Publications

Prdm16 is crucial for progression of the multipolar phase during neural differentiation of the developing neocortex.
Development 2017 Feb 19;144(3):385-399. Epub 2016 Dec 19.
Laboratory of Neural Differentiation, Graduate School of Brain Science, Doshisha University, Kyoto 6190225, Japan



Crystal structure of the anion exchanger domain of human erythrocyte band 3.
Science 2015 Nov;350(6261):680-4
Japan Science and Technology Agency (JST), Exploratory Research for Advanced Technology (ERATO) Human Receptor Crystallography Project, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan. JST, Research Acceleration Program, Membrane Protein Crystallography Project, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan. Department of Cell Biology, Kyoto University Faculty of Medicine, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan. Division of Molecular Biosciences, Membrane Protein Crystallography group, Imperial College London, London SW7 2AZ, UK. Membrane Protein Laboratory, Diamond Light Source, Harwell Science and Innovation Campus, Didcot, Chilton, Oxfordshire OX11 0DE, UK. Research Complex at Harwell Rutherford, Appleton Laboratory, Harwell Oxford, Didcot, Oxfordshire OX11 0FA, UK. Platform for Drug Discovery, Informatics, and Structural Life Science, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan.

Analysis of the subcellular localization of the human histone methyltransferase SETDB1.
Biochem Biophys Res Commun 2015 Oct 18;465(4):725-31. Epub 2015 Aug 18.
Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan. Electronic address:





Chemical corrector treatment ameliorates increased seizure susceptibility in a mouse model of familial epilepsy.
Nat Med 2015 Jan 8;21(1):19-26. Epub 2014 Dec 8.
1] Division of Membrane Physiology, Department of Cell Physiology, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki, Japan. [2] Department of Physiological Sciences, School of Life Science, The Graduate University for Advanced Studies (SOKENDAI), Okazaki, Japan.


Immunostaining of oxidized DJ-1 in human and mouse brains.
J Neuropathol Exp Neurol 2014 Jul;73(7):714-28
From the Systems Life Sciences (YS, KH, YM, NN) and Neuropathology (TM, YI), Department of Medical Life Systems, Faculty of Medical and Life Sciences, Doshisha University, Kyotanabe, Kyoto; Department of Neuropathology, Tokyo Metropolitan Institute of Gerontology (HH, SM); Laboratory of Systems Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo (OK-A, HI, TH); and Institute of Immunology Co Ltd (OK-A), Tokyo; Health Research Institute, National Institute of Advanced Industrial Science and Technology, Ikeda, Osaka (YY, EN); and Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-ku, Sapporo (KT-N, HA), Japan.



A mesodermal factor, T, specifies mouse germ cell fate by directly activating germline determinants.
Dev Cell 2013 Dec;27(5):516-29
Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan; Exploratory Research for Advanced Technology, Japan Science and Technology Agency, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan; Center for iPS Cell Research and Application, Kyoto University, 53 Kawahara-cho, Shogoin Yoshida, Sakyo-ku, Kyoto 606-8507, Japan; Institute for Integrated Cell-Material Sciences, Kyoto University, Yoshida-Ushinomiya-cho, Sakyo-ku, Kyoto 606-8501, Japan. Electronic address:


Novel role of copper transport protein antioxidant-1 in neointimal formation after vascular injury.
Arterioscler Thromb Vasc Biol 2013 Apr 24;33(4):805-13. Epub 2013 Jan 24.
Department of Medicine, Center for Cardiovascular Research, University of Illinois at Chicago, 835 S. Wolcott, M/C868, E403 MSB, Chicago, IL 60612, USA.

Inhibition of DNA damage-induced apoptosis through Cdc7-mediated stabilization of Tob.
J Biol Chem 2012 Nov 12;287(48):40256-65. Epub 2012 Oct 12.
Department of Cancer Biology, Division of Oncology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Tokyo 108-8639, Japan.

G-protein-coupled receptor inactivation by an allosteric inverse-agonist antibody.
Nature 2012 Jan 29;482(7384):237-40. Epub 2012 Jan 29.
Iwata Human Receptor Crystallography Project, ERATO, Japan Science and Technology Agency, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.

A method of generating antibodies against exogenously administered self-antigen by manipulating CD4+CD25+ regulatory T cells.
J Immunol Methods 2011 Jun 3;369(1-2):108-14. Epub 2011 May 3.
Department of Molecular Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Meguro, Tokyo 153-8904, Japan.


Elevation of oxidized DJ-1 in the brain and erythrocytes of Parkinson disease model animals.
Neurosci Lett 2010 Oct 11;483(3):201-5. Epub 2010 Aug 11.
Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Ikeda, Osaka, Japan.


Single chain variable fragment against nicastrin inhibits the gamma-secretase activity.
J Biol Chem 2009 Oct 14;284(41):27838-47. Epub 2009 Aug 14.
Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.


Mobile DHHC palmitoylating enzyme mediates activity-sensitive synaptic targeting of PSD-95.
J Cell Biol 2009 Jul;186(1):147-60
Division of Membrane Physiology, Department of Cell Physiology, National Institute for Physiological Sciences, Okazaki, Aichi, Japan.

Expression of liver X receptor alpha and lipid metabolism in granulocyte-macrophage colony-stimulating factor-induced human monocyte-derived macrophage.
Pathol Int 2009 Mar;59(3):152-60
Division of Cellular and Molecular Pathology, Department of Cellular Function, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.



Human homolog of NOTUM, overexpressed in hepatocellular carcinoma, is regulated transcriptionally by beta-catenin/TCF.
Cancer Sci 2008 Jun 21;99(6):1139-46. Epub 2008 Apr 21.
Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1, Komaba, Meguro-ku, Tokyo 153-8904, Japan.

Lipopolysaccharide induced expression of pentraxin 3 in human neutrophils and monocyte-derived macrophages.
Cell Immunol 2007 Aug 28;248(2):86-94. Epub 2007 Nov 28.
Division of Cellular and Molecular Pathology, Department of Cellular Function, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi 1-757, Chuou-ku, Niigata 951-8510, Japan.

Expression of liver X receptor alpha in rat fetal tissues at different developmental stages.
J Histochem Cytochem 2007 Jun 6;55(6):641-9. Epub 2007 Mar 6.
Division of Cellular and Molecular Pathology, Department of Cellular Function, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi-dori 1-757, 951-8510, Niigata, Japan.




A simple hybridoma screening method for high-affinity monoclonal antibodies using the signal ratio obtained from time-resolved fluorescence assay.
Anal Biochem 2006 Apr 17;351(2):219-28. Epub 2006 Jan 17.
Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo, 4-6-1 Komaba, Meguro, Tokyo 153-8904, Japan.



Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9.
Genes Dev 2005 Apr 17;19(7):815-26. Epub 2005 Mar 17.
Experimental Research Center for Infectious Diseases, Institute for Virus Research, Kyoto University, Sakyo-ku, Kyoto 606-8507, Japan.

Expression of the LXRalpha protein in human atherosclerotic lesions.
Arterioscler Thromb Vasc Biol 2005 Mar 29;25(3):622-7. Epub 2004 Dec 29.
Department of Systems Biology and Medicine, Research Center for Advanced Science and Technology, the University of Tokyo, Japan.

Overexpression of the aldo-keto reductase family protein AKR1B10 is highly correlated with smokers' non-small cell lung carcinomas.
Clin Cancer Res 2005 Mar;11(5):1776-85
Genome Science Division and Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology, Graduate School of Medicine, University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, Japan.


Expression and localization of P1 promoter-driven hepatocyte nuclear factor-4α (HNF4α) isoforms in human and rats.
Nucl Recept 2003 8;1. Epub 2003 Aug 8.
Department of Cellular Function, Division of Cellular and Molecular Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

A novel method for viral display of ER membrane proteins on budded baculovirus.
Biochem Biophys Res Commun 2003 Aug;308(1):191-6
Department of Molecular Biology, Research Center for Advanced Science and Technology, The University of Tokyo, #35 4-6-1 Komaba, Meguro, Tokyo 153-8904, Japan.



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