Hiromi Aoki-Ogata

Hiromi Aoki-Ogata

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Hiromi Aoki-Ogata

Hiromi Aoki-Ogata

Publications by authors named "Hiromi Aoki-Ogata"

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7Publications

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Mechanism of Darunavir (DRV)'s High Genetic Barrier to HIV-1 Resistance: A Key V32I Substitution in Protease Rarely Occurs, but Once It Occurs, It Predisposes HIV-1 To Develop DRV Resistance.

mBio 2018 03 6;9(2). Epub 2018 Mar 6.

Experimental Retrovirology Section, HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA

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http://dx.doi.org/10.1128/mBio.02425-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844992PMC
March 2018

C-5-Modified Tetrahydropyrano-Tetrahydofuran-Derived Protease Inhibitors (PIs) Exert Potent Inhibition of the Replication of HIV-1 Variants Highly Resistant to Various PIs, including Darunavir.

J Virol 2015 Nov 18;90(5):2180-94. Epub 2015 Nov 18.

Experimental Retrovirology Section, HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA Departments of Infectious Diseases and Hematology, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan Research Institute and Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo, Japan

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http://dx.doi.org/10.1128/JVI.01829-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810716PMC
November 2015

A conserved hydrogen-bonding network of P2 bis-tetrahydrofuran-containing HIV-1 protease inhibitors (PIs) with a protease active-site amino acid backbone aids in their activity against PI-resistant HIV.

Antimicrob Agents Chemother 2014 Jul 21;58(7):3679-88. Epub 2014 Apr 21.

Experimental Retrovirology Section, HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA Departments of Hematology and Infectious Diseases, Kumamoto University Graduate School of Biomedical Sciences, Kumamoto, Japan

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http://dx.doi.org/10.1128/AAC.00107-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4068604PMC
July 2014