Hiroko Wakimoto

Hiroko Wakimoto

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Hiroko Wakimoto

Hiroko Wakimoto

Publications by authors named "Hiroko Wakimoto"

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53Publications

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Yin Yang 1 Suppresses Dilated Cardiomyopathy and Cardiac Fibrosis Through Regulation of and .

Circ Res 2019 Oct 9;125(9):834-846. Epub 2019 Sep 9.

From the Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore (C.Y.T., J.X.W., P.S.C., H.T., D.L., W.C., J.J.).

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http://dx.doi.org/10.1161/CIRCRESAHA.119.314794DOI Listing
October 2019

Myc targeted CDK18 promotes ATR and homologous recombination to mediate PARP inhibitor resistance in glioblastoma.

Nat Commun 2019 07 2;10(1):2910. Epub 2019 Jul 2.

Molecular Neurosurgery Laboratory and the Brain Tumor Research Center and Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, 02114, MA, USA.

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http://dx.doi.org/10.1038/s41467-019-10993-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606647PMC
July 2019

Reduced expression of the ATP2A2 gene in vemurafenib-induced keratoacanthoma-like papules in a melanoma patient.

Int J Dermatol 2017 Feb 2;56(2):e33-e35. Epub 2016 Nov 2.

Department of Dermatology, Tokyo Medical University, Tokyo, Japan.

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http://dx.doi.org/10.1111/ijd.13430DOI Listing
February 2017

Integrative Analysis of PRKAG2 Cardiomyopathy iPS and Microtissue Models Identifies AMPK as a Regulator of Metabolism, Survival, and Fibrosis.

Cell Rep 2016 12;17(12):3292-3304

Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.11.066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5193246PMC
December 2016

Single-Cell Resolution of Temporal Gene Expression during Heart Development.

Dev Cell 2016 11 10;39(4):480-490. Epub 2016 Nov 10.

Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Cardiovascular Division, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2016.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5198784PMC
November 2016

AAV9 Delivery of shRNA to the Mouse Heart.

Curr Protoc Mol Biol 2016 07 1;115:23.16.1-23.16.9. Epub 2016 Jul 1.

Department of Genetics, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1002/cpmb.9DOI Listing
July 2016

Molecular profiling of dilated cardiomyopathy that progresses to heart failure.

JCI Insight 2016 May;1(6)

Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA; Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA; Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1172/jci.insight.86898DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882118PMC
May 2016

A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice.

Science 2016 Feb;351(6273):617-21

Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.

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http://dx.doi.org/10.1126/science.aad3456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784435PMC
February 2016

Mouse Model of Human Congenital Heart Disease: Progressive Atrioventricular Block Induced by a Heterozygous Nkx2-5 Homeodomain Missense Mutation.

Circ Arrhythm Electrophysiol 2015 Oct 30;8(5):1255-64. Epub 2015 Jul 30.

From the Department of Physiology and Functional Genomics, College of Medicine, University of Florida, Gainesville (R.C., H.A., M.M., Y.T., M.N., H.K.); Department of Pediatrics, Oregon Health Science School, Portland (M.S.); Department of Genetics, Harvard Medical School, Boston, MA (H.W.); Department of Pediatrics, Herma Heart Center, Medical College of Wisconsin, Milwaukee (D.W.B.); and Institute of Genetic Medicine, Newcastle University, Newcastle, United Kingdom (R.H.A.).

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http://dx.doi.org/10.1161/CIRCEP.115.002720DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618020PMC
October 2015

Cardiac myosin binding protein C regulates postnatal myocyte cytokinesis.

Proc Natl Acad Sci U S A 2015 Jul 7;112(29):9046-51. Epub 2015 Jul 7.

Department of Genetics, Harvard Medical School, Boston, MA 02115; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1511004112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517252PMC
July 2015

Isolation of single-stranded DNA.

Curr Protoc Mol Biol 2014 Jul 1;107:2.15.1-9. Epub 2014 Jul 1.

Department of Genetics, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1002/0471142727.mb0215s107DOI Listing
July 2014

Allele-specific silencing of mutant Myh6 transcripts in mice suppresses hypertrophic cardiomyopathy.

Science 2013 Oct;342(6154):111-4

Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/science.1236921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100553PMC
October 2013

Slow progressive conduction and contraction defects in loss of Nkx2-5 mice after cardiomyocyte terminal differentiation.

Lab Invest 2009 Sep 22;89(9):983-93. Epub 2009 Jun 22.

Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, FL 32610-0274, USA.

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http://dx.doi.org/10.1038/labinvest.2009.59DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2733927PMC
September 2009

Pheochromocytoma-induced cardiomyopathy is modulated by the synergistic effects of cell-secreted factors.

Circ Heart Fail 2009 Mar 10;2(2):121-8. Epub 2009 Feb 10.

Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, E25-442, Cambridge, MA 02139, USA.

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https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.108
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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.108.813261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769512PMC
March 2009

Aberrant activation of AMP-activated protein kinase remodels metabolic network in favor of cardiac glycogen storage.

J Clin Invest 2007 May 12;117(5):1432-9. Epub 2007 Apr 12.

NMR Laboratory for Physiological Chemistry, Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA.

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http://www.jci.org/cgi/doi/10.1172/JCI30658
Publisher Site
http://dx.doi.org/10.1172/JCI30658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1847536PMC
May 2007

Absence of Msx2 does not affect cardiac conduction or rescue conduction defects associated with Nkx2-5 mutation.

J Cardiovasc Electrophysiol 2005 Jan;16(1):82-5

Department of Cardiology, Children's Hospital, Boston, Massachusetts 02139, USA.

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http://dx.doi.org/10.1046/j.1540-8167.2005.04365.xDOI Listing
January 2005

Changes in body surface potential distributions induced by isoproterenol and Na channel blockers in patients with the Brugada syndrome.

Int J Cardiol 2004 Jun;95(2-3):261-8

Department of Human Ontogeny and Childhood Development/Pediatrics, Graduate School of Medicine, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.

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http://dx.doi.org/10.1016/j.ijcard.2003.05.025DOI Listing
June 2004

Cardiac electrophysiological phenotypes in postnatal expression of Nkx2.5 transgenic mice.

Genesis 2003 Nov;37(3):144-50

Department of Cardiology, Children's Hospital, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1002/gene.10236DOI Listing
November 2003

Relationships of circulating nitrite/nitrate levels to severity and multiple organ dysfunction syndrome in systemic inflammatory response syndrome.

Shock 2003 Apr;19(4):305-9

Department of Critical Care Medicine, Tokyo Medical and Dental University Graduate School, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.

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http://dx.doi.org/10.1097/00024382-200304000-00002DOI Listing
April 2003

Nkx2.5 homeoprotein regulates expression of gap junction protein connexin 43 and sarcomere organization in postnatal cardiomyocytes.

J Mol Cell Cardiol 2003 Mar;35(3):243-56

Department of Medicine, Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, SL201, Boston, MA 02215, USA.

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http://dx.doi.org/10.1016/s0022-2828(03)00002-6DOI Listing
March 2003

Characterization of cardiac conduction system abnormalities in mice with targeted disruption of Six5 gene.

J Interv Card Electrophysiol 2002 Oct;7(2):127-35

Department of Cardiology, Children's Hospital, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1023/a:1020881520353DOI Listing
October 2002

Developmentally modulated cardiac conduction failure in transgenic mice with fetal or postnatal overexpression of DNA nonbinding mutant Nkx2.5.

J Cardiovasc Electrophysiol 2002 Jul;13(7):682-8

Department of Cardiology, Children's Hospital, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1046/j.1540-8167.2002.00682.xDOI Listing
July 2002