Dr. Hiroshi Kubo, MD, PhD - Johnson & Johnson - Chief Medical Officer

Dr. Hiroshi Kubo

MD, PhD

Johnson & Johnson

Chief Medical Officer

Chiyoda-ku, Tokyo | Japan

Main Specialties: Pulmonary Disease, Thoracic Surgery-Integrated

Additional Specialties: Respiratory diseases

ORCID logohttps://orcid.org/0000-0001-6097-4542

Dr. Hiroshi Kubo, MD, PhD - Johnson & Johnson - Chief Medical Officer

Dr. Hiroshi Kubo

MD, PhD

Introduction

Primary Affiliation: Johnson & Johnson - Chiyoda-ku, Tokyo , Japan

Specialties:

Additional Specialties:


View Dr. Hiroshi Kubo’s Resume / CV

Education

Apr 1988 - Mar 1992
Tohoku University Graduate School of Medicine
Ph.D.
Apr 1982 - Mar 1988
Tohoku University School of Medicine
M.D.

Publications

83Publications

1729Reads

1Profile Views

722PubMed Central Citations

Hospitalization costs and length of stay of Japanese children with respiratory syncytial virus: A structural equation modeling approach.

Medicine (Baltimore) 2018 Jul;97(29):e11491

Health Economics, Janssen Pharmaceutical KK, Tokyo, Japan.

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http://dx.doi.org/10.1097/MD.0000000000011491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086555PMC
July 2018
3 Reads
1 Citation
5.723 Impact Factor

Histone deacetylase inhibitor restores surfactant protein-C expression in alveolar-epithelial type II cells and attenuates bleomycin-induced pulmonary fibrosis in vivo.

Exp Lung Res 2015 7;41(8):422-34. Epub 2015 Jul 7.

a Department of Advanced Preventive Medicine for Infectious Disease , Tohoku University Graduate School of Medicine , 2-1 Seiryoumachi, Aobaku , Sendai , Japan.

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http://dx.doi.org/10.3109/01902148.2015.1060275DOI Listing
June 2016
36 Reads
7 Citations
1.754 Impact Factor

Isolation of individual cellular components from lung tissues of patients with lymphangioleiomyomatosis.

Am J Physiol Lung Cell Mol Physiol 2016 05 25;310(10):L899-908. Epub 2016 Mar 25.

Division of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, Tokyo, Japan;

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http://dx.doi.org/10.1152/ajplung.00365.2015DOI Listing
May 2016
39 Reads
1 Citation
4.080 Impact Factor

Novel Monoclonal Antibody LpMab-17 Developed by CasMab Technology Distinguishes Human Podoplanin from Monkey Podoplanin.

Monoclon Antib Immunodiagn Immunother 2016 Apr 3;35(2):109-16. Epub 2016 Mar 3.

1 Department of Regional Innovation, Tohoku University Graduate School of Medicine , Sendai, Japan .

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http://dx.doi.org/10.1089/mab.2015.0077DOI Listing
April 2016
63 Reads
7 Citations

Receptor for advanced glycation end products expressed on alveolar epithelial cells is the main target for hyperoxia-induced lung injury.

Respir Investig 2016 Mar 17;54(2):98-108. Epub 2015 Oct 17.

Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, Sendai, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.resinv.2015.08.009DOI Listing
March 2016
33 Reads

The non-antibiotic macrolide EM900 inhibits rhinovirus infection and cytokine production in human airway epithelial cells.

Physiol Rep 2015 Oct;3(10)

Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, Sendai, Japan

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http://dx.doi.org/10.14814/phy2.12557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632947PMC
October 2015
31 Reads
2 Citations

The effects of neuraminidase inhibitors on the release of oseltamivir-sensitive and oseltamivir-resistant influenza viruses from primary cultures of human tracheal epithelium.

J Med Virol 2015 Jan 16;87(1):25-34. Epub 2014 May 16.

Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, Sendai, Japan.

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http://dx.doi.org/10.1002/jmv.23974DOI Listing
January 2015
11 Reads
1 Citation
2.350 Impact Factor

Pulmonary administration of Am80 regenerates collapsed alveoli.

J Control Release 2014 Dec 13;196:154-60. Epub 2014 Oct 13.

Department of Pharmaceutics and Drug Delivery, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, 278-8510, Japan; Center for Physical Pharmaceutics, Research Institute for Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, 278-8510, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2014.10.004DOI Listing
December 2014
52 Reads
7.705 Impact Factor

Magnitude of influenza virus replication and cell damage is associated with interleukin-6 production in primary cultures of human tracheal epithelium.

Respir Physiol Neurobiol 2014 Oct 23;202:16-23. Epub 2014 Jul 23.

Virus Research Center, Clinical Research Division, Sendai National Hospital, Sendai 983-8520, Japan.

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http://dx.doi.org/10.1016/j.resp.2014.07.010DOI Listing
October 2014
17 Reads
4 Citations
1.971 Impact Factor

Cyclin-dependent kinase-specific activity predicts the prognosis of stage I and stage II non-small cell lung cancer.

BMC Cancer 2014 Oct 9;14:755. Epub 2014 Oct 9.

Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, 2-1 Seiryoumachi, Aobaku, Sendai 980-8575, Japan.

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http://dx.doi.org/10.1186/1471-2407-14-755DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198674PMC
October 2014
33 Reads
1 Citation
3.362 Impact Factor

Additional treatment with clarithromycin reduces fever duration in patients with influenza.

Respir Investig 2014 Sep 11;52(5):302-9. Epub 2014 Jul 11.

Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.resinv.2014.05.001DOI Listing
September 2014
8 Reads
2 Citations

The role of microparticles in chronic obstructive pulmonary disease.

Int J Chron Obstruct Pulmon Dis 2014 27;9:303-14. Epub 2014 Mar 27.

Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, Sendai, Japan.

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http://dx.doi.org/10.2147/COPD.S38931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3971913PMC
August 2014
5 Reads
13 Citations
2.732 Impact Factor

Pulmonary administration of integrin-nanoparticles regenerates collapsed alveoli.

J Control Release 2014 Aug 2;187:167-74. Epub 2014 Jun 2.

Department of Pharmaceutics and Drug Delivery, Faculty of Pharmaceutical Science, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan; Center for Physical Pharmaceutics, Research Institute for Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2014.05.050DOI Listing
August 2014
8 Reads
3 Citations
7.705 Impact Factor

Formoterol and budesonide inhibit rhinovirus infection and cytokine production in primary cultures of human tracheal epithelial cells.

Respir Investig 2014 Jul 6;52(4):251-60. Epub 2014 May 6.

Medicine and Science in Sports and Exercise, Tohoku University Graduate School of Medicine, Sendai, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.resinv.2014.03.004DOI Listing
July 2014
24 Reads
4 Citations

Ubiquinol-10 supplementation activates mitochondria functions to decelerate senescence in senescence-accelerated mice.

Antioxid Redox Signal 2014 Jun 14;20(16):2606-20. Epub 2013 Dec 14.

1 Department of Aging Biology, Institute of Pathogenesis and Disease Prevention, Shinshu University Graduate School of Medicine , Matsumoto, Japan .

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http://dx.doi.org/10.1089/ars.2013.5406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4025630PMC
June 2014
25 Reads
9 Citations
7.410 Impact Factor

c-Kit immunoexpression delineates a putative endothelial progenitor cell population in developing human lungs.

Am J Physiol Lung Cell Mol Physiol 2014 May 28;306(9):L855-65. Epub 2014 Feb 28.

Dept. of Advanced Preventive Medicine for Infectious Disease, Tohoku Univ. School of Medicine, 2-1 Seiryoumachi, Aobaku, Sendai 980-8575, Japan.

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http://dx.doi.org/10.1152/ajplung.00211.2013DOI Listing
May 2014
3 Reads
6 Citations
4.080 Impact Factor

Ambroxol inhibits rhinovirus infection in primary cultures of human tracheal epithelial cells.

Arch Pharm Res 2014 Apr 16;37(4):520-9. Epub 2013 Jul 16.

Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan,

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http://dx.doi.org/10.1007/s12272-013-0210-7DOI Listing
April 2014
34 Reads
4 Citations
1.751 Impact Factor

Annual FEV1 changes and numbers of circulating endothelial microparticles in patients with COPD: a prospective study.

BMJ Open 2014 Mar 6;4(3):e004571. Epub 2014 Mar 6.

Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, Sendai, Japan.

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http://dx.doi.org/10.1136/bmjopen-2013-004571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948576PMC
March 2014
15 Reads
6 Citations
2.063 Impact Factor

Differences in the released endothelial microparticle subtypes between human pulmonary microvascular endothelial cells and aortic endothelial cells in vitro.

Exp Lung Res 2013 May-Jun;39(4-5):155-61. Epub 2013 Apr 3.

Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, Sendai, Japan.

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http://dx.doi.org/10.3109/01902148.2013.784932DOI Listing
December 2013
17 Reads
11 Citations
1.754 Impact Factor

Addition of oral cavity brushing and rehabilitation reduces fever in tube-fed patients.

Geriatr Gerontol Int 2013 Oct;13(4):1082-4

National Hospital Organization, Hachinohe National Hospital, Hachinohe, Japan.

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http://dx.doi.org/10.1111/ggi.12088DOI Listing
October 2013
12 Reads

The increase of microRNA-21 during lung fibrosis and its contribution to epithelial-mesenchymal transition in pulmonary epithelial cells.

Respir Res 2013 Sep 24;14:95. Epub 2013 Sep 24.

Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, 2-1 Seiryoumachi, Aobaku 980-8575, Sendai, Japan.

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http://dx.doi.org/10.1186/1465-9921-14-95DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849377PMC
September 2013
15 Reads
18 Citations

Tulobuterol inhibits rhinovirus infection in primary cultures of human tracheal epithelial cells.

Physiol Rep 2013 Aug 22;1(3):e00041. Epub 2013 Aug 22.

Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine Sendai, Japan.

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http://dx.doi.org/10.1002/phy2.41DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834998PMC
August 2013
16 Reads
3 Citations

Total synthesis and biological evaluation of (-)-exiguolide analogues: importance of the macrocyclic backbone.

Org Biomol Chem 2013 Jun 28;11(21):3442-50. Epub 2013 Mar 28.

Graduate School of Life Sciences, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577, Japan.

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http://dx.doi.org/10.1039/c3ob40131fDOI Listing
June 2013
31 Reads
1 Citation
3.562 Impact Factor

A placebo-controlled randomized trial of warfarin in idiopathic pulmonary fibrosis: a hidden subgroup?

Am J Respir Crit Care Med 2013 May;187(9):1029-30

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http://dx.doi.org/10.1164/rccm.201210-1782LEDOI Listing
May 2013
28 Reads
13.000 Impact Factor

Increased circulating endothelial microparticles in COPD patients: a potential biomarker for COPD exacerbation susceptibility.

Thorax 2012 Dec 27;67(12):1067-74. Epub 2012 Jul 27.

Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, 2-1 Seiryoumachi, Aobaku, Sendai 980-8575, Japan.

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http://dx.doi.org/10.1136/thoraxjnl-2011-201395DOI Listing
December 2012
35 Reads
29 Citations
8.290 Impact Factor

Gene expression profiles of alveolar type II cells of chronic obstructive pulmonary disease: a case-control study.

BMJ Open 2012 31;2(6). Epub 2012 Oct 31.

Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, Sendai, Japan.

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http://dx.doi.org/10.1136/bmjopen-2012-001553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3532994PMC
November 2012
7 Reads
5 Citations
2.063 Impact Factor

Analysis of gene expression profiles in alveolar epithelial type II-like cells differentiated from human alveolar epithelial progenitor cells.

Respir Investig 2012 Sep 23;50(3):110-6. Epub 2012 Aug 23.

Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, 2-1 Seiryoumachi, Aobaku, Sendai 980-8575, Japan.

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http://dx.doi.org/10.1016/j.resinv.2012.07.002DOI Listing
September 2012
8 Reads
4 Citations

Levofloxacin inhibits rhinovirus infection in primary cultures of human tracheal epithelial cells.

Antimicrob Agents Chemother 2012 Aug 14;56(8):4052-61. Epub 2012 May 14.

Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, Sendai, Japan.

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http://dx.doi.org/10.1128/AAC.00259-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3421613PMC
August 2012
27 Reads
3 Citations
4.480 Impact Factor

Concise review: clinical prospects for treating chronic obstructive pulmonary disease with regenerative approaches.

Authors:
Hiroshi Kubo

Stem Cells Transl Med 2012 Aug 24;1(8):627-31. Epub 2012 Jul 24.

Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, Sendai, Japan.

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http://dx.doi.org/10.5966/sctm.2012-0065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659729PMC
August 2012
15 Reads
4 Citations
3.600 Impact Factor

Inhibitory effects of tiotropium on rhinovirus infection in human airway epithelial cells.

Eur Respir J 2012 Jul 23;40(1):122-32. Epub 2012 Feb 23.

Dept of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan.

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http://dx.doi.org/10.1183/09031936.00065111DOI Listing
July 2012
32 Reads
7 Citations
7.640 Impact Factor

A novel method for isolating individual cellular components from the adult human distal lung.

Am J Respir Cell Mol Biol 2012 Apr 27;46(4):422-30. Epub 2011 Oct 27.

Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, Aobaku, Sendai, Japan.

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http://dx.doi.org/10.1165/rcmb.2011-0172OCDOI Listing
April 2012
7 Reads
26 Citations
3.985 Impact Factor

Tissue engineering for pulmonary diseases: insights from the laboratory.

Authors:
Hiroshi Kubo

Respirology 2012 Apr;17(3):445-54

Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, Sendai, Japan.

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http://dx.doi.org/10.1111/j.1440-1843.2012.02145.xDOI Listing
April 2012
32 Reads
4 Citations
3.500 Impact Factor

Administration of a specific inhibitor of neutrophil elastase attenuates pulmonary fibrosis after acute lung injury in mice.

Exp Lung Res 2012 Feb 8;38(1):28-36. Epub 2011 Dec 8.

Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, Sendai, Japan.

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http://dx.doi.org/10.3109/01902148.2011.633306DOI Listing
February 2012
15 Reads
8 Citations
1.754 Impact Factor

Early outcomes of chordal reconstruction for posterior mitral leaflet prolapse.

Asian Cardiovasc Thorac Ann 2012 Feb;20(1):24-9

Department of Cardiovascular Surgery, Kawasaki Medical School, Kurashiki, Japan.

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http://dx.doi.org/10.1177/0218492311433774DOI Listing
February 2012
28 Reads
1 Citation

l-carbocisteine inhibits respiratory syncytial virus infection in human tracheal epithelial cells.

Respir Physiol Neurobiol 2012 Jan 7;180(1):112-8. Epub 2011 Nov 7.

Department of Infectious Disease, Sendai City Hospital, Sendai, Japan.

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http://dx.doi.org/10.1016/j.resp.2011.10.017DOI Listing
January 2012
55 Reads
4 Citations
1.971 Impact Factor

[Regenerative approach for COPD].

Authors:
Hiroshi Kubo

Nihon Rinsho 2011 Oct;69(10):1869-72

Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine.

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October 2011
6 Reads

Evidence for human lung stem cells.

N Engl J Med 2011 08;365(5):465; author reply 465-6

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http://dx.doi.org/10.1056/NEJMc1106693DOI Listing
August 2011
6 Reads
1 Citation
55.873 Impact Factor

[Acute lung injury/acute respiratory distress syndrome: progress in diagnosis and treatment. Topics: IV. Recent topics: 3. Cell therapy for ARDS].

Authors:
Hiroshi Kubo

Nihon Naika Gakkai Zasshi 2011 Jun;100(6):1613-8

Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, Japan.

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http://dx.doi.org/10.2169/naika.100.1613DOI Listing
June 2011
11 Reads

Impaired endothelial progenitor cell mobilization and colony-forming capacity in chronic obstructive pulmonary disease.

Respirology 2011 May;16(4):680-7

Department of Anesthesiology, Tohoku University Hospital Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, Sendai Division of Thoracic Surgery, Japanese Red-Cross Ishinomaki Hospital, Ishinomaki, Japan.

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http://dx.doi.org/10.1111/j.1440-1843.2011.01959.xDOI Listing
May 2011
5 Reads
14 Citations
3.500 Impact Factor

Molecular basis of lung tissue regeneration.

Authors:
Hiroshi Kubo

Gen Thorac Cardiovasc Surg 2011 Apr 12;59(4):231-44. Epub 2011 Apr 12.

Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, 2-1 Seiryoumachi, Aobaku, Sendai 980-8575, Japan.

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http://dx.doi.org/10.1007/s11748-010-0757-xDOI Listing
April 2011
7 Reads
5 Citations

Receptor for advanced glycation end products binds to phosphatidylserine and assists in the clearance of apoptotic cells.

EMBO Rep 2011 Apr 11;12(4):358-64. Epub 2011 Mar 11.

Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan.

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http://dx.doi.org/10.1038/embor.2011.28DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077249PMC
April 2011
46 Reads
52 Citations
9.055 Impact Factor

Isolation of alveolar epithelial type II progenitor cells from adult human lungs.

Lab Invest 2011 Mar 15;91(3):363-78. Epub 2010 Nov 15.

Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, Aobaku, Sendai, Japan.

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http://dx.doi.org/10.1038/labinvest.2010.187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125101PMC
March 2011
39 Reads
26 Citations
3.680 Impact Factor

Inducible disruption of autophagy in the lung causes airway hyper-responsiveness.

Biochem Biophys Res Commun 2011 Feb 23;405(1):13-8. Epub 2010 Dec 23.

Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2010.12.092DOI Listing
February 2011
44 Reads
10 Citations
2.300 Impact Factor

Total synthesis and biological assessment of (-)-exiguolide and analogues.

Chemistry 2011 Feb 24;17(9):2678-88. Epub 2011 Jan 24.

Graduate School of Life Sciences, Tohoku University, Aoba-ku, Sendai, Japan.

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http://dx.doi.org/10.1002/chem.201003135DOI Listing
February 2011
5 Reads
5 Citations
5.731 Impact Factor

Procaterol inhibits rhinovirus infection in primary cultures of human tracheal epithelial cells.

Eur J Pharmacol 2011 Jan 15;650(1):431-44. Epub 2010 Oct 15.

Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, Japan.

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http://dx.doi.org/10.1016/j.ejphar.2010.09.056DOI Listing
January 2011
11 Reads
7 Citations
2.532 Impact Factor

Inhibitory effects of carbocisteine on type A seasonal influenza virus infection in human airway epithelial cells.

Am J Physiol Lung Cell Mol Physiol 2010 Aug 11;299(2):L160-8. Epub 2010 Jun 11.

Dept. of Advanced Preventive Medicine for Infectious Disease, Tohoku Univ. School of Medicine, Seiryo-machi, Aoba-ku, Sendai, Japan.

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http://dx.doi.org/10.1152/ajplung.00376.2009DOI Listing
August 2010
31 Reads
5 Citations
4.080 Impact Factor

[Lung tissue stem cells].

Authors:
Hiroshi Kubo

Arerugi 2010 Jun;59(6):667-70

Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine.

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June 2010
29 Reads

Clarithromycin inhibits type a seasonal influenza virus infection in human airway epithelial cells.

J Pharmacol Exp Ther 2010 Apr 29;333(1):81-90. Epub 2009 Dec 29.

Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University School of Medicine, 2-1 Seiryo-machi, Aoba-ku 980-8575, Japan.

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http://jpet.aspetjournals.org/content/333/1/81.full.pdf
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http://jpet.aspetjournals.org/content/early/2009/12/29/jpet.
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http://jpet.aspetjournals.org/cgi/doi/10.1124/jpet.109.16214
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http://dx.doi.org/10.1124/jpet.109.162149DOI Listing
April 2010
43 Reads
16 Citations
3.972 Impact Factor

Isolation and characterization of murine multipotent lung stem cells.

Stem Cells Dev 2010 Apr;19(4):523-36

Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University School of Medicine, Sendai, Japan.

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http://dx.doi.org/10.1089/scd.2009.0287DOI Listing
April 2010
6 Reads
21 Citations
3.730 Impact Factor

Impairment of swallowing in COPD.

Am J Respir Crit Care Med 2009 Sep;180(5):481; author reply 481

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http://dx.doi.org/10.1164/ajrccm.180.5.481DOI Listing
September 2009
18 Reads
1 Citation
13.000 Impact Factor

Carbocisteine inhibits oxidant-induced apoptosis in cultured human airway epithelial cells.

Respirology 2009 Sep 2;14(7):1027-34. Epub 2009 Aug 2.

Department of Geriatrics, Tohoku University School of Medicine, Sendai, Japan.

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http://dx.doi.org/10.1111/j.1440-1843.2009.01594.xDOI Listing
September 2009
21 Reads
3 Citations
3.500 Impact Factor

Seizure and pneumonia in an elderly patient with systemic lupus erythematosus.

J Am Geriatr Soc 2009 Sep;57(9):1709-11

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http://dx.doi.org/10.1111/j.1532-5415.2009.02386.xDOI Listing
September 2009
27 Reads
1 Citation
4.572 Impact Factor

Macrolide antibiotics inhibit respiratory syncytial virus infection in human airway epithelial cells.

Antiviral Res 2009 Aug 20;83(2):191-200. Epub 2009 May 20.

Department of Geriatrics and Gerontology, Tohoku University School of Medicine, Sendai, Japan.

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http://dx.doi.org/10.1016/j.antiviral.2009.05.003DOI Listing
August 2009
47 Reads
13 Citations
3.940 Impact Factor

L-carbocisteine reduces neutrophil elastase-induced mucin production.

Respir Physiol Neurobiol 2009 Jun 24;167(2):214-6. Epub 2009 Apr 24.

First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, 390-8621, Japan.

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http://dx.doi.org/10.1016/j.resp.2009.04.016DOI Listing
June 2009
35 Reads
1 Citation
1.971 Impact Factor

Identification of mesenchymal stem cell (MSC)-transcription factors by microarray and knockdown analyses, and signature molecule-marked MSC in bone marrow by immunohistochemistry.

Genes Cells 2009 Mar 17;14(3):407-24. Epub 2009 Feb 17.

Department of Dental and Medical Biochemistry, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.

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http://dx.doi.org/10.1111/j.1365-2443.2009.01281.xDOI Listing
March 2009
13 Reads
32 Citations
2.810 Impact Factor

Intranasal HGF administration ameliorates the physiologic and morphologic changes in lung emphysema.

Mol Ther 2008 Aug 17;16(8):1417-26. Epub 2008 Jun 17.

Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Aobaku, Sendai, Japan.

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http://dx.doi.org/10.1038/mt.2008.137DOI Listing
August 2008
4 Reads
20 Citations
6.230 Impact Factor

Submucosal gland cells in human lower airways produce MUC5AC protein.

Respirology 2008 Mar;13(2):285-7

Department of Geriatrics and Gerontology, Tohoku University Hospital, Seiryoumachi, Sendai 980-8574, Japan.

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http://dx.doi.org/10.1111/j.1440-1843.2007.01195.xDOI Listing
March 2008
3 Reads
1 Citation
3.500 Impact Factor

Erythromycin attenuates MUC5AC synthesis and secretion in cultured human tracheal cells infected with RV14.

Respirology 2008 Mar;13(2):215-20

Department of Geriatrics and Gerontology, Tohoku University Hospital, Sendai, Japan.

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http://dx.doi.org/10.1111/j.1440-1843.2007.01227.xDOI Listing
March 2008
5 Reads
2 Citations
3.500 Impact Factor

The role of the receptor for advanced glycation end-products in lung fibrosis.

Am J Physiol Lung Cell Mol Physiol 2007 Dec 19;293(6):L1427-36. Epub 2007 Oct 19.

Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Sendai, Japan.

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http://dx.doi.org/10.1152/ajplung.00075.2007DOI Listing
December 2007
10 Reads
51 Citations
4.080 Impact Factor

Impairment of the swallowing reflex in exacerbations of COPD.

Thorax 2007 Nov;62(11):1017

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http://dx.doi.org/10.1136/thx.2007.084715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2117129PMC
November 2007
8 Reads
5 Citations
8.290 Impact Factor

[Cell based therapy for COPD].

Authors:
Hiroshi Kubo

Nihon Rinsho 2007 Apr;65(4):740-7

Department of Geriatrics and Gerontology, Tohoku University Hospital.

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April 2007
2 Reads

Study on safety and bioavailability of ubiquinol (Kaneka QH) after single and 4-week multiple oral administration to healthy volunteers.

Regul Toxicol Pharmacol 2007 Feb 21;47(1):19-28. Epub 2006 Aug 21.

Pharmacology and Toxicology Group, Life Science Research Laboratories, Kaneka Corporation, 1-8 Miyamae-Machi, Takasago-Shi, Hyogo, Japan.

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http://dx.doi.org/10.1016/j.yrtph.2006.07.001DOI Listing
February 2007
18 Reads
11 Citations
2.031 Impact Factor

[Possibility of alveolar regeneration].

Nihon Ronen Igakkai Zasshi 2007 Jan;44(1):79-82

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http://dx.doi.org/10.3143/geriatrics.44.79DOI Listing
January 2007
3 Reads

Endogenous secretory receptor for advanced glycation end products in non-small cell lung carcinoma.

Am J Respir Crit Care Med 2007 Jan 5;175(2):184-9. Epub 2006 Oct 5.

Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, 1-1 Seiryoumachi, Aobaku, Sendai, Japan.

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http://dx.doi.org/10.1164/rccm.200602-212OCDOI Listing
January 2007
10 Reads
6 Citations
13.000 Impact Factor

Interleukin-1beta gene polymorphisms associated with risk of lung cancer in Japanese.

Lung Cancer 2006 Nov 1;54(2):261-3. Epub 2006 Sep 1.

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http://dx.doi.org/10.1016/j.lungcan.2006.07.002DOI Listing
November 2006
7 Reads
6 Citations
3.960 Impact Factor

IL-17A promotes the growth of airway epithelial cells through ERK-dependent signaling pathway.

Biochem Biophys Res Commun 2006 Sep 30;347(4):852-8. Epub 2006 Jun 30.

Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2006.06.137DOI Listing
September 2006
5 Reads
15 Citations
2.300 Impact Factor

Dysphagia in a patient with rapidly enlarged thoracic aortic aneurysm.

J Am Geriatr Soc 2006 Aug;54(8):1294

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http://dx.doi.org/10.1111/j.1532-5415.2006.00816.xDOI Listing
August 2006
3 Reads
4.572 Impact Factor

Comment on "Cutting edge: TLR4 deficiency confers susceptibility to lethal oxidant lung injury".

J Immunol 2006 Apr;176(7):3856-7; author reply 3857

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http://dx.doi.org/10.4049/jimmunol.176.7.3856-aDOI Listing
April 2006
8 Reads
4.922 Impact Factor