Publications by authors named "Hiroo Amano"

73 Publications

TNF-α inhibitor-induced paradoxical psoriasis and erythema nodosum in a patient with ankylosing spondylitis.

Eur J Dermatol 2021 Jun;31(3):412-413

Department of Dermatology, Iwate Medical University School of Medicine, 2-1-1, Idaidori, Yahaba-cho, Iwate 028-3695, Japan.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1684/ejd.2021.4058DOI Listing
June 2021

Case report of meningeal carcinomatosis in advanced cutaneous apocrine carcinoma.

J Dermatol 2021 Jul 6. Epub 2021 Jul 6.

Department of Dermatology, School of Medicine, Iwate Medical University, Shiwa-gun, Japan.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/1346-8138.16055DOI Listing
July 2021

Lipid transfer protein syndrome due to wild grape juice and various vegetables: A life-threatening food allergen.

J Dermatol 2021 Jun 11. Epub 2021 Jun 11.

Department of Dermatology, Iwate Medical University School of Medicine, Shiwa-gun, Japan.

We report a 16-year-old Japanese male with mugwort pollinosis in whom ingestion of wild grape juice and various vegetables caused recurrent general urticaria, abdominal pain, dyspnea, and loss of consciousness. A skin prick test demonstrated positive reactions to a wide variety of both non-heated and heated vegetables and fruits such as wild grape, bell pepper, onion, Chinese cabbage, tomato, eggplant, and broccoli. The serum immunoglobulin E levels (ImmunoCAP ISAC ) for Art v 3, Pla a 3, Pru p 3, and Jug r 3, which are lipid transfer protein (LTP) homologs, were positive but those for Bet v 1 and Bet v 2 were negative. We diagnosed the patient as having LTP syndrome, a condition in which additional factors such as exercise, non-steroidal anti-inflammatory drugs, or alcohol may trigger an allergic reaction. Wild grapes contain a large amount of salicylic acid, and in our patient ingestion of wild grape juice led to immediate loss of consciousness in the absence of exercise. This suggests that salicylic acid contained in fruits and vegetables may act as an important cofactor in LTP syndrome. Although sensitization to LTP is rarely reported in Asia, LTP are considered to be potentially life-threatening food allergens, and therefore warrant attention.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/1346-8138.16010DOI Listing
June 2021

Development of arthralgia during treatment with dupilumab in a patient with atopic dermatitis.

J Dermatol 2021 May 14. Epub 2021 May 14.

Department of Dermatology, Iwate Medical University School of Medicine, Iwate, Japan.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/1346-8138.15965DOI Listing
May 2021

A case of a gibberellin-regulated protein-positive patient allergic to various fruits.

Eur J Dermatol 2021 Feb;31(1):88-90

Department of Dermatology, Iwate Medical University School of Medicine, Japan.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1684/ejd.2020.3949DOI Listing
February 2021

A case of perioperative allergic reaction caused by rocuronium and atropine.

JAAD Case Rep 2021 Jan 12;7:84-86. Epub 2020 Nov 12.

Department of Dermatology, School of Medicine, Iwate Medical University, Yahaba-cho, Japan.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jdcr.2020.11.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7736702PMC
January 2021

Successful treatment of adalimumab-induced paradoxical psoriatic arthritis with risankizumab.

Eur J Dermatol 2020 Oct;30(5):611-612

Department of Dermatology, Iwate Medical University School of Medicine, 2-1-1, Idaidori, Yahabacho, Iwate 028-3695, Japan.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1684/ejd.2020.3859DOI Listing
October 2020

Angiosarcoma of the Auricle in a Patient with Xeroderma Pigmentosum Variant.

Case Rep Dermatol 2020 May-Aug;12(2):144-149. Epub 2020 Aug 18.

Department of Dermatology, Iwate Medical University School of Medicine, Yahaba-cho, Japan.

Xeroderma pigmentosum (XP) is an inherited autosomal recessive disorder characterized by photosensitivity and an increased risk of developing multiple skin neoplasms at sites exposed to the sun. We report a 73-year-old Japanese man with angiosarcoma of the auricle and an XP-variant, which is a very rare condition. In this case, long-term physical stimulation due to auricular deformation after surgery may have been the cause. Angiosarcoma associated with XP has a better prognosis than common angiosarcoma, perhaps because of the smaller tumor size. As XP patients are at high risk of skin neoplasms, they consult dermatologists regularly, and therefore skin tumors are likely to be detected early.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1159/000508884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7506222PMC
August 2020

Development of psoriasis during docetaxel therapy in a patient with non-small-cell lung cancer.

J Dermatol 2020 Dec 3;47(12):e427-e428. Epub 2020 Sep 3.

Department of Dermatology, Iwate Medical University School of Medicine, Iwate, Japan.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/1346-8138.15587DOI Listing
December 2020

Effectiveness of Combined Anti-programmed Death-ligand 1 Therapy and Radiotherapy for Metastatic Merkel Cell Carcinoma: Two Case Reports.

Acta Derm Venereol 2020 Aug 18;100(15):adv00237. Epub 2020 Aug 18.

Department of Dermatology, Iwate Medical University School of Medicine, 1-1-1 Idaidori, Yahaba-cho, Shiwa-gun, Iwate Prefecture 028-3694, Japan. E-mail:

is missing (Short communication).
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.2340/00015555-3593DOI Listing
August 2020

Hair abnormality in Netherton syndrome observed under polarized light microscopy.

J Am Acad Dermatol 2020 Sep 3;83(3):847-853. Epub 2020 Feb 3.

University of the Ryukyus, Graduate School of Medicine, Okinawa, Japan. Electronic address:

Background: Trichorrhexis invaginata, the main diagnostic feature of Netherton syndrome, is often difficult to detect, especially in adult patients.

Objective: We sought to describe a characteristic feature of hairs in Netherton syndrome using a polarized light microscope and the underlying histopathologic changes.

Methods: Hairs obtained from 8 patients with Netherton syndrome were observed under polarized light, and we evaluated the correlation between number of band-like patterns and disease severity.

Results: Under polarized microscopy, the hair shafts of 8 patients showed a characteristic band-like pattern under polarized light that was not observed in healthy control individuals or patients with atopic dermatitis. This discontinuity of polarized light shows a band-like pattern in which the bands mostly ranged from 0.1 to 1.0 mm in width. The observed ratio of this finding was significantly higher than that of trichorrhexis invaginata observed under light microscopy, and patients with severe dermatitis tended to have a higher ratio than those with less severe dermatitis.

Limitations: Comparative examination among other congenital ichthyoses was not performed.

Conclusions: A band-like pattern in hairs with polarized light microscopy can be seen in Netherton syndrome and may have potential utility as a diagnostic marker.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaad.2019.08.024DOI Listing
September 2020

Six cases of perforating pilomatricoma: Anetodermic changes with expression of matrix metalloproteinases.

J Dermatol 2020 Jan 1;47(1):82-85. Epub 2019 Nov 1.

Department of Dermatology, Iwate Medical University School of Medicine, Morioka, Japan.

Perforating pilomatricoma (PP) is a rare clinical variant of pilomatricoma presenting as a crusted or ulcerated nodule. Previous reports have suggested that the tumor cells perforate the epidermis through a process of transepithelial elimination. Here, we report six cases of PP and examine the mechanism of transepithelial elimination in PP. Histologically, the dermis above or around the tumor nest exhibited edema, dilated vascular spaces, sparse collagen bundles and absence of elastic fibers, suggesting anetodermic changes in all cases. Immunohistochemistry demonstrated many CD68-positive macrophages around the tumor nests. Matrix metallopeptidase (MMP)-9 and MMP-12 were expressed in the inflammatory cells and tumor cells, and were also present in the epidermis and fibroblasts in all cases. We speculate that in PP anetodermic change caused by MMP and elastases including MMP-9 and MMP-12 may precede elimination of the tumor.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/1346-8138.15138DOI Listing
January 2020

Occupational contact dermatitis in a manicurist.

J Dermatol 2019 Nov 4;46(11):1039-1041. Epub 2019 Sep 4.

Department of Dermatology, Iwate Medical University School of Medicine, Morioka, Japan.

We report a case of a manicurist who developed an allergic skin reaction to acrylates, manifested by itchy erythema, papules, vesicles and fissures on her hands, fingertips, forearm and eyelids. Patch tests showed positive reactions to three nail products used: ethylene glycol dimethacrylate, 2-hydroxyethyl methacrylate, ethyl acrylate and 2-hydroxyethyl acrylate in (meth)acrylate series. By using gel nail products, our patient became sensitized to 2-hydroxyethyl methacrylate. We assume that this had been the trigger, leading to the occurrence of cross-reactions between numerous acrylates including ethylene glycol dimethacrylate, ethyl acrylate and 2-hydroxyethyl acrylate. When handling nail products, it is necessary to prevent airway sensitization, contact sensitization and cross-reaction between various acrylates.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/1346-8138.15062DOI Listing
November 2019

Meningeal Carcinomatosis in Advanced Extramammary Paget's Disease: A Case Report.

Acta Derm Venereol 2019 Jul;99(9):826-827

Department of Dermatology, Iwate Medical University, 0208505 Morioka, Japan.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.2340/00015555-3211DOI Listing
July 2019

A case of anaphylactic reaction to chamomile tea in a patient with mugwort pollinosis.

Allergol Int 2019 Jul 3;68(3):396-398. Epub 2019 Apr 3.

Department of Dermatology, Iwate Medical University, School of Medicine, Morioka, Japan. Electronic address:

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alit.2019.02.011DOI Listing
July 2019

Unilateral Remission of Psoriasis Associated with a Spinal Arteriovenous Malformation.

Acta Derm Venereol 2019 Jun;99(7):681-682

Department of Dermatology, Iwate Medical University School of Medicine, 19-1 Uchimaru, Morioka, 0208505 Morioka, Japan.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.2340/00015555-3177DOI Listing
June 2019

Evaluation of Sentinel Lymph Node Biopsy for Eccrine Porocarcinoma.

Acta Derm Venereol 2019 Jun;99(7):691-692

Department of Dermatology, Iwate medical University, 020-8505 Morioka, Japan.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.2340/00015555-3173DOI Listing
June 2019

Cross-sectional survey on disease severity in Japanese patients with harlequin ichthyosis/ichthyosis: Syndromic forms and quality-of-life analysis in a subgroup.

J Dermatol Sci 2018 Nov 11;92(2):127-133. Epub 2018 Sep 11.

Department of Dermatology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8560, Japan. Electronic address:

Background: Congenital ichthyoses (CIs) adversely affect quality of life (QOL) in patients. However, the effects of CIs on patient QOL have not been studied sufficiently.

Objective: To investigate the association between disease severity and QOL in patients with harlequin ichthyosis (HI) and ichthyosis: syndromic forms (ISFs) METHODS: Clinical information of patients with HI and ISFs from 2010 to 2015 were obtained from 100 dermatology departments/divisions of principal institutes/hospitals throughout Japan. We examined the relationship between disease severity and QOL in patients with HI and ISFs. Patients who were aged 8 years or older and participated in a multicenter retrospective questionnaire survey in Japan were assessed by dermatology life quality index (DLQI, range of 0-30) and clinical ichthyosis score (range of 0-100).

Results: Netherton syndrome patients had a significantly higher risk of allergy to food or environmental allergens than patients with other phenotypes. Keratitis-ichthyosis-deafness (KID) syndrome patients showed a significantly higher risk of skin infections than patients with other phenotypes. Complete data on DLQI were obtained from 13 patients, whose median age was 21 (8-71) years. Nine patients were male, and 4 were female. Systemic retinoids were administrated to 2 of the 3 HI patients. The Spearman's correlation coefficient between the clinical ichthyosis score and DLQI was 0.611 (P < 0.05).

Conclusion: We confirmed that Netherton syndrome and KID syndrome patients have a higher risk of allergy to food or environmental allergens and of skin infections, respectively. QOL impairment correlates with disease severity in HI and ISFs patients.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jdermsci.2018.08.008DOI Listing
November 2018

Monitoring serum cytokeratin 19 fragment 21-1 to determine the efficacy of docetaxel chemotherapy in advanced extramammary Paget's disease.

J Dermatol 2019 Mar 8;46(3):e83-e84. Epub 2018 Sep 8.

Department of Dermatology, Iwate Medical University School of Medicine, Morioka, Japan.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/1346-8138.14627DOI Listing
March 2019

Successful treatment of erythematotelangiectatic rosacea with intense pulsed light: Report of 13 cases.

J Dermatol 2018 Sep 28;45(9):1113-1116. Epub 2018 Jun 28.

Department of Dermatology, Iwate Medical University School of Medicine, Morioka, Japan.

Here, we describe the use of intense pulsed light (IPL) treatment for 13 cases of erythematotelangiectatic rosacea delivered in three sessions. For two-step irradiation, after the whole face had been irradiated using conventional IPL equipment covering a wide area, localized IPL spot irradiation was performed for visibly dilated capillaries. The therapeutic effect was evaluated by image analysis using Image J and scored by 10 dermatologists using two IPL instruments in combination. This therapeutic approach was found to be much more effective than irradiation using a single instrument. Our findings demonstrate that IPL irradiation using the present method can deliver a sufficient therapeutic effect even with a small number of treatment sessions. Although rosacea is difficult to treat, we believe that IPL can be therapeutically useful in such cases.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/1346-8138.14513DOI Listing
September 2018

Psoriasis-like Dermatitis in Adulthood: A Skin Manifestation of Holocarboxylase Synthetase Deficiency.

Acta Derm Venereol 2018 Aug;98(8):805-806

Department of Dermatology, Iwate Medical University School of Medicine, 19-1 Uchimaru, Morioka, Iwate 020-8505, Japan.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.2340/00015555-2954DOI Listing
August 2018

In-frame Val-Ser deletion of KIT in mild piebaldism causes aberrant secretion and SCF response.

J Dermatol Sci 2018 Jul 21;91(1):35-42. Epub 2018 Mar 21.

Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan. Electronic address:

Background: Piebaldism is a pigmentary disorder characterized by a white forelock and depigmented patches. Although the loss-of-function mutations in the KIT gene underlie the disease, the intracellular dynamics of the mutant KIT are largely unknown. We herein report a Japanese family with piebaldism in which the affected members showed a mild phenotype.

Objective: The objective of this study is to investigate the functions and intracellular dynamics of the mutant KIT protein.

Methods: We performed genetic analyses of the KIT gene using peripheral blood cells. We analyzed the intracellular localization of the mutant KIT protein in HEK293T cells transfected with wild-type (Wt) and/or mutant KIT genes. Immunoprecipitation analyses, immunoblotting and immunofluorescence studies were performed using antibodies against KIT and downstream signaling proteins. Glycosidase digestion analysis was performed to clarify the intracellular localization of KIT protein.

Results: A genetic analysis revealed a novel heterozygous mutation c.645_650delTGTGTC which results in the in-frame deletion of Val and Ser in the extracellular domain of KIT. Immunoprecipitation analyses confirmed that the wild and mutant KIT formed a heterodimer after treatment with stem cell factor (SCF); however, the phosphorylation of the downstream signaling factors was decreased. In an immunofluorescence study, the mutant KIT accumulated predominantly in the endoplasmic reticulum (ER) and was sparsely expressed on the cell surface. A glycosidase digestion study revealed that the mutant KIT is predominantly localized in the ER.

Conclusion: These data reveal an aberrant function and intracellular localization of mutant KIT protein in piebaldism.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jdermsci.2018.03.012DOI Listing
July 2018

Analysis of cancer-associated fibroblasts and the epithelial-mesenchymal transition in cutaneous basal cell carcinoma, squamous cell carcinoma, and malignant melanoma.

Hum Pathol 2018 09 16;79:1-8. Epub 2018 Mar 16.

Department of Plastic Surgery, School of Medicine, Iwate Medical University, Morioka 020-8505, Japan.

Activated cancer-associated fibroblasts (CAFs) and fibroblasts that have undergone the epithelial-mesenchymal transition (EMT) in cancer stroma contribute to tumor progression and metastasis. However, no reports have investigated the CAF phenotype and its clinicopathological relevance in cutaneous malignant tumors, including basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and malignant melanoma (MM). Here, we investigated the CAF phenotype in cutaneous malignant tumors based on their histology and immunohistochemical expression of CAF-related markers, including adipocyte enhancer-binding protein 1 (AEBP1), podoplanin, platelet-derived growth factor receptor α (PDGFRα), PDGFRβ, fibroblast activating protein (FAP), CD10, S100A4, α-smooth muscle actin (α-SMA), and EMT-related markers (Zeb1, Slug, and Twist). In addition, we assessed the role of the CAF phenotype in cutaneous malignant cancers using hierarchical cluster analysis. Consequently, 3 subgroups were stratified based on the expression pattern of CAF- and EMT-related markers. Subgroup 1 was characterized by low expression of AEBP1, PDGFRα, PDGFRβ, FAP and Slug, whereas subgroup 2 was closely associated with high expression of PDGFRβ, S100A4 and Twist. In addition, high expression levels of podoplanin, PDGFRβ, CD10, S100A4, α-SMA, Zeb1, Slug and Twist were observed in subgroup 3. High expression of CD10 was commonly found in all 3 subgroups. These subgroups were correlated with histologic subtypes, that is, subgroup 1, MM; subgroup 2, BCC; and subgroup 3, SCC. We suggest that the expression pattern of CAF- and EMT-related proteins plays crucial roles in the progression of BCC, SCC, and MM.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.humpath.2018.03.006DOI Listing
September 2018

Carnosic acid, an inducer of NAD(P)H quinone oxidoreductase 1, enhances the cytotoxicity of β-lapachone in melanoma cell lines.

Oncol Lett 2018 Feb 14;15(2):2393-2400. Epub 2017 Dec 14.

Department of Tumor Biology, Institute of Biomedical Science, Iwate Medical University, Iwate 028-8505, Japan.

NAD(P)H quinone oxidoreductase 1 (NQO1)-dependent antitumor drugs such as β-lapachone (β-lap) are attractive candidates for cancer chemotherapy because several tumors exhibit higher expression of NQO1 than adjacent tissues. Although the association between NQO1 and β-lap has been elucidated, the effects of a NQO1-inducer and β-lap used in combination remain to be clarified. It has previously been reported that melanoma cell lines have detectable levels of NQO1 expression and are sensitive to NQO1-dependent drugs such as 17-allylamino-17-demethoxygeldanamycin. The present study was conducted to investigate the involvement of NQO1 in β-lap-mediated toxicity and the utility of combination treatment with a NQO1-inducer and β-lap in malignant melanoma cell lines. Decreased expression or inhibition of NQO1 caused these cell lines to become less sensitive to β-lap, indicating a requirement of NQO1 activity for β-lap-mediated toxicity. Of note was that carnosic acid (CA), a compound extracted from rosemary, was able to induce further expression of NQO1 through NF-E2 related factor 2 (NRF2) stabilization, thus significantly enhancing the cytotoxicity of β-lap in all of the melanoma cell lines tested. Taken together, the data presented in the current study indicated that the NRF2-NQO1 axis may have potential value as a therapeutic target in malignant melanoma to improve the rate of clinical response to NQO1-dependent antitumor drugs.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3892/ol.2017.7618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777343PMC
February 2018

Case of classic Kaposi sarcoma of the penis successfully treated with radiotherapy.

J Dermatol 2018 Jul 16;45(7):e175-e176. Epub 2018 Jan 16.

Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Japan.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/1346-8138.14220DOI Listing
July 2018

Keratosis follicularis squamosa (Dohi) successfully treated with benzoyl peroxide 2.5% gel.

J Dermatol 2018 Apr 13;45(4):e70-e71. Epub 2017 Nov 13.

Department of Dermatology, Iwate Medical University School of Medicine, Morioka, Japan.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/1346-8138.14128DOI Listing
April 2018

Trigeminal trophic syndrome: Analysis of the number of peripheral nerve fibres and blood vessels in the lesional skin.

Australas J Dermatol 2018 Feb 10;59(1):59-61. Epub 2017 Jul 10.

Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/ajd.12647DOI Listing
February 2018

Localized cutaneous immunoglobulin light chain kappa-positive amyloidosis associated with juvenile dermatomyositis.

J Dermatol 2017 Aug 13;44(8):e198-e199. Epub 2017 Apr 13.

Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Japan.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/1346-8138.13856DOI Listing
August 2017

Four cases of Morbihan disease successfully treated with doxycycline.

J Dermatol 2017 Jun 2;44(6):713-716. Epub 2017 Feb 2.

Department of Dermatology, School of Medicine, Iwate Medical University, Morioka, Japan.

Morbihan disease (MD) is rosacea-like disease characterized by persistent lymphedema on the upper half of the face. Currently, there is no established standard treatment for MD. Recently, MD has been reported to be associated with the infiltration of mast cells. The aim of this study was to investigate the association of treatment response and mast cell infiltration in MD. We report four cases of MD that were successfully treated with long-term oral doxycycline therapy.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/1346-8138.13756DOI Listing
June 2017

Pyogenic granuloma possibly associated with capecitabine therapy.

J Dermatol 2017 Nov 18;44(11):1329-1331. Epub 2016 Nov 18.

Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Japan.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/1346-8138.13691DOI Listing
November 2017
-->