Publications by authors named "Hiromitsu Takayama"

100Publications

Design, synthesis, and pharmacological evaluation of 2-(4-sulfonylphenyl)-2-[(E)-pyrrolidin-1-ylimino]-N-thiazoleacetamides as glucokinase activators.

Bioorg Med Chem Lett 2020 08 6;30(15):127249. Epub 2020 May 6.

Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba 260-8675, Japan.

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August 2020

Total Syntheses of Lycopodium and Monoterpenoid Indole Alkaloids Based on Biosynthesis-Inspired Strategies.

Chem Pharm Bull (Tokyo) 2020 ;68(2):103-116

Graduate School of Pharmaceutical Sciences, Chiba University.

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March 2020

Asymmetric Total Synthesis of Biphenylquinolizidine Alkaloids 4″--Demethyllythridine and 14--4″--Demethyllythridine.

Org Lett 2019 10 16;21(19):7982-7986. Epub 2019 Sep 16.

Graduate School of Pharmaceutical Sciences , Chiba University , 1-8-1 Inohana , Chuo-ku, Chiba 260-8675 , Japan.

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October 2019

Total Synthesis of (-)-14-Hydroxygelsenicine and Six Biogenetically Related Alkaloids.

Org Lett 2019 09 12;21(17):7134-7137. Epub 2019 Aug 12.

Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.

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September 2019

Total Syntheses of Pleiocarpamine, Normavacurine, and C-Mavacurine.

Org Lett 2019 05 18;21(9):3342-3345. Epub 2019 Apr 18.

Graduate School of Pharmaceutical Sciences , Chiba University , 1-8-1 Inohana, Chuo-ku , Chiba 260-8675 , Japan.

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May 2019

Asymmetric Total Synthesis of Fawcettimine-Type Lycopodium Alkaloid, Lycopoclavamine-A.

J Org Chem 2019 05 9;84(9):5645-5654. Epub 2019 Apr 9.

Graduate School of Pharmaceutical Sciences , Chiba University , 1-8-1 Inohana , Chuo-ku, Chiba 260-8675 , Japan.

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May 2019

Recent Progress in the Chemistry of Pandanus Alkaloids.

Alkaloids Chem Biol 2019 26;82:1-28. Epub 2019 Feb 26.

Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan. Electronic address:

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March 2019

New otonecine-type pyrrolizidine alkaloid from Petasites japonicus.

J Nat Med 2019 Jun 19;73(3):602-607. Epub 2019 Feb 19.

Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8675, Japan.

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June 2019

Asymmetric Total Synthesis and Evaluation of Antitumor Activity of Ophiorrhisine A and Its Derivatives.

J Org Chem 2018 12 4;83(24):15312-15322. Epub 2018 Dec 4.

Department of Biofunctional Molecular Chemistry, Graduate School of Pharmaceutical Sciences , Chiba University , 1-8-1 Inohana , Chuo-ku , Chiba 260-8675 , Japan.

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December 2018

A Cyclopeptide and a Tetrahydroisoquinoline Alkaloid from Ophiorrhiza nutans.

J Nat Prod 2017 07 20;80(7):2156-2160. Epub 2017 Jul 20.

Department of Biofunctional Molecular Chemistry, Graduate School of Pharmaceutical Sciences, Chiba University , 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.

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July 2017

Asymmetric Total Synthesis of Pentacyclic Indole Alkaloid Andranginine and Absolute Configuration of Natural Product Isolated from Kopsia arborea.

Org Lett 2017 05 8;19(10):2722-2725. Epub 2017 May 8.

Graduate School of Pharmaceutical Sciences, Chiba University , 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.

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May 2017

Identification of novel glutathione adducts of benzbromarone in human liver microsomes.

Drug Metab Pharmacokinet 2017 Feb 27;32(1):46-52. Epub 2016 Oct 27.

Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, 260-8675, Japan.

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February 2017

Asymmetric Total Synthesis of Kopsiyunnanine K, a Monoterpenoid Indole Alkaloid with a Rearranged Skeleton.

Org Lett 2016 07 29;18(14):3490-3. Epub 2016 Jun 29.

Graduate School of Pharmaceutical Sciences, Chiba University , 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.

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July 2016

Asymmetric Total Synthesis of Sarpagine-Related Indole Alkaloids Hydroxygardnerine, Hydroxygardnutine, Gardnerine, (E)-16-epi-Normacusine B, and Koumine.

Org Lett 2016 Apr 1;18(8):1912-5. Epub 2016 Apr 1.

Graduate School of Pharmaceutical Sciences, Chiba University , 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.

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April 2016

New Lycopodine-Type Alkaloids from Lycopodium carinatum.

Chem Pharm Bull (Tokyo) 2016 Jul 25;64(7):793-9. Epub 2016 Mar 25.

Graduate School of Pharmaceutical Sciences, Chiba University.

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July 2016

Monoterpenoid Bisindole Alkaloids.

Alkaloids Chem Biol 2016 21;76:259-310. Epub 2015 Oct 21.

Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.

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July 2016

Boosting Sensitivity in Liquid Chromatography-Fourier Transform Ion Cyclotron Resonance-Tandem Mass Spectrometry for Product Ion Analysis of Monoterpene Indole Alkaloids.

Front Plant Sci 2015 17;6:1127. Epub 2015 Dec 17.

RIKEN Center for Sustainable Resource ScienceYokohama, Japan; Graduate School of Pharmaceutical Sciences, Chiba UniversityChiba, Japan.

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January 2016

The first asymmetric total synthesis of lycoposerramine-R.

Org Biomol Chem 2015 Jul;13(28):7762-71

Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.

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July 2015

Asymmetric total synthesis of novel pentacyclic indole alkaloid, kopsiyunnanine E, isolated from Kopsia arborea.

Org Lett 2014 Oct 24;16(19):5000-3. Epub 2014 Sep 24.

Graduate School of Pharmaceutical Sciences, Chiba University , 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.

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October 2014

Biogenetically inspired total syntheses of Lycopodium alkaloids, (+)-flabellidine and (-)-lycodine.

J Am Chem Soc 2014 Aug 11;136(33):11618-21. Epub 2014 Aug 11.

Graduate School of Pharmaceutical Sciences, Chiba University , 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.

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August 2014

Identification of Indole Alkaloid Structural Units Important for Stimulus-Selective TRPM8 Inhibition: SAR Study of Naturally Occurring Iboga Derivatives.

J Nat Prod 2014 Aug;77(8):1831-8

Graduate School of Nutritional and Environmental Sciences, University of Shizuoka , 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.

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August 2014

Activation and inhibition of thermosensitive TRP channels by voacangine, an alkaloid present in Voacanga africana, an African tree.

J Nat Prod 2014 Feb 31;77(2):285-97. Epub 2014 Jan 31.

Graduate School of Nutritional and Environmental Sciences, University of Shizuoka , 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.

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February 2014

Orally active opioid μ/δ dual agonist MGM-16, a derivative of the indole alkaloid mitragynine, exhibits potent antiallodynic effect on neuropathic pain in mice.

J Pharmacol Exp Ther 2014 Mar 17;348(3):383-92. Epub 2013 Dec 17.

Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Josai International University, Chiba, Japan (K.Ma., N.M., K.T., S.H.); Department of Toxicology (K.Ma., M.N., T.S.) and Department of Pharmacology (K.Ma., M.N.), Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan; Department of Molecular Structure and Biological Function, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan (T.N., K.Mi., M.K., H.T.); and Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York (L.A.D.).

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March 2014

Asymmetric total synthesis of an iboga-type indole alkaloid, voacangalactone, newly isolated from Voacanga africana.

Org Lett 2012 Nov 6;14(22):5800-3. Epub 2012 Nov 6.

Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chiba 260-8675, Japan.

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November 2012

Two new alkaloids from Crinum asiaticum var. sinicum.

Chem Pharm Bull (Tokyo) 2011 ;59(12):1545-8

Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260–8675, Japan.

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March 2012

Asymmetric total synthesis of a pentacyclic Lycopodium alkaloid: huperzine-Q.

Angew Chem Int Ed Engl 2011 Aug 12;50(35):8025-8. Epub 2011 Jul 12.

Graduate School of Pharmaceutical Sciences, Chiba University, Yayoi-cho, Inage-ku, Chiba, Japan.

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August 2011

Lycopodium alkaloids: isolation and asymmetric synthesis.

Top Curr Chem 2012 ;309:1-31

Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

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April 2012

Total synthesis guided structure elucidation of (+)-psychotetramine.

Angew Chem Int Ed Engl 2011 Mar 17;50(12):2716-9. Epub 2011 Feb 17.

Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA.

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March 2011

Discovery of indole alkaloids with cannabinoid CB1 receptor antagonistic activity.

Bioorg Med Chem Lett 2011 Apr 13;21(7):1962-4. Epub 2011 Feb 13.

Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

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April 2011

Inhibitory effect of Iboga-type indole alkaloids on capsaicin-induced contraction in isolated mouse rectum.

J Nat Med 2011 Jan 2;65(1):157-65. Epub 2010 Nov 2.

Department of Biofunctional Molecular Chemistry, Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

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January 2011

Seven new monoterpenoid indole alkaloids from Gelsemium elegans.

Chem Asian J 2011 Jan;6(1):166-73

Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

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January 2011

Isolation of pandamarilactonine-H from the roots of Pandanus amaryllifolius and synthesis of epi-pandamarilactonine-H.

J Nat Prod 2010 Aug;73(8):1453-5

Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

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August 2010

Two new aspidosperma indole alkaloids from Yunnan Kopsia arborea.

Chem Pharm Bull (Tokyo) 2010 Jul;58(7):961-3

Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.

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July 2010

Amides, triterpene and flavonoids from the leaves of Melastoma malabathricum L.

J Nat Med 2010 Oct 26;64(4):492-5. Epub 2010 Jun 26.

Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, 81310, Skudai, Johor, Malaysia.

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October 2010

Determination of absolute configuration of trimeric indole alkaloid, psychotrimine, by first asymmetric total synthesis.

Chem Commun (Camb) 2010 Apr 1;46(14):2501-3. Epub 2010 Feb 1.

Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

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April 2010

Asymmetric total syntheses of cyclic nitrone-containing phlegmarine-type Lycopodium alkaloids, lycoposerramines-X and -Z.

J Org Chem 2009 Nov;74(22):8675-80

Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

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November 2009

First asymmetric total syntheses of fawcettimine-type Lycopodium alkaloids, lycoposerramine-C and phlegmariurine-A.

Org Lett 2009 Dec;11(23):5554-7

Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

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December 2009

Prenylated flavones from Artocarpus lanceifolius and their cytotoxic properties against P-388 cells.

Nat Prod Commun 2009 Jul;4(7):927-30

Department of Chemistry, Institut Teknologi Bandung, Jalan Ganesha 10, Bandung 40132, Indonesia.

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July 2009

Kopsiyunnanines F and isocondylocarpines: new tubotaiwine-type alkaloids from Yunnan Kopsia arborea.

J Nat Med 2009 Jul 28;63(3):283-9. Epub 2009 Apr 28.

Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba, 263-8522, Japan.

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July 2009

The botanical origin of kratom (Mitragyna speciosa; Rubiaceae) available as abused drugs in the Japanese markets.

J Nat Med 2009 Jul 18;63(3):340-4. Epub 2009 Mar 18.

National Institute of Health Sciences, Division of Pharmacognosy, Phytochemistry and Narcotics, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo, 158-8501, Japan.

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July 2009

Rhazinilam and quebrachamine derivatives from Yunnan Kopsia arborea.

J Nat Prod 2009 Feb;72(2):204-9

Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

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February 2009

Pandanus alkaloids: chemistry and biology.

Alkaloids Chem Biol 2008 ;66:215-49

Research Center for the Natural Sciences, College of Science, Graduate School, University of Santo Tomas, España, Manila 1015, Philippines.

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December 2008

New lycorine-type alkaloid from Lycoris traubii and evaluation of antitrypanosomal and antimalarial activities of lycorine derivatives.

Bioorg Med Chem 2008 Dec 30;16(24):10182-9. Epub 2008 Oct 30.

Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

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December 2008

New iridoids from Gelsemium species.

Chem Pharm Bull (Tokyo) 2008 Jun;56(6):870-2

Graduate School of Pharmaceutical Sciences, Chiba University, Japan.

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June 2008

First asymmetric total syntheses of cernuane-type Lycopodium alkaloids, cernuine, and cermizine D.

Org Lett 2008 May 23;10(10):1987-90. Epub 2008 Apr 23.

Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

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May 2008

Flavonols from Bauhinia malabarica.

J Nat Med 2008 Jul 15;62(3):364-5. Epub 2008 Apr 15.

Faculty of Pharmaceutical Sciences, Ubon Ratchatani University, Warinchamrap, Ubon Ratchathani Province, 34190, Thailand.

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July 2008

Antitubercular triterpenes and phytosterols from Pandanus tectorius Soland. var. laevis.

J Nat Med 2008 Apr 14;62(2):232-5. Epub 2007 Dec 14.

Research Center for the Natural Sciences, Graduate School and College of Science, University of Santo Tomas, España, 1015, Manila, Philippines.

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April 2008

Phenolic constituents from the wood of Morus australis with cytotoxic activity.

Z Naturforsch C J Biosci 2008 Jan-Feb;63(1-2):35-9

Department of Chemistry, Institut Teknologi Bandung, Jalan Ganesha 10, Bandung 40132, Indonesia.

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May 2008

Phytochemical and biological investigation of Hymenocallis littoralis SALISB.

Chem Biodivers 2008 Feb;5(2):332-40

Faculty of Pharmacy, Pharmacognosy Department, University of Alexandria, Alexandria 21521, Egypt.

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February 2008

First total synthesis of trimeric indole alkaloid, psychotrimine.

Org Lett 2008 Jan 11;10(1):125-8. Epub 2007 Dec 11.

Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 263-8522, Japan.

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January 2008

Asymmetric total syntheses of two phlegmarine-type alkaloids, lycoposerramines-V and -W, newly isolated from Lycopodium serratum.

Org Lett 2007 Sep 8;9(20):4069-72. Epub 2007 Sep 8.

Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

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September 2007

Design, synthesis, and biological evaluation of tricyclic heterocycle-tetraamine conjugates as potent NMDA channel blockers.

Bioorg Med Chem Lett 2007 Sep 27;17(17):4729-32. Epub 2007 Jun 27.

Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.

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September 2007

Fawcettimine-related alkaloids from Lycopodium serratum.

J Nat Prod 2007 Jun 16;70(6):1024-8. Epub 2007 May 16.

Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

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June 2007

First asymmetric total syntheses of (-)-subincanadines a and B, skeletally rearranged pentacyclic monoterpenoid indole alkaloids in aspidospermasubincanum.

Org Lett 2006 Sep;8(20):4605-8

Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

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September 2006

Prenylated flavonoids and related compounds of the Indonesian Artocarpus (Moraceae).

J Nat Med 2006 Jul 25;60(3):161-184. Epub 2006 May 25.

Chemistry, School of Biomedical and Chemical Sciences, The University of Western Australia, Crawley, WA, 6909, Australia.

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July 2006

Cytotoxic chalcones and flavanones from the tree bark of Cryptocarya costata.

Z Naturforsch C J Biosci 2006 Mar-Apr;61(3-4):184-8

Chemistry Department, Hasanuddin University, Jalan Perintis Kemerdekaan, Makassar, Indonesia.

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August 2006

Isolation of gelsedine-type indole alkaloids from Gelsemium elegans and evaluation of the cytotoxic activity of gelsemium alkaloids for A431 epidermoid carcinoma cells.

J Nat Prod 2006 Apr;69(4):715-8

Department of Molecular Structure and Biological Function, Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

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April 2006

Partial agonistic effect of 9-hydroxycorynantheidine on mu-opioid receptor in the guinea-pig ileum.

Life Sci 2006 Apr 2;78(19):2265-71. Epub 2005 Nov 2.

Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Josai International University, Togane, Chiba, Japan.

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April 2006

Camptothecins and two new monoterpene glucosides from Ophiorrhiza liukiuensis.

Chem Pharm Bull (Tokyo) 2005 Oct;53(10):1355-8

Graduate School of Pharmaceutical Sciences, Chiba University.

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October 2005

Antinociception, tolerance and withdrawal symptoms induced by 7-hydroxymitragynine, an alkaloid from the Thai medicinal herb Mitragyna speciosa.

Life Sci 2005 Nov 15;78(1):2-7. Epub 2005 Sep 15.

Laboratory of Pharmacolgy, Faculty of Pharmaceutical Sciences, Josai International University, 1 Gumyo, Togane, Chiba 283-8555, Japan.

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November 2005

Inhibitory effect of mitragynine, an analgesic alkaloid from Thai herbal medicine, on neurogenic contraction of the vas deferens.

Life Sci 2005 Nov 16;78(2):187-94. Epub 2005 Aug 16.

Department of Pharmacology, Faculty of Pharmaceutical Sciences, Josai International University, 1 Gumyo, Togane, Chiba 283-8555, Japan.

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November 2005

Potentially cytotoxic triterpenoids from the root bark of Siphonodon celastrineus Griff.

Arch Pharm Res 2005 May;28(5):546-9

Department of Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.

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May 2005

Suppressive effects of isorhynchophylline on 5-HT2A receptor function in the brain: behavioural and electrophysiological studies.

Eur J Pharmacol 2005 Jul;517(3):191-9

Division of Medicinal Pharmacology, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan.

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July 2005

Corymine potentiates NMDA-induced currents in Xenopus oocytes expressing NR1a/NR2B glutamate receptors.

J Pharmacol Sci 2005 May 12;98(1):58-65. Epub 2005 May 12.

Department of Pharmacology, Faculty of Medicine, Srinakharinwirot University, Bangkok 10110, Thailand.

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May 2005

Indole alkaloids of a Thai medicinal herb, Mitragyna speciosa, that has opioid agonistic effect in guinea-pig ileum.

Planta Med 2005 Mar;71(3):231-6

Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.

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March 2005

New type of trimeric and pentameric indole alkaloids from Psychotria rostrata.

Org Lett 2004 Aug;6(17):2945-8

Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 263-8522, Japan.

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August 2004

Chemistry and pharmacology of analgesic indole alkaloids from the rubiaceous plant, Mitragyna speciosa.

Chem Pharm Bull (Tokyo) 2004 Aug;52(8):916-28

Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.

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August 2004

Dimethylthioarsenicals as arsenic metabolites and their chemical preparations.

Chem Res Toxicol 2004 Jul;17(7):914-21

Department of Toxicology and Environmental Health, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260-8675, Japan.

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July 2004

A new 9-methoxyyohimbine-type indole alkaloid from Mitragyna africanus.

Chem Pharm Bull (Tokyo) 2004 Mar;52(3):359-61

Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.

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March 2004

Antinociceptive effect of 7-hydroxymitragynine in mice: Discovery of an orally active opioid analgesic from the Thai medicinal herb Mitragyna speciosa.

Life Sci 2004 Mar;74(17):2143-55

Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage, Chiba 263-8522, Japan.

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March 2004

Mesaconitine-induced relaxation in rat aorta: role of Na+/Ca2+ exchangers in endothelial cells.

Eur J Pharmacol 2004 Jan;483(2-3):139-46

Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 263-8522, Japan.

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January 2004

Biosynthesis of camptothecin. In silico and in vivo tracer study from [1-13C]glucose.

Plant Physiol 2004 Jan 4;134(1):161-70. Epub 2003 Dec 4.

Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

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January 2004

New oxindole alkaloids and iridoid from Carolina jasmine (Gelsemium sempervirens Ait. f.).

Chem Pharm Bull (Tokyo) 2003 Oct;51(10):1211-4

Graduate School of Pharmaceutical Sciences, Chiba University, Japan.

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October 2003

Ten new Lycopodium alkaloids having the lycopodane skeleton isolated from Lycopodium serratum Thunb.

Chem Pharm Bull (Tokyo) 2003 Oct;51(10):1163-9

Graduate School of Pharmaceutical Sciences, Chiba University, Japan.

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October 2003

Two oligostilbenes, cis- and trans-diptoindonesin B, from Dryobalanops oblongifolia.

Phytochemistry 2003 Aug;63(8):913-7

Natural Products Chemistry Group, Department of Chemistry, Institut Teknologi Bandung, Jalan Ganesha 10, 40132 Bandung, Indonesia.

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August 2003

Structure reinvestigation of gelsemoxonine, a constituent of Gelsemium elegans, reveals a novel, azetidine-containing indole alkaloid.

Org Lett 2003 Jun;5(12):2075-8

Graduate School of Pharmaceutical Sciences and Chemical Analysis Center, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

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June 2003

Metabolite profiling of alkaloids and strictosidine synthase activity in camptothecin producing plants.

Phytochemistry 2003 Feb;62(3):461-70

Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

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February 2003

Two new nor-triterpene glycosides from peruvian "Uña de Gato" (Uncaria tomentosa).

J Nat Prod 2003 Feb;66(2):320-3

Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

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February 2003