Hiroshi Maeda

Hiroshi Maeda

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Hiroshi Maeda

Hiroshi Maeda

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Childhood-onset multifocal motor neuropathy with IgM antibodies to GM2 and GalNac-GD1a.

Brain Dev 2020 Jan 12;42(1):88-92. Epub 2019 Sep 12.

Department of Pediatrics, Kyoto Prefectural University of Medicine, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.braindev.2019.08.013DOI Listing
January 2020

Exposure-Response Analysis for Mogamulizumab in Adults With Cutaneous T-Cell Lymphoma.

J Clin Pharmacol 2020 Jan 16;60(1):50-57. Epub 2019 Dec 16.

Kyowa Kirin Pharmaceutical Development, Inc, Princeton, New Jersey, USA.

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http://dx.doi.org/10.1002/jcph.1548DOI Listing
January 2020

Population Pharmacokinetic Modeling of Mogamulizumab in Adults With Cutaneous T-Cell Lymphoma or Adult T-Cell Lymphoma.

J Clin Pharmacol 2020 Jan 16;60(1):58-66. Epub 2019 Dec 16.

Kyowa Kirin Pharmaceutical Development, Inc., Princeton, New Jersey, USA.

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http://dx.doi.org/10.1002/jcph.1564DOI Listing
January 2020

Synthesis and evaluation of styrene-maleic acid copolymer conjugated amphotericin B.

Int J Pharm 2019 Dec 22;572:118719. Epub 2019 Oct 22.

BioDynamics Research Foundation, 1-24-6 Kuwamizu, Chuo-ku, Kumamoto 862-0954, Japan.

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http://dx.doi.org/10.1016/j.ijpharm.2019.118719DOI Listing
December 2019

Harnessing evolutionary diversification of primary metabolism for plant synthetic biology.

Authors:
Hiroshi A Maeda

J Biol Chem 2019 Nov 26;294(45):16549-16566. Epub 2019 Sep 26.

Department of Botany, University of Wisconsin-Madison, Madison, Wisconsin 53706

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http://dx.doi.org/10.1074/jbc.REV119.006132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851331PMC
November 2019

Superior Penetration and Cytotoxicity of HPMA Copolymer Conjugates of Pirarubicin in Tumor Cell Spheroid.

Mol Pharm 2019 08 11;16(8):3452-3459. Epub 2019 Jul 11.

Department of Microbiology , Kumamoto University School of Medical Sciences , Kumamoto , Japan.

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http://dx.doi.org/10.1021/acs.molpharmaceut.9b00248DOI Listing
August 2019

Augmentation of EPR Effect and Efficacy of Anticancer Nanomedicine by Carbon Monoxide Generating Agents.

Pharmaceutics 2019 Jul 16;11(7). Epub 2019 Jul 16.

Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556, Japan.

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http://dx.doi.org/10.3390/pharmaceutics11070343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680399PMC
July 2019

Evolutionary Diversification of Primary Metabolism and Its Contribution to Plant Chemical Diversity.

Authors:
Hiroshi A Maeda

Front Plant Sci 2019 10;10:881. Epub 2019 Jul 10.

Department of Botany, University of Wisconsin-Madison, Madison, WI, United States.

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http://dx.doi.org/10.3389/fpls.2019.00881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6635470PMC
July 2019

Singlet oxygen phosphorescence detection in vivo identifies PDT-induced anoxia in solid tumors.

Photochem Photobiol Sci 2019 Jun;18(6):1304-1314

Photobiophysics, Institute of Physics, Humboldt University of Berlin, Newtonstr. 15, 12489 Berlin, Germany.

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http://xlink.rsc.org/?DOI=C8PP00570B
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http://dx.doi.org/10.1039/c8pp00570bDOI Listing
June 2019

Biochemical characterization of TyrA dehydrogenases from Saccharomyces cerevisiae (Ascomycota) and Pleurotus ostreatus (Basidiomycota).

Arch Biochem Biophys 2019 04 13;665:12-19. Epub 2019 Feb 13.

Department of Botany, University of Wisconsin-Madison, Madison, WI, 53706, USA.

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http://dx.doi.org/10.1016/j.abb.2019.02.005DOI Listing
April 2019

Imbalance of tyrosine by modulating TyrA arogenate dehydrogenases impacts growth and development of Arabidopsis thaliana.

Plant J 2019 03 18;97(5):901-922. Epub 2019 Jan 18.

Department of Botany, University of Wisconsin-Madison, 430 Lincoln Drive, Madison, WI, 53706, USA.

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http://dx.doi.org/10.1111/tpj.14169DOI Listing
March 2019

TAT1 and TAT2 tyrosine aminotransferases have both distinct and shared functions in tyrosine metabolism and degradation in .

J Biol Chem 2019 03 10;294(10):3563-3576. Epub 2019 Jan 10.

From the Department of Botany, University of Wisconsin-Madison, Madison, Wisconsin 53706,

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http://www.jbc.org/lookup/doi/10.1074/jbc.RA118.006539
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http://dx.doi.org/10.1074/jbc.RA118.006539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416433PMC
March 2019

Selective growth inhibition of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans by antisense peptide nucleic acids.

Mol Cell Probes 2019 02 22;43:45-49. Epub 2018 Nov 22.

Department of Endodontics, Osaka Dental University, 8-1 Kuzuhahanazonocho, Hirakata, Osaka, 573-1121, Japan.

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https://linkinghub.elsevier.com/retrieve/pii/S08908508183026
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http://dx.doi.org/10.1016/j.mcp.2018.11.006DOI Listing
February 2019

The renaissance of comparative biochemistry.

Am J Bot 2019 01 10;106(1):3-13. Epub 2019 Jan 10.

Department of Biochemistry and Center for Plant Biology, Purdue University, West Lafayette, IN, USA.

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http://doi.wiley.com/10.1002/ajb2.1216
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http://dx.doi.org/10.1002/ajb2.1216DOI Listing
January 2019

A case of pseudohypoparathyroidism type Ia with a novel frameshift mutation in the gene: early diagnosis of osteoma cutis by skin biopsy.

Clin Pediatr Endocrinol 2019 31;28(1):15-18. Epub 2019 Jan 31.

Department of Pediatrics, North Medical Center, Kyoto Prefectural University of Medicine, Kyoto, Japan.

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https://www.jstage.jst.go.jp/article/cpe/28/1/28_2018-0027/_
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http://dx.doi.org/10.1297/cpe.28.15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356092PMC
January 2019

Augmentation of the Enhanced Permeability and Retention Effect with Nitric Oxide-Generating Agents Improves the Therapeutic Effects of Nanomedicines.

Mol Cancer Ther 2018 12 19;17(12):2643-2653. Epub 2018 Sep 19.

Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.

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http://dx.doi.org/10.1158/1535-7163.MCT-18-0696DOI Listing
December 2018

Targeted literature review of the global burden of gastric cancer.

Ecancermedicalscience 2018 26;12:883. Epub 2018 Nov 26.

University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030 USA.

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http://dx.doi.org/10.3332/ecancer.2018.883DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345079PMC
November 2018

A kinematic and kinetic analysis of the hip and knee joints in patients with posterior tibialis tendon dysfunction; comparison with healthy age-matched controls.

Gait Posture 2018 10 5;66:228-235. Epub 2018 Sep 5.

Department of Rehabilitation Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kajii-cho 465, Kawaramachi-Hirokoji, Kamigyo-ku, 602-8566 Kyoto, Japan; Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kajii-cho 465, Kawaramachi-Hirokoji, Kamigyo-ku, 602-8566, Kyoto, Japan; Rehabilitation Unit, Kyoto Prefectural University Hospital 'Kajii-cho 465, Kawaramachi-Hirokoji, Kamigyo-ku, 602-8566, Kyoto, Japan.

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http://dx.doi.org/10.1016/j.gaitpost.2018.08.040DOI Listing
October 2018

N-(2-hydroxypropyl)methacrylamide polymer conjugated pyropheophorbide-a, a promising tumor-targeted theranostic probe for photodynamic therapy and imaging.

Eur J Pharm Biopharm 2018 Sep 8;130:165-176. Epub 2018 Jun 8.

Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556, Japan; BioDynamics Research Foundation, Kumamoto 862-0954, Japan; Osaka University, Graduate School of Medicine, Suita, Osaka, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.ejpb.2018.06.005DOI Listing
September 2018

Polymer therapeutics and the EPR effect.

Authors:
Hiroshi Maeda

J Drug Target 2017 Nov - Dec;25(9-10):781-785. Epub 2017 Oct 9.

a Kumamoto University and BioDynamic Research Foundation , Kumamoto , Japan.

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http://dx.doi.org/10.1080/1061186X.2017.1365878DOI Listing
June 2018

Tyrosine biosynthesis, metabolism, and catabolism in plants.

Phytochemistry 2018 May 23;149:82-102. Epub 2018 Feb 23.

Department of Botany, University of Wisconsin-Madison, Madison, WI 53706, USA. Electronic address:

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http://dx.doi.org/10.1016/j.phytochem.2018.02.003DOI Listing
May 2018

The Rise of the Current Mortality Pattern of the United States, 1890-1930.

Authors:
Hiroshi Maeda

Am J Epidemiol 2018 04;187(4):639-646

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http://dx.doi.org/10.1093/aje/kwx203DOI Listing
April 2018

Structural basis for substrate recognition and inhibition of prephenate aminotransferase from Arabidopsis.

Plant J 2018 04 14;94(2):304-314. Epub 2018 Mar 14.

Department of Biology, Washington University in St Louis, St Louis, MO, 63130, USA.

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http://dx.doi.org/10.1111/tpj.13856DOI Listing
April 2018

Analyses of repeated failures in cancer therapy for solid tumors: poor tumor-selective drug delivery, low therapeutic efficacy and unsustainable costs.

Clin Transl Med 2018 Mar 1;7(1):11. Epub 2018 Mar 1.

Inflammation, Aging and Cancer, National Cancer Institute, The National Institutes of Health, Bethesda, MD, USA.

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https://clintransmed.springeropen.com/articles/10.1186/s4016
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http://dx.doi.org/10.1186/s40169-018-0185-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852245PMC
March 2018

A Simple Method of Interpretating the Effects of Electric Charges on the Volume Phase Transition of Thermosensitive Gels.

Gels 2018 Mar 19;4(1). Epub 2018 Mar 19.

Osaka Research Institute of Industrial Science and Technology, 1-6-50 Morinomiya, Joto-ku, Osaka 536-8553, Japan.

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http://dx.doi.org/10.3390/gels4010024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318622PMC
March 2018

The Criteria of Thickened Liquid for Dysphagia Management in Japan.

Dysphagia 2018 Feb 30;33(1):26-32. Epub 2017 Aug 30.

Department of Health Sciences, Prefectural University of Hiroshima, 1-1-71 Ujina-Higashi, Minami-ku, Hiroshima, 734-8558, Japan.

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http://dx.doi.org/10.1007/s00455-017-9827-xDOI Listing
February 2018

Relaxation of tyrosine pathway regulation underlies the evolution of betalain pigmentation in Caryophyllales.

New Phytol 2018 01 9;217(2):896-908. Epub 2017 Oct 9.

Department of Botany, University of Wisconsin-Madison, Madison, WI, 53706, USA.

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http://dx.doi.org/10.1111/nph.14822DOI Listing
January 2018

HPMA copolymer conjugate with pirarubicin: In vitro and ex vivo stability and drug release study.

Int J Pharm 2018 Jan 10;536(1):108-115. Epub 2017 Nov 10.

Biodynamic Research Foundation, Kenshin Bldg 3F, Kuwamizu 1-chome, 24-6 Chuo-ku, Kumamoto, 862-0954, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.ijpharm.2017.11.011DOI Listing
January 2018

IS1598 (IsPg4) distributed to abscess-forming strains of Porphyromonas gingivalis may enhance virulence through upregulation of nrdD-like gene expression.

New Microbiol 2018 Jan;41(1):52-60

Department of Patho-Physiology, Division of Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences 2-5-1 Shikata-cho, Kita-Ku, Okayama 700-8525, Ja.

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January 2018

Aggregatibacter actinomycetemcomitans regulates the expression of integrins and reduces cell adhesion via integrin α5 in human gingival epithelial cells.

Mol Cell Biochem 2017 Dec 7;436(1-2):39-48. Epub 2017 Jun 7.

Department of Pathophysiology-Periodontal Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8525, Japan.

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http://dx.doi.org/10.1007/s11010-017-3076-zDOI Listing
December 2017

Conserved Molecular Mechanism of TyrA Dehydrogenase Substrate Specificity Underlying Alternative Tyrosine Biosynthetic Pathways in Plants and Microbes.

Front Mol Biosci 2017 7;4:73. Epub 2017 Nov 7.

Department of Botany, University of Wisconsin-Madison, Madison, WI, United States.

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http://dx.doi.org/10.3389/fmolb.2017.00073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681985PMC
November 2017

Draft Genome Sequences of Strains 310a and 310b.

Genome Announc 2017 Nov 22;5(47). Epub 2017 Nov 22.

Department of Oral Biology, Rutgers School of Dental Medicine, Newark, New Jersey, USA

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http://dx.doi.org/10.1128/genomeA.01282-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701468PMC
November 2017

Monoamine oxidase B oxidizes a novel multikinase inhibitor KW-2449 to its iminium ion and aldehyde oxidase further converts it to the oxo-piperazine form in human.

Drug Metab Pharmacokinet 2017 Oct 22;32(5):255-264. Epub 2017 Jun 22.

Translational Research Unit, Research and Development Division, Kyowa Hakko Kirin Co., Ltd., 1188 Shimotogari, Sunto-gun, Nagaizumi-cho, Shizuoka 411-8731, Japan.

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http://dx.doi.org/10.1016/j.dmpk.2017.06.002DOI Listing
October 2017

A spontaneous basal cell carcinoma with pulmonary metastasis in a 6-week-old SD rat.

J Toxicol Pathol 2017 Oct 11;30(4):323-326. Epub 2017 Jun 11.

Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd., 2438 Miyanoura, Kagoshima 891-1394, Japan.

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http://dx.doi.org/10.1293/tox.2017-0016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660954PMC
October 2017

Improved anticancer effects of albumin-bound paclitaxel nanoparticle via augmentation of EPR effect and albumin-protein interactions using S-nitrosated human serum albumin dimer.

Biomaterials 2017 Sep 22;140:162-169. Epub 2017 Jun 22.

Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2017.06.021DOI Listing
September 2017

Molecular basis of the evolution of alternative tyrosine biosynthetic routes in plants.

Nat Chem Biol 2017 Sep 26;13(9):1029-1035. Epub 2017 Jun 26.

Department of Botany, University of Wisconsin-Madison, Madison, Wisconsin, USA.

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http://dx.doi.org/10.1038/nchembio.2414DOI Listing
September 2017

Comparison of the pharmacological and biological properties of HPMA copolymer-pirarubicin conjugates: A single-chain copolymer conjugate and its biodegradable tandem-diblock copolymer conjugate.

Eur J Pharm Sci 2017 Aug 18;106:10-19. Epub 2017 May 18.

Institute for Drug Delivery Science, Sojo University, Ikeda 4-22-1, Nishi-ku, Kumamoto 860-0082, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.ejps.2017.05.031DOI Listing
August 2017

Luteolin attenuates interleukin-6-mediated astrogliosis in human iPSC-derived neural aggregates: A candidate preventive substance for maternal immune activation-induced abnormalities.

Neurosci Lett 2017 Jul 6;653:296-301. Epub 2017 Jun 6.

Department of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo, Kyoto 602-8566, Japan.

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http://dx.doi.org/10.1016/j.neulet.2017.06.004DOI Listing
July 2017

Rho-kinase regulates extracellular matrix-mediated osteogenic differentiation of periodontal ligament cells.

Cell Biol Int 2017 Jun 2;41(6):651-658. Epub 2017 May 2.

Department of Pathophysiology-Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8525, Japan.

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http://dx.doi.org/10.1002/cbin.10769DOI Listing
June 2017

Deletion of admB gene encoding a fungal ADAM affects cell wall construction in Aspergillus oryzae.

Biosci Biotechnol Biochem 2017 May 6;81(5):1041-1050. Epub 2017 Jan 6.

a Department of Applied Life Science, The United Graduate School of Agricultural Science , Tokyo University of Agriculture and Technology , Fuchu , Japan.

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http://dx.doi.org/10.1080/09168451.2016.1270741DOI Listing
May 2017

Longitudinal change in white matter in preterm infants without magnetic resonance imaging abnormalities: Assessment of serial diffusion tensor imaging and their relationship to neurodevelopmental outcomes.

Brain Dev 2017 Jan 16;39(1):40-47. Epub 2016 Aug 16.

Department of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kajii-cho Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan.

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http://dx.doi.org/10.1016/j.braindev.2016.07.007DOI Listing
January 2017

Styrene-maleic acid-copolymer conjugated zinc protoporphyrin as a candidate drug for tumor-targeted therapy and imaging.

J Drug Target 2016 24;24(5):399-407. Epub 2015 Aug 24.

a Research Institute of Drug Delivery Sciences .

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http://dx.doi.org/10.3109/1061186X.2015.1077851DOI Listing
December 2016

Biochemical properties and subcellular localization of tyrosine aminotransferases in Arabidopsis thaliana.

Phytochemistry 2016 Dec 7;132:16-25. Epub 2016 Oct 7.

Department of Botany, University of Wisconsin-Madison, Madison, WI 53706, USA. Electronic address:

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http://dx.doi.org/10.1016/j.phytochem.2016.09.007DOI Listing
December 2016

Subwavelength InSb-based Slot wavguides for THz transport: concept and practical implementations.

Sci Rep 2016 12 7;6:38784. Epub 2016 Dec 7.

Department of Electrical and Computer Engineering, Dalhousie University, Halifax, NS B3J 2X4, Canada.

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http://dx.doi.org/10.1038/srep38784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5141467PMC
December 2016

Pronounced Cellular Uptake of Pirarubicin versus That of Other Anthracyclines: Comparison of HPMA Copolymer Conjugates of Pirarubicin and Doxorubicin.

Mol Pharm 2016 12 21;13(12):4106-4115. Epub 2016 Nov 21.

Research Institute for Drug Delivery Science, Sojo University , Ikeda 4-22-1, Nishi-ku, Kumamoto 860-0082, Japan.

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http://dx.doi.org/10.1021/acs.molpharmaceut.6b00697DOI Listing
December 2016

Enhancement of Tumor-Targeted Delivery of Bacteria with Nitroglycerin Involving Augmentation of the EPR Effect.

Methods Mol Biol 2016 ;1409:9-23

Research Institute for Drug Delivery System, Sojo University, 4-22-1 Ikeda, Nishi Ward, Kumamoto, Kumamoto Prefecture, 860-0082, Japan.

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http://dx.doi.org/10.1007/978-1-4939-3515-4_2DOI Listing
November 2016

Smad2 overexpression enhances adhesion of gingival epithelial cells.

Arch Oral Biol 2016 Nov 29;71:46-53. Epub 2016 Jun 29.

Department of Pathophysiology - Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8525, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.archoralbio.2016.06.025DOI Listing
November 2016

A novel non-thermostable deuterolysin from Aspergillus oryzae.

Biosci Biotechnol Biochem 2016 Sep 6;80(9):1813-9. Epub 2016 Apr 6.

a Department of Applied Biological Chemistry, The Graduate School of Agriculture , Tokyo University of Agriculture and Technology , Fuchu , Tokyo , Japan.

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http://dx.doi.org/10.1080/09168451.2016.1166933DOI Listing
September 2016

Three extracellular dipeptidyl peptidases found in Aspergillus oryzae show varying substrate specificities.

Appl Microbiol Biotechnol 2016 Jun 5;100(11):4947-58. Epub 2016 Feb 5.

Department of Applied Molecular Biology and Biochemistry, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo, 1838509, Japan.

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http://dx.doi.org/10.1007/s00253-016-7339-5DOI Listing
June 2016

Lignin biosynthesis: Tyrosine shortcut in grasses.

Authors:
Hiroshi A Maeda

Nat Plants 2016 06 3;2(6):16080. Epub 2016 Jun 3.

Department of Botany, University of Wisconsin-Madison, 430 Lincoln Drive, Madison, Wisconsin 53706, USA.

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http://dx.doi.org/10.1038/nplants.2016.80DOI Listing
June 2016

[Missile-Type Tumor-Targeting Polymer Drug, P-THP, Seeks Tumors via Three Different Steps Based on the EPR Effect].

Gan To Kagaku Ryoho 2016 May;43(5):549-57

Institute of Drug Delivery Science, Sojo University.

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May 2016

pH-sensitive polymeric cisplatin-ion complex with styrene-maleic acid copolymer exhibits tumor-selective drug delivery and antitumor activity as a result of the enhanced permeability and retention effect.

Colloids Surf B Biointerfaces 2016 Feb 23;138:128-37. Epub 2015 Nov 23.

Research Institution of DDS, Sojo University, Ikeda 4-22-1, Nishi-ku, Kumamoto 860-0082, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.colsurfb.2015.11.032DOI Listing
February 2016

Water soluble PEG-conjugate of xanthine oxidase inhibitor, PEG-AHPP micelles, as a novel therapeutic for ROS related inflammatory bowel diseases.

J Control Release 2016 Feb 29;223:188-196. Epub 2015 Dec 29.

DDS Research Institute, Sojo University, Ikeda 4-22-1, Nishi-ku, Kumamoto 860-0082, Japan; Laboratory of Microbiology & Oncology, Faculty of Pharmaceutical Sciences, Sojo University, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2015.12.049DOI Listing
February 2016

Cloning a neutral protease of Clostridium histolyticum, determining its substrate specificity, and designing a specific substrate.

Appl Microbiol Biotechnol 2015 Dec 26;99(24):10489-99. Epub 2015 Aug 26.

New Industry Creation Hatchery Center, Tohoku University, 6-6-10 Aramaki Aza Aoba, Aoba-ku, Sendai, Miyagi, 980-0872, Japan.

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http://link.springer.com/content/pdf/10.1007%2Fs00253-015-69
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http://link.springer.com/10.1007/s00253-015-6923-4
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http://dx.doi.org/10.1007/s00253-015-6923-4DOI Listing
December 2015

S-Nitrosated human serum albumin dimer as novel nano-EPR enhancer applied to macromolecular anti-tumor drugs such as micelles and liposomes.

J Control Release 2015 Nov 22;217:1-9. Epub 2015 Aug 22.

Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan; Center for Clinical Pharmaceutical Science, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2015.08.036DOI Listing
November 2015

Photodynamic therapy and imaging based on tumor-targeted nanoprobe, polymer-conjugated zinc protoporphyrin.

Future Sci OA 2015 Nov 1;1(3):FSO4. Epub 2015 Nov 1.

Research Institute for Drug Delivery Science, Sojo University, Ikeda 4-22-1, Kumamoto 860-0082, Japan; Research Institute for Drug Delivery Science, Sojo University, Ikeda 4-22-1, Kumamoto 860-0082, Japan.

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http://dx.doi.org/10.4155/fso.15.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137960PMC
November 2015

Analysis of the relationship between periodontal disease and atherosclerosis within a local clinical system: a cross-sectional observational pilot study.

Odontology 2015 Sep 14;103(3):314-21. Epub 2014 Aug 14.

Department of Pathophysiology-Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-Cho, Kita-Ku, Okayama, 700-8525, Japan.

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http://dx.doi.org/10.1007/s10266-014-0172-3DOI Listing
September 2015

Isolation and characterization of monoclonal antibodies specific for chondroitin sulfate E.

Glycobiology 2015 Sep 2;25(9):953-62. Epub 2015 Jun 2.

Department of Biochemistry, School of Pharmaceutical Science, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka-shi, Shizuoka 422-8526, Japan

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September 2015

Toward a full understanding of the EPR effect in primary and metastatic tumors as well as issues related to its heterogeneity.

Authors:
Hiroshi Maeda

Adv Drug Deliv Rev 2015 Aug 9;91:3-6. Epub 2015 Jan 9.

Institute of Drug Delivery Science, Sojo University, Ikeda 4-22-1, Nishi-ku, Kumamoto 860-0082, Japan. Electronic address:

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August 2015

Osteogenic differentiation regulated by Rho-kinase in periodontal ligament cells.

Differentiation 2014 Sep-Oct;88(2-3):33-41. Epub 2014 Sep 29.

Department of Pathophysiology-Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8525, Japan. Electronic address:

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July 2015

Synergistic Effect of Neutral Protease and Clostripain on Rat Pancreatic Islet Isolation.

Transplantation 2015 Jul;99(7):1349-55

1Division of Advanced Surgical Science and Technology, Tohoku University School of Medicine, Sendai, Japan. 2New Industry Creation Hatchery Center, Tohoku University, Sendai, Japan. 3Graduate school of Agricultural Science, Tokyo University of Agriculture and Technology, Tokyo, Japan. 4Graduate school of Biomedical Engineering, Tohoku University, Sendai, Japan. 5Department of Integrative Genomics, Tohoku Medical Megabank Organization (ToMMO), Tohoku University School of Medicine, Sendai, Japan. 6Department of Biochemistry, Center for Regulatory Epigenome and Diseases, Tohoku University Graduated School of Medicine, Sendai, Japan.

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July 2015

Low-grade intraventricular hemorrhage disrupts cerebellar white matter in preterm infants: evidence from diffusion tensor imaging.

Neuroradiology 2015 May 18;57(5):507-14. Epub 2015 Jan 18.

Department of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan.

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May 2015

Diversity in mRNA expression of the serine-type carboxypeptidase ocpG in Aspergillus oryzae through intron retention.

Biosci Biotechnol Biochem 2014 24;78(8):1328-36. Epub 2014 Jun 24.

a Department of Agriscience and Bioscience , Tokyo University of Agriculture and Technology , Tokyo , Japan.

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April 2015

Ionic interaction of positive amino acid residues of fungal hydrophobin RolA with acidic amino acid residues of cutinase CutL1.

Mol Microbiol 2015 Apr 11;96(1):14-27. Epub 2015 Feb 11.

Microbial Genomics Laboratory, New Industry Creation Hatchery Center, Tohoku University, Sendai, Miyagi, 981-8555, Japan.

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http://doi.wiley.com/10.1111/mmi.12915
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April 2015

Synthesis and therapeutic effect of styrene-maleic acid copolymer-conjugated pirarubicin.

Cancer Sci 2015 Mar 3;106(3):270-8. Epub 2015 Feb 3.

Institute for Drug Delivery Science, Sojo University, Kumamoto, Japan; Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376435PMC
March 2015

Poly-S-nitrosated human albumin enhances the antitumor and antimetastasis effect of bevacizumab, partly by inhibiting autophagy through the generation of nitric oxide.

Cancer Sci 2015 Feb 28;106(2):194-200. Epub 2015 Jan 28.

Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan; Center for Clinical Pharmaceutical Science, Kumamoto University, Kumamoto, Japan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4399024PMC
February 2015

Comparison between linear and star-like HPMA conjugated pirarubicin (THP) in pharmacokinetics and antitumor activity in tumor bearing mice.

Eur J Pharm Biopharm 2015 Feb 8;90:90-6. Epub 2014 Nov 8.

Research Institute for Drug Delivery Science, Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan. Electronic address:

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February 2015

Non-plastidic, tyrosine-insensitive prephenate dehydrogenases from legumes.

Nat Chem Biol 2015 Jan 17;11(1):52-7. Epub 2014 Nov 17.

Department of Botany, University of Wisconsin-Madison, Madison, Wisconsin, USA.

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http://dx.doi.org/10.1038/nchembio.1693DOI Listing
January 2015

Development of next-generation macromolecular drugs based on the EPR effect: challenges and pitfalls.

Expert Opin Drug Deliv 2015 Jan 26;12(1):53-64. Epub 2014 Nov 26.

Sojo University, Institute for Drug Delivery Science , Ikeda 4-22-1, Nishi-ku, Kumamoto, 860-0082 , Japan

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http://dx.doi.org/10.1517/17425247.2014.955011DOI Listing
January 2015

Effect of different chemical bonds in pegylation of zinc protoporphyrin that affects drug release, intracellular uptake, and therapeutic effect in the tumor.

Eur J Pharm Biopharm 2015 Jan 16;89:259-70. Epub 2014 Dec 16.

Institute for Drug Delivery Science, Sojo University, Kumamoto, Japan. Electronic address:

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January 2015

Gingival overgrowth caused by vitamin C deficiency associated with metabolic syndrome and severe periodontal infection: a case report.

Clin Case Rep 2014 Dec 4;2(6):286-95. Epub 2014 Sep 4.

Department of Pathophysiology-Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences 2-5-1 Shikata-cho Kita-ku, Okayama, 700-8525, Japan.

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http://doi.wiley.com/10.1002/ccr3.114
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270712PMC
December 2014

Enhanced bacterial tumor delivery by modulating the EPR effect and therapeutic potential of Lactobacillus casei.

J Pharm Sci 2014 Oct 16;103(10):3235-43. Epub 2014 Jul 16.

Institute of Drug Delivery Science, Sojo University, Ikeda 4-22-1, Kumamoto, 860-0082, Japan; Laboratory of Microbiology and Oncology, Faculty of Pharmaceutical Sciences, Sojo University, Ikeda 4-22-1, Kumamoto, 860-0082, Japan.

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http://dx.doi.org/10.1002/jps.24083DOI Listing
October 2014

Synthetic (+)-terrein suppresses interleukin-6/soluble interleukin-6 receptor induced-secretion of vascular endothelial growth factor in human gingival fibroblasts.

Bioorg Med Chem 2014 Oct 7;22(19):5338-44. Epub 2014 Aug 7.

Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University, 3-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan; Research Center of New Functional Materials for Energy Production, Storage and Transport, Okayama University, 3-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan; Japan Science and Technology Agency, ACT-C, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2014.07.047DOI Listing
October 2014

Styrene-maleic acid copolymer-encapsulated CORM2, a water-soluble carbon monoxide (CO) donor with a constant CO-releasing property, exhibits therapeutic potential for inflammatory bowel disease.

J Control Release 2014 Aug 20;187:14-21. Epub 2014 May 20.

DDS Research Institute, Sojo University, Ikeda 4-22-1, Nishi-ku, Kumamoto 860-0082, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2014.05.018DOI Listing
August 2014

Tuning of poly-S-nitrosated human serum albumin as superior antitumor nanomedicine.

J Pharm Sci 2014 Jul 20;103(7):2184-2188. Epub 2014 May 20.

Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, Japan; Center for Clinical Pharmaceutical Science, Kumamoto University, Kumamoto 862-0973, Japan. Electronic address:

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July 2014

Distribution of oral mucosal bacteria with mecA in patients undergoing hematopoietic cell transplantation.

Support Care Cancer 2014 Jun 19;22(6):1679-83. Epub 2014 Feb 19.

Department of Pathophysiology-Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

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http://link.springer.com/10.1007/s00520-014-2151-1
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June 2014

Upregulation of heme oxygenase-1 in colorectal cancer patients with increased circulation carbon monoxide levels, potentially affects chemotherapeutic sensitivity.

BMC Cancer 2014 Jun 14;14:436. Epub 2014 Jun 14.

Department of General Surgery, Sheng Jing Hospital, China Medical University, Shenyang City, Liaoning Province 110004, P, R, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075569PMC
June 2014

Research spotlight: emergence of EPR effect theory and development of clinical applications for cancer therapy.

Authors:
Hiroshi Maeda

Ther Deliv 2014 Jun;5(6):627-30

Institute of Drug Delivery Science, Sojo University, Kumamoto, Japan.

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http://dx.doi.org/10.4155/tde.14.36DOI Listing
June 2014

Role of callose synthases in transfer cell wall development in tocopherol deficient Arabidopsis mutants.

Front Plant Sci 2014 19;5:46. Epub 2014 Feb 19.

Department of Biochemistry and Molecular Biology, Michigan State University East Lansing, MI, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928550PMC
March 2014

Cytokine expression in human dermal fibroblasts stimulated with eosinophil cationic protein measured by protein array.

Asian Pac J Allergy Immunol 2013 Dec;31(4):271-6

Department of Pathophysiology-Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

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http://dx.doi.org/10.12932/AP0287.31.4.2013DOI Listing
December 2013