Publications

Gene expression analysis of hypersensitivity to mosquito bite, chronic active EBV infection and NK/T-lymphoma/leukemia.
Leuk Lymphoma 2017 Nov 3;58(11):2683-2694. Epub 2017 Apr 3.
a Department of Pediatrics , Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , Okayama , Japan.

Essential roles of G9a in cell proliferation and differentiation during tooth development.
Exp Cell Res 2017 Aug 17;357(2):202-210. Epub 2017 May 17.
Department of Pharmacology, School of Dental Medicine, Tsurumi University, 2-1-3 Tsurumi, Tsurumi-ku, Yokohama 230-8501, Japan. Electronic address:

The effects of arousal accompanying an apneic event on blood pressure and sympathetic nerve activity in severe obstructive sleep apnea.
Sleep Breath 2017 Aug 7. Epub 2017 Aug 7.
Department of Advanced Medicine for Pulmonary Circulation and Respiratory Failure, and Department of Pulmonary Medicine, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.



Efficacy of clozapine on dopamine supersensitivity psychosis in schizophrenia.
Int Clin Psychopharmacol 2017 May;32(3):169-173
aDepartment of Psychiatry, Graduate School of Medicine bDivision of Medical Treatment and Rehabilitation, Center for Forensic Mental Health, Chiba University, Chiba, Japan cClinic for Psychiatry and Psychotherapy, Ludwig Maximilians University of Munich, Munich, Germany.

Crystal Structure and Characterization of Novel Human Histone H3 Variants, H3.6, H3.7, and H3.8.
Biochemistry 2017 Apr 10;56(16):2184-2196. Epub 2017 Apr 10.
Laboratory of Structural Biology, Graduate School of Advanced Science and Engineering, Research Institute for Science and Engineering, and Institute for Medical-oriented Structural Biology, Waseda University , 2-2 Wakamatsu-cho, Shinjuku-ku, Tokyo 162-8480, Japan.

Xeroderma pigmentosum group C protein interacts with histones: regulation by acetylated states of histone H3.
Genes Cells 2017 Mar 24;22(3):310-327. Epub 2017 Feb 24.
Division of Genomic Functions and Dynamics, Biosignal Research Center, Kobe University, 1-1 Rokkodai-cho, Nada-ku, Kobe, Hyogo, 657-8501, Japan.

Global histone modification fingerprinting in human cells using epigenetic reverse phase protein array.
Cell Death Discov 2017 6;3:16077. Epub 2017 Mar 6.
Synthetic Epigenetics Laboratory, MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh , Edinburgh, UK.


ZnO-Based Microfluidic pH Sensor: A Versatile Approach for Quick Recognition of Circulating Tumor Cells in Blood.
ACS Appl Mater Interfaces 2017 Feb 3;9(6):5193-5203. Epub 2017 Feb 3.
Micro/Nano Technology Center, ‡Graduate School of Science and Technology, §Department of Mechanical Engineering, and ∥Department of Precision Engineering, Tokai University , 4-1-1 Kitakaname, Hiratsuka, Kanagawa 259-1292, Japan.

Differential lactate and cholesterol synthetic activities in XY and XX Sertoli cells.
Sci Rep 2017 Feb 2;7:41912. Epub 2017 Feb 2.
Division of Molecular Life Sciences, Graduate School of Systems Life Science, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan.

Testis-Specific Histone Variant H3t Gene Is Essential for Entry into Spermatogenesis.
Cell Rep 2017 Jan;18(3):593-600
Center for Genetic Analysis of Biological Responses, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita 565-0871, Japan; Faculty of Biology-Oriented Science and Technology, Kindai University, Kinokawa, Wakayama 649-6493, Japan. Electronic address:

Targeting the Notch-regulated non-coding RNA TUG1 for glioma treatment.
Nat Commun 2016 Dec 6;7:13616. Epub 2016 Dec 6.
Department of Epigenomics, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan.


A Genetically Encoded Probe for Live-Cell Imaging of H4K20 Monomethylation.
J Mol Biol 2016 Oct 14;428(20):3885-3902. Epub 2016 Aug 14.
Cell Biology Unit, Institute of Innovative Research, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan. Electronic address:

Efficacy of periodically rotated overlapping parallel lines with enhanced reconstruction (PROPELLER) for shoulder magnetic resonance (MR) imaging.
Eur J Radiol 2016 Oct 16;85(10):1735-1743. Epub 2016 Jul 16.
Department of Surgery, Kimura Hospital, 2-13-19 Chiyo, Hakata-ku, Fukuoka 812-0044, Japan. Electronic address:



HSV-2-related hemophagocytic lymphohistiocytosis in a fingolimod-treated patient with MS.
Neurol Neuroimmunol Neuroinflamm 2016 Aug 7;3(4):e247. Epub 2016 Jun 7.
Departments of Neurology (K.I., M.K., G.S.) and Virology (H. Kimura), and Center for Brain & Mind Research Promotion (G.S.), Nagoya University Graduate School of Medicine; Departments of Neurology (K.I., T.A.) and Pathology (Y.S.), Anjo Kosei Hospital; Department of Pathology (H. Katano), National Institute of Infectious Diseases, Tokyo; Department of Neuropathology (M.Y.), Institute of Medical Science of Aging, Aichi Medical University, Nagakute; and Department of Neurology (T.S.), Kyoto-Min-Iren-Central Hospital, Kyoto, Japan.

Genome-wide genetic screen identified the link between dG9a and epidermal growth factor receptor signaling pathway in vivo.
Exp Cell Res 2016 Aug 22;346(1):53-64. Epub 2016 Jun 22.
Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan; Insect Biomedical Research Center, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan. Electronic address:


Structure and function of human histone H3.Y nucleosome.
Nucleic Acids Res 2016 Jul 25;44(13):6127-41. Epub 2016 Mar 25.
Laboratory of Structural Biology, Graduate School of Advanced Science and Engineering, Waseda University, 2-2 Wakamatsu-cho, Shinjuku-ku, Tokyo 162-8480, Japan Research Institute for Science and Engineering, Waseda University, 2-2 Wakamatsu-cho, Shinjuku-ku, Tokyo 162-8480, Japan Institute for Medical-oriented Structural Biology, Waseda University, 2-2 Wakamatsu-cho, Shinjuku-ku, Tokyo 162-8480, Japan

KAT7/HBO1/MYST2 Regulates CENP-A Chromatin Assembly by Antagonizing Suv39h1-Mediated Centromere Inactivation.
Dev Cell 2016 Jun;37(5):413-27
Laboratory of Cell Engineering, Department of Frontier Research, Kazusa DNA Research Institute, 2-6-7 Kazusa-Kamatari, Kisarazu 292-0818, Japan. Electronic address:

Histone H3K36 trimethylation is essential for multiple silencing mechanisms in fission yeast.
Nucleic Acids Res 2016 May 20;44(9):4147-62. Epub 2016 Jan 20.
Graduate School of Chemical Sciences and Engineering, Hokkaido University, Sapporo 060-0810, Japan Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo 060-0810, Japan

In vivo tracking of histone H3 lysine 9 acetylation in Xenopus laevis during tail regeneration.
Genes Cells 2016 Apr 24;21(4):358-69. Epub 2016 Feb 24.
Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University, 1-3-1 Kagamiyama, Higashihiroshima, 739-8526, Hiroshima, Japan.


Effects of Lowering Dialysate Calcium Concentration on Mineral and Bone Disorders in Chronic Hemodialysis Patients: Conversion from 3.0 mEq/L to 2.75 mEq/L.
Ther Apher Dial 2016 Feb 20;20(1):31-9. Epub 2015 Oct 20.
Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Long-term ex vivo maintenance of testis tissues producing fertile sperm in a microfluidic device.
Sci Rep 2016 Feb 19;6:21472. Epub 2016 Feb 19.
Laboratory of Proteomics, Institute of Molecular Medicine and Life Science, Yokohama City University Association of Medical Science, Yokohama, Kanagawa 236-0004, Japan.


Histone H3.5 forms an unstable nucleosome and accumulates around transcription start sites in human testis.
Epigenetics Chromatin 2016 15;9. Epub 2016 Jan 15.
Laboratory of Structural Biology, Graduate School of Advanced Science and Engineering, Institute for Medical-oriented Structural Biology, Waseda University, 2-2 Wakamatsu-cho, Shinjuku-ku, Tokyo, 162-8480 Japan.

H3K4/H3K9me3 Bivalent Chromatin Domains Targeted by Lineage-Specific DNA Methylation Pauses Adipocyte Differentiation.
Mol Cell 2015 Nov;60(4):584-96
Division of Metabolic Medicine, The University of Tokyo, 4-6-1, Komaba, Meguro-ku, Tokyo 153-8904, Japan; The Translational Systems Biology and Medicine Initiative (TSBMI), Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, Tokyo 113-8655, Japan. Electronic address:

Decreased levels of serum oxytocin in pediatric patients with Attention Deficit/Hyperactivity Disorder.
Psychiatry Res 2015 Aug 15;228(3):746-51. Epub 2015 Jun 15.
Department of Child Psychiatry, Chiba University Hospital, Japan; Department of Psychiatry, Chiba University Graduate School of Medicine, Japan; Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Japan; Division of Medical Treatment and Rehabilitation, Chiba University Center for Forensic Mental Health, Japan.

STAT5 Orchestrates Local Epigenetic Changes for Chromatin Accessibility and Rearrangements by Direct Binding to the TCRγ Locus.
J Immunol 2015 Aug 20;195(4):1804-14. Epub 2015 Jul 20.
Laboratory of Biological Protection, Department of Biological Responses, Institute for Virus Research, Kyoto University, Kyoto 606-8507, Japan;

Highly condensed chromatins are formed adjacent to subtelomeric and decondensed silent chromatin in fission yeast.
Nat Commun 2015 Jul 24;6:7753. Epub 2015 Jul 24.
1] Advanced ICT Research Institute Kobe, National Institute of Information and Communications Technology, 588-2, Iwaoka, Iwaoka-cho, Kobe 651-2492, Japan [2] Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita 565-0871, Japan.

Histone H4 acetylation required for chromatin decompaction during DNA replication.
Sci Rep 2015 Jul 30;5:12720. Epub 2015 Jul 30.
1] Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita 565-0871, Japan [2] Advanced ICT Research Institute Kobe, National Institute of Information and Communications Technology, 588-2 Iwaoka, Iwaoka-cho, Nishi-ku, Kobe 651-2492, Japan.

A Herpesvirus Specific Motif of Epstein-Barr Virus DNA Polymerase Is Required for the Efficient Lytic Genome Synthesis.
Sci Rep 2015 Jun 30;5:11767. Epub 2015 Jun 30.
1] Division of Virology, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-ku, Nagoya 464-8681, Japan [2] Department of Virology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.

JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis.
Nat Commun 2015 May 7;6:7052. Epub 2015 May 7.
1] Division of Metabolic Medicine, Research Center for Advanced Science and Technology (RCAST), The University of Tokyo, Tokyo 153-8904, Japan [2] The Translational Systems Biology and Medicine Initiative, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, University of Tokyo, Tokyo 113-8655, Japan.

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