 2015 Sep 10;465(2):249-55. Epub 2015 Aug 10.

Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2015.08.010DOI Listing
September 2015

Epidermis-dermis junction as a novel location for bone marrow-derived cells to reside in response to ionizing radiation.

Biochem Biophys Res Commun 2015 Jun 25;461(4):695-701. Epub 2015 Apr 25.

Division of Anatomy and Cell Biology, Shiga University of Medical Science, Shiga, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2015.04.094DOI Listing
June 2015

Role of nutrient-sensing signals in the pathogenesis of diabetic nephropathy.

Biomed Res Int 2014 14;2014:315494. Epub 2014 Jul 14.

Department of Medicine, Shiga University of Medical Science, Tsukinowa-Cho, Seta, Otsu, Shiga 520-2192, Japan.

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http://dx.doi.org/10.1155/2014/315494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122096PMC
May 2015

Multiple osteoporotic fractures in a patient with CKD stage G3b.

Kidney Int 2015 May;87(5):1077

Department of Internal Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan.

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https://linkinghub.elsevier.com/retrieve/pii/S00852538153008
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http://dx.doi.org/10.1038/ki.2013.232DOI Listing
May 2015

High-density lipoprotein particle concentration and subclinical atherosclerosis of the carotid arteries in Japanese men.

Atherosclerosis 2015 Apr 31;239(2):444-50. Epub 2015 Jan 31.

Department of Public Health, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga, 520-2192, Japan; Center for Epidemiologic Research in Asia, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga, 520-2192, Japan.

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http://dx.doi.org/10.1016/j.atherosclerosis.2015.01.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361286PMC
April 2015

Use of MRI signal intensity of extraocular muscles to evaluate methylprednisolone pulse therapy in thyroid-associated ophthalmopathy.

Jpn J Ophthalmol 2015 Mar 3;59(2):124-30. Epub 2014 Dec 3.

Department of Ophthalmology, Shiga University of Medical Science, Seta, Tsukinowa-cho, Otsu, Shiga, 520-2192, Japan,

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http://dx.doi.org/10.1007/s10384-014-0365-xDOI Listing
March 2015

A high-fiber, low-fat diet improves periodontal disease markers in high-risk subjects: a pilot study.

Nutr Res 2014 Jun 11;34(6):491-8. Epub 2014 Jun 11.

Division of Endocrinology and Metabolism, Department of Medicine, Shiga University of Medical Science, Seta-Tsukinowa-Cho, Otsu, Shiga 520-2192, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.nutres.2014.06.001DOI Listing
June 2014