Publications by authors named "Hiroshi Asahara"

100Publications

The tRNA pseudouridine synthase TruB1 regulates the maturation of let-7 miRNA.

EMBO J 2020 Oct 14;39(20):e104708. Epub 2020 Sep 14.

Department of Systems BioMedicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.

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http://dx.doi.org/10.15252/embj.2020104708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7560213PMC
October 2020

Regulation of tendon and ligament differentiation.

Bone 2020 Aug 20:115609. Epub 2020 Aug 20.

Department of Molecular Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, MBB-102, , La Jolla, CA 92037, USA; Department of Systems Biomedicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bone.2020.115609DOI Listing
August 2020

pathway modulates the code via regulation during axial patterning in vertebrates.

Elife 2020 05 29;9. Epub 2020 May 29.

Department of Systems BioMedicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

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http://dx.doi.org/10.7554/eLife.53608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259951PMC
May 2020

Analysis of the Mouse Y Chromosome by Single-Molecule Sequencing With Y Chromosome Enrichment.

Front Genet 2020 7;11:406. Epub 2020 May 7.

Department of Systems BioMedicine, Tokyo Medical and Dental University, Tokyo, Japan.

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http://dx.doi.org/10.3389/fgene.2020.00406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221202PMC
May 2020

The transcription factors regulating intervertebral disc development.

JOR Spine 2020 Mar 20;3(1):e1081. Epub 2020 Feb 20.

Department of Molecular and Experimental Medicine The Scripps Research Institute La Jolla California.

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http://dx.doi.org/10.1002/jsp2.1081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084052PMC
March 2020

Tendon and ligament mechanical loading in the pathogenesis of inflammatory arthritis.

Nat Rev Rheumatol 2020 04 20;16(4):193-207. Epub 2020 Feb 20.

Molecular Immunology and Inflammation Unit, VIB Centre for Inflammation Research, Ghent University, Ghent, Belgium.

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http://dx.doi.org/10.1038/s41584-019-0364-xDOI Listing
April 2020

Post-transcriptional regulation of inflammation by RNA-binding proteins via cis-elements of mRNAs.

J Biochem 2019 Nov;166(5):375-382

Department of Systems BioMedicine, Tokyo Medical and Dental University, Tokyo, Japan.

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http://dx.doi.org/10.1093/jb/mvz067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804641PMC
November 2019

Wwp2 maintains cartilage homeostasis through regulation of Adamts5.

Nat Commun 2019 06 3;10(1):2429. Epub 2019 Jun 3.

Department of Molecular Medicine, The Scripps Research Institute, 10550 North Torrey Pines Rd., La Jolla, CA, 92037, USA.

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http://dx.doi.org/10.1038/s41467-019-10177-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546747PMC
June 2019

Zfp238 Regulates the Thermogenic Program in Cooperation with Foxo1.

iScience 2019 Feb 7;12:87-101. Epub 2019 Jan 7.

Navigation Medicine of Kidney and Metabolism, Division of Endocrinology, Metabolism, and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan.

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http://dx.doi.org/10.1016/j.isci.2019.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352565PMC
February 2019

Combinatorial CRISPR/Cas9 Approach to Elucidate a Far-Upstream Enhancer Complex for Tissue-Specific Sox9 Expression.

Dev Cell 2018 09 23;46(6):794-806.e6. Epub 2018 Aug 23.

Department of Systems BioMedicine, Tokyo Medical and Dental University, Tokyo 113-8510, Japan; Department of Molecular and Experimental Medicine, The Scripps Research Institute, San Diego, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2018.07.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324936PMC
September 2018

A tandem repeat array in IG-DMR is essential for imprinting of paternal allele at the Dlk1-Dio3 domain during embryonic development.

Hum Mol Genet 2018 09;27(18):3283-3292

Department of Systems BioMedicine, National Research Institute for Child Health and Development, Tokyo, Japan.

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http://dx.doi.org/10.1093/hmg/ddy235DOI Listing
September 2018

[Cartilage/chondrocyte research and osteoarthritis. Current topics and future of ligament regeneration therapy.]

Clin Calcium 2018;28(6):809-816

Department of Molecular Medicine, The Scripps Research Institute, USA/Department of Systems Biomedicine, Tokyo Medical and Dental University, Japan.

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http://dx.doi.org/CliCa1806809816DOI Listing
June 2019

Dissecting the roles of miR-140 and its host gene.

Nat Cell Biol 2018 05;20(5):516-518

Department of Systems BioMedicine, National Research Institute for Child Health and Development, Tokyo, Japan.

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http://dx.doi.org/10.1038/s41556-018-0077-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373877PMC
May 2018

Essential role of Mohawk for tenogenic tissue homeostasis including spinal disc and periodontal ligament.

Mod Rheumatol 2018 Nov 15;28(6):933-940. Epub 2018 May 15.

a Department of Systems Biomedicine , Tokyo Medical and Dental University , Tokyo , Japan.

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http://dx.doi.org/10.1080/14397595.2018.1466644DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511339PMC
November 2018

Bisulfite Sequencing for DNA Methylation Analysis of Primary Muscle Stem Cells.

Methods Mol Biol 2017 ;1668:3-13

Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA.

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http://dx.doi.org/10.1007/978-1-4939-7283-8_1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433475PMC
June 2018

Tendons and Ligaments: Connecting Developmental Biology to Musculoskeletal Disease Pathogenesis.

J Bone Miner Res 2017 Sep 13;32(9):1773-1782. Epub 2017 Jul 13.

Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.

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http://dx.doi.org/10.1002/jbmr.3199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585011PMC
September 2017

Identification of targets of tumor suppressor microRNA-34a using a reporter library system.

Proc Natl Acad Sci U S A 2017 04 29;114(15):3927-3932. Epub 2017 Mar 29.

Department of Systems BioMedicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Bunkyo, Tokyo 113-8519, Japan;

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http://dx.doi.org/10.1073/pnas.1620019114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5393199PMC
April 2017

E3 ubiquitin ligases SIAH1/2 regulate hypoxia-inducible factor-1 (HIF-1)-mediated Th17 cell differentiation.

Int Immunol 2017 03;29(3):133-143

Laboratory for Cytokine Regulation, RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama-shi, Kanagawa 230-0045, Japan.

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http://dx.doi.org/10.1093/intimm/dxx014DOI Listing
March 2017

Bhlha9 regulates apical ectodermal ridge formation during limb development.

J Bone Miner Metab 2018 Jan 21;36(1):64-72. Epub 2017 Mar 21.

Department of Systems BioMedicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.

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http://dx.doi.org/10.1007/s00774-017-0820-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324935PMC
January 2018

ARID2 modulates DNA damage response in human hepatocellular carcinoma cells.

J Hepatol 2017 05 24;66(5):942-951. Epub 2017 Feb 24.

Department of Molecular Oncology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan; Department of Hepato-Biliary-Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2016.12.026DOI Listing
May 2017

Secreted Metalloproteinase ADAMTS-3 Inactivates Reelin.

J Neurosci 2017 03 17;37(12):3181-3191. Epub 2017 Feb 17.

Department of Biomedical Science, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Aichi 467-8603, Japan,

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http://dx.doi.org/10.1523/JNEUROSCI.3632-16.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6596773PMC
March 2017

The transcription factor mohawk homeobox regulates homeostasis of the periodontal ligament.

Development 2017 01 19;144(2):313-320. Epub 2016 Dec 19.

Department of Systems BioMedicine, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan

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http://dx.doi.org/10.1242/dev.135798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394762PMC
January 2017

Deletion of conserved sequences in IG-DMR at Dlk1-Gtl2 locus suggests their involvement in expression of paternally expressed genes in mice.

J Reprod Dev 2017 Feb 1;63(1):101-109. Epub 2016 Dec 1.

Department of Systems BioMedicine, National Research Institute for Child Health and Development, Tokyo 157-8535, Japan.

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http://dx.doi.org/10.1262/jrd.2016-135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320436PMC
February 2017

Current Status and Strategy of microRNA Research for Cartilage Development and Osteoarthritis Pathogenesis.

Authors:
Hiroshi Asahara

J Bone Metab 2016 Aug 31;23(3):121-7. Epub 2016 Aug 31.

Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, USA.; Department of Systems BioMedicine, Tokyo Medical and Dental University, Tokyo, Japan.; The Core Research for the Evolutionary Science and Technology from Japan Agency for Medical Research and Development, Tokyo, Japan.

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http://dx.doi.org/10.11005/jbm.2016.23.3.121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018604PMC
August 2016

Dnmt3a Regulates Proliferation of Muscle Satellite Cells via p57Kip2.

PLoS Genet 2016 07 14;12(7):e1006167. Epub 2016 Jul 14.

Department of Systems BioMedicine, Tokyo Medical and Dental University, Bunkyo-Ku, Tokyo, Japan.

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http://dx.doi.org/10.1371/journal.pgen.1006167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944932PMC
July 2016

Gene targeting of the transcription factor Mohawk in rats causes heterotopic ossification of Achilles tendon via failed tenogenesis.

Proc Natl Acad Sci U S A 2016 07 1;113(28):7840-5. Epub 2016 Jul 1.

Department of Systems BioMedicine, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8510, Japan; Core Research for the Evolutionary Science and Technology, Japan Agency for Medical Research and Development, Chiyoda-ku, Tokyo 100-0004, Japan; Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037

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http://dx.doi.org/10.1073/pnas.1522054113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948356PMC
July 2016

Gtf2ird1-Dependent Mohawk Expression Regulates Mechanosensing Properties of the Tendon.

Mol Cell Biol 2016 Apr 31;36(8):1297-309. Epub 2016 Mar 31.

Department of Systems BioMedicine, Tokyo Medical and Dental University, Tokyo, Japan Department of Systems BioMedicine, National Institute of Child Health and Development, Tokyo, Japan Department of Molecular and Experimental Medicine, The Scripps Research Institute, San Diego, California, USA

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http://dx.doi.org/10.1128/MCB.00950-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836271PMC
April 2016

MicroRNA 140 Promotes Expression of Long Noncoding RNA NEAT1 in Adipogenesis.

Mol Cell Biol 2016 Jan 12;36(1):30-8. Epub 2015 Oct 12.

Department of Biochemistry and Molecular Biology, Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland, USA

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http://dx.doi.org/10.1128/MCB.00702-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702608PMC
January 2016

[Analysis of Musculoskeletal Systems and Their Diseases. The research for musculoskeletal disease using genome editing technology].

Clin Calcium 2015 Aug;25(8):1169-74

Department of Systems BioMedicine, Tokyo Medical and Dental University, Japan.

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http://dx.doi.org/CliCa150811691174DOI Listing
August 2015

TALEN-Mediated Gene Disruption on Y Chromosome Reveals Critical Role of EIF2S3Y in Mouse Spermatogenesis.

Stem Cells Dev 2015 May 25;24(10):1164-70. Epub 2015 Feb 25.

1 Department of Systems BioMedicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University , Tokyo, Japan .

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http://dx.doi.org/10.1089/scd.2014.0466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425228PMC
May 2015

Transcription factor Mohawk controls tenogenic differentiation of bone marrow mesenchymal stem cells in vitro and in vivo.

J Orthop Res 2015 Jan 13;33(1):1-8. Epub 2014 Oct 13.

Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, MEM-161, La Jolla, 92037, California; Department of System Biomedicine, National Research Institute for Child Health and Development, Tokyo, Japan; Center for Stem Cell and Regenerative Medicine, Tokyo Medical and Dental University, Tokyo, Japan.

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http://dx.doi.org/10.1002/jor.22750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294629PMC
January 2015

DNA methylation analysis of human myoblasts during in vitro myogenic differentiation: de novo methylation of promoters of muscle-related genes and its involvement in transcriptional down-regulation.

Hum Mol Genet 2015 Jan 4;24(2):410-23. Epub 2014 Sep 4.

Department of Systems BioMedicine and Department of Systems BioMedicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan and Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA

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https://academic.oup.com/hmg/article-lookup/doi/10.1093/hmg/
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http://dx.doi.org/10.1093/hmg/ddu457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275072PMC
January 2015

Contribution of transcription factor, SP1, to the promotion of HB-EGF expression in defense mechanism against the treatment of irinotecan in ovarian clear cell carcinoma.

Cancer Med 2014 Oct 24;3(5):1159-69. Epub 2014 Jul 24.

Department of Obstetrics and Gynecology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan; Department of Biochemistry, Faculty of Medicine, Fukuoka University, Fukuoka, Japan; Central Research Institute for Advanced Molecular Medicine, Fukuoka University, Fukuoka, Japan; Department of Systems BioMedicine, National Research Institute for Child Health and Development, Tokyo, Japan.

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http://dx.doi.org/10.1002/cam4.301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302667PMC
October 2014

Rapid generation of mouse models with defined point mutations by the CRISPR/Cas9 system.

Sci Rep 2014 Jun 23;4:5396. Epub 2014 Jun 23.

Department of Systems BioMedicine, National Research Institute for Child Health and Development, Tokyo 157-8535, Japan.

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http://dx.doi.org/10.1038/srep05396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066261PMC
June 2014

Transcription activator-like effector nuclease-mediated transduction of exogenous gene into IL2RG locus.

Sci Rep 2014 May 23;4:5043. Epub 2014 May 23.

1] Department of Systems BioMedicine, Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences, Tokyo 113-8510, Japan [2] Department of Systems BioMedicine, National Research Institute for Child Health and Development, Tokyo 157-8535, Japan [3] CREST, Japan Science and Technology Agency (JST), Saitama 332-0012, Japan [4] Department of Molecular and Experimental Medicine, The Scripps research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1038/srep05043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031469PMC
May 2014

The orally available Btk inhibitor ibrutinib (PCI-32765) protects against osteoclast-mediated bone loss.

Bone 2014 Mar 4;60:8-15. Epub 2013 Dec 4.

Department of Cell Signaling, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8549, Japan; Department of Immunology, Graduate School of Medicine, The University of Tokyo, Japan; Japan Science and Technology Agency (JST), Explorative Research for Advanced Technology (ERATO) Program, Takayanagi Osteonetwork Project, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bone.2013.11.025DOI Listing
March 2014

Production of Sry knockout mouse using TALEN via oocyte injection.

Sci Rep 2013 Nov 5;3:3136. Epub 2013 Nov 5.

1] Department of Systems BioMedicine, National Research Institute for Child Health and Development, Tokyo 157-8535, Japan [2].

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http://dx.doi.org/10.1038/srep03136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817445PMC
November 2013

The Mohawk homeobox transcription factor regulates the differentiation of tendons and volar plates.

J Orthop Sci 2014 Jan 29;19(1):172-80. Epub 2013 Oct 29.

Department of Systems BioMedicine, National Center for Child Health and Development, 2-10-1 Okura, Setagaya, Tokyo, 157-0074, Japan,

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http://dx.doi.org/10.1007/s00776-013-0485-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943675PMC
January 2014

Targeted gene deletion of miRNAs in mice by TALEN system.

PLoS One 2013 16;8(10):e76004. Epub 2013 Oct 16.

Department of Systems BioMedicine, National Research Institute for Child Health and Development, Tokyo, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0076004PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797721PMC
July 2014

Analysis of microRNAs expressions in chondrosarcoma.

J Orthop Res 2013 Dec 12;31(12):1992-8. Epub 2013 Aug 12.

Department of Systems Biomedicine, National Research Institute for Child Health and Development, Tokyo, Japan.

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http://dx.doi.org/10.1002/jor.22457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835201PMC
December 2013

microRNAs and cartilage.

J Orthop Res 2013 Sep 10;31(9):1333-44. Epub 2013 Jun 10.

Bone and Joint Center, Henry Ford Hospital, Detroit, Michigan, USA.

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http://dx.doi.org/10.1002/jor.22397DOI Listing
September 2013

MicroRNAs-140-5p/140-3p modulate Leydig cell numbers in the developing mouse testis.

Biol Reprod 2013 Jun 6;88(6):143. Epub 2013 Jun 6.

Division of Molecular Genetics and Development, Institute for Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia.

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http://dx.doi.org/10.1095/biolreprod.113.107607DOI Listing
June 2013

Chromatin assembly and in vitro transcription analyses for evaluation of individual protein activities in multicomponent transcriptional complexes.

Methods Mol Biol 2013 ;977:193-202

Department of Orthopaedic Surgery, Okayama University Graduate School, Shikata-cho, Okayama, Japan.

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http://dx.doi.org/10.1007/978-1-62703-284-1_15DOI Listing
August 2013

[Joint and microRNA].

Nihon Rinsho Meneki Gakkai Kaishi 2012 ;35(6):447-54

Department of Systems BioMedicine, Graduate School and Faculty of Medicine, Tokyo Medical and Dental University.

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http://dx.doi.org/10.2177/jsci.35.447DOI Listing
December 2013

A systems approach and skeletal myogenesis.

Comp Funct Genomics 2012 6;2012:759407. Epub 2012 Sep 6.

Department of Systems BioMedicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Bunkyo, Tokyo 113-8510, Japan ; Department of Systems BioMedicine, National Research Institute for Child Health and Development, Setagaya, Tokyo 157-8535, Japan.

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http://www.hindawi.com/journals/ijg/2012/759407/
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http://dx.doi.org/10.1155/2012/759407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443578PMC
September 2012

Macro view of microRNA function in osteoarthritis.

Nat Rev Rheumatol 2012 Sep 14;8(9):543-52. Epub 2012 Aug 14.

Department of Regenerative Medicine, Hiroshima University Hospital, 1-2-3 Kasumi, Hiroshima 734-8551, Japan.

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http://dx.doi.org/10.1038/nrrheum.2012.128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572197PMC
September 2012

Identification of novel transcription-regulating genes expressed during murine molar development.

Dev Dyn 2012 Jul 6;241(7):1217-26. Epub 2012 Jun 6.

Department of Systems BioMedicine, National Research Institute for Child Health and Development, Setagaya, Japan.

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http://dx.doi.org/10.1002/dvdy.23808DOI Listing
July 2012

[miRNAs in cartilage development].

Authors:
Hiroshi Asahara

Clin Calcium 2012 May;22(5):653-7

Department of Systems BioMedicine, Tokyo Medical and Dental University, Japan.

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http://dx.doi.org/CliCa1205653657DOI Listing
May 2012

L-Sox5 and Sox6 proteins enhance chondrogenic miR-140 microRNA expression by strengthening dimeric Sox9 activity.

J Biol Chem 2012 Jun 30;287(26):22206-15. Epub 2012 Apr 30.

Department of Systems Biomedicine, National Research Institute for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo 157-8535, Japan.

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http://dx.doi.org/10.1074/jbc.M112.343194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381182PMC
June 2012

Complex genomic rearrangement in the SOX9 5' region in a patient with Pierre Robin sequence and hypoplastic left scapula.

Am J Med Genet A 2012 Jul 23;158A(7):1529-34. Epub 2012 Apr 23.

Department of Molecular Endocrinology, National Research Institute for Child Health and Development, Tokyo, Japan.

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http://dx.doi.org/10.1002/ajmg.a.35308DOI Listing
July 2012

Structural and functional maturation of distal femoral cartilage and bone during postnatal development and growth in humans and mice.

Orthop Clin North Am 2012 Apr 21;43(2):173-85, v. Epub 2012 Feb 21.

Department of Bioengineering, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0412, USA.

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http://dx.doi.org/10.1016/j.ocl.2012.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321216PMC
April 2012

Current strategies for microRNA research.

Mod Rheumatol 2012 Sep 12;22(5):645-53. Epub 2012 Jan 12.

Department of Systems BioMedicine, National Research Institute for Child Health and Development, 2-10-1 Okura, Setagaya, Tokyo 157-8535, Japan.

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http://dx.doi.org/10.1007/s10165-011-0583-8DOI Listing
September 2012

Translational suppression of atrophic regulators by microRNA-23a integrates resistance to skeletal muscle atrophy.

J Biol Chem 2011 Nov 18;286(44):38456-65. Epub 2011 Sep 18.

Division of Regenerative Medical Engineering, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo, Tokyo 113-0033, Japan.

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http://www.jbc.org/content/286/44/38456.full.pdf
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http://www.jbc.org/cgi/doi/10.1074/jbc.M111.271270
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http://dx.doi.org/10.1074/jbc.M111.271270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207415PMC
November 2011

[Analysis of molecular network in chondrocytes by WISH].

Clin Calcium 2011 Jun;21(6):831-8

The Scripps Research Institute.

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http://dx.doi.org/CliCa1106831838DOI Listing
June 2011

Adiponectin enhances insulin sensitivity by increasing hepatic IRS-2 expression via a macrophage-derived IL-6-dependent pathway.

Cell Metab 2011 Apr;13(4):401-412

Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo 113-8655, Japan; Translational Systems Biology and Medicine Initiative (TSBMI), University of Tokyo, Tokyo 113-8655, Japan. Electronic address:

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http://linkinghub.elsevier.com/retrieve/pii/S155041311100083
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http://dx.doi.org/10.1016/j.cmet.2011.02.010DOI Listing
April 2011

The myogenic transcriptional network.

Cell Mol Life Sci 2011 Jun 12;68(11):1843-9. Epub 2011 Feb 12.

Department of Systems Biomedicine, National Research Institute for Child Health and Development, Setagaya, Tokyo 157-8535, Japan.

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http://link.springer.com/10.1007/s00018-011-0629-2
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http://dx.doi.org/10.1007/s00018-011-0629-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092062PMC
June 2011

Switching gears to an arthritis gene expression network by SirT1 cleavage.

Authors:
Hiroshi Asahara

Arthritis Rheum 2011 Aug;63(8):2161-3

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http://dx.doi.org/10.1002/art.30276DOI Listing
August 2011

Histone acetylation influences the activity of Sox9-related transcriptional complex.

Acta Med Okayama 2010 Dec;64(6):351-7

Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine,Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.

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http://dx.doi.org/10.18926/AMO/41320DOI Listing
December 2010

Developmental expression of sorting nexin 3 in the mouse central nervous system.

Gene Expr Patterns 2011 Jan-Feb;11(1-2):33-40. Epub 2010 Sep 9.

Department of Pharmacology, National Research Institute for Child Health and Development, Setagaya, Tokyo 157-8535, Japan.

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http://dx.doi.org/10.1016/j.gep.2010.08.007DOI Listing
March 2011

The Mohawk homeobox gene is a critical regulator of tendon differentiation.

Proc Natl Acad Sci U S A 2010 Jun 24;107(23):10538-42. Epub 2010 May 24.

Department of Systems BioMedicine, National Research Institute for Child Health and Development, Tokyo 157-8535, Japan.

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http://dx.doi.org/10.1073/pnas.1000525107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890854PMC
June 2010

Extracellular sulfatases support cartilage homeostasis by regulating BMP and FGF signaling pathways.

Proc Natl Acad Sci U S A 2010 Jun 17;107(22):10202-7. Epub 2010 May 17.

Department of Molecular and Experimental Medicine and Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1073/pnas.0913897107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890424PMC
June 2010

Correlation between MMP-13 and HDAC7 expression in human knee osteoarthritis.

Mod Rheumatol 2010 Feb 26;20(1):11-7. Epub 2009 Sep 26.

Division of Arthritis Research, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA.

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http://dx.doi.org/10.1007/s10165-009-0224-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2818344PMC
February 2010

Large-scale whole mount in situ hybridization of mouse embryos.

Methods Mol Biol 2009 ;577:167-79

Department of Systems Biomedicine, National Research Institute for Child Health and Development, Tokyo, Japan.

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http://dx.doi.org/10.1007/978-1-60761-232-2_13DOI Listing
February 2010

Induction of apoptosis in the synovium of mice with autoantibody-mediated arthritis by the intraarticular injection of double-stranded MicroRNA-15a.

Arthritis Rheum 2009 Sep;60(9):2677-83

Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, Japan.

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http://doi.wiley.com/10.1002/art.24762
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September 2009

MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates interleukin-1 responses.

Arthritis Rheum 2009 Sep;60(9):2723-30

Department of Molecular and Experimental Medicine, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1002/art.24745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806094PMC
September 2009

Tissue neogenesis and STRO-1 expression in immature and mature articular cartilage.

J Orthop Res 2010 Jan;28(1):96-102

Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

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http://doi.wiley.com/10.1002/jor.20944
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http://dx.doi.org/10.1002/jor.20944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2905317PMC
January 2010

Mesenchymal progenitor cell markers in human articular cartilage: normal distribution and changes in osteoarthritis.

Arthritis Res Ther 2009 5;11(3):R85. Epub 2009 Jun 5.

Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1186/ar2719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714136PMC
March 2010

Real-time functional imaging for monitoring miR-133 during myogenic differentiation.

Int J Biochem Cell Biol 2009 Nov 4;41(11):2225-31. Epub 2009 May 4.

Research Institute for Cell Engineering (RICE), National Institute of Advanced Industrial Science and Technology (AIST), Central 4, 1-1-1 Higashi, Tsukuba 305-8562, Japan.

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http://dx.doi.org/10.1016/j.biocel.2009.04.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806093PMC
November 2009