Hiroki Tsumoto

Hiroki Tsumoto

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Hiroki Tsumoto

Hiroki Tsumoto

Publications by authors named "Hiroki Tsumoto"

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Crystal structures of fukutin-related protein (FKRP), a ribitol-phosphate transferase related to muscular dystrophy.

Nat Commun 2020 Jan 16;11(1):303. Epub 2020 Jan 16.

Structural Biology Research Center, Institute of Materials Structure Science, High Energy Accelerator Research Organization, Tsukuba, Ibaraki, 305-0801, Japan.

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http://dx.doi.org/10.1038/s41467-019-14220-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6965139PMC
January 2020

Fumarate accumulation involved in renal diabetic fibrosis in Goto-Kakizaki rats.

Arch Biochem Biophys 2019 Dec 5;678:108167. Epub 2019 Nov 5.

Research Team for Mechanism of Aging, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo, 173-0015, Japan.

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http://dx.doi.org/10.1016/j.abb.2019.108167DOI Listing
December 2019

Prevention of calpain-dependent degradation of STK38 by MEKK2-mediated phosphorylation.

Sci Rep 2019 Nov 5;9(1):16010. Epub 2019 Nov 5.

Laboratory of Molecular Radiology, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

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http://dx.doi.org/10.1038/s41598-019-52435-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831656PMC
November 2019

Age-associated proteomic alterations in human aortic media.

Geriatr Gerontol Int 2019 Oct 21;19(10):1054-1062. Epub 2019 Aug 21.

Department of Molecular Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

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http://dx.doi.org/10.1111/ggi.13757DOI Listing
October 2019

Proteomic study on neurite responses to oxidative stress: search for differentially expressed proteins in isolated neurites of N1E-115 cells.

J Clin Biochem Nutr 2019 Jan 11;64(1):36-44. Epub 2018 Aug 11.

Research Team for Mechanism of Aging, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakaecho, Itabashi-ku, Tokyo 173-0015, Japan.

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http://dx.doi.org/10.3164/jcbn.18-31DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348415PMC
January 2019

Contribution of the exosome-associated form of secreted endoplasmic reticulum aminopeptidase 1 to exosome-mediated macrophage activation.

Biochim Biophys Acta Mol Cell Res 2018 Jun 19;1865(6):874-888. Epub 2018 Mar 19.

Faculty of Pharmaceutical Sciences, Teikyo-Heisei University, Nakano, Tokyo 164-8530, Japan.

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http://dx.doi.org/10.1016/j.bbamcr.2018.03.009DOI Listing
June 2018

Characteristic glycopeptides associated with extreme human longevity identified through plasma glycoproteomics.

Biochim Biophys Acta Gen Subj 2018 06 24;1862(6):1462-1471. Epub 2018 Mar 24.

Research Team for Mechanism of Aging, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bbagen.2018.03.025DOI Listing
June 2018

Cell endogenous activities of fukutin and FKRP coexist with the ribitol xylosyltransferase, TMEM5.

Biochem Biophys Res Commun 2018 03;497(4):1025-1030

Division of Neurology/Molecular Brain Science, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-chou, Chuo-ku, Kobe 650-0017, Japan; Department of Neurology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2018.02.162DOI Listing
March 2018

Mitochondrial intermediate peptidase is a novel regulator of sirtuin-3 activation by caloric restriction.

FEBS Lett 2017 12 28;591(24):4067-4073. Epub 2017 Nov 28.

Laboratory of Molecular Pathology and Metabolic Disease, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan.

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http://dx.doi.org/10.1002/1873-3468.12914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767765PMC
December 2017

Quantitative analysis of O-GlcNAcylation in combination with isobaric tag labeling and chemoenzymatic enrichment.

Bioorg Med Chem Lett 2017 11 4;27(22):5022-5026. Epub 2017 Oct 4.

Research Team for Mechanism of Aging, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2017.10.005DOI Listing
November 2017

Potent mechanism-based sirtuin-2-selective inhibition by an -generated occupant of the substrate-binding site, "selectivity pocket" and NAD-binding site.

Chem Sci 2017 Sep 21;8(9):6400-6408. Epub 2017 Jul 21.

Graduate School of Medical Science , Kyoto Prefectural University of Medicine , 1-5 Shimogamohangi-cho, Sakyo-ku , Kyoto 606-0823 , Japan . Email:

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http://dx.doi.org/10.1039/c7sc02738aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628579PMC
September 2017

TLN-58, an Additional hCAP18 Processing Form, Found in the Lesion Vesicle of Palmoplantar Pustulosis in the Skin.

J Invest Dermatol 2017 02 19;137(2):322-331. Epub 2016 Oct 19.

Department of Dermatology, Ehime University Graduate School of Medicine, Ehime, Japan.

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http://dx.doi.org/10.1016/j.jid.2016.07.044DOI Listing
February 2017

Differentiation of Sialyl Linkage Isomers by One-Pot Sialic Acid Derivatization for Mass Spectrometry-Based Glycan Profiling.

Anal Chem 2017 02 8;89(4):2353-2360. Epub 2017 Feb 8.

Koichi Tanaka Mass Spectrometry Research Laboratory, Shimadzu Corporation , 1, Nishinokyo-Kuwabaracho, Nakagyo-ku, Kyoto 604-8511, Japan.

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http://dx.doi.org/10.1021/acs.analchem.6b04150DOI Listing
February 2017

Excess APP O-glycosylation by GalNAc-T6 decreases Aβ production.

J Biochem 2017 Jan 19;161(1):99-111. Epub 2016 Oct 19.

Molecular Glycobiology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, 35-2 Sakaecho, Itabashi-ku, Tokyo 173-0015, Japan

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http://dx.doi.org/10.1093/jb/mvw056DOI Listing
January 2017

POMGNT1 Is Glycosylated by Mucin-Type O-Glycans.

Biol Pharm Bull 2015 ;38(9):1389-94

Molecular Glycobiology, Research Team for Mechanism of Aging, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology.

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http://dx.doi.org/10.1248/bpb.b15-00415DOI Listing
June 2016

Heat Resistant Characteristics of Major Royal Jelly Protein 1 (MRJP1) Oligomer.

PLoS One 2015 28;10(5):e0119169. Epub 2015 May 28.

Research Team for Mechanism of Aging, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0119169PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447272PMC
April 2016

Identification of SNAIL1 Peptide-Based Irreversible Lysine-Specific Demethylase 1-Selective Inactivators.

J Med Chem 2016 Feb 4;59(4):1531-44. Epub 2016 Jan 4.

Graduate School of Medical Science, Kyoto Prefectural University of Medicine , 1-5 Shimogamohangi-Cho, Sakyo-Ku, Kyoto, 606-0823, Japan.

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http://dx.doi.org/10.1021/acs.jmedchem.5b01323DOI Listing
February 2016

Enrichment of O-GlcNAc-modified peptides using novel thiol-alkyne and thiol-disulfide exchange.

Bioorg Med Chem Lett 2015 Jul 30;25(13):2645-9. Epub 2015 Apr 30.

Research Team for Mechanism of Aging, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2015.04.082DOI Listing
July 2015

Integrin β4 and vinculin contained in exosomes are potential markers for progression of prostate cancer associated with taxane-resistance.

Int J Oncol 2015 Jul 18;47(1):384-90. Epub 2015 May 18.

Research Team for Mechanism of Aging, Tokyo Metropolitan Institute of Gerontology, Tokyo 173-0015, Japan.

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https://www.spandidos-publications.com/10.3892/ijo.2015.3011
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http://dx.doi.org/10.3892/ijo.2015.3011DOI Listing
July 2015

Histone H3 peptide based LSD1-selective inhibitors.

Bioorg Med Chem Lett 2015 May 20;25(9):1925-8. Epub 2015 Mar 20.

Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 1-5 Shimogamohangi-cho, Sakyo-ku, Kyoto 606-0823, Japan; CREST, Japan Science and Technology Agency (JST), 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2015.03.030DOI Listing
May 2015

Lysine-specific demethylase 1-selective inactivators: protein-targeted drug delivery mechanism.

Angew Chem Int Ed Engl 2013 Aug 3;52(33):8620-4. Epub 2013 Jul 3.

Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 13 Nishitakatsukasa-cho, Taishogun Kita-ku, Kyoto 603-8334, Japan.

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http://dx.doi.org/10.1002/anie.201303999DOI Listing
August 2013

Photoinduced upregulation of calcitonin gene-related peptide in A549 cells through HNO release from a hydrophilic photocontrollable HNO donor.

Chem Pharm Bull (Tokyo) 2012 ;60(8):1055-62

Department of Organic and Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Nagoya, Aichi 467-8603, Japan.

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http://dx.doi.org/10.1248/cpb.c12-00348DOI Listing
December 2012

Proteomic analysis of S-nitrosylation induced by 1-methyl-4-phenylpyridinium (MPP+).

Proteome Sci 2012 Dec 29;10(1):74. Epub 2012 Dec 29.

Department of Pharmacology, Nara Medical University School of Medicine, 840 Shijo-cho, Kashihara, Nar, 634-8521, Japan.

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http://dx.doi.org/10.1186/1477-5956-10-74DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576269PMC
December 2012

Rapid discovery of highly potent and selective inhibitors of histone deacetylase 8 using click chemistry to generate candidate libraries.

J Med Chem 2012 Nov 12;55(22):9562-75. Epub 2012 Nov 12.

Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 13 Taishogun Nishitakatsukasa-Cho, Kita-ku, Kyoto 403-8334, Japan.

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http://dx.doi.org/10.1021/jm300837yDOI Listing
November 2012

Short-chain fatty acid receptor GPR41-mediated activation of sympathetic neurons involves synapsin 2b phosphorylation.

FEBS Lett 2012 May 21;586(10):1547-54. Epub 2012 Apr 21.

Department of Genomic Drug Discovery Science, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo-ku, Kyoto, Japan.

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http://dx.doi.org/10.1016/j.febslet.2012.04.021DOI Listing
May 2012

Peroxynitrite generation from a NO-releasing nitrobenzene derivative in response to photoirradiation.

Chem Commun (Camb) 2011 Jun 6;47(22):6449-51. Epub 2011 May 6.

Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Nagoya, Aichi 467-8603, Japan.

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http://dx.doi.org/10.1039/c1cc11681aDOI Listing
June 2011

Development of a DNA-binding TEMPO derivative for evaluation of nuclear oxidative stress and its application in living cells.

Free Radic Biol Med 2010 Dec 18;49(11):1792-7. Epub 2010 Sep 18.

Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Aichi, Japan.

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http://dx.doi.org/10.1016/j.freeradbiomed.2010.09.009DOI Listing
December 2010

An unexpected example of protein-templated click chemistry.

Angew Chem Int Ed Engl 2010 Sep;49(38):6817-20

Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan.

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http://dx.doi.org/10.1002/anie.201002205DOI Listing
September 2010

Identification and determination of urinary acetylpolyamines in cancer patients by electrospray ionization and time-of-flight mass spectrometry.

Anal Biochem 2010 Jun 21;401(1):22-9. Epub 2010 Feb 21.

Research Institute of Pharmaceutical Sciences, Musashino University, 1-1-20 Shinmachi, Nishitokyo, Tokyo 202-8585, Japan.

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http://dx.doi.org/10.1016/j.ab.2010.02.022DOI Listing
June 2010

Alternative photoinduced release of HNO or NO from an acyl nitroso compound, depending on environmental polarity.

Chem Commun (Camb) 2010 Jun 14;46(21):3788-90. Epub 2010 Apr 14.

Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan.

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http://xlink.rsc.org/?DOI=c001502d
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http://dx.doi.org/10.1039/c001502dDOI Listing
June 2010

Efficient identification and quantification of peptides containing nitrotyrosine by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry after derivatization.

Chem Pharm Bull (Tokyo) 2010 Apr;58(4):488-94

Research Institute of Pharmaceutical Sciences, Musashino University, Tokyo, Japan.

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http://dx.doi.org/10.1248/cpb.58.488DOI Listing
April 2010

Multiple bond-conjugated photoinduced nitric oxide releaser working with two-photon excitation.

Bioorg Med Chem Lett 2010 Jan 30;20(1):302-5. Epub 2009 Oct 30.

Graduate School of Pharmaceutical Science, Nagoya City University, 3-1 Tanabe-dori Mizuho-ku, Nagoya, Aichi 467-8603, Japan.

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http://dx.doi.org/10.1016/j.bmcl.2009.10.120DOI Listing
January 2010

Identification of cell-active lysine specific demethylase 1-selective inhibitors.

J Am Chem Soc 2009 Dec;131(48):17536-7

Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan.

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http://pubs.acs.org/doi/abs/10.1021/ja907055q
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http://dx.doi.org/10.1021/ja907055qDOI Listing
December 2009

Identification of a cell-active non-peptide sirtuin inhibitor containing N-thioacetyl lysine.

Bioorg Med Chem Lett 2009 Oct 12;19(19):5670-2. Epub 2009 Aug 12.

Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan.

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http://dx.doi.org/10.1016/j.bmcl.2009.08.028DOI Listing
October 2009

Design, synthesis, enzyme inhibition, and tumor cell growth inhibition of 2-anilinobenzamide derivatives as SIRT1 inhibitors.

Bioorg Med Chem 2009 Aug 7;17(16):5900-5. Epub 2009 Jul 7.

Nagoya City University, Tanabe-dori, Mizuho-ku, Aichi, Japan.

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http://dx.doi.org/10.1016/j.bmc.2009.07.001DOI Listing
August 2009

Photoinduced nitric oxide release from a hindered nitrobenzene derivative by two-photon excitation.

J Am Chem Soc 2009 Jun;131(22):7488-9

Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori Mizuho-ku, Nagoya, Aichi 467-8603, Japan.

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http://dx.doi.org/10.1021/ja8093668DOI Listing
June 2009

Inhibition of human sirtuins by in situ generation of an acetylated lysine-ADP-ribose conjugate.

J Am Chem Soc 2009 May;131(20):6989-96

Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan.

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http://dx.doi.org/10.1021/ja807083yDOI Listing
May 2009

Design, synthesis, and biological activity of boronic acid-based histone deacetylase inhibitors.

J Med Chem 2009 May;52(9):2909-22

Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan.

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http://dx.doi.org/10.1021/jm900125mDOI Listing
May 2009

Chemical derivatization of peptides containing phosphorylated serine/threonine for efficient ionization and quantification in matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.

Rapid Commun Mass Spectrom 2008 Apr;22(7):965-72

Research Institute of Pharmaceutical Sciences, Musashino University, Shinmachi, Nishitokyo-shi, Tokyo 202-8585, Japan.

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http://dx.doi.org/10.1002/rcm.3451DOI Listing
April 2008

Efficient identification and quantification of proteins using isotope-coded 1-(6-methylnicotinoyloxy)succinimides by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.

Rapid Commun Mass Spectrom 2007 ;21(23):3815-24

Research Institute of Pharmaceutical Sciences, Musashino University, Shinmachi Nishitokyo-shi, Tokyo 202-8585, Japan.

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http://doi.wiley.com/10.1002/rcm.3279
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http://dx.doi.org/10.1002/rcm.3279DOI Listing
January 2008

Preparation of C60-based active esters and coupling of C60 moiety to amines or alcohols.

Bioorg Med Chem Lett 2008 Jan 22;18(2):657-60. Epub 2007 Nov 22.

Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabedori, Nagoya, Aichi 467-8603, Japan.

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http://linkinghub.elsevier.com/retrieve/pii/S0960894X0701375
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http://dx.doi.org/10.1016/j.bmcl.2007.11.065DOI Listing
January 2008

Electrospray ionization and time-of-flight mass spectrometric method for simultaneous determination of spermidine and spermine.

Biol Pharm Bull 2007 Oct;30(10):1943-6

Research Institute of Pharmaceutical Sciences, Musashino University, Tokyo, Japan.

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http://dx.doi.org/10.1248/bpb.30.1943DOI Listing
October 2007

Preparation of deuterated methyl and dimethyl substituted nicotinoylating agents for derivatization of the N-terminal of protein.

Chem Pharm Bull (Tokyo) 2003 Dec;51(12):1399-401

Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan.

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http://dx.doi.org/10.1248/cpb.51.1399DOI Listing
December 2003