Publications

Differing contributions of the first and second pharyngeal arches to tympanic membrane formation in the mouse and chick.
Development 2017 Aug 14. Epub 2017 Aug 14.
Section of Molecular Craniofacial Embryology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan.


Postotic and preotic cranial neural crest cells differently contribute to thyroid development.
Dev Biol 2016 Jan 23;409(1):72-83. Epub 2015 Oct 23.
Department of Pediatric Cardiology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan; Division of Cardiovascular Development and Differentiation, Medical Research Institute, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan. Electronic address:


Autonomy and Non-autonomy of Angiogenic Cell Movements Revealed by Experiment-Driven Mathematical Modeling.
Cell Rep 2015 Dec 19;13(9):1814-27. Epub 2015 Nov 19.
Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, the University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), Chiyoda-ku, Tokyo 102-0076, Japan; Institute for Biology and Mathematics of Dynamical Cell Processes (iBMath), the University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8914, Japan.

Distinct effects of Hoxa2 overexpression in cranial neural crest populations reveal that the mammalian hyomandibular-ceratohyal boundary maps within the styloid process.
Dev Biol 2015 Jun 16;402(2):162-74. Epub 2015 Apr 16.
Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), Chiyoda-ku, Tokyo 102-0076, Japan; Institute for Biology and Mathematics of Dynamical Cell Processes (iBMath), The University of Tokyo, 3-8-1 Komaba, Tokyo 153-8914, Japan. Electronic address:


Developmental genetic bases behind the independent origin of the tympanic membrane in mammals and diapsids.
Nat Commun 2015 Apr 22;6:6853. Epub 2015 Apr 22.
1] Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan [2] Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), Chiyoda-ku, Tokyo 102-0076, Japan [3] Institute for Biology and Mathematics of Dynamical Cell Processes (iBMath), The University of Tokyo, 3-8-1 Komaba, Tokyo 153-8914, Japan.




SIRT3 positively regulates the expression of folliculogenesis- and luteinization-related genes and progesterone secretion by manipulating oxidative stress in human luteinized granulosa cells.
Endocrinology 2014 Aug 30;155(8):3079-87. Epub 2014 May 30.
Department of Obstetrics and Gynecology (H.F., O.W.-H., M.H., A.Sa., A.Sh., Y.M., W.I., K.Ko., K.O., K.Ka. Y.O., T.F.) and the University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan; Department of Physiological Chemistry and Metabolism (Y.K., W.I., H.K.), Graduate School of Medicine, the University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan; Department of Obstetrics and Gynecology (H.O., T.Y.), National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjyuku-ku, Tokyo 162-8655, Japan.

Myocardium-derived angiopoietin-1 is essential for coronary vein formation in the developing heart.
Nat Commun 2014 Jul 29;5:4552. Epub 2014 Jul 29.
1] Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan [2] Core Research for Evolutional Science and Technology (CREST), Japan Science Technology Agency, 4-1-8, Honcho, Kawaguchi, Saitama 332-0012, Japan.

LST8 level controls basal p70 S6 kinase and Akt phosphorylations, and mTORC1 and mTORC2 negatively regulate each other by competing for association with LST8.
Obes Res Clin Pract 2012 Jul-Sep;6(3):e175-262
Department of Medical Science, Graduate School of Medicine, University of Hiroshima, 1-2-3 Kasumi, Minami-ku, Hiroshima City 734-8553, Hiroshima, Japan. Electronic

Endothelin regulates neural crest deployment and fate to form great vessels through Dlx5/Dlx6-independent mechanisms.
Mech Dev 2013 Nov-Dec;130(11-12):553-66. Epub 2013 Aug 8.
Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.





Preotic neural crest cells contribute to coronary artery smooth muscle involving endothelin signalling.
Nat Commun 2012 ;3:1267
Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.


Valsartan, independently of AT1 receptor or PPARγ, suppresses LPS-induced macrophage activation and improves insulin resistance in cocultured adipocytes.
Am J Physiol Endocrinol Metab 2012 Feb 1;302(3):E286-96. Epub 2011 Nov 1.
Department of Biomedical Chemistry, Division of Molecular Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.


Chemical understanding of carbide cluster metallofullerenes: a case study on Sc2C2@C2v(5)-C80 with complete X-ray crystallographic characterizations.
J Am Chem Soc 2012 Feb 2;134(6):3139-44. Epub 2012 Feb 2.
Life Science Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba, Ibaraki 305-8577, Japan.

Angiogenic morphogenesis driven by dynamic and heterogeneous collective endothelial cell movement.
Development 2011 Nov 28;138(21):4763-76. Epub 2011 Sep 28.
Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.


4F2hc stabilizes GLUT1 protein and increases glucose transport activity.
Am J Physiol Cell Physiol 2011 May 26;300(5):C1047-54. Epub 2011 Jan 26.
Dept. of Medical Science, Graduate School of Medicine, University of Hiroshima, 1-2-3 Kasumi, Minami-ku, Hiroshima City, Hiroshima, Japan.

Calpain-6, a microtubule-stabilizing protein, regulates Rac1 activity and cell motility through interaction with GEF-H1.
J Cell Sci 2011 Apr 15;124(Pt 8):1214-23. Epub 2011 Mar 15.
Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.



Endothelin receptor type A expression defines a distinct cardiac subdomain within the heart field and is later implicated in chamber myocardium formation.
Development 2010 Nov 7;137(22):3823-33. Epub 2010 Oct 7.
Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.


Macrophage foam cell formation is augmented in serum from patients with diabetic angiopathy.
Diabetes Res Clin Pract 2010 Jan 24;87(1):57-63. Epub 2009 Nov 24.
Department of Medical Chemistry, Division of Molecular Medical Science, Graduate School of Biomedical Science, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima City, Hiroshima, Japan.

Donepezil improves cognitive function in mice by increasing the production of insulin-like growth factor-I in the hippocampus.
J Pharmacol Exp Ther 2009 Jul 24;330(1):2-12. Epub 2009 Mar 24.
Department of Anesthesiology and Medical Crisis Management, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan.



Neuronal system-dependent facilitation of tumor angiogenesis and tumor growth by calcitonin gene-related peptide.
Proc Natl Acad Sci U S A 2008 Sep 29;105(36):13550-5. Epub 2008 Aug 29.
Departments of Pharmacology and Anesthesiology, Kitasato University School of Medicine, Kanagawa 228-8555, Japan.

Effect of topical application of raspberry ketone on dermal production of insulin-like growth factor-I in mice and on hair growth and skin elasticity in humans.
Growth Horm IGF Res 2008 Aug 5;18(4):335-44. Epub 2008 Mar 5.
Department of Translational Medical Science Research, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan.


Multiple renal cysts, urinary concentration defects, and pulmonary emphysematous changes in mice lacking TAZ.
Am J Physiol Renal Physiol 2008 Mar 2;294(3):F542-53. Epub 2008 Jan 2.
Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

Recombinase-mediated cassette exchange reveals the selective use of Gq/G11-dependent and -independent endothelin 1/endothelin type A receptor signaling in pharyngeal arch development.
Development 2008 Feb 16;135(4):755-65. Epub 2008 Jan 16.
Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

Regulation of gut-derived resistin-like molecule beta expression by nutrients.
Diabetes Res Clin Pract 2008 Jan 23;79(1):2-10. Epub 2007 Oct 23.
Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

Maintenance of genomic methylation patterns during preimplantation development requires the somatic form of DNA methyltransferase 1.
Dev Biol 2008 Jan 30;313(1):335-46. Epub 2007 Oct 30.
Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.



Administration of capsaicin and isoflavone promotes hair growth by increasing insulin-like growth factor-I production in mice and in humans with alopecia.
Growth Horm IGF Res 2007 Oct 13;17(5):408-15. Epub 2007 Jun 13.
Department of Translational Medical Science Research, Nagoya City University, Graduate School of Medical Sciences, Kawasumi 1, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan.

Beta-defensin overexpression induces progressive muscle degeneration in mice.
Am J Physiol Cell Physiol 2007 Jun 10;292(6):C2141-9. Epub 2007 Jan 10.
Dept. of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.


Role of hepatic AMPK activation in glucose metabolism and dexamethasone-induced regulation of AMPK expression.
Diabetes Res Clin Pract 2006 Aug 28;73(2):135-42. Epub 2006 Feb 28.
Department of Sports Medicine, Graduate School of Medicine, Nagoya University, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.

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