Hiromitsu Takayama

Department of Biofunctional Molecular Chemistry, Graduate School of Pharmaceutical Sciences , Chiba University , 1-8-1 Inohana , Chuo-ku , Chiba 260-8675 , Japan.

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December 2018

Protective Effects of Brain Infarction by -Acetylcysteine Derivatives.

Authors:

Takeshi Uemura Kenta Watanabe Kenta Ko Kyohei Higashi Noriyuki Kogure Mariko Kitajima Hiromitsu Takayama Koichi Takao Yoshiaki Sugita Akihiko Sakamoto Yusuke Terui Toshihiko Toida Keiko Kashiwagi Kazuei Igarashi

Stroke 2018 07 4;49(7):1727-1733. Epub 2018 Jun 4.

From the Amine Pharma Research Institute, Innovation Plaza at Chiba University, Japan (T.U., K.I.)

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July 2018

A Cyclopeptide and a Tetrahydroisoquinoline Alkaloid from Ophiorrhiza nutans.

Authors:

Tadayoshi Onozawa Mariko Kitajima Noriyuki Kogure Nichakan Peerakam Dammrong Santiarworn Hiromitsu Takayama

J Nat Prod 2017 07 20;80(7):2156-2160. Epub 2017 Jul 20.

Department of Biofunctional Molecular Chemistry, Graduate School of Pharmaceutical Sciences, Chiba University , 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.

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July 2017

Asymmetric Total Synthesis of Pentacyclic Indole Alkaloid Andranginine and Absolute Configuration of Natural Product Isolated from Kopsia arborea.

Authors:

Shino Tooriyama Yuji Mimori Yuqiu Wu Noriyuki Kogure Mariko Kitajima Hiromitsu Takayama

Org Lett 2017 05 8;19(10):2722-2725. Epub 2017 May 8.

Graduate School of Pharmaceutical Sciences, Chiba University , 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.

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May 2017

Identification of novel glutathione adducts of benzbromarone in human liver microsomes.

Authors:

Naoki Cho Kaoru Kobayashi Mina Yoshida Noriyuki Kogure Hiromitsu Takayama Kan Chiba

Drug Metab Pharmacokinet 2017 Feb 27;32(1):46-52. Epub 2016 Oct 27.

Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, 260-8675, Japan.

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February 2017

Characterization of a recently evolved flavonol-phenylacyltransferase gene provides signatures of natural light selection in Brassicaceae.

Authors:

Takayuki Tohge Regina Wendenburg Hirofumi Ishihara Ryo Nakabayashi Mutsumi Watanabe Ronan Sulpice Rainer Hoefgen Hiromitsu Takayama Kazuki Saito Mark Stitt Alisdair R Fernie

Nat Commun 2016 08 22;7:12399. Epub 2016 Aug 22.

Max-Planck-Institute of Molecular Plant Physiology, Am Mühlenberg 1, 14476 Potsdam-Golm, Germany.

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August 2016

Asymmetric Total Synthesis of Kopsiyunnanine K, a Monoterpenoid Indole Alkaloid with a Rearranged Skeleton.

Authors:

Ryoko Tokuda Yoshiki Okamoto Tetsuya Koyama Noriyuki Kogure Mariko Kitajima Hiromitsu Takayama

Org Lett 2016 07 29;18(14):3490-3. Epub 2016 Jun 29.

Graduate School of Pharmaceutical Sciences, Chiba University , 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.

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July 2016

Asymmetric Total Synthesis of Sarpagine-Related Indole Alkaloids Hydroxygardnerine, Hydroxygardnutine, Gardnerine, (E)-16-epi-Normacusine B, and Koumine.

Authors:

Mariko Kitajima Keisuke Watanabe Hiroyuki Maeda Noriyuki Kogure Hiromitsu Takayama

Org Lett 2016 Apr 1;18(8):1912-5. Epub 2016 Apr 1.

Graduate School of Pharmaceutical Sciences, Chiba University , 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.

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April 2016

New Lycopodine-Type Alkaloids from Lycopodium carinatum.

Authors:

Noriyuki Kogure Moe Maruyama Sumphan Wongseripipatana Mariko Kitajima Hiromitsu Takayama

Chem Pharm Bull (Tokyo) 2016 Jul 25;64(7):793-9. Epub 2016 Mar 25.

Graduate School of Pharmaceutical Sciences, Chiba University.

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July 2016

Monoterpenoid Bisindole Alkaloids.

Authors:

Mariko Kitajima Hiromitsu Takayama

Alkaloids Chem Biol 2016 21;76:259-310. Epub 2015 Oct 21.

Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.

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July 2016

Boosting Sensitivity in Liquid Chromatography-Fourier Transform Ion Cyclotron Resonance-Tandem Mass Spectrometry for Product Ion Analysis of Monoterpene Indole Alkaloids.

Authors:

Ryo Nakabayashi Hiroshi Tsugawa Mariko Kitajima Hiromitsu Takayama Kazuki Saito

Front Plant Sci 2015 17;6:1127. Epub 2015 Dec 17.

RIKEN Center for Sustainable Resource ScienceYokohama, Japan; Graduate School of Pharmaceutical Sciences, Chiba UniversityChiba, Japan.

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January 2016

The first asymmetric total synthesis of lycoposerramine-R.

Authors:

Hiroaki Ishida Shinya Kimura Noriyuki Kogure Mariko Kitajima Hiromitsu Takayama

Org Biomol Chem 2015 Jul;13(28):7762-71

Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.

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July 2015

Kopsiyunnanines J1 and J2, new strychnos-type homo-monoterpenoid indole alkaloids from Kopsia arborea.

Authors:

Mariko Kitajima Tetsuya Koyama Yuqiu Wu Noriyuki Kogure Rongping Zhang Hiromitsu Takayama

Nat Prod Commun 2015 Jan;10(1):49-51

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January 2015

Iridoids and a norsesquiterpenoid from the leaves of Villaria odorata.

Authors:

Mario A Tan Raychel Ann U Villacorta Jonathan D Alejandro Hiromitsu Takayama

Nat Prod Commun 2014 Sep;9(9):1229-30

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September 2014

Asymmetric total synthesis of novel pentacyclic indole alkaloid, kopsiyunnanine E, isolated from Kopsia arborea.

Authors:

Mariko Kitajima Yosuke Murakami Nobuaki Takahashi Yuqiu Wu Noriyuki Kogure Rong-Ping Zhang Hiromitsu Takayama

Org Lett 2014 Oct 24;16(19):5000-3. Epub 2014 Sep 24.

Graduate School of Pharmaceutical Sciences, Chiba University , 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.

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October 2014

Biogenetically inspired total syntheses of Lycopodium alkaloids, (+)-flabellidine and (-)-lycodine.

Authors:

Masayuki Azuma Tetsuya Yoshikawa Noriyuki Kogure Mariko Kitajima Hiromitsu Takayama

J Am Chem Soc 2014 Aug 11;136(33):11618-21. Epub 2014 Aug 11.

Graduate School of Pharmaceutical Sciences, Chiba University , 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.

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August 2014

Identification of Indole Alkaloid Structural Units Important for Stimulus-Selective TRPM8 Inhibition: SAR Study of Naturally Occurring Iboga Derivatives.

Authors:

Yuko Terada Mariko Kitajima Fuyumi Taguchi Hiromitsu Takayama Syunji Horie Tatsuo Watanabe

J Nat Prod 2014 Aug;77(8):1831-8

Graduate School of Nutritional and Environmental Sciences, University of Shizuoka , 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.

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August 2014

A flavonoid 3-O-glucoside:2"-O-glucosyltransferase responsible for terminal modification of pollen-specific flavonols in Arabidopsis thaliana.

Authors:

Keiko Yonekura-Sakakibara Ryo Nakabayashi Satoko Sugawara Takayuki Tohge Takuya Ito Misuzu Koyanagi Mariko Kitajima Hiromitsu Takayama Kazuki Saito

Plant J 2014 Sep 28;79(5):769-82. Epub 2014 Jul 28.

RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, 230-0045, Japan.

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September 2014

Activation and inhibition of thermosensitive TRP channels by voacangine, an alkaloid present in Voacanga africana, an African tree.

Authors:

Yuko Terada Syunji Horie Hiromitsu Takayama Kunitoshi Uchida Makoto Tominaga Tatsuo Watanabe

J Nat Prod 2014 Feb 31;77(2):285-97. Epub 2014 Jan 31.

Graduate School of Nutritional and Environmental Sciences, University of Shizuoka , 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.

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February 2014

Orally active opioid μ/δ dual agonist MGM-16, a derivative of the indole alkaloid mitragynine, exhibits potent antiallodynic effect on neuropathic pain in mice.

Authors:

Kenjiro Matsumoto Minoru Narita Naotaka Muramatsu Terumi Nakayama Kaori Misawa Mariko Kitajima Kimihito Tashima Lakshmi A Devi Tsutomu Suzuki Hiromitsu Takayama Syunji Horie

J Pharmacol Exp Ther 2014 Mar 17;348(3):383-92. Epub 2013 Dec 17.

Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Josai International University, Chiba, Japan (K.Ma., N.M., K.T., S.H.); Department of Toxicology (K.Ma., M.N., T.S.) and Department of Pharmacology (K.Ma., M.N.), Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan; Department of Molecular Structure and Biological Function, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan (T.N., K.Mi., M.K., H.T.); and Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York (L.A.D.).

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March 2014

Asymmetric total synthesis of an iboga-type indole alkaloid, voacangalactone, newly isolated from Voacanga africana.

Authors:

Masaya Harada Ken Nunettsu Asaba Masumi Iwai Noriyuki Kogure Mariko Kitajima Hiromitsu Takayama

Org Lett 2012 Nov 6;14(22):5800-3. Epub 2012 Nov 6.

Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chiba 260-8675, Japan.

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November 2012

Experimental colitis alters expression of 5-HT receptors and transient receptor potential vanilloid 1 leading to visceral hypersensitivity in mice.

Authors:

Kenjiro Matsumoto Mee Wah Lo Takuji Hosoya Kimihito Tashima Hiromitsu Takayama Toshihiko Murayama Syunji Horie

Lab Invest 2012 May 13;92(5):769-82. Epub 2012 Feb 13.

Laboratory of Pharmacology, Josai International University, Togane, Chiba, Japan.

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May 2012

Two new alkaloids from Crinum asiaticum var. sinicum.

Authors:

Noriyuki Kogure Noriko Katsuta Mariko Kitajima Hiromitsu Takayama

Chem Pharm Bull (Tokyo) 2011 ;59(12):1545-8

Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260–8675, Japan.

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March 2012

Asymmetric total synthesis of a pentacyclic Lycopodium alkaloid: huperzine-Q.

Authors:

Atsushi Nakayama Noriyuki Kogure Mariko Kitajima Hiromitsu Takayama

Angew Chem Int Ed Engl 2011 Aug 12;50(35):8025-8. Epub 2011 Jul 12.

Graduate School of Pharmaceutical Sciences, Chiba University, Yayoi-cho, Inage-ku, Chiba, Japan.

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August 2011

Design, Synthesis, and Antitumor Activity of 4-Halocolchicines and Their Pro-drugs Activated by Cathepsin B.

Authors:

Naoko Yasobu Mariko Kitajima Noriyuki Kogure Yoshiyuki Shishido Takeshi Matsuzaki Masato Nagaoka Hiromitsu Takayama

ACS Med Chem Lett 2011 May 4;2(5):348-52. Epub 2011 Mar 4.

Graduate School of Pharmaceutical Sciences, Chiba University.

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May 2011

Lycopodium alkaloids: isolation and asymmetric synthesis.

Authors:

Mariko Kitajima Hiromitsu Takayama

Top Curr Chem 2012 ;309:1-31

Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

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April 2012

Bioactive metabolites of Diaporthe sp. P133, an endophytic fungus isolated from Pandanus amaryllifolius.

Authors:

Melfei E Bungihan Mario A Tan Mariko Kitajima Noriyuki Kogure Scott G Franzblau Thomas Edison E Dela Cruz Hiromitsu Takayama Maribel G Nonato

J Nat Med 2011 Jul 11;65(3-4):606-9. Epub 2011 Mar 11.

University of Santo Tomas, España, Manila, Philippines.

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July 2011

Total synthesis guided structure elucidation of (+)-psychotetramine.

Authors:

Klement Foo Timothy Newhouse Ikue Mori Hiromitsu Takayama Phil S Baran

Angew Chem Int Ed Engl 2011 Mar 17;50(12):2716-9. Epub 2011 Feb 17.

Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA.

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March 2011

Discovery of indole alkaloids with cannabinoid CB1 receptor antagonistic activity.

Authors:

Mariko Kitajima Masumi Iwai Ruri Kikura-Hanajiri Yukihiro Goda Mitsuru Iida Hisatoshi Yabushita Hiromitsu Takayama

Bioorg Med Chem Lett 2011 Apr 13;21(7):1962-4. Epub 2011 Feb 13.

Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

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April 2011

Inhibitory effect of Iboga-type indole alkaloids on capsaicin-induced contraction in isolated mouse rectum.

Authors:

Mee Wah Lo Kenjiro Matsumoto Masumi Iwai Kimihito Tashima Mariko Kitajima Syunji Horie Hiromitsu Takayama

J Nat Med 2011 Jan 2;65(1):157-65. Epub 2010 Nov 2.

Department of Biofunctional Molecular Chemistry, Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

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January 2011

Seven new monoterpenoid indole alkaloids from Gelsemium elegans.

Authors:

Yousuke Yamada Mariko Kitajima Noriyuki Kogure Sumphan Wongseripipatana Hiromitsu Takayama

Chem Asian J 2011 Jan;6(1):166-73

Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

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January 2011

Isolation of pandamarilactonine-H from the roots of Pandanus amaryllifolius and synthesis of epi-pandamarilactonine-H.

Authors:

Mario A Tan Mariko Kitajima Noriyuki Kogure Maribel G Nonato Hiromitsu Takayama

J Nat Prod 2010 Aug;73(8):1453-5

Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

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August 2010

Two new aspidosperma indole alkaloids from Yunnan Kopsia arborea.

Authors:

Yuqiu Wu Mariko Kitajima Noriyuki Kogure Yunsong Wang Rongping Zhang Hiromitsu Takayama

Chem Pharm Bull (Tokyo) 2010 Jul;58(7):961-3

Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.

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July 2010

Amides, triterpene and flavonoids from the leaves of Melastoma malabathricum L.

Authors:

Hasnah M Sirat Deny Susanti Farediah Ahmad Hiromitsu Takayama Mariko Kitajima

J Nat Med 2010 Oct 26;64(4):492-5. Epub 2010 Jun 26.

Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, 81310, Skudai, Johor, Malaysia.

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October 2010

Determination of absolute configuration of trimeric indole alkaloid, psychotrimine, by first asymmetric total synthesis.

Authors:

Nobuaki Takahashi Takeshi Ito Yohei Matsuda Noriyuki Kogure Mariko Kitajima Hiromitsu Takayama

Chem Commun (Camb) 2010 Apr 1;46(14):2501-3. Epub 2010 Feb 1.

Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

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April 2010

Asymmetric total syntheses of cyclic nitrone-containing phlegmarine-type Lycopodium alkaloids, lycoposerramines-X and -Z.

Authors:

Tomoyuki Tanaka Noriyuki Kogure Mariko Kitajima Hiromitsu Takayama

J Org Chem 2009 Nov;74(22):8675-80

Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

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November 2009

First asymmetric total syntheses of fawcettimine-type Lycopodium alkaloids, lycoposerramine-C and phlegmariurine-A.

Authors:

Atsushi Nakayama Noriyuki Kogure Mariko Kitajima Hiromitsu Takayama

Org Lett 2009 Dec;11(23):5554-7

Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

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December 2009

Prenylated flavones from Artocarpus lanceifolius and their cytotoxic properties against P-388 cells.

Authors:

Iqbal Musthapa Jalifah Latip Hiromitsu Takayama Lia D Juliawaty Euis H Hakim Yana M Syah

Nat Prod Commun 2009 Jul;4(7):927-30

Department of Chemistry, Institut Teknologi Bandung, Jalan Ganesha 10, Bandung 40132, Indonesia.

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July 2009

Metabolomics-oriented isolation and structure elucidation of 37 compounds including two anthocyanins from Arabidopsis thaliana.

Authors:

Ryo Nakabayashi Miyako Kusano Makoto Kobayashi Takayuki Tohge Keiko Yonekura-Sakakibara Noriyuki Kogure Mami Yamazaki Mariko Kitajima Kazuki Saito Hiromitsu Takayama

Phytochemistry 2009 May 3;70(8):1017-29. Epub 2009 Jun 3.

Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

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May 2009

Kopsiyunnanines F and isocondylocarpines: new tubotaiwine-type alkaloids from Yunnan Kopsia arborea.

Authors:

Yuqiu Wu Mariko Kitajima Noriyuki Kogure Yunsong Wang Rongping Zhang Hiromitsu Takayama

J Nat Med 2009 Jul 28;63(3):283-9. Epub 2009 Apr 28.

Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba, 263-8522, Japan.

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July 2009

The botanical origin of kratom (Mitragyna speciosa; Rubiaceae) available as abused drugs in the Japanese markets.

Authors:

Takuro Maruyama Maiko Kawamura Ruri Kikura-Hanajiri Hiromitsu Takayama Yukihiro Goda

J Nat Med 2009 Jul 18;63(3):340-4. Epub 2009 Mar 18.

National Institute of Health Sciences, Division of Pharmacognosy, Phytochemistry and Narcotics, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo, 158-8501, Japan.

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July 2009

Rhazinilam and quebrachamine derivatives from Yunnan Kopsia arborea.

Authors:

Yuqiu Wu Mayu Suehiro Mariko Kitajima Takeshi Matsuzaki Shusuke Hashimoto Masato Nagaoka Rongping Zhang Hiromitsu Takayama

J Nat Prod 2009 Feb;72(2):204-9

Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

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February 2009

Pandanus alkaloids: chemistry and biology.

Authors:

Maribel G Nonato Hiromitsu Takayama Mary J Garson

Alkaloids Chem Biol 2008 ;66:215-49

Research Center for the Natural Sciences, College of Science, Graduate School, University of Santo Tomas, España, Manila 1015, Philippines.

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December 2008

New lycorine-type alkaloid from Lycoris traubii and evaluation of antitrypanosomal and antimalarial activities of lycorine derivatives.

Authors:

Yosuke Toriizuka Eri Kinoshita Noriyuki Kogure Mariko Kitajima Aki Ishiyama Kazuhiko Otoguro Haruki Yamada Satoshi Omura Hiromitsu Takayama

Bioorg Med Chem 2008 Dec 30;16(24):10182-9. Epub 2008 Oct 30.

Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

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December 2008

Comprehensive flavonol profiling and transcriptome coexpression analysis leading to decoding gene-metabolite correlations in Arabidopsis.

Authors:

Keiko Yonekura-Sakakibara Takayuki Tohge Fumio Matsuda Ryo Nakabayashi Hiromitsu Takayama Rie Niida Akiko Watanabe-Takahashi Eri Inoue Kazuki Saito

Plant Cell 2008 Aug 29;20(8):2160-76. Epub 2008 Aug 29.

RIKEN Plant Science Center, Tsurumi-ku, Yokohama 230-0045, Japan.

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August 2008

MGM-9 [(E)-methyl 2-(3-ethyl-7a,12a-(epoxyethanoxy)-9-fluoro-1,2,3,4,6,7,12,12b-octahydro-8-methoxyindolo[2,3-a]quinolizin-2-yl)-3-methoxyacrylate], a derivative of the indole alkaloid mitragynine: a novel dual-acting mu- and kappa-opioid agonist with potent antinociceptive and weak rewarding effects in mice.

Authors:

Kenjiro Matsumoto Hiromitsu Takayama Minoru Narita Atsushi Nakamura Masami Suzuki Tsutomu Suzuki Toshihiko Murayama Sumphan Wongseripipatana Kaori Misawa Mariko Kitajima Kimihito Tashima Syunji Horie

Neuropharmacology 2008 Aug 9;55(2):154-65. Epub 2008 May 9.

Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Josai International University, 1 Gumyo, Togane, Chiba 283-8555, Japan.

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August 2008

New iridoids from Gelsemium species.

Authors:

Noriyuki Kogure Naoko Ishii Hiromi Kobayashi Mariko Kitajima Sumphan Wongseripipatana Hiromitsu Takayama

Chem Pharm Bull (Tokyo) 2008 Jun;56(6):870-2

Graduate School of Pharmaceutical Sciences, Chiba University, Japan.

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June 2008

First asymmetric total syntheses of cernuane-type Lycopodium alkaloids, cernuine, and cermizine D.

Authors:

Yasuhiro Nishikawa Mariko Kitajima Hiromitsu Takayama

Org Lett 2008 May 23;10(10):1987-90. Epub 2008 Apr 23.

Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

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May 2008

Flavonols from Bauhinia malabarica.

Authors:

Rawiwun Kaewamatawong Mariko Kitajima Noriyuki Kogure Hiromitsu Takayama

J Nat Med 2008 Jul 15;62(3):364-5. Epub 2008 Apr 15.

Faculty of Pharmaceutical Sciences, Ubon Ratchatani University, Warinchamrap, Ubon Ratchathani Province, 34190, Thailand.

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July 2008

Antitubercular triterpenes and phytosterols from Pandanus tectorius Soland. var. laevis.

Authors:

Mario A Tan Hiromitsu Takayama Norio Aimi Mariko Kitajima Scott G Franzblau Maribel G Nonato

J Nat Med 2008 Apr 14;62(2):232-5. Epub 2007 Dec 14.

Research Center for the Natural Sciences, Graduate School and College of Science, University of Santo Tomas, España, 1015, Manila, Philippines.

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April 2008

Phenolic constituents from the wood of Morus australis with cytotoxic activity.

Authors:

Ferlinahayati Yana M Syah Lia D Juliawaty Sjamsul A Achmad Euis H Hakim Hiromitsu Takayama Ikram M Said Jalifah Latip

Z Naturforsch C J Biosci 2008 Jan-Feb;63(1-2):35-9

Department of Chemistry, Institut Teknologi Bandung, Jalan Ganesha 10, Bandung 40132, Indonesia.

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May 2008

Phytochemical and biological investigation of Hymenocallis littoralis SALISB.

Authors:

Amina H Abou-Donia Soad M Toaima Hala M Hammoda Eman Shawky Eri Kinoshita Hiromitsu Takayama

Chem Biodivers 2008 Feb;5(2):332-40

Faculty of Pharmacy, Pharmacognosy Department, University of Alexandria, Alexandria 21521, Egypt.

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February 2008

First total synthesis of trimeric indole alkaloid, psychotrimine.

Authors:

Yohei Matsuda Mariko Kitajima Hiromitsu Takayama

Org Lett 2008 Jan 11;10(1):125-8. Epub 2007 Dec 11.

Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 263-8522, Japan.

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January 2008

Asymmetric total syntheses of two phlegmarine-type alkaloids, lycoposerramines-V and -W, newly isolated from Lycopodium serratum.

Authors:

Takahide Shigeyama Kazuaki Katakawa Noriyuki Kogure Mariko Kitajima Hiromitsu Takayama

Org Lett 2007 Sep 8;9(20):4069-72. Epub 2007 Sep 8.

Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

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September 2007

Metabolic profiling of flavonoids in Lotus japonicus using liquid chromatography Fourier transform ion cyclotron resonance mass spectrometry.

Authors:

Hideyuki Suzuki Ryosuke Sasaki Yoshiyuki Ogata Yukiko Nakamura Nozomu Sakurai Mariko Kitajima Hiromitsu Takayama Shigehiko Kanaya Koh Aoki Daisuke Shibata Kazuki Saito

Phytochemistry 2008 Jan 31;69(1):99-111. Epub 2007 Jul 31.

Kazusa DNA Research Institute, Kazusa-Kamatari 2-6-7, Kisarazu 292-0818, Japan.

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January 2008

Design, synthesis, and biological evaluation of tricyclic heterocycle-tetraamine conjugates as potent NMDA channel blockers.

Authors:

Hiromitsu Takayama Yuichi Yaegashi Mariko Kitajima Xia Han Kazuhiro Nishimura Shigeru Okuyama Kazuei Igarashi

Bioorg Med Chem Lett 2007 Sep 27;17(17):4729-32. Epub 2007 Jun 27.

Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.

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September 2007

Fawcettimine-related alkaloids from Lycopodium serratum.

Authors:

Kazuaki Katakawa Akiko Nozoe Noriyuki Kogure Mariko Kitajima Masakiyo Hosokawa Hiromitsu Takayama

J Nat Prod 2007 Jun 16;70(6):1024-8. Epub 2007 May 16.

Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

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June 2007

New procedure to mask the 2,3-pi bond of the indole nucleus and its application to the preparation of potent opioid receptor agonists with a Corynanthe skeleton.

Authors:

Hiromitsu Takayama Kaori Misawa Naoki Okada Hayato Ishikawa Mariko Kitajima Yoshio Hatori Toshihiko Murayama Sumphan Wongseripipatana Kimihito Tashima Kenjiro Matsumoto Syunji Horie

Org Lett 2006 Dec;8(25):5705-8

Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 263-8522, Japan.

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December 2006

Comparative studies of anthraquinone- and anthracene-tetraamines as blockers of N-methyl-D-aspartate receptors.

Authors:

Lihua Jin Hiromi Sugiyama Miki Takigawa Daisuke Katagiri Hideyuki Tomitori Kazuhiro Nishimura Navneet Kaur Otto Phanstiel Mariko Kitajima Hiromitsu Takayama Tadashi Okawara Keith Williams Keiko Kashiwagi Kazuei Igarashi

J Pharmacol Exp Ther 2007 Jan 18;320(1):47-55. Epub 2006 Oct 18.

Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.

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January 2007

First asymmetric total syntheses of (-)-subincanadines a and B, skeletally rearranged pentacyclic monoterpenoid indole alkaloids in aspidospermasubincanum.

Authors:

Kenta Suzuki Hiromitsu Takayama

Org Lett 2006 Sep;8(20):4605-8

Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

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September 2006

Involvement of mu-opioid receptors in antinociception and inhibition of gastrointestinal transit induced by 7-hydroxymitragynine, isolated from Thai herbal medicine Mitragyna speciosa.

Authors:

Kenjiro Matsumoto Yoshio Hatori Toshihiko Murayama Kimihito Tashima Sumphan Wongseripipatana Kaori Misawa Mariko Kitajima Hiromitsu Takayama Syunji Horie

Eur J Pharmacol 2006 Nov 16;549(1-3):63-70. Epub 2006 Aug 16.

Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Josai International University, 1 Gumyo, Togane, Chiba 283-8555, Japan.

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November 2006

Prenylated flavonoids and related compounds of the Indonesian Artocarpus (Moraceae).

Authors:

Euis H Hakim Sjamsul A Achmad Lia D Juliawaty Lukman Makmur Yana M Syah Norio Aimi Mariko Kitajima Hiromitsu Takayama Emilio L Ghisalberti

J Nat Med 2006 Jul 25;60(3):161-184. Epub 2006 May 25.

Chemistry, School of Biomedical and Chemical Sciences, The University of Western Australia, Crawley, WA, 6909, Australia.

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July 2006

Four novel gelsenicine-related oxindole alkaloids from the leaves of Gelsemium elegans benth.

Authors:

Noriyuki Kogure Naoko Ishii Mariko Kitajima Sumphan Wongseripipatana Hiromitsu Takayama

Org Lett 2006 Jul;8(14):3085-8

Graduate School of Pharmaceutical Sciences, Chiba University, Inage-ku, Japan.

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July 2006

Cytotoxic chalcones and flavanones from the tree bark of Cryptocarya costata.

Authors:

Hanapi Usman Euis H Hakim Tjodi Harlim Muhammad N Jalaluddin Yana M Syah Sjamsul A Achmad Hiromitsu Takayama

Z Naturforsch C J Biosci 2006 Mar-Apr;61(3-4):184-8

Chemistry Department, Hasanuddin University, Jalan Perintis Kemerdekaan, Makassar, Indonesia.

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August 2006

Isolation of gelsedine-type indole alkaloids from Gelsemium elegans and evaluation of the cytotoxic activity of gelsemium alkaloids for A431 epidermoid carcinoma cells.

Authors:

Mariko Kitajima Tomonori Nakamura Noriyuki Kogure Mio Ogawa Yuka Mitsuno Kageyoshi Ono Shingo Yano Norio Aimi Hiromitsu Takayama

J Nat Prod 2006 Apr;69(4):715-8

Department of Molecular Structure and Biological Function, Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

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April 2006

Partial agonistic effect of 9-hydroxycorynantheidine on mu-opioid receptor in the guinea-pig ileum.

Authors:

Kenjiro Matsumoto Hiromitsu Takayama Hayato Ishikawa Norio Aimi Dhavadee Ponglux Kazuo Watanabe Syunji Horie

Life Sci 2006 Apr 2;78(19):2265-71. Epub 2005 Nov 2.

Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Josai International University, Togane, Chiba, Japan.

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April 2006

Camptothecins and two new monoterpene glucosides from Ophiorrhiza liukiuensis.

Authors:

Mariko Kitajima Norie Fujii Fumie Yoshino Hiroshi Sudo Kazuki Saito Norio Aimi Hiromitsu Takayama

Chem Pharm Bull (Tokyo) 2005 Oct;53(10):1355-8

Graduate School of Pharmaceutical Sciences, Chiba University.

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October 2005

Antinociception, tolerance and withdrawal symptoms induced by 7-hydroxymitragynine, an alkaloid from the Thai medicinal herb Mitragyna speciosa.

Authors:

Kenjiro Matsumoto Syunji Horie Hiromitsu Takayama Hayato Ishikawa Norio Aimi Dhavadee Ponglux Toshihiko Murayama Kazuo Watanabe

Life Sci 2005 Nov 15;78(1):2-7. Epub 2005 Sep 15.

Laboratory of Pharmacolgy, Faculty of Pharmaceutical Sciences, Josai International University, 1 Gumyo, Togane, Chiba 283-8555, Japan.

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November 2005

Inhibitory effect of mitragynine, an analgesic alkaloid from Thai herbal medicine, on neurogenic contraction of the vas deferens.

Authors:

Kenjiro Matsumoto Leonardo T Yamamoto Kazuo Watanabe Shingo Yano Jie Shan Peter K T Pang Dhavadee Ponglux Hiromitsu Takayama Syunji Horie

Life Sci 2005 Nov 16;78(2):187-94. Epub 2005 Aug 16.

Department of Pharmacology, Faculty of Pharmaceutical Sciences, Josai International University, 1 Gumyo, Togane, Chiba 283-8555, Japan.

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November 2005

Potentially cytotoxic triterpenoids from the root bark of Siphonodon celastrineus Griff.

Authors:

Chokchai Niampoka Rutt Suttisri Rapepol Bavovada Hiromitsu Takayama Norio Aimi

Arch Pharm Res 2005 May;28(5):546-9

Department of Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.

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May 2005

Suppressive effects of isorhynchophylline on 5-HT2A receptor function in the brain: behavioural and electrophysiological studies.

Authors:

Kinzo Matsumoto Ryo Morishige Yukihisa Murakami Michihisa Tohda Hiromitsu Takayama Iwao Sakakibara Hiroshi Watanabe

Eur J Pharmacol 2005 Jul;517(3):191-9

Division of Medicinal Pharmacology, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan.

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July 2005

Corymine potentiates NMDA-induced currents in Xenopus oocytes expressing NR1a/NR2B glutamate receptors.

Authors:

Pathama Leewanich Michihisa Tohda Hiromitsu Takayama Samaisukh Sophasan Hiroshi Watanabe Kinzo Matsumoto

J Pharmacol Sci 2005 May 12;98(1):58-65. Epub 2005 May 12.

Department of Pharmacology, Faculty of Medicine, Srinakharinwirot University, Bangkok 10110, Thailand.

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May 2005

Indole alkaloids of a Thai medicinal herb, Mitragyna speciosa, that has opioid agonistic effect in guinea-pig ileum.

Authors:

Syunji Horie Fumi Koyama Hiromitsu Takayama Hayato Ishikawa Norio Aimi Dhavadee Ponglux Kenjiro Matsumoto Toshihiko Murayama

Planta Med 2005 Mar;71(3):231-6

Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.

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March 2005

Structure elucidation and synthesis of lycoposerramine-B, a novel oxime-containing Lycopodium alkaloid from Lycopodium serratum Thunb.

Authors:

Kazuaki Katakawa Mariko Kitajima Norio Aimi Hiroko Seki Kentaro Yamaguchi Kazuo Furihata Takashi Harayama Hiromitsu Takayama

J Org Chem 2005 Jan;70(2):658-63

Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

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January 2005

Protective effect of rhynchophylline and isorhynchophylline on in vitro ischemia-induced neuronal damage in the hippocampus: putative neurotransmitter receptors involved in their action.

Authors:

Tai-Hyun Kang Yukihisa Murakami Hiromitsu Takayama Mariko Kitajima Norio Aimi Hiroshi Watanabe Kinzo Matsumoto

Life Sci 2004 Dec;76(3):331-43

Division of Pharmacology, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan.

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December 2004

New oleanan-type triterpene and cincholic acid glycosides from Peruvian "Uña de Gato" (Uncaria tomentosa).

Authors:

Mariko Kitajima Ken-Ichiro Hashimoto Manuel Sandoval Norio Aimi Hiromitsu Takayama

Chem Pharm Bull (Tokyo) 2004 Oct;52(10):1258-61

Graduate School of Pharmaceutical Sciences, Chiba University.

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October 2004

New type of trimeric and pentameric indole alkaloids from Psychotria rostrata.

Authors:

Hiromitsu Takayama Ikue Mori Mariko Kitajima Norio Aimi Nordin H Lajis

Org Lett 2004 Aug;6(17):2945-8

Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 263-8522, Japan.

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August 2004

Chemistry and pharmacology of analgesic indole alkaloids from the rubiaceous plant, Mitragyna speciosa.

Authors:

Hiromitsu Takayama

Chem Pharm Bull (Tokyo) 2004 Aug;52(8):916-28

Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.

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August 2004

Dimethylthioarsenicals as arsenic metabolites and their chemical preparations.

Authors:

Kazuo T Suzuki Badal K Mandal Akio Katagiri Yoko Sakuma Ayumi Kawakami Yasumitsu Ogra Kentaro Yamaguchi Yoshihisa Sei Kenzo Yamanaka Kazunori Anzai Masayoshi Ohmichi Hiromitsu Takayama Noriro Aimi

Chem Res Toxicol 2004 Jul;17(7):914-21

Department of Toxicology and Environmental Health, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260-8675, Japan.

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July 2004

A new 9-methoxyyohimbine-type indole alkaloid from Mitragyna africanus.

Authors:

Hiromitsu Takayama Hayato Ishikawa Mariko Kitajima Norio Aimi Baba Muhammad Aji

Chem Pharm Bull (Tokyo) 2004 Mar;52(3):359-61

Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.

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March 2004

Antinociceptive effect of 7-hydroxymitragynine in mice: Discovery of an orally active opioid analgesic from the Thai medicinal herb Mitragyna speciosa.

Authors:

Kenjiro Matsumoto Syunji Horie Hayato Ishikawa Hiromitsu Takayama Norio Aimi Dhavadee Ponglux Kazuo Watanabe

Life Sci 2004 Mar;74(17):2143-55

Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage, Chiba 263-8522, Japan.

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March 2004

Mesaconitine-induced relaxation in rat aorta: role of Na+/Ca2+ exchangers in endothelial cells.

Authors:

Junko Ogura Mana Mitamura Akiyoshi Someya Ken Shimamura Hiromitsu Takayama Norio Aimi Syunji Horie Toshihiko Murayama

Eur J Pharmacol 2004 Jan;483(2-3):139-46

Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 263-8522, Japan.

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January 2004

Biosynthesis of camptothecin. In silico and in vivo tracer study from [1-13C]glucose.

Authors:

Yasuyo Yamazaki Mariko Kitajima Masanori Arita Hiromitsu Takayama Hiroshi Sudo Mami Yamazaki Norio Aimi Kazuki Saito

Plant Physiol 2004 Jan 4;134(1):161-70. Epub 2003 Dec 4.

Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

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January 2004

New oxindole alkaloids and iridoid from Carolina jasmine (Gelsemium sempervirens Ait. f.).

Authors:

Mariko Kitajima Akiko Urano Noriyuki Kogure Hiromitsu Takayama Norio Aimi

Chem Pharm Bull (Tokyo) 2003 Oct;51(10):1211-4

Graduate School of Pharmaceutical Sciences, Chiba University, Japan.

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October 2003

Ten new Lycopodium alkaloids having the lycopodane skeleton isolated from Lycopodium serratum Thunb.

Authors:

Hiromitsu Takayama Kazuaki Katakawa Mariko Kitajima Kentaro Yamaguchi Norio Aimi

Chem Pharm Bull (Tokyo) 2003 Oct;51(10):1163-9

Graduate School of Pharmaceutical Sciences, Chiba University, Japan.

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October 2003

Pharmacological evidence for antidementia effect of Choto-san (Gouteng-san), a traditional Kampo medicine.

Authors:

Hiroshi Watanabe Qi Zhao Kinzo Matsumoto Michihisa Tohda Yukihisa Murakami Shao-Hui Zhang Tae-Hyun Kang Pramote Mahakunakorn Yukiko Maruyama Iwao Sakakibara Norio Aimi Hiromitsu Takayama

Pharmacol Biochem Behav 2003 Jun;75(3):635-43

Department of Pharmacology, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Toyama 930-0194, Japan.

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June 2003

Two oligostilbenes, cis- and trans-diptoindonesin B, from Dryobalanops oblongifolia.

Authors:

Yana M Syah Nanik S Aminah Euis H Hakim Norio Aimi Mariko Kitajima Hiromitsu Takayama Sjamsul A Achmad

Phytochemistry 2003 Aug;63(8):913-7

Natural Products Chemistry Group, Department of Chemistry, Institut Teknologi Bandung, Jalan Ganesha 10, 40132 Bandung, Indonesia.

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August 2003

First asymmetric total synthesis of Us-7 and -8, novel D-seco Corynanthe-type oxindole alkaloids from Uncaria attenuata: structure revision of Us-7 and determination of absolute stereochemistry.

Authors:

Hiromitsu Takayama Rika Fujiwara Yasuko Kasai Mariko Kitajima Norio Aimi

Org Lett 2003 Aug;5(16):2967-70

Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

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August 2003

Structure reinvestigation of gelsemoxonine, a constituent of Gelsemium elegans, reveals a novel, azetidine-containing indole alkaloid.

Authors:

Mariko Kitajima Noriyuki Kogure Kentaro Yamaguchi Hiromitsu Takayama Norio Aimi

Org Lett 2003 Jun;5(12):2075-8

Graduate School of Pharmaceutical Sciences and Chemical Analysis Center, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

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June 2003

Metabolite profiling of alkaloids and strictosidine synthase activity in camptothecin producing plants.

Authors:

Yasuyo Yamazaki Akiko Urano Hiroshi Sudo Mariko Kitajima Hiromitsu Takayama Mami Yamazaki Norio Aimi Kazuki Saito

Phytochemistry 2003 Feb;62(3):461-70

Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

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February 2003

Two new nor-triterpene glycosides from peruvian "Uña de Gato" (Uncaria tomentosa).

Authors:

Mariko Kitajima Ken-Ichiro Hashimoto Masashi Yokoya Hiromitsu Takayama Manuel Sandoval Norio Aimi

J Nat Prod 2003 Feb;66(2):320-3

Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

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February 2003

Publications by authors named "Hiromitsu Takayama"

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