Publications

Transforming growth factor β-inhibitor Repsox downregulates collagen expression of scleroderma dermal fibroblasts and prevents bleomycin-induced mice skin fibrosis.
Exp Dermatol 2017 Nov 25;26(11):1139-1143. Epub 2017 Aug 25.
Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.


The role of miR-210, E2F3 and ephrin A3 in angiosarcoma cell proliferation.
Eur J Dermatol 2017 Oct;27(5):464-471
Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan.

Chronic sun exposure-related fusion oncogenes EGFR-PPARGC1A in cutaneous squamous cell carcinoma.
Sci Rep 2017 Oct 4;7(1):12654. Epub 2017 Oct 4.
Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.


Raltegravir blocks the infectivity of red-fluorescent-protein (mCherry)-labeled HIV-1JR-FL in the setting of post-exposure prophylaxis in NOD/SCID/Jak3-/- mice transplanted with human PBMCs.
Antiviral Res 2017 Sep 8;149:78-88. Epub 2017 Sep 8.
Departments of Hematology and Infectious Diseases, Kumamoto University Graduate School of Biomedical Sciences, Japan; Experimental Retrovirology Section, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA; Experimental Retrovirology Section, Department of Refractory Viral Infection, National Center for Global Health and Medicine Research Institute, Tokyo, Japan. Electronic address:

Early phase dynamics of traceable mCherry fluorescent protein-carrying HIV-1 infection in human peripheral blood mononuclear cells-transplanted NOD/SCID/Jak3-/- mice.
Antiviral Res 2017 Aug 7;144:83-92. Epub 2017 Apr 7.
Experimental Retrovirology Section, Department of Refractory Viral Infection, National Center for Global Health and Medicine Research Institute, Tokyo, Japan; Departments of Hematology and Infectious Diseases, Kumamoto University Graduate School of Biomedical Sciences, Japan; Experimental Retrovirology Section, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address:



Cytokine biomarkers to predict antitumor responses to nivolumab suggested in a phase 2 study for advanced melanoma.
Cancer Sci 2017 May 11;108(5):1022-1031. Epub 2017 May 11.
Department of Surgery and Bioengineering, Advanced Clinical Research Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.



Safety and tolerability of bosentan for digital ulcers in Japanese patients with systemic sclerosis: Prospective, multicenter, open-label study.
J Dermatol 2017 Jan 4;44(1):13-17. Epub 2016 Jul 4.
Department of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.

Dysregulated interleukin-23 signalling contributes to the increased collagen production in scleroderma fibroblasts via balancing microRNA expression.
Rheumatology (Oxford) 2017 Jan 15;56(1):145-155. Epub 2016 Oct 15.
Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku Kumamoto, Japan.

Small bowel perforation due to indistinguishable metastasis of angiosarcoma: case report and brief literature review.
Surg Case Rep 2016 Dec 8;2(1):42. Epub 2016 May 8.
Department of Gastroenterological Surgery, Kumamoto University Graduate School of Medical Sciences, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.




microRNA level is raised in the hair shafts of patients with dematomyositis in comparison with normal subjects and patients with scleroderma.
Int J Dermatol 2016 Jul 24;55(7):786-90. Epub 2015 Oct 24.
Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.





Immunotherapy against Metastatic Melanoma with Human iPS Cell-Derived Myeloid Cell Lines Producing Type I Interferons.
Cancer Immunol Res 2016 Mar 29;4(3):248-58. Epub 2015 Dec 29.
Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.

Prognostic Significance of CD169+ Lymph Node Sinus Macrophages in Patients with Malignant Melanoma.
Cancer Immunol Res 2015 Dec 21;3(12):1356-63. Epub 2015 Aug 21.
Department of Cell Pathology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.

Expression of Let-7 family microRNAs in skin correlates negatively with severity of pulmonary hypertension in patients with systemic scleroderma.
Int J Cardiol Heart Vasc 2015 Sep 18;8:98-102. Epub 2015 Jun 18.
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.

Mice overexpressing integrin αv in fibroblasts exhibit dermal thinning of the skin.
J Dermatol Sci 2015 Sep 22;79(3):268-78. Epub 2015 Jun 22.
Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Honjo 1-1-1, Kumamoto 860-8556, Japan.

miR-205 down-regulation promotes proliferation of dermatofibrosarcoma protuberans tumor cells by regulating LRP-1 and ERK phosphorylation.
Arch Dermatol Res 2014 May 14;306(4):367-74. Epub 2014 Feb 14.
Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, Japan.


Correlated expression levels of endothelin receptor B and Plexin C1 in melanoma.
Am J Cancer Res 2015 15;5(3):1117-23. Epub 2015 Feb 15.
Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi 466-8550, Japan ; Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University Kasugai-shi, Aichi 487-8501, Japan.


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